Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M13905 GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a neurophysiological process. 14/34 Gene Ontology BP GO:0031646 8.85384484416624e-10 1.50580225683018e-08 15 188.181818181818 33 8.04894986157224e-11 7 3.26335983996592 3.26335983996592 1 23.695441164793 26 211 449 33 736 38 12 7 15 522 21 2 M11939 GO_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHESION.html The attachment of a cell to the underlying substrate via adhesion molecules. 108/262 Gene Ontology BP GO:0031589 8.10701097609825e-20 7.52817039240484e-18 5 153.363636363636 37 7.37000997827113e-21 1 2.22990135052279 2.39336226796493 1 35.4439833360716 1 72 48 110 989 6 15 4 381 37 24 3 M11323 GO_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATRIX_ADHESION.html The binding of a cell to the extracellular matrix via adhesion molecules. 71/186 Gene Ontology BP GO:0007160 3.9169610123716e-17 2.02071666449348e-15 5 124.727272727273 43 3.56087364761054e-18 2 2.35601568634384 2.53941643434574 1 32.1367511674207 2 98 82 111 722 5 17 6 274 43 12 4 M12192 GO_DETECTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS.html The series of events by which a mechanical stimulus is received and converted into a molecular signal. 29/82 Gene Ontology BP GO:0050982 2.60562223982735e-13 7.70567137548941e-12 5 85.5454545454545 51 2.36874749075242e-14 2 2.55243541140043 2.66431870561913 1 26.3307130775848 6 152 146 51 230 2 5 35 174 129 11 5 M13801 GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 264/821 Gene Ontology BP GO:0000904 3.54948038026414e-23 5.88579907341657e-21 40 159.363636363636 55 3.22680034569466e-24 7 2.08994655248763 2.26094744301613 1 39.2468115013971 44 40 27 7 548 39 188 98 588 55 119 6 M16906 GO_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS.html The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. 56/161 Gene Ontology BP GO:0042476 1.17186640475589e-17 6.55539243045974e-16 35 118.909090909091 58 1.06533309523262e-18 5 2.81561720352365 2.96332996331839 1 39.6836692160396 35 117 77 26 417 15 40 5 344 174 58 7 M13894 GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. 36/71 Gene Ontology BP GO:0034446 3.67866616489332e-09 4.04740450322268e-08 20 338.909090909091 70 3.34424197367682e-10 12 2.21448009335643 2.28720176996733 1 15.1967685217451 16 938 513 70 1048 12 19 20 446 612 34 8 M10077 GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. 29/69 Gene Ontology BP GO:0007528 4.62991935300926e-13 1.2949828648206e-11 10 140.818181818182 72 4.20901759364568e-14 7 2.30203299501899 2.56619905578648 1 23.2658146242838 7 150 153 307 574 8 11 60 72 167 40 9 M14009 GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. 13/32 Gene Ontology BP GO:0072498 3.38738448785598e-14 1.12340186979395e-12 10 148.636363636364 75 3.07944044350548e-15 4 3.27919948799151 3.27919948799151 1 36.3735285684903 4 201 130 63 879 7 7 89 35 145 75 10 M10733 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. 21/59 Gene Ontology BP GO:0050974 2.10698103113641e-12 5.20357070615232e-11 10 150.181818181818 77 1.91543730103494e-13 4 2.92189769567913 2.99103952838375 1 27.8922456923357 10 169 174 77 866 4 9 48 84 197 14 11 M15014 GO_CONNECTIVE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNECTIVE_TISSUE_DEVELOPMENT.html The progression of a connective tissue over time, from its formation to the mature structure. 103/273 Gene Ontology BP GO:0061448 7.21593801302978e-18 4.18795002431216e-16 75 152.545454545455 82 6.55994364820887e-19 20 2.37791721574893 2.4293455503448 1 33.9442084095504 49 79 74 261 86 20 151 270 535 71 82 12 M15495 GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. 19/33 Gene Ontology BP GO:0033627 1.11888665996565e-11 2.5218401758352e-10 5 110.545454545455 83 1.01716969088303e-12 1 2.96085642702494 2.96085642702494 1 26.3803171914973 8 181 192 83 377 3 1 12 127 206 26 13 M10489 GO_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 85/264 Gene Ontology BP GO:0050808 1.20682092288005e-19 1.07755183556386e-17 115 94.0909090909091 86 1.09710992989096e-20 14 2.12578644165813 2.33267880992937 1 33.4817548949136 14 86 50 112 152 42 100 77 254 35 113 14 M13718 GO_CARDIAC_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 82/191 Gene Ontology BP GO:0003231 4.47431213608801e-18 2.66336298049444e-16 90 125.363636363636 86 4.06755648735272e-19 31 2.36106621340317 2.52464510623716 1 34.1344854974816 56 90 72 121 31 77 132 265 364 86 85 15 M14224 GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. 39/74 Gene Ontology BP GO:0007044 6.09433096356162e-11 1.25203445415118e-09 25 283.454545454545 86 5.54030087611859e-12 1 2.50167906966073 2.70044939225241 1 20.6731684206046 25 525 342 29 1425 33 86 1 287 328 37 16 M10512 GO_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 74/204 Gene Ontology BP GO:0051216 3.51016788965956e-15 1.35814245930744e-13 15 135.545454545455 90 3.19106171787233e-16 9 2.29293583416435 2.36146975736704 1 27.3867304211209 33 323 111 60 264 9 99 11 476 90 15 17 M15881 GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 56/141 Gene Ontology BP GO:0007229 2.57829284478378e-09 3.41694701612955e-08 45 140.636363636364 90 2.34390258891402e-10 41 2.22351590827447 2.42346455876537 1 15.4105594689493 42 114 269 158 71 41 90 43 278 367 74 18 M13631 GO_NEURON_PROJECTION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MORPHOGENESIS.html The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. 201/670 Gene Ontology BP GO:0048812 1.0694029293253e-15 4.5552640374838e-14 285 167.818181818182 100 9.72184481204811e-17 18 1.99703626865385 2.1467056396948 1 24.732004123528 34 284 100 18 282 27 133 78 671 81 138 19 M14391 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND.html The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. 11/35 Gene Ontology BP GO:0050910 1.37327455031906e-09 2.18360059490801e-08 80 232.181818181818 102 1.24843141016025e-10 25 3.35618771096006 3.54011489919135 1 23.8666258496932 78 213 255 81 1188 44 102 169 25 329 70 20 M14241 GO_RESPONSE_TO_BMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 44/151 Gene Ontology BP GO:0071772 1.05107422369735e-10 2.05912979773282e-09 220 154.181818181818 103 9.55522021588697e-12 36 2.7489408471559 2.77399974551745 1 22.1651243058409 52 518 218 67 220 36 43 45 134 260 103 21 M14474 GO_DETECTION_OF_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_ABIOTIC_STIMULUS.html The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. 70/227 Gene Ontology BP GO:0009582 1.16026857014825e-15 4.85326754162011e-14 105 145.636363636364 103 1.05478960922568e-16 40 2.30447314103574 2.47133193854989 1 28.4805404209966 98 101 102 142 180 45 103 263 398 40 130 22 M15778 GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 44/151 Gene Ontology BP GO:0071773 1.05107422369735e-10 2.05912979773282e-09 55 155.545454545455 104 9.55522021588697e-12 37 2.7489408471559 2.77399974551745 1 22.1651243058409 53 519 219 68 221 37 44 49 135 262 104 23 M16001 GO_POSITIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 65/178 Gene Ontology BP GO:0050921 1.56843808819087e-09 2.42186029290577e-08 90 338.363636363636 110 1.42585280846278e-10 22 2.06570324971132 2.18861311187237 1 14.6034511650592 47 110 256 607 492 22 63 88 1774 177 86 24 M12201 GO_TAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAXIS.html The directed movement of a motile cell or organism in response to an external stimulus. 219/733 Gene Ontology BP GO:0042330 4.20966902293756e-22 5.92287674954518e-20 60 240.454545454545 111 3.82697183903413e-23 30 2.21648899716766 2.27987274897391 1 39.5600472196745 57 758 32 30 50 111 202 178 977 54 196 25 M14070 GO_REGULATION_OF_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GASTRULATION.html Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. 31/69 Gene Ontology BP GO:0010470 6.40482560962732e-15 2.39819397624997e-13 5 126.818181818182 115 5.82256873602486e-16 1 2.49985498725062 2.58691527873119 1 29.2851391605282 3 354 115 120 391 1 6 24 251 123 7 26 M11606 GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 237/649 Gene Ontology BP GO:0051962 6.7710670349417e-15 2.51504513945875e-13 105 244 116 6.15551548631063e-16 29 1.92172564723316 2.18475769536479 1 22.4756498352698 104 468 116 304 568 54 150 29 735 96 60 27 M13352 GO_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULUS_DEVELOPMENT.html The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. 36/90 Gene Ontology BP GO:0032835 5.5542351025517e-21 5.99728222817385e-19 75 323.545454545455 116 5.04930463868334e-22 12 2.90933561995627 3.02929819178056 1 49.2107622042379 12 134 42 116 1598 72 113 750 265 73 384 28 M11475 GO_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 277/850 Gene Ontology BP GO:0031175 1.2809799346513e-14 4.61053475704341e-13 110 216.090909090909 119 1.16452721331937e-15 28 1.93447113387962 2.14062946716549 1 22.1520798408413 107 38 119 28 432 61 361 139 882 79 131 29 M13089 GO_RENAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_TUBULE_DEVELOPMENT.html The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. 46/137 Gene Ontology BP GO:0061326 1.91937277872413e-18 1.33009668830092e-16 65 171.090909090909 120 1.74488434429467e-19 12 2.55666314455905 2.86569878499704 1 37.6779214031072 205 120 64 12 56 291 468 185 61 101 319 30 M16608 GO_POSITIVE_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELINATION.html Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 8/16 Gene Ontology BP GO:0031643 9.66992049399888e-10 1.62671887150858e-08 35 690.181818181818 120 9.66992049820669e-11 4 3.88488431194714 3.88488431194714 1 28.0873980196981 131 872 4591 38 792 120 31 9 4 972 32 31 M13430 GO_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_MIGRATION.html Any process that modulates the frequency, rate or extent of neuron migration. 27/79 Gene Ontology BP GO:2001222 1.08767847558505e-10 2.12188704291655e-09 45 252.636363636364 123 9.8879861421711e-12 43 2.63394592969084 2.99729535163449 1 21.2060239346576 43 365 220 159 1456 62 58 123 66 135 92 32 M10631 GO_CARDIAC_CHAMBER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_MORPHOGENESIS.html The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. 74/183 Gene Ontology BP GO:0003206 9.97551950677539e-20 9.08163471959963e-18 90 180.909090909091 124 9.06865409706853e-21 26 2.45188008621418 2.71448143255913 1 38.7868711275899 89 93 49 124 26 193 333 380 387 58 258 33 M15608 GO_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_GUIDANCE.html The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. 96/347 Gene Ontology BP GO:0097485 2.32272157961909e-14 8.04805693594883e-13 315 130.454545454545 124 2.111565072381e-15 16 2.3029405818598 2.44576252276648 1 25.8543087348054 21 311 124 16 94 58 154 44 314 131 168 34 M10505 GO_COLLAGEN_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_FIBRIL_ORGANIZATION.html Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. 27/60 Gene Ontology BP GO:0030199 8.84075603845522e-15 3.20684611613653e-13 200 248.272727272727 125 8.0370509440502e-16 5 2.75869099845731 2.92781859029951 1 31.9941799677769 5 536 118 364 1069 48 20 125 198 51 197 35 M11382 GO_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins. 22/47 Gene Ontology BP GO:0097435 4.26691639261678e-08 1.76127790903934e-07 20 283.727272727273 133 3.87901497761268e-09 14 2.70116947531846 2.74945276324385 1 16.9353077701172 19 167 335 204 1733 21 14 116 133 300 79 36 M10039 GO_CARDIAC_CHAMBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_DEVELOPMENT.html The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. 99/257 Gene Ontology BP GO:0003205 2.43761596927381e-16 1.12057930151864e-14 70 189.545454545455 134 2.21601451752164e-17 9 2.2479177035011 2.41680845672406 1 29.1099263943604 68 81 92 134 9 180 265 381 503 99 273 37 M16018 GO_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. 131/386 Gene Ontology BP GO:0042692 6.86740698799005e-19 5.06116994368854e-17 95 274.818181818182 134 6.24309726180912e-20 60 2.44654595352878 2.73946705807695 1 37.0081048805273 92 66 60 130 480 134 250 564 729 114 404 38 M11955 GO_REPLACEMENT_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLACEMENT_OSSIFICATION.html Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. 18/52 Gene Ontology BP GO:0036075 6.08449751962788e-14 1.93495356052276e-12 180 201.363636363636 135 5.53136138148003e-15 69 3.03534865300733 3.51792162655973 1 33.003354273213 179 178 135 169 907 81 72 69 122 178 125 39 M15454 GO_ENDOCHONDRAL_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_OSSIFICATION.html Replacement ossification wherein bone tissue replaces cartilage. 18/52 Gene Ontology BP GO:0001958 6.08449751962788e-14 1.93495356052276e-12 180 202.727272727273 136 5.53136138148003e-15 73 3.03534865300733 3.51792162655973 1 33.003354273213 180 179 136 170 908 82 73 74 123 179 126 40 M13648 GO_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 296/777 Gene Ontology BP GO:0007507 9.27979964722856e-22 1.22686339431788e-19 35 297.727272727273 139 8.43618149748047e-23 34 2.04488096093693 2.29603825792408 1 35.896850463789 88 34 34 34 139 387 537 421 1074 50 477 41 M15872 GO_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 66/188 Gene Ontology BP GO:0072006 2.29361465580381e-27 5.60486991941952e-25 60 189.545454545455 140 2.08510423254892e-28 3 2.72698751523204 2.96305567447461 1 61.3888817607498 59 97 19 3 242 187 324 548 140 29 437 42 M15221 GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of embryonic development. 68/180 Gene Ontology BP GO:0045995 9.94900911065942e-14 3.03902955926261e-12 145 172.363636363636 144 9.04455373696353e-15 19 2.31232538300554 2.60261631208001 1 24.7210804365093 85 325 141 144 256 59 173 19 419 214 61 43 M12415 GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. 26/50 Gene Ontology BP GO:0048745 6.25168606138498e-11 1.27870389352469e-09 210 129 145 5.68335096505695e-12 23 2.46017818052446 2.8585232833192 1 20.3093126443751 70 157 210 184 233 50 23 47 92 208 145 44 M14840 GO_STRIATED_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_PROLIFERATION.html The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. 13/29 Gene Ontology BP GO:0014855 7.55804604683886e-09 5.8723265524949e-08 110 540.545454545455 147 6.87095097527666e-10 31 2.47975806015011 2.47975806015011 1 16.64516897847 110 1246 810 595 1948 67 52 31 147 899 41 45 M10925 GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of neuron differentiation. 181/480 Gene Ontology BP GO:0045666 2.97300582997413e-13 8.62729129285618e-12 150 243.181818181818 149 2.70273257270412e-14 43 1.95250581566788 2.23685081967383 1 20.0529637518092 128 290 149 306 566 57 253 85 650 148 43 46 M12305 GO_HEMIDESMOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMIDESMOSOME_ASSEMBLY.html Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. 13/25 Gene Ontology BP GO:0031581 1.87122639161293e-07 5.36965645009817e-07 155 340.363636363636 151 1.70111504615591e-08 9 3.18285691069574 3.18285691069574 1 18.5249693781855 23 562 400 9 1809 83 41 154 46 466 151 47 M16954 GO_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of vasculature development. 147/372 Gene Ontology BP GO:1901342 1.7568542826368e-21 2.09155754725197e-19 20 340.909090909091 152 1.59714025694254e-22 17 2.20846241687973 2.35618603667373 1 38.2935034701141 17 623 38 562 528 121 152 118 1256 44 291 48 M14876 GO_UROGENITAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UROGENITAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. 164/437 Gene Ontology BP GO:0001655 2.68124415687844e-28 8.49256120821367e-26 190 205.090909090909 155 2.43749468807129e-29 14 2.36556330714512 2.50248142637407 1 55.0522029849301 186 59 14 20 74 155 289 567 509 34 349 49 M13527 GO_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. 32/126 Gene Ontology BP GO:0021675 3.24294094668024e-08 1.44223896699582e-07 75 281.818181818182 156 2.94812817680296e-09 31 2.1167603015322 2.36386789194969 1 13.4418190536901 74 156 511 385 934 31 39 109 316 472 73 50 M16870 GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. 111/365 Gene Ontology BP GO:0010466 5.2095236647338e-13 1.43123185653012e-11 285 260 156 4.73593060430458e-14 66 2.07704941058133 2.3081941322763 1 20.9082213544777 282 71 156 549 126 93 336 66 864 239 78 51 M13053 GO_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DIFFERENTIATION.html The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. 37/95 Gene Ontology BP GO:0002062 1.61619222108081e-12 4.19216786730625e-11 70 275.272727272727 159 1.46926565552909e-13 32 2.626742077467 2.77459003695399 1 25.3035746598139 69 528 165 426 1075 32 51 134 250 139 159 52 M13090 GO_CARDIAC_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_MORPHOGENESIS.html The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 47/124 Gene Ontology BP GO:0003208 5.57078128876418e-20 5.50322074973024e-18 160 182.909090909091 159 5.06434662614925e-21 45 2.99432919149508 3.34436822017704 1 47.9726768456649 159 122 45 118 63 305 263 403 184 68 282 53 M12574 GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. 24/49 Gene Ontology BP GO:0036296 2.174649798336e-10 4.10443049336344e-09 40 230.545454545455 161 1.97695436231905e-11 16 2.5767280093262 2.71754386282106 1 20.0600154445108 36 371 226 341 905 16 33 214 161 118 115 54 M16151 GO_AORTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_MORPHOGENESIS.html The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. 25/54 Gene Ontology BP GO:0035909 1.80374984909525e-11 3.96910452575795e-10 110 161.909090909091 161 1.63977259010004e-12 81 2.60935066882485 3.06362710665482 1 22.7714057690267 108 161 196 163 182 133 81 144 109 318 186 55 M16350 GO_RESPONSE_TO_WATER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. 12/31 Gene Ontology BP GO:0009415 8.65719313604955e-11 1.73255809183957e-09 265 227.363636363636 161 7.87017557853654e-12 2 2.70327657727786 3.22584854455865 1 21.9851167196555 264 218 480 57 149 117 161 2 258 779 16 56 M15782 GO_RESPONSE_TO_HYPEROXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYPEROXIA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. 24/49 Gene Ontology BP GO:0055093 2.174649798336e-10 4.10443049336344e-09 120 230.454545454545 162 1.97695436231905e-11 17 2.5767280093262 2.71754386282106 1 20.0600154445108 37 372 227 342 906 17 34 203 162 119 116 57 M12344 GO_NEPHRIC_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. 16/29 Gene Ontology BP GO:0072176 2.18193015404742e-09 3.05141617627776e-08 165 268.090909090909 164 1.98357286928312e-10 39 2.17641160441991 2.36584431538263 1 15.1833626434144 164 957 584 220 55 104 61 39 196 493 76 58 M14182 GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in an epithelial cell. 26/55 Gene Ontology BP GO:1904019 7.22774001365924e-09 5.77597192485712e-08 300 257.090909090909 164 6.57067276127709e-10 9 2.70505129277305 2.98778018454958 1 18.1754727762768 300 164 295 90 990 154 118 42 207 459 9 59 M10764 GO_RESPONSE_TO_CORTICOSTEROID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTEROID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 107/288 Gene Ontology BP GO:0031960 1.25933680046961e-21 1.58029750394064e-19 375 338.090909090909 165 1.14485163679055e-22 35 2.47463692695939 2.74590445580421 1 43.1884493383475 374 76 36 35 90 951 692 165 636 105 559 60 M16924 GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. 154/418 Gene Ontology BP GO:0043062 8.26557454481827e-40 1.27923542038638e-36 5 224.090909090909 168 7.51415867710751e-41 1 2.26420497593441 2.55446734014163 1 75.4388813359756 9 57 3 301 797 129 190 168 500 1 310 61 M11062 GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. 15/37 Gene Ontology BP GO:0035025 1.3914492560249e-11 3.07642804558267e-10 25 146.454545454545 171 1.26495386912154e-12 16 3.17556077653739 3.31695163580979 1 28.0387904373134 22 197 195 171 428 25 16 219 49 224 65 62 M11506 GO_TOOTH_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOOTH_MINERALIZATION.html The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. 13/32 Gene Ontology BP GO:0034505 1.366496393276e-11 3.0357142363543e-10 35 136.272727272727 173 1.24226944844044e-12 32 2.93407708700269 3.07523134471494 1 25.922355069852 32 200 194 173 82 46 115 205 36 226 190 63 M15980 GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. 32/73 Gene Ontology BP GO:0051057 1.69153230143324e-12 4.36321359753031e-11 175 174.272727272727 174 1.53775663766777e-13 46 2.89512239020411 3.09668908574087 1 27.8422247671057 76 356 166 174 46 174 95 142 204 295 189 64 M15451 GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 274/721 Gene Ontology BP GO:0010720 2.21992261057621e-18 1.50810290381526e-16 150 254.454545454545 175 2.0181114641602e-19 53 1.95465936206802 2.30177123364744 1 28.7071298253567 149 272 65 305 552 175 299 53 707 100 122 65 M11013 GO_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of a tissue are generated and organized. 311/815 Gene Ontology BP GO:0048729 3.56360332266827e-30 1.75054478535862e-27 10 225.090909090909 176 3.2396393842439e-31 9 2.10953061373466 2.24700243071156 1 52.3949680473636 94 31 9 10 265 176 390 389 796 24 292 66 M16960 GO_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. 90/259 Gene Ontology BP GO:0048592 2.70457320493309e-14 9.09951694964084e-13 295 188.909090909091 176 2.45870291357557e-15 83 2.22018395761928 2.50085630851019 1 24.8153265131526 87 313 128 149 217 135 294 176 291 83 205 67 M12965 GO_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 31/83 Gene Ontology BP GO:0061383 8.68062334924101e-08 2.93547954920073e-07 45 371.272727272727 177 7.89147608341427e-09 41 3.0075051425147 3.17524429506585 1 18.2365646256716 41 810 352 227 1407 69 91 99 177 684 127 68 M16714 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. 14/36 Gene Ontology BP GO:0043206 3.70405076215776e-10 6.71793269089784e-09 15 259.636363636364 181 3.3673188752558e-11 13 3.06760329196475 3.06760329196475 1 23.2721930325017 13 202 235 192 1490 34 24 298 43 181 144 69 M15575 GO_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. 28/74 Gene Ontology BP GO:0060350 7.40098424742073e-13 2.02133940357497e-11 115 312.545454545455 182 6.72816749765747e-14 113 2.63364575594549 3.01549463234007 1 26.144559441868 312 359 157 155 1420 201 182 115 180 113 244 70 M16627 GO_NEPHRIC_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_MORPHOGENESIS.html The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. 14/25 Gene Ontology BP GO:0072178 3.02936466177556e-09 3.71516474551579e-08 180 335.545454545455 182 2.7539678781336e-10 45 2.24644531420168 2.33204353068014 1 15.4936978612556 176 1079 699 350 101 150 45 136 248 525 182 71 M13073 GO_ENDODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. 31/73 Gene Ontology BP GO:0035987 6.22931685761085e-10 1.10392054083539e-08 85 299.909090909091 183 5.66301532670427e-11 35 2.54425535591149 2.79852632770499 1 18.7924146773946 84 153 240 282 1395 70 35 170 348 339 183 72 M12538 GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. 35/94 Gene Ontology BP GO:0003229 1.43126691871213e-15 5.82927395050914e-14 250 266 186 1.30115174428375e-16 105 3.25155992430307 3.55856472214835 1 39.9452077555563 249 147 105 131 111 345 478 623 173 186 378 73 M15294 GO_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_FORMATION.html The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 16/51 Gene Ontology BP GO:0060343 5.48739315480024e-09 4.97122471997677e-08 20 269.545454545455 188 4.98853924407934e-10 20 2.90629713737564 3.12583161766003 1 19.7034539008725 20 191 292 97 1230 30 46 260 117 494 188 74 M11549 GO_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_PROLIFERATION.html The expansion of a muscle cell population by cell division. 14/33 Gene Ontology BP GO:0033002 1.26285304067249e-08 7.84929942147576e-08 190 580.454545454545 189 1.14804822538325e-09 35 2.47975806015011 2.47975806015011 1 16.3550872774225 189 1473 901 501 1924 115 36 41 152 1018 35 75 M11483 GO_CHONDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. 19/43 Gene Ontology BP GO:0002063 2.08767318056399e-08 1.05935153850914e-07 190 265.272727272727 190 1.89788472761346e-09 23 2.86399633321491 3.09008207681751 1 18.5431414039487 190 683 313 213 886 40 84 101 97 288 23 76 M12492 GO_ARTERY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_MORPHOGENESIS.html The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. 41/97 Gene Ontology BP GO:0048844 2.17577564487592e-14 7.5955836986157e-13 200 200.454545454545 190 1.97797785897811e-15 115 2.38144093934557 2.8129450164416 1 26.7911567814486 115 132 123 168 161 190 200 294 370 196 256 77 M14448 GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. 15/36 Gene Ontology BP GO:0060351 2.10504193367732e-09 2.97978954209262e-08 35 309.818181818182 190 1.91367448699228e-10 32 2.76282481593938 2.9046833988729 1 19.3008301995025 38 190 262 191 1947 52 32 286 34 152 224 78 M16086 GO_BASEMENT_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. 19/31 Gene Ontology BP GO:0071711 9.29911223822305e-12 2.10613551814974e-10 15 393.454545454545 191 8.45373839842033e-13 15 2.82170547644688 2.88416782786935 1 25.3454341674981 15 550 191 312 2141 98 79 402 85 102 353 79 M14540 GO_RESPONSE_TO_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 294/708 Gene Ontology BP GO:0070848 2.16551765521227e-17 1.16903378137787e-15 40 245.818181818182 192 1.96865241382932e-18 36 1.92767578582091 2.1034513073295 1 26.7193655816466 220 36 79 65 39 192 264 356 943 154 356 80 M13997 GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. 28/57 Gene Ontology BP GO:0045992 3.45894556968306e-10 6.3227890866293e-09 195 213.545454545455 195 3.14449597293354e-11 86 2.42409350658032 2.76732332163263 1 18.4494841786143 109 158 233 86 454 147 194 296 282 195 195 81 M13484 GO_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 212/583 Gene Ontology BP GO:0052547 4.04141345315568e-12 9.62270905794966e-11 430 337 196 3.67401223014828e-13 50 1.84151796481733 2.13449740106681 1 17.1226065952997 426 50 181 555 196 223 519 117 1195 192 53 82 M10531 GO_CIRCULATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. 197/596 Gene Ontology BP GO:0003013 1.41291629997406e-28 5.46680865064963e-26 30 280 201 1.28446936361279e-29 12 2.38084427877443 2.54369312448207 1 55.8306183015342 27 52 12 251 682 75 201 624 804 20 332 83 M15430 GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION.html The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. 183/616 Gene Ontology BP GO:0048667 2.53825777212574e-11 5.44948874545041e-10 65 294.727272727273 201 2.30750706559548e-12 60 2.04867722379586 2.22933416152549 1 17.6166994257794 60 900 201 136 472 64 223 64 658 277 187 84 M13151 GO_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MORPHOGENESIS.html Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 425/1215 Gene Ontology BP GO:0009887 1.11952393401388e-43 2.59897481281321e-40 5 318.909090909091 202 1.0177490309217e-44 2 2.12200270871322 2.36843131692076 1 77.973655659502 155 25 2 2 202 569 637 506 868 5 537 85 M11134 GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. 96/294 Gene Ontology BP GO:0051146 5.44078775606389e-14 1.76654388471361e-12 210 240.545454545455 207 4.94617068733093e-15 88 2.55451856817526 2.86202616874311 1 27.869061315509 97 88 133 139 418 113 208 384 528 207 331 86 M13993 GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. 98/268 Gene Ontology BP GO:0048738 5.19038133750157e-19 4.01649009166997e-17 60 202.454545454545 207 4.71852848863777e-20 55 2.61394456269779 2.85272421281631 1 39.7839117567447 58 83 57 257 251 55 207 434 472 106 247 87 M16767 GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM.html A circulatory process that occurs at the level of the vasculature. 84/233 Gene Ontology BP GO:0003018 4.85396604029561e-12 1.14400834137525e-10 185 428.818181818182 207 4.41269640027846e-13 67 2.29554823552456 2.28999350680654 1 21.1841269844046 67 777 183 374 721 71 155 891 1086 185 207 88 M15499 GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS.html The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. 14/31 Gene Ontology BP GO:0035313 4.01566798797354e-11 8.32354753042908e-10 100 227 208 3.65060726186077e-12 28 3.19651308226914 3.29321525393912 1 26.9411865848563 99 203 208 211 749 28 53 277 178 270 221 89 M15954 GO_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 704/2148 Gene Ontology BP GO:0048468 5.58781993208574e-17 2.78970408007248e-15 175 692.272727272727 210 5.58781993208576e-18 5 1.97509603369694 2.20563754981149 1 26.6841216234088 174 451 4487 5 169 191 579 210 1107 13 229 90 M10101 GO_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 336/1049 Gene Ontology BP GO:0048666 4.73826485787311e-16 2.07544940897216e-14 150 289.363636363636 212 4.30751350715738e-17 25 1.89804174764603 2.11708162219743 1 24.107527254384 148 267 97 25 403 145 508 230 1091 57 212 91 M14065 GO_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 140/418 Gene Ontology BP GO:0008544 6.17029822963238e-20 5.84667238371085e-18 195 270.818181818182 213 5.6093620269385e-21 27 2.29637141129419 2.65998642296013 1 36.7345275538163 191 485 47 27 323 358 470 198 582 85 213 92 M10670 GO_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_PRIMARY_GERM_LAYER.html The formation of the ectoderm, mesoderm and endoderm during gastrulation. 77/178 Gene Ontology BP GO:0001704 7.67206616349325e-11 1.54205208645451e-09 55 277.545454545455 214 6.97460560341891e-12 51 2.1208864083236 2.20283825774372 1 17.3482692237708 51 100 214 82 700 116 168 262 666 398 296 93 M14991 GO_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 86/261 Gene Ontology BP GO:0050920 8.94669910404225e-11 1.77519333077214e-09 50 435.272727272727 216 8.13336282218737e-12 46 2.03294000238357 2.24045191137925 1 16.5135022774497 46 91 216 798 874 141 193 268 1755 153 253 94 M15330 GO_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron. 417/1295 Gene Ontology BP GO:0030182 5.70824805129192e-20 5.52154077128092e-18 50 279.363636363636 216 5.18931641026537e-21 15 1.94223632228546 2.19048081003347 1 31.1143088800309 193 262 46 15 245 204 560 216 1064 48 220 95 M11108 GO_NEGATIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LOCOMOTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. 165/444 Gene Ontology BP GO:0040013 3.16495791490034e-18 1.93353942090556e-16 40 340.090909090909 217 2.87723446809122e-19 40 2.03275880536636 2.23359817192634 1 29.6504973211641 40 618 70 360 776 112 131 328 994 95 217 96 M13140 GO_CHEMOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of chemicals. 6/29 Gene Ontology BP GO:0007635 3.87364823290238e-07 9.81469538623015e-07 205 833.181818181818 218 3.87364890813432e-08 94 2.52334035500746 2.52334035500746 1 14.0729063293892 202 591 4018 945 1897 184 94 218 187 665 164 97 M15958 GO_TELENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. 135/430 Gene Ontology BP GO:0021537 1.30593204789708e-10 2.53700522945027e-09 215 287.636363636364 221 1.18721095270418e-11 23 2.35439624673139 2.6138137934995 1 18.7857641099554 214 487 221 92 764 65 241 23 483 535 39 98 M12034 GO_AORTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_DEVELOPMENT.html The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. 38/106 Gene Ontology BP GO:0035904 1.98326844902164e-10 3.80508901190391e-09 140 274.363636363636 223 1.80297131745493e-11 137 2.54599757744358 2.94904477517707 1 19.8985026807012 139 142 223 178 307 537 374 143 137 372 466 99 M11227 GO_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DIFFERENTIATION.html The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. 104/262 Gene Ontology BP GO:0001649 3.2735980044046e-09 3.84357595519315e-08 140 479.363636363636 224 2.97599819025065e-10 30 2.05427228670735 2.1963069440828 1 14.1401426886167 140 1283 475 659 118 80 139 224 1289 836 30 100 M15024 GO_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOMINERAL_TISSUE_DEVELOPMENT.html Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. 39/111 Gene Ontology BP GO:0031214 1.40631326697646e-12 3.70995028327936e-11 140 262.545454545455 226 1.27846660634305e-13 77 2.50063299535485 2.73319620946592 1 24.2119470588276 77 138 162 274 617 136 226 110 512 269 367 101 M15636 GO_CELLULAR_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 29/58 Gene Ontology BP GO:0071295 2.48583952118321e-10 4.65393261969905e-09 55 339.272727272727 229 2.2598541104219e-11 43 2.57489939393511 2.62763714011659 1 19.9153545048384 54 540 229 486 751 43 195 150 842 287 155 102 M14200 GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS.html A multicellular organism process which involves another multicellular organism of the same or different species. 112/337 Gene Ontology BP GO:0044706 1.38821574546534e-22 2.14849523539853e-20 235 445.181818181818 232 1.2620143140594e-23 29 2.48136806119274 2.45913644611965 1 45.3020192434539 232 73 29 49 199 588 689 1254 1130 88 566 103 M12279 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE.html Any process that modulates the size of an anatomical structure. 270/671 Gene Ontology BP GO:0090066 1.41391814314813e-15 5.80957693684668e-14 125 399.636363636364 233 1.28538013013466e-16 104 1.97101400863399 2.16352973069536 1 24.216471647937 124 896 104 259 556 126 233 627 1151 147 173 104 M14697 GO_CELLULAR_COMPONENT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MORPHOGENESIS.html The process in which cellular structures, including whole cells or cell parts, are generated and organized. 484/1351 Gene Ontology BP GO:0032989 1.57964255788111e-21 1.93007378848474e-19 235 266.727272727273 233 1.43603868898283e-22 6 1.89097857255564 2.10217195945624 1 32.8497645010599 233 17 37 6 299 213 620 301 821 46 341 105 M12926 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 26/63 Gene Ontology BP GO:2001240 7.40855649017015e-09 5.85221359566564e-08 30 256.454545454545 234 6.73505137738061e-10 3 2.69141499424161 2.76451819567691 1 18.0696210828843 30 373 370 234 1028 10 3 37 262 457 17 106 M16493 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. 26/63 Gene Ontology BP GO:1901099 7.40855649017015e-09 5.85221359566564e-08 35 257.363636363636 235 6.73505137738061e-10 4 2.69141499424161 2.76451819567691 1 18.0696210828843 31 374 371 235 1029 11 4 34 263 461 18 107 M12739 GO_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of neuron differentiation. 298/801 Gene Ontology BP GO:0045664 1.13868218815344e-18 8.01045666605518e-17 65 261 236 1.03516562559403e-19 14 1.92360094502964 2.19230715606155 1 28.741625841384 182 269 63 14 355 236 462 282 781 62 165 108 M13197 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 37/84 Gene Ontology BP GO:2001239 2.77812067527819e-09 3.58986203139073e-08 15 303.181818181818 236 2.52556425344213e-10 5 2.55515219166501 2.72297577168023 1 17.6581855646051 61 353 399 236 1303 14 26 14 386 538 5 109 M11450 GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 390/1070 Gene Ontology BP GO:0051960 9.32563465475129e-23 1.49306626558656e-20 170 244.909090909091 237 8.4778496861375e-24 11 1.8758390406725 2.17156357163608 1 34.5221694157592 169 263 28 11 353 237 371 122 875 22 243 110 M13572 GO_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION.html A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. 102/242 Gene Ontology BP GO:0007369 2.90819314793296e-11 6.10983745966187e-10 65 319.090909090909 237 2.64381195270126e-12 63 2.17244034579917 2.2586206668992 1 18.5807742703157 63 85 205 88 612 160 272 237 1124 416 248 111 M14932 GO_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_DEVELOPMENT.html The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. 97/268 Gene Ontology BP GO:0060485 1.10231023758005e-18 7.87388682012947e-17 80 304.909090909091 239 1.00210021598186e-19 40 2.23451921003089 2.48657325681138 1 33.4027245761229 80 766 62 40 435 247 239 370 749 138 228 112 M12549 GO_PROTEIN_HETEROTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTRIMERIZATION.html The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. 16/31 Gene Ontology BP GO:0070208 2.75877851851955e-08 1.28993037880023e-07 115 318.181818181818 240 2.50798050283124e-09 89 3.20022732369159 3.20022732369159 1 20.4660246924054 111 199 417 296 877 89 127 375 93 676 240 113 M14896 GO_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_DEVELOPMENT.html The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. 191/528 Gene Ontology BP GO:0001654 3.37794913592521e-18 2.03685945949361e-16 240 301.727272727273 240 3.07086285084109e-19 53 2.03138556411881 2.29772465985027 1 29.5878358872315 240 53 71 132 108 458 479 490 667 82 539 114 M12381 GO_PATTERNING_OF_BLOOD_VESSELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERNING_OF_BLOOD_VESSELS.html The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. 30/76 Gene Ontology BP GO:0001569 5.14455335770884e-08 2.00892861563012e-07 45 324.818181818182 241 4.67686679819163e-09 35 2.98377006601925 2.98377006601925 1 18.5488543438034 45 542 349 241 1090 35 42 226 279 629 95 115 M15406 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 615/1669 Gene Ontology BP GO:0051094 2.27368518774647e-18 1.50810290381526e-16 245 723.272727272727 244 2.27368518774647e-19 7 1.94155116931243 2.19025523967472 1 28.5146161827316 244 11 4400 109 223 521 517 158 1375 7 391 116 M12651 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate, or extent of leukocyte migration. 55/148 Gene Ontology BP GO:0002687 8.49762060673935e-10 1.45053134106951e-08 105 497.181818181818 246 7.72510964547416e-11 84 2.02526173971281 2.2102408522582 1 14.7360726782576 105 337 246 912 969 84 89 138 2115 252 222 117 M12556 GO_MESENCHYMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. 69/195 Gene Ontology BP GO:0048762 7.68728502910202e-14 2.39544056309535e-12 105 326 247 6.98844093554752e-15 59 2.16106783572634 2.42112836484707 1 23.3113076502039 101 638 138 59 536 252 247 348 849 238 180 118 M14533 GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 233/622 Gene Ontology BP GO:0010975 3.07259277294655e-15 1.20898713938905e-13 230 300.636363636364 252 2.79326615722414e-16 109 1.96167652386911 2.24005636831436 1 23.5221836585073 230 279 109 252 550 265 452 209 688 112 161 119 M12378 GO_PALATE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALATE_DEVELOPMENT.html The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. 67/155 Gene Ontology BP GO:0060021 8.69896680843867e-13 2.33464178564051e-11 220 308.090909090909 253 7.90815164403829e-14 121 2.09329000953508 2.31959765872757 1 20.6587723341915 121 637 159 277 420 217 368 253 579 140 218 120 M15812 GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE.html Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. 7/23 Gene Ontology BP GO:0051969 1.66634102680442e-07 4.91538842913147e-07 240 781.545454545455 255 1.66634115175559e-08 64 2.75433896659906 2.75433896659906 1 16.1290448052095 203 240 4461 436 1534 78 64 236 289 801 255 121 M15224 GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. 19/42 Gene Ontology BP GO:0061298 1.59762109351969e-09 2.44005090039865e-08 15 366.454545454545 257 1.45238281334533e-10 13 3.10762374842545 3.10762374842545 1 21.9599144585411 29 554 257 351 1792 13 13 339 242 386 55 122 M13677 GO_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. 311/798 Gene Ontology BP GO:0035295 2.19125794780644e-22 3.28193891989204e-20 35 356.818181818182 259 1.99205267982404e-23 30 2.00213403503315 2.11771739235844 1 36.2107483644055 259 32 30 31 80 597 532 674 997 59 634 123 M15056 GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. 31/101 Gene Ontology BP GO:0042475 1.95013038205916e-09 2.79458498885824e-08 345 457.545454545455 259 1.77284580344346e-10 10 2.619026462931 2.97271375233996 1 18.3640201520609 343 1791 465 45 824 259 184 10 226 685 201 124 M16968 GO_HEAD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_MORPHOGENESIS.html The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. 28/69 Gene Ontology BP GO:0060323 6.62428694557721e-08 2.38422978979186e-07 160 424.818181818182 259 6.022079222761e-09 128 2.45358872743697 2.78507915851577 1 15.0835244519623 156 541 493 616 1190 128 159 227 259 688 216 125 M12799 GO_NEPHRON_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. 44/140 Gene Ontology BP GO:0072009 2.36761897959904e-11 5.13684809452259e-10 1225 839.454545454545 261 2.15238089056775e-12 23 2.24153231780303 2.41044899834207 1 19.3284614026387 1224 129 199 23 59 2043 1436 2196 261 259 1405 126 M15227 GO_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MORPHOGENESIS.html The process in which bones are generated and organized. 47/125 Gene Ontology BP GO:0060349 5.79865474394478e-12 1.34330378840811e-10 265 267.818181818182 261 5.27150431269096e-13 56 2.31533881663492 2.6841815637413 1 21.21686300647 261 340 186 328 674 198 353 56 322 110 118 127 M12594 GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 94/241 Gene Ontology BP GO:0071453 9.51999305714824e-10 1.60732100961234e-08 270 740.545454545455 266 8.65453914660711e-11 7 1.71710783291896 1.83474695102332 1 12.4228541846007 266 1718 1075 1501 7 167 185 174 2073 889 91 128 M16378 GO_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 153/370 Gene Ontology BP GO:0009612 4.42718674729161e-14 1.45783177784929e-12 195 320.090909090909 266 4.02471522481062e-15 131 2.29283109806609 2.64140671067261 1 25.1916662764238 192 296 131 176 616 359 419 148 675 243 266 129 M10869 GO_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WOUNDING.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. 333/807 Gene Ontology BP GO:0009611 7.68624526424414e-22 1.04962461064369e-19 185 435.636363636364 268 6.98749569476741e-23 33 2.07229193316895 2.32844376440321 1 36.5083851814806 185 268 33 255 822 581 717 229 1111 67 524 130 M13025 GO_CELL_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGGREGATION.html The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. 17/45 Gene Ontology BP GO:0098743 2.55866583353045e-11 5.44948874545041e-10 480 305 269 2.32605984869109e-12 55 3.07717176835882 3.54519139478783 1 26.4607863575099 476 187 202 160 342 449 269 634 55 219 362 131 M16745 GO_CARTILAGE_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_CONDENSATION.html The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. 17/45 Gene Ontology BP GO:0001502 2.55866583353045e-11 5.44948874545041e-10 480 306 270 2.32605984869109e-12 56 3.07717176835882 3.54519139478783 1 26.4607863575099 477 188 203 161 343 450 270 635 56 220 363 132 M14199 GO_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSSIFICATION.html The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. 166/459 Gene Ontology BP GO:0001503 6.6942778893515e-10 1.18180730951555e-08 190 403.363636363636 272 6.08570717398954e-11 143 1.97326066621651 2.19583900079784 1 14.5206911763658 188 621 241 440 545 197 234 272 1271 285 143 133 M16368 GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving mucopolysaccharide. 56/130 Gene Ontology BP GO:1903510 2.92518909294152e-09 3.65029676110884e-08 125 505.181818181818 272 2.65926281530086e-10 125 1.9602949516877 2.11434262318424 1 13.5340435373724 125 507 272 1301 925 185 217 200 1313 173 339 134 M16477 GO_INNERVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNERVATION.html The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. 7/39 Gene Ontology BP GO:0060384 1.45538569855607e-08 8.59714478167408e-08 75 811.909090909091 272 1.45538570808773e-09 10 3.0132579972952 3.0132579972952 1 19.763202275578 130 586 4570 725 1666 26 71 73 272 802 10 135 M10360 GO_BONE_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. 12/39 Gene Ontology BP GO:0061430 5.66763499767754e-08 2.14990435410268e-07 25 455.363636363636 273 5.15239558517004e-09 24 3.08981056304509 3.08981056304509 1 19.1235837638047 24 846 339 226 2286 146 80 327 37 273 425 136 M13139 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET.html The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. 42/92 Gene Ontology BP GO:0002011 2.22610291975444e-09 3.09454965761073e-08 165 354.454545454545 274 2.02372992909723e-10 129 2.26967392385344 2.45635401318399 1 15.8211478907908 163 522 264 201 487 238 599 625 397 274 129 137 M13687 GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 265/679 Gene Ontology BP GO:0009991 7.57344459524756e-16 3.2863087154892e-14 440 374.090909090909 274 6.88494963204322e-17 56 2.10457530909638 2.42401728335063 1 26.3408350161855 437 274 98 423 124 240 614 257 1232 360 56 138 M14729 GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. 105/287 Gene Ontology BP GO:0001763 2.67799919831504e-18 1.68026355105091e-16 275 292.272727272727 274 2.43454472574093e-19 69 2.39896745672344 2.68164745972548 1 35.1279231414891 274 78 69 152 91 567 525 473 315 111 560 139 M14503 GO_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 258/735 Gene Ontology BP GO:0042493 9.51261731540892e-22 1.22686339431788e-19 270 430.909090909091 275 8.64783392309902e-23 24 2.13969899514341 2.46409487770359 1 37.561333081375 269 275 35 24 961 786 694 238 931 94 433 140 M15223 GO_SENSORY_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. 257/760 Gene Ontology BP GO:0007423 1.75062219256313e-19 1.50111718257743e-17 175 329.909090909091 276 1.59147472051193e-20 52 1.98087698535941 2.22840506348899 1 30.9346497196492 175 276 52 133 110 323 409 457 1198 66 430 141 M16294 GO_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXONOGENESIS.html Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. 97/250 Gene Ontology BP GO:0050770 2.72350655266655e-09 3.55203396742438e-08 165 379.454545454545 276 2.47591505094377e-10 162 2.18552101914384 2.46184804448405 1 15.1130661398066 162 1120 267 373 276 230 448 223 514 389 172 142 M10365 GO_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_TISSUE_DEVELOPMENT.html The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. 155/442 Gene Ontology BP GO:0060537 5.36154000610066e-19 4.08092299152875e-17 85 262.454545454545 278 4.87412727827331e-20 58 2.42468515067325 2.71494452912672 1 36.8878505761553 81 294 58 365 306 105 251 374 659 116 278 143 M12572 GO_MUSCLE_STRUCTURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_STRUCTURE_DEVELOPMENT.html The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. 239/653 Gene Ontology BP GO:0061061 1.85391019433264e-27 4.78205835127025e-25 65 281.545454545455 278 1.68537290393875e-28 18 2.28018914169125 2.59613117770361 1 51.476672001815 62 278 18 455 334 92 309 342 885 47 275 144 M16634 GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 152/389 Gene Ontology BP GO:0010976 2.6470287949566e-10 4.93580509838694e-09 150 330.909090909091 280 2.40638981388644e-11 63 1.99554723188036 2.27422413344407 1 15.3870952222668 147 297 230 497 811 103 280 258 637 317 63 145 M15217 GO_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. 194/509 Gene Ontology BP GO:0035239 3.49538618945806e-16 1.56048827669748e-14 150 313.454545454545 283 3.17762380859823e-17 56 2.02867380315039 2.20439677474774 1 25.9999486610026 150 283 95 56 246 481 441 468 584 125 519 146 M13376 GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of cardiac muscle tissue are generated and organized. 43/112 Gene Ontology BP GO:0055008 3.91777772279238e-19 3.14861262190463e-17 200 371.727272727273 284 3.56161611162942e-20 54 3.34890053554923 3.76409614062369 1 51.2985198479135 198 342 54 123 284 536 554 1002 244 117 635 147 M13335 GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. 51/122 Gene Ontology BP GO:0031032 1.75941392090964e-12 4.4884389202107e-11 125 341.636363636364 285 1.59946720082823e-13 122 2.52050512092434 2.82254918631772 1 24.2108001211854 151 123 168 122 951 285 429 480 373 183 493 148 M16921 GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 204/508 Gene Ontology BP GO:0031346 1.83738431226759e-09 2.69967574742355e-08 210 317.454545454545 285 1.67034937618374e-10 93 1.8807208262653 2.16852942007218 1 13.2133851712674 210 285 261 415 310 156 295 93 1026 321 120 149 M15276 GO_SENSORY_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_MORPHOGENESIS.html Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 133/407 Gene Ontology BP GO:0090596 7.97204303709344e-16 3.42724035381712e-14 100 336.454545454545 287 7.24731185190309e-17 95 2.11643725945263 2.37443057204978 1 26.4534721416415 95 302 99 266 287 242 394 451 1073 97 395 150 M12995 GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of cell junction assembly. 21/50 Gene Ontology BP GO:1901890 1.22145367481757e-08 7.68916604102299e-08 170 482.545454545455 290 1.11041243781741e-09 119 2.96798821207063 2.86693875201494 1 19.5998407379516 170 180 303 223 2063 290 119 640 155 478 687 151 M12873 GO_CEREBRAL_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_DEVELOPMENT.html The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. 65/190 Gene Ontology BP GO:0021987 2.0742998016755e-08 1.05829926808989e-07 255 384.272727272727 291 1.8857271102121e-09 38 2.37018022196648 2.65805952752129 1 15.3468445582474 254 921 359 233 766 258 291 84 527 496 38 152 M11503 GO_KIDNEY_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 68/192 Gene Ontology BP GO:0072073 4.01249924279406e-12 9.60311030118186e-11 475 420.090909090909 293 3.64772658436488e-13 24 2.20199135470308 2.29625535603988 1 20.4761318435466 473 106 180 37 24 768 515 1338 293 213 674 153 M15144 GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 80/237 Gene Ontology BP GO:0070374 9.45968834934483e-10 1.6029683578835e-08 225 502.090909090909 293 8.59971668492033e-11 57 2.00908466528707 2.24599877214037 1 14.5374313170986 222 909 247 681 57 293 205 475 1890 176 368 154 M10308 GO_BODY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_MORPHOGENESIS.html The process in which the anatomical structures of the soma are generated and organized. 34/79 Gene Ontology BP GO:0010171 3.45520818862392e-08 1.51059619771948e-07 115 374.272727272727 294 3.14109840262698e-09 108 2.50795029085895 2.82821367255023 1 15.8791284747666 112 357 533 449 956 123 108 137 294 821 227 155 M12990 GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 136/352 Gene Ontology BP GO:0070372 1.18791972383318e-09 1.93526711500262e-08 135 473.636363636364 294 1.07992702224965e-10 12 1.79297546876888 1.94686132621208 1 12.8375279530591 135 763 380 812 12 131 220 204 1917 342 294 156 M14014 GO_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYSTEM_PROCESS.html A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. 606/2821 Gene Ontology BP GO:0003008 8.16796289425517e-21 8.61905720864244e-19 145 725 295 8.16796289425516e-22 4 2.06907791189582 2.29236306844705 1 34.6954797410148 144 252 4170 108 537 140 501 493 1331 4 295 157 M15304 GO_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 96/277 Gene Ontology BP GO:0048863 4.09184822576978e-16 1.80937631545229e-14 1085 466.727272727273 295 3.71986202342705e-17 96 2.14917120056523 2.40277994281534 1 27.4160563207912 138 1021 96 311 1084 295 284 393 1082 180 250 158 M13039 GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. 57/171 Gene Ontology BP GO:0071774 1.39733065147022e-09 2.20673680774702e-08 300 681.454545454545 296 1.27030059305249e-10 19 2.17013570218833 2.43290391473918 1 15.4231152480719 296 2908 608 731 19 284 178 189 788 1342 153 159 M13349 GO_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFIBRIL_ASSEMBLY.html Formation of myofibrils, the repeating units of striated muscle. 34/82 Gene Ontology BP GO:0030239 6.32862478487956e-15 2.38892722570698e-13 695 341.909090909091 296 5.75329525898143e-16 114 2.71264536530887 2.96861257890181 1 31.7821559026824 120 145 114 249 301 443 575 694 296 132 692 160 M13921 GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. 33/112 Gene Ontology BP GO:0031644 9.834898350336e-09 6.79558232834488e-08 65 502.363636363636 299 8.94081672209276e-10 64 2.931362094876 2.95776533309582 1 19.5039631576426 64 1455 299 180 1306 122 138 574 678 621 89 161 M16051 GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE.html The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. 89/250 Gene Ontology BP GO:0048754 5.72032489519216e-17 2.82547537110395e-15 300 338 299 5.20029535926559e-18 85 2.41693047989471 2.75788556107418 1 32.6410191256077 299 89 85 153 215 712 589 534 342 172 528 162 M10820 GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 208/544 Gene Ontology BP GO:0010769 3.55137826525894e-15 1.36273134591713e-13 155 328.909090909091 303 3.22852569568994e-16 112 2.00547340866635 2.27497488712057 1 23.9505640268629 154 470 112 362 601 244 401 184 646 141 303 163 M16302 GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 79/167 Gene Ontology BP GO:0071260 1.81014902653818e-08 9.79548010514773e-08 315 420 304 1.64559003766545e-09 103 2.18804513157061 2.49874866779745 1 14.2357344312607 314 103 622 246 709 219 304 151 934 910 108 164 M14576 GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of adherens junction organization. 20/47 Gene Ontology BP GO:1903393 1.56505920202021e-08 8.86167057924368e-08 210 488.090909090909 306 1.42278110286717e-09 125 3.11108318653103 3.01385604596668 1 20.3668045513201 208 389 306 219 1896 277 125 592 146 564 647 165 M10469 GO_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_PRESSURE.html Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 89/298 Gene Ontology BP GO:0008217 1.04620709773215e-16 5.00777273687665e-15 30 418.909090909091 307 9.51097361574679e-18 28 2.74992160356545 2.83575498026388 1 36.5036492883251 28 776 88 337 1658 85 135 472 571 151 307 166 M13795 GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 9/15 Gene Ontology BP GO:0030207 1.79799581429183e-08 9.77436154800475e-08 290 903.454545454545 307 1.79799582883938e-09 8 1.955850813086 1.955850813086 1 12.7267467308351 287 234 4133 1579 1484 63 8 307 685 1138 20 167 M11553 GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 113/320 Gene Ontology BP GO:0071229 7.50058037967527e-15 2.74214131518364e-13 290 530.636363636364 308 6.81870943606845e-16 117 2.18935763288482 2.38298585631608 1 25.5294543031366 288 308 117 221 176 983 815 649 1213 218 849 168 M15889 GO_SKIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_DEVELOPMENT.html The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. 118/353 Gene Ontology BP GO:0043588 6.49350184027626e-19 4.86279500716172e-17 265 342.818181818182 308 5.90318349116022e-20 59 2.34393712629258 2.55669832419501 1 35.4937568557909 262 488 59 318 584 308 446 228 750 87 241 169 M11847 GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 52/124 Gene Ontology BP GO:0006023 1.68462250246741e-08 9.32227361461289e-08 310 583.272727272727 309 1.53147501397018e-09 66 2.01587227941368 2.09109158916495 1 13.155792394608 66 791 308 1303 1112 309 277 72 1339 249 590 170 M12483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. 16/34 Gene Ontology BP GO:0014912 2.72480168886164e-07 7.33831452516508e-07 310 818.090909090909 309 2.47709275121908e-08 29 2.1235775391504 2.36465005852351 1 12.0923193957133 309 2238 1259 434 2261 170 29 180 302 1681 136 171 M16055 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 23/54 Gene Ontology BP GO:0060999 3.38117716787266e-08 1.48381905391614e-07 90 612.909090909091 310 3.07379747257995e-09 57 2.0222717417829 2.1575963440905 1 12.8186277032809 90 949 1105 1407 1261 97 57 71 310 1281 114 172 M10034 GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. 3/22 Gene Ontology BP GO:0042053 1.0114546713405e-07 3.30540455370318e-07 1695 1023.63636363636 311 1.01145471737733e-08 6 2.90456802128973 4.01752307891935 1 17.4734096204126 1693 247 3520 156 1436 1719 311 114 6 1754 304 173 M12440 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD.html The morphogenetic process in which an epithelial sheet bends along a linear axis. 11/25 Gene Ontology BP GO:0060571 1.32271751416785e-08 8.1342747262004e-08 370 545.454545454545 311 1.20247047465499e-09 58 2.53478987234398 2.94346427596331 1 16.6816039000774 370 970 1002 106 590 262 120 58 194 2017 311 174 M13079 GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 41/98 Gene Ontology BP GO:0060998 3.36598820575563e-08 1.47995106432987e-07 100 565.090909090909 312 3.05998932477733e-09 25 2.15153179636363 2.24647798206621 1 13.6402358421823 96 1725 804 1108 948 106 25 104 312 825 163 175 M15930 GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. 3/22 Gene Ontology BP GO:0042069 9.31361187281059e-08 3.09100070946816e-07 1695 1111.81818181818 312 9.31361226315576e-09 7 2.90456802128973 4.01752307891935 1 17.5519375824591 1694 248 4481 157 1437 1720 312 108 7 1761 305 176 M16902 GO_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a synapse. 39/123 Gene Ontology BP GO:0007416 1.01204307120829e-08 6.89872442732571e-08 490 340.636363636364 313 9.2003915987626e-10 127 1.89910676790311 1.89802514290419 1 12.6242681871881 127 144 486 313 488 302 260 503 445 211 468 177 M13461 GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of dendrite development. 48/107 Gene Ontology BP GO:1900006 4.74682403384846e-08 1.89668709028902e-07 85 497.181818181818 318 4.31529466933472e-09 56 1.96249409165459 2.16607298291869 1 12.2454931484138 83 1038 787 874 1060 114 56 119 318 827 193 178 M13908 GO_NEUROGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROGENESIS.html Generation of cells within the nervous system. 683/1999 Gene Ontology BP GO:0022008 6.93711628449163e-15 2.55627229435672e-13 320 756.454545454545 318 6.93711628449166e-16 17 1.86435604233893 2.17639996800869 1 21.7924600326866 318 452 4153 302 200 468 656 283 1230 17 242 179 M14962 GO_ENDODERM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_FORMATION.html The formation of the endoderm during gastrulation. 37/84 Gene Ontology BP GO:0001706 5.35118410458022e-10 9.59287559751581e-09 155 433.454545454545 318 4.86471282352892e-11 143 2.44075748369808 2.67329902528958 1 18.1661372652925 153 143 238 193 1561 318 181 545 504 436 496 180 M11226 GO_MORPHOGENESIS_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIUM.html The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. 242/611 Gene Ontology BP GO:0002009 5.35739602981094e-21 5.92247375390767e-19 45 375.545454545455 319 4.87036002710085e-22 36 2.03754180605238 2.1926302399083 1 34.4748749836848 241 43 41 36 319 611 688 684 867 70 531 181 M15828 GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. 80/235 Gene Ontology BP GO:0060041 5.68407200251453e-12 1.32618825666708e-10 220 334.090909090909 320 5.16733818411746e-13 126 2.25059938603633 2.59066745561341 1 20.635250621011 218 320 185 431 583 367 259 199 496 126 491 182 M12903 GO_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 221/509 Gene Ontology BP GO:0070482 4.55056579663673e-14 1.48790683054819e-12 325 386.454545454545 322 4.13687799694255e-15 49 1.96431623589916 2.21304048112729 1 21.5660555797756 325 280 132 283 49 363 569 496 1323 109 322 183 M13804 GO_EPIBOLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIBOLY.html The expansion of one cell sheet over other cells or yolk. 23/53 Gene Ontology BP GO:0090504 8.9895741167122e-09 6.49122746872391e-08 310 335.545454545455 323 8.17234013949559e-10 149 2.81631200570675 2.91051894100635 1 18.790495190091 306 173 300 389 440 149 398 637 323 341 235 184 M11392 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE.html A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. 14/27 Gene Ontology BP GO:0035584 1.27554275694892e-06 2.75074083628139e-06 695 647.272727272727 325 1.15958499681747e-07 57 2.84987124768614 2.84987124768614 1 14.709982350128 209 695 695 64 2557 325 480 312 57 1413 313 185 M14078 GO_CELLULAR_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 37/74 Gene Ontology BP GO:0031670 1.69057815711912e-08 9.32227361461289e-08 150 404.909090909091 325 1.5368892455548e-09 142 2.27092743538551 2.45080283503909 1 14.8203089254449 142 149 325 824 689 159 406 146 1004 353 257 186 M16002 GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rho protein signal transduction. 57/144 Gene Ontology BP GO:0035023 1.01664743047007e-09 1.69186165579661e-08 160 436.181818181818 326 9.24224937218072e-11 113 2.40600699512669 2.63431582015735 1 17.3571504056018 158 113 249 145 359 1061 714 408 326 240 1025 187 M14813 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. 560/1430 Gene Ontology BP GO:0022603 3.6653608814972e-13 1.03769942517021e-11 205 716.636363636364 327 3.66536088149779e-14 25 1.87065926475323 2.15412222891597 1 19.0731103297927 201 254 4297 408 186 376 514 102 1193 25 327 188 M16052 GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Ras protein signal transduction. 98/239 Gene Ontology BP GO:0046578 5.75741011135456e-10 1.02814058257766e-08 330 517.818181818182 329 5.23400919351026e-11 8 2.18283449704102 2.44721273743644 1 16.1854637408574 329 84 239 146 8 1304 846 652 556 299 1233 189 M12413 GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 42/99 Gene Ontology BP GO:0070167 6.00015921542463e-09 5.15902578466973e-08 350 387 330 5.45469021071739e-10 82 2.28282206714178 2.46910941316306 1 15.4424332175749 516 350 347 265 293 747 708 82 317 330 302 190 M16556 GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/22 Gene Ontology BP GO:0051957 7.49783809596782e-09 5.86332115310401e-08 330 450.090909090909 330 6.81621647411026e-10 30 3.07333693675735 3.47379282540557 1 20.6314191575503 330 221 657 46 1340 539 297 30 38 1013 440 191 M10268 GO_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 497/1356 Gene Ontology BP GO:0060429 7.98740625242162e-38 9.2713818074984e-35 15 338.727272727273 331 7.2612784112924e-39 4 2.02976128267758 2.20100578410844 1 64.1228025293817 331 15 4 4 163 462 747 516 978 12 494 192 M12172 GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. 40/92 Gene Ontology BP GO:0001954 6.96267549852455e-10 1.21991329583583e-08 245 358.636363636364 331 6.32970500066196e-11 145 2.55363655810498 2.83593865410583 1 18.7588503020595 265 348 243 218 704 331 145 498 241 357 595 193 M12096 GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 58/202 Gene Ontology BP GO:0030799 2.87911303889538e-09 3.65029676110884e-08 240 524.090909090909 332 2.61737549333023e-10 92 2.08725620192442 2.17870482687859 1 14.4105948505655 239 646 332 875 92 138 124 745 2124 350 100 194 M11371 GO_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). 238/666 Gene Ontology BP GO:0001501 2.33288332241747e-16 1.08315772659843e-14 245 391.272727272727 335 2.12080302037952e-17 60 2.0284748937456 2.1944770508513 1 26.2959765239527 119 897 91 367 387 245 426 242 1135 60 335 195 M10963 GO_POSITIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LOCOMOTION.html Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. 278/658 Gene Ontology BP GO:0040017 3.59307165428719e-20 3.62665906322944e-18 340 446.545454545455 336 3.26642877662472e-21 44 1.90736202737376 2.13293522063698 1 30.8788441508425 123 464 44 324 697 336 375 336 1596 65 552 196 M12114 GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of epithelial cell proliferation. 173/422 Gene Ontology BP GO:0050678 5.86482513265629e-14 1.89099882575855e-12 340 418 337 5.33165921150584e-15 58 2.01717172581283 2.29293867208774 1 21.9513994610729 337 58 134 62 929 590 773 234 786 161 534 197 M14110 GO_BLOOD_VESSEL_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_REMODELING.html The reorganization or renovation of existing blood vessels. 20/45 Gene Ontology BP GO:0001974 2.73403278932216e-08 1.28555726231123e-07 395 470 337 2.4854843848174e-09 68 2.62253368487944 2.86020494406245 1 16.7751611159735 217 392 395 162 1852 337 320 68 371 744 312 198 M16144 GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 75/173 Gene Ontology BP GO:0010811 2.96647869931512e-13 8.62729129285618e-12 230 387.727272727273 337 2.69679881755956e-14 96 2.20290987238402 2.49747396331659 1 22.6247069360768 226 96 148 323 713 589 379 337 518 187 749 199 M12477 GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 53/128 Gene Ontology BP GO:0071300 1.06438691696926e-13 3.23003167025377e-12 75 329.727272727273 338 9.67624469972099e-15 73 2.47945291446307 2.60209743280154 1 26.4469146507088 73 510 142 208 648 338 282 363 403 171 489 200 M15398 GO_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_GROWTH.html The increase in size or mass of the heart. 20/43 Gene Ontology BP GO:0060419 1.70875118892611e-08 9.38903168069103e-08 175 565.272727272727 338 1.55341018381643e-09 49 2.23780326890958 2.39869312259488 1 14.5976998165953 173 954 1031 560 1529 76 49 54 338 1356 98 201 M15950 GO_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 125/310 Gene Ontology BP GO:0007584 3.05916436931624e-13 8.82217401660578e-12 600 530.454545454545 338 2.78105851756061e-14 112 2.21312791992433 2.63695568098942 1 22.7097204703395 598 305 150 264 187 1397 855 112 935 338 694 202 M13393 GO_MUSCLE_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_MORPHOGENESIS.html The process in which the anatomical structures of muscle are generated and organized. 51/133 Gene Ontology BP GO:0048644 8.11789200691795e-19 5.88927696689376e-17 340 352.727272727273 339 7.37990182447085e-20 61 3.20840778378404 3.51589753297917 1 48.3365403666092 146 336 61 127 426 467 604 828 339 120 426 203 M11811 GO_FOREBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 187/610 Gene Ontology BP GO:0030900 1.61668612089945e-13 4.81171388418984e-12 80 384.454545454545 341 1.46971465536325e-14 79 2.17388490237002 2.44492318577563 1 22.8383050995804 397 1006 145 79 341 279 481 80 922 371 128 204 M15266 GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 13/33 Gene Ontology BP GO:0060317 3.56518015923478e-09 3.98870630704176e-08 345 707.909090909091 341 3.24107287728389e-10 13 1.92440998169396 1.92440998169396 1 13.2175091921108 341 1249 1130 1872 127 90 21 167 992 1785 13 205 M10301 GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 204/507 Gene Ontology BP GO:0010721 2.5377478368355e-14 8.66379647531415e-13 815 466.818181818182 344 2.3070434880323e-15 126 2.04711115108739 2.38124357224213 1 22.9213604761082 302 615 126 320 344 815 814 338 703 217 541 206 M11039 GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of vasculature development. 88/200 Gene Ontology BP GO:1904018 2.28675841346472e-09 3.16937889961692e-08 115 571.272727272727 345 2.07887128712877e-10 114 2.00785791015943 2.19182182402667 1 13.9767746096561 114 1287 265 952 167 281 345 491 1803 191 388 207 M14319 GO_OLFACTORY_LOBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_LOBE_DEVELOPMENT.html The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. 16/61 Gene Ontology BP GO:0021988 4.20871883016617e-09 4.33283404178748e-08 180 469.363636363636 345 3.82610803474334e-10 160 2.14515339131404 2.19496425783544 1 14.6620850284085 590 559 942 345 179 304 261 177 379 1267 160 208 M10944 GO_PEPTIDE_CROSS_LINKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CROSS_LINKING.html The formation of a covalent cross-link between or within protein chains. 22/103 Gene Ontology BP GO:0018149 9.03773924470647e-13 2.41162202949265e-11 515 497.181818181818 347 8.21612658610016e-14 121 2.78884499660546 3.19586067525863 1 27.4867623936592 512 168 160 143 954 950 347 1010 190 121 914 209 M11696 GO_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that modulates the frequency, rate, or extent of leukocyte migration. 73/208 Gene Ontology BP GO:0002685 2.37022541060641e-08 1.16228070309752e-07 350 656 347 2.15475039649329e-09 107 1.87291976622884 2.10463298946251 1 12.0563346790329 347 107 316 1396 867 322 343 492 2198 248 580 210 M16913 GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 113/273 Gene Ontology BP GO:0010770 5.84294827293013e-08 2.19666468268944e-07 135 492.636363636364 348 5.31177129828376e-09 111 2.00571246147277 2.37026478366385 1 12.3964407110463 133 1119 348 611 1140 164 322 111 718 601 152 211 M12140 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. 74/160 Gene Ontology BP GO:2001237 1.32762574627497e-08 8.14288816374465e-08 350 369.272727272727 349 1.20693250389704e-09 29 2.07272112961903 2.43846460757674 1 13.6398174584911 404 500 351 349 591 165 271 63 993 346 29 212 M11359 GO_ARTERY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_DEVELOPMENT.html The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. 56/156 Gene Ontology BP GO:0060840 2.90729402495316e-12 7.06731212453274e-11 115 318.545454545455 350 2.64299456814273e-13 113 2.36071639588824 2.70206503926902 1 22.2438984446517 113 115 177 187 437 477 350 377 416 301 554 213 M13152 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 738/1994 Gene Ontology BP GO:0051240 1.22451395877798e-17 6.768355131674e-16 10 718.363636363636 350 1.22451395877798e-18 7 1.92462786225585 2.17398802786216 1 27.1011460519301 207 7 4024 115 531 412 445 279 1522 10 350 214 M10490 GO_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 37/113 Gene Ontology BP GO:0001656 6.69504746445526e-09 5.50177850965416e-08 330 972.636363636364 351 6.08640680439058e-10 268 2.17672146787937 2.37521387384861 1 14.6682573423034 1245 351 330 268 330 2056 1634 1907 295 281 2002 215 M16122 GO_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. 70/195 Gene Ontology BP GO:0055001 3.48629576709109e-12 8.38697992052018e-11 185 468.727272727273 351 3.16935978826965e-13 140 2.54478588824807 2.90253226183815 1 23.8026627901671 181 1032 179 140 669 301 351 797 542 283 681 216 M11740 GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 169/414 Gene Ontology BP GO:0051961 5.14648387693846e-13 1.42232884765627e-11 155 410 352 4.6786217063088e-14 154 2.0960144821732 2.48959540132331 1 21.1044022774212 294 475 155 154 496 685 851 233 536 279 352 217 M12499 GO_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPROUTING_ANGIOGENESIS.html The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. 25/83 Gene Ontology BP GO:0002040 8.22261856355627e-08 2.80717779342587e-07 120 581.909090909091 353 7.47510806443738e-09 52 2.18533405334081 2.22393561740604 1 13.2905503727507 116 1383 637 353 1274 74 66 288 1006 1152 52 218 M12511 GO_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 47/116 Gene Ontology BP GO:0006029 2.42412138687426e-08 1.18142693525154e-07 610 423 354 2.20374673962274e-09 62 2.198387979798 2.38345652297703 1 14.1369541591847 91 343 354 908 832 153 62 610 610 370 320 219 M16562 GO_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. 767/2129 Gene Ontology BP GO:0009888 9.18748944528562e-24 1.64067359594081e-21 5 740.090909090909 354 9.18748944528566e-25 3 2.02106698994148 2.18663854774874 1 38.99414605196 141 4 4581 355 285 210 521 488 1199 3 354 220 M16715 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 14/21 Gene Ontology BP GO:0010664 1.05102937613002e-08 7.00133341947155e-08 510 475.363636363636 356 9.55481255592012e-10 4 2.44092466571556 2.82884445168135 1 16.2114618618994 507 418 864 286 1362 356 180 67 158 1027 4 221 M10152 GO_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of neurological system. 333/2079 Gene Ontology BP GO:0050877 2.19052205427256e-17 1.16903378137787e-15 285 565.454545454545 357 1.99138368570232e-18 80 1.98601436416909 2.22093236217411 1 27.5279921285784 283 1272 80 790 694 324 709 302 1302 107 357 222 M14237 GO_REGULATION_OF_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. 248/729 Gene Ontology BP GO:0044057 3.31026874609202e-17 1.72691885259609e-15 105 465.818181818182 359 3.00933522372001e-18 74 2.0019335166925 2.08190738663091 1 27.4337647255135 103 756 81 414 743 148 359 591 1617 74 238 223 M15345 GO_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. 19/91 Gene Ontology BP GO:0048663 3.84316076338497e-09 4.15796396971137e-08 240 364.272727272727 359 3.4937825182714e-10 64 2.38099281507641 2.66433961352878 1 16.3135863189931 236 396 572 199 154 422 559 141 359 905 64 224 M10841 GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 247/769 Gene Ontology BP GO:0071407 4.3521015567625e-12 1.03095956775757e-10 260 519.272727272727 360 3.956455960701e-13 46 2.0633453216819 2.23933178780229 1 19.1278253325516 257 1713 182 566 424 118 360 157 1446 443 46 225 M16015 GO_AMINOGLYCAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 30/79 Gene Ontology BP GO:0006026 3.23539126063507e-09 3.84357595519315e-08 365 428.181818181818 360 2.94126478672104e-10 17 2.05885689620002 2.53303179824525 1 14.1716998652149 362 159 591 1121 212 360 341 17 737 763 47 226 M10898 GO_OTIC_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OTIC_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. 15/42 Gene Ontology BP GO:0071599 3.55345603940821e-11 7.39851856097414e-10 290 503.727272727273 362 3.23041458133237e-12 189 2.83951148955379 3.26913625345901 1 24.0671256906242 290 398 207 205 1754 489 362 603 189 223 821 227 M10455 GO_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. 152/408 Gene Ontology BP GO:0007517 3.93322274543331e-19 3.14861262190463e-17 135 369.909090909091 364 3.57565704130299e-20 55 2.34720000569459 2.71868725139836 1 35.9544526917921 132 480 55 496 433 335 570 323 745 136 364 228 M14608 GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. 28/84 Gene Ontology BP GO:0007157 2.73835048982512e-08 1.28555726231123e-07 250 399.181818181818 367 2.48940956719045e-09 236 2.28093250505705 2.40156268192748 1 14.5900929387327 248 367 318 357 872 368 249 373 236 424 579 229 M15042 GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of muscle tissue development. 33/88 Gene Ontology BP GO:1901863 2.71898658947263e-09 3.55203396742438e-08 305 466.636363636364 367 2.47180599348457e-10 68 2.31835706351701 2.56097836337446 1 16.0316388434592 304 673 558 299 76 321 367 438 1268 761 68 230 M15789 GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cell differentiation. 460/1237 Gene Ontology BP GO:0045597 4.72725930469063e-24 9.14527706319941e-22 25 431.909090909091 371 4.29750845880964e-25 23 1.91840708802935 2.19271186804451 1 37.4654488561987 401 23 24 119 371 928 836 248 1262 32 507 231 M12444 GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 325/835 Gene Ontology BP GO:0031344 1.97192812455937e-12 4.92239907652104e-11 395 427.818181818182 372 1.79266193141921e-13 158 1.83349583425782 2.10524855456383 1 17.5434912592493 393 461 172 309 208 561 625 372 1087 158 360 232 M13343 GO_PALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. 98/287 Gene Ontology BP GO:0021543 1.63780774591443e-08 9.12886118160949e-08 375 450 372 1.48891614373384e-09 25 2.32788795159559 2.57671840314164 1 15.2117145531038 372 1284 414 237 806 158 352 52 548 702 25 233 M13415 GO_BLOOD_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. 220/539 Gene Ontology BP GO:0048514 3.08723917698667e-24 6.23219630380397e-22 55 443.454545454545 372 2.80658106998788e-25 23 2.1502771381578 2.25696247905916 1 42.3261926611413 55 49 23 363 771 488 372 854 1188 42 673 234 M11140 GO_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING.html Any process that mediates the transfer of information from one cell to another. 311/1050 Gene Ontology BP GO:0007267 2.27789193042577e-21 2.64406305824171e-19 170 502.818181818182 373 2.07081084584161e-22 28 1.99239655299376 2.15144442014335 1 34.3587634808696 166 894 39 743 783 166 373 671 1476 28 192 235 M10470 GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. 25/70 Gene Ontology BP GO:0060688 7.91882030566284e-08 2.71945877804679e-07 365 558 376 7.19892780972537e-09 62 2.04948398657741 2.24040327930512 1 12.4905806839723 361 376 468 76 1267 218 126 2162 601 421 62 236 M11151 GO_POSITIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. 254/658 Gene Ontology BP GO:0043410 2.1184928692662e-11 4.63969924151084e-10 280 530 376 1.92590260844237e-12 165 1.83400043634899 2.09501252944565 1 15.8896223860548 277 612 197 466 781 271 376 669 1698 165 318 237 M14849 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. 161/358 Gene Ontology BP GO:2000116 6.34458838107922e-09 5.36574204979067e-08 30 443.818181818182 376 5.76780763579672e-10 27 1.73458336681284 2.10014473981229 1 11.7063320323797 376 295 543 488 308 195 430 28 1312 880 27 238 M14884 GO_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ASSEMBLY.html A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. 102/211 Gene Ontology BP GO:0034329 2.38980811404457e-15 9.56541299440426e-14 300 504 379 2.1725528309496e-16 107 2.34528759166406 2.73137953564265 1 28.3434528132837 298 629 107 303 1349 328 582 588 806 175 379 239 M16923 GO_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSSIFICATION.html Any process that modulates the frequency, rate or extent of bone formation. 113/250 Gene Ontology BP GO:0030278 6.09227498629355e-09 5.19971190466194e-08 280 511.181818181818 379 5.53843182105854e-10 278 1.94759356604523 1.82375731803876 1 13.1685706803156 278 489 344 379 298 430 615 994 1142 280 374 240 M13215 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). 248/1835 Gene Ontology BP GO:0007186 9.68066620284783e-17 4.731298229455e-15 110 784 381 8.80060563895253e-18 86 1.96331282817851 2.0806986104339 1 26.1068137147262 106 1884 86 1792 381 300 306 947 2217 103 502 241 M12404 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 249/586 Gene Ontology BP GO:0044089 7.36494313202059e-11 1.48675786791181e-09 635 591.636363636364 382 6.69540284751561e-12 44 1.93299684523377 2.36238222116014 1 15.8398398869543 633 44 213 66 382 1755 1025 162 874 250 1104 242 M15882 GO_NOTOCHORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTOCHORD_DEVELOPMENT.html The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. 24/52 Gene Ontology BP GO:0030903 1.0574273527664e-07 3.41658677724036e-07 310 525.454545454545 382 9.61297639628661e-09 91 2.80442763087421 3.14547149671451 1 16.833578433194 310 1382 372 401 1354 439 323 295 91 382 431 243 M10805 GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION.html Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 13/28 Gene Ontology BP GO:0010544 4.46167943426176e-09 4.47420682792168e-08 670 576.545454545455 386 4.05607222119111e-10 152 2.71103261531951 2.76007617572757 1 18.4947688070985 152 693 283 711 2067 226 170 666 669 319 386 244 M15599 GO_KIDNEY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MORPHOGENESIS.html Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 38/117 Gene Ontology BP GO:0060993 1.12702171108417e-09 1.85558929239851e-08 965 792.909090909091 386 1.02456519241957e-10 10 2.16045685621925 2.22336815490388 1 15.5052764488813 965 137 386 61 10 1627 1146 2326 200 373 1491 245 M15968 GO_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. 64/190 Gene Ontology BP GO:0048593 7.86525182574302e-09 6.00371670427235e-08 325 434.181818181818 386 7.15022895805656e-10 189 2.0521633701045 2.26053249296469 1 13.7566688298311 321 1034 418 189 386 313 326 612 492 402 283 246 M13006 GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS.html The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 78/326 Gene Ontology BP GO:0050953 8.14561782281665e-08 2.78498553397185e-07 445 487.545454545455 388 7.40510738582956e-09 231 2.05227635069733 2.54899738647921 1 12.487899711303 442 322 368 866 1272 491 411 244 388 231 328 247 M10808 GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. 55/184 Gene Ontology BP GO:0048706 3.11799115158868e-10 5.76766251666384e-09 365 564.636363636364 390 2.83453741093688e-11 232 2.33927215039047 2.68481090583192 1 17.8905791231274 364 331 232 390 273 1110 761 647 716 251 1136 248 M11608 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. 17/45 Gene Ontology BP GO:0060043 5.47698323802926e-09 4.97122471997677e-08 380 522.272727272727 390 4.9790756833313e-10 202 3.01961877667157 3.20184354903147 1 20.4717262465414 379 959 512 344 260 681 293 988 202 737 390 249 M11002 GO_SINGLE_ORGANISM_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELL_ADHESION.html The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. 262/734 Gene Ontology BP GO:0098602 7.34609514095818e-24 1.36431678957875e-21 40 406.090909090909 392 6.67826830996196e-25 13 2.15764492860127 2.46379127633592 1 41.7897016507193 392 39 25 13 741 770 742 285 944 38 478 250 M12057 GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 48/106 Gene Ontology BP GO:0010812 4.5515315524506e-08 1.84404546230612e-07 75 449.727272727273 393 4.13775604237841e-09 75 2.20994294896992 2.40570959973344 1 13.8145912213667 75 341 393 605 1042 327 128 379 756 482 419 251 M16349 GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 461/1347 Gene Ontology BP GO:0007417 4.5989092923518e-18 2.702877954986e-16 75 531.909090909091 394 4.18082662941071e-19 39 2.00745231831942 2.40519481949788 1 29.0102881479701 769 259 73 39 75 1273 1123 751 1011 84 394 252 M11618 GO_CRANIAL_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 25/92 Gene Ontology BP GO:0021545 1.67041274557107e-07 4.92427071599142e-07 315 637.545454545455 395 1.51855715672903e-08 234 2.19485050023184 2.59804137597696 1 12.8511568092382 315 1229 734 539 1498 311 276 395 331 1151 234 253 M12173 GO_EMBRYO_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT.html The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. 469/1244 Gene Ontology BP GO:0009790 8.42773648771595e-14 2.60866536749768e-12 395 564.727272727273 395 7.66157862519659e-15 67 1.87085283252554 2.04335184382671 1 20.1164631984762 395 258 139 369 67 879 804 677 1641 271 712 254 M14026 GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT.html The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. 642/1793 Gene Ontology BP GO:0006928 3.07056398177343e-18 1.9008838089832e-16 215 819 396 3.07056398177344e-19 9 2.00805283510431 2.1947289258573 1 29.3039166159899 215 888 4173 356 350 393 460 429 1340 9 396 255 M15797 GO_ADENOHYPOPHYSIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOHYPOPHYSIS_DEVELOPMENT.html The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. 3/17 Gene Ontology BP GO:0021984 1.23507936682895e-08 7.72840094364798e-08 10 1053 396 1.23507937369334e-09 8 2.52428877881546 -2.52428877881546 -1 16.6645828735537 1033 1105 4459 396 1256 315 93 46 10 2862 8 256 M13575 GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. 51/151 Gene Ontology BP GO:1901343 6.11248500308211e-12 1.40496375590645e-10 40 622.545454545455 399 5.55680454827191e-13 39 2.53858418174283 2.57448669120118 1 23.2166670400404 39 1294 188 754 2293 233 174 308 734 399 432 257 M16290 GO_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of dendrite development. 76/194 Gene Ontology BP GO:0050773 6.33964763721507e-08 2.31043830295052e-07 585 523 402 5.76331619991093e-09 114 2.0205925186061 2.25273865640881 1 12.4472741320141 157 1442 581 720 1177 144 114 222 402 585 209 258 M13078 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of multicellular organismal development. 850/2329 Gene Ontology BP GO:2000026 3.91554623982233e-19 3.14861262190463e-17 390 779.090909090909 405 3.91554623982233e-20 1 1.8585973918325 2.08357509625032 1 28.4700288582095 386 1 4007 248 415 643 704 243 1512 6 405 259 M13531 GO_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SIZE.html Any process that modulates the size of a cell. 113/258 Gene Ontology BP GO:0008361 4.56123299123991e-08 1.84611140888591e-07 225 664.363636363636 405 4.14657553255218e-09 44 2.03072048598107 2.23816865678261 1 12.6933356404856 225 1770 405 989 1043 51 215 332 1533 701 44 260 M16048 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 18/29 Gene Ontology BP GO:0010662 9.98027047192903e-08 3.27017613275699e-07 815 602.363636363636 405 9.07297356789334e-09 159 2.47563041954259 2.82884445168135 1 14.9036844324025 815 405 890 383 1334 764 325 159 211 1108 232 261 M16413 GO_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized. 93/279 Gene Ontology BP GO:0048705 5.58821512478558e-12 1.31040822345351e-10 315 392.636363636364 407 5.08019556799979e-13 87 2.19827618774864 2.48833146917241 1 20.1661187623613 313 87 184 460 267 667 465 407 746 159 564 262 M10722 GO_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that modulates the frequency, rate or extent of developmental growth. 164/478 Gene Ontology BP GO:0048638 7.27776118568472e-11 1.47557402555171e-09 250 431.454545454545 408 6.61614653265951e-12 212 2.18938070668319 2.51425684570343 1 17.947428283903 408 761 212 326 248 474 739 415 672 245 246 263 M16857 GO_REGULATION_OF_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. 325/834 Gene Ontology BP GO:0022604 1.18558511225699e-15 4.91488542518678e-14 325 458 410 1.07780464750635e-16 103 1.93523469432923 2.24378660708817 1 23.9073506602926 324 893 103 410 340 700 662 190 801 142 473 264 M11366 GO_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_ASSEMBLY.html The aggregation, arrangement and bonding together of the extracellular matrix. 14/22 Gene Ontology BP GO:0085029 1.98128227190513e-08 1.02898138573328e-07 415 450 412 1.80116571795293e-09 133 2.29072364728221 2.66559819760767 1 14.8583096283863 412 844 557 631 747 437 258 133 170 376 385 265 M15086 GO_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 7/21 Gene Ontology BP GO:0010463 1.40256435976449e-10 2.71337763432772e-09 360 835.454545454545 413 1.40256435985301e-11 3 2.45746585179231 2.66731261689844 1 19.5415734557472 360 726 4346 427 1860 272 413 3 95 510 178 266 M15295 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION.html The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. 26/73 Gene Ontology BP GO:0006929 1.33691522530872e-07 4.11624495431589e-07 300 765.909090909091 415 1.2153775514105e-08 67 2.1758235443496 2.2535506866392 1 12.896968352231 297 2387 975 740 1428 102 67 245 415 1578 191 267 M13402 GO_AMINOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 83/196 Gene Ontology BP GO:0006022 3.26289213207265e-09 3.84357595519315e-08 180 534.636363636364 417 2.96626557901087e-10 177 1.91929067206996 2.0788294085396 1 13.211025681498 177 495 276 1302 376 465 417 241 1420 204 508 268 M13507 GO_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASODILATION.html An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. 18/34 Gene Ontology BP GO:0042311 5.68152067264042e-09 5.04881982447536e-08 240 464.454545454545 419 5.16501880664819e-10 1 2.80783295483952 2.61563335255188 1 19.018376907481 238 1153 562 419 788 73 70 955 234 616 1 269 M14538 GO_CARDIOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. 58/192 Gene Ontology BP GO:0035051 9.08362936779911e-11 1.79469324062516e-09 420 510.909090909091 420 8.25784488015831e-12 217 2.63406632601212 2.95071992739369 1 21.3848300285998 272 1131 217 420 494 269 395 754 793 418 457 270 M15272 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. 15/52 Gene Ontology BP GO:0001937 3.0150141929255e-07 7.9717976202825e-07 270 564 420 2.74092236920137e-08 87 2.11320388589185 2.37281417216083 1 11.9627095071832 268 560 732 714 2203 312 87 192 124 592 420 271 M16534 GO_BIOLOGICAL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOLOGICAL_ADHESION.html The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. 492/1424 Gene Ontology BP GO:0022610 1.0354077043735e-54 4.80739797140615e-51 5 335.545454545455 420 9.41279731248638e-56 1 2.14095092120358 2.2902247557002 1 100 93 13 1 1 527 420 489 708 889 2 548 272 M13602 GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS.html The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. 53/145 Gene Ontology BP GO:0044236 2.35093708847369e-15 9.49165295807247e-14 120 421.454545454545 421 2.13721553497607e-16 106 2.44860652209641 2.60338453468688 1 29.5997321746353 117 118 106 498 224 647 421 775 892 143 695 273 M11139 GO_SECOND_MESSENGER_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECOND_MESSENGER_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. 99/251 Gene Ontology BP GO:0019932 3.84864434001606e-08 1.62743676417983e-07 65 707.909090909091 423 3.49876764303966e-09 65 2.16756298102562 2.18852150671707 1 13.6588589300247 65 1438 329 910 2095 137 224 847 982 423 337 274 M12997 GO_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_MORPHOGENESIS.html The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 149/374 Gene Ontology BP GO:0003007 2.46250874317237e-20 2.54076179878874e-18 480 318.454545454545 423 2.23864431197488e-21 42 2.22982606178647 2.450347064061 1 36.4191904587469 167 478 43 42 214 464 440 423 692 61 479 275 M13126 GO_NEURON_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. 7/44 Gene Ontology BP GO:0048665 1.40533520230213e-08 8.38685262762054e-08 425 881.272727272727 423 1.40533521118948e-09 51 2.83824223482492 3.28267233834688 1 18.6436538228615 423 1336 4017 692 1287 423 389 51 145 798 133 276 M16206 GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels. 458/1179 Gene Ontology BP GO:0072358 5.90216438031116e-32 4.56729153629745e-29 20 380 425 5.36560398210111e-33 5 2.02343887039226 2.18161641820792 1 53.2309607547256 71 19 5 21 483 425 457 727 1387 18 567 277 M13035 GO_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_GROWTH.html Any process that modulates the frequency, rate, extent or direction of cell growth. 238/558 Gene Ontology BP GO:0001558 3.211031125347e-08 1.43354014567174e-07 340 591.909090909091 426 2.91911924746718e-09 71 1.9973980089552 2.21680770533739 1 12.6887178337245 336 1111 324 1013 930 182 548 179 1391 426 71 278 M16442 GO_CIRCULATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. 458/1179 Gene Ontology BP GO:0072359 5.90216438031116e-32 4.56729153629745e-29 20 385.909090909091 426 5.36560398210111e-33 6 2.02343887039226 2.18161641820792 1 53.2309607547256 72 20 6 22 484 426 458 782 1388 19 568 279 M13755 GO_ENDODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. 46/113 Gene Ontology BP GO:0007492 4.07699790671442e-11 8.4131116803889e-10 245 494.454545454545 427 3.70636173344542e-12 73 2.4468055150955 2.75563448354466 1 20.611865352209 245 130 209 73 1319 716 349 682 560 427 729 280 M15342 GO_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_GROWTH.html Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 28/75 Gene Ontology BP GO:0060420 4.73200703409465e-08 1.89297589519312e-07 410 518.818181818182 427 4.30182466897816e-09 217 2.86921696305152 3.05660650136324 1 17.9054922953195 410 815 529 217 1058 533 278 345 249 846 427 281 M10687 GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. 31/54 Gene Ontology BP GO:0045599 1.37984705553672e-08 8.32189868277674e-08 415 422 429 1.25440642199197e-09 85 2.01619385796204 2.25429457159652 1 13.2501573811738 414 534 436 85 606 621 302 97 731 429 387 282 M11315 GO_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGENERATION.html The regrowth of a lost or destroyed body part, such as an organ or tissue. 104/245 Gene Ontology BP GO:0031099 5.58749133647034e-08 2.13105020665705e-07 240 515.636363636364 430 5.07953770761792e-09 81 1.94023744286175 2.03750153887878 1 12.0154878380379 237 492 430 276 1119 371 482 391 1347 446 81 283 M11417 GO_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELINATION.html Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 25/53 Gene Ontology BP GO:0031641 1.83714000962738e-08 9.90690019128912e-08 435 570.181818181818 431 1.67012729542606e-09 51 2.23813233565013 3.05296508043058 1 14.5514038140359 431 1147 902 93 712 445 232 340 76 1843 51 284 M10383 GO_EPIDERMIS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_MORPHOGENESIS.html The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 27/52 Gene Ontology BP GO:0048730 3.56614046934576e-07 9.21401791829292e-07 435 692.545454545455 432 3.2419464067342e-08 221 2.4842796049442 2.53450784379355 1 13.9183107976004 334 1604 431 839 1724 257 221 432 906 633 237 285 M10682 GO_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CYCLE.html The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. 47/143 Gene Ontology BP GO:0042633 4.05981198248816e-09 4.27430998519105e-08 905 590 433 3.69073817270911e-10 280 2.41775940940446 2.58432057871734 1 16.5385972726477 326 794 280 904 1202 416 433 419 902 305 509 286 M13884 GO_MOLTING_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLTING_CYCLE.html The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. 47/143 Gene Ontology BP GO:0042303 4.05981198248816e-09 4.27430998519105e-08 905 591.636363636364 434 3.69073817270911e-10 281 2.41775940940446 2.58432057871734 1 16.5385972726477 327 795 281 905 1203 417 434 426 903 307 510 287 M16560 GO_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_AGGREGATION.html The adhesion of one platelet to one or more other platelets via adhesion molecules. 30/83 Gene Ontology BP GO:0070527 4.98750935623529e-09 4.71210768370877e-08 310 455.545454545455 436 4.53409942503838e-10 188 2.71253672467367 2.99225328253328 1 18.448378467669 307 943 514 473 235 188 364 436 435 631 485 288 M10857 GO_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ACTIVATION.html A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. 90/224 Gene Ontology BP GO:0030168 2.13953312073592e-10 4.08800505332382e-09 350 529.363636363636 437 1.94503010994908e-11 224 2.33681991085853 2.66590377926903 1 18.1960909615382 346 316 224 437 795 748 716 349 585 385 922 289 M15914 GO_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. 269/738 Gene Ontology BP GO:0030855 3.77028814421413e-30 1.75054478535862e-27 40 350.727272727273 438 3.4275346765583e-31 8 2.2370931284716 2.40674301735967 1 55.5632718710554 438 37 10 8 114 540 813 630 617 39 612 290 M15274 GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that activates or increases the frequency, rate or extent of blood circulation. 44/135 Gene Ontology BP GO:1903524 7.59414264366623e-08 2.64116886101441e-07 285 756.636363636364 439 6.90376627800652e-09 248 2.19779497730785 2.14260632403281 1 13.420343704305 285 1040 439 807 1247 275 248 1526 1792 303 361 291 M15855 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. 35/82 Gene Ontology BP GO:0032233 5.19832543258069e-08 2.02141462392973e-07 160 549.363636363636 439 4.72575050491877e-09 156 2.18172875500974 2.11551066548278 1 13.5574482573526 656 355 722 194 1094 347 158 1049 156 873 439 292 M13107 GO_REGULATION_OF_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ORGANIZATION.html Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 69/183 Gene Ontology BP GO:0050807 8.94851648294259e-08 2.99552718315086e-07 105 524.181818181818 440 8.13501531538564e-09 102 2.03589873503256 2.07070837169804 1 12.3284294479138 102 1289 472 766 1301 127 148 103 653 440 365 293 M14273 GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 126/288 Gene Ontology BP GO:0010810 1.12496568338889e-11 2.52329259322445e-10 195 484.727272727273 440 1.02269607581331e-12 65 2.0541344916326 2.28443296693943 1 18.3012276596563 194 65 193 334 774 803 555 440 999 184 791 294 M12870 GO_POSITIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION.html Any process that activates or increases the frequency, rate or extent of cell adhesion. 225/579 Gene Ontology BP GO:0045785 3.20002369920192e-15 1.24854706179786e-13 445 546.363636363636 442 2.90911245381992e-16 47 1.98290806838009 2.33150488557687 1 23.7510298122543 358 47 110 74 443 1206 986 442 1225 156 963 295 M11423 GO_REGULATION_OF_DOPAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of dopamine. 5/27 Gene Ontology BP GO:0014059 1.39362076594714e-08 8.34913705328072e-08 390 772.909090909091 443 1.39362077468694e-09 50 3.41903079150579 3.41903079150579 1 22.4649108527107 387 443 3743 75 1457 456 393 50 100 852 546 296 M16576 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 100/279 Gene Ontology BP GO:0007178 1.05683305848386e-08 7.02990815263694e-08 445 450.818181818182 444 9.60757330509696e-10 87 2.26246723483542 2.51512467150806 1 15.0225174370349 356 1022 304 87 513 444 553 201 380 655 444 297 M16142 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. 38/115 Gene Ontology BP GO:0002690 5.00465912643831e-08 1.96818485411937e-07 270 699 446 4.54969021844231e-09 110 2.07086198939395 2.22529992073682 1 12.8907912108585 267 802 446 1482 1082 178 110 161 2292 471 398 298 M10729 GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 203/467 Gene Ontology BP GO:0071496 1.45965457203303e-08 8.61140556283272e-08 345 663.727272727273 447 1.32695871065231e-09 194 1.88884995246097 2.14495568879295 1 12.3872302239883 344 1273 441 969 630 228 447 252 1768 755 194 299 M16139 GO_RENAL_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_FILTRATION.html A renal system process in which fluid circulating through the body is filtered through a barrier system. 3/13 Gene Ontology BP GO:0097205 2.09484116872225e-06 4.20871810747616e-06 470 988.454545454545 448 2.09484314348666e-07 147 2.04082891044534 2.04082891044534 1 10.1841054324282 468 448 4517 635 2259 294 147 405 425 893 382 300 M10947 GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 137/324 Gene Ontology BP GO:0031668 1.14312770067227e-08 7.3818385455095e-08 340 628.818181818182 449 1.03920700601091e-09 124 1.9202273968124 2.14678653320436 1 12.712270098035 339 1013 416 1294 538 169 449 175 1630 770 124 301 M14620 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 37/87 Gene Ontology BP GO:0071230 2.22446118802932e-09 3.09454965761073e-08 650 552.909090909091 449 2.02223744570774e-10 148 2.54791240204753 3.10717896311267 1 17.7606565236741 649 148 263 297 188 1331 971 449 526 354 906 302 M16415 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 23/54 Gene Ontology BP GO:0044246 4.88040689084924e-08 1.93177571988176e-07 230 542.636363636364 450 4.43673363555871e-09 183 2.39047106532035 2.50103482434581 1 14.8983017130681 229 381 345 751 1074 329 183 827 818 450 582 303 M16425 GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. 59/153 Gene Ontology BP GO:0001936 7.52168858117603e-08 2.62383171167545e-07 365 583.545454545455 450 6.83789894394433e-09 292 2.22736757809109 2.30935284002242 1 13.6068358403385 363 645 353 528 1244 292 442 657 1008 437 450 304 M14909 GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. 19/58 Gene Ontology BP GO:0031952 8.38059759452446e-09 6.2020801523756e-08 535 653.090909090909 452 7.61872511495379e-10 85 1.89716435816817 2.18218442152943 1 12.6927723625027 532 1680 1221 452 414 299 85 100 541 1592 268 305 M10398 GO_CELL_PART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PART_MORPHOGENESIS.html The process in which the anatomical structures of a cell part are generated and organized. 338/988 Gene Ontology BP GO:0032990 4.98684869732054e-09 4.71210768370877e-08 455 536.454545454545 453 4.53349882602226e-10 30 1.73133282524371 1.96029545659566 1 11.7750601210354 453 30 411 361 234 625 953 758 1040 340 696 306 M11734 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 31/88 Gene Ontology BP GO:0001837 1.54264962140868e-08 8.82555423854249e-08 425 543.090909090909 453 1.40240875656892e-09 153 2.11057253172639 2.15526830220149 1 13.8204046048668 424 1601 638 231 655 365 153 485 453 682 287 307 M14192 GO_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REMODELING.html The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. 74/161 Gene Ontology BP GO:0048771 3.02960807588728e-12 7.32628661267951e-11 480 414.909090909091 453 2.75418915990133e-13 104 2.12151447611423 2.30132116865946 1 19.9592337839707 479 502 178 190 817 453 340 173 807 104 521 308 M15118 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. 42/84 Gene Ontology BP GO:0045669 7.65562475828965e-09 5.91432042474856e-08 310 520.909090909091 456 6.95965889539085e-10 182 2.19921013578914 2.11258620703115 1 14.7556968970739 308 661 456 182 375 767 546 948 390 408 689 309 M16228 GO_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 461/1233 Gene Ontology BP GO:0060284 2.84364451653541e-21 3.22025402201802e-19 295 413.818181818182 456 2.58513137866855e-22 30 1.862571003009 2.14492771438114 1 31.9718997119265 292 456 40 250 477 684 602 172 1077 30 472 310 M15511 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT.html Any process that modulates the frequency, rate or extent of the movement of a cellular component. 450/1139 Gene Ontology BP GO:0051270 2.74366612369599e-28 8.49256120821367e-26 15 506.272727272727 457 2.49424193063271e-29 14 1.89524720694931 2.1014857264442 1 44.1068448823836 129 606 15 359 838 457 438 505 1577 14 631 311 M15911 GO_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 177/435 Gene Ontology BP GO:0001525 4.40418727086483e-19 3.46587144044499e-17 50 549.272727272727 458 4.00380660987711e-20 50 2.19183853147815 2.25306637065444 1 33.4897940116771 50 474 56 458 1289 404 319 915 1357 91 629 312 M14257 GO_HEAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_DEVELOPMENT.html The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. 399/1144 Gene Ontology BP GO:0060322 1.40504095973443e-16 6.65673997555812e-15 675 481.272727272727 459 1.27730996339494e-17 52 2.01225901197543 2.35420188831553 1 26.4806929564594 675 459 89 52 106 902 1036 482 1023 122 348 313 M10293 GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of adipocyte differentiation. 70/139 Gene Ontology BP GO:0045598 1.37679481759642e-08 8.32189868277674e-08 305 473.272727272727 460 1.25163166019329e-09 99 1.98074857342559 2.21211698731863 1 13.0172156906214 305 506 406 99 603 460 473 249 1234 537 334 314 M11956 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. 190/470 Gene Ontology BP GO:0032970 7.51791836201455e-09 5.86332115310401e-08 460 564.454545454545 460 6.83447126155003e-10 186 1.90103101892261 2.15727207326708 1 12.7616881425542 460 288 296 186 611 911 564 427 1231 333 902 315 M10966 GO_CELLULAR_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 10/27 Gene Ontology BP GO:0071285 3.93576965512011e-09 4.21425504795384e-08 465 1076.27272727273 461 3.5779724201465e-10 21 2.9899865369035 2.9899865369035 1 20.4699525292571 461 2335 1461 1074 3428 214 141 21 150 2466 88 316 M12726 GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 19/52 Gene Ontology BP GO:0051491 1.54166174141286e-07 4.62404819500526e-07 120 505.090909090909 461 1.40151077222331e-08 118 2.4190582334242 2.54460768863579 1 14.225270913119 118 828 623 141 1472 287 163 461 225 689 549 317 M14574 GO_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT.html The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 87/290 Gene Ontology BP GO:0045165 3.26766285224607e-13 9.36528310060402e-12 465 627.818181818182 462 2.97060259295142e-14 47 2.31211963675049 2.56711417854106 1 23.6698259668254 462 314 151 47 83 1761 1403 974 501 257 953 318 M10110 GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS.html The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 507/1359 Gene Ontology BP GO:0048646 1.30206721492809e-11 2.90648946101496e-10 230 701.818181818182 463 1.30206721493572e-12 14 1.87411532482538 2.08660888375358 1 16.5905368297109 228 14 3534 17 147 463 638 748 1292 31 608 319 M13989 GO_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSPORT.html The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 97/297 Gene Ontology BP GO:0006816 6.26596106341455e-09 5.30891555062659e-08 380 679.454545454545 463 5.69632825569185e-10 305 1.73216813110401 1.83260705419741 1 11.697467012976 380 771 528 1015 305 421 463 510 2301 388 392 320 M12865 GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 126/317 Gene Ontology BP GO:0090092 4.07129534901068e-09 4.27670233155127e-08 465 514.363636363636 464 3.70117759685907e-10 67 1.97254914642931 2.05328786154092 1 13.4927073046331 464 67 309 269 166 811 884 663 1233 304 488 321 M15904 GO_PATTERN_SPECIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_SPECIFICATION_PROCESS.html Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. 210/609 Gene Ontology BP GO:0007389 2.91025927323153e-09 3.65029676110884e-08 385 496.818181818182 464 2.64569025189214e-10 96 1.9712108860269 2.14555589589174 1 13.609408080191 383 616 286 464 96 615 585 366 1102 422 530 322 M15988 GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 40/141 Gene Ontology BP GO:0030801 1.45059718286897e-09 2.27537929731779e-08 445 694.090909090909 464 1.31872471256858e-10 21 2.14206528487856 2.19773051600633 1 15.197167203979 445 1139 464 813 21 479 286 1086 2123 435 344 323 M14953 GO_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 17/46 Gene Ontology BP GO:0010226 2.27161670896486e-07 6.31002192826494e-07 550 570.727272727273 466 2.06510631229215e-08 74 3.47580936814047 4.12966412408303 1 20.0038972195591 549 690 521 179 1602 442 466 452 74 995 308 324 M13518 GO_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_GROWTH.html The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. 39/100 Gene Ontology BP GO:0035265 1.9066229753044e-07 5.44096525773715e-07 220 562.545454545455 468 1.73329376412845e-08 219 2.1655422875009 2.18673574891499 1 12.5924437418336 219 663 592 468 1553 249 305 933 480 410 316 325 M15871 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. 43/118 Gene Ontology BP GO:1900076 4.66768150778604e-09 4.5728211272053e-08 470 700.909090909091 469 4.24334683426303e-10 171 1.89154705535265 2.18387123238659 1 12.8875821048694 469 524 1107 890 206 267 337 367 1377 1995 171 326 M13784 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell migration. 47/93 Gene Ontology BP GO:0014910 2.55690499616794e-08 1.22011406959998e-07 15 536.454545454545 470 2.32445911444096e-09 11 2.06457539239964 2.13537997887186 1 13.2496407773113 11 1297 524 470 1763 24 75 61 956 661 59 327 M16856 GO_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 13/37 Gene Ontology BP GO:0010453 2.93250202863148e-09 3.65029676110884e-08 565 403.545454545455 470 2.66591093867307e-10 15 2.09602938232973 1.97289102778284 1 14.471165637249 561 564 504 129 576 255 137 15 951 470 277 328 M10496 GO_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. 361/931 Gene Ontology BP GO:0043408 6.89824055610927e-09 5.5896214488683e-08 470 600.545454545455 471 6.27112779794468e-10 314 1.76206241386686 1.99645170233804 1 11.8627451916536 466 460 314 471 345 531 636 644 1827 337 575 329 M16155 GO_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 212/571 Gene Ontology BP GO:0097305 5.01575115176897e-25 1.10895869512682e-22 475 510.181818181818 471 4.55977377433541e-26 21 2.39755695033686 2.63222883012951 1 48.8622192289448 472 471 21 267 360 1064 738 183 1330 128 578 330 M10785 GO_LOOP_OF_HENLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOOP_OF_HENLE_DEVELOPMENT.html The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. 8/16 Gene Ontology BP GO:0072070 2.42703167572897e-09 3.30460647226088e-08 1175 931.636363636364 473 2.42703167837968e-10 13 2.83335163786668 3.17133568691959 1 19.675343235833 1172 435 3633 260 473 1491 1039 13 82 1515 135 331 M11112 GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE.html A process that modulates the size of a cellular component. 206/480 Gene Ontology BP GO:0032535 1.64896905333436e-08 9.15809008927206e-08 400 562.545454545455 473 1.49906278699446e-09 281 1.82240326982676 2.08778977061291 1 11.9062479191982 348 473 369 634 683 398 397 716 1336 553 281 332 M12273 GO_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_PAIN.html The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. 38/149 Gene Ontology BP GO:0019233 1.98695322781866e-08 1.03077361304604e-07 435 674.090909090909 473 1.80632113251276e-09 259 2.34008413221881 2.40219372834109 1 15.1768346103346 435 1947 447 579 748 473 439 360 888 840 259 333 M14468 GO_RESPONSE_TO_VITAMIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. 20/35 Gene Ontology BP GO:0033197 6.51642508879134e-11 1.32700709154641e-09 550 510.636363636364 474 5.92402280816761e-12 95 2.78088711351423 3.31604938305192 1 22.9152668600379 548 171 211 95 750 735 474 1177 206 322 928 334 M12268 GO_HYALURONAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 21/45 Gene Ontology BP GO:0030212 3.12307215452304e-08 1.40371965280257e-07 680 609.909090909091 477 2.8391565444159e-09 107 1.95328668426908 1.93039994187741 1 12.4250483535081 470 679 680 1394 920 296 177 107 1224 477 285 335 M15173 GO_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. 74/169 Gene Ontology BP GO:0001952 1.10165116857563e-08 7.2143390348331e-08 260 559.727272727273 477 1.00150106735651e-09 228 2.318207205557 2.52268400123553 1 15.3684221596384 260 503 302 228 1374 816 477 474 513 347 863 336 M11036 GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 36/90 Gene Ontology BP GO:0051965 1.02527283811251e-07 3.33590875077534e-07 85 580.909090909091 479 9.32066259903295e-09 60 1.89975254724096 1.87504342748115 1 11.4215673972507 82 1223 560 985 1344 101 60 479 684 407 465 337 M16725 GO_NEGATIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a lower concentration of a chemical. 30/67 Gene Ontology BP GO:0050919 1.68195287835346e-07 4.94158896168119e-07 2420 767.909090909091 481 1.52904818812983e-08 28 2.28559057140909 2.32704627235265 1 13.3792178031288 86 2420 876 883 2419 53 28 147 481 985 69 338 M14229 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. 4/32 Gene Ontology BP GO:1902547 1.56222330439053e-08 8.86167057924368e-08 485 1148.36363636364 483 1.56222331537297e-09 13 2.24592018698111 2.24592018698111 1 14.7029875342952 483 991 4209 879 2692 469 316 55 13 2087 438 339 M14946 GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 84/207 Gene Ontology BP GO:0051896 2.92569494995733e-09 3.65029676110884e-08 125 489.181818181818 483 2.65972268531644e-10 99 1.82056783766126 2.05797293697705 1 12.5693556104641 122 778 483 105 99 260 550 589 1380 815 200 340 M15978 GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. 6/24 Gene Ontology BP GO:0010640 2.75061348529896e-07 7.39068195152955e-07 485 1197.63636363636 484 2.75061382576337e-08 82 1.99510307395049 1.99510307395049 1 11.3550260665972 484 2115 4490 1038 1830 339 82 193 411 1740 452 341 M12560 GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. 145/340 Gene Ontology BP GO:0051056 1.35725157869552e-09 2.16553920270904e-08 490 763 486 1.23386507230259e-10 17 2.04385044064374 2.37533212088288 1 14.5411359587521 486 484 326 58 17 1973 1348 1008 717 365 1611 342 M13680 GO_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTION.html Self-propelled movement of a cell or organism from one location to another. 550/1674 Gene Ontology BP GO:0040011 2.38166453484283e-18 1.53584283823268e-16 235 754.272727272727 486 2.38166453484284e-19 8 2.00441611725801 2.13086751915422 1 29.4231547797883 231 12 4114 107 383 560 644 486 1248 8 504 343 M13433 GO_MESONEPHRIC_TUBULE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHRIC_TUBULE_MORPHOGENESIS.html The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. 24/83 Gene Ontology BP GO:0072171 3.50743984948679e-09 3.98870630704176e-08 2425 1377.81818181818 489 3.18858168643514e-10 48 2.26079428835065 2.58504366916242 1 15.5279122643211 2422 166 448 48 125 3787 2255 3366 60 489 1990 344 M16970 GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of stem cell differentiation. 84/226 Gene Ontology BP GO:2000736 1.68650625556153e-07 4.94658783611635e-07 255 629.090909090909 490 1.53318762258915e-08 217 2.14770769247922 2.43618762570441 1 12.571213971147 251 1441 427 239 1505 652 490 217 626 613 459 345 M15544 GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH.html Any process that modulates the extent of cell growth. 66/153 Gene Ontology BP GO:0061387 4.00443699458298e-08 1.67651947392685e-07 200 615 491 3.64039733406518e-09 142 2.28562335442973 2.54227511584738 1 14.3754354555283 199 2212 491 574 1004 177 300 287 665 714 142 346 M12450 GO_CELL_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. 131/292 Gene Ontology BP GO:0034330 3.3779133321555e-16 1.52268462147553e-14 355 490.363636363636 492 3.07083030195955e-17 63 2.2405949283493 2.46761287248226 1 28.738129987156 354 63 94 454 1071 508 816 668 704 170 492 347 M16461 GO_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIOR.html The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 235/825 Gene Ontology BP GO:0007610 7.5907130201927e-14 2.38132976707802e-12 315 433.454545454545 492 6.90064820017541e-15 45 1.90217443085742 2.11258251158592 1 20.5231707356668 311 45 137 593 430 492 590 524 1007 134 505 348 M12259 GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. 17/55 Gene Ontology BP GO:0043534 4.54286792361352e-07 1.12194339198604e-06 365 883.272727272727 493 4.1298807833534e-08 221 2.55025584455353 2.66856163883859 1 14.0854904646943 365 2056 808 493 2479 280 268 221 682 1810 254 349 M10653 GO_CELLULAR_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 260/821 Gene Ontology BP GO:0071396 1.13508996565103e-17 6.42710086648506e-16 675 607.727272727273 494 1.03189996877367e-18 76 2.1171437700809 2.31670438317377 1 29.8561641474751 405 1110 76 428 672 709 674 494 1410 290 417 350 M11055 GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. 13/34 Gene Ontology BP GO:0002042 5.53674591974496e-07 1.32784665833553e-06 225 919.636363636364 494 5.03340664834526e-08 97 2.14353952464896 2.14353952464896 1 11.6935234214885 224 2012 1264 494 1861 202 97 465 989 2298 210 351 M16337 GO_AXONAL_FASCICULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_FASCICULATION.html The collection of axons into a bundle of rods, known as a fascicle. 14/43 Gene Ontology BP GO:0007413 1.85385137033878e-09 2.70421771353233e-08 700 695.727272727273 494 1.68531942900085e-10 41 2.14201796285839 2.38814067906143 1 15.0477295783367 494 1325 1152 699 41 475 228 313 697 1912 317 352 M13576 GO_SKIN_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. 45/111 Gene Ontology BP GO:0098773 4.636289540015e-08 1.8702252245256e-07 500 631.272727272727 497 4.21480876156398e-09 319 2.30561042537407 2.45646991550196 1 14.3995159826181 319 796 363 915 1047 486 500 497 1156 405 460 353 M16360 GO_CELLULAR_GLUCURONIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCURONIDATION.html The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. 3/23 Gene Ontology BP GO:0052695 3.55403845492281e-09 3.98870630704176e-08 640 877.454545454545 497 3.55403846060684e-10 1 4.39353459956901 4.39353459956901 1 30.176305990651 637 597 4552 19 158 1115 497 38 1 1762 276 354 M12414 GO_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/110 Gene Ontology BP GO:0051952 1.66615123386786e-07 4.91538842913147e-07 545 701.090909090909 499 1.5146830545931e-08 147 2.65897883484345 3.02431466029897 1 15.5706284752624 541 151 435 147 1497 1284 1211 251 245 499 1451 355 M16445 GO_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cell proliferation. 806/2183 Gene Ontology BP GO:0042127 2.85525568272579e-11 6.02588733404356e-10 475 994.181818181818 499 2.85525568276247e-12 33 1.78724421079759 2.05144670534738 1 15.29617934446 471 450 4568 412 300 1008 710 499 1829 33 656 356 M10162 GO_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCRETION.html The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. 23/63 Gene Ontology BP GO:0007588 1.61339244880377e-09 2.44803305222088e-08 1700 1171.54545454545 502 1.46672040907906e-10 157 2.3726565255476 2.81730971220811 1 16.7631703310752 1700 378 258 453 1585 2596 1408 3402 502 448 157 357 M16818 GO_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_CIRCULATION.html Any process that modulates the frequency, rate or extent of blood circulation. 141/435 Gene Ontology BP GO:1903522 1.72001389878506e-12 4.41216824975636e-11 225 644 502 1.56364899889672e-13 115 1.98393097923798 2.03149205737793 1 19.0704258972081 223 762 167 502 1062 369 453 1349 1433 115 649 358 M16019 GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. 4/17 Gene Ontology BP GO:0007171 2.53723716700678e-09 3.40132659424763e-08 795 792.636363636364 504 2.53723716990368e-10 32 3.11403096627789 2.91003793518452 1 21.5882194746437 794 245 4494 504 84 568 240 987 32 659 112 359 M14048 GO_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. 280/697 Gene Ontology BP GO:0001944 9.97163850810696e-28 2.89364484957129e-25 50 550.363636363636 505 9.06512591646083e-29 16 2.1463855226878 2.24925330476318 1 48.8906545513226 48 273 16 550 1142 505 420 1015 1301 45 739 360 M10338 GO_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT.html Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 36/89 Gene Ontology BP GO:0046324 1.94510213885353e-08 1.02046431985276e-07 885 547.636363636364 508 1.768274687319e-09 146 1.99315440711223 2.38636897606585 1 12.934866213614 884 146 459 508 738 929 557 464 609 406 324 361 M16341 GO_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 42/169 Gene Ontology BP GO:0030814 9.67672048649926e-09 6.70582286848001e-08 110 766.545454545455 509 8.79701866278397e-10 49 2.18216461841618 2.24490716148631 1 14.5308376305529 227 1524 509 1443 470 107 109 1055 2218 721 49 362 M16783 GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 62/155 Gene Ontology BP GO:0010717 7.34870533628822e-08 2.57899008891808e-07 275 558.909090909091 514 6.68064143796232e-09 244 2.14833200767388 2.35784900268459 1 13.138942200942 273 922 502 244 1234 525 387 320 519 708 514 363 M10257 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 144/369 Gene Ontology BP GO:0090287 1.03911367613915e-08 6.96878588290404e-08 315 526.454545454545 515 9.44648800951949e-10 62 1.92404208266751 2.02311463727747 1 12.7821875294461 333 62 315 597 505 638 672 515 1252 311 591 364 M11163 GO_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of muscle contraction. 89/232 Gene Ontology BP GO:0006937 1.07186490536082e-08 7.10952679370044e-08 355 888.818181818182 515 9.74422645984608e-10 315 2.09664313622917 2.10798326506253 1 13.9119457440155 352 1719 375 1199 515 487 522 1935 1857 315 501 365 M11353 GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cell junction assembly. 66/135 Gene Ontology BP GO:1901888 3.2014429545074e-07 8.38843094682724e-07 205 660.636363636364 516 2.91040310943809e-08 204 2.21559525316849 2.19931238320204 1 12.4968381724981 204 640 379 232 2182 609 318 691 516 514 982 366 M13564 GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 105/252 Gene Ontology BP GO:0010952 6.71924501491418e-09 5.5021965792322e-08 820 667.363636363636 516 6.10840457766919e-10 80 1.75561223791098 2.14417202921621 1 11.8304777766375 818 80 497 346 333 1609 1063 357 1200 516 522 367 M14612 GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. 44/143 Gene Ontology BP GO:0002688 3.81228323705879e-08 1.61500283482336e-07 505 779.818181818182 516 3.46571209374561e-09 239 1.96834447976492 2.21641679105438 1 12.4095730051638 505 660 455 1479 993 516 444 239 2202 374 711 368 M12438 GO_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 86/203 Gene Ontology BP GO:0043279 7.81863916753419e-09 5.99607899848217e-08 200 602.181818181818 517 7.10785381392823e-10 33 2.1273488095988 2.34268257541823 1 14.2617658461157 196 1660 517 686 1171 88 144 33 1514 573 42 369 M16907 GO_CORPUS_CALLOSUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORPUS_CALLOSUM_DEVELOPMENT.html The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. 18/36 Gene Ontology BP GO:0022038 8.60461306331771e-08 2.91614733233461e-07 430 1045 517 7.82237581805482e-09 123 1.93688132929132 1.93688132929132 1 11.7497980366671 428 2823 1807 865 1284 330 123 517 494 2422 402 370 M10703 GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS.html The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 73/306 Gene Ontology BP GO:0050954 2.94694996781638e-10 5.47307548022857e-09 550 640.909090909091 518 2.67904542564648e-11 204 2.40722368617641 2.89794190356221 1 18.4611440213678 547 1443 231 472 1124 518 996 353 778 384 204 371 M14928 GO_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. 43/111 Gene Ontology BP GO:0030510 1.86959699772535e-09 2.70421771353233e-08 250 531.363636363636 518 1.69963363574015e-10 44 1.73066466415207 1.85999229221283 1 12.157962362895 250 799 881 568 44 680 454 145 1093 518 413 372 M11868 GO_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH.html Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. 363/998 Gene Ontology BP GO:0040008 1.18275796304574e-09 1.93364268395118e-08 520 580.636363636364 519 1.07523451243782e-10 137 1.95299889746172 2.18971797633895 1 13.9839411238443 519 999 252 463 543 410 796 697 1308 263 137 373 M16538 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. 43/230 Gene Ontology BP GO:0007187 5.04029677889618e-09 4.7372667903674e-08 235 792.090909090909 519 4.58208799131249e-10 206 2.06172045592551 1.94217723763059 1 14.0176511667181 235 1371 691 1944 238 343 229 1078 1859 519 206 374 M12783 GO_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIOGENESIS.html The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. 101/263 Gene Ontology BP GO:0042063 1.14918879690468e-08 7.40651016364725e-08 520 579.818181818182 520 1.04471709355233e-09 267 1.92058533062011 2.31226405273385 1 12.7120562655232 520 310 412 287 539 1143 960 998 562 267 380 375 M12531 GO_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 26/57 Gene Ontology BP GO:0034333 3.56581691268326e-09 3.98870630704176e-08 450 565.454545454545 521 3.24165174405711e-10 128 2.12876907078686 2.56430484724283 1 14.621117677795 446 170 880 521 128 883 784 406 624 944 434 376 M10429 GO_SINGLE_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BEHAVIOR.html The specific behavior of a single organism in response to external or internal stimuli. 185/632 Gene Ontology BP GO:0044708 9.45303446600114e-09 6.64805736677504e-08 345 520.636363636364 524 8.59366773329023e-10 54 1.79315398604787 1.99311184985618 1 11.9467049342287 342 54 338 669 459 524 660 569 1046 266 800 377 M12814 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. 14/35 Gene Ontology BP GO:0045987 3.15083665095047e-09 3.80972254436537e-08 410 591.181818181818 525 2.86439695951191e-10 16 2.24405447368061 2.39419567142878 1 15.4544710676516 406 697 793 525 1479 200 167 16 1101 1020 99 378 M16028 GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of embryonic development. 18/48 Gene Ontology BP GO:0040019 1.11237440867609e-08 7.24740874297928e-08 595 485 529 1.01124946754594e-09 238 2.60112084881126 2.76096130167468 1 17.2391862855367 592 1068 580 278 529 340 274 558 238 617 261 379 M12853 GO_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_GROWTH.html Any process that modulates the frequency, rate or extent of growth of an organ of an organism. 40/110 Gene Ontology BP GO:0046620 8.26267040542293e-09 6.16777792481972e-08 185 615.090909090909 530 7.51151857859593e-10 181 2.83066846899995 3.23366139532494 1 18.9446094067582 830 352 530 183 408 1478 707 422 181 955 720 380 M15892 GO_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. 73/178 Gene Ontology BP GO:0007498 8.78085185850434e-09 6.38020268842499e-08 165 661.545454545455 530 7.98259263050122e-10 161 1.81886657503944 1.87760385722029 1 12.1481673591254 161 1215 843 543 431 211 363 530 1397 1130 453 381 M11625 GO_REGULATION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSITIVE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 16/34 Gene Ontology BP GO:0050926 2.33075211688517e-07 6.44677452298209e-07 165 595.454545454545 531 2.1188657852843e-08 30 2.52923680948249 2.52923680948249 1 14.5343431142702 165 1319 715 531 1610 161 30 269 594 911 245 382 M15140 GO_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHRONIC_INFLAMMATORY_RESPONSE.html Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. 12/23 Gene Ontology BP GO:0002544 1.94335664837726e-07 5.52541636155273e-07 860 647.272727272727 533 1.76668801822046e-08 245 2.0702583453829 2.2969079115953 1 12.0255211348786 857 708 829 519 1560 400 245 317 533 777 375 383 M16285 GO_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. 40/129 Gene Ontology BP GO:0001823 5.13589157989125e-09 4.81736254655254e-08 1440 996.272727272727 533 4.66899235625543e-10 55 2.15158471898505 2.29566600083307 1 14.6140961109689 1437 139 462 55 241 2317 1189 2842 167 533 1577 384 M13099 GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 9/22 Gene Ontology BP GO:0009068 4.17656540578072e-09 4.30928737311998e-08 2310 1290.54545454545 534 4.17656541363038e-10 32 1.51573737432381 -1.85898278684383 -1 10.3633675556137 2306 432 4012 424 203 1107 2499 32 534 2346 301 385 M13864 GO_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MIGRATION.html The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. 63/181 Gene Ontology BP GO:0001764 8.0665920760148e-09 6.09517268535486e-08 650 515 535 7.33326555053821e-10 3 2.13433207096828 2.48387439032955 1 14.2944780978093 646 329 443 280 1001 745 535 105 851 727 3 386 M11704 GO_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 43/108 Gene Ontology BP GO:0045446 4.84001933363704e-07 1.18274788242509e-06 100 751.545454545455 537 4.4000185440417e-08 96 2.4776160542342 2.44683926394558 1 13.6315728802998 172 1989 426 553 1846 99 96 537 1045 1399 105 387 M12233 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 27/43 Gene Ontology BP GO:0010656 1.12447677986507e-08 7.28165368049306e-08 390 634.272727272727 538 1.02225162328415e-09 6 2.01189378196975 2.14839275070045 1 13.3302020557926 389 1052 675 538 1774 222 142 92 1453 634 6 388 M14836 GO_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 65/167 Gene Ontology BP GO:0033273 3.09633659111796e-14 1.03426552464465e-12 525 645 541 2.8148514464709e-15 129 2.29689754343289 2.65684533945479 1 25.5541908217542 521 326 129 331 1015 1152 912 541 1027 215 926 389 M15722 GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. 120/298 Gene Ontology BP GO:0090257 8.14356993743777e-09 6.11821929118504e-08 2210 1008.63636363636 541 7.40324542507473e-10 402 1.99406939048661 2.00126599856056 1 13.3520487891709 498 2209 541 1446 402 520 504 1634 2206 686 449 390 M12854 GO_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 43/117 Gene Ontology BP GO:0051963 1.63111473718634e-07 4.84224151199243e-07 145 581.090909090909 542 1.48283168919979e-08 134 1.95826728627546 1.93892822443232 1 11.4791905243892 143 935 463 981 1489 171 134 654 589 291 542 391 M15229 GO_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. 472/1348 Gene Ontology BP GO:0030030 6.70688485131219e-09 5.50177850965416e-08 610 599.272727272727 543 6.09716806523517e-10 254 1.67896425145221 1.94980685754372 1 11.3140243116819 606 257 382 310 332 774 1129 543 1307 254 698 392 M15768 GO_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. 31/92 Gene Ontology BP GO:0048709 2.14071869697811e-09 3.01192633638466e-08 770 565.545454545455 543 1.9461079082374e-10 54 2.13354705920666 2.57100414350161 1 14.8955292775861 767 154 641 207 54 1480 1290 549 213 543 323 393 M11440 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. 166/433 Gene Ontology BP GO:0030111 1.02493341873068e-07 3.33590875077534e-07 370 624.181818181818 544 9.31757696800144e-09 231 2.03228278509188 2.29577143904907 1 12.21835699651 369 1204 422 435 1343 732 571 250 765 544 231 394 M10800 GO_RESPONSE_TO_DIETARY_EXCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DIETARY_EXCESS.html The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. 9/30 Gene Ontology BP GO:0002021 3.01079101775985e-08 1.38040760677831e-07 545 836 545 3.01079105855173e-09 77 2.66717767412493 2.66717767412493 1 16.9841859104804 545 717 3639 991 945 334 210 261 345 1132 77 395 M12042 GO_NEGATIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COAGULATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. 24/67 Gene Ontology BP GO:0050819 2.66930088251695e-13 7.84402784653556e-12 145 611.545454545455 547 2.42663716592479e-14 145 2.55934731996284 2.60469527689893 1 26.3836545328587 145 676 147 901 1752 314 328 602 1088 227 547 396 M14175 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. 32/51 Gene Ontology BP GO:0014911 5.49701231235907e-08 2.10679839510667e-07 85 673.181818181818 547 4.99728404519066e-09 18 2.24273306065006 2.24273306065006 1 13.8991286487899 18 1789 547 718 2064 56 83 83 1018 908 121 397 M14469 GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 49/134 Gene Ontology BP GO:0051897 2.93139734709053e-08 1.35391351781977e-07 180 592.909090909091 550 2.66490671468184e-09 31 2.01080243921647 2.17579501943515 1 12.8201968040587 178 932 550 576 891 91 513 371 1660 729 31 398 M15116 GO_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 44/111 Gene Ontology BP GO:0034332 1.13304317228817e-08 7.32690731049298e-08 475 625.090909090909 551 1.03003925283961e-09 133 2.11058261027897 2.31789602086652 1 13.9788130217338 475 133 551 329 535 1083 1263 547 586 681 693 399 M16939 GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of cell proliferation. 406/1017 Gene Ontology BP GO:0008285 1.40430215582055e-14 5.01551916113447e-13 380 602.727272727273 552 1.27663832347323e-15 120 1.79750192177026 2.10748168449428 1 20.5226037022464 377 891 120 552 586 743 744 378 1563 221 455 400 M10363 GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. 126/300 Gene Ontology BP GO:0045665 1.1894316101617e-08 7.57548829352642e-08 325 584.727272727273 553 1.08130146962943e-09 270 2.028318473643 2.32620427815201 1 13.4066793786704 322 1015 355 270 553 759 903 459 794 561 441 401 M12230 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WOUND_HEALING.html Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 31/82 Gene Ontology BP GO:0061045 1.56124876633522e-12 4.07240338319912e-11 380 594.090909090909 554 1.41931706030575e-13 164 2.60135036834486 2.55020344196094 1 25.0893709766853 378 668 164 554 1308 472 327 980 769 209 706 402 M15176 GO_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. 358/940 Gene Ontology BP GO:0030155 1.41341700252836e-23 2.43055375657007e-21 30 616.181818181818 555 1.28492454775305e-24 26 1.98148937169811 2.23926938361785 1 37.9165984244809 320 29 26 256 831 1366 1045 555 1265 41 1044 403 M13473 GO_FACE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FACE_DEVELOPMENT.html The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. 36/90 Gene Ontology BP GO:0060324 2.45907029578788e-08 1.19429533298568e-07 425 546.090909090909 556 2.23551847570396e-09 399 2.20654348162551 2.56941754974501 1 14.1797622170142 425 667 490 404 837 556 566 642 399 611 410 404 M11764 GO_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. 61/145 Gene Ontology BP GO:0019722 8.04834284324643e-07 1.83448482185533e-06 220 840.545454545455 559 7.31667798873045e-08 216 2.37412411999687 2.34418437660312 1 12.6420785441539 216 1890 445 797 1968 355 467 1204 822 559 523 405 M12776 GO_EMBRYONIC_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_MORPHOGENESIS.html Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 152/440 Gene Ontology BP GO:0048562 2.22938722089168e-11 4.85964547727702e-10 560 880.818181818182 559 2.0267156553766e-12 198 1.9956752901641 2.3300866138529 1 17.2530968035553 559 482 198 475 394 1696 1188 1273 1712 316 1396 406 M15366 GO_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. 76/209 Gene Ontology BP GO:0010001 4.15725138347978e-09 4.30928737311998e-08 895 696.272727272727 563 3.77931944666869e-10 102 1.88408619271813 2.37233696066516 1 12.8818343648771 895 102 563 225 175 1834 1580 785 523 378 599 407 M12232 GO_FATTY_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. 28/61 Gene Ontology BP GO:0035337 9.97984539058073e-09 6.85740984125671e-08 875 1073.54545454545 566 9.07258675986568e-10 47 1.36383745953021 -1.1228110389947 -1 9.06938040641786 873 370 2183 1938 478 47 236 2459 566 2572 87 408 M15611 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 20/48 Gene Ontology BP GO:0050654 1.1384095002231e-07 3.63024403127462e-07 185 681.181818181818 566 1.03491778102828e-08 48 1.89016860395443 2.03020590544963 1 11.2995168739616 184 555 792 1833 1377 125 48 583 1329 566 101 409 M15496 GO_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION.html The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. 21/98 Gene Ontology BP GO:0001708 4.97161109830153e-09 4.71210768370877e-08 570 630.818181818182 568 4.51964646321497e-10 232 2.73900244856153 3.33388783779033 1 18.6283759186375 568 393 609 290 232 1048 810 976 517 1068 428 410 M10640 GO_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 225/596 Gene Ontology BP GO:1901652 6.47900606634768e-12 1.48187316088928e-10 570 947.363636363636 570 5.89000551487887e-13 48 1.90970461990534 1.98372885138015 1 17.424206941971 570 48 189 376 562 1854 1285 2209 1526 308 1494 411 M14412 GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). 38/201 Gene Ontology BP GO:0007188 5.22626890433776e-09 4.85311330456804e-08 200 742.727272727273 570 4.75115356068471e-10 200 2.07988835703983 1.92040228558684 1 14.1209170744545 200 1374 756 1550 247 326 262 1122 1552 570 211 412 M12631 GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of adherens junction organization. 52/107 Gene Ontology BP GO:1903391 3.81190445540022e-07 9.69790267749218e-07 250 690.636363636364 571 3.46536828716628e-08 240 2.49708733944087 2.54040327632776 1 13.9385417895456 247 928 381 240 1985 777 422 571 460 596 990 413 M13942 GO_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_MORPHOGENESIS.html The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. 293/783 Gene Ontology BP GO:0048598 1.13247844704601e-15 4.78008857239513e-14 190 538.363636363636 572 1.02952586095092e-16 101 1.95765687738027 2.09861219420917 1 24.2062953706752 187 271 101 263 572 674 659 713 1516 212 754 414 M12408 GO_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_DEVELOPMENT.html The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. 97/277 Gene Ontology BP GO:0060348 3.0428311274646e-08 1.3850847965508e-07 450 570.272727272727 573 2.76621015413651e-09 225 1.97970393006431 2.27838639137527 1 12.6037569657548 447 312 323 573 904 740 1040 289 817 225 603 415 M15225 GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of MAP kinase activity. 128/335 Gene Ontology BP GO:0043406 1.43244171456301e-07 4.33454996891125e-07 370 759.636363636364 574 1.30221982530065e-08 351 1.78832673485169 2.07875691229398 1 10.5628654423397 351 1117 574 535 1454 370 366 820 1612 600 557 416 M10442 GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS.html The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 22/50 Gene Ontology BP GO:0050951 4.54099245331888e-08 1.84299195461185e-07 580 879.636363636364 577 4.12817504277177e-09 354 2.4040676088692 2.29687350655632 1 15.028639228804 930 1388 553 577 1041 1157 354 2132 441 527 576 417 M11609 GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 448/1229 Gene Ontology BP GO:1901701 2.25129159129658e-18 1.50810290381526e-16 580 752 578 2.04662871936053e-19 66 1.83904684061865 2.10082904828026 1 27.0091850321814 578 457 66 377 254 1532 1080 886 1910 144 988 418 M13300 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 491/1400 Gene Ontology BP GO:0014070 1.2025401018836e-27 3.28434923120326e-25 570 623.909090909091 578 1.09321827443962e-28 17 2.00561363217902 2.16913670690448 1 45.5817309939202 567 455 17 411 578 810 792 939 1601 36 657 419 M12632 GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. 361/914 Gene Ontology BP GO:0007167 1.32187132186863e-13 3.9853561996338e-12 580 628.090909090909 579 1.20170120169882e-14 143 1.80458486425933 2.01964317062608 1 19.0956085261239 579 266 143 495 465 961 1026 916 1072 203 783 420 M15453 GO_REGULATION_OF_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_SPECIFICATION.html Any process that mediates the adoption of a specific fate by a cell. 10/24 Gene Ontology BP GO:0042659 4.79251948090931e-08 1.90597891726138e-07 355 677.545454545455 579 4.35683598664584e-09 117 1.66324506695695 1.58934755279878 1 10.3749740413797 353 713 788 429 1066 151 117 579 2539 595 123 421 M10452 GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. 47/108 Gene Ontology BP GO:0050848 1.44616512466486e-09 2.27537929731779e-08 585 603.090909090909 581 1.31469556874136e-10 20 1.70581913522495 2.00607955170551 1 12.1021608033245 581 131 845 871 20 582 545 529 1455 660 415 422 M13356 GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. 15/46 Gene Ontology BP GO:0086019 4.99415375654202e-07 1.21148672370034e-06 390 796.636363636364 582 4.54014080931835e-08 310 2.18937697243077 2.18829343452464 1 12.024523088523 388 1471 582 749 1840 493 386 1520 405 310 619 423 M10532 GO_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASODILATION.html Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. 20/71 Gene Ontology BP GO:0042312 2.54173976645478e-08 1.21690920089996e-07 585 843.181818181818 583 2.31067254165492e-09 189 2.39215857087011 2.00733938232048 1 15.3544785029912 583 189 460 917 851 512 267 2826 1534 431 705 424 M12296 GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. 8/21 Gene Ontology BP GO:0048714 1.92287787412298e-06 3.91747343990917e-06 410 1018.54545454545 583 1.9228795379817e-07 18 3.89246547462362 3.89246547462362 1 19.5366362112902 407 583 3886 197 2389 688 598 359 18 1523 556 425 M12811 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. 3/15 Gene Ontology BP GO:0048934 1.64258446638487e-07 4.86399411493216e-07 585 1199.45454545455 585 1.64258458779865e-08 153 3.27803121667969 3.27803121667969 1 19.2096074786369 585 1348 3963 1178 2676 484 435 153 417 1757 198 426 M16262 GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of cation channel activity. 48/127 Gene Ontology BP GO:2001257 9.61547572639991e-09 6.67334137483928e-08 515 712.636363636364 585 8.74134160765996e-10 344 1.67465974191531 1.90288877487592 1 11.1546863926619 511 344 944 799 468 578 456 617 1506 1031 585 427 M11927 GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY.html Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 120/367 Gene Ontology BP GO:0050803 8.57721426411413e-09 6.28138893190566e-08 905 711.636363636364 586 7.79746754323127e-10 423 1.77491778700441 1.81422513830117 1 11.8658030483241 455 904 586 847 423 553 547 1105 975 530 903 428 M14140 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 3/15 Gene Ontology BP GO:0048935 1.59978350509943e-07 4.76140693216451e-07 590 1220.72727272727 586 1.59978362026826e-08 149 3.27803121667969 3.27803121667969 1 19.2377775047145 586 1349 4191 1179 2677 485 436 149 418 1759 199 429 M15026 GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 515/1522 Gene Ontology BP GO:0071495 3.40972702292751e-09 3.9381498924011e-08 505 882.363636363636 586 3.40972702815931e-10 16 1.95389225327875 2.09062433594546 1 13.4300512368834 501 16 4335 43 148 619 729 1277 1374 78 586 430 M10752 GO_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 29/52 Gene Ontology BP GO:0034405 1.85292171891003e-08 9.93431355762042e-08 375 578.545454545455 587 1.68447430410548e-09 160 1.81776878901463 2.02553033663502 1 11.816350201254 371 160 515 687 717 656 298 202 1241 930 587 431 M11993 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 15/33 Gene Ontology BP GO:0044253 5.27933940455824e-09 4.88286311859839e-08 755 589.090909090909 588 4.79939947020642e-10 164 2.5451886395724 2.7690533684551 1 17.2736942975539 754 410 424 164 249 1171 918 704 306 588 792 432 M12003 GO_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MOTILITY.html Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. 429/1223 Gene Ontology BP GO:0048870 1.24102087406968e-30 7.20257489788191e-28 255 440.363636363636 588 1.1282007946088e-31 7 1.99439014782534 2.11918294065393 1 50.2492174338644 252 26 7 113 649 659 641 611 1283 15 588 433 M13227 GO_LOCALIZATION_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_OF_CELL.html Any process in which a cell is transported to, and/or maintained in, a specific location. 429/1223 Gene Ontology BP GO:0051674 1.24102087406968e-30 7.20257489788191e-28 255 457.363636363636 589 1.1282007946088e-31 8 1.99439014782534 2.11918294065393 1 50.2492174338644 253 27 8 114 650 660 642 788 1284 16 589 434 M13010 GO_LEUKOCYTE_TETHERING_OR_ROLLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_TETHERING_OR_ROLLING.html Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). 10/17 Gene Ontology BP GO:0050901 3.66108194434647e-07 9.40177182942515e-07 760 734.818181818182 591 3.32825686690688e-08 37 2.37501434148021 2.94324358266004 1 13.2868322555142 759 430 748 563 2289 446 37 616 591 1334 270 435 M14170 GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL.html The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. 10/17 Gene Ontology BP GO:0061756 3.66108194434647e-07 9.40177182942515e-07 760 737.363636363636 592 3.32825686690688e-08 38 2.37501434148021 2.94324358266004 1 13.2868322555142 760 431 749 564 2290 447 38 631 592 1338 271 436 M13216 GO_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. 39/90 Gene Ontology BP GO:0048546 7.44877541871479e-09 5.86001158819183e-08 250 674.090909090909 593 6.77161403994083e-10 246 2.02977988149629 2.20420072589389 1 13.6264458134182 246 1784 830 663 364 535 285 394 986 735 593 437 M16187 GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. 15/33 Gene Ontology BP GO:0010714 5.27933940455824e-09 4.88286311859839e-08 755 591.636363636364 593 4.79939947020642e-10 165 2.5451886395724 2.7690533684551 1 17.2736942975539 755 411 425 165 250 1172 919 718 307 593 793 438 M16925 GO_DIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 112/346 Gene Ontology BP GO:0072511 6.63230219898947e-09 5.4988891267693e-08 595 839.818181818182 593 6.02936565362161e-10 325 1.69953452709289 1.79860481011891 1 11.4530009971536 421 1511 538 1234 325 617 593 593 2425 404 577 439 M16663 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY.html Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. 6/14 Gene Ontology BP GO:2000095 6.47007857020192e-07 1.52412860484259e-06 415 1132.36363636364 595 6.47008045398893e-08 175 2.15998855787318 2.15998855787318 1 11.6632083890108 411 595 4600 859 1932 232 275 476 1160 1741 175 440 M11839 GO_AMEBOIDAL_TYPE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMEBOIDAL_TYPE_CELL_MIGRATION.html Cell migration that is accomplished by extension and retraction of a pseudopodium. 90/270 Gene Ontology BP GO:0001667 2.9819974625001e-08 1.37166995396063e-07 585 786.818181818182 596 2.71090682083608e-09 301 2.02911061287793 2.17681737943073 1 12.9262651433361 301 1355 390 581 895 596 520 1085 1723 583 626 441 M11957 GO_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING.html The series of events that restore integrity to a damaged tissue, following an injury. 278/666 Gene Ontology BP GO:0042060 4.23189255156824e-17 2.13572577357949e-15 215 541.454545454545 596 3.84717504688021e-18 84 1.99906910531627 2.25469189380789 1 27.2232841030356 212 465 84 596 857 632 812 275 1236 108 679 442 M11375 GO_CARDIAC_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MYOFIBRIL_ASSEMBLY.html The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. 15/41 Gene Ontology BP GO:0055003 4.54984798265798e-10 8.21982263948677e-09 600 746.181818181818 597 4.13622543963538e-11 236 3.29968999635856 3.50215115960005 1 24.7645072917347 597 558 236 366 661 1180 1226 1140 267 309 1668 443 M12465 GO_EAR_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_DEVELOPMENT.html The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 112/339 Gene Ontology BP GO:0043583 8.78957402660358e-12 2.0004898139961e-10 215 591 597 7.99052184239881e-13 190 2.09832157309068 2.43721073934813 1 18.8913083776838 211 628 190 343 514 639 597 907 1504 246 722 444 M11882 GO_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 288/754 Gene Ontology BP GO:0010035 2.4950632079545e-18 1.58692855815517e-16 645 604.818181818182 598 2.26823927995863e-19 68 2.03056586736926 2.39594277847324 1 29.7802258485266 642 609 68 78 316 1124 930 538 1548 202 598 445 M14584 GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. 189/605 Gene Ontology BP GO:0051346 3.64419474193626e-09 4.0381852474487e-08 1090 704.181818181818 598 3.31290431633882e-10 138 1.85584377349741 2.18049566271956 1 12.7373492385435 1090 287 298 509 138 1314 1124 598 1243 445 700 446 M10709 GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 128/326 Gene Ontology BP GO:0060828 4.05112590094869e-07 1.02058478340232e-06 455 717.090909090909 599 3.68284240630151e-08 247 2.05199679411418 2.41116284335258 1 11.4118504477846 452 903 440 477 1770 1204 807 247 634 599 355 447 M15728 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. 11/23 Gene Ontology BP GO:0016338 8.52234880206028e-07 1.92738750550248e-06 420 755.727272727273 600 7.74759282131383e-08 222 2.73602726234234 -3.01542041910206 -1 14.5147026788049 418 222 485 1085 1987 591 1166 600 298 706 755 448 M16582 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 642/1720 Gene Ontology BP GO:0010648 3.49644129745072e-09 3.98870630704176e-08 525 955.363636363636 601 3.49644130295201e-10 155 1.68137632296181 1.97425577354627 1 11.548270465233 523 601 4586 632 155 658 678 330 1681 182 483 449 M11800 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 664/1619 Gene Ontology BP GO:0051130 3.57377088892822e-09 3.98870630704176e-08 805 971.272727272727 602 3.57377089467554e-10 94 1.7691114563668 2.11160739956681 1 12.1508655261452 804 602 3807 94 159 1520 1049 207 1635 331 476 450 M16952 GO_POSITIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSSIFICATION.html Any process that activates or increases the frequency, rate or extent of bone formation. 57/117 Gene Ontology BP GO:0045778 1.81079308612539e-09 2.66905152345403e-08 440 676.454545454545 604 1.64617553419621e-10 38 2.16202862299318 2.11371782613461 1 15.1997137096894 436 790 434 209 38 1267 650 1716 604 393 904 451 M10248 GO_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION.html The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 213/1652 Gene Ontology BP GO:0007600 2.92760643265749e-16 1.33263496733615e-14 400 711.181818181818 605 2.66146039332498e-17 93 2.10080716902203 2.44707566867597 1 27.0581039504978 400 2118 93 708 935 605 963 303 1117 130 451 452 M11334 GO_TISSUE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. 109/311 Gene Ontology BP GO:0001894 1.20405741136585e-07 3.80043409991274e-07 400 760.727272727273 606 1.09459770660343e-08 378 2.20563144063833 2.53286887060001 1 13.1446307417904 396 1437 378 737 1392 523 603 723 1099 474 606 453 M12221 GO_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_EXTRAVASATION.html The migration of a leukocyte from the blood vessels into the surrounding tissue. 20/37 Gene Ontology BP GO:0045123 3.70741978951982e-07 9.48927788464197e-07 530 829.181818181818 607 3.37038219480995e-08 187 2.38821078838181 2.71668362531359 1 13.3517392335339 529 1547 705 569 1741 349 187 607 1249 1352 286 454 M12132 GO_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGING.html A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). 170/435 Gene Ontology BP GO:0007568 1.1031937758833e-12 2.92693068652922e-11 610 679.636363636364 609 1.00290343262168e-13 161 2.15736009363778 2.57334733337544 1 21.0944442866951 609 620 161 570 581 1616 1020 254 1149 286 610 455 M13165 GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. 49/157 Gene Ontology BP GO:0055007 3.95563489743192e-09 4.22207191466125e-08 340 648.272727272727 609 3.59603173140384e-10 162 2.60793644477326 2.82939162344399 1 17.8524247658069 338 1521 403 950 162 317 392 843 910 609 686 456 M12269 GO_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION.html The movement of a leukocyte within or between different tissues and organs of the body. 130/380 Gene Ontology BP GO:0050900 1.00376894159218e-17 5.75370271087961e-16 350 603.181818181818 612 9.12517219629248e-19 64 2.29777226933997 2.45256058066716 1 32.5059294763466 349 64 75 84 618 1058 612 1161 1341 98 1175 457 M14602 GO_DETECTION_OF_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_STIMULUS.html The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. 150/1291 Gene Ontology BP GO:0051606 2.07032907958932e-08 1.05829926808989e-07 615 958.090909090909 613 1.88211736279303e-09 107 2.03539440294348 2.31115080055368 1 13.1791165747424 613 3170 408 2228 765 401 723 344 1400 380 107 458 M15320 GO_RESPONSE_TO_MINERALOCORTICOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MINERALOCORTICOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. 20/50 Gene Ontology BP GO:0051385 5.27325317188996e-07 1.27056120794422e-06 255 741.636363636364 614 4.79386766895815e-08 109 2.38892954226926 2.57667240141533 1 13.0746561488336 255 1236 743 614 1863 254 166 455 1108 1355 109 459 M10465 GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 27/64 Gene Ontology BP GO:0071364 3.67242195594643e-08 1.57743530572826e-07 1770 793.636363636364 615 3.33856547022685e-09 102 2.344095630811 2.76196014390806 1 14.8007656507307 1770 363 327 200 1132 1922 888 615 102 298 1113 460 M13821 GO_DISTAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISTAL_TUBULE_DEVELOPMENT.html The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. 6/19 Gene Ontology BP GO:0072017 3.77090667867534e-09 4.11960463743285e-08 1890 1335.63636363636 615 3.77090668507422e-10 26 1.94651329707799 2.65078892813342 1 13.3439837818562 1888 244 4138 185 174 2657 1895 26 615 2541 329 461 M12951 GO_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. 25/52 Gene Ontology BP GO:0045445 1.34310647709839e-07 4.12709687171927e-07 420 668.909090909091 616 1.22100596281404e-08 292 2.33348232087599 2.51571302276718 1 13.8289976077405 417 1056 616 348 1432 406 292 715 1066 695 315 462 M16598 GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 18/39 Gene Ontology BP GO:0010922 5.96123990952703e-08 2.22615357609157e-07 585 748.272727272727 617 5.41930915550548e-09 338 2.0611316389217 2.38678969497592 1 12.7278822799838 582 834 1037 617 1149 600 338 586 771 1112 605 463 M14191 GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 103/238 Gene Ontology BP GO:0031345 5.81494573992486e-09 5.0871514261604e-08 505 594 618 5.28631432299516e-10 280 1.92469367787642 2.19335632801007 1 13.0307151446947 503 631 526 372 280 841 698 554 870 641 618 464 M13731 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of phagocytosis. 33/79 Gene Ontology BP GO:0050766 3.46197739138349e-08 1.51071062295052e-07 620 802.818181818182 620 3.14725222351096e-09 394 1.98371610946594 1.9668932457164 1 12.5598705244419 394 807 612 1019 958 616 595 559 1658 620 993 465 M16105 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. 88/216 Gene Ontology BP GO:1903035 3.00052363690876e-09 3.7150483323113e-08 290 680.727272727273 620 2.72774876454645e-10 273 2.07394109659437 2.22179861830411 1 14.3039651793258 286 1213 273 755 449 620 396 796 1461 359 880 466 M15023 GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of glia cell differentiation. 37/97 Gene Ontology BP GO:0045685 1.91209431435566e-07 5.44989084077049e-07 405 835.818181818182 622 1.73826770958387e-08 340 2.33265809961142 2.68171753245853 1 13.5626665765104 518 1302 851 405 1555 622 403 960 340 1849 389 467 M10499 GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the rate of skeletal muscle tissue development. 14/40 Gene Ontology BP GO:0048643 1.00250950310817e-09 1.6803796472676e-08 970 832 624 9.1137227596818e-11 8 2.3126246575579 2.4629963726548 1 16.6898306019053 563 968 967 624 2699 408 431 8 964 1410 110 468 M12376 GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. 12/52 Gene Ontology BP GO:0061098 4.43126773820225e-08 1.81272036198e-07 470 880 624 4.02842529768856e-09 79 2.97731531404863 2.97731531404863 1 18.6320828494304 467 2328 1217 1173 1583 624 242 79 144 1600 223 469 M15883 GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 9/22 Gene Ontology BP GO:0043649 5.171597842682e-09 4.82163228585794e-08 785 927.545454545455 628 5.17159785471743e-10 87 1.44206880053675 -1.21717920010715 -1 9.79437322253611 782 231 4472 628 272 225 652 1116 87 1144 594 470 M16537 GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. 102/257 Gene Ontology BP GO:0014074 2.23889845989314e-10 4.20858524262504e-09 595 618.090909090909 630 2.03536223647363e-11 228 2.10823073520972 2.15965929845401 1 16.3914316734777 593 630 228 520 363 706 635 995 1034 247 848 471 M13136 GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. 13/29 Gene Ontology BP GO:2001273 3.28540507784698e-07 8.56492744325857e-07 425 839.636363636364 631 2.98673233498026e-08 132 1.76922010306215 1.90801766478151 1 9.96425360792272 631 421 1577 732 1711 366 227 424 710 2305 132 472 M11568 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of epithelial cell proliferation. 98/243 Gene Ontology BP GO:0050679 2.7088118957242e-11 5.74292859901712e-10 695 660.636363636364 632 2.46255626887051e-12 69 2.15785747727528 2.28059071645756 1 18.5099222466013 692 632 204 69 397 1289 1339 573 840 149 1083 473 M12614 GO_SULFUR_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 23/44 Gene Ontology BP GO:0044273 3.63651637120702e-08 1.56772010320466e-07 495 776.363636363636 632 3.30592402847024e-09 289 2.19343843866934 2.34552043140465 1 13.8549696127912 491 1387 801 1834 972 511 303 361 632 959 289 474 M15050 GO_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 75/182 Gene Ontology BP GO:0032526 2.47758765340938e-14 8.52106627761462e-13 285 581.272727272727 632 2.25235241219037e-15 125 2.35788678741814 2.62067218453708 1 26.4168837328188 284 321 125 196 632 1109 908 834 693 235 1057 475 M15963 GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. 5/24 Gene Ontology BP GO:0036152 3.32606083929396e-08 1.46795631909143e-07 640 1115.63636363636 636 3.32606088907602e-09 69 1.76954962055726 -1.76954962055726 -1 11.2243585902131 636 989 4488 1473 1816 119 69 75 96 2292 219 476 M10339 GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 160/477 Gene Ontology BP GO:0045861 4.66835497371379e-09 4.5728211272053e-08 825 637.545454545455 638 4.24395907601813e-10 207 1.9615243840287 2.17674072579264 1 13.364355114828 822 1010 358 638 207 695 819 273 1359 502 330 477 M11397 GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 24/67 Gene Ontology BP GO:0009187 1.49608140550371e-06 3.16604647481938e-06 80 1160.36363636364 638 1.3600749299049e-07 79 1.63642028313365 1.63642028313365 1 8.35383372587451 79 2089 1113 2771 2537 100 111 430 2647 638 249 478 M13002 GO_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. 149/391 Gene Ontology BP GO:0046883 3.67269627343435e-07 9.42229979496284e-07 440 1018.09090909091 639 3.33881535141557e-08 276 1.66274114086048 1.79057702954184 1 9.30061342159926 440 1656 639 1807 1736 276 529 882 2159 506 569 479 M11052 GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. 15/43 Gene Ontology BP GO:0045939 6.93734465510535e-08 2.46631632723232e-07 1600 810.090909090909 640 6.30667715805757e-09 28 2.66058093916225 2.75028036130442 1 16.3197101354047 1596 409 640 126 1211 2247 976 504 28 803 371 480 M13192 GO_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE.html Any process that modulates the frequency or rate of heart contraction. 58/161 Gene Ontology BP GO:0002027 3.32462653061344e-09 3.8784525079493e-08 295 903.090909090909 640 3.02238775967054e-10 278 2.45363756257892 2.52745148598708 1 16.8801528587552 295 1891 278 417 1970 640 538 1866 767 351 921 481 M13373 GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. 24/58 Gene Ontology BP GO:0030514 6.6029852804824e-09 5.49420441886734e-08 185 614.272727272727 640 6.00271390936393e-10 27 1.91436837540061 1.96187423944819 1 12.901403592033 183 1384 912 757 1554 229 68 27 833 640 170 482 M15288 GO_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_BEHAVIOR.html The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. 87/330 Gene Ontology BP GO:0007626 4.53630461336601e-09 4.52060867120778e-08 640 687.727272727273 640 4.12391329338154e-10 92 1.76667633624924 2.02977679038353 1 12.0449855601312 640 92 602 675 201 1067 1022 483 1383 515 885 483 M16833 GO_CARDIAC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. 37/93 Gene Ontology BP GO:0055006 5.65192197619393e-09 5.04881982447536e-08 410 737.090909090909 643 5.13811090064912e-10 268 2.80743425113868 3.03728323352501 1 19.0156763560378 489 1841 407 643 268 551 410 1016 829 787 867 484 M16847 GO_INNER_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. 59/188 Gene Ontology BP GO:0042472 3.02539819804275e-08 1.3822254686434e-07 335 657.272727272727 644 2.75036203604314e-09 320 2.24816459995489 2.58978638023691 1 14.3147809509618 335 644 320 485 1296 707 666 460 959 505 853 485 M12263 GO_PROXIMAL_DISTAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROXIMAL_DISTAL_PATTERN_FORMATION.html The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). 18/48 Gene Ontology BP GO:0009954 1.39398884038387e-07 4.24690957080203e-07 375 1110.90909090909 645 1.26726266246488e-08 131 2.83297527727949 2.83297527727949 1 16.7564769031057 375 2236 1103 2160 2369 374 485 131 645 1926 416 486 M11264 GO_CAMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 8/17 Gene Ontology BP GO:0006171 8.26398020556481e-07 1.87810377358969e-06 370 1373.72727272727 646 8.26398327876802e-08 209 1.42268379179958 1.42268379179958 1 7.5622342454463 368 438 3719 2110 1996 407 209 1285 3329 646 604 487 M16623 GO_COPULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPULATION.html The act of sexual union between male and female, involving the transfer of sperm. 7/20 Gene Ontology BP GO:0007620 3.4291298478989e-06 6.53321702248445e-06 540 1173.63636363636 648 3.42913513942958e-07 432 2.48045441622854 2.71910936824526 1 11.9381904016229 538 727 4594 1129 2375 648 432 596 461 511 899 488 M12949 GO_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 69/175 Gene Ontology BP GO:0051591 7.52646867811757e-09 5.86332115310401e-08 1365 994.818181818182 651 6.84224427624231e-10 108 2.22378930634405 2.33566551749731 1 14.9283759210813 1362 108 297 433 370 1987 1370 1597 651 439 2329 489 M16217 GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS.html The process in which the branching structure of the salivary gland is generated and organized. 9/33 Gene Ontology BP GO:0060445 1.48824521156263e-05 2.49879725639113e-05 135 1184.90909090909 653 1.48825517858872e-06 134 2.16227226730851 2.16227226730851 1 9.23743739978276 134 1409 4529 809 2910 413 335 653 538 753 551 490 M16602 GO_NEURAL_CREST_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. 40/108 Gene Ontology BP GO:0014033 1.74001248846639e-08 9.50456233405817e-08 320 649.272727272727 653 1.58182954748037e-09 181 2.1244617300974 2.57572137692026 1 13.8478729742913 316 800 311 181 1237 724 404 941 1161 653 414 491 M10259 GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING.html The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. 301/794 Gene Ontology BP GO:0009792 1.12541849000009e-09 1.85558929239851e-08 655 771.363636363636 654 1.02310771870527e-10 14 1.85409132331667 2.02020063897891 1 13.3065367097146 654 462 251 522 14 1601 1176 791 1517 332 1165 492 M10349 GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION.html A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. 46/78 Gene Ontology BP GO:0061572 7.14913052329309e-09 5.74280502070066e-08 655 1071.72727272727 655 6.49920958774992e-10 351 1.59121470564467 1.91968550162872 1 10.695202793747 655 2310 1795 1367 351 623 588 411 1396 1917 376 493 M11136 GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of smooth muscle contraction. 34/84 Gene Ontology BP GO:0006940 8.70298216783462e-08 2.94089855933451e-07 140 714.818181818182 669 7.9118022837418e-09 60 2.2376158942928 2.15391831587373 1 13.566534764588 137 1454 676 1476 1288 60 101 484 1434 669 84 494 M11155 GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. 46/125 Gene Ontology BP GO:0044259 9.65119878840183e-14 2.96758383937415e-12 175 581.636363636364 670 8.7738170803657e-15 140 2.52467495264163 2.72620346574626 1 27.0155240102 171 652 140 670 974 778 461 808 728 190 826 495 M11376 GO_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_CONTRACTION.html Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. 110/333 Gene Ontology BP GO:0008016 1.00727344886581e-09 1.68229159103739e-08 320 820.727272727273 670 9.15703135751805e-11 248 1.99277585872673 2.10420739331672 1 14.3806210125534 317 1352 248 633 1463 614 670 1333 1386 256 756 496 M13423 GO_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. 796/2245 Gene Ontology BP GO:0045595 3.15344228972153e-17 1.66379915354285e-15 575 1051.09090909091 670 3.15344228972154e-18 3 1.81798043524303 2.02198842426541 1 24.9402284887878 575 3 4073 358 406 1677 1130 670 1591 11 1068 497 M16274 GO_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 27/68 Gene Ontology BP GO:0051489 5.99956037548418e-07 1.42412877420108e-06 665 731.181818181818 670 5.45414728328059e-08 148 2.19402542672866 2.37605485147143 1 11.9070200761893 663 1049 670 148 1881 813 731 292 303 636 857 498 M14080 GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/58 Gene Ontology BP GO:0010828 2.14565292935443e-07 5.99053911665222e-07 570 730.272727272727 672 1.95059376238118e-08 183 1.97653189857576 2.27075979340202 1 11.4166910020159 566 183 879 1059 1591 714 540 507 694 628 672 499 M15524 GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. 39/105 Gene Ontology BP GO:0007422 7.52878894511197e-08 2.6243368672789e-07 160 781.272727272727 672 6.84435382069131e-09 109 1.68410778898987 1.86500975694121 1 10.2879682829057 160 1299 1027 1811 1245 109 176 672 1254 602 239 500 M11648 GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 7/13 Gene Ontology BP GO:0032352 1.24996650062202e-07 3.89764571013301e-07 1215 1016.90909090909 673 1.24996657093076e-08 30 2.0342313441898 -1.99767170788925 -1 12.1024456461802 1211 239 3781 215 1440 532 1206 673 30 1309 550 501 M11775 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of hair follicle development. 7/18 Gene Ontology BP GO:0051797 4.74195589543858e-07 1.16306926690551e-06 680 1043.81818181818 676 4.74195690731543e-08 50 3.03464686769106 3.39459184143578 1 16.7168215114936 665 982 3802 676 2703 399 50 676 391 796 342 502 M15529 GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 20/44 Gene Ontology BP GO:0002089 6.05241471277727e-09 5.17520469823662e-08 300 718.818181818182 679 5.50219520857095e-10 296 1.7028022218238 1.81414464952083 1 11.5166675201295 702 827 1016 298 296 679 502 1547 510 565 965 503 M15681 GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. 40/181 Gene Ontology BP GO:0007156 3.97076328530672e-08 1.66542492625827e-07 680 823.272727272727 679 3.60978486997703e-09 136 2.36601108625552 2.29848206939269 1 14.8873674007003 679 136 331 592 1056 963 1198 2366 243 652 840 504 M11712 GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 28/69 Gene Ontology BP GO:0070849 6.20611157676536e-08 2.29236086323958e-07 1765 864 681 5.64191977439754e-09 104 2.344095630811 2.76196014390806 1 14.447544193562 1763 362 356 210 1162 2070 1184 681 104 334 1278 505 M12706 GO_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_REMODELING.html The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. 34/78 Gene Ontology BP GO:0046849 8.09059838157829e-08 2.7702542983531e-07 545 906.727272727273 682 7.35508970828518e-09 443 1.95985781952937 2.14930062414204 1 11.92973233388 542 1994 946 973 1270 653 443 495 1305 671 682 506 M14668 GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. 134/297 Gene Ontology BP GO:2001234 5.84633524626625e-09 5.0927832173385e-08 1060 687.909090909091 683 5.31485023800222e-10 57 1.78755086552519 2.13705483764767 1 12.1014225485128 1057 304 683 620 283 1344 803 208 1402 806 57 507 M12844 GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that activates or increases the activity of a phosphoprotein phosphatase. 13/27 Gene Ontology BP GO:0032516 4.90495704280972e-08 1.93983948464783e-07 510 679.818181818182 685 4.45905195651547e-09 223 1.89442407750352 2.2189739811603 1 11.803571664654 506 223 1021 881 1076 383 296 685 1098 897 412 508 M16165 GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. 20/59 Gene Ontology BP GO:0046622 2.53521041399572e-09 3.40132659424763e-08 1095 753.363636363636 685 2.30473674265201e-10 66 3.03698776210546 3.37939155061072 1 21.0541125134661 1092 685 656 203 66 1663 1186 358 283 979 1116 509 M10093 GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 54/171 Gene Ontology BP GO:0008277 1.28975837585675e-09 2.07209278169651e-08 690 784.545454545455 687 1.17250761510262e-10 16 1.76500715725207 2.06010703486311 1 12.5886695638964 687 339 744 1583 16 549 408 836 2025 396 1047 510 M10576 GO_HEART_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 16/39 Gene Ontology BP GO:0061384 2.69382033419792e-08 1.27107802964237e-07 480 878.636363636364 687 2.44892760652979e-09 276 2.87032944163071 3.34611175910739 1 18.373305245536 478 1244 986 1064 865 687 586 276 490 2689 300 511 M10367 GO_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_SECRETION.html The controlled release of acid by a cell or a tissue. 28/113 Gene Ontology BP GO:0046717 3.87472251625239e-07 9.81469538623015e-07 690 795.545454545455 688 3.52247563516657e-08 163 2.57034160377534 2.70096991750022 1 14.3350367152266 688 163 478 319 1759 1327 1140 742 280 542 1313 512 M13878 GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 269/752 Gene Ontology BP GO:1901699 7.76028404796624e-10 1.34444025502639e-08 680 806.636363636364 688 7.05480368245783e-11 42 1.80320742773847 1.98703779370833 1 13.1755888144757 677 42 244 688 151 1582 1089 1248 1856 323 973 513 M10516 GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. 28/70 Gene Ontology BP GO:0055024 4.95333309971628e-08 1.95231965891194e-07 460 780.727272727273 689 4.50303019203756e-09 354 2.69699334854562 2.99733202571197 1 16.7971605434803 459 1227 689 354 1080 972 565 958 613 1099 572 514 M11147 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 12/37 Gene Ontology BP GO:0055012 1.22298248928815e-06 2.65465530517292e-06 830 926.545454545455 690 1.11180288104184e-07 118 3.21628275891407 3.43647362932055 1 16.6473645839383 826 2560 850 690 2066 669 143 522 118 1164 584 515 M13111 GO_OPTIC_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPTIC_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. 11/26 Gene Ontology BP GO:0021554 1.59396413357341e-07 4.74930230104745e-07 695 946.181818181818 691 1.44905840823706e-08 22 2.00732142938088 2.30571743679023 1 11.7824244298955 691 2398 1591 971 1644 389 22 246 269 2020 167 516 M13913 GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 18/47 Gene Ontology BP GO:0051954 2.57153226232619e-08 1.22332216126849e-07 695 628.727272727273 694 2.33775662944025e-09 41 2.60496425424852 3.26017460929244 1 16.714888480802 694 186 630 41 897 1271 1172 62 53 817 1093 517 M16700 GO_RESPONSE_TO_MONOAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MONOAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. 16/70 Gene Ontology BP GO:0071867 3.3059595083731e-06 6.34017761147307e-06 415 1265.36363636364 695 3.00542225116202e-07 268 1.24305815584823 1.34827385922246 1 5.99775022786524 504 412 2161 1249 2636 268 695 412 2581 2703 298 518 M15408 GO_OUTFLOW_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. 36/92 Gene Ontology BP GO:0003151 7.43268027576508e-08 2.59863964761877e-07 460 785.181818181818 696 6.7569822971614e-09 201 1.88925672479822 2.08857077631792 1 11.5486877233015 456 531 402 758 1240 696 746 1465 1678 201 464 519 M12265 GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. 24/72 Gene Ontology BP GO:1903792 3.61395805472059e-07 9.30762314381591e-07 950 868.454545454545 698 3.28541695308054e-08 531 2.44391152691902 2.67351083654517 1 13.682187970061 569 948 619 1105 1731 946 611 531 698 639 1156 520 M14034 GO_SYNAPTIC_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_SIGNALING.html Cell-cell signaling to or from a synapse. 168/577 Gene Ontology BP GO:0099536 2.75421789372559e-08 1.28945787512304e-07 530 847.818181818182 701 2.50383448018739e-09 275 1.77673152804202 1.90791543180402 1 11.3627774385717 528 1276 605 1046 875 510 701 1615 1332 275 563 521 M10215 GO_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 463/1225 Gene Ontology BP GO:1901698 1.50481786766655e-16 7.0574437975513e-15 90 709.727272727273 704 1.36801624333322e-17 24 1.85200899638575 2.06179536881703 1 24.3282114511764 704 24 90 167 266 1556 1168 1074 1692 89 977 522 M12159 GO_MOTOR_NEURON_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_NEURON_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. 19/55 Gene Ontology BP GO:0008045 3.17220381304485e-08 1.41794606093639e-07 285 860 706 2.88382168980473e-09 169 2.06664492638402 2.08115460851006 1 13.1377300452658 281 2555 1072 1187 927 251 169 706 683 1220 409 523 M13657 GO_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE.html The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. 240/732 Gene Ontology BP GO:0006954 9.96131234998468e-17 4.81774721260196e-15 430 783.454545454545 706 9.05573849998604e-18 87 2.03576931991252 2.1986517923748 1 27.0554312532528 429 1201 87 706 1065 970 654 662 1802 93 949 524 M12727 GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 36/61 Gene Ontology BP GO:0010660 3.61439684003879e-07 9.30762314381591e-07 940 824.909090909091 707 3.28581584895541e-08 176 1.839678624508 2.02677488519591 1 10.2994025538905 707 937 865 657 1732 613 418 582 1450 937 176 525 M14994 GO_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_ACTIVATION.html Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 19/56 Gene Ontology BP GO:0010543 2.03286372753263e-06 4.10373316823217e-06 405 903.636363636364 709 1.84805964178184e-07 403 2.52149685373455 2.76007617572757 1 12.6084035649523 403 832 429 948 2536 604 632 984 1171 692 709 526 M15680 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 56/201 Gene Ontology BP GO:0070588 1.51696262444418e-08 8.7711799069668e-08 630 769.272727272727 709 1.37905694082188e-09 302 1.81378834371981 1.90682474677489 1 11.8815277935117 630 334 561 709 645 1028 1023 961 1311 302 958 527 M16014 GO_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIOGENESIS.html Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. 54/139 Gene Ontology BP GO:0014013 3.88352454142593e-08 1.63474201684865e-07 490 744.363636363636 709 3.53047691816309e-09 346 2.10282814453307 2.52050849344128 1 13.2471367422906 488 1037 709 352 1000 1042 587 873 346 1158 596 528 M14978 GO_REGULATION_OF_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUTAMATE_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of glutamate. 9/26 Gene Ontology BP GO:0014048 3.65445681623356e-07 9.39515116155725e-07 710 1194.27272727273 710 3.65445741721115e-08 99 3.62187360347257 3.62187360347257 1 20.2633176948152 710 582 4327 425 2059 1332 693 213 99 1664 1033 529 M10347 GO_METENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. 58/189 Gene Ontology BP GO:0022037 3.66901438030599e-09 4.04637381657024e-08 1825 1400 711 3.33546762402266e-10 143 2.07867868735024 2.51098888258439 1 14.2650509869981 1825 1985 711 641 143 3402 2581 587 555 487 2483 530 M14318 GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. 48/121 Gene Ontology BP GO:0032231 4.68639747443595e-08 1.88063469955109e-07 685 830.636363636364 711 4.2603614311497e-09 102 2.19388145231714 2.13673347536618 1 13.6968120698597 711 1449 893 102 1054 645 331 1113 681 1473 685 531 M12187 GO_DIGESTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 94/259 Gene Ontology BP GO:0055123 2.14889034364945e-10 4.08905650228049e-09 610 665.363636363636 712 1.95353667623577e-11 164 2.19636626755369 2.54705077325985 1 17.102194337392 608 772 225 399 213 1153 894 712 916 164 1263 532 M10067 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. 69/164 Gene Ontology BP GO:0050680 2.45392094406814e-06 4.85451851014416e-06 620 917.636363636364 713 2.23083971020136e-07 553 1.74504181727114 2.161026319659 1 8.60764951698622 620 639 713 873 2269 1361 991 553 559 705 811 533 M13093 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. 14/45 Gene Ontology BP GO:1904037 1.50362073587937e-08 8.7574463447947e-08 2950 1775.18181818182 719 1.36692795105097e-09 175 2.17946526961413 -1.66296114481902 -1 14.2783332752933 2949 208 577 175 638 3795 2897 3027 719 521 4021 534 M15388 GO_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_SECRETION.html Any process that modulates the frequency, rate, or extent of peptide secretion. 126/327 Gene Ontology BP GO:0002791 2.91453369928729e-07 7.75483092595466e-07 305 1014.63636363636 719 2.64957644127391e-08 157 1.67011349069381 1.80418340178411 1 9.47298226977047 303 2254 913 1705 1675 157 281 608 2035 719 511 535 M10691 GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION.html A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. 8/20 Gene Ontology BP GO:0060231 1.29970672000038e-08 8.04605106794902e-08 3810 1624.36363636364 721 1.29970672760195e-09 233 2.71999870954571 -3.49602440119416 -1 17.9124322421533 3806 721 3618 336 623 2830 3308 382 233 645 1366 536 M10621 GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 29/68 Gene Ontology BP GO:0010718 1.97928172875088e-06 4.01420448786341e-06 275 851.818181818182 723 1.79934864496406e-07 271 2.83413653833965 2.9883947853169 1 14.1969181875148 271 1674 469 736 2209 765 700 562 332 929 723 537 M15566 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 22/65 Gene Ontology BP GO:0010596 3.17580126668995e-07 8.32594312887717e-07 330 1104.63636363636 723 2.88709247739234e-08 195 1.72770979445729 1.81760284113948 1 9.75017803842721 328 2048 1675 1182 2669 373 283 195 723 2401 274 538 M16163 GO_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 223/596 Gene Ontology BP GO:0048568 1.93992901623202e-12 4.86869752560284e-11 720 909.818181818182 724 1.76357183293975e-13 85 1.89662670714747 2.0847053908544 1 18.1559355821671 718 281 171 724 85 1743 1301 1315 1721 296 1653 539 M14307 GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. 49/122 Gene Ontology BP GO:0006081 1.0509003520248e-08 7.00133341947155e-08 725 1300.27272727273 725 9.55363960949782e-10 49 1.22007524233029 -1.08007502196921 -1 8.103159957615 725 1780 2287 2263 510 49 516 458 2943 2427 345 540 M13732 GO_CELLULAR_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 16/40 Gene Ontology BP GO:0071361 1.48763777178556e-08 8.70405107804676e-08 860 682.818181818182 726 1.35239798349541e-09 57 2.28972344834546 2.50542874695967 1 15.0063131432007 858 561 753 80 634 1362 726 57 444 1266 770 541 M14345 GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. 12/42 Gene Ontology BP GO:0055083 1.74117082866925e-07 5.05968581911612e-07 730 872 726 1.58288269679338e-08 164 1.76306165007676 2.02805782913124 1 10.3036910775467 726 1960 1241 1506 1518 673 382 164 377 776 269 542 M10326 GO_NEURON_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_RECOGNITION.html The process in which a neuronal cell in a multicellular organism interprets its surroundings. 17/63 Gene Ontology BP GO:0008038 8.28445233893664e-10 1.42461897072899e-08 530 964.636363636364 727 7.53132031096024e-11 5 1.94693618955789 2.13002969297471 1 14.1803135425928 526 1687 1460 1154 5 727 580 711 855 2245 661 543 M14605 GO_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/46 Gene Ontology BP GO:0051955 1.31102098248049e-07 4.04456506422385e-07 770 693.727272727273 730 1.19183732782425e-08 127 3.04238995460368 3.39728277432391 1 18.0549972803204 770 185 593 172 1890 1074 730 127 136 904 1050 544 M12723 GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 114/303 Gene Ontology BP GO:0050730 1.32187524896415e-08 8.1342747262004e-08 560 887.454545454545 732 1.20170477900606e-09 495 1.79165167235338 2.14156745583334 1 11.7909668567372 558 1435 802 1251 589 608 732 546 1824 922 495 545 M14930 GO_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_SYSTEM_PROCESS.html A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. 161/419 Gene Ontology BP GO:0003012 1.61478709781095e-17 8.82053705310144e-16 280 711.363636363636 732 1.46798827073722e-18 78 2.25683394253381 2.50708839455356 1 31.5380780631011 276 1113 78 831 900 550 718 1370 1165 92 732 546 M14969 GO_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of MAP kinase activity. 194/484 Gene Ontology BP GO:0043405 1.23190490388136e-07 3.85426850991991e-07 705 864.181818181818 732 1.11991361169337e-08 530 1.73271549823501 2.03223197562009 1 10.316426269027 622 760 589 530 1403 703 702 1038 1659 732 768 547 M12749 GO_POSITIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 139/394 Gene Ontology BP GO:0043270 1.71885236508535e-09 2.5827286508386e-08 705 858.181818181818 733 1.56259306038935e-10 199 1.86855029860847 2.24534885620389 1 13.161237968532 701 300 259 629 733 1815 1564 919 1201 199 1120 548 M13650 GO_MESODERM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_MORPHOGENESIS.html The process in which the anatomical structures of the mesoderm are generated and organized. 49/111 Gene Ontology BP GO:0048332 1.31929434843105e-08 8.1342747262004e-08 735 888 733 1.19935850576599e-09 242 1.75567018265961 1.74509855527768 1 11.5541705160658 242 1370 1073 733 587 538 617 1227 1080 1568 733 549 M15818 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. 26/61 Gene Ontology BP GO:1901016 1.4249189901185e-07 4.32411690922887e-07 685 1314 733 1.29538098400832e-08 288 1.34702340006336 1.21920548896077 1 7.95758785416789 685 545 1299 2069 1450 288 348 3506 3049 733 482 550 M16957 GO_DETECTION_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CALCIUM_ION.html The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. 6/20 Gene Ontology BP GO:0005513 5.93782201229368e-09 5.11489936977357e-08 235 1142.36363636364 733 5.93782202815966e-10 2 2.00677293855243 2.00677293855243 1 13.5820139879723 234 733 4640 1051 2132 235 2 1445 54 1743 297 551 M11646 GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM.html The process in which the anatomical structures of embryonic epithelia are generated and organized. 86/203 Gene Ontology BP GO:0016331 5.72704279693497e-09 5.06886748050269e-08 735 882 735 5.20640255622147e-10 274 1.78346354129431 1.87274049867141 1 12.077136334948 735 494 672 333 274 1654 1210 1267 893 668 1502 552 M15149 GO_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 13/35 Gene Ontology BP GO:0046058 9.51358870489322e-07 2.12772602874852e-06 200 1035.81818181818 735 8.64872074446592e-08 136 1.67170026799546 1.67170026799546 1 8.80177415114558 197 1405 1135 2223 2006 203 136 735 2622 467 265 553 M15282 GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle development. 68/167 Gene Ontology BP GO:0048634 8.31866653648357e-10 1.42522393833554e-08 815 624.363636363636 736 7.5624241269355e-11 6 2.04564437029444 2.50058079969094 1 14.89889451409 814 641 736 245 6 1065 849 274 1223 925 90 554 M16883 GO_POSITIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIOGENESIS.html Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. 26/67 Gene Ontology BP GO:0014015 1.97514802026663e-07 5.58842916398414e-07 740 831.454545454545 737 1.79558927054033e-08 239 2.14427832650559 2.54911895644881 1 12.445678988291 737 543 949 571 1569 1410 844 736 239 947 601 555 M13991 GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that stops or reduces the activity of an enzyme. 416/1178 Gene Ontology BP GO:0043086 4.79512296356957e-09 4.63828248330281e-08 1450 1083.81818181818 741 4.35920270365548e-10 219 1.73943418052939 2.07963975328085 1 11.841231938871 1450 264 432 518 219 3183 1405 741 1625 716 1369 556 M10535 GO_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COCAINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. 28/70 Gene Ontology BP GO:0042220 3.27817376320587e-09 3.84357595519315e-08 280 698.272727272727 742 2.98015797099147e-10 18 2.37719121319728 2.43674357034629 1 16.3628858920394 280 1734 983 850 1696 124 88 18 742 1100 66 557 M12211 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. 14/40 Gene Ontology BP GO:0099623 3.48946081027745e-07 9.04610080520279e-07 745 969.454545454545 742 3.17223760340675e-08 301 2.3828265655415 2.5044644620039 1 13.3675823294958 742 1689 741 462 1719 1073 1201 699 301 520 1517 558 M12655 GO_BEHAVIORAL_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_PAIN.html Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 10/32 Gene Ontology BP GO:0048266 1.22878962746435e-07 3.84951540326431e-07 685 1170.54545454545 742 1.1170815419066e-08 120 1.92820249920757 2.19506035060884 1 11.4812968414886 681 1869 1518 2233 2772 742 583 120 590 1332 436 559 M13171 GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS.html The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. 20/73 Gene Ontology BP GO:0001658 1.22384098736076e-08 7.68916604102299e-08 2410 1339.54545454545 743 1.11258272197171e-09 40 2.43596883857257 2.69193460181882 1 16.0865198102856 2410 391 556 50 565 3552 2007 3273 40 743 1148 560 M13918 GO_RETINOIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. 6/33 Gene Ontology BP GO:0042573 1.15543855727215e-07 3.67949329315131e-07 745 1332.45454545455 743 1.15543861734888e-08 50 4.39353459956901 4.39353459956901 1 26.2408896545506 743 2246 4157 630 2643 986 179 132 349 2542 50 561 M10094 GO_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. 57/154 Gene Ontology BP GO:0016358 1.62330503979919e-08 9.07937622963925e-08 680 922.636363636364 744 1.47573186525182e-09 528 1.82134331092803 2.00177470965275 1 11.9056611055569 537 1775 970 1040 677 671 677 528 1189 1341 744 562 M14835 GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). 19/87 Gene Ontology BP GO:0007193 1.9704906949789e-08 1.02682247999855e-07 385 1063.09090909091 744 1.79135519329832e-09 266 2.02718957610858 2.02718957610858 1 13.1506662888699 381 1853 1401 2389 744 559 266 462 2048 1222 369 563 M10810 GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 530/1413 Gene Ontology BP GO:0045937 5.82058143684635e-09 5.0871514261604e-08 555 1059.90909090909 745 5.82058145209197e-10 76 1.74049203955875 1.99091310606582 1 11.7836184543234 553 745 3641 715 311 1297 979 502 2043 76 797 564 M12940 GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 530/1413 Gene Ontology BP GO:0010562 5.82058143684635e-09 5.0871514261604e-08 555 1102.09090909091 746 5.82058145209197e-10 77 1.74049203955875 1.99091310606582 1 11.7836184543234 554 746 3985 716 312 1298 980 613 2044 77 798 565 M14159 GO_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 625/1567 Gene Ontology BP GO:0009628 4.49028456616995e-09 4.49318776739808e-08 775 1063.09090909091 747 4.49028457524315e-10 80 1.88780319148708 2.2620681409175 1 12.8754441895655 775 253 4193 416 229 1760 956 700 1585 80 747 566 M15210 GO_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS.html Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. 46/117 Gene Ontology BP GO:0050764 1.86219079178299e-08 9.95252398516961e-08 495 960.818181818182 747 1.69290073413228e-09 392 1.88236032143463 1.88385193902099 1 12.2348357188082 495 1298 615 1487 719 789 627 392 2361 747 1039 567 M16709 GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 200/469 Gene Ontology BP GO:0071214 6.25740900269209e-09 5.30891555062659e-08 880 753.363636363636 749 5.68855365499081e-10 135 1.80429004926666 2.18463583230055 1 12.1845119817497 878 1203 597 931 304 1188 749 135 1633 529 140 568 M10927 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. 47/145 Gene Ontology BP GO:0048704 1.0321423114893e-09 1.71151312580172e-08 400 682.090909090909 750 9.38311192703208e-11 250 2.39696283998273 2.79016138973021 1 17.2807458121093 398 927 250 387 836 1166 750 781 529 306 1173 569 M10056 GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 283/699 Gene Ontology BP GO:0033674 2.25299536891506e-08 1.12118515518463e-07 580 805.545454545455 751 2.04817762907976e-09 345 1.70518246345098 1.93184403675359 1 11.0013240816432 576 751 423 689 803 955 906 1043 1725 345 645 570 M11688 GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle tissue development. 67/167 Gene Ontology BP GO:1901861 2.85890342251317e-09 3.65029676110884e-08 720 683.454545454545 751 2.59900311475302e-10 72 2.01604401154752 2.40681705254885 1 13.9189398072051 716 787 842 406 89 865 751 456 1291 1243 72 571 M10221 GO_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 75/226 Gene Ontology BP GO:0045471 5.23876192459791e-10 9.4277409363985e-09 1580 1125.18181818182 752 4.76251084167764e-11 237 2.50643431570238 2.83511291007644 1 18.6725040544311 1576 636 237 271 955 3062 1788 752 740 490 1870 572 M10833 GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. 13/34 Gene Ontology BP GO:0031290 1.72431227630288e-07 5.03204393392476e-07 705 907.909090909091 755 1.5675567376825e-08 122 2.18390775853582 2.1844711072811 1 12.7680244690701 703 1961 1012 300 1512 509 122 755 706 1286 1121 573 M10696 GO_SALIVARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SALIVARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. 18/55 Gene Ontology BP GO:0007431 2.00669294187273e-08 1.0352305921239e-07 800 762.909090909091 756 1.82426632743313e-09 192 1.58720097034314 1.79451462162504 1 10.2911796086184 799 192 1044 656 756 1027 711 560 972 614 1061 574 M14102 GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 37/103 Gene Ontology BP GO:0045912 4.16512110937234e-08 1.7282088749612e-07 760 787.727272727273 756 3.78647380747996e-09 212 1.76249976026149 2.18214010518637 1 11.0636721758849 756 532 685 1053 1014 1268 626 212 1382 786 351 575 M10164 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 7/24 Gene Ontology BP GO:0051968 3.53067472503545e-07 9.12796992603276e-07 1925 1317.72727272727 757 3.53067528599045e-08 42 2.54031060939399 2.82480330674295 1 14.241836303895 1922 236 3547 177 1760 2708 2508 329 42 509 757 576 M13935 GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 41/88 Gene Ontology BP GO:0043535 2.95717486451663e-08 1.36211933491575e-07 435 926.454545454545 761 2.6883408220601e-09 407 1.92699564778575 2.04739915090382 1 12.2811789160157 433 2615 1131 547 894 631 407 729 1005 1038 761 577 M10751 GO_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. 270/646 Gene Ontology BP GO:0030029 2.42807784738047e-11 5.24351881180815e-10 495 677.272727272727 762 2.20734349764297e-12 146 1.87506656783192 2.08534209519776 1 16.1529353271547 492 1109 200 409 453 856 762 944 1186 146 893 578 M16583 GO_HEMOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOSTASIS.html The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. 183/448 Gene Ontology BP GO:0007599 5.42162802878061e-09 4.96501359716536e-08 390 727 762 4.92875276558321e-10 284 1.92740814340383 2.28130787162936 1 13.0679757543223 390 1007 290 1093 1036 762 843 284 1104 464 724 579 M10678 GO_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 123/292 Gene Ontology BP GO:0002064 2.57979085564248e-14 8.74304302390366e-13 1185 1087 764 2.34526441422046e-15 125 2.37533444910451 2.41296411028947 1 26.5877347357632 1182 764 127 125 315 2391 1662 2474 572 216 2129 580 M12831 GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL.html Any process that modulates the potential difference across a post-synaptic membrane. 18/76 Gene Ontology BP GO:0060078 1.74105136333033e-07 5.05968581911612e-07 765 861 764 1.58277409192262e-08 416 2.13926938238933 2.22734845326492 1 12.5023256694027 764 688 1141 649 1517 1194 863 416 520 1104 615 581 M15683 GO_CARDIAC_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. 32/69 Gene Ontology BP GO:0060411 9.49120402176467e-09 6.64805736677504e-08 645 833.818181818182 764 8.6283673297377e-10 461 1.66674171508951 1.75004504211434 1 11.1044961006715 644 672 820 846 461 966 764 951 1781 579 688 582 M12937 GO_ENSHEATHMENT_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENSHEATHMENT_OF_NEURONS.html The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. 40/139 Gene Ontology BP GO:0007272 2.51435559801986e-09 3.40132659424763e-08 450 827.818181818182 765 2.28577781899408e-10 64 1.76719128027195 2.05996482024644 1 12.2511668479639 1064 140 895 512 64 1864 1670 1235 450 765 447 583 M13182 GO_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT.html Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. 40/139 Gene Ontology BP GO:0008366 2.51435559801986e-09 3.40132659424763e-08 1065 838.454545454545 766 2.28577781899408e-10 65 1.76719128027195 2.05996482024644 1 12.2511668479639 1065 141 896 513 65 1865 1671 1342 451 766 448 584 M16868 GO_CELLULAR_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 22/52 Gene Ontology BP GO:0071312 1.4280153717678e-07 4.33068280282031e-07 295 897.090909090909 766 1.29819587678181e-08 169 2.30393158830024 2.37483804985905 1 13.6091473371208 291 2047 766 1660 1451 350 213 609 1426 886 169 585 M13195 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. 102/225 Gene Ontology BP GO:2001236 1.95051327875148e-08 1.02102581986335e-07 935 727.272727272727 767 1.77319390549515e-09 80 1.93240211546285 2.31246984930286 1 12.5401768182266 931 767 466 779 739 1087 964 333 1315 539 80 586 M14234 GO_NEGATIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GROWTH.html Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. 136/323 Gene Ontology BP GO:0045926 1.54871607747452e-08 8.82555423854249e-08 530 965.090909090909 770 1.40792371670626e-09 284 1.78647614699651 1.9775617579373 1 11.6981637594628 527 1716 770 1665 659 761 854 487 1920 973 284 587 M11998 GO_FOREBRAIN_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_CELL_MIGRATION.html The orderly movement of a cell from one site to another at least one of which is located in the forebrain. 23/93 Gene Ontology BP GO:0021885 1.87652401197143e-07 5.381532419755e-07 600 775.818181818182 771 1.70593106548406e-08 103 2.23787285605701 2.38108138529397 1 13.0229486627768 600 821 856 103 2298 771 1079 155 273 1279 299 588 M13475 GO_RESPONSE_TO_ESTROGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTROGEN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 127/351 Gene Ontology BP GO:0043627 1.51503879102627e-13 4.53827426240966e-12 755 843.909090909091 771 1.37730799184216e-14 144 2.24692135330904 2.4604947796767 1 23.6586045657118 752 1014 144 642 579 1369 771 1162 1561 189 1100 589 M12916 GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. 95/216 Gene Ontology BP GO:0071559 3.05713959845884e-09 3.71578511927863e-08 720 836.636363636364 773 2.77921782064279e-10 274 2.24190505006531 2.37700752387713 1 15.4622328236557 717 773 274 443 778 1560 904 1103 549 417 1685 590 M13480 GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. 20/47 Gene Ontology BP GO:0000038 1.95057054106997e-08 1.02102581986335e-07 805 994.909090909091 773 1.77324596214925e-09 216 1.31156710912549 -1.05211787900109 -1 8.51131511356789 805 384 1770 1158 740 239 243 2450 216 2166 773 591 M14232 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. 515/1312 Gene Ontology BP GO:1902533 1.6436128165587e-08 9.14378372428713e-08 670 1230.72727272727 773 1.64361282871529e-09 278 1.69339240291386 1.99771292526385 1 11.0644526818473 666 1108 4210 768 706 1288 1067 773 1994 278 680 592 M12407 GO_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. 13/55 Gene Ontology BP GO:0050433 1.56920295294613e-08 8.86351497631251e-08 850 783.181818181818 774 1.42654814921713e-09 90 2.61253776565135 3.16628230128076 1 17.1028419567004 849 216 774 459 666 1498 1540 90 153 896 1474 593 M14226 GO_MONOSACCHARIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSPORT.html The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 26/83 Gene Ontology BP GO:0015749 5.48209829806552e-08 2.103585322142e-07 775 830.818181818182 774 4.98372584970173e-09 377 1.90077296574025 2.01216076954603 1 11.7810324056941 774 377 583 556 1109 1015 634 1730 597 945 819 594 M14392 GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoblast differentiation. 80/162 Gene Ontology BP GO:0045667 7.57597158075478e-09 5.8723265524949e-08 410 779.545454545455 774 6.88724691531235e-10 373 1.95127044062293 1.76309026524313 1 13.0977399049766 409 1028 505 438 373 843 821 1746 1121 517 774 595 M10666 GO_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COAGULATION.html Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. 48/144 Gene Ontology BP GO:0050818 1.20419750011747e-09 1.95492622134455e-08 260 964.090909090909 775 1.094725000706e-10 253 2.25454665276024 2.41742371692088 1 16.1331460060939 256 653 253 1434 2204 775 524 1026 1947 401 1132 596 M13117 GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 31/45 Gene Ontology BP GO:0010837 5.06535413442126e-08 1.98803374861521e-07 505 810.181818181818 776 4.60486750095243e-09 162 1.93193594287915 2.13514691873599 1 12.0181832149483 502 162 1074 1632 1085 900 776 621 477 1051 632 597 M16757 GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 51/105 Gene Ontology BP GO:0002088 4.05309540779363e-09 4.27430998519105e-08 480 1092.81818181818 776 3.68463219569156e-10 165 1.67433713604138 1.90264363548665 1 11.4532435826111 1295 338 598 480 165 1933 1174 2923 776 476 1863 598 M10935 GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 15/26 Gene Ontology BP GO:0071498 1.17064891531505e-07 3.71773113119548e-07 1115 895.545454545455 777 1.06422634327893e-08 255 1.82092850908609 2.0624673947851 1 10.8681150414546 1112 406 703 763 1383 1773 1074 255 482 1123 777 599 M12087 GO_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION.html The attachment of one cell to another cell via adhesion molecules. 290/888 Gene Ontology BP GO:0098609 2.033921397928e-29 8.58499731870882e-27 655 675.181818181818 777 1.84901945266182e-30 11 2.12240452970407 2.27826895763682 1 51.3542066657845 653 33 11 247 777 1499 1094 1048 860 23 1182 600 M12357 GO_DETECTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS.html The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. 20/46 Gene Ontology BP GO:0016048 6.78975641516586e-08 2.42872411676541e-07 975 972.727272727273 777 6.17250602246812e-09 288 2.36764505598821 2.23235269658235 1 14.537534250136 975 1234 601 777 1198 993 288 2956 466 562 650 601 M13940 GO_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell. 225/577 Gene Ontology BP GO:0040007 1.0371669493174e-08 6.96878588290404e-08 780 865.545454545455 777 9.42879049279099e-10 214 1.88236372166827 1.9735689877535 1 12.505301363853 777 469 367 214 503 1607 1291 1253 1398 284 1358 602 M14269 GO_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 17/53 Gene Ontology BP GO:0033280 1.07374135367239e-06 2.36722749529958e-06 420 1138 779 9.76128979752291e-08 419 2.23422896182299 2.43500748099264 1 11.6675054638825 419 1401 655 1584 2037 612 779 687 2450 1382 512 603 M14858 GO_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a second cell of the identical type via adhesion molecules. 40/108 Gene Ontology BP GO:0034109 2.47164151805925e-08 1.19664562756508e-07 780 810.636363636364 779 2.24694685984317e-09 474 2.65243805215121 2.90561826933854 1 17.043082357119 779 1451 474 916 841 668 639 1201 543 532 873 604 M13617 GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 19/45 Gene Ontology BP GO:0060314 1.35979339011595e-08 8.26377056323086e-08 780 1057.09090909091 780 1.23617581683697e-09 126 1.75962188556499 2.26684223093366 1 11.5689728463727 780 1315 1620 1110 599 733 523 126 1464 3025 333 605 M12819 GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 118/257 Gene Ontology BP GO:0051495 1.48607050332323e-08 8.70405107804676e-08 880 748.181818181818 781 1.35097319396494e-09 74 1.90560061725729 2.17254916388811 1 12.4888617141903 876 74 585 98 633 1214 724 1249 1070 926 781 606 M14753 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 457/1268 Gene Ontology BP GO:0051093 1.3011415523507e-19 1.13984909954044e-17 785 876.181818181818 781 1.18285595668245e-20 51 1.90879445909934 2.14372939029776 1 30.0208184637426 781 607 51 150 557 2133 1389 1091 1447 75 1357 607 M10530 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 50/150 Gene Ontology BP GO:0071347 6.50781592241477e-09 5.47387487821952e-08 565 1088.72727272727 783 5.91619631060503e-10 317 1.81209042601628 2.15826669396691 1 12.2148351724537 564 1944 783 1773 317 926 728 477 2346 1378 740 608 M13546 GO_KERATAN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 7/15 Gene Ontology BP GO:0042340 8.76855131884234e-08 2.95660012878613e-07 515 1023.45454545455 784 8.76855166483605e-09 299 2.29806673120282 2.66251274894983 1 13.9281115440632 531 437 4095 1011 1320 784 955 512 299 799 515 609 M15679 GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 96/308 Gene Ontology BP GO:0006140 2.04882346396026e-09 2.91800225250536e-08 785 856.636363636364 785 1.862566787153e-10 48 1.74848741658161 2.01404411099941 1 12.2295356601618 785 315 595 1113 48 1255 791 821 2442 555 703 610 M10047 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. 4/18 Gene Ontology BP GO:0036150 1.80124985600301e-07 5.22047633047563e-07 790 1193.81818181818 787 1.80125000200557e-08 75 2.08722671163046 -2.08722671163046 -1 12.171853882579 787 1347 3523 1399 2346 434 423 160 75 2067 571 611 M11569 GO_SARCOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOMERE_ORGANIZATION.html The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. 26/61 Gene Ontology BP GO:0045214 7.22138900119219e-09 5.77597192485712e-08 280 634.818181818182 790 6.56489911354184e-10 253 2.74909181569317 3.08498978022232 1 18.471384848815 279 813 294 253 1027 790 1083 826 285 456 877 612 M14579 GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 81/224 Gene Ontology BP GO:0050731 3.90715701597437e-08 1.64320018343922e-07 260 873.454545454545 790 3.5519609866952e-09 22 1.93617595373284 2.27430687282133 1 12.1932537236215 258 2085 790 2014 1214 68 225 87 1869 976 22 613 M14856 GO_MYELIN_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_ASSEMBLY.html The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. 9/30 Gene Ontology BP GO:0032288 5.22473881479302e-09 4.85311330456804e-08 795 1047.54545454545 791 5.22473882707707e-10 70 2.3195316560471 2.78931190087193 1 15.7479194037548 791 1180 4306 335 278 1460 892 364 70 1663 184 614 M10614 GO_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 202/549 Gene Ontology BP GO:0001101 2.32555080567351e-18 1.52077920996368e-16 1535 915.909090909091 792 2.11413709606682e-19 51 2.12062841658958 2.44717350933006 1 31.1374806487354 792 51 67 166 637 2184 1533 1535 1463 163 1484 615 M13978 GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 42/103 Gene Ontology BP GO:0061178 2.19403807260224e-08 1.09891248879096e-07 210 984.545454545455 793 1.99458008589379e-09 92 1.73251837869999 1.76109382310537 1 11.1917016317121 206 1992 1441 1500 793 270 92 437 2084 1367 648 616 M14992 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 742/1992 Gene Ontology BP GO:0048585 3.93923474221832e-09 4.21425504795384e-08 615 1076.90909090909 793 3.93923474920122e-10 191 1.71340278323975 2.04287555828394 1 11.7302445824623 611 599 4333 793 191 1293 805 387 1825 210 799 617 M14331 GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 29/118 Gene Ontology BP GO:0030816 1.40413176423237e-08 8.38685262762054e-08 430 1038.36363636364 797 1.27648343017648e-09 174 2.13109428004954 2.08991400463483 1 13.9985880660404 427 1733 797 2036 613 379 310 1643 2378 932 174 618 M15518 GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 25/58 Gene Ontology BP GO:0061001 9.74914549483243e-08 3.21621424699502e-07 270 973.181818181818 798 8.8628599335082e-09 238 1.97988997654286 1.9689063789298 1 11.9325295931954 270 2317 1497 1611 1324 353 238 533 798 1155 609 619 M16485 GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin receptor signaling. 33/96 Gene Ontology BP GO:0046626 7.82602600275725e-09 5.99607899848217e-08 615 1024.36363636364 801 7.11456911872423e-10 306 1.80351664062081 2.05672614034273 1 12.0907919970753 612 1047 1365 1855 384 403 551 801 1732 2212 306 620 M10771 GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 17/41 Gene Ontology BP GO:0043537 3.90267862920777e-07 9.88011825267811e-07 555 1136.36363636364 804 3.54789029229236e-08 290 1.93878655663125 2.09735901791638 1 10.8076021121301 551 2727 1628 962 1761 804 594 290 479 2246 458 621 M14911 GO_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of neuron death. 172/401 Gene Ontology BP GO:1901214 7.51497896536346e-09 5.86332115310401e-08 730 1010.45454545455 805 6.83179908275806e-10 368 1.74744641753711 2.02357329755163 1 11.7306692911082 730 2380 943 1299 368 805 703 514 1685 1217 471 622 M16233 GO_REGULATION_OF_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. 20/51 Gene Ontology BP GO:0060306 1.68267330355761e-07 4.94158896168119e-07 500 853.727272727273 806 1.52970312023377e-08 273 2.10343932017024 2.25303644865707 1 12.3129545226186 496 1311 642 273 1503 806 1088 965 800 432 1075 623 M13009 GO_TERPENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERPENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. 35/174 Gene Ontology BP GO:0006721 3.96957757668728e-09 4.2272359377429e-08 660 1038.72727272727 807 3.60870689440892e-10 22 2.53977700300098 2.97978448271611 1 17.3845930937851 657 2719 807 1437 1579 693 171 22 1205 2030 106 624 M12779 GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. 34/99 Gene Ontology BP GO:0060401 2.71201868372675e-07 7.31237093411341e-07 690 883.545454545455 809 2.46547183458823e-08 422 2.12506662875772 2.18888484308136 1 12.1038328321007 690 809 617 422 1659 1192 833 986 1089 672 750 625 M12509 GO_PROTEIN_TRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRIMERIZATION.html The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. 30/65 Gene Ontology BP GO:0070206 2.3600338393347e-08 1.16199757328007e-07 945 788.454545454545 810 2.14548533150163e-09 311 2.7648346155334 2.97936713387959 1 17.7980289554564 945 539 437 817 821 1490 774 1099 311 630 810 626 M16041 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 57/140 Gene Ontology BP GO:0090100 8.08663875549988e-09 6.09517268535486e-08 1360 1073.36363636364 811 7.35148980474934e-10 119 2.10808767200112 2.09966888675503 1 14.1187088270947 1358 119 433 330 401 2567 1554 1766 811 548 1920 627 M15624 GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. 293/689 Gene Ontology BP GO:0071900 1.80977357238195e-07 5.23864008514302e-07 825 1028.45454545455 812 1.64524883750759e-08 443 1.69684197876477 1.99631042358739 1 9.89291354991034 821 1830 735 695 1525 812 781 1000 1864 807 443 628 M14196 GO_SEGMENT_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENT_SPECIFICATION.html The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. 14/24 Gene Ontology BP GO:0007379 1.32709194292855e-06 2.84473125162385e-06 315 1022.45454545455 813 1.2064479486022e-07 313 2.49701365078559 3.14405875405306 1 12.8548403541992 1428 563 813 1123 2632 1252 740 315 313 724 1344 629 M13189 GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of stem cell differentiation. 36/92 Gene Ontology BP GO:2000738 8.64321863102335e-06 1.51664641359945e-05 275 1035.18181818182 814 7.85750235284734e-07 275 2.63595105508527 2.8614577858718 1 11.7916295299789 275 2128 487 1426 2553 862 937 643 506 756 814 630 M13613 GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. 11/24 Gene Ontology BP GO:0070884 1.04202144843705e-07 3.37620766580128e-07 715 950.181818181818 816 9.47292270719996e-09 691 2.19473711938183 2.53981915861716 1 13.1844298691599 715 707 897 1236 1348 793 725 1521 816 1003 691 631 M14420 GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION.html A cardiac conduction process that modulates the frequency or rate of heart contraction. 22/62 Gene Ontology BP GO:0086091 3.00994974234255e-06 5.82542586648456e-06 680 1231.18181818182 816 2.73632169130926e-07 384 2.48452439580788 2.40580731551287 1 12.0726302964256 676 2723 816 384 2323 884 679 2277 670 699 1412 632 M16570 GO_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_GROWTH.html The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. 88/205 Gene Ontology BP GO:0016049 3.27644071801043e-08 1.45019201656077e-07 710 927.181818181818 816 2.97858251527834e-09 545 1.76384585921126 1.94635606759092 1 11.1968367467254 708 1834 848 996 940 663 556 689 1604 545 816 633 M16935 GO_ACTIVATION_OF_MAPKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). 27/76 Gene Ontology BP GO:0000186 2.77650976051223e-07 7.45163862315509e-07 750 1049.18181818182 816 2.52410010083789e-08 359 1.51034763073561 1.8567910075293 1 8.59106416491317 749 816 1623 1561 1663 651 713 678 1095 1633 359 634 M10230 GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that activates or increases the frequency, rate or extent of reproductive process. 28/84 Gene Ontology BP GO:2000243 2.09923483319778e-09 2.97978954209262e-08 690 1279.45454545455 817 1.90839530472806e-10 51 2.06255367945828 2.49766299910586 1 14.4088028933815 1500 817 686 685 51 2511 1657 3442 567 687 1471 635 M10568 GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/97 Gene Ontology BP GO:0032890 8.51044343214728e-07 1.92563298515886e-06 775 989.181818181818 817 7.73676974937714e-08 583 2.3693022319692 2.67507495303391 1 12.5700857869702 773 808 745 845 1986 1240 1016 817 583 760 1308 636 M16717 GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of anion transport. 31/109 Gene Ontology BP GO:1903793 4.04911784636258e-07 1.02058478340232e-06 1025 1027.18181818182 817 3.68101690146018e-08 215 2.36609046443575 3.36602148954798 1 13.1586319567146 1021 538 646 499 1892 2227 1770 215 297 1377 817 637 M16216 GO_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_MIGRATION.html The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. 8/26 Gene Ontology BP GO:0014812 1.92117822106529e-08 1.01450865252488e-07 425 1324.36363636364 820 1.92117823767445e-09 55 2.00841962049183 2.00841962049183 1 13.0386713080438 422 2567 4528 2234 1927 273 55 59 820 1533 150 638 M16190 GO_PROTEIN_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HYDROXYLATION.html The addition of a hydroxy group to a protein amino acid. 11/20 Gene Ontology BP GO:0018126 1.37084473566816e-06 2.92905297179349e-06 740 1113.63636363636 821 1.24622326350697e-07 177 1.81857220596884 1.96599311956197 1 9.34075029372226 739 2189 1812 1050 3208 821 428 605 212 1009 177 639 M10483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. 23/50 Gene Ontology BP GO:0048662 5.18316957158317e-08 2.02060926287663e-07 495 889.818181818182 822 4.71197244881631e-09 493 2.05557619358934 1.84144986261852 1 12.7738557111476 493 822 846 1163 1092 799 619 1551 809 574 1020 640 M13463 GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 9/39 Gene Ontology BP GO:0086012 9.66332098641956e-07 2.15705766057433e-06 465 1312 826 9.66332518851189e-08 110 2.86666535058538 2.86666535058538 1 15.0776375795464 465 2372 4079 511 3049 826 609 300 110 1137 974 641 M10407 GO_RESPONSE_TO_ORGANOPHOSPHORUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANOPHOSPHORUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. 88/232 Gene Ontology BP GO:0046683 4.73399020624163e-09 4.60880543882876e-08 830 765.454545454545 827 4.30362746948026e-10 210 2.18634258311966 2.26628180942857 1 14.8891889127037 827 634 288 524 210 1052 829 1363 950 358 1385 642 M13534 GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. 5/22 Gene Ontology BP GO:0021514 1.93854894477633e-07 5.51512423443414e-07 830 1137.18181818182 829 1.93854911388509e-08 166 2.17756075894886 2.54990707168612 1 12.6504459687552 829 986 4093 1061 2947 628 339 166 355 854 251 643 M14328 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. 70/154 Gene Ontology BP GO:0048660 2.04013843019713e-08 1.04898812086437e-07 500 1009.45454545455 829 1.85467131737824e-09 391 1.87413327499605 1.88176289249602 1 12.1416324481553 497 784 671 829 760 1237 909 1592 2151 391 1283 644 M15832 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of endothelial cell proliferation. 44/103 Gene Ontology BP GO:0001938 1.26065819662896e-08 7.84616086722288e-08 920 999.909090909091 830 1.14605291259352e-09 575 2.15068768095044 2.05044084686541 1 14.185071149701 920 1523 688 961 575 691 706 1724 1587 794 830 645 M13649 GO_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REGENERATION.html The regrowth of lost or destroyed tissues. 31/80 Gene Ontology BP GO:0042246 1.00826874903188e-08 6.88439970846326e-08 1345 1009.81818181818 834 9.16607957866196e-10 369 2.154036375589 2.07259142154854 1 14.3207118593536 1159 369 725 446 486 1475 1344 2137 1345 834 788 646 M13724 GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of heart contraction. 22/57 Gene Ontology BP GO:0045823 1.02977544700664e-07 3.34586941949042e-07 590 966.272727272727 835 9.36159541098491e-09 45 2.36317459693732 2.630314043432 1 14.2048826570478 588 2091 835 770 1491 333 384 1160 1731 1201 45 647 M10832 GO_ADULT_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_BEHAVIOR.html Behavior in a fully developed and mature organism. 56/246 Gene Ontology BP GO:0030534 9.14596531099649e-09 6.53424683264709e-08 840 900.636363636364 837 8.31451395365327e-10 335 1.83733896639582 2.09189249256929 1 12.2538729704089 837 335 821 523 445 1098 945 1084 1128 618 2073 648 M11940 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. 50/126 Gene Ontology BP GO:0048640 3.07360590479123e-08 1.39362814608844e-07 790 922.727272727273 839 2.79418722521124e-09 392 2.26047200037564 2.47036108022791 1 14.3856593114056 790 1592 651 392 911 1364 696 1210 839 934 771 649 M12252 GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of muscle contraction. 27/61 Gene Ontology BP GO:0045933 8.989555026269e-08 3.00493189251022e-07 580 978.454545454545 839 8.17232308508797e-09 358 2.11188838722943 2.3624407415754 1 12.7859176634734 580 2000 839 920 1304 542 578 425 1872 1345 358 650 M15600 GO_LOCALIZATION_WITHIN_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_WITHIN_MEMBRANE.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. 83/194 Gene Ontology BP GO:0051668 2.46583830813496e-08 1.19633095764583e-07 1790 1364.45454545455 839 2.24167121433905e-09 95 1.79459979355312 2.33019628543349 1 11.5312840412646 1786 95 661 684 839 3758 2299 800 764 1426 1897 651 M12944 GO_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MORPHOGENESIS.html The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. 30/93 Gene Ontology BP GO:0048813 2.2812747598727e-07 6.31978443322731e-07 550 987.454545454545 840 2.07388636038904e-08 332 2.04178876041057 2.12711789691528 1 11.7495825894123 441 2355 1051 548 1606 546 332 840 639 1585 919 652 M14103 GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 14/30 Gene Ontology BP GO:0018146 7.24480656573647e-09 5.77966269496811e-08 840 779.909090909091 840 6.58618780872208e-10 210 2.14119929799769 2.36215032452963 1 14.3863511880215 840 210 461 1009 354 968 891 599 1414 523 1310 653 M13032 GO_EMBRYONIC_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PATTERN_SPECIFICATION.html The process that results in the patterns of cell differentiation that will arise in an embryo. 32/93 Gene Ontology BP GO:0009880 5.47697853981095e-09 4.97122471997677e-08 845 903.545454545455 841 4.9790714122237e-10 89 2.38839609721866 2.30140966016418 1 16.1923059028566 841 941 520 89 259 1653 1136 2123 320 578 1479 654 M16239 GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. 365/1026 Gene Ontology BP GO:0045596 1.77819179499803e-19 1.50111718257743e-17 845 819.454545454545 842 1.61653799545275e-20 53 1.94383881988805 2.1558380726307 1 30.3562378893666 842 265 53 151 358 2218 1448 868 1294 56 1461 655 M11730 GO_RRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_TRANSCRIPTION.html The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. 11/27 Gene Ontology BP GO:0009303 2.48389894927027e-08 1.2000772967182e-07 1455 1170.36363636364 843 2.25808997937692e-09 225 1.50039244235869 -1.33943756864459 -1 9.63894986552172 1451 712 2203 2074 843 476 680 225 595 2653 962 656 M13260 GO_APPENDAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APPENDAGE_DEVELOPMENT.html The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. 94/288 Gene Ontology BP GO:0048736 1.4162956323689e-08 8.41979592969118e-08 670 878.909090909091 843 1.28754149226055e-09 340 2.27048522141865 2.54872926865085 1 14.9106215740182 669 1122 340 532 619 1588 1050 1062 843 343 1500 657 M14599 GO_LIMB_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMB_DEVELOPMENT.html The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. 94/288 Gene Ontology BP GO:0060173 1.4162956323689e-08 8.41979592969118e-08 345 875.818181818182 844 1.28754149226055e-09 341 2.27048522141865 2.54872926865085 1 14.9106215740182 670 1123 341 533 620 1589 1051 1018 844 344 1501 658 M16202 GO_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 72/242 Gene Ontology BP GO:0044070 3.85054663192874e-07 9.78013567398529e-07 1150 1023.72727272727 846 3.50049755079113e-08 105 2.06274518768893 2.60199171761072 1 11.5070570633291 1148 105 506 505 1755 2073 1592 846 799 582 1350 659 M12884 GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. 32/73 Gene Ontology BP GO:0019935 4.81567404010066e-07 1.17741835535478e-06 100 745.363636363636 847 4.37788644929496e-08 47 1.90337749757095 2.05660147415412 1 10.4756404375906 100 1534 847 1369 2022 66 47 232 941 907 134 660 M15663 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. 34/90 Gene Ontology BP GO:1901379 7.25037430078873e-08 2.55219771634284e-07 525 1151.45454545455 847 6.59124958157626e-09 434 1.45282171193292 1.36494689906171 1 8.89140051981005 524 669 878 1899 1228 440 472 2711 2564 434 847 661 M12070 GO_POSITIVE_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASODILATION.html Any process that activates or increases the frequency, rate or extent of vasodilation. 12/43 Gene Ontology BP GO:0045909 4.50748021433304e-07 1.11438927769693e-06 550 1064.45454545455 851 4.09771012531862e-08 395 2.20503236097378 1.86257447166983 1 12.1847687490563 546 851 531 1239 1803 677 425 2270 1896 395 1076 662 M12866 GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. 959/2715 Gene Ontology BP GO:0071310 6.16164603282295e-09 5.24927018906367e-08 735 1192.54545454545 855 6.16164604990759e-10 253 1.76496410512834 1.99748426457952 1 11.9269799693191 732 740 3972 456 336 1655 1006 1283 1830 253 855 663 M14935 GO_GLIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. 5/16 Gene Ontology BP GO:0021781 4.13308310162467e-07 1.0372921535591e-06 855 1260.63636363636 855 4.13308387033178e-08 88 2.37469335672 2.81275053538097 1 13.1909306144572 847 1427 4320 854 1805 868 618 1982 88 855 203 664 M14669 GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. 170/456 Gene Ontology BP GO:0048871 8.38625041983573e-13 2.26380004065682e-11 550 793.272727272727 856 7.62386401803537e-14 158 2.15467882740482 2.37865163761448 1 21.2913870364443 550 477 158 803 1368 876 856 1004 1378 264 992 665 M16589 GO_ZYMOGEN_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_ACTIVATION.html The proteolytic processing of an inactive enzyme to an active form. 75/192 Gene Ontology BP GO:0031638 1.51081510277419e-08 8.7574463447947e-08 1675 1232.90909090909 857 1.37346828468134e-09 104 1.80825193303551 2.34657332042739 1 11.8464028905876 1672 104 603 857 643 3701 1996 783 1148 758 1297 666 M12397 GO_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 22/76 Gene Ontology BP GO:0090183 2.5820267484687e-08 1.2262767797456e-07 1770 1382.63636363636 858 2.34729707161148e-09 174 2.33363793164924 2.35766251072466 1 14.9716395482253 1766 174 428 188 858 2485 2099 3751 356 528 2576 667 M16849 GO_RESPONSE_TO_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. 50/150 Gene Ontology BP GO:0014823 1.92500995665394e-08 1.01450865252488e-07 700 1124.36363636364 859 1.75000906681624e-09 575 2.19149757060447 2.53024829284969 1 14.2272143934823 699 2769 871 1008 732 752 645 575 1838 1620 859 668 M13132 GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. 132/319 Gene Ontology BP GO:0043523 1.52451992627728e-08 8.78206701948561e-08 790 1060.36363636364 860 1.38592721531059e-09 647 1.83535489749227 2.14169085729245 1 12.0218853369736 788 2414 669 1079 647 1429 942 747 1240 849 860 669 M16782 GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 184/547 Gene Ontology BP GO:0034762 2.64405796555259e-08 1.25141295963921e-07 865 1004.72727272727 863 2.40368908848187e-09 56 1.61796212133192 1.7687586609682 1 10.3669296162822 863 56 522 840 863 1149 1354 1651 1980 236 1538 670 M14432 GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is increased. 14/50 Gene Ontology BP GO:0045777 2.75521757312014e-05 4.42340082710817e-05 865 1175.45454545455 865 2.50477461753474e-06 420 2.23259225798618 2.46311095243796 1 9.02383778050994 865 700 1468 1408 3313 909 685 731 420 1906 525 671 M13499 GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 10/37 Gene Ontology BP GO:0061037 1.38325986468157e-07 4.22757347390635e-07 385 887.272727272727 866 1.25750904695878e-08 54 1.65688308688593 1.74207755347862 1 9.80317703450047 382 1174 1378 1556 1441 132 65 2245 467 866 54 672 M10373 GO_CARDIAC_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_DEVELOPMENT.html The progression of a cardiac septum over time, from its initial formation to the mature structure. 56/145 Gene Ontology BP GO:0003279 1.08176058768166e-08 7.12427575688787e-08 820 905.727272727273 868 9.834187209098e-10 520 1.65293235464483 1.74928934415137 1 10.9663916479973 602 926 1089 816 520 895 820 1052 1519 856 868 673 M15848 GO_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 263/825 Gene Ontology BP GO:0043269 3.36271148011104e-13 9.5785701853715e-12 800 1028.09090909091 868 3.05701043646504e-14 41 1.80175197516685 2.05935954329887 1 18.4286904921452 798 41 152 791 868 1746 1628 1869 1671 63 1682 674 M15830 GO_POST_ANAL_TAIL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_ANAL_TAIL_MORPHOGENESIS.html The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. 18/44 Gene Ontology BP GO:0036342 1.07357782948199e-08 7.11073018870879e-08 790 1064.72727272727 869 9.75979849746307e-10 290 2.35388638152188 2.6624260986631 1 15.6186822517759 869 2425 1082 789 516 1553 503 789 290 1483 1413 675 M15877 GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the inflammatory response. 57/167 Gene Ontology BP GO:0050729 4.09662872363119e-09 4.28055816013327e-08 395 1361.18181818182 869 3.72420793750868e-10 170 2.18774238786699 2.42466001802261 1 14.9638856884562 1691 332 392 559 170 3239 1901 2831 869 392 2597 676 M13803 GO_COENZYME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 76/138 Gene Ontology BP GO:0009108 2.74400669720784e-08 1.28691142375111e-07 530 1613.81818181818 873 2.49455157403017e-09 86 1.06570966690979 -0.966260037761484 -1 6.81640999878245 530 505 2993 3134 873 86 558 1837 2917 3926 393 677 M16017 GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/55 Gene Ontology BP GO:0032892 2.6843943102509e-08 1.2679188995417e-07 660 919.727272727273 874 2.44035849364121e-09 65 2.4676225904917 3.16650474252632 1 15.7980083837862 658 1398 831 903 2073 1001 874 65 436 1224 654 678 M11508 GO_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_CYCLE.html Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 10/27 Gene Ontology BP GO:0042634 1.18671831932038e-05 2.03093739646316e-05 1185 1013.09090909091 875 1.07884065521277e-06 408 2.75821841386271 3.39459184143578 1 12.0138963204392 1185 1412 948 726 2751 892 577 875 507 863 408 679 M16575 GO_POSITIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXONOGENESIS.html Any process that activates or increases the frequency, rate or extent of axonogenesis. 46/107 Gene Ontology BP GO:0050772 5.16839459980163e-09 4.82163228585794e-08 460 923.909090909091 875 4.69854055631234e-10 202 1.78498660351081 2.17095928601145 1 12.1234334002775 458 2126 1184 1522 244 441 875 297 1196 1618 202 680 M11578 GO_ADULT_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_LOCOMOTORY_BEHAVIOR.html Locomotory behavior in a fully developed and mature organism. 40/161 Gene Ontology BP GO:0008344 1.59552618508811e-08 8.96855699438753e-08 775 956 877 1.45047836059954e-09 576 1.67320882370905 1.913196833767 1 10.945627113695 771 1138 1276 855 671 863 877 576 1155 954 1380 681 M10989 GO_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 428/1046 Gene Ontology BP GO:0043549 1.07944065489336e-08 7.11909511458791e-08 890 907.545454545455 879 9.8130969108154e-10 495 1.69232191989551 1.94584406129545 1 11.228218300067 887 997 495 613 519 1399 1052 733 1909 500 879 682 M15331 GO_FLAVONOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVONOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. 4/29 Gene Ontology BP GO:0009812 5.59455032594747e-09 5.02427411283832e-08 5 1113.27272727273 879 5.594550340032e-10 2 4.39353459956901 4.39353459956901 1 29.7674882494847 879 1501 4389 128 1408 1141 493 211 2 2092 2 683 M16753 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. 9/16 Gene Ontology BP GO:2000727 5.00928137436927e-08 1.96818485411937e-07 885 1258 881 5.00928148728732e-09 333 2.74441429849224 3.22332304120646 1 17.083548800678 881 724 4616 542 1111 1339 1388 568 333 1671 665 684 M12693 GO_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PAIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 14/52 Gene Ontology BP GO:0048265 9.97768045698133e-05 0.00014683477135266 725 1245.18181818182 883 9.07103000398667e-06 698 2.36435802726387 2.29722026674691 1 8.41280023623695 723 698 819 1767 3029 921 795 2168 883 1019 875 685 M16208 GO_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 56/135 Gene Ontology BP GO:0006970 4.24006450257007e-09 4.33682206598416e-08 1330 886.727272727273 883 3.85460410067452e-10 124 1.74930611186711 2.13544088879355 1 11.9558271303996 1329 124 883 604 183 1439 1308 717 1393 857 917 686 M12958 GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA.html Any process of the innate immune response that takes place in the mucosal tissues. 16/97 Gene Ontology BP GO:0002227 1.9164994823034e-05 3.15766752886256e-05 360 1121.90909090909 884 1.74228743438764e-06 254 1.8623734102804 -1.8623734102804 -1 7.78053662406001 357 1684 775 1621 2976 264 254 1124 2038 364 884 687 M14661 GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. 26/59 Gene Ontology BP GO:0050775 7.34326858771541e-08 2.57899008891808e-07 245 1000.36363636364 884 6.6756989389297e-09 162 1.74091871333463 1.92478611375388 1 10.6472510702599 243 2513 1704 1532 1233 220 162 525 884 1577 411 688 M13427 GO_ENDOTHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 58/132 Gene Ontology BP GO:0003158 5.39368094169284e-07 1.29688558323562e-06 140 1027.81818181818 885 4.90334751277051e-08 136 2.36973924544621 2.42546015635121 1 12.9500363270738 136 2612 391 1045 2844 297 222 885 1285 1189 400 689 M13485 GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. 190/457 Gene Ontology BP GO:0071902 2.72420568596511e-07 7.33831452516508e-07 730 1130.09090909091 885 2.47655093026985e-08 541 1.69310896388026 2.01732918081579 1 9.64109569712883 729 1715 771 541 1660 1187 885 1407 1885 808 843 690 M14434 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. 11/34 Gene Ontology BP GO:0060045 7.62097341951069e-10 1.32525017178982e-08 740 927.363636363636 885 6.92815765650058e-11 4 2.80043913797314 3.0481628460093 1 20.4783438948952 885 1565 738 615 4 1269 737 1821 537 1004 1026 691 M11815 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. 70/161 Gene Ontology BP GO:0097202 1.86274894316442e-08 9.95252398516961e-08 1040 934.727272727273 886 1.69340814448762e-09 109 1.7783712329078 2.34657332042739 1 11.5589346060468 1039 109 700 886 720 2363 1270 314 1158 987 736 692 M15890 GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). 22/109 Gene Ontology BP GO:0007189 1.22836392114477e-08 7.70344480881349e-08 765 1155 889 1.11669448000301e-09 567 2.09992373783379 1.83280449252252 1 13.8657926461254 763 1308 889 1590 567 1139 879 2479 1672 700 719 693 M16887 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. 152/394 Gene Ontology BP GO:0032102 7.96132785476061e-09 6.04982736982873e-08 430 893.181818181818 893 7.23757080324631e-10 337 1.87007801279438 2.13109009799955 1 12.530292268785 430 1115 337 567 395 1287 893 1129 1841 363 1468 694 M14129 GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. 158/476 Gene Ontology BP GO:0072507 5.45754740936615e-09 4.97122471997677e-08 525 971.363636363636 896 4.9614067480952e-10 291 1.86249896477714 1.9917335512386 1 12.6269478121013 522 1009 291 844 511 987 896 1976 2135 479 1035 695 M11069 GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of epithelial cell migration. 117/251 Gene Ontology BP GO:0010632 4.55093787585006e-08 1.84404546230612e-07 325 811.363636363636 905 4.13721633635558e-09 258 1.85061210540217 1.91451545731266 1 11.5683754117275 323 905 336 388 1352 908 630 1060 1530 258 1235 696 M15082 GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. 261/608 Gene Ontology BP GO:0042326 2.92460043013175e-09 3.65029676110884e-08 1220 936.090909090909 907 2.65872766729055e-10 98 1.6096906827357 1.89585264862305 1 11.113441725497 817 1001 1084 1217 98 907 799 803 1780 1218 573 697 M11938 GO_RESPONSE_TO_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METAL_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 199/517 Gene Ontology BP GO:0010038 2.07250271821297e-12 5.14579150837583e-11 1305 1056.72727272727 909 1.88409338019538e-13 173 1.98514796523347 2.35216452077169 1 18.9590294302376 1302 286 173 418 812 2690 1731 909 1556 313 1434 698 M15094 GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. 8/26 Gene Ontology BP GO:0043567 5.57884901081347e-09 5.0198829374432e-08 555 1276.54545454545 909 5.57884902481907e-10 25 3.7869012022049 3.7869012022049 1 25.6587035109184 555 1492 4351 909 2008 781 994 25 73 2146 708 699 M10632 GO_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 32/93 Gene Ontology BP GO:0061035 3.06156773463702e-08 1.38980425859901e-07 935 1042 910 2.78324343385678e-09 476 1.7936244202543 1.90237166243741 1 11.416624801729 954 671 932 476 910 1106 633 3425 932 577 846 700 M11804 GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE.html The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. 5/17 Gene Ontology BP GO:0048846 8.45140413537442e-05 0.000125482221209891 455 1364.81818181818 910 8.45172557062293e-06 443 3.19323515449037 3.19323515449037 1 11.5643838286625 451 1345 3809 1360 3042 642 687 910 443 1499 825 701 M16787 GO_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). 53/155 Gene Ontology BP GO:0003014 1.83497555647688e-07 5.28523046446783e-07 360 992.090909090909 910 1.668159735935e-08 359 1.76648605880087 1.83776104103476 1 10.2926464094372 359 513 453 1052 1536 910 675 1623 2011 643 1138 702 M10724 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 21/68 Gene Ontology BP GO:0051966 3.15384286260889e-07 8.28709247939619e-07 1345 1270.63636363636 912 2.86713028612076e-08 360 2.39038579676355 2.45138095515979 1 13.4944389083163 1344 551 666 381 1698 2728 2685 912 360 624 2028 703 M10964 GO_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of dendrite morphogenesis. 46/125 Gene Ontology BP GO:0048814 7.79959275821925e-08 2.69045387640505e-07 290 944.636363636364 912 7.09053912248714e-09 183 1.74457592259823 1.88851899096407 1 10.6398598947129 289 2127 1642 1604 1259 183 214 664 912 1114 383 704 M12333 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 79/210 Gene Ontology BP GO:0090288 1.52639980911065e-09 2.37821285694655e-08 680 853.090909090909 912 1.38763619106335e-10 23 1.81935598736439 1.95400079428251 1 12.8752427182546 680 912 935 444 23 1465 1181 526 1264 1046 908 705 M10902 GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any neuron projection extension that is involved in neuron projection guidance. 5/17 Gene Ontology BP GO:1902284 8.55688063499893e-05 0.000126891078851166 450 1349.81818181818 913 8.55721014378424e-06 442 3.19323515449037 3.19323515449037 1 11.5500109894351 450 1344 3655 1359 3041 641 686 913 442 1493 824 706 M10246 GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. 57/204 Gene Ontology BP GO:1900544 1.57527850195464e-09 2.42186029290577e-08 835 985.181818181818 914 1.43207136643873e-10 27 1.95826058098861 2.10960617268495 1 13.8438871822557 834 1132 578 827 27 1357 914 1219 2465 546 938 707 M13363 GO_POSITIVE_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HAIR_CYCLE.html Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 5/13 Gene Ontology BP GO:0042635 9.12744017935027e-07 2.0542270844752e-06 1100 1277.63636363636 914 9.12744392830983e-08 74 2.52695080725176 2.83764541876496 1 13.340619485984 1098 735 4061 914 2430 507 74 1879 1322 853 181 708 M13998 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 57/204 Gene Ontology BP GO:0045981 1.57527850195464e-09 2.42186029290577e-08 835 982 915 1.43207136643873e-10 28 1.95826058098861 2.10960617268495 1 13.8438871822557 835 1133 579 828 28 1358 915 1174 2466 547 939 709 M12628 GO_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CONTRACTION.html A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. 128/347 Gene Ontology BP GO:0006936 1.54549001649149e-14 5.47764133325952e-13 490 821.636363636364 916 1.40499092408318e-15 121 2.29545847806 2.62423284785941 1 26.1263576482594 490 1210 121 703 915 916 982 1546 1059 155 941 710 M13797 GO_RESPONSE_TO_AUDITORY_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AUDITORY_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. 16/48 Gene Ontology BP GO:0010996 4.17254042127234e-09 4.30928737311998e-08 980 847.545454545455 916 3.79321857198729e-10 96 2.77660686482349 2.85604568196484 1 18.9841579696524 980 1553 758 293 177 1807 1487 96 227 916 1029 711 M16268 GO_NEGATIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DEATH.html Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. 114/276 Gene Ontology BP GO:1901215 1.11867485995303e-08 7.26434597868799e-08 1015 937.545454545455 916 1.01697715058306e-09 316 1.79746058472041 2.08209140709259 1 11.911156676904 1014 1587 682 786 533 1264 1081 316 1349 785 916 712 M16803 GO_NEUROPEPTIDE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. 18/105 Gene Ontology BP GO:0007218 6.27648287565023e-08 2.30162001994041e-07 920 1008.09090909091 916 5.70589368610449e-09 618 3.17470864688252 3.08121828566526 1 19.5617660498691 916 1550 618 673 1169 1102 649 1818 712 1113 769 713 M10421 GO_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a gland are generated and organized. 69/166 Gene Ontology BP GO:0022612 1.88155058604212e-08 1.00298959483279e-07 1310 1096.72727272727 918 1.71050054739462e-09 237 1.97162505368221 2.00953026071865 1 12.8088772281694 1310 918 374 529 724 2071 1371 1714 465 237 2351 714 M10876 GO_NEGATIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. 108/243 Gene Ontology BP GO:0030308 3.59513128633137e-08 1.55710770171983e-07 370 1014.81818181818 919 3.26830122280113e-09 236 1.77000894255508 1.96648979089353 1 11.1852015457544 366 2210 919 2271 966 384 483 267 1945 1116 236 715 M14023 GO_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 69/211 Gene Ontology BP GO:0042471 1.06043033846352e-08 7.04374543846373e-08 405 864.454545454545 919 9.64027585068131e-10 301 2.18814350854966 2.55684194759588 1 14.527281976931 402 919 301 490 809 1045 972 1134 1743 503 1191 716 M13645 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. 18/34 Gene Ontology BP GO:1900078 3.50369124521736e-07 9.07541244238639e-07 840 1039.36363636364 921 3.18517436655524e-08 329 1.54685993168828 1.69577502060459 1 8.67581830396568 838 397 1676 1289 1720 635 329 930 921 1931 767 717 M11901 GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of cell proliferation. 449/1274 Gene Ontology BP GO:0008284 2.4878825772726e-15 9.87285368057837e-14 970 852 927 2.26171143388418e-16 53 1.80100626894615 2.06698545169363 1 21.7426927855655 967 260 108 503 290 2130 1155 927 1773 53 1206 718 M13957 GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of glucose across a membrane. 6/22 Gene Ontology BP GO:1904659 1.23999266089831e-05 2.11431726939069e-05 385 1186.18181818182 928 1.23999958007074e-06 198 1.93901018554944 1.93901018554944 1 8.41424260928218 385 594 4165 1088 2654 429 198 928 576 1080 951 719 M15758 GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY.html Any process that initiates the activity of an inactive protein kinase. 166/415 Gene Ontology BP GO:0032147 1.6096239420366e-08 9.03686089827805e-08 930 1029 928 1.4632945034667e-09 441 1.6712979708349 1.84543845108345 1 10.928014997879 928 476 510 680 673 1570 1401 1990 1571 441 1079 720 M10665 GO_KERATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 17/38 Gene Ontology BP GO:0042339 1.01333837162096e-08 6.89872442732571e-08 930 861.454545454545 929 9.21216705716805e-10 401 1.97088409458931 2.27662965616174 1 13.1014063090644 929 401 534 1044 489 1228 1281 594 1373 549 1054 721 M10229 GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. 88/229 Gene Ontology BP GO:0043524 1.57225759676783e-08 8.8699781552771e-08 1190 943.454545454545 930 1.42932509818561e-09 466 1.86383249139025 2.21530339018335 1 12.2009342468372 1190 1025 629 885 667 1779 1137 466 930 949 721 722 M13833 GO_POSITIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEATH.html Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 414/961 Gene Ontology BP GO:0010942 5.74564770137226e-09 5.07168104134438e-08 895 1036.09090909091 931 5.22331610579813e-10 277 1.70001349266227 1.99716494900572 1 11.5116546942225 894 1270 467 853 277 1974 1255 931 1918 488 1070 723 M14282 GO_METANEPHRIC_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. 9/23 Gene Ontology BP GO:0072075 6.41983559986976e-08 2.32962958353193e-07 935 958.454545454545 932 6.41983578533405e-09 78 2.59109773883629 2.79143852620148 1 15.9530654138274 932 226 4216 137 1218 974 1141 310 78 325 986 724 M14682 GO_KIDNEY_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. 9/27 Gene Ontology BP GO:0072074 6.41983559986976e-08 2.32962958353193e-07 935 964 933 6.41983578533405e-09 79 2.59109773883629 2.79143852620148 1 15.9530654138274 933 227 4273 138 1219 975 1142 305 79 326 987 725 M11130 GO_GLIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DEVELOPMENT.html The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 46/123 Gene Ontology BP GO:0021782 8.97727956830361e-09 6.49122746872391e-08 440 1107.27272727273 934 8.16116327721465e-10 438 1.75276652003197 2.23033998305323 1 11.6944964124864 1343 934 1155 447 439 2513 2085 1077 438 918 831 726 M12106 GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY.html The disaggregation of a beta-catenin destruction complex into its constituent components. 12/34 Gene Ontology BP GO:1904886 3.86585061914928e-07 9.80924353855349e-07 420 1232.45454545455 934 3.51441027132599e-08 212 1.51077491165636 1.68013523520844 1 8.42607200678368 420 2732 1728 934 1756 438 212 577 3133 1171 456 727 M11198 GO_HEXOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. 6/22 Gene Ontology BP GO:0035428 1.23999266089831e-05 2.11431726939069e-05 385 1143.81818181818 936 1.23999958007074e-06 197 1.93901018554944 1.93901018554944 1 8.41424260928218 384 593 3705 1087 2653 428 197 936 575 1074 950 728 M15515 GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 21/58 Gene Ontology BP GO:0071470 3.8413193731407e-09 4.15796396971137e-08 1930 1156.90909090909 938 3.4921085271344e-10 153 1.63923317440728 1.96027366296603 1 11.2313533947241 1930 182 938 748 153 2736 1909 1073 635 813 1609 729 M16074 GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. 103/259 Gene Ontology BP GO:0030178 2.75268981768025e-07 7.39198312521077e-07 940 1180.36363636364 939 2.50244560191191e-08 182 1.89089056423036 2.20304887204691 1 10.7617717473312 939 1282 898 600 2170 2744 1342 182 638 1403 786 730 M14037 GO_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 491/1440 Gene Ontology BP GO:0033993 1.66645711857372e-28 5.95181569349062e-26 940 969.727272727273 940 1.51496101688519e-29 13 2.03368968120291 2.24937200381037 1 47.6201802837709 940 890 13 262 571 2248 1178 1257 1821 69 1418 731 M16223 GO_ADAPTATION_OF_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTATION_OF_SIGNALING_PATHWAY.html The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. 11/26 Gene Ontology BP GO:0023058 1.28745337358308e-08 7.99150536570355e-08 1530 1087.36363636364 940 1.17041216465213e-09 580 2.10669909455563 2.08267101269812 1 13.8793515732209 1529 705 1032 980 580 1640 940 2064 890 707 894 732 M15186 GO_ENDOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_SYSTEM_DEVELOPMENT.html Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. 54/165 Gene Ontology BP GO:0035270 6.6745507753869e-09 5.50177850965416e-08 2415 1519.54545454545 941 6.06777345057884e-10 329 1.94099864433178 2.40603815286315 1 13.0797936199891 2415 648 607 489 329 4018 2368 906 1154 941 2840 733 M12510 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. 79/170 Gene Ontology BP GO:0033135 3.10290690035536e-08 1.40073413968129e-07 435 935.181818181818 943 2.82082449465376e-09 19 1.76007394173494 1.96171300105019 1 11.1975138346399 432 1982 1207 1297 943 186 391 786 1794 1250 19 734 M15261 GO_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. 151/410 Gene Ontology BP GO:0050727 1.5873218013975e-09 2.43232182306554e-08 945 943.636363636364 943 1.44301982049343e-10 29 1.85990484218486 2.03336453052672 1 13.1453312136209 686 902 409 943 29 1693 1024 943 1762 486 1503 735 M11649 GO_TONGUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TONGUE_DEVELOPMENT.html The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. 4/29 Gene Ontology BP GO:0043586 1.9935237198317e-06 4.03484334401857e-06 945 1567.18181818182 944 1.99352550819553e-07 98 3.50118099020073 3.50118099020073 1 17.5310769419894 944 2841 3782 1920 3185 595 98 861 452 2075 486 736 M12364 GO_NEURAL_CREST_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_MIGRATION.html The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. 24/70 Gene Ontology BP GO:0001755 1.29845823043743e-06 2.79108405737084e-06 945 1264.54545454545 945 1.18041726981716e-07 694 1.75883927253255 2.18068427099694 1 9.06815466162175 719 945 694 944 2091 1703 929 2023 1772 789 1301 737 M14188 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 68/153 Gene Ontology BP GO:0007179 6.57002937896544e-09 5.47858747037603e-08 950 971.454545454545 946 5.97275399871458e-10 320 2.04276406534402 2.31433907845916 1 13.7690381518215 946 1290 731 545 320 1830 1021 849 475 1284 1395 738 M14446 GO_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_REGENERATION.html The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. 19/47 Gene Ontology BP GO:0031102 7.55011901864702e-07 1.73626560691323e-06 620 968.636363636364 946 6.86374691795699e-08 399 1.69380712878255 1.80740533520129 1 9.05700300853121 616 399 1069 849 1950 1059 1053 1154 946 691 869 739 M12906 GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 26/75 Gene Ontology BP GO:0086065 2.85371984265341e-06 5.56014319321853e-06 650 1202.72727272727 947 2.59429413122695e-07 581 2.09335220704943 1.96576031550151 1 10.2112063619885 648 1848 954 1094 2309 814 947 2551 689 581 795 740 M10509 GO_RESPONSE_TO_ESTRADIOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTRADIOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 82/226 Gene Ontology BP GO:0032355 2.69040497972477e-12 6.58358863661205e-11 955 847.272727272727 951 2.44582270884369e-13 175 2.42902335160657 2.84205776207463 1 22.9569498518182 951 1026 175 382 625 1969 962 753 1191 276 1010 741 M12683 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin receptor signaling. 10/20 Gene Ontology BP GO:0046628 6.02544567684526e-07 1.42735429987717e-06 955 1128.54545454545 952 5.47767938828949e-08 429 1.46884774346342 1.53965959945316 1 7.9701265042581 952 429 1527 1226 1884 725 608 1506 915 1867 775 742 M12974 GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 16/43 Gene Ontology BP GO:0071377 4.06840830727129e-07 1.0243828509035e-06 565 1219.63636363636 952 3.69855369057516e-08 204 1.83735980888558 1.67076070322922 1 10.2154299175688 562 204 854 1357 1771 952 793 3261 1314 915 1433 743 M13154 GO_CELLULAR_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 20/64 Gene Ontology BP GO:0071320 3.40239239061361e-08 1.4903120631716e-07 810 1542.54545454545 952 3.09308403930277e-09 487 1.47905467514223 1.46310340444922 1 9.37271969273011 809 2360 1947 2681 952 646 487 739 2457 3162 728 744 M13341 GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of chondrocyte differentiation. 22/71 Gene Ontology BP GO:0032330 4.35484538029476e-08 1.79251304084296e-07 1380 1316.81818181818 952 3.95895042408896e-09 603 1.7530165640637 1.77962541627345 1 10.978325518831 1378 952 1156 603 1021 1483 935 4525 790 698 944 745 M15546 GO_ACTIN_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 118/243 Gene Ontology BP GO:0007015 1.82376594913885e-08 9.84621546726941e-08 1145 942.545454545455 952 1.657969058416e-09 442 1.84010491955794 2.15165331576993 1 11.9681533438368 1145 626 470 594 711 1695 988 1404 952 442 1341 746 M15095 GO_RESPIRATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_DEVELOPMENT.html The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. 114/307 Gene Ontology BP GO:0060541 5.73154302662915e-09 5.06886748050269e-08 955 1065.72727272727 953 5.21049367414656e-10 77 1.91258851337566 1.91805624077117 1 12.9515359973413 953 77 305 332 275 1982 1396 3057 1687 294 1365 747 M14752 GO_MULTICELLULAR_ORGANISMAL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_SIGNALING.html The transfer of information occurring at the level of a multicellular organism. 50/189 Gene Ontology BP GO:0035637 1.30456893115058e-06 2.80162513752643e-06 700 1105.81818181818 954 1.18597245885652e-07 453 2.26195617210695 2.36731909765577 1 11.6586677258579 698 2259 555 598 2092 1009 954 1635 680 453 1231 748 M10890 GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. 30/70 Gene Ontology BP GO:0045600 1.55007713698025e-07 4.64622862943791e-07 725 1174.90909090909 959 1.40916113290517e-08 322 2.05261302715804 2.07624006285026 1 12.0664302440534 724 3340 1198 959 1473 649 682 322 1570 1584 423 749 M14370 GO_RESPONSE_TO_CORTICOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. 12/34 Gene Ontology BP GO:0051412 1.58343716645777e-05 2.64742483394434e-05 225 917.272727272727 959 1.43949869388113e-06 218 2.59929320609641 2.59929320609641 1 11.0438894909597 221 1328 959 1277 2693 348 218 1001 324 1178 543 750 M12601 GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 278/886 Gene Ontology BP GO:0032870 7.83179924483416e-10 1.35178601835558e-08 965 1021 961 7.11981749783837e-11 245 1.90846964911289 2.01719737127153 1 13.9405214532116 961 467 245 272 540 1751 1246 2457 1696 504 1092 751 M10875 GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. 19/37 Gene Ontology BP GO:0032793 3.33615342295715e-08 1.469616730815e-07 130 906 963 3.03286679413426e-09 10 1.67082911003115 1.67082911003115 1 10.5974070512225 126 1681 1489 1117 1739 87 10 386 963 2054 314 752 M14116 GO_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_MIGRATION.html The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. 27/59 Gene Ontology BP GO:0008347 2.93486265948086e-07 7.80444864144881e-07 535 911.090909090909 963 2.66805731909088e-08 112 1.97790621635143 2.05770097635068 1 11.2137152599672 533 1901 1163 963 1676 478 112 1218 803 1034 141 753 M10474 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE.html Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. 8/21 Gene Ontology BP GO:0090178 3.39519010068635e-08 1.48856162771357e-07 540 1267.63636363636 964 3.39519015255927e-09 536 1.75337189156389 1.75471297804809 1 11.1118894117807 536 1258 3593 818 985 664 760 1419 2222 964 725 754 M15418 GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. 25/55 Gene Ontology BP GO:2000249 1.5623742608728e-07 4.67704944760309e-07 575 1001.63636363636 964 1.42034033802541e-08 152 2.1450532509027 2.51980482753671 1 12.6041292182533 571 1055 945 1428 1475 964 872 152 1639 1154 763 755 M10607 GO_INTERMEDIATE_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_ORGANIZATION.html Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 12/32 Gene Ontology BP GO:0045109 1.10896419977194e-05 1.90983708439952e-05 680 1150.45454545455 968 1.00815435438058e-06 492 3.06425135334951 3.06230820853765 1 13.4228222167651 678 1563 492 1122 2722 848 699 1421 1370 772 968 756 M11169 GO_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORT.html A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 78/301 Gene Ontology BP GO:0098656 3.64884059218153e-08 1.57157392110379e-07 870 1133.72727272727 973 3.31712786609081e-09 480 1.7101685301098 1.82834691676786 1 10.8006769885945 867 910 886 1793 973 1716 1161 1622 1579 480 484 757 M11325 GO_MATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING.html The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. 13/48 Gene Ontology BP GO:0007618 2.7366366701568e-08 1.28555726231123e-07 1400 1093.72727272727 977 2.48785154927139e-09 375 2.10481844765296 2.2527678466999 1 13.463571002835 1398 566 684 977 871 1370 1817 1775 375 465 1733 758 M15489 GO_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 36/79 Gene Ontology BP GO:0046677 1.24429340190421e-07 3.88517435443257e-07 950 1274.81818181818 977 1.13117588389086e-08 121 2.15331612302038 2.60492313723841 1 12.8137101090791 950 2175 977 491 2613 2035 1187 121 962 2109 403 759 M14996 GO_DEVELOPMENTAL_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_CELL_GROWTH.html The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. 49/120 Gene Ontology BP GO:0048588 6.13856487423838e-07 1.45266853777211e-06 685 1372.54545454545 981 5.58051507914206e-08 574 1.57667654623834 1.6664747795456 1 8.54404331385608 684 2173 1567 2360 1888 650 574 971 2376 874 981 760 M12127 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an external stimulus. 156/449 Gene Ontology BP GO:0032103 3.26843729999681e-09 3.84357595519315e-08 890 959.363636363636 982 2.97130664077507e-10 60 1.83184205284707 2.05042022201056 1 12.609091858234 886 60 277 982 120 1832 1437 1156 1845 265 1693 761 M13253 GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT.html The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. 64/205 Gene Ontology BP GO:0060538 7.04486364361335e-07 1.63383126360124e-06 985 1081.90909090909 983 6.40442354502561e-08 484 2.52458830167001 2.82942319902924 1 13.5611847773177 614 2037 484 983 1930 1328 949 887 647 1057 985 762 M14929 GO_HEART_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_PROCESS.html A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 63/167 Gene Ontology BP GO:0003015 1.1135819932377e-07 3.56576634110527e-07 975 1175.45454545455 983 1.01234731782208e-08 325 2.49084520584064 2.72865229138508 1 14.9083852522721 972 1519 357 325 1369 1667 983 2772 656 383 1927 763 M15093 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. 11/16 Gene Ontology BP GO:0010667 8.57300560054918e-08 2.90884951860782e-07 1085 838.727272727273 984 7.79364175874896e-09 94 2.12972362706975 2.55600278669554 1 12.9217980444419 1083 574 1250 1136 1282 984 244 737 389 1453 94 764 M10502 GO_FOCAL_ADHESION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOCAL_ADHESION_ASSEMBLY.html The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. 22/40 Gene Ontology BP GO:0048041 1.10632110448494e-08 7.22454133350714e-08 535 877.636363636364 986 1.0057464636803e-09 525 2.03266928360985 2.31804451624107 1 13.4743067858967 534 1062 1006 986 525 1162 1119 566 1047 883 764 765 M12752 GO_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. 53/141 Gene Ontology BP GO:0060070 2.04840469497096e-08 1.04975088286426e-07 850 1097.72727272727 987 1.86218610367593e-09 749 1.99595507422145 2.04474520534306 1 12.9302740120794 850 1723 784 887 762 1637 1019 1217 987 749 1460 766 M14304 GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction. 22/40 Gene Ontology BP GO:0007045 1.10632110448494e-08 7.22454133350714e-08 535 881.818181818182 987 1.0057464636803e-09 526 2.03266928360985 2.31804451624107 1 13.4743067858967 535 1063 1007 987 526 1163 1120 601 1048 885 765 767 M10713 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN.html The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. 17/37 Gene Ontology BP GO:0050965 3.22052410453439e-07 8.42416530555108e-07 1270 1159.90909090909 990 2.9277496145262e-08 203 2.54594763325236 2.35139770146201 1 14.3557939826094 1268 1907 761 967 1705 1128 203 2648 524 990 658 768 M14694 GO_COCHLEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_DEVELOPMENT.html The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. 21/75 Gene Ontology BP GO:0090102 1.22119791452565e-07 3.8440826556899e-07 990 1280.27272727273 990 1.11017998392103e-08 552 1.95466159363094 2.2369981017112 1 11.6399578560456 990 552 822 610 1396 2116 989 2532 1647 811 1618 769 M13048 GO_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEARNING.html Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. 65/227 Gene Ontology BP GO:0007612 6.80816611684833e-09 5.53300965206403e-08 995 1106.54545454545 991 6.18924194356093e-10 338 1.67412723885643 1.76452701642044 1 11.2776088737774 991 786 1439 821 338 1557 832 2203 603 1117 1485 770 M16150 GO_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION.html Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. 42/127 Gene Ontology BP GO:0061337 5.92680622028091e-07 1.40829893965017e-06 810 1263.81818181818 992 5.38800710633162e-08 339 2.18076987044205 2.26931844032368 1 11.8449087777896 806 2087 587 339 1880 1257 992 3340 830 409 1375 771 M10794 GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. 22/44 Gene Ontology BP GO:0051145 5.4632112653174e-06 1.0010138084005e-05 605 1203.54545454545 995 4.9665680291237e-07 539 2.17683994632617 2.22951750390248 1 10.1024663071461 603 1740 751 995 2455 678 539 1606 971 1197 1704 772 M11086 GO_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. 121/310 Gene Ontology BP GO:0007009 6.51545331693519e-08 2.35235223565553e-07 880 937.636363636364 995 5.92313955444989e-09 70 1.92889624754279 2.08047261684629 1 11.8684255407029 880 70 396 1095 1185 1247 1144 2151 772 379 995 773 M11566 GO_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_MOVEMENT.html Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. 60/158 Gene Ontology BP GO:0030048 3.44135120797123e-11 7.19738453090559e-10 995 1337.81818181818 995 3.12850109820461e-12 206 2.64867027649917 2.91266940087369 1 22.4790243268581 995 1942 206 705 816 2157 1627 2787 852 241 2388 774 M10048 GO_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. 49/162 Gene Ontology BP GO:0021510 4.94874152621215e-07 1.20298465477503e-06 745 974.363636363636 996 4.49885694490569e-08 492 1.99166127228395 2.25186766803647 1 10.9442810924172 741 1221 892 517 1836 1233 492 595 1139 1056 996 775 M16953 GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 134/317 Gene Ontology BP GO:0000302 1.15392648461589e-08 7.42061034358941e-08 1000 1080.09090909091 996 1.04902408242579e-09 360 1.94370470714217 2.26489342470951 1 12.8635895060328 996 1116 360 863 541 2156 1335 527 1764 656 1567 776 M15576 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. 17/37 Gene Ontology BP GO:0050961 3.22052410453439e-07 8.42416530555108e-07 1270 1163.90909090909 997 2.9277496145262e-08 204 2.54594763325236 2.35139770146201 1 14.3557939826094 1269 1908 762 968 1706 1129 204 2676 525 997 659 777 M13011 GO_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a cell population. 391/1073 Gene Ontology BP GO:0008283 1.94373623393581e-10 3.74471673616762e-09 945 978.181818181818 998 1.76703294009776e-11 141 1.84101981240213 2.08971368003978 1 14.400547352856 943 998 222 608 141 2324 1244 1011 1477 352 1440 778 M11177 GO_REGULATION_OF_BODY_FLUID_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BODY_FLUID_LEVELS.html Any process that modulates the levels of body fluids. 309/777 Gene Ontology BP GO:0050878 2.84647863101999e-22 4.13006258869556e-20 445 847.454545454545 1002 2.5877078463818e-23 31 2.05092164283201 2.28267519636075 1 36.9030771113389 443 749 31 902 1002 1068 1087 1076 1541 124 1299 779 M13178 GO_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that modulates the frequency, rate or extent of response to wounding. 236/603 Gene Ontology BP GO:1903034 2.08657699658319e-14 7.33937651146646e-13 605 984.363636363636 1002 1.896888178712e-15 122 1.90611653667195 2.12426615393663 1 21.4701350691439 604 1002 122 838 142 1811 1260 1376 1707 166 1800 780 M13558 GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 732/2007 Gene Ontology BP GO:1901700 7.49298035565895e-13 2.0344975316564e-11 775 1200.72727272727 1003 7.49298035566146e-14 8 1.90457137640094 2.17332525611563 1 18.9019569983126 772 8 4096 308 392 2169 1276 1003 1846 27 1311 781 M15772 GO_NEPHRON_TUBULE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_TUBULE_FORMATION.html The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. 9/25 Gene Ontology BP GO:0072079 1.15013866637727e-08 7.40651016364725e-08 1340 1309.18181818182 1003 1.15013867232995e-09 71 2.31324984095867 2.83572896477985 1 15.3110417671682 1340 865 4455 432 577 1958 1003 1589 71 752 1359 782 M14737 GO_RESPONSE_TO_PARATHYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PARATHYROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. 11/27 Gene Ontology BP GO:0071107 4.44950791821082e-07 1.10417238184141e-06 620 1131.27272727273 1005 4.04500801647786e-08 111 2.50880217602231 2.12169752120136 1 13.8726830777391 617 1167 859 719 1796 776 1366 2683 111 1005 1345 783 M11941 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. 274/657 Gene Ontology BP GO:1902532 1.78873178237833e-09 2.66700591645339e-08 1010 1116.09090909091 1008 1.62611980348424e-10 34 1.36636306666039 1.57847185982939 1 9.60636697490031 1008 754 2077 1142 34 931 1128 331 2326 2065 481 784 M14490 GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 14/45 Gene Ontology BP GO:0035412 4.06436685538098e-08 1.69549463697519e-07 660 863.272727272727 1008 3.69487902769792e-09 48 1.70546366802739 1.6269703073618 1 10.718781223157 659 1164 1334 1032 1008 506 290 540 1892 1023 48 785 M16730 GO_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. 188/476 Gene Ontology BP GO:0048589 9.16216036171478e-09 6.53424683264709e-08 450 942.272727272727 1008 8.32923672715607e-10 428 1.81003908731109 1.87659415740078 1 12.0718002760961 738 1008 611 448 446 1441 1227 1280 1609 428 1129 786 M12371 GO_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BEHAVIOR.html Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 23/91 Gene Ontology BP GO:0050795 1.72018390795109e-06 3.56554191277541e-06 1210 1160.54545454545 1009 1.56380477542493e-07 386 2.03255893990218 2.42943417790232 1 10.2787279693406 1208 386 696 876 2165 1780 1200 1009 846 575 2025 787 M15943 GO_REGULATION_OF_CELL_SHAPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SHAPE.html Any process that modulates the surface configuration of a cell. 82/204 Gene Ontology BP GO:0008360 4.08747253816125e-08 1.70207488741549e-07 785 1024.09090909091 1009 3.71588419464012e-09 390 1.82640141407794 2.11377889210058 1 11.4760188322194 783 1027 909 572 1009 1886 1430 390 1157 754 1348 788 M16273 GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 35/95 Gene Ontology BP GO:0014068 6.29784206237318e-06 1.13910715604202e-05 475 1178.90909090909 1009 5.72532735545231e-07 407 1.95051895809796 2.42877627515985 1 8.95051805867599 474 1532 798 1536 2481 661 1009 578 1796 1696 407 789 M14645 GO_LEUKOCYTE_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CELL_CELL_ADHESION.html The attachment of a leukocyte to another cell via adhesion molecules. 152/415 Gene Ontology BP GO:0007159 2.73469703717666e-08 1.28555726231123e-07 1400 1194.72727272727 1011 2.48608824651832e-09 91 1.98288741365978 2.39178424234184 1 12.6836333505849 1397 1011 404 91 870 3289 1887 656 1348 623 1566 790 M16126 GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. 33/105 Gene Ontology BP GO:2000177 1.70293558927022e-07 4.97592111609153e-07 1075 941.363636363636 1011 1.54812338280722e-08 325 1.75001770197905 2.24273311185717 1 10.2392370962577 1073 533 1011 400 1509 1513 923 325 711 1242 1115 791 M10525 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 69/187 Gene Ontology BP GO:0014066 1.53409965955612e-08 8.81007670041974e-08 580 1115.54545454545 1013 1.39463606386697e-09 577 1.70774679264031 1.9652344143106 1 11.1838383463022 577 783 910 1681 652 957 1013 1037 2101 1359 1201 792 M10790 GO_INDOLALKYLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLALKYLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. 6/18 Gene Ontology BP GO:0006586 1.09169692411933e-06 2.40111265688587e-06 510 1313.27272727273 1013 1.09169746043068e-07 77 1.69770421661495 -1.69770421661495 -1 8.85595894429084 509 876 3636 1799 2861 205 77 1013 1881 1073 516 793 M11393 GO_NEURAL_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. 102/237 Gene Ontology BP GO:0021915 3.277343870578e-09 3.84357595519315e-08 770 1098.18181818182 1013 2.97940352314569e-10 119 1.56178267063884 1.67888316168052 1 10.7501959958925 955 770 1474 650 119 1767 1330 1443 1790 769 1013 794 M14680 GO_RESPONSE_TO_YEAST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_YEAST.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. 8/22 Gene Ontology BP GO:0001878 3.72167963879182e-07 9.52052813383495e-07 1295 1526.54545454545 1014 3.72168026208243e-08 233 2.5543517452848 1.87754366453278 1 14.2771957147385 1293 233 4272 1101 1773 820 823 3819 996 648 1014 795 M15858 GO_TRYPTOPHAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRYPTOPHAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. 6/13 Gene Ontology BP GO:0006568 1.09169692411933e-06 2.40111265688587e-06 510 1390.72727272727 1014 1.09169746043068e-07 78 1.69770421661495 -1.69770421661495 -1 8.85595894429084 510 877 4467 1800 2862 206 78 1014 1882 1085 517 796 M16011 GO_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). 117/281 Gene Ontology BP GO:0046777 3.12217247551241e-08 1.40371965280257e-07 735 1423.81818181818 1014 2.83833865438303e-09 734 1.5719519479378 1.79954152998887 1 9.99934062013091 734 2168 2120 1716 919 1014 890 872 1988 2429 812 797 M10370 GO_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_BINDING.html Any process that modulates the frequency, rate or extent of protein binding. 119/277 Gene Ontology BP GO:0043393 4.90734169167261e-09 4.70279390287928e-08 695 1137.36363636364 1016 4.46121972965361e-10 226 1.51186572299957 1.89222823918955 1 10.2836365560183 695 1016 1169 878 226 1856 1383 581 1903 1921 883 798 M14248 GO_RESPONSE_TO_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TEMPERATURE_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. 100/246 Gene Ontology BP GO:0009266 2.55015909623067e-08 1.21832965878237e-07 900 1250.54545454545 1016 2.31832647799198e-09 438 2.01008341207642 2.04217112202847 1 12.901118451651 900 2083 570 1563 853 1291 876 2465 1701 438 1016 799 M14727 GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. 59/151 Gene Ontology BP GO:1904064 1.46147987898307e-09 2.28473100273346e-08 1490 1160.63636363636 1016 1.3286180726854e-10 22 1.79675714820703 2.07958709636314 1 12.7443617400315 1487 508 778 639 22 2665 1857 967 1458 1016 1370 800 M14165 GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION.html Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. 24/46 Gene Ontology BP GO:0070570 2.55054152129327e-08 1.21832965878237e-07 635 1098 1017 2.31867413714785e-09 634 1.71451226734248 2.09996077863641 1 11.0040835393416 634 1386 992 739 854 1017 1044 1588 1218 1750 856 801 M16735 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL.html The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. 18/73 Gene Ontology BP GO:0003044 7.56816706507816e-07 1.7386937003047e-06 900 1172.72727272727 1017 6.88015424416942e-08 435 2.9032881550495 2.74840643714412 1 15.5226170003679 899 2095 1017 1215 1953 827 866 435 1118 1939 536 802 M11043 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of glia cell differentiation. 16/45 Gene Ontology BP GO:0045687 8.48590174046478e-06 1.49186072627709e-05 655 1088.18181818182 1018 7.71448588427261e-07 166 2.72293488311488 3.03209139281869 1 12.1988294531097 819 1163 1194 654 2549 1018 1057 655 166 2192 503 803 M10170 GO_HINDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). 79/247 Gene Ontology BP GO:0030902 7.39218313594916e-08 2.5901401979669e-07 940 1158.54545454545 1020 6.72016671302971e-09 324 1.90380582665279 2.18473982026451 1 11.6401381632714 937 2458 941 811 1236 1597 1150 324 1020 679 1591 804 M10649 GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. 52/130 Gene Ontology BP GO:2000106 2.14023649319655e-07 5.97901205650516e-07 900 1387.09090909091 1020 1.94566972855111e-08 664 2.19757000035223 2.40419633382166 1 12.6951405939658 898 3110 911 2178 1590 1020 825 991 1817 1254 664 805 M10760 GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 822/2178 Gene Ontology BP GO:0010647 6.77707101557828e-09 5.53004230673637e-08 980 1354.09090909091 1020 6.77707103624619e-10 336 1.71414526615848 2.01167065984593 1 11.5475574528265 976 993 3629 1020 365 2198 1357 1056 2045 336 920 806 M14988 GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 18/66 Gene Ontology BP GO:0071391 5.33854869197869e-08 2.06385358674913e-07 750 1140.18181818182 1020 4.853226201386e-09 33 2.35915319578553 2.30681024662245 1 14.6402182895207 747 2183 838 1595 1857 283 469 1020 2039 1478 33 807 M13157 GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). 14/36 Gene Ontology BP GO:0001941 7.04752937876e-08 2.49783808439562e-07 3445 1666.18181818182 1021 6.40684509502015e-09 304 1.68360877438185 -1.08551640585491 -1 10.3184507504342 3443 408 824 752 1217 4462 3386 304 361 1021 2150 808 M16107 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 559/1448 Gene Ontology BP GO:0051241 3.39676968678617e-10 6.23367654377398e-09 555 1228.27272727273 1022 3.39676968730537e-11 52 1.91478479402892 2.12300464930852 1 14.5841535291454 552 603 4509 672 696 1448 1103 1022 1673 52 1181 809 M14239 GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. 94/300 Gene Ontology BP GO:0051480 1.90720124720156e-08 1.0108602044243e-07 630 1168.72727272727 1023 1.73381933066842e-09 312 2.03058958880537 2.09315679943167 1 13.1855481074887 626 1023 312 601 1859 1173 1011 2424 2020 513 1294 810 M15931 GO_MELANOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. 11/30 Gene Ontology BP GO:0030318 4.36501709989048e-08 1.79403662030111e-07 2005 1084.36363636364 1023 3.96819744226975e-09 62 2.51238143440392 2.72359320234302 1 15.7330132763428 2004 224 740 430 1023 2179 1491 1121 62 1006 1648 811 M10247 GO_LENS_FIBER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. 23/49 Gene Ontology BP GO:0070306 1.18678249663556e-07 3.76124991937126e-07 1145 984.545454545455 1024 1.07889323696013e-08 223 2.10043589056983 2.24708533382564 1 12.5264855816107 1144 1385 860 398 1386 1024 640 1562 223 1276 932 812 M15627 GO_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 14/45 Gene Ontology BP GO:0050704 2.65007086684006e-07 7.18763219950866e-07 650 1394.81818181818 1024 2.40915562369248e-08 106 1.67895052092555 1.66766453122266 1 9.57451589692278 650 2437 1725 2864 1645 234 106 765 3432 1024 461 813 M10711 GO_NITROGEN_CYCLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_CYCLE_METABOLIC_PROCESS.html A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. 7/30 Gene Ontology BP GO:0071941 9.44498927325651e-09 6.64805736677504e-08 1265 1217.81818181818 1025 9.44498931340002e-10 284 2.2037268966318 -2.60046683476137 -1 14.6821049827494 1264 584 3623 1124 504 1025 1648 444 284 1960 936 814 M10536 GO_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CHEMOTAXIS.html The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). 82/236 Gene Ontology BP GO:0060326 1.90686908799321e-08 1.0108602044243e-07 450 1076.81818181818 1026 1.73351736774652e-09 319 2.20222734507087 2.18765146083882 1 14.3000706775689 448 1514 319 1026 728 1367 984 1668 1779 491 1521 815 M16895 GO_RECEPTOR_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CLUSTERING.html The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. 23/64 Gene Ontology BP GO:0043113 2.80655247551333e-07 7.52356994446212e-07 950 1135.63636363636 1027 2.5514116668608e-08 309 1.65851714248878 2.04555679229675 1 9.42744945258864 1027 947 950 913 1665 1559 1445 309 939 1629 1109 816 M11635 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 22/31 Gene Ontology BP GO:1902230 1.02522462887946e-08 6.93894745173081e-08 1235 1088.90909090909 1029 9.32022394233749e-10 338 1.27724428473672 1.41362914806469 1 8.48745825009078 1231 681 1821 1029 497 1080 757 923 1680 1941 338 817 M13699 GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 5/17 Gene Ontology BP GO:0010759 7.9281331357708e-06 1.4065847210311e-05 845 1517.90909090909 1030 7.92816142079557e-07 551 2.55673432749838 2.55673432749838 1 11.5149135004624 845 2296 4119 1025 2670 1145 767 551 744 1505 1030 818 M13980 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 81/177 Gene Ontology BP GO:1903844 1.53507474706861e-08 8.81007670041974e-08 725 1114.36363636364 1030 1.39552250707252e-09 497 1.96420585778193 2.09894702045816 1 12.8633594507391 1234 497 645 722 654 2351 1730 1030 1279 723 1393 819 M11316 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. 9/16 Gene Ontology BP GO:0055022 4.40070678977461e-05 6.81309824105485e-05 1020 1549.72727272727 1031 4.40079394019472e-06 105 3.45797805406843 3.45797805406843 1 13.3745428639841 1019 2286 3729 819 3196 1342 562 1031 105 2336 622 820 M15548 GO_CELL_VOLUME_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_VOLUME_HOMEOSTASIS.html Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. 19/45 Gene Ontology BP GO:0006884 2.5567544408362e-07 6.98573179108295e-07 1035 1290 1032 2.32432248906573e-08 288 1.79154753846643 1.83277253695394 1 10.2371986662854 1032 400 891 1722 1633 870 455 2541 2297 2061 288 821 M16467 GO_DERMATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. 7/14 Gene Ontology BP GO:0030205 1.35759490946159e-05 2.29796323901939e-05 415 1424.36363636364 1032 1.35760320332063e-06 402 2.27739700490326 2.27739700490326 1 9.80618611219111 413 1634 4569 1797 2680 547 402 1032 412 1321 861 822 M14231 GO_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/57 Gene Ontology BP GO:0032371 8.30377495547693e-07 1.88408287630992e-06 1150 943.909090909091 1033 7.54888917244657e-08 214 2.20215549425299 2.6151366835125 1 11.7026716735667 874 1150 1137 294 1976 1033 1148 318 409 1830 214 823 M13900 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that activates, maintains or increases the rate of developmental growth. 97/260 Gene Ontology BP GO:0048639 4.64056239404439e-09 4.5728211272053e-08 1200 994.363636363636 1034 4.21869309439359e-10 204 2.12319549107823 2.57482929230449 1 14.4658607279985 1200 1121 444 479 204 2174 1880 1034 1097 447 858 824 M15298 GO_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/57 Gene Ontology BP GO:0032374 8.30377495547693e-07 1.88408287630992e-06 875 947.818181818182 1034 7.54888917244657e-08 215 2.20215549425299 2.6151366835125 1 11.7026716735667 875 1151 1138 295 1977 1034 1149 350 410 1832 215 825 M13364 GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. 17/41 Gene Ontology BP GO:0048485 1.6458038793531e-07 4.87027878383457e-07 740 975.363636363636 1036 1.49618545679499e-08 319 2.13279302018176 2.76072096911169 1 12.4972809764163 1080 1240 772 1036 1495 1178 1171 963 319 738 737 826 M16411 GO_NEGATIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_GROWTH.html Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 9/16 Gene Ontology BP GO:0061117 4.40070678977461e-05 6.81309824105485e-05 1020 1629.72727272727 1036 4.40079394019472e-06 106 3.45797805406843 3.45797805406843 1 13.3745428639841 1020 2287 4560 820 3197 1343 563 1036 106 2372 623 827 M15455 GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. 27/69 Gene Ontology BP GO:0034637 5.37490897768464e-08 2.07445572596756e-07 1040 1167.63636363636 1037 4.88628100818293e-09 873 1.87760994524453 2.10490147771425 1 11.6480224807795 1342 944 873 1018 1103 1547 1037 1149 1793 1036 1002 828 M11822 GO_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_PROLIFERATION.html The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 35/97 Gene Ontology BP GO:0072089 5.39562413702193e-08 2.07899442889567e-07 810 1092.81818181818 1038 4.9051129721388e-09 564 2.12300825695316 2.22058517110331 1 13.1685156143908 808 1787 1029 1058 1105 1726 1555 779 564 572 1038 829 M11855 GO_REGULATION_OF_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENERGY_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of energy homeostasis. 12/44 Gene Ontology BP GO:2000505 7.16662905453128e-08 2.53231801371299e-07 1040 1451.72727272727 1038 6.51511753453492e-09 94 2.91854969744818 2.91854969744818 1 17.8709893432856 1038 2526 1521 1770 3356 722 230 94 936 3395 381 830 M10302 GO_MAMMARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_MORPHOGENESIS.html The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 40/77 Gene Ontology BP GO:0060443 2.18628094991115e-08 1.09641784421907e-07 4090 2119.36363636364 1041 1.9875281560342e-09 440 2.09841205931378 -2.0678944527147 -1 13.5572198987836 4090 1041 508 647 790 3847 3388 3963 440 531 4068 831 M12859 GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT.html The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. 19/54 Gene Ontology BP GO:0048566 1.54917654628734e-08 8.82555423854249e-08 1105 1081.54545454545 1041 1.40834232472381e-09 660 1.84653344337708 2.22731607292312 1 12.0914296317421 1103 1065 915 1735 660 1274 842 1041 1684 690 888 832 M15711 GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. 9/18 Gene Ontology BP GO:0060055 5.78916005945698e-07 1.38195733450174e-06 515 1294.81818181818 1041 5.78916156760437e-08 59 1.93921008247812 1.93921008247812 1 10.5476315494933 514 1757 4445 1659 2317 168 59 467 1041 1667 149 833 M11551 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. 22/70 Gene Ontology BP GO:0003333 4.7988140303221e-08 1.90597891726138e-07 1030 1012.45454545455 1042 4.36255830454328e-09 376 2.25034897248327 2.4620628104195 1 14.037205194285 1026 1394 1042 1304 1068 1808 1390 446 376 884 399 834 M14879 GO_CELLULAR_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 80/199 Gene Ontology BP GO:0097306 5.68712635839029e-09 5.04881982447536e-08 695 1142.54545454545 1043 5.17011488462895e-10 271 2.2754109171803 2.35439798201687 1 15.4121071409165 693 2503 373 1214 271 1416 801 798 2154 1302 1043 835 M15775 GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 73/203 Gene Ontology BP GO:0043271 4.59027880820481e-08 1.85488812066971e-07 965 1181.90909090909 1045 4.1729808218005e-09 452 1.85123345158583 2.07160927352617 1 11.567884240988 964 915 590 1022 1045 1687 1169 2076 1539 452 1542 836 M14185 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 60/165 Gene Ontology BP GO:0002065 3.35507447717557e-08 1.47655078649537e-07 1680 1269.27272727273 1047 3.0500677530378e-09 216 2.45883210350176 2.63137853745896 1 15.5907319413739 1677 1520 535 216 947 2990 1900 810 358 1047 1962 837 M10433 GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of endocytosis. 73/190 Gene Ontology BP GO:0045807 8.75047286104142e-08 2.95264865507379e-07 800 1056.18181818182 1051 7.95497564462764e-09 451 1.89909528587772 1.99985705313668 1 11.511051233663 800 914 488 877 1291 1089 1209 1051 1933 451 1515 838 M10999 GO_PEROXISOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 25/36 Gene Ontology BP GO:0007031 1.82593200911986e-07 5.27226512334795e-07 560 1684.09090909091 1053 1.65993832787872e-08 139 0.800857922509474 -0.800151993428624 -1 4.66708920265269 557 1053 3218 2397 1530 139 414 823 3742 4016 636 839 M14639 GO_HEART_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_DEVELOPMENT.html The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. 21/47 Gene Ontology BP GO:0003170 1.3694016203673e-06 2.9273166313837e-06 940 1280.90909090909 1054 1.24491133887211e-07 624 1.93778113099686 2.08655658381476 1 9.95350750800801 936 2002 1054 1490 2105 819 768 897 1564 1831 624 840 M15753 GO_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. 218/611 Gene Ontology BP GO:0048732 1.78412786295229e-12 4.52661511895491e-11 170 1010 1054 1.62193442086703e-13 169 1.99582947391848 2.23269881680367 1 19.1641952978496 1276 282 169 279 385 2591 1807 1549 1054 169 1549 841 M12339 GO_REGULATION_OF_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_AGGREGATION.html Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. 10/26 Gene Ontology BP GO:0090330 4.81301326571653e-07 1.17738780783571e-06 1065 985.636363636364 1056 4.37546756243254e-08 547 2.28609460554242 2.621376485853 1 12.5820289008876 1061 1095 773 1056 1828 1070 1190 641 547 864 717 842 M15924 GO_MODULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 138/448 Gene Ontology BP GO:0050804 1.42795775404324e-08 8.4674429783177e-08 810 962.454545454545 1056 1.29814342119246e-09 439 1.89651550253231 2.03593325522442 1 12.4503911716478 810 1277 544 439 622 1272 1056 1171 1105 726 1565 843 M11070 GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. 16/46 Gene Ontology BP GO:0045747 1.78676850649573e-07 5.18174027211721e-07 1450 1112.09090909091 1058 1.62433513782843e-08 194 2.23282204211191 2.68544425389263 1 13.0276103359587 1448 1075 1058 478 1523 2183 967 194 252 2193 862 844 M12310 GO_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 929/2794 Gene Ontology BP GO:0009605 3.70559537360574e-13 1.04273207997887e-11 995 1314.54545454545 1058 3.70559537360635e-14 26 1.87775537143393 2.13374318092126 1 19.1417993247422 994 250 3889 704 469 2580 1461 1224 1805 26 1058 845 M14377 GO_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_FORMATION.html Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. 80/190 Gene Ontology BP GO:0035148 8.17989103946899e-09 6.1355790139345e-08 865 1197.54545454545 1059 7.43626460898444e-10 319 1.54386740176171 1.50098222213512 1 10.3357869168453 861 319 1356 808 404 1563 1059 2707 1467 788 1841 846 M16748 GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structure of the retina is generated and organized. 23/80 Gene Ontology BP GO:0060042 1.97422337807598e-08 1.02761425385726e-07 745 1008.09090909091 1059 1.79474854162922e-09 539 1.81017747743628 2.16601041275842 1 11.7423155172694 1286 1059 1118 1268 745 1669 1091 539 759 742 813 847 M10366 GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. 5/17 Gene Ontology BP GO:0031953 6.28046834723944e-08 2.30162001994041e-07 1720 1259.72727272727 1060 6.28046852473872e-09 91 2.15602057613179 2.57467901808663 1 13.2848631457004 1720 444 3574 848 1568 1949 1060 91 160 1491 952 848 M10419 GO_ORGAN_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_REGENERATION.html The regrowth of a lost or destroyed organ. 58/128 Gene Ontology BP GO:0031100 6.39208224870386e-08 2.32583599152169e-07 400 924 1060 5.81098403129571e-09 36 1.95998667871129 2.13408339656442 1 12.0686810565523 399 1667 1076 1060 1229 665 531 400 1491 1610 36 849 M15939 GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS.html The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. 8/15 Gene Ontology BP GO:0003222 9.45322475015062e-07 2.11830707118481e-06 1060 1459 1060 9.45322877150863e-08 147 4.85309828577535 4.85309828577535 1 25.5610332603 1060 1631 4482 815 2319 1316 839 319 182 2939 147 850 M10386 GO_COGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COGNITION.html The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. 123/419 Gene Ontology BP GO:0050890 9.47937149852465e-09 6.64805736677504e-08 620 980.545454545455 1061 8.61761049033585e-10 460 1.74662263828449 1.85308197487098 1 11.6366945861308 618 1118 1028 767 460 1138 1167 1360 1162 1061 907 851 M13280 GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 312/759 Gene Ontology BP GO:0010563 4.32180589463764e-09 4.40047034403565e-08 985 1091.27272727273 1061 3.92891445738877e-10 189 1.61188015162753 1.89729973764495 1 11.0071066443515 985 1429 1061 1374 189 1220 886 732 1986 1307 835 852 M13026 GO_RESPONSE_TO_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 482/1432 Gene Ontology BP GO:0009725 4.60389913924693e-26 1.06879518517618e-23 20 964.545454545455 1062 4.18536285386084e-27 18 2.01922279831226 2.17543212634736 1 43.0561583720062 1062 18 20 254 558 2303 1386 1979 1651 49 1330 853 M14126 GO_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_METABOLIC_PROCESS.html The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 102/392 Gene Ontology BP GO:0008202 6.6583837065916e-09 5.50177850965416e-08 3465 1969.09090909091 1062 6.05307611522129e-10 309 1.90845638454423 1.95049826582366 1 12.8605013243315 3463 309 489 667 327 3030 3528 3947 1062 608 4230 854 M15999 GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 312/759 Gene Ontology BP GO:0045936 4.32180589463764e-09 4.40047034403565e-08 990 1072.72727272727 1062 3.92891445738877e-10 190 1.61188015162753 1.89729973764495 1 11.0071066443515 986 1430 1062 1375 190 1221 887 518 1987 1308 836 855 M12028 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. 38/82 Gene Ontology BP GO:1904377 1.85220472821407e-08 9.93431355762042e-08 2820 2030.18181818182 1063 1.6838224943709e-09 394 1.81742337111784 -1.69536794893207 -1 11.8141048227827 2820 665 1063 394 715 3549 2628 4499 861 1048 4090 856 M14816 GO_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_DISASSEMBLY.html A process that results in the breakdown of the extracellular matrix. 44/149 Gene Ontology BP GO:0022617 4.75472281972642e-09 4.60880543882876e-08 1555 1318 1063 4.32247530000229e-10 261 2.31696576585708 2.78995739006645 1 15.7787445046788 1554 657 287 899 369 3325 2554 1063 1068 261 2461 857 M14254 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. 38/82 Gene Ontology BP GO:1903078 1.85220472821407e-08 9.93431355762042e-08 2825 2031.63636363636 1064 1.6838224943709e-09 395 1.81742337111784 -1.69536794893207 -1 11.8141048227827 2821 666 1064 395 716 3550 2629 4504 862 1050 4091 858 M14322 GO_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULOGENESIS.html The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. 48/94 Gene Ontology BP GO:0001570 5.1794320770088e-08 2.02060926287663e-07 195 1011.81818181818 1064 4.70857472631591e-09 195 2.12422888459285 1.99215777091738 1 13.2004804141348 195 1893 600 1228 1091 637 400 1745 1449 828 1064 859 M16371 GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 833/2142 Gene Ontology BP GO:0051174 2.57293179595633e-09 3.41694701612955e-08 840 1361.63636363636 1066 2.57293179893532e-10 87 1.65678708779405 1.93658245530974 1 11.4827223557434 839 1107 4554 1133 87 1914 1066 837 2204 268 969 860 M16536 GO_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 55/235 Gene Ontology BP GO:0042445 3.08368217334457e-08 1.39444289183127e-07 2455 1895.90909090909 1067 2.80334746960703e-09 125 2.05404918779025 2.16398075521085 1 13.0714991345137 2454 125 747 941 913 3902 2187 4273 1067 986 3260 861 M14703 GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. 10/18 Gene Ontology BP GO:0045653 6.42602066507301e-05 9.69331187392267e-05 605 1332.09090909091 1068 5.8420076105221e-06 397 1.83739956324294 -1.83739956324294 -1 6.8454029099217 601 1482 1220 1754 3014 397 1065 1068 2261 867 924 862 M13080 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. 4/18 Gene Ontology BP GO:2000258 1.26574663847315e-05 2.15664647428654e-05 795 1679.36363636364 1069 1.26575384804643e-06 186 1.53578650836581 1.53578650836581 1 6.652199796166 793 1935 4008 2388 2980 451 186 831 1069 3116 716 863 M13561 GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 11/31 Gene Ontology BP GO:2000463 2.63454521129347e-06 5.16562221960961e-06 1330 1144.54545454545 1070 2.39504396929162e-07 533 1.73878954905928 -1.84172386522117 -1 8.5332680710941 1330 709 1428 1070 2288 864 1576 590 752 1450 533 864 M16241 GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX.html The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. 7/13 Gene Ontology BP GO:0016558 5.73588257781549e-05 8.72312571529555e-05 1075 2039.90909090909 1071 5.73603063476427e-06 394 0.700549143850597 -0.700549143850597 -1 2.63974420832406 1071 984 4533 2726 3464 394 507 1066 2252 4609 833 865 M11796 GO_MEMBRANE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a membrane. 12/40 Gene Ontology BP GO:0071709 7.60140599875902e-07 1.74460346278982e-06 1075 964.727272727273 1072 6.91037147744212e-08 77 1.79436177167046 1.77480266826769 1 9.59121607574843 1188 214 1223 713 1954 1072 1073 851 77 774 1473 866 M12292 GO_KIDNEY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. 15/30 Gene Ontology BP GO:0061440 2.09488170486776e-07 5.86642687316104e-07 415 1106.45454545455 1072 1.90443809486035e-08 365 2.74086312698317 3.12106240975162 1 15.8546949044328 415 1072 365 974 2589 1076 1585 1612 654 589 1240 867 M14710 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 614/1522 Gene Ontology BP GO:0031401 9.10599812795936e-09 6.52456007841286e-08 1075 1477.45454545455 1072 9.10599816527301e-10 400 1.61129693552102 1.89123566152172 1 10.747281199402 1072 453 4277 861 481 2696 1424 1398 2250 400 940 868 M14598 GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. 15/30 Gene Ontology BP GO:0061437 2.09488170486776e-07 5.86642687316104e-07 420 1107.36363636364 1073 1.90443809486035e-08 366 2.74086312698317 3.12106240975162 1 15.8546949044328 416 1073 366 975 2590 1077 1586 1611 655 591 1241 869 M16354 GO_REGULATION_OF_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of organ morphogenesis. 130/309 Gene Ontology BP GO:2000027 2.31201705294659e-08 1.14564516294888e-07 1365 1286.45454545455 1075 2.10183370658542e-09 338 1.77727486095432 2.01738807921721 1 11.4509795882152 1363 486 716 338 813 3591 1848 1655 1075 571 1695 870 M12312 GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of adenylate cyclase activity. 21/86 Gene Ontology BP GO:0045761 5.7764010966071e-08 2.18004113576288e-07 805 1213.63636363636 1077 5.25127386206766e-09 378 2.07783896943865 1.99618630001297 1 12.8485866233429 803 1464 1077 2075 1134 763 378 2305 1648 1066 637 871 M16092 GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 20/47 Gene Ontology BP GO:0009069 8.82511949707746e-07 1.99198005954937e-06 1080 1278.27272727273 1079 8.02283912473067e-08 278 1.25443749555414 -1.34217173101874 -1 6.63815648732109 1079 394 2138 2627 1990 278 388 431 2067 2172 497 872 M16742 GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. 9/18 Gene Ontology BP GO:2001275 4.51509161821807e-06 8.3988663394978e-06 915 1560 1085 4.51510079196784e-07 199 1.59151438608637 1.75528429942147 1 7.49863875287628 915 1182 4614 2125 2434 555 199 855 1085 2374 822 873 M13394 GO_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/158 Gene Ontology BP GO:0006865 2.49156644114842e-08 1.20220918930377e-07 2400 1652.54545454545 1086 2.2650604266965e-09 293 2.0044760956472 2.34133883016302 1 12.875893140724 2396 651 546 1086 844 4489 2808 2464 873 293 1728 874 M12163 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 765/2167 Gene Ontology BP GO:0009719 7.18587870870588e-14 2.26966223432118e-12 880 1105.27272727273 1088 7.18587870870608e-15 5 1.9421763791384 2.13568057445635 1 20.992368853525 877 5 3861 117 326 1765 1204 1329 1565 21 1088 875 M10858 GO_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. 467/1187 Gene Ontology BP GO:0007010 8.25597781071069e-09 6.16777792481972e-08 1195 1161.45454545455 1090 7.50543440153912e-10 407 1.75491206026214 2.04959209583124 1 11.7449724931222 1191 2253 457 1090 407 2279 1236 738 1840 584 701 876 M10937 GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that activates or increases the activity of a transporter. 42/118 Gene Ontology BP GO:0032411 2.36997103442047e-08 1.16228070309752e-07 1725 1414.72727272727 1094 2.15451914541019e-09 526 1.78966374691898 2.08090640745168 1 11.5204001088944 1724 526 1094 761 825 3196 2006 1133 1055 1090 2152 877 M15665 GO_ASPARTATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. 5/12 Gene Ontology BP GO:0006531 8.3800349876376e-06 1.47604334019732e-05 1095 1454.90909090909 1095 8.38006658904921e-07 405 1.62155811941115 -1.62155811941115 -1 7.2715965833291 1095 1426 4435 979 2578 405 664 911 1574 1513 424 878 M15682 GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS.html The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. 63/167 Gene Ontology BP GO:0060560 8.69220742705675e-09 6.33562309008234e-08 1645 1168.54545454545 1095 7.90200678309061e-10 427 1.76349222880236 1.78696913528187 1 11.7833082182576 1232 923 733 856 427 1642 1095 1640 1644 534 2128 879 M10701 GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that modulates the activity of a monooxygenase. 38/91 Gene Ontology BP GO:0032768 5.20679020616871e-08 2.02141462392973e-07 1595 1214.45454545455 1096 4.73344575399909e-09 530 1.81395328803157 2.28614738978163 1 11.2720601551826 1591 530 779 1041 1096 2197 1477 956 1568 839 1285 880 M10826 GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 116/257 Gene Ontology BP GO:0046395 3.67603920051255e-08 1.57743530572826e-07 1045 1175.36363636364 1096 3.34185387448771e-09 306 1.54264162381389 -1.44679018365813 -1 9.74033511842432 1044 306 1128 1649 976 418 1799 856 1854 1803 1096 881 M10295 GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 10/24 Gene Ontology BP GO:0009084 2.56902902801595e-07 7.01234672373783e-07 925 1337.18181818182 1097 2.33548120728356e-08 253 1.64463421699893 1.81289437539232 1 9.39519043797781 925 1097 1959 1836 1635 1555 592 619 253 3186 1052 882 M13128 GO_ORGANIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. 116/257 Gene Ontology BP GO:0016054 3.67603920051255e-08 1.57743530572826e-07 1045 1182.09090909091 1097 3.34185387448771e-09 307 1.54264162381389 -1.44679018365813 -1 9.74033511842432 1045 307 1129 1650 977 419 1800 920 1855 1804 1097 883 M10763 GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 26/78 Gene Ontology BP GO:0090218 1.17709331027e-07 3.73311560685077e-07 610 1170.09090909091 1098 1.07008488477227e-08 510 1.9912921773328 2.17081193917618 1 11.8816064651495 607 2179 1098 1156 1384 871 510 902 2069 942 1153 884 M13923 GO_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. 13/54 Gene Ontology BP GO:0055078 3.16190587203485e-06 6.09158878168374e-06 885 1235.09090909091 1098 2.87446401493617e-07 409 1.98738529416208 -2.0992522948332 -1 9.62117145308375 882 1859 1196 1098 2982 636 1652 409 924 1293 655 885 M11906 GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 21/53 Gene Ontology BP GO:0045744 3.38184794624099e-10 6.2309206406337e-09 1100 999.272727272727 1099 3.07440722432803e-11 1 2.13086784777282 2.38049371231367 1 16.2303520149586 1480 680 841 1099 1 1463 1100 1027 1227 626 1448 886 M14060 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. 2/15 Gene Ontology BP GO:0044794 2.43855799065639e-06 4.83030066152628e-06 1270 1626.8 1100 2.70951181508695e-07 140 4.03716812404842 4.03716812404842 1 19.9220055299352 1270 2812 4178 NA 3179 930 140 401 396 2585 377 887 M16429 GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. 72/262 Gene Ontology BP GO:0098742 4.1769851715852e-17 2.13118045622748e-15 1130 1108.18181818182 1101 3.79725924689564e-18 83 2.31853908578033 2.12355898998527 1 31.5758114584015 1126 94 83 665 1101 1672 1310 3505 357 188 2089 888 M16180 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 71/173 Gene Ontology BP GO:0090101 1.19526252020615e-08 7.60219709769473e-08 480 996.727272727273 1102 1.08660229700002e-09 463 1.82732412834867 2.02162596435211 1 12.0755641743148 480 1663 1102 580 554 1421 1267 463 1405 1245 784 889 M16600 GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 49/125 Gene Ontology BP GO:0043266 5.49954696288882e-08 2.10679839510667e-07 670 1388.72727272727 1102 4.99958827306018e-09 355 1.43539438043747 1.37623333560534 1 8.89572251860831 668 929 805 1796 1110 969 1102 3488 2602 355 1452 890 M13740 GO_NEGATIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 101/307 Gene Ontology BP GO:0051048 2.39038413535672e-07 6.58667865902745e-07 620 1523 1104 2.17307672280103e-08 594 1.89145885768352 2.04518973631194 1 10.8529602029735 619 2714 594 3564 1618 978 1104 1281 2661 678 942 891 M13538 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. 18/47 Gene Ontology BP GO:0055025 8.51288224408949e-09 6.25086973545478e-08 835 1087 1105 7.73898388820912e-10 421 2.44333178003802 2.7999122992735 1 16.3391279936207 831 1317 826 546 421 1603 1300 1740 1209 1105 1059 892 M15971 GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 15/23 Gene Ontology BP GO:0048011 3.00846004872153e-08 1.38040760677831e-07 2050 1320.63636363636 1107 2.73496371805607e-09 447 1.67959244922679 1.94193713226752 1 10.6953917944441 1626 1076 1308 1107 896 2298 2048 860 447 2046 815 893 M10578 GO_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LOCALIZATION.html Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. 150/339 Gene Ontology BP GO:0051648 1.69547934792251e-08 9.33820950463136e-08 4050 2089.63636363636 1108 1.54134487362647e-09 483 1.61392151145905 -1.17227335956301 -1 10.5315085203407 4049 483 1108 1012 690 2420 4180 2687 1061 730 4566 894 M16343 GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 18/55 Gene Ontology BP GO:0010862 2.15966902347671e-08 1.087564346638e-07 1940 1323.54545454545 1110 1.96333549516136e-09 762 2.20152741058896 2.13176014240146 1 14.2306134503336 1939 960 817 762 784 3022 1593 1005 1203 1110 1364 895 M11178 GO_REGULATION_OF_HORMONE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_LEVELS.html Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 229/704 Gene Ontology BP GO:0010817 5.31827174477914e-08 2.05944417940029e-07 920 1069.27272727273 1111 4.83479261212986e-09 375 1.75480832251195 1.9310761461396 1 10.8913428346422 919 757 376 1127 1099 1201 1111 1669 1828 375 1300 896 M11991 GO_RESPONSE_TO_METHYLMERCURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METHYLMERCURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. 5/14 Gene Ontology BP GO:0051597 1.30119457795643e-05 2.21217371858356e-05 1090 1643.36363636364 1114 1.3012021970022e-06 573 2.08293140957442 -2.08293140957442 -1 9.00079046687157 1089 1268 3839 2433 2991 861 1004 632 573 2273 1114 897 M10519 GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 13/54 Gene Ontology BP GO:0030800 1.628975904352e-06 3.40844304817771e-06 835 1389.72727272727 1115 1.48088828228911e-07 459 2.08799519935379 2.19423180766744 1 10.5970008675014 833 2065 1115 2270 2144 545 459 1059 2459 1776 562 898 M12805 GO_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. 50/169 Gene Ontology BP GO:0030216 6.96152423795149e-08 2.47301890105652e-07 1305 1149.09090909091 1115 6.3286585983973e-09 380 2.3458579497246 2.66794207807324 1 14.3866673922131 1305 2348 452 380 1212 2051 1337 1115 792 762 886 899 M13912 GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. 5/21 Gene Ontology BP GO:0002921 7.62697848401223e-08 2.64664133791247e-07 755 1593.63636363636 1115 7.62697874578083e-09 18 1.53578650836581 1.53578650836581 1 9.37665541000065 751 1346 4155 2156 3110 241 18 869 1115 3282 487 900 M12445 GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH.html Any process that controls the length of actin filaments in a cell. 90/207 Gene Ontology BP GO:0030832 2.50141948483807e-08 1.20434380196417e-07 1295 1243.72727272727 1117 2.27401773934494e-09 493 1.6384593602964 1.95160986340846 1 10.523587096921 1291 493 1117 636 846 2394 993 1424 1028 1581 1878 901 M16196 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. 56/124 Gene Ontology BP GO:0033138 6.25952982852244e-08 2.30162001994041e-07 485 1027.27272727273 1118 5.69048182420105e-09 67 1.75748610723282 1.98231443124391 1 10.8291927230561 481 2039 1510 1118 1166 253 211 1075 1614 1766 67 902 M13317 GO_GLYCOPROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 7/29 Gene Ontology BP GO:0006516 6.23381148705727e-07 1.47220685322517e-06 1055 1296.63636363636 1119 6.2338132357762e-08 259 1.52605398664191 -1.52605398664191 -1 8.26149920440321 1052 1338 4052 1358 2139 454 681 259 1119 1312 499 903 M10188 GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 15/42 Gene Ontology BP GO:0052646 1.17689770933505e-08 7.52663369757937e-08 745 1227.09090909091 1120 1.06990701420991e-09 549 1.76382598449746 -1.68010750169167 -1 11.6630504792604 744 1081 1646 1945 549 721 1775 1413 1594 1120 910 904 M10756 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. 44/124 Gene Ontology BP GO:0051149 2.57153513406062e-06 5.05916848620486e-06 1120 1249.63636363636 1120 2.33776194534592e-07 662 2.05489944799931 2.15721336262728 1 10.1018565082342 1120 662 1008 1342 2283 1838 910 1252 1403 981 947 905 M13509 GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 578/1576 Gene Ontology BP GO:0044092 3.3558800231285e-09 3.90170380050873e-08 1330 1403.09090909091 1120 3.35588002819637e-10 144 1.6428576851069 1.99660732821702 1 11.2983172805905 1326 454 4089 514 144 2909 1409 1120 1850 780 839 906 M10238 GO_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_SECRETION.html The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. 15/54 Gene Ontology BP GO:0014047 8.43986952582019e-09 6.22004987434653e-08 2390 1497.45454545455 1121 7.67260868927098e-10 47 2.77413232801605 3.20991471550018 1 18.5567959284096 2389 415 858 275 416 3780 3267 2354 47 1121 1550 907 M14286 GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE.html Any process in by an organism or tissue maintains a population of neuronal stem cells. 18/36 Gene Ontology BP GO:0097150 5.61739331190179e-08 2.13556001798919e-07 4565 1935.09090909091 1122 5.10672132303101e-09 141 2.42430612277258 -1.81747456444439 -1 15.0111586909225 4564 395 606 314 1122 2723 4606 1576 141 818 4421 908 M16450 GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. 12/19 Gene Ontology BP GO:1900119 1.01551539961445e-07 3.31524311438036e-07 800 1132.45454545455 1122 9.2319586044585e-09 171 2.2359612718731 2.66831453178421 1 13.4485008866571 797 2330 1499 1151 1338 715 246 171 1122 2816 272 909 M13739 GO_MAMMARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. 84/219 Gene Ontology BP GO:0030879 4.56297404283325e-09 4.52689924805016e-08 2420 1843.63636363636 1124 4.14815822936109e-10 285 2.03739506275649 2.00927984996266 1 13.8895709796269 2420 1124 285 646 458 3742 2569 4043 1029 348 3616 910 M16172 GO_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_IMPORT.html The directed movement of amino acids into a cell or organelle. 7/29 Gene Ontology BP GO:0043090 1.63439911434432e-08 9.12081140372679e-08 1175 1316.81818181818 1126 1.63439912636499e-09 86 2.47555572729428 2.59903061435362 1 16.1775383493884 1175 1704 4523 1126 703 1338 1090 86 808 1318 614 911 M15864 GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of stem cell proliferation. 32/102 Gene Ontology BP GO:2000648 3.14747034792606e-08 1.410589268863e-07 2120 1592.18181818182 1127 2.86133672086901e-09 473 1.61299533665791 1.92635597426099 1 10.2572471289148 2118 537 1065 588 924 3673 1979 2383 1127 473 2647 912 M10130 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 22/102 Gene Ontology BP GO:0018958 5.07684592116413e-08 1.98918106430085e-07 3950 2280.54545454545 1128 4.61531458029122e-09 363 2.51752910988506 -2.26711699500729 -1 15.6604545212552 3947 1061 667 1128 1086 4307 4277 3405 363 882 3963 913 M16261 GO_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. 70/170 Gene Ontology BP GO:0030217 2.02145514424006e-08 1.04053395063266e-07 1255 1297.18181818182 1128 1.83768651164914e-09 391 1.86450826404242 2.18398675693653 1 12.0853588938798 1252 1128 937 391 758 2816 1932 1772 1100 837 1346 914 M16435 GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity. 15/40 Gene Ontology BP GO:0035587 1.0332484544893e-07 3.35425299828286e-07 340 1092.72727272727 1128 9.39316820924253e-09 129 2.00809396142764 2.00809396142764 1 12.0684910607483 340 1555 1392 2631 1346 227 129 925 2054 1128 293 915 M16636 GO_ESTROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 10/50 Gene Ontology BP GO:0008210 1.41330657626128e-07 4.29322199725598e-07 1450 1007.36363636364 1128 1.28482424277619e-08 126 2.45597566443842 2.90470689952271 1 14.5158617391884 1128 1623 1450 421 1447 1290 308 604 126 2505 179 916 M14467 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 27/39 Gene Ontology BP GO:1902229 6.42993294112464e-08 2.32962958353193e-07 1130 1219 1129 5.84539375368371e-09 166 1.26673954276104 1.37514122454651 1 7.79915717383065 1129 818 1969 1447 1180 944 1061 893 1754 2048 166 917 M12122 GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. 9/29 Gene Ontology BP GO:0048557 1.56703758766238e-06 3.29816659996213e-06 1150 1280.90909090909 1133 1.56703869268654e-07 505 1.71497220831853 2.09057315664906 1 8.72657155837081 828 1334 3852 1146 2166 834 505 633 1146 1133 513 918 M10624 GO_RESPONSE_TO_STEROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 274/831 Gene Ontology BP GO:0048545 6.91474360167517e-25 1.45932520648081e-22 1135 993.636363636364 1135 6.28613054697741e-26 22 2.22238003633922 2.37903675562446 1 45.0461343998753 1135 466 22 258 409 2281 1359 1944 1303 64 1689 919 M15399 GO_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MIGRATION.html The movement of a lymphocyte within or between different tissues and organs of the body. 18/74 Gene Ontology BP GO:0072676 1.24874012804526e-07 3.89643845061433e-07 1140 1296.09090909091 1136 1.135218362659e-08 191 2.01990635094918 2.30272492049846 1 12.0174728636528 1136 2144 1304 1890 1406 756 191 1069 2565 1106 690 920 M14073 GO_ACTIN_MEDIATED_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MEDIATED_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. 54/134 Gene Ontology BP GO:0070252 4.83813834613182e-13 1.34511834377785e-11 1140 1347.45454545455 1137 4.39830758739353e-14 154 2.71589202408982 3.04310680641172 1 27.4069496851043 1137 1774 154 666 931 2314 1677 2847 783 157 2382 921 M14454 GO_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_POTENTIATION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. 15/63 Gene Ontology BP GO:0060291 1.49277671613724e-07 4.49770427840701e-07 1030 1252.81818181818 1137 1.35706983402487e-08 522 1.63758119366944 1.69679470824551 1 9.64808445393495 1028 689 1414 1521 1464 1137 1588 2158 522 1126 1134 922 M11220 GO_THYMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMUS_DEVELOPMENT.html The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. 29/80 Gene Ontology BP GO:0048538 6.75877831190317e-08 2.42411744027799e-07 985 1315.36363636364 1139 6.14434410867677e-09 613 1.40168779186737 1.67264155665313 1 8.60755039632496 983 1050 2016 701 1195 940 613 2639 1343 1850 1139 923 M14085 GO_RESPONSE_TO_AMINO_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINO_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 78/177 Gene Ontology BP GO:0043200 5.83404635258488e-08 2.1950953983024e-07 2240 1680.18181818182 1139 5.30367864299493e-09 387 2.33105958349948 -1.80366223800534 -1 14.407942088008 2239 504 387 892 1139 3921 2327 2858 1090 654 2471 924 M14261 GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 13/37 Gene Ontology BP GO:0009190 9.65026558555969e-06 1.67499749957958e-05 215 1309.27272727273 1140 8.77300719687153e-07 160 1.52385177648466 1.52385177648466 1 6.7557704580208 213 1617 1140 2387 2599 341 160 1410 2998 898 639 925 M14244 GO_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 21/61 Gene Ontology BP GO:0009268 7.01546760993213e-08 2.49027646123203e-07 1145 1307.09090909091 1141 6.37769803058618e-09 563 1.74296046651749 1.77769356089497 1 10.6843339658105 1141 830 1097 2266 1213 1305 895 563 2651 810 1607 926 M13891 GO_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 32/61 Gene Ontology BP GO:0071616 1.03438514861459e-08 6.96781140105641e-08 965 1406.90909090909 1142 9.40350139525463e-10 95 1.34168668022062 -1.09512256485771 -1 8.91344130290061 962 1142 2142 2663 500 95 475 2084 2256 2894 263 927 M14206 GO_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTION_POTENTIAL.html A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. 37/148 Gene Ontology BP GO:0001508 4.26758054634774e-08 1.76127790903934e-07 1145 1211.36363636364 1142 3.87961875375515e-09 282 2.29061041915347 2.4568989667128 1 14.361258225578 1142 801 334 551 1607 1852 1481 2896 430 282 1949 928 M15448 GO_THIOESTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 32/61 Gene Ontology BP GO:0035384 1.03438514861459e-08 6.96781140105641e-08 965 1403.36363636364 1143 9.40350139525463e-10 96 1.34168668022062 -1.09512256485771 -1 8.91344130290061 963 1143 2143 2664 501 96 476 2033 2257 2897 264 929 M12731 GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. 95/268 Gene Ontology BP GO:0006109 3.49336632499143e-08 1.52012182258062e-07 1145 1070.90909090909 1145 3.17578761860216e-09 453 1.69712515685119 2.02297422747107 1 10.7410749754842 722 1212 1034 1145 960 1420 1145 453 1550 1595 544 930 M13401 GO_EXOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCRINE_SYSTEM_DEVELOPMENT.html Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. 26/75 Gene Ontology BP GO:0035272 8.95002912625333e-09 6.48283700985869e-08 1685 1195.63636363636 1145 8.13639014787616e-10 438 1.46972485993396 1.72294114951407 1 9.80680260984206 1684 544 1145 1073 438 2333 1467 792 1297 458 1921 931 M15259 GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/16 Gene Ontology BP GO:0032372 1.77188931208405e-06 3.6596450516042e-06 925 1376.45454545455 1145 1.77189072490192e-07 52 3.28675585387043 3.28675585387043 1 16.5867328595513 923 446 4377 516 2206 1813 1536 1145 52 1510 617 932 M10594 GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 147/347 Gene Ontology BP GO:0033673 7.68841735804774e-09 5.92978767332486e-08 1150 1116.54545454545 1146 6.98947034992431e-10 378 1.63987351184262 1.89849894193728 1 11.0010765740544 1146 625 1165 1112 378 1458 826 973 1654 1630 1315 933 M10744 GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 10/29 Gene Ontology BP GO:0072207 5.92247501046704e-08 2.21579786249786e-07 3575 1873.36363636364 1147 5.38406833627462e-09 67 2.03713125128765 -2.08477329157795 -1 12.5835045038874 3575 423 518 370 1147 4238 2930 2768 67 413 4158 934 M16573 GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. 9/31 Gene Ontology BP GO:0032331 4.32518447232377e-08 1.78188389574084e-07 560 1343.72727272727 1147 4.32518455650627e-09 28 1.47383460389336 1.54272006775274 1 9.23347271374269 556 1416 4584 1663 1587 194 116 2857 633 1147 28 935 M10985 GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. 12/23 Gene Ontology BP GO:2000050 3.01668068465138e-07 7.9717976202825e-07 740 1088.90909090909 1148 2.74243736209481e-08 383 1.75284291448949 1.97231787476317 1 9.92272949348805 740 852 1448 1276 1685 831 383 1148 1515 1163 937 936 M14644 GO_PEPTIDYL_TYROSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_MODIFICATION.html The modification of peptidyl-tyrosine. 90/243 Gene Ontology BP GO:0018212 7.87478671742808e-09 6.00371670427235e-08 1415 1189.27272727273 1148 7.15889704146861e-10 389 1.86447338508158 2.06600116908929 1 12.4984897576793 992 1440 754 1148 389 1481 1114 1412 1411 1799 1142 937 M11202 GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/16 Gene Ontology BP GO:0032375 1.77188931208405e-06 3.6596450516042e-06 925 1314.36363636364 1152 1.77189072490192e-07 51 3.28675585387043 3.28675585387043 1 16.5867328595513 922 445 3708 515 2205 1812 1535 1152 51 1497 616 938 M14792 GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neuron migration. 9/24 Gene Ontology BP GO:2001224 5.48062041902501e-08 2.103585322142e-07 1470 1269 1152 5.48062055419242e-09 327 2.05237859228595 2.66948461358786 1 12.7206874104326 1468 867 4292 467 1152 1319 342 1297 327 1662 766 939 M13295 GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 25/69 Gene Ontology BP GO:0060393 9.5023300528106e-09 6.64805736677504e-08 1285 1214.45454545455 1153 8.63848190350311e-10 462 1.97949865273757 1.85897755466211 1 13.1882072281322 1285 1951 978 1589 462 1650 783 714 1700 1153 1094 940 M11813 GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. 5/23 Gene Ontology BP GO:0016056 6.36942356563553e-06 1.14892127487357e-05 1080 1589.63636363636 1154 6.36944182200962e-07 727 2.09387605348848 2.09387605348848 1 9.60111192380285 1076 879 3810 1627 2510 1154 911 2165 727 1500 1127 941 M10700 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 992/2850 Gene Ontology BP GO:0048584 5.62134558708492e-09 5.03859219321144e-08 1110 1490 1155 5.6213456013047e-10 198 1.7634776333156 2.06076565399508 1 11.9460560634889 1109 885 3622 978 302 3014 1552 1155 1996 198 1579 942 M13245 GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. 10/23 Gene Ontology BP GO:2000310 6.50873207996938e-06 1.17086567405261e-05 2745 1529.81818181818 1155 5.9170466692981e-07 68 2.01416314454618 -1.8511688695818 -1 9.22023928431667 2741 427 870 465 2493 1885 2274 3585 68 865 1155 943 M13311 GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 16/23 Gene Ontology BP GO:0035729 4.66111439066895e-08 1.87535130986793e-07 1595 1175.54545454545 1156 4.23737680856676e-09 206 1.94557986716533 1.94488695842688 1 12.148825417931 1530 206 1306 928 1050 1591 1156 841 531 2200 1592 944 M16851 GO_ESTROUS_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROUS_CYCLE.html A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. 11/25 Gene Ontology BP GO:0044849 1.00726567374871e-07 3.29579599944697e-07 1205 1130.63636363636 1156 9.15696108969244e-09 468 2.13993751750494 2.28687212296287 1 12.8760280275978 1203 2332 1181 1594 1336 1156 600 724 468 1014 829 945 M13705 GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 16/23 Gene Ontology BP GO:0035728 4.66111439066895e-08 1.87535130986793e-07 1595 1173.81818181818 1157 4.23737680856676e-09 207 1.94557986716533 1.94488695842688 1 12.148825417931 1531 207 1307 929 1051 1592 1157 812 532 2201 1593 946 M15391 GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/39 Gene Ontology BP GO:0032891 3.97781090165177e-06 7.4924851993384e-06 975 1351.63636363636 1159 3.6161982672122e-07 761 2.18814209553739 2.36022244458776 1 10.4104673254151 971 1094 1159 1958 2383 1565 999 1429 761 778 1771 947 M10825 GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. 12/22 Gene Ontology BP GO:0034114 1.57752812705659e-08 8.88891152175215e-08 2085 1281.81818181818 1161 1.43411648942581e-09 425 1.84758407993508 1.77759830299305 1 12.0929814632986 2084 425 1010 599 668 2628 1878 1337 488 1161 1822 948 M11589 GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 455/1065 Gene Ontology BP GO:0044087 7.45911447043156e-09 5.86001158819183e-08 1165 1114.18181818182 1161 6.78101317792886e-10 366 1.66945382881671 2.00903466333622 1 11.2074822843068 1161 608 714 393 366 2601 1562 903 1478 1193 1277 949 M11421 GO_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXON_GUIDANCE.html Any process that modulates the frequency, rate or extent of axon guidance. 15/47 Gene Ontology BP GO:1902667 0.000510359699977385 0.000693473832892889 440 1422.63636363636 1162 4.64071029585962e-05 439 2.59417046113434 2.76367126153263 1 7.60699500785619 439 2431 874 1162 3335 1088 788 1694 1242 1555 1041 950 M11805 GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE.html An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. 22/108 Gene Ontology BP GO:0002251 1.58700209083397e-05 2.65243006038233e-05 625 1288.27272727273 1162 1.44273958092787e-06 412 1.95841790034111 -1.89645222925266 -1 8.31944411149878 621 1543 663 1724 2694 526 948 1300 2578 412 1162 951 M15161 GO_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORT.html The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 24/72 Gene Ontology BP GO:0015918 2.0063015781771e-08 1.0352305921239e-07 900 1170.72727272727 1163 1.82391054224879e-09 474 2.09157452445379 2.2805953723051 1 13.5614642386097 897 1678 863 1170 755 1538 643 1163 2310 1387 474 952 M10104 GO_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DEVELOPMENT.html The progression of an endothelial cell over time, from its formation to the mature structure. 27/70 Gene Ontology BP GO:0001885 1.5108276371122e-06 3.1914343581037e-06 575 1285.36363636364 1164 1.37348061332611e-07 235 2.09705128624983 1.95979783514375 1 10.6985771489428 573 2618 1164 1014 2125 346 235 1452 1761 2430 421 953 M12714 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. 81/177 Gene Ontology BP GO:0017015 1.53507474706861e-08 8.81007670041974e-08 725 1125.63636363636 1164 1.39552250707252e-09 496 1.96420585778193 2.09894702045816 1 12.8633594507391 1233 496 644 721 653 2350 1729 1164 1278 722 1392 954 M14281 GO_MESODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. 18/48 Gene Ontology BP GO:0048333 6.24440419357368e-08 2.30162001994041e-07 370 1124.54545454545 1164 5.67673124619338e-09 367 1.71421899593906 1.71421899593906 1 10.5625915285073 367 1241 1858 1450 1164 483 712 853 1865 1935 442 955 M15850 GO_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEATH.html The process of cell death in a neuron. 40/89 Gene Ontology BP GO:0070997 8.31630450740445e-09 6.1818164081492e-08 1050 1095.09090909091 1164 7.56027685349201e-10 36 1.94530163467231 2.36939250638842 1 13.017396047048 1049 1785 1368 730 1199 1647 1164 36 644 1797 627 956 M10777 GO_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MATURATION.html Any process leading to the attainment of the full functional capacity of a protein. 145/391 Gene Ontology BP GO:0051604 5.35310503891604e-09 4.93144180469984e-08 2870 1615.72727272727 1167 4.86645913812853e-10 253 1.75036837878859 2.26833488691556 1 11.8724199944629 2870 301 742 1167 253 3110 3245 929 1288 887 2981 957 M10905 GO_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSPORT.html The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 218/695 Gene Ontology BP GO:0030001 1.92928326095621e-08 1.01452562045905e-07 1170 1369.09090909091 1167 1.75389388897728e-09 168 1.66539709381009 1.82568880654872 1 10.8117558997843 1167 614 361 1043 734 2575 1793 2531 2254 168 1820 958 M10486 GO_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical. 427/1214 Gene Ontology BP GO:0048878 5.42355559212775e-15 2.06406300116796e-13 1170 1374 1168 4.93050508375251e-16 28 1.82411888561236 1.97447716519107 1 21.4794043990304 1168 28 113 833 542 2903 1865 3134 2144 127 2257 959 M14240 GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. 51/152 Gene Ontology BP GO:0043255 3.17042888291149e-07 8.31655440867687e-07 765 1220.45454545455 1168 2.88220849073034e-08 196 1.82989892152351 2.2993785353068 1 10.3277057233204 761 1781 1134 2231 1703 1168 806 196 1412 1698 535 960 M11263 GO_IMMUNE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 383/940 Gene Ontology BP GO:0002520 6.6978498231808e-09 5.50177850965416e-08 1170 1258.54545454545 1169 6.08895440324749e-10 331 1.72345790647818 2.12269067379604 1 11.6138533898266 1169 1350 610 700 331 2866 1779 1132 1875 830 1202 961 M16599 GO_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 114/278 Gene Ontology BP GO:0030098 1.90228015514115e-08 1.0108602044243e-07 1660 1540.18181818182 1169 1.72934561053605e-09 224 1.93845535054949 2.34509990588839 1 12.5872782964195 1657 1017 706 224 726 3987 2611 2204 1169 923 1718 962 M12097 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 12/35 Gene Ontology BP GO:0050650 6.4002371049095e-06 1.15313546286747e-05 500 1399 1170 5.81841429504245e-07 500 2.01045049885211 2.17945921957149 1 9.21561085363162 500 2595 1116 2063 2489 893 534 1638 1239 1170 1152 963 M12416 GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. 12/27 Gene Ontology BP GO:1901533 3.12867656343081e-05 4.98163418518835e-05 540 1380.90909090909 1173 2.84429187093682e-06 306 1.6989133149071 -1.6989133149071 -1 6.78537985758492 540 1750 1352 1656 3018 306 965 1019 2540 1173 871 964 M12429 GO_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 58/151 Gene Ontology BP GO:0009308 1.77273653976066e-08 9.67193390612075e-08 4500 2082.27272727273 1175 1.61157868549563e-09 330 1.89680558977758 -1.63143621494649 -1 12.3505941514583 4498 330 471 1084 698 2850 4032 3283 1175 694 3790 965 M15205 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. 14/41 Gene Ontology BP GO:0035850 4.13002353954073e-07 1.03708487258451e-06 1180 1259.18181818182 1178 3.75456755896672e-08 53 2.82573534498122 2.8991054829554 1 15.6966033023049 1178 845 410 53 1777 2187 1651 2486 394 524 2346 966 M12753 GO_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_INFLAMMATORY_RESPONSE.html Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. 33/158 Gene Ontology BP GO:0002526 6.76151258790575e-08 2.42411744027799e-07 1650 1241.18181818182 1180 6.14682981428644e-09 346 2.4568692461012 2.70773586679402 1 15.0872585113634 1648 1141 346 707 1388 2862 1746 1331 901 403 1180 967 M13554 GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. 61/118 Gene Ontology BP GO:0048013 6.43244696551355e-08 2.32962958353193e-07 855 1136 1181 5.84767923053454e-09 530 1.95737192826244 2.34949906477693 1 12.0512946360649 852 1446 1254 958 1181 1989 1319 740 530 1349 878 968 M13922 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). 121/264 Gene Ontology BP GO:0097193 2.12470868291582e-09 2.99848705616357e-08 1185 1524 1181 1.93155334997074e-10 53 1.45124988554039 1.62223546664178 1 10.1346333378632 1181 2255 2309 2423 53 1013 975 932 2510 2823 290 969 M12474 GO_REGULATION_OF_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_PLASTICITY.html A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 73/229 Gene Ontology BP GO:0048167 2.9031667703492e-09 3.65029676110884e-08 1170 1133.18181818182 1183 2.63924252198207e-10 95 1.8085923402669 1.92744562434472 1 12.4866757538339 1166 1214 1040 625 95 1527 1183 1554 819 1361 1881 970 M13212 GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. 9/26 Gene Ontology BP GO:0030859 3.75067055518422e-08 1.59618362857198e-07 1065 1340.18181818182 1183 3.7506706184881e-09 45 2.66661017449635 2.89659610333472 1 16.8244410533699 1063 1183 4033 242 1011 1388 1213 1341 45 2349 874 971 M16862 GO_ACUTE_PHASE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_PHASE_RESPONSE.html An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 24/111 Gene Ontology BP GO:0006953 3.75999639193944e-07 9.59739595809501e-07 1615 1299.63636363636 1183 3.41817912232413e-08 539 2.59950331751394 2.82497956713497 1 14.5211370487526 1613 1798 539 558 1745 2821 1826 1183 705 793 715 972 M11860 GO_PEPTIDYL_PROLINE_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_HYDROXYLATION.html The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. 8/13 Gene Ontology BP GO:0019511 5.18783731815735e-07 1.25436854868692e-06 1185 1324.90909090909 1184 5.18783852927226e-08 553 1.56651067936574 1.68777143970638 1 8.58164235489548 1040 1184 3817 1200 1866 1184 1329 769 553 965 667 973 M13964 GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. 9/36 Gene Ontology BP GO:0042430 2.27461939493161e-06 4.53458902991303e-06 1500 1639.09090909091 1187 2.27462172318699e-07 576 1.96053140090217 -1.69770421661495 -1 9.72446385488127 1498 576 4167 1097 2277 807 1170 2624 1187 1139 1488 974 M15075 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 43/162 Gene Ontology BP GO:0050806 3.65955705760355e-08 1.57472876908742e-07 3380 2142.18181818182 1188 3.32687010770719e-09 620 1.91556269635137 2.25939542298092 1 12.0963081308374 3377 797 781 843 975 4363 3282 3638 620 1188 3700 975 M11856 GO_REGULATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 158/473 Gene Ontology BP GO:0042391 1.70620007549625e-08 9.38612197929988e-08 1190 1205.63636363636 1189 1.55109098975328e-09 310 1.92209579308201 2.15520295529743 1 12.5385082730785 1189 481 310 457 860 2185 1321 3509 1333 349 1268 976 M15920 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT.html Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. 11/25 Gene Ontology BP GO:0061311 2.01768352656754e-07 5.68313067791795e-07 1345 1410.36363636364 1189 1.83425791965014e-08 418 2.24132089445868 2.68297877946462 1 12.9937436217575 1345 2735 1126 483 1577 2340 848 1189 780 2673 418 977 M12526 GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. 9/23 Gene Ontology BP GO:0021681 6.03632172934488e-08 2.24932919657691e-07 2420 1625 1191 6.0363218933122e-09 81 2.40143463721367 -2.28337809042311 -1 14.8192919419012 2418 863 3924 371 1191 1523 2364 3747 81 750 643 978 M14888 GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. 20/59 Gene Ontology BP GO:0032881 4.87091410571738e-07 1.18967144623071e-06 720 1100.81818181818 1191 4.42810471287578e-08 278 1.95930636065117 2.39334826264951 1 10.7752792642429 720 1546 1191 1216 1829 1202 852 278 599 1712 964 979 M13601 GO_REGULATION_OF_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS.html Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. 10/27 Gene Ontology BP GO:0042481 2.73691221385459e-07 7.36238899706076e-07 1195 1068.09090909091 1192 2.48810232212772e-08 181 2.60287043658232 3.32503981563356 1 14.8181273619748 1192 1411 752 375 1781 1786 1367 181 304 1870 730 980 M12425 GO_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMOCYTE_AGGREGATION.html The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. 31/63 Gene Ontology BP GO:0071594 2.09807825247078e-08 1.06230941398275e-07 1195 1194.90909090909 1194 1.90734388407232e-09 291 1.78889558736277 1.83454532955851 1 11.5803167259652 1194 811 1533 291 772 2103 1421 1600 894 1375 1150 981 M14256 GO_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_IN_THYMUS.html The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. 31/63 Gene Ontology BP GO:0033077 2.09807825247078e-08 1.06230941398275e-07 1195 1209.18181818182 1195 1.90734388407232e-09 292 1.78889558736277 1.83454532955851 1 11.5803167259652 1195 812 1534 292 773 2104 1422 1747 895 1376 1151 982 M12079 GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. 11/37 Gene Ontology BP GO:0030320 1.06044522409259e-06 2.34124925128953e-06 1200 1297.54545454545 1196 9.64041577499391e-08 299 1.62982280434375 1.89457206466298 1 8.51844890022518 1196 2281 1571 1987 2174 1207 899 299 641 1000 1018 983 M13241 GO_CELLULAR_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions at the level of a cell. 11/37 Gene Ontology BP GO:0030002 1.78042069673596e-06 3.67236485781654e-06 1200 1302.36363636364 1197 1.61856557963659e-07 341 1.62982280434375 1.89457206466298 1 8.22268018709487 1197 2282 1572 1988 2175 1208 900 341 642 1002 1019 984 M10809 GO_NEURON_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. 21/65 Gene Ontology BP GO:0042551 4.9737832869246e-08 1.95871720111882e-07 785 1349.72727272727 1200 4.52162127215675e-09 530 2.09019383801773 2.13292821306236 1 13.0151920920098 784 2725 1172 1970 1081 736 530 1560 1667 1422 1200 985 M10497 GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH.html The activation of endogenous cellular processes that result in the death of a cell as part of its development. 20/41 Gene Ontology BP GO:0010623 2.81635965608231e-07 7.54550368331804e-07 295 1068.18181818182 1202 2.56032728783859e-08 117 2.02392201414287 2.02392201414287 1 11.5021320725642 293 3270 1323 1381 2334 173 121 186 1202 1350 117 986 M16933 GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. 232/511 Gene Ontology BP GO:2001233 8.52207741232581e-09 6.25086973545478e-08 1430 1240.63636363636 1202 7.74734313212502e-10 146 1.68736546524166 2.01735850188101 1 11.2838053266942 1427 1202 1100 1114 422 2905 1379 760 1734 1458 146 987 M13568 GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. 18/43 Gene Ontology BP GO:0048713 3.43630003518623e-07 8.92323325691815e-07 1495 1140.45454545455 1205 3.12390961083709e-08 86 2.18182188912524 2.83755985330319 1 12.2519809692278 1492 195 1205 230 1717 1915 1303 1028 86 2414 960 988 M13703 GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 15/45 Gene Ontology BP GO:0098815 7.80341609680652e-07 1.78479117918585e-06 1800 1254.81818181818 1205 7.0940171497139e-08 413 1.61822121348988 -1.71868114651819 -1 8.63485310728616 1800 413 1589 956 1961 1205 1649 520 1051 1558 1101 989 M14313 GO_ACIDIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSPORT.html The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/26 Gene Ontology BP GO:0015800 5.85330907099186e-06 1.06576133398491e-05 1190 1555.72727272727 1205 5.85332448860121e-07 129 2.91970977006952 2.91970977006952 1 13.4762680143164 1187 2447 4223 1205 2760 1352 811 509 129 1972 518 990 M16835 GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that modulates the frequency, rate or extent of execution phase of apoptosis. 19/35 Gene Ontology BP GO:1900117 6.90918185076751e-08 2.45818630905085e-07 1015 1322.63636363636 1207 6.28107460704813e-09 264 1.74918113778877 2.29059804513321 1 10.7316125187339 1013 1611 1403 1380 1207 1022 705 264 2336 3034 574 991 M14509 GO_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. 21/82 Gene Ontology BP GO:0046530 1.35155153083388e-08 8.22444791305599e-08 1710 1331 1209 1.2286832173973e-09 366 1.80030097223377 2.17252901142788 1 11.8398871096586 1710 390 995 1209 598 2638 2171 2144 954 366 1466 992 M16162 GO_ACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase (MAPK). 78/224 Gene Ontology BP GO:0000187 1.95425595725688e-07 5.54506521340942e-07 1155 1374.09090909091 1211 1.77659648259373e-08 668 1.61251314819846 1.87145752251228 1 9.36430643805279 1151 913 1434 1184 1564 1057 668 2371 1954 1211 1608 993 M16571 GO_COFACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. 105/181 Gene Ontology BP GO:0051188 2.57061153995117e-08 1.22332216126849e-07 685 1780.09090909091 1211 2.33691960907975e-09 130 1.03885148832749 -0.926437666504205 -1 6.66584442680682 683 1211 3213 3500 856 130 628 1875 2951 3996 538 994 M16129 GO_NEGATIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXONOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. 45/105 Gene Ontology BP GO:0050771 1.59127942792163e-07 4.7482714549101e-07 670 1236.36363636364 1212 1.44661776638208e-08 667 2.12231978325477 2.2873954946811 1 12.4576188615505 667 2086 765 993 1483 1670 1075 1386 1212 1044 1219 995 M16710 GO_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 90/182 Gene Ontology BP GO:0042542 8.65226371924554e-09 6.32637172416646e-08 1230 1253.63636363636 1213 7.86569432115781e-10 425 1.88486153321506 2.11849060577449 1 12.5953844201135 1229 907 575 1082 425 2570 1465 921 1576 1213 1827 996 M12446 GO_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that modulates the activity of a transporter. 105/288 Gene Ontology BP GO:0032409 1.4663033722309e-08 8.63965299145694e-08 1215 1206.09090909091 1214 1.33300307454894e-09 82 1.61944867610539 1.70662591566454 1 10.6183368796402 1214 82 628 1049 631 1928 1607 1843 1782 463 2040 997 M10645 GO_STEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. 27/94 Gene Ontology BP GO:0055092 2.23811790162955e-08 1.11737434594258e-07 545 1447.63636363636 1215 2.03465265854411e-09 543 1.99384449265479 2.34166250461047 1 12.8664213342155 543 2780 1227 1678 798 1215 567 940 2936 2432 808 998 M12564 GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS.html The cellular component assembly that is part of the initial shaping of the component during its developmental progression. 147/381 Gene Ontology BP GO:0010927 6.02975450762226e-09 5.16534136141885e-08 1315 1357.90909090909 1215 5.48159502195326e-10 295 1.82424082226519 2.21164894815187 1 12.3394036901267 1315 624 653 1048 295 3151 2391 1401 871 1215 1973 999 M11415 GO_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 331/883 Gene Ontology BP GO:0001775 6.54395817087783e-09 5.47858747037603e-08 1220 1371.45454545455 1216 5.94905290031183e-10 293 1.89841515511513 2.26423744279547 1 12.7960693615123 1216 1198 293 783 800 3173 1796 1375 1632 598 2222 1000 M13144 GO_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. 27/94 Gene Ontology BP GO:0042632 2.23811790162955e-08 1.11737434594258e-07 545 1445.36363636364 1216 2.03465265854411e-09 544 1.99384449265479 2.34166250461047 1 12.8664213342155 544 2781 1228 1679 799 1216 568 904 2937 2434 809 1001 M13979 GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 84/208 Gene Ontology BP GO:0090090 1.26419051180848e-07 3.92617829185736e-07 1005 1403.54545454545 1216 1.14926416768447e-08 124 1.85050137352192 2.21198136401038 1 11.0039222454894 1001 1513 1216 1109 2405 3041 1676 124 755 1699 900 1002 M14093 GO_VENTRICULAR_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_DEVELOPMENT.html The progression of the ventricular septum over time from its formation to the mature structure. 40/78 Gene Ontology BP GO:0003281 2.00454888984797e-08 1.0352305921239e-07 1410 1328.36363636364 1216 1.82231718919326e-09 664 1.39046367274236 1.39147395637029 1 9.0155636385774 888 664 1663 1174 754 1408 787 2129 2522 1216 1407 1003 M10811 GO_THYMIC_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMIC_T_CELL_SELECTION.html The process of T cell selection that occurs in the thymus. 13/27 Gene Ontology BP GO:0045061 1.52128883734597e-07 4.57470470971331e-07 845 1319.36363636364 1218 1.38298994776576e-08 191 1.85297458431452 1.91579345405102 1 10.9044303663504 844 2395 1710 1284 1467 1218 946 191 1084 2296 1078 1004 M13500 GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 10/29 Gene Ontology BP GO:0030206 3.37914455321285e-06 6.44591954008516e-06 345 1246.27272727273 1218 3.07195431227716e-07 206 2.29113383453902 2.29113383453902 1 11.0394334921297 345 2666 1218 2028 2352 497 206 1319 957 1336 785 1005 M16624 GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of cation transmembrane transport. 117/316 Gene Ontology BP GO:1904062 5.86138603870478e-09 5.09633246773526e-08 1050 1149 1218 5.32853277665552e-10 75 1.5290086666019 1.69873645008502 1 10.350705330384 1050 75 1026 1240 286 1230 1412 1860 2366 876 1218 1006 M15307 GO_DOPAMINERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. 18/46 Gene Ontology BP GO:0071542 5.61813877335838e-08 2.13556001798919e-07 850 1438.45454545455 1219 5.10739901529889e-09 742 1.78587259729421 1.97977829179052 1 11.0580163857078 848 2272 1594 742 1123 1219 847 1708 2831 1480 1159 1007 M14125 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that activates or increases the frequency, rate or extent of response to wounding. 85/245 Gene Ontology BP GO:1903036 6.90453588108777e-10 1.21430909454131e-08 1775 1551.90909090909 1220 6.27685080295883e-11 242 2.07941503897537 2.43962697195537 1 15.2791093380758 1774 774 242 674 509 3744 2642 2284 1220 272 2936 1008 M10250 GO_FATTY_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 46/95 Gene Ontology BP GO:0009062 1.62390114137563e-07 4.82391106807872e-07 820 1443.90909090909 1221 1.47627387385616e-08 274 1.26226294632252 -1.1676375126188 -1 7.40120423395312 816 933 2579 2154 1488 274 1221 614 2228 2879 697 1009 M10721 GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase C activity. 17/64 Gene Ontology BP GO:1900274 3.094163201032e-09 3.75096599018057e-08 1230 1223 1221 2.81287564125795e-10 107 2.71439182842558 2.56924125727494 1 18.7106231211449 1226 838 576 1511 107 1333 790 2943 1221 736 2172 1010 M13772 GO_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within an organism or cell. 46/109 Gene Ontology BP GO:0030104 2.69412414593213e-12 6.58358863661205e-11 1395 1286.45454545455 1222 2.4492037690322e-13 126 2.21962436220265 2.19799151395826 1 20.9778984201885 1391 126 176 832 1558 1777 1222 3779 1116 292 1882 1011 M16211 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. 41/115 Gene Ontology BP GO:0032755 2.01285143849057e-08 1.0372551863387e-07 4410 2183.81818181818 1222 1.82986496082436e-09 757 1.99157242329805 -1.5660533099203 -1 12.9114965362826 4407 1222 973 775 757 3509 3065 4157 1214 826 3117 1012 M11573 GO_OVULATION_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE.html The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 61/155 Gene Ontology BP GO:0042698 8.33473416218264e-09 6.1818164081492e-08 1140 1121.27272727273 1223 7.57703108523537e-10 413 1.96007279664109 2.03100124315758 1 13.1162403933473 1139 1357 542 1244 413 1645 1223 1483 1663 558 1067 1013 M12569 GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. 19/63 Gene Ontology BP GO:0061005 2.80075312686478e-09 3.60218747036931e-08 1810 1411.09090909091 1223 2.54613920948213e-10 44 2.622609324276 2.76146946733733 1 18.1207455478443 1807 184 268 44 1223 2872 2311 3034 321 289 3169 1014 M14755 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic hydroxy compound. 83/247 Gene Ontology BP GO:1901617 7.22693326335927e-08 2.54587641439887e-07 2445 1413.36363636364 1224 6.56993954614712e-09 99 1.76133766959447 -1.68191718932503 -1 10.7813070467041 2441 99 815 1159 1227 1224 3093 1193 1653 693 1950 1015 M15428 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. 10/20 Gene Ontology BP GO:0045943 5.20602189632702e-07 1.25762537277036e-06 1230 1636.36363636364 1228 4.73274829842427e-08 235 2.03134907547047 2.03134907547047 1 11.1259917765588 1228 3729 2575 2990 2106 1108 499 235 515 2495 520 1016 M14413 GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE.html The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. 10/36 Gene Ontology BP GO:0072661 1.39451414088603e-06 2.97264891841915e-06 665 1280.27272727273 1229 1.26774093166143e-07 664 1.94719642449787 2.03561528493219 1 9.98980649696494 664 1867 1366 1992 2110 720 1012 888 1229 1339 896 1017 M11381 GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 12/20 Gene Ontology BP GO:0090335 4.46618573477487e-07 1.10535716239657e-06 1100 1477.27272727273 1230 4.06016967404413e-08 321 1.83785513607408 2.28162410402256 1 10.1618168742917 1099 1621 2281 1230 1801 905 321 1476 1060 3393 1063 1018 M15479 GO_NEGATIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. 148/388 Gene Ontology BP GO:0007162 1.92700076921802e-12 4.86253509319524e-11 590 1071.09090909091 1230 1.75181888110882e-13 170 1.99943278841313 2.21186695225779 1 19.1410935106198 587 299 170 1198 1477 1963 1230 1519 1440 230 1669 1019 M12513 GO_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 4/33 Gene Ontology BP GO:0042417 1.92070697469192e-09 2.76094194535436e-08 2260 1440.45454545455 1231 1.92070697635202e-10 52 2.3896757230417 3.05783232352882 1 16.7675327469604 2256 883 3921 1100 52 2407 1602 346 192 1231 1855 1020 M12586 GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 4/20 Gene Ontology BP GO:0022010 1.9785066768547e-06 4.01420448786341e-06 1930 1478.09090909091 1232 1.97850843837681e-07 8 3.46056033953396 4.29157273501225 1 17.3348360202214 1928 1191 3935 316 2402 2785 1574 362 8 1232 526 1021 M14390 GO_CELL_FATE_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_DETERMINATION.html A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. 22/63 Gene Ontology BP GO:0001709 1.80665153797213e-07 5.23286530929793e-07 985 1402.63636363636 1232 1.64241062394119e-08 620 2.20172397556282 2.54993518891153 1 12.8374512744173 981 1232 620 637 1524 2222 1871 1929 1109 1203 2101 1022 M10081 GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION.html The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. 22/66 Gene Ontology BP GO:0060395 3.61314796299065e-08 1.560942952227e-07 2155 1697.27272727273 1233 3.28468002030075e-09 222 2.61528245275008 2.50237369811421 1 16.5241372532183 2154 1233 836 561 968 3302 2532 3114 222 1196 2552 1023 M12946 GO_RESPONSE_TO_AMPHETAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMPHETAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. 17/46 Gene Ontology BP GO:0001975 3.96829636509093e-08 1.66542492625827e-07 980 1220.18181818182 1233 3.60754221515446e-09 76 2.68393967847637 2.41634865267479 1 16.8878313257821 977 2558 1565 810 1546 1303 1233 76 143 2250 961 1024 M12986 GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM.html The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 4/20 Gene Ontology BP GO:0032291 1.69018204318086e-06 3.51276420165119e-06 1930 1482.63636363636 1234 1.69018332870414e-07 9 3.46056033953396 4.29157273501225 1 17.5209901648551 1929 1192 3990 317 2403 2786 1575 347 9 1234 527 1025 M11378 GO_CRANIAL_NERVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 15/59 Gene Ontology BP GO:0021602 2.32678955720819e-05 3.78398736046151e-05 715 1444.27272727273 1236 2.11528560584963e-06 512 1.99073337278462 2.19483649320322 1 8.17157759513634 712 2926 1465 1431 2763 845 512 1236 976 2038 983 1026 M14280 GO_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_CHEMOTAXIS.html The directed movement of a lymphocyte in response to an external stimulus. 13/56 Gene Ontology BP GO:0048247 2.5247651251896e-06 4.97558763847848e-06 1205 1533.36363636364 1236 2.29524365696954e-07 315 2.14161648560896 2.40121567501749 1 10.542538767592 1205 2475 1236 2440 2279 1175 315 881 2636 1295 930 1027 M12807 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. 37/94 Gene Ontology BP GO:1904427 1.39024174159208e-09 2.20303495092561e-08 3125 1771.54545454545 1237 1.26385612951874e-10 18 1.98746604177178 -1.58234227798292 -1 14.1262304526375 3124 803 1052 445 18 4025 3252 1104 1237 1544 2883 1028 M16443 GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. 22/48 Gene Ontology BP GO:0035924 1.17710128116079e-07 3.73311560685077e-07 485 1191.27272727273 1239 1.07009213103739e-08 485 1.86791047530914 1.97094614158302 1 11.1454147247873 485 1544 1239 784 1385 1345 898 1095 1172 1551 1606 1029 M11713 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 75/200 Gene Ontology BP GO:0034764 3.25413335194314e-09 3.84357595519315e-08 1505 1271.90909090909 1240 2.95830305159682e-10 115 1.79107360854204 2.11933001577163 1 12.3284710117629 1502 501 599 842 115 2935 2239 1240 1566 569 1883 1030 M10796 GO_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 646/1734 Gene Ontology BP GO:0051336 2.58313246319507e-09 3.41694701612955e-08 1240 1418 1241 2.58313246619772e-10 10 1.71058543900044 1.99762542742791 1 11.855583507076 1240 10 3638 745 88 3267 1582 1241 1697 162 1928 1031 M12931 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. 15/35 Gene Ontology BP GO:0071634 8.02181703960295e-08 2.75076045161569e-07 1245 1189 1241 7.29256121100083e-09 95 2.31086411419436 2.53335350315321 1 14.0729002904329 1241 1077 1443 1292 2030 1620 857 95 673 1557 1194 1032 M10515 GO_NEURON_PROJECTION_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION.html Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 29/84 Gene Ontology BP GO:1990138 2.13377276642945e-05 3.49457035433226e-05 735 1539.36363636364 1243 1.93981223827489e-06 731 1.76877518323073 1.83574980756015 1 7.31721856641808 731 2617 1243 1993 2742 999 794 935 2010 1207 1662 1033 M12361 GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. 22/51 Gene Ontology BP GO:0050850 2.08371702699986e-08 1.05867127625077e-07 2020 1415.45454545455 1243 1.89428822430514e-09 388 1.74947994497783 2.30144866496087 1 11.3275812924007 2020 388 1444 1243 769 3172 1931 850 1163 1199 1391 1034 M12748 GO_REGULATION_OF_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 179/457 Gene Ontology BP GO:0090087 7.50046351657047e-08 2.61839489529599e-07 1085 1498.45454545455 1243 6.81860342934901e-09 976 1.55423827274462 1.82259712047772 1 9.49603465882424 1084 2583 1362 2288 1243 1036 1173 1274 2273 1191 976 1035 M12078 GO_VENTRAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. 16/71 Gene Ontology BP GO:0021517 2.2841402486363e-05 3.72114497348011e-05 1245 1433.09090909091 1244 2.07651269451445e-06 642 2.24486489251852 2.3295271873527 1 9.22989440387574 1244 2429 1291 1915 3224 1229 809 695 1024 1262 642 1036 M12932 GO_TISSUE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MIGRATION.html The process in which the population of cells that make up a tissue undergo directed movement. 62/181 Gene Ontology BP GO:0090130 3.02781965329245e-08 1.3822254686434e-07 855 1228.18181818182 1246 2.75256335905797e-09 438 2.46941633124222 2.60991437116505 1 15.7235613016403 851 2172 438 585 901 1586 1299 1797 1246 974 1661 1037 M16507 GO_PROTEIN_AUTOPROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPROCESSING.html Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. 10/19 Gene Ontology BP GO:0016540 6.44038443878433e-06 1.15946897825807e-05 1475 1197.36363636364 1249 5.85491208431705e-07 366 2.07059699179676 -2.11743871674932 -1 9.48674139800753 1473 974 1249 1906 2491 580 1256 622 914 1340 366 1038 M11724 GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 82/222 Gene Ontology BP GO:0070304 7.45193991783307e-08 2.60341286971399e-07 1090 1420.45454545455 1250 6.77449106386234e-09 858 1.69844243730998 2.0413172833432 1 10.3810176398333 1088 1515 1046 1461 1241 1632 1097 1861 2576 858 1250 1039 M14790 GO_PEPTIDYL_PROLINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_MODIFICATION.html The modification of peptidyl-proline. 23/55 Gene Ontology BP GO:0018208 4.59917458897894e-07 1.13403970348535e-06 1250 1417 1250 4.18106868222933e-08 814 1.72775540430043 1.95411685649342 1 9.53521319043846 1250 820 1383 834 1810 2947 2469 966 814 961 1333 1040 M11981 GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. 459/1152 Gene Ontology BP GO:0051345 2.62225704182341e-09 3.4500934054886e-08 1255 1218.36363636364 1251 2.38387004086271e-10 22 1.68137078147949 1.94399666034485 1 11.6465613783585 1251 22 275 671 72 3352 1853 1582 1702 233 2389 1041 M13580 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. 79/186 Gene Ontology BP GO:2000379 4.18259720221476e-08 1.73391060802528e-07 1580 1463.45454545455 1251 3.80236116521225e-09 499 1.76945487515037 2.01655112423546 1 11.1049816839623 1579 499 840 830 1016 2836 1869 1135 2076 1251 2167 1042 M15201 GO_MATURE_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION.html The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. 8/24 Gene Ontology BP GO:0002335 6.16867241788277e-08 2.28921327882059e-07 1940 1535.72727272727 1251 6.1686725891191e-09 260 2.18994208744295 -1.55418361848416 -1 13.4986508862033 1937 1874 4368 998 1197 498 1125 1855 260 1530 1251 1043 M13312 GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 93/217 Gene Ontology BP GO:0010771 2.17291441117233e-08 1.0930489286103e-07 1005 1244.27272727273 1254 1.97537675693995e-09 721 1.85010024717457 1.94789038999425 1 11.9552459266776 1004 1659 721 814 787 2086 1254 1479 1306 748 1829 1044 M13820 GO_RESPONSE_TO_CAFFEINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAFFEINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. 10/34 Gene Ontology BP GO:0031000 3.23949850475796e-05 5.1474988218998e-05 755 1355.18181818182 1255 2.94504200666801e-06 317 1.80199485660538 1.80199485660538 1 7.17328925218742 753 1255 1399 1290 3266 564 317 1042 2597 1871 553 1045 M15027 GO_SCHWANN_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DEVELOPMENT.html The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 18/34 Gene Ontology BP GO:0014044 4.87484102174609e-08 1.93121901569685e-07 890 1820.27272727273 1255 4.43167375433146e-09 805 1.19580056562501 1.35564888687477 1 7.45281119440014 889 3088 2544 3112 1073 1097 1086 805 3137 1937 1255 1046 M15138 GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. 20/55 Gene Ontology BP GO:0002053 7.68794533621275e-08 2.65588766339552e-07 1255 1307.72727272727 1255 6.98904145897234e-09 451 1.85796831912354 2.0059576483076 1 11.3411055917741 1540 1609 1252 451 1255 1950 758 1937 920 745 1968 1047 M14169 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. 10/21 Gene Ontology BP GO:0045986 1.68033274690838e-07 4.94096576560838e-07 960 1277.09090909091 1256 1.52757534113648e-08 102 2.40793136095656 1.98199175806222 1 14.0954895347039 958 1919 1256 1734 1502 773 257 3042 1168 1337 102 1048 M13460 GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. 36/97 Gene Ontology BP GO:0042439 9.37046904959231e-09 6.64230348049727e-08 2715 1532.45454545455 1257 8.51860826318542e-10 452 1.88282878029092 -1.66082673535886 -1 12.544811316588 2713 805 1038 1257 452 1619 3336 1414 619 1194 2410 1049 M15854 GO_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_MEDIATED_ENDOCYTOSIS.html An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. 103/399 Gene Ontology BP GO:0006898 3.66425384881966e-10 6.67181592943909e-09 740 1194 1257 3.33113986311814e-11 234 2.05433608999527 2.08874097121478 1 15.5908054106595 736 633 234 1305 261 2098 1257 2769 1901 324 1616 1050 M10726 GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 10/24 Gene Ontology BP GO:0070168 1.29202817890777e-06 2.77854878863769e-06 1115 1279.54545454545 1258 1.1745717615435e-07 341 1.90096232385598 2.10481983233934 1 9.80435671040197 1115 1484 1258 954 2090 1524 1660 1782 341 862 1005 1051 M12116 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that modulates the activity of the enzyme nitric-oxide synthase. 33/73 Gene Ontology BP GO:0050999 2.75499076485473e-08 1.28945787512304e-07 1450 1301.45454545455 1258 2.50453709032237e-09 535 1.74839175255811 2.13369343009471 1 11.1815353307021 1447 535 1049 1250 876 1850 1258 1377 2131 1240 1303 1052 M12239 GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. 8/18 Gene Ontology BP GO:0042982 4.61462442940886e-06 8.54976106374515e-06 700 1744.54545454545 1259 4.61463401207825e-07 130 0.803378908541922 -0.803378908541922 -1 3.77946297014317 696 1259 3873 2045 2438 196 130 829 3446 3645 633 1053 M16339 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 28/52 Gene Ontology BP GO:0070059 4.50653046981832e-08 1.83381428320477e-07 925 1489.27272727273 1259 4.09684596557375e-09 529 1.35308663989774 1.26078903603847 1 8.46132500851516 921 1305 1871 2279 1038 853 651 1259 3102 2574 529 1054 M11460 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/65 Gene Ontology BP GO:0010765 6.28783305423936e-08 2.30162001994041e-07 1265 1357.72727272727 1261 5.71621203086571e-09 549 1.76998916339795 1.74651297222671 1 10.9062334500532 1261 549 917 1477 1170 1704 1283 3291 1353 740 1190 1055 M13810 GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS.html Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. 17/71 Gene Ontology BP GO:0021952 2.06878298166268e-06 4.16357147111392e-06 975 1536.81818181818 1261 1.8807135700523e-07 231 1.7275010545288 1.75927233055773 1 8.62805353790519 973 3552 1980 1719 2227 694 231 1261 1057 2254 957 1056 M10507 GO_POSITIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DEATH.html Any process that activates or increases the frequency, rate or extent of neuron death. 57/112 Gene Ontology BP GO:1901216 3.26827006828653e-08 1.45019201656077e-07 710 1498.45454545455 1262 2.97115465167201e-09 271 1.99863501534433 2.47029665447593 1 12.6872707805515 706 3744 1615 2185 937 1262 802 271 1399 2997 565 1057 M13455 GO_SPINAL_CORD_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_PATTERNING.html The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. 7/34 Gene Ontology BP GO:0021511 1.83586829046564e-06 3.76831851133155e-06 1480 1383.81818181818 1262 1.83586980715297e-07 94 1.90811662391799 2.47904917117707 1 9.60686992441546 1478 1262 4077 1071 2539 1381 873 354 94 1313 780 1058 M10559 GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cation channel activity. 25/56 Gene Ontology BP GO:2001259 4.60604538386602e-07 1.13452884441856e-06 1475 1243 1265 4.18731486201292e-08 404 1.76385380160571 2.05625819326466 1 9.73412799199871 1472 946 1265 717 1812 2233 1280 404 810 1150 1584 1059 M12067 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 6/15 Gene Ontology BP GO:0040037 4.79664961104032e-08 1.90597891726138e-07 1980 1507.18181818182 1265 4.79664971457564e-09 81 2.18666832052423 -2.46776985259244 -1 13.6399786297084 1979 1265 3845 957 1394 1826 3187 81 165 1077 803 1060 M12788 GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. 15/24 Gene Ontology BP GO:1903671 1.02273127135117e-06 2.26228741919176e-06 860 1657.72727272727 1265 9.29756133451452e-08 561 1.86019625540932 1.86019625540932 1 9.74824947597412 859 3694 2178 1892 2027 1039 1265 561 923 3177 620 1061 M15263 GO_OLIGODENDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DEVELOPMENT.html The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. 16/53 Gene Ontology BP GO:0014003 4.73738281534656e-09 4.60880543882876e-08 3970 1932 1269 4.30671165958894e-10 50 1.85540945088789 -1.18572337656762 -1 12.6355045958979 3969 403 1219 284 211 3253 4248 3834 50 1269 2512 1062 M14306 GO_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JNK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. 103/282 Gene Ontology BP GO:0046328 1.38548948563136e-08 8.32189868277674e-08 1135 1399.54545454545 1270 1.25953590396067e-09 610 1.6904320637721 1.98145758035911 1 11.1092942438518 1131 1979 1284 1739 610 1724 1048 1231 2316 1063 1270 1063 M12656 GO_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 375/1075 Gene Ontology BP GO:0051046 3.6348213218953e-09 4.03743430563634e-08 1155 1324.45454545455 1271 3.30438302536429e-10 160 1.72031006057987 1.98543526890593 1 11.8072596903024 1153 1271 279 1266 1130 2239 1723 1559 2267 160 1522 1064 M10213 GO_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 30/102 Gene Ontology BP GO:0051339 4.43263600434730e-09 4.46380340097457e-08 1810 1494 1272 4.0296691029803e-10 197 1.75805873083447 1.85500589252335 1 11.9951941112804 1810 675 1143 1137 197 2208 1177 2713 1834 1272 2268 1065 M10510 GO_CORONARY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORONARY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. 27/93 Gene Ontology BP GO:0060976 8.07746193771605e-05 0.000120319716961231 460 1554.18181818182 1273 7.34341683901995e-06 457 2.22556654918902 2.22556654918902 1 8.09764004781933 457 2386 1407 1971 3108 991 927 890 1255 2431 1273 1066 M12424 GO_NEGATIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 264/670 Gene Ontology BP GO:0051051 2.4249404895428e-08 1.18142693525154e-07 1090 1349.36363636364 1273 2.20449137842873e-09 492 1.6248598249049 1.86279496737226 1 10.4488238445347 1086 1507 649 1918 833 1787 1273 2002 2476 492 820 1067 M16678 GO_LENS_FIBER_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. 13/29 Gene Ontology BP GO:0070307 1.95691550092164e-08 1.02319354400666e-07 1415 1118.36363636364 1277 1.7790141075714e-09 107 2.60583720655841 2.55863993856451 1 16.9081548249144 1413 2324 955 238 742 1277 616 1578 107 1301 1751 1068 M11448 GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. 28/68 Gene Ontology BP GO:0003254 0.000105978057589414 0.000155418863356807 1280 1462.90909090909 1279 9.63483300838467e-06 769 1.84077504989968 2.18625307995671 1 6.50763794245071 1279 1537 1078 769 3034 1827 1058 1901 1409 1101 1099 1069 M10099 GO_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMORY.html The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). 43/156 Gene Ontology BP GO:0007613 2.35180569341923e-08 1.16040742131195e-07 815 1341.18181818182 1280 2.138005198691e-09 813 1.99110188434141 2.07493099881666 1 12.8183898403197 813 1726 1260 1275 819 1659 1333 1351 1280 1994 1243 1070 M13807 GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. 50/130 Gene Ontology BP GO:0050728 1.68477051375893e-09 2.54678083390043e-08 905 1192.63636363636 1282 1.53160955913557e-10 32 1.77745024887385 1.95569567122557 1 12.5296131817917 904 1369 1282 1949 32 1689 789 646 1991 1379 1089 1071 M16945 GO_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. 23/58 Gene Ontology BP GO:0019933 4.52132078097194e-06 8.40708545696946e-06 520 1223.09090909091 1282 4.1103000663383e-07 192 1.65863899206329 1.84260106552429 1 7.81425153787534 517 2265 1638 2012 2499 529 192 469 1511 1282 540 1072 M11339 GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/33 Gene Ontology BP GO:0032373 1.13937561450486e-06 2.49416359177088e-06 1285 1384.72727272727 1283 1.03579654962331e-07 328 2.15299352515547 2.56460484838718 1 11.1979441948607 1283 2523 1808 590 2046 1349 1138 542 328 2956 669 1073 M14522 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 26/45 Gene Ontology BP GO:1902042 8.57681454011224e-08 2.90884951860782e-07 2425 1644.18181818182 1283 7.79710443134893e-09 165 1.63618317614395 2.11543019065424 1 9.92731084751749 2421 165 1096 1130 1283 3893 2294 1265 1495 946 2098 1074 M13112 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). 31/111 Gene Ontology BP GO:0007200 4.73106791894082e-09 4.60880543882876e-08 920 1382.45454545455 1284 4.30097084464991e-10 209 2.53682305471115 2.29732846308783 1 17.2759923640405 918 1378 451 1652 209 1101 1284 4469 1509 833 1403 1075 M15839 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/33 Gene Ontology BP GO:0032376 1.13937561450486e-06 2.49416359177088e-06 1285 1386.36363636364 1284 1.03579654962331e-07 329 2.15299352515547 2.56460484838718 1 11.1979441948607 1284 2524 1809 591 2047 1350 1139 536 329 2971 670 1076 M10957 GO_SPHINGOMYELIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOMYELIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. 6/14 Gene Ontology BP GO:0006684 3.30998732744548e-06 6.34528123919462e-06 645 1384 1286 3.30999225766306e-07 303 1.42599367567994 -1.42599367567994 -1 6.8799507839911 641 1421 3663 2112 2366 303 313 819 1286 1719 581 1077 M14419 GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/49 Gene Ontology BP GO:0032369 1.4427791751983e-06 3.06863202494078e-06 975 1282.09090909091 1286 1.31161829216939e-07 848 1.99218543081143 2.21433635305534 1 10.1950939711612 974 1852 1490 1496 2116 1355 932 1286 848 903 851 1078 M10863 GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL.html The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 13/53 Gene Ontology BP GO:0086010 2.50650783460061e-06 4.94170525522319e-06 1175 1162.81818181818 1287 2.27864608211276e-07 197 2.49669562027384 2.47921284164445 1 12.2973649187822 1174 1559 1066 378 2278 1431 1374 749 197 1287 1298 1079 M11702 GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND.html A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. 22/47 Gene Ontology BP GO:0001702 3.03262424843955e-09 3.71516474551579e-08 1010 1252.18181818182 1287 2.75693113874538e-10 103 2.09127428603007 2.1563139328289 1 14.4234857159839 1007 2181 1287 999 103 1482 1530 1072 1460 1547 1106 1080 M11091 GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme adenylate cyclase. 13/45 Gene Ontology BP GO:0007190 1.35176496605006e-05 2.28976458860651e-05 930 1346.09090909091 1288 1.22888479262502e-06 570 2.04546364523059 1.81399441602079 1 8.81045738253176 927 570 1330 1557 2648 1002 722 2472 1578 1288 713 1081 M12183 GO_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIVISION.html The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. 16/47 Gene Ontology BP GO:0017145 3.72017548386194e-08 1.58903171771582e-07 1505 1323.45454545455 1288 3.38197776979063e-09 370 1.73944071801098 1.72309714312661 1 10.9778006392952 1501 842 1288 644 982 2327 1911 1735 1695 1263 370 1082 M16865 GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. 82/178 Gene Ontology BP GO:0071901 1.36062526192754e-07 4.16988982912843e-07 1405 1161.54545454545 1288 1.23693213279781e-08 129 1.80047060822235 2.04254209687381 1 10.6627043711033 1405 1288 1303 888 1487 1660 913 129 1110 1805 789 1083 M10300 GO_REGULATION_OF_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATURATION.html Any process that modulates the frequency, rate or extent of cell maturation. 10/24 Gene Ontology BP GO:1903429 6.81751480876267e-05 0.000102439227369207 1290 1593.27272727273 1289 6.19793280352267e-06 433 1.01019149820983 1.17807258687023 1 3.74106252182767 1289 433 2429 702 3079 1010 944 862 2009 3187 1582 1084 M12377 GO_POSITIVE_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_RATE.html Any process that activates or increases the frequency or rate of heart contraction. 13/35 Gene Ontology BP GO:0010460 4.57520358215381e-06 8.48349450157354e-06 1035 1528.36363636364 1289 4.15928463358973e-07 844 2.39893480205401 2.57711830256497 1 11.2932152297577 1034 2522 867 1588 2418 1232 901 2369 1748 1289 844 1085 M12592 GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 13/30 Gene Ontology BP GO:0034381 3.68382165506133e-07 9.43928473755505e-07 450 1412 1289 3.34892933809481e-08 206 2.28620702373949 2.28620702373949 1 12.7863365682406 449 2930 1289 3093 2307 459 273 206 2290 1782 454 1086 M16879 GO_INOSITOL_LIPID_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_LIPID_MEDIATED_SIGNALING.html A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. 64/158 Gene Ontology BP GO:0048017 3.23388053561013e-09 3.84357595519315e-08 1370 1365.63636363636 1290 2.93989140033069e-10 113 1.96341344072182 2.05832002394626 1 13.5147353005134 1368 1216 1025 894 113 2210 1822 1833 1290 906 2345 1087 M14342 GO_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASOCONSTRICTION.html Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. 35/92 Gene Ontology BP GO:0019229 3.00385685038929e-07 7.94695575860825e-07 435 1240.36363636364 1291 2.73077932775711e-08 434 2.02694637784123 1.93937674707142 1 11.476961724092 434 1898 928 1291 1684 754 671 2164 1650 711 1459 1088 M11395 GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of intracellular signal transduction. 883/2243 Gene Ontology BP GO:1902531 3.25876913513556e-09 3.84357595519315e-08 1085 1472.27272727273 1292 3.25876913991437e-10 136 1.58531355922109 1.87947693196453 1 10.9121658229175 1081 598 3736 837 136 2939 1606 1292 2052 362 1556 1089 M13778 GO_ADRENAL_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENAL_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 13/28 Gene Ontology BP GO:0030325 4.34342490173457e-06 8.10225866563021e-06 1805 1432 1292 3.94857588810251e-07 497 2.58006538240816 2.65719254038339 1 12.1937291535701 1804 850 764 1125 2406 2434 1328 1021 497 1292 2231 1090 M12634 GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). 18/46 Gene Ontology BP GO:0007205 2.16964649937765e-07 6.05388743786684e-07 895 1342.09090909091 1293 1.97240610304442e-08 691 1.88734672999379 1.90866125562035 1 10.8935428546957 893 1909 1278 691 1593 1090 1293 1321 2109 1476 1110 1091 M14745 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 6/16 Gene Ontology BP GO:0034375 4.26630631953864e-06 7.96800492422281e-06 875 1601.63636363636 1293 4.2663145101771e-07 336 2.43517310777464 2.43517310777464 1 11.5253522819386 872 2027 4285 2502 2424 852 358 934 1293 1735 336 1092 M15435 GO_CELLULAR_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. 283/767 Gene Ontology BP GO:0055082 1.4050582924275e-08 8.38685262762054e-08 700 1207.72727272727 1294 1.27732572854644e-09 350 1.71288600453811 1.87574755698539 1 11.2514897725661 697 752 350 1435 614 1587 1294 2255 2535 368 1398 1093 M15106 GO_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 57/138 Gene Ontology BP GO:0010827 5.2302321395145e-08 2.02704238929598e-07 1575 1327 1295 4.75475660350627e-09 647 1.90736829673895 2.25737270957261 1 11.8504111937753 1575 647 720 852 1098 3076 1721 1295 1407 759 1447 1094 M10968 GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 48/99 Gene Ontology BP GO:0061180 9.83551868328184e-09 6.79558232834488e-08 1610 1403.72727272727 1296 8.94138066113948e-10 471 1.99811930796809 1.8935550563325 1 13.2945859008813 1607 1296 477 582 471 2406 1431 3462 660 580 2469 1095 M13315 GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. 9/20 Gene Ontology BP GO:0035358 3.48541213201805e-08 1.51950878206195e-07 1340 1421.09090909091 1296 3.48541218668449e-09 83 1.79061001475351 1.99186782116137 1 11.3330301661795 1337 581 4050 2050 995 675 830 1296 2078 1657 83 1096 M13374 GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. 15/57 Gene Ontology BP GO:2000179 5.36888823562685e-07 1.2922627308458e-06 3325 1867 1298 4.88080867804799e-08 491 1.86240897407439 -1.09965561763321 -1 10.1802834666594 3325 1080 1298 623 1854 4234 3256 597 491 1125 2654 1097 M10163 GO_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 56/235 Gene Ontology BP GO:0007586 4.16680836593023e-09 4.30928737311998e-08 2700 1915.27272727273 1299 3.78800761256561e-10 282 2.51760240362527 -2.30086920638585 -1 17.2132981042067 2699 1293 282 557 796 4097 2426 4511 1299 444 2664 1098 M13346 GO_CARDIAC_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_FATE_COMMITMENT.html The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. 4/19 Gene Ontology BP GO:0060911 8.2951274084814e-08 2.8277736092202e-07 1300 1399.09090909091 1299 8.29512771812252e-09 59 3.38165535593895 4.29157273501225 1 20.5562544804413 1299 447 4057 135 1305 1912 2111 1858 59 1235 972 1099 M15367 GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. 13/33 Gene Ontology BP GO:0006658 6.98371904864677e-09 5.62271433403075e-08 825 1155.81818181818 1299 6.34883551892364e-10 347 1.78855632942663 -1.69500649030807 -1 12.0368541312714 824 704 1612 2104 347 552 1496 1428 1600 1299 748 1100 M14252 GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. 115/250 Gene Ontology BP GO:0006575 5.55646178794598e-08 2.12334585032372e-07 1305 1371.36363636364 1303 5.05132902571234e-09 501 1.54515007769258 -1.50827937364547 -1 9.57104980650943 1303 906 1420 2540 1116 501 1843 1433 2289 728 1006 1101 M14013 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of organic acid across a membrane. 40/133 Gene Ontology BP GO:1903825 2.98532486380382e-07 7.90693858678902e-07 920 1197 1304 2.71393206263845e-08 260 1.91962543499962 2.13089793931541 1 10.8731965261197 917 1450 920 1794 1682 1919 1584 570 1304 767 260 1102 M11340 GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. 12/29 Gene Ontology BP GO:0095500 9.25319657026289e-08 3.07314675792064e-07 2615 1704.90909090909 1309 8.41199723586568e-09 823 2.10719946431281 2.62859434482784 1 12.7384610586482 2613 853 1230 1748 1309 3103 1521 1200 823 1166 3188 1103 M11878 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION.html Any signal transduction that is involved in cellular response to ammonium ion. 12/29 Gene Ontology BP GO:1903831 9.25319657026289e-08 3.07314675792064e-07 2615 1707.90909090909 1310 8.41199723586568e-09 824 2.10719946431281 2.62859434482784 1 12.7384610586482 2614 854 1231 1749 1310 3104 1522 1221 824 1169 3189 1104 M12681 GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/33 Gene Ontology BP GO:0051953 9.50923051451645e-07 2.12772602874852e-06 690 1361.72727272727 1310 9.50923458366482e-08 83 3.35634059561461 3.35634059561461 1 17.6716800289837 689 1495 3948 683 2031 1610 1062 638 83 1310 1430 1105 M16665 GO_NEUROTROPHIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. 20/34 Gene Ontology BP GO:0038179 9.93061152628862e-09 6.84092423094333e-08 1500 1494.90909090909 1310 9.02782870101322e-10 476 1.51920278632767 1.80395116288739 1 10.1040181855637 1497 1310 1610 1246 476 2312 2119 1264 795 2646 1169 1106 M12189 GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 12/29 Gene Ontology BP GO:1905145 9.25319657026289e-08 3.07314675792064e-07 2615 1708.36363636364 1311 8.41199723586568e-09 825 2.10719946431281 2.62859434482784 1 12.7384610586482 2615 855 1232 1750 1311 3105 1523 1214 825 1172 3190 1107 M12968 GO_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 63/167 Gene Ontology BP GO:0090279 7.67321875934607e-08 2.65277399103826e-07 1605 1517.18181818182 1311 6.97565366088604e-09 1006 1.79586086197031 2.26381911622668 1 10.9628486943957 1605 1218 1286 1006 1254 2470 1642 1311 2057 1228 1612 1108 M13129 GO_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction. 11/38 Gene Ontology BP GO:0019098 5.93439485611642e-08 2.21846983228249e-07 3420 2220.18181818182 1311 5.39490456017628e-09 404 2.03571655186752 -2.10746472362259 -1 12.5737767726645 3420 1092 1056 1311 1148 3428 3002 3956 404 1001 4604 1109 M13242 GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. 12/29 Gene Ontology BP GO:0007213 9.25319657026289e-08 3.07314675792064e-07 1235 1711.18181818182 1312 8.41199723586568e-09 826 2.10719946431281 2.62859434482784 1 12.7384610586482 2616 856 1233 1751 1312 3106 1524 1233 826 1175 3191 1110 M14251 GO_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 12/29 Gene Ontology BP GO:1905144 9.25319657026289e-08 3.07314675792064e-07 2620 1707.54545454545 1313 8.41199723586568e-09 827 2.10719946431281 2.62859434482784 1 12.7384610586482 2617 857 1234 1752 1313 3107 1525 1182 827 1177 3192 1111 M15706 GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION.html Signal transduction in which the initial step occurs in a postsynapse. 12/29 Gene Ontology BP GO:0098926 9.25319657026289e-08 3.07314675792064e-07 1235 1713.45454545455 1314 8.41199723586568e-09 828 2.10719946431281 2.62859434482784 1 12.7384610586482 2618 858 1235 1753 1314 3108 1526 1232 828 1183 3193 1112 M12439 GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 21/63 Gene Ontology BP GO:0010464 7.8820518717173e-08 2.71285150781197e-07 1355 1250.36363636364 1315 7.16550195828327e-09 492 1.75813787554845 1.83771331679696 1 10.7166958525192 1353 1607 1315 492 1264 1671 622 1826 945 809 1850 1113 M16270 GO_DEFENSE_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_FUNGUS.html Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. 18/101 Gene Ontology BP GO:0050832 8.14728074653991e-07 1.85521454174521e-06 1855 1737 1315 7.4066216033924e-08 671 2.48106423829732 2.29746309138608 1 13.2002896987576 1855 833 776 1315 1971 2940 2198 4573 866 1109 671 1114 M10883 GO_ASSOCIATIVE_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASSOCIATIVE_LEARNING.html Learning by associating a stimulus (the cause) with a particular outcome (the effect). 33/113 Gene Ontology BP GO:0008306 1.26168267793526e-07 3.92127091648298e-07 1160 1450.90909090909 1316 1.14698431844707e-08 697 1.40062180494579 1.40184318310571 1 8.32944000050964 1157 1045 2376 1570 1412 1069 697 1945 1164 2209 1316 1115 M13988 GO_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_PROCESS.html A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 35/119 Gene Ontology BP GO:0022600 4.75653599076839e-07 1.16602938781086e-06 1320 1517.36363636364 1316 4.32412456287381e-08 503 2.5790848507648 2.71126744399378 1 14.2046448280425 1316 2130 503 1267 1824 1376 957 3562 1904 872 980 1116 M15108 GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. 7/19 Gene Ontology BP GO:0002313 8.82099933737227e-08 2.96386934008137e-07 2045 1575.72727272727 1316 8.82099968751742e-09 232 2.18994208744295 -1.55418361848416 -1 13.2706222843296 2041 1100 4354 822 1323 629 1249 2507 232 1316 1760 1117 M14938 GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase B. 16/37 Gene Ontology BP GO:0032148 1.24035291895826e-08 7.75095370487645e-08 2560 1948.27272727273 1318 1.12759356904667e-09 570 1.82872407650491 1.78987315198564 1 12.0705290580652 2557 1318 1004 1077 570 3892 2637 4474 631 917 2354 1118 M16275 GO_REGULATION_OF_CELL_PROJECTION_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_SIZE.html A process that modulates the size of a cell projection. 7/27 Gene Ontology BP GO:0032536 4.28862269902664e-07 1.06881777732585e-06 2080 1531.81818181818 1319 4.28862352667967e-08 114 2.24778166944022 -2.40409784750064 -1 12.4588322410478 2078 725 4540 796 1821 1432 2682 240 114 1319 1103 1119 M10782 GO_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDLIMB_MORPHOGENESIS.html The process in which the anatomical structures of the hindlimb are generated and organized. 16/54 Gene Ontology BP GO:0035137 7.17286932649829e-08 2.53259561086932e-07 4420 2434.90909090909 1320 6.52079050942015e-09 1009 2.10064664462647 -1.96811139443342 -1 12.8626772204015 4417 1320 1095 1103 1224 3994 3940 3221 1009 1260 4201 1120 M11892 GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. 154/400 Gene Ontology BP GO:1901565 2.54202095240993e-09 3.40132659424763e-08 2410 1491.90909090909 1321 2.31092814122468e-10 61 1.80380949976515 -1.31222542132273 -1 12.5050250064781 2408 61 383 744 68 3601 3091 1373 1321 1039 2322 1121 M15457 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 267/655 Gene Ontology BP GO:0007169 2.05494805130947e-08 1.05194308734618e-07 1325 1330.81818181818 1321 1.86813460954915e-09 481 1.64933621217012 1.82114131840182 1 10.6834070558261 1321 753 499 750 763 2716 1645 2125 1655 481 1931 1122 M10479 GO_VENTRICULAR_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_MORPHOGENESIS.html The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. 22/43 Gene Ontology BP GO:0060412 3.50666107551972e-08 1.52447821850544e-07 1295 1537.09090909091 1322 3.18787375583063e-09 697 1.66638628277207 1.78883607082386 1 10.5446067271899 1292 823 1015 1322 962 2231 1363 2924 2225 697 2054 1123 M12075 GO_COFACTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. 15/37 Gene Ontology BP GO:0051187 7.537860188335e-07 1.73430549328243e-06 2375 1581.09090909091 1322 6.8526025191212e-08 103 1.91960988717935 -0.81566277255509 -1 10.2652733502832 2372 1322 1210 668 1949 4111 3401 470 103 1556 230 1124 M11029 GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 49/108 Gene Ontology BP GO:0071322 8.04749449865048e-08 2.75752892673315e-07 750 1836.09090909091 1324 7.31590435729453e-09 750 1.67662316217324 1.75788678184719 1 10.2087837004033 750 3260 1911 3233 1269 1085 1207 1876 3395 1324 887 1125 M13005 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 105/299 Gene Ontology BP GO:0051924 7.35221162681134e-09 5.84526003138442e-08 1885 1322 1325 6.68382877398343e-10 356 1.845369181265 2.15812223204291 1 12.39032339234 1325 769 724 540 356 2582 1881 1885 1914 586 1980 1126 M13436 GO_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 66/188 Gene Ontology BP GO:0070555 3.80540287097496e-09 4.13781862527793e-08 710 1276.54545454545 1325 3.45945716141571e-10 150 1.8359005051238 2.05194731738891 1 12.5824319097004 709 2123 739 1961 150 1451 1208 864 2117 1395 1325 1127 M15198 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin polymerization. 47/97 Gene Ontology BP GO:0030838 9.75742534896367e-08 3.21621424699502e-07 2585 1613.27272727273 1325 8.87038707429486e-09 195 2.06480317098454 2.55940558981595 1 12.444289961117 2583 655 857 195 1325 3628 1700 2361 621 951 2870 1128 M12350 GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. 17/72 Gene Ontology BP GO:0001754 4.45044379240648e-08 1.81576542426567e-07 2300 1704.09090909091 1326 4.04585807494164e-09 414 1.88704194670536 -1.30399691997496 -1 11.8078592325574 2297 557 868 1326 1034 3620 2659 2856 968 414 2146 1129 M14841 GO_MUSCLE_FIBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FIBER_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. 20/79 Gene Ontology BP GO:0048747 8.02131614489955e-06 1.41986164166102e-05 1175 1421.36363636364 1326 7.29213217380998e-07 210 3.93661393557336 4.65833763716806 1 17.7146482734731 1173 2656 507 327 2534 2221 1654 1326 210 978 2049 1130 M14567 GO_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 46/134 Gene Ontology BP GO:0072091 1.01925108630521e-08 6.91868829490512e-08 2125 1448.45454545455 1328 9.26591900933966e-10 243 1.44962543340705 1.82320482020544 1 9.63466267478602 2125 346 1182 243 491 3814 2020 1328 1468 622 2294 1131 M11970 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 10/37 Gene Ontology BP GO:0050716 5.68733071506712e-06 1.03798256721921e-05 1230 1669.36363636364 1330 5.1703140161138e-07 172 1.83604701888404 1.85839215881933 1 8.49404196969815 1230 2402 1696 3264 2464 576 172 1114 3377 1330 738 1132 M11158 GO_L_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSPORT.html The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/67 Gene Ontology BP GO:0015807 1.81983473129577e-08 9.83642917043803e-08 2810 1662.72727272727 1332 1.654395223954e-09 664 2.18688851366986 2.9229462289153 1 14.2245314752841 2810 1392 903 1306 710 4178 2475 1332 664 957 1563 1133 M15404 GO_ADULT_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. 6/29 Gene Ontology BP GO:0007512 1.13387931664476e-06 2.48447459517773e-06 1005 1567.81818181818 1336 1.13387989520221e-07 281 3.91653907840838 3.91653907840838 1 20.3764744430433 1005 2341 4399 1134 2074 1470 902 565 281 1739 1336 1134 M15773 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. 10/22 Gene Ontology BP GO:0055026 0.000107157926471148 0.000157049953473971 1340 1539.90909090909 1336 9.74210420829842e-06 125 3.45797805406843 3.45797805406843 1 12.2103344297266 1336 2443 1484 823 3036 2085 1237 945 125 2498 927 1135 M11135 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 43/148 Gene Ontology BP GO:0003073 2.3343518679107e-07 6.45064902522306e-07 820 1419.81818181818 1337 2.12213828691053e-08 760 2.36353247057868 2.37089842988962 1 13.5815451510179 820 2463 760 1914 1612 1337 961 1825 1668 936 1322 1136 M11723 GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS.html Any process that modulates levels of neurotransmitter. 88/285 Gene Ontology BP GO:0001505 3.81664417576219e-08 1.61537638177428e-07 2150 1758.18181818182 1338 3.46967658361345e-09 718 1.83023914742669 2.03198912950071 1 11.5387070923181 2150 908 785 947 994 3714 2472 2230 1338 718 3084 1137 M14049 GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. 835/2035 Gene Ontology BP GO:0051247 5.40936807793146e-09 4.96357628178572e-08 1375 1621.36363636364 1338 5.40936809109901e-10 251 1.60688323509557 1.92629557006948 1 10.8949796963482 1374 251 4176 955 292 3931 1737 1272 2140 369 1338 1138 M10380 GO_ANTIMICROBIAL_HUMORAL_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIMICROBIAL_HUMORAL_RESPONSE.html An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. 40/176 Gene Ontology BP GO:0019730 1.80184252488638e-06 3.71490001911521e-06 1000 1267.81818181818 1340 1.63804000057448e-07 356 1.9921467036805 -1.87206911017037 -1 10.0414055756543 997 1669 566 1545 2177 433 1340 1571 2040 356 1252 1139 M12411 GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. 8/17 Gene Ontology BP GO:0050655 1.81247479786865e-06 3.73184943969141e-06 765 1572.09090909091 1343 1.81247627614954e-07 539 2.02119723882977 2.27739700490326 1 10.1841254504356 762 1699 3904 1982 2212 1055 977 1343 539 1524 1296 1140 M13549 GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. 20/70 Gene Ontology BP GO:0071622 2.36838023091572e-06 4.70132082605459e-06 1150 1579.09090909091 1344 2.15307525506114e-07 1005 1.8928880234626 1.96144983618959 1 9.36139021345338 1147 2004 1344 2153 2264 1190 1005 1088 2715 1353 1107 1141 M15808 GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. 11/49 Gene Ontology BP GO:0045721 5.62392391757139e-08 2.13556001798919e-07 1545 1299.72727272727 1345 5.11265823757947e-09 511 1.68431107608381 2.06227032631206 1 10.4291535048339 1544 1093 1345 1951 1125 1665 941 511 1921 1455 746 1142 M11157 GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. 78/206 Gene Ontology BP GO:1901136 2.75271619839953e-09 3.570072991388e-08 2735 1844.90909090909 1346 2.50246927440347e-10 79 1.70771510699516 -1.11490191929616 -1 11.8055096268968 2732 324 885 1648 79 4282 3499 1146 1346 1028 3325 1143 M10708 GO_EMBRYONIC_DIGIT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGIT_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. 30/89 Gene Ontology BP GO:0042733 1.85950380072962e-08 9.95252398516961e-08 2940 1619.63636363636 1349 1.69045801495153e-09 718 1.91285146871824 -1.80823331126388 -1 12.433019977083 2940 1793 1349 826 718 1351 3748 1029 1319 984 1759 1144 M12218 GO_ANATOMICAL_STRUCTURE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. 20/76 Gene Ontology BP GO:0071695 0.000398439570959399 0.000548297251915972 950 1899.90909090909 1351 3.62283409283695e-05 949 1.64606266204775 1.66731282406678 1 4.98269319919207 949 3296 1470 2877 3230 988 1116 1165 3371 1351 1086 1145 M13495 GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 356/869 Gene Ontology BP GO:0051347 2.00026765270457e-08 1.0352305921239e-07 1355 1498.81818181818 1352 1.81842515535569e-09 752 1.61950968078451 1.905393186673 1 10.500664579252 1352 1505 1150 1081 752 3174 1568 1920 2066 948 971 1146 M13512 GO_POSITIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXON_EXTENSION.html Any process that activates or increases the frequency, rate or extent of axon extension. 26/54 Gene Ontology BP GO:0045773 2.85428347098157e-07 7.62510825993522e-07 875 1501.18181818182 1353 2.59480349208802e-08 731 2.32461030277741 2.67542739389771 1 13.2011359160138 871 3148 1372 2047 1670 1104 1353 772 1063 2382 731 1147 M10193 GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. 25/79 Gene Ontology BP GO:0061097 9.53525708006577e-08 3.15329050019554e-07 2490 1772.36363636364 1355 8.66841590303971e-09 382 1.78951972904392 2.17243009000661 1 10.7994479971446 2489 382 1355 774 1318 4087 2506 1336 747 1842 2660 1148 M12515 GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 7/25 Gene Ontology BP GO:0070875 2.29235752909973e-05 3.73060497988435e-05 1205 1717.18181818182 1356 2.29238117650674e-06 552 2.39452804837058 2.39452804837058 1 9.84279234655829 1201 2162 3922 1457 2985 1356 1248 709 552 1963 1334 1149 M14038 GO_RESPONSE_TO_NICOTINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NICOTINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. 28/72 Gene Ontology BP GO:0035094 2.73881703064632e-06 5.35875578309772e-06 1105 1273.81818181818 1356 2.48983676386517e-07 622 2.13968598592253 2.60405385681411 1 10.4690415127616 1104 677 1000 622 2299 1819 1435 686 1608 1406 1356 1150 M14176 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a ventricular cardiac muscle cell. 7/30 Gene Ontology BP GO:0086005 6.39692561096963e-08 2.32583599152169e-07 2515 1768.72727272727 1356 6.39692579511259e-09 241 2.09002177476281 -2.04209372601509 -1 12.8693763592097 2511 241 4198 1356 1215 1976 3265 1175 690 800 2029 1151 M10256 GO_CARBOHYDRATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORT.html The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. 48/126 Gene Ontology BP GO:0008643 1.0619170348191e-07 3.4224822705571e-07 1250 2116.36363636364 1357 9.65379169160665e-09 516 1.86776308554479 1.98580467888679 1 11.209950743575 2643 516 549 1047 1357 4445 2796 4303 1250 1247 3127 1152 M12716 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 20/81 Gene Ontology BP GO:0070098 2.67896027487945e-07 7.25271869169988e-07 515 1253.63636363636 1357 2.43541872827179e-08 513 1.92528349608792 2.1267420578095 1 10.9722770988959 513 1396 537 1547 1650 1239 827 1357 2536 563 1625 1153 M13232 GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. 29/68 Gene Ontology BP GO:0033628 1.7347662665644e-08 9.48706687356714e-08 1360 1550.45454545455 1360 1.57706025476687e-09 695 1.95354453191958 2.02456129546649 1 12.7352348701518 1360 2356 1158 1347 695 1868 766 2577 1628 1209 2091 1154 M16156 GO_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the cell. 336/901 Gene Ontology BP GO:0019725 1.12376141475611e-08 7.28165368049306e-08 905 1376.81818181818 1360 1.02160129136026e-09 401 1.66877604441948 1.85429420280344 1 11.056807266557 903 1649 401 1901 534 1824 1334 2145 2609 485 1360 1155 M15820 GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION.html Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. 7/29 Gene Ontology BP GO:0007263 6.04086741019609e-05 9.14799327643198e-05 1055 1922.09090909091 1361 6.04103163083482e-06 572 3.51477536021006 3.51477536021006 1 13.1766656099509 1051 3043 4462 2315 3061 947 572 901 1361 2755 675 1156 M10180 GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. 62/154 Gene Ontology BP GO:0002244 5.49400212243509e-09 4.97122471997677e-08 1255 1199.45454545455 1363 4.99454739650466e-10 262 2.16237824487066 2.76712315040841 1 14.6600013345033 1253 1665 690 1886 262 2175 1714 365 1363 1392 429 1157 M13417 GO_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. 18/65 Gene Ontology BP GO:0042461 1.0783339123086e-07 3.46005829637101e-07 2020 1330.36363636364 1365 9.80303604693945e-09 615 1.89943716432037 2.21979730495329 1 11.3916910885766 1456 687 1146 1444 1365 2016 2016 1670 929 615 1290 1158 M15733 GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 12/29 Gene Ontology BP GO:1902893 2.86608455914729e-07 7.64833009489568e-07 1370 1391.45454545455 1366 2.60553175684638e-08 188 1.62679877655089 1.67051212660874 1 9.23636781587897 1366 2331 2087 1891 2036 920 769 188 879 2186 653 1159 M14471 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 34/81 Gene Ontology BP GO:0090280 4.36722446771709e-09 4.42011040422397e-08 3055 1863.09090909091 1367 3.97020406944226e-10 192 1.91625566326599 -1.41102831305216 -1 13.0821669959032 3053 806 951 729 192 4508 3178 1367 1646 822 3242 1160 M12103 GO_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_EFFLUX.html The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 9/31 Gene Ontology BP GO:0033344 3.31866533499667e-06 6.35404665995445e-06 1115 1595.45454545455 1368 3.31867029109992e-07 753 2.77777902003927 2.77777902003927 1 13.400325082738 1113 2021 3850 1368 2368 1816 987 863 762 1649 753 1161 M11897 GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of astrocyte differentiation. 20/50 Gene Ontology BP GO:0048710 1.11592989424642e-05 1.91969710966511e-05 780 1488.81818181818 1369 1.01448686794456e-06 722 2.16349816485693 2.32543595735255 1 9.47261996492506 778 2853 1369 1432 2608 1081 860 1659 722 2163 852 1162 M16492 GO_ISOPRENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 46/195 Gene Ontology BP GO:0006720 1.87986922444691e-07 5.38523376774754e-07 1340 1630.54545454545 1369 1.70897216825375e-08 156 2.4826088578189 2.97978448271611 1 14.4464631824696 1338 3389 1043 2070 2639 1866 858 156 1369 2570 638 1163 M16798 GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. 37/83 Gene Ontology BP GO:0007266 6.69633224342195e-08 2.40456849235948e-07 2770 1793 1370 6.08757495204005e-09 218 2.64143105923423 3.42447116568509 1 16.2292466397149 2766 1786 704 1370 1194 4641 3126 793 218 989 2136 1164 M10464 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. 31/88 Gene Ontology BP GO:0043551 1.48724838795477e-07 4.48395731511298e-07 455 1256.81818181818 1372 1.35204408045095e-08 454 1.83960328967734 1.95649949870125 1 10.8406017333607 454 1673 1240 1577 1462 958 491 942 2245 1372 1411 1165 M13098 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. 7/17 Gene Ontology BP GO:2000778 1.92517732036475e-05 3.17084012006156e-05 1555 1692.18181818182 1372 1.92519399895283e-06 593 2.23460646364117 2.8287023607662 1 9.33188431934605 1553 1339 4011 1372 2741 1924 880 1081 593 1966 1154 1166 M13446 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. 118/275 Gene Ontology BP GO:2000377 2.44161922515725e-08 1.18830587656238e-07 630 1339.27272727273 1372 2.21965386568637e-09 626 1.73023476603077 2.07514024212229 1 11.122398372552 1435 627 626 864 834 2721 1668 1372 2005 715 1865 1167 M16100 GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. 54/119 Gene Ontology BP GO:0032273 1.12702687770471e-07 3.60136668491601e-07 2385 1633.90909090909 1372 1.02456994130964e-08 212 1.98807435559924 2.35173235965201 1 11.8912029695452 2383 650 1039 212 1372 3482 1726 2415 701 1159 2834 1168 M11877 GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 31/72 Gene Ontology BP GO:0009064 2.22711709198069e-07 6.19562891435971e-07 3205 1664.63636363636 1373 2.02465210676142e-08 361 1.79609501657018 -1.64497398697035 -1 10.3500911756039 3203 361 832 746 1599 2159 3618 1291 608 1373 2521 1169 M12652 GO_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT.html The directed movement of calcium ions into a cell or organelle. 38/111 Gene Ontology BP GO:0070509 6.35879762068247e-06 1.14745034406641e-05 900 1626.18181818182 1375 5.78074181817035e-07 896 1.93989728797638 1.91806882989669 1 8.89607038405375 896 2817 1273 1809 2485 1375 1077 1402 2219 1348 1187 1170 M12954 GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. 17/31 Gene Ontology BP GO:0045652 3.60251308609811e-05 5.67191192226297e-05 1380 1544.81818181818 1377 3.2750655261969e-06 760 1.89559711592431 -1.68735929395419 -1 7.47175853686198 1377 1316 956 1728 2847 760 2153 1607 2085 993 1171 1171 M11614 GO_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_KETONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 39/102 Gene Ontology BP GO:0042180 1.92941228271665e-08 1.01452562045905e-07 1095 1362.63636363636 1378 1.75401118148882e-09 585 1.35009032837747 -1.20992220012955 -1 8.76478472494395 1093 1042 2043 1474 735 585 1594 1378 2061 1700 1284 1172 M15622 GO_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEEDING_BEHAVIOR.html Behavior associated with the intake of food. 30/131 Gene Ontology BP GO:0007631 8.31463668653676e-07 1.88408287630992e-06 1050 1514.72727272727 1378 7.55876348086895e-08 698 2.06730198852617 2.18612397531346 1 10.9860345727068 1046 1672 698 2121 1980 1378 1245 2668 1603 1273 978 1173 M16771 GO_INTESTINAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_ABSORPTION.html Any process in which nutrients are taken up from the contents of the intestine. 17/58 Gene Ontology BP GO:0050892 1.02633254191287e-07 3.33701820175172e-07 1070 1425.09090909091 1378 9.33029627084367e-09 647 2.53454923499815 2.55386967177728 1 15.2377106245991 1067 1808 647 1131 1345 1676 1432 2588 1606 998 1378 1174 M10495 GO_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WOUND_HEALING.html Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 76/209 Gene Ontology BP GO:0061041 1.75423093834558e-09 2.62738524088339e-08 1380 1403.63636363636 1379 1.5947553997676e-10 260 2.15409360810108 2.36632376457695 1 15.1575915331134 1379 780 260 1016 1178 2646 1897 1725 1605 320 2634 1175 M11707 GO_INSEMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSEMINATION.html The introduction of semen or sperm into the genital tract of a female. 6/18 Gene Ontology BP GO:0007320 2.43651258873971e-05 3.94859614293838e-05 960 1635.18181818182 1379 2.43653930382313e-06 663 2.07703496923161 2.27449879750327 1 8.49017399102007 960 1763 3792 2149 2784 1038 676 1298 1485 663 1379 1176 M14868 GO_MAST_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a mast cell. 10/51 Gene Ontology BP GO:0002448 6.03117886977238e-05 9.13928312413615e-05 1180 1920.63636363636 1379 5.48304019778773e-06 314 4.31882156124614 4.31882156124614 1 16.1926414242 1177 3802 1440 1849 4203 1368 314 1158 1379 3211 1226 1177 M10591 GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. 121/338 Gene Ontology BP GO:0070302 2.38665888387015e-08 1.16767726004311e-07 1385 1541.09090909091 1381 2.16968991796517e-09 828 1.62344092540107 2.02507885346732 1 10.4473609910695 1381 1832 1339 1786 828 2074 1238 1485 2469 1327 1193 1178 M11324 GO_PITUITARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PITUITARY_GLAND_DEVELOPMENT.html The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. 17/63 Gene Ontology BP GO:0021983 3.61621586526756e-08 1.560942952227e-07 3335 1862.09090909091 1381 3.28746902246231e-09 487 2.1723543473592 -1.74759450523131 -1 13.725584886764 3334 1157 849 487 970 2225 3959 3115 904 1381 2102 1179 M11935 GO_REGULATION_OF_GLOMERULAR_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULAR_FILTRATION.html Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. 8/13 Gene Ontology BP GO:0003093 1.75939631015852e-06 3.6419425180856e-06 950 1444.36363636364 1384 1.75939770312399e-07 330 2.1197802647682 2.1197802647682 1 10.7016918154416 948 1701 3829 1667 2568 753 330 352 1384 1522 834 1180 M12332 GO_CARDIAC_ATRIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_ATRIUM_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. 18/55 Gene Ontology BP GO:0003230 2.39239500315247e-06 4.74467359027387e-06 1385 1465.90909090909 1384 2.17490691342893e-07 487 2.53136333825664 2.73148530667142 1 12.5096406893281 1384 2184 979 1223 2266 1772 1325 766 487 1927 1812 1181 M15965 GO_RESPONSE_TO_GONADOTROPIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GONADOTROPIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 17/37 Gene Ontology BP GO:0034698 0.000101818151475289 0.000149602212607794 1295 1836.27272727273 1384 9.25662400220514e-06 648 2.43589403241679 2.30126257892273 1 8.64900205990802 1294 2274 777 2155 3202 1111 648 3316 3304 1384 734 1182 M16247 GO_LIMBIC_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMBIC_SYSTEM_DEVELOPMENT.html The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. 57/180 Gene Ontology BP GO:0021761 1.11454997781032e-08 7.24769684450046e-08 1445 1288 1386 1.01322725768798e-09 532 2.04133971503846 2.27856340450614 1 13.5291485709349 1442 2460 1386 544 532 2067 1400 871 1270 1571 625 1183 M11326 GO_DEVELOPMENTAL_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_INDUCTION.html A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). 12/39 Gene Ontology BP GO:0031128 1.18843573483099e-07 3.76392027068232e-07 2450 1557 1387 1.08039618093642e-08 561 2.04262048794354 -2.23519920417194 -1 12.181104247209 2448 572 1396 655 1387 2136 1470 1276 561 1165 4061 1184 M10384 GO_INTERMEDIATE_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. 25/72 Gene Ontology BP GO:0045103 2.11042069322311e-06 4.23818480909814e-06 1680 1580.72727272727 1388 1.91856610701336e-07 481 2.72843266662486 3.11348581509762 1 13.6076984376594 1678 1054 481 835 2231 3317 2863 1388 907 871 1763 1185 M15573 GO_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. 24/132 Gene Ontology BP GO:0009620 4.29123035196188e-07 1.06889391224029e-06 1460 1522.45454545455 1388 3.90111926272001e-08 558 2.49947604788942 2.34803094913814 1 13.8538328315295 1458 1679 887 1175 1789 2054 1279 3477 1003 1388 558 1186 M10829 GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an alpha-amino acid. 114/255 Gene Ontology BP GO:1901605 3.16482668940607e-08 1.41700003075337e-07 3215 1576.27272727273 1389 2.87711521357629e-09 490 1.64441067722581 -1.58506023478151 -1 10.454015377529 3214 490 780 1389 926 1037 3330 1541 1789 784 2059 1187 M10096 GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION.html The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. 6/18 Gene Ontology BP GO:0002031 1.68804139568268e-07 4.94796477282493e-07 1605 1664.18181818182 1390 1.68804152390946e-08 772 2.75589270054575 2.16198047558491 1 16.1308044653111 1601 1103 3532 1417 1539 1390 828 3894 1159 1071 772 1188 M10205 GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 11/30 Gene Ontology BP GO:0035588 1.25792882459835e-06 2.72160462842971e-06 500 1162.63636363636 1390 1.14357231260437e-07 156 2.1646870911854 2.1646870911854 1 11.1826075675946 499 1865 1390 2030 2079 286 156 1126 1693 1440 225 1189 M12913 GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 24/48 Gene Ontology BP GO:0070169 4.36965469640061e-09 4.42011040422397e-08 2040 1392.27272727273 1390 3.97241336825422e-10 193 2.44810576435058 2.74767872503041 1 16.7130770466793 2040 1390 648 202 193 3594 2471 1406 308 790 2273 1190 M15685 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 39/149 Gene Ontology BP GO:0021954 1.06713225555437e-06 2.35489309056034e-06 1125 1475.72727272727 1391 9.70120702889111e-08 920 2.00959525285684 2.19028085183056 1 10.4986641142419 1121 2715 968 1231 2034 1391 1078 1893 1454 920 1428 1191 M14190 GO_POSITIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GROWTH.html Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. 157/393 Gene Ontology BP GO:0045927 1.55407537904964e-08 8.84261272662679e-08 1860 1394.72727272727 1392 1.41279580911599e-09 335 2.01729357844171 2.39202496317675 1 13.2080270376811 1859 622 454 609 662 3698 2584 1392 1462 335 1665 1192 M11071 GO_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH.html Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). 653/1569 Gene Ontology BP GO:0008219 5.79835543034396e-09 5.0871514261604e-08 1165 1484.09090909091 1393 5.79835544547337e-10 309 1.65465771047335 1.91925230061605 1 11.2024960023177 1165 994 3683 1756 309 2358 1407 1393 2211 603 446 1193 M16893 GO_EMBRYO_IMPLANTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_IMPLANTATION.html Attachment of the blastocyst to the uterine lining. 22/60 Gene Ontology BP GO:0007566 6.26243872010943e-08 2.30162001994041e-07 2085 1830.81818181818 1393 5.69312627124881e-09 633 2.33958221625099 2.41898519211116 1 14.4159243851916 2083 1393 633 1091 1167 3675 2684 3678 838 1206 1691 1194 M13694 GO_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. 21/60 Gene Ontology BP GO:0086003 1.49552696739978e-07 4.50306855359091e-07 1395 1421.27272727273 1394 1.35957006278497e-08 439 2.27359583311741 2.38934688666856 1 13.3941790135255 1394 2469 796 872 1465 1505 1134 2793 439 627 2140 1195 M15507 GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. 90/232 Gene Ontology BP GO:0030177 3.21195736993211e-06 6.17776224879651e-06 1720 1768.72727272727 1394 2.91996550848838e-07 791 2.10064895232156 2.43989895831947 1 10.1575986031288 1716 1939 1394 937 2338 4284 2347 1039 791 1390 1281 1196 M10415 GO_SKELETAL_MUSCLE_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_TISSUE_REGENERATION.html The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. 23/42 Gene Ontology BP GO:0043403 9.04944851565049e-09 6.50411601519585e-08 1395 1333.54545454545 1395 8.22677141170395e-10 401 2.10403044282246 2.08093128266036 1 14.0364545125723 1395 1850 1238 1030 442 2090 1453 1951 1542 1277 401 1197 M16728 GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. 185/481 Gene Ontology BP GO:0002237 3.60307399190278e-08 1.55909343377489e-07 980 1434.18181818182 1397 3.27552186446594e-09 343 1.85197820864122 2.08606008177558 1 11.702237686433 979 1653 343 651 967 2529 1397 1955 2205 1092 2005 1198 M16931 GO_PROTEIN_HETEROOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 84/185 Gene Ontology BP GO:0051291 6.19265965582309e-08 2.28921327882059e-07 2985 1700 1397 5.62969075466991e-09 318 1.95076138477687 2.43019965237347 1 12.0243576291886 2981 318 419 1397 1161 4092 2389 1630 988 710 2615 1199 M14851 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell migration. 78/152 Gene Ontology BP GO:0010634 1.22451080053476e-07 3.8465050004516e-07 1245 1412.18181818182 1398 1.11319169880957e-08 232 1.78064226312193 1.78125795187971 1 10.6032251420304 1242 779 389 806 1398 2307 1706 2143 1798 232 2734 1200 M11452 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. 12/24 Gene Ontology BP GO:2000725 4.97173803392712e-07 1.20794242237172e-06 1020 1336.90909090909 1399 4.51976287043733e-08 431 2.74441429849224 3.22332304120646 1 15.0761474953313 1017 1479 1412 1149 1837 1953 1399 778 431 2179 1072 1201 M16502 GO_CELLULAR_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 45/137 Gene Ontology BP GO:0035690 5.42483146959967e-06 9.95199280375298e-06 1225 1568.54545454545 1400 4.93167713306501e-07 606 2.05121361960741 2.32890057820818 1 9.52426611239635 1225 2216 855 1186 2452 2100 2191 606 1717 1306 1400 1202 M11454 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 63/113 Gene Ontology BP GO:0008630 1.8693986502033e-08 9.97657233665967e-08 980 1512.18181818182 1403 1.69945333280734e-09 723 1.60033886133853 1.96292813593974 1 10.4002150468835 978 1984 2195 1619 723 1403 907 1228 1652 2768 1177 1203 M11644 GO_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 180/425 Gene Ontology BP GO:0002521 1.29427161535866e-08 8.0231016156345e-08 1025 1281.36363636364 1403 1.17661056633902e-09 450 1.85423316609028 2.2127908765305 1 12.2131062960259 1022 1586 625 450 582 2585 1814 1403 1543 1053 1432 1204 M10337 GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-5 production. 7/42 Gene Ontology BP GO:0032674 6.71503114285074e-07 1.56830430564668e-06 1405 1426.63636363636 1404 6.71503317197554e-08 545 1.82826477060255 -1.82826477060255 -1 9.85095311147207 1404 1419 3567 1771 1945 586 1043 626 831 1956 545 1205 M10993 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte migration. 16/39 Gene Ontology BP GO:2000403 7.35810261872719e-07 1.69799554963968e-06 1415 1276.54545454545 1404 6.6891864361032e-08 450 2.37001850624188 3.06696785206443 1 12.6940867385464 1414 1686 627 764 1942 2527 1827 450 726 675 1404 1206 M13284 GO_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions within an organism or cell. 28/98 Gene Ontology BP GO:0055081 9.9915709362359e-09 6.85740984125671e-08 1655 1384.81818181818 1405 9.0832463469217e-10 479 1.68406209759245 1.97275529420918 1 11.1988417312161 1655 1795 1142 1068 479 1907 1483 1057 2210 1405 1032 1207 M14917 GO_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEATH.html Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 854/2183 Gene Ontology BP GO:0010941 4.01478656232646e-09 4.25585707965337e-08 1150 1556.27272727273 1405 4.01478656957978e-10 195 1.68838982130494 1.89740166058267 1 11.5523153337457 1150 741 4316 1309 195 2748 1451 1405 2062 228 1514 1208 M14748 GO_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY.html The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. 22/45 Gene Ontology BP GO:0014896 8.82714018324365e-06 1.54425063567446e-05 490 1532.45454545455 1406 8.02470509172625e-07 482 1.98472291171092 2.10882423149602 1 8.86400203679278 487 2552 1406 3094 2562 482 690 719 2557 1549 759 1209 M10396 GO_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or around a point. 47/126 Gene Ontology BP GO:0009798 8.05609542130649e-09 6.09517268535486e-08 1275 1235.54545454545 1407 7.32372313709709e-10 100 2.27934189649308 2.17289232378933 1 15.2656670860136 1272 2260 708 100 399 1877 1507 1834 715 1407 1512 1210 M11929 GO_RESPONSE_TO_INTERFERON_ALPHA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_ALPHA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. 18/37 Gene Ontology BP GO:0035455 5.5281547533912e-08 2.11601174938131e-07 1760 1463.81818181818 1408 5.02559535663868e-09 404 1.57492917701138 1.80825298730542 1 9.7577058784692 1759 404 1622 1204 1114 3068 1863 1408 550 1103 2007 1211 M10127 GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION.html Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. 14/22 Gene Ontology BP GO:0051900 7.42687878490361e-05 0.000111163759504537 1935 1717.36363636364 1409 6.75193592485256e-06 714 1.6282555311108 1.84196482818035 1 5.97630004768963 1935 847 1335 1066 2984 2722 1304 2935 1640 1409 714 1212 M10776 GO_GLUCOCORTICOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. 4/24 Gene Ontology BP GO:0008211 3.00457644890559e-06 5.82230736739093e-06 1070 1740.18181818182 1409 3.00458051127916e-07 29 2.15272330468563 2.15272330468563 1 10.4608299001553 1070 2703 3631 1409 3330 836 149 2616 29 3107 262 1213 M13753 GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 15/48 Gene Ontology BP GO:0070873 1.3751041061971e-06 2.93680237583861e-06 1425 1358.18181818182 1411 1.25009542336636e-07 321 2.17622531702246 2.73135453616517 1 11.1754494638317 1068 2098 1411 1424 2739 1423 1118 321 739 1559 1040 1214 M15424 GO_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 139/358 Gene Ontology BP GO:0009636 3.17304750659683e-08 1.41794606093639e-07 1425 1504.54545454545 1411 2.884588683965e-09 413 1.88754854936083 2.22268209319387 1 11.9992084444379 1422 1208 413 1411 928 3310 1685 1353 1970 832 2018 1215 M16094 GO_SERTOLI_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. 16/26 Gene Ontology BP GO:0060008 7.09049272675689e-08 2.51114856829384e-07 2410 1932.72727272727 1413 6.4459026866182e-09 677 2.3235335958195 2.62680963901499 1 14.2354245426819 2406 841 697 1413 1221 3589 2608 3836 724 677 3248 1216 M10076 GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that activates or increases the frequency, rate or extent of protein maturation. 10/42 Gene Ontology BP GO:1903319 2.15931026740949e-05 3.53265594488452e-05 3845 2240.36363636364 1415 1.96302860130161e-06 154 2.45568456110027 -1.68737297674267 -1 10.1481524534816 3841 1173 1132 984 2744 4541 3619 1415 154 859 4182 1217 M14600 GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS.html Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. 26/64 Gene Ontology BP GO:0097006 1.27349192582072e-07 3.94978157086548e-07 1320 1661.18181818182 1415 1.15771999958007e-08 943 1.7767410958579 1.95651225080199 1 10.5610169346946 1320 2316 1375 2640 1415 2153 943 1234 1915 1950 1012 1218 M10982 GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 13/54 Gene Ontology BP GO:0090184 1.28232919844283e-07 3.97453569317095e-07 2275 1699.81818181818 1416 1.16575388471532e-08 104 2.15339295100674 2.36691846241075 1 12.7944263136672 2272 215 677 104 1416 2669 2135 4569 725 895 3021 1219 M12447 GO_EATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EATING_BEHAVIOR.html The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. 11/46 Gene Ontology BP GO:0042755 2.88673490823211e-06 5.61739739267463e-06 1005 1438.72727272727 1416 2.62430790552247e-07 800 2.26153983106131 2.43220139202124 1 11.0222721723674 1002 1481 1068 2352 2313 1170 800 1416 1665 1447 1112 1220 M15378 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. 14/41 Gene Ontology BP GO:0071526 0.00124955570752596 0.0016287723610452 465 1583.63636363636 1416 0.000113660544988662 463 2.60081184976 2.60081184976 1 6.73120132959029 463 2433 1060 1624 3550 1245 778 1706 1416 1908 1237 1221 M10321 GO_REGULATION_OF_COLLATERAL_SPROUTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COLLATERAL_SPROUTING.html Any process that modulates the frequency, rate or extent of collateral sprouting. 16/35 Gene Ontology BP GO:0048670 1.47596783951685e-06 3.1319495087532e-06 970 1334 1417 1.34178984521495e-07 451 1.80106444448778 1.9390931709447 1 9.20219490238333 966 2146 1417 1713 2120 823 451 1542 1179 1673 644 1222 M11794 GO_COPPER_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_TRANSPORT.html The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/20 Gene Ontology BP GO:0006825 1.01162607598799e-07 3.30540455370318e-07 1340 1549.90909090909 1417 9.19660111368722e-09 808 1.70977328119355 -1.44706110403622 -1 10.2857183711173 1913 862 2099 2191 1337 808 1336 2643 1417 1444 999 1223 M13949 GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY.html The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. 7/43 Gene Ontology BP GO:0060397 6.19314564451583e-06 1.12235656625632e-05 950 1657.27272727273 1418 6.19316290435738e-07 686 1.56025439868876 -1.79025384526688 -1 7.16899477508273 1212 1418 4163 1672 2502 686 950 1139 1572 1970 946 1224 M16677 GO_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERK1_AND_ERK2_CASCADE.html An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 14/29 Gene Ontology BP GO:0070371 2.54232592046729e-08 1.21690920089996e-07 2790 1944.81818181818 1418 2.31120540895135e-09 852 1.74971572168327 -1.28364360664133 -1 11.2308492551895 2789 1082 1237 1172 852 3155 1402 2220 2191 1418 3875 1225 M10068 GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0052192 3.56614981177708e-09 3.98870630704176e-08 910 1433.81818181818 1419 3.24195437959794e-10 129 1.62819227323501 1.82773949910746 1 11.1829841262161 908 1359 1173 1758 129 1869 1027 1790 2729 1611 1419 1226 M10524 GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0051806 3.56614981177708e-09 3.98870630704176e-08 910 1427.90909090909 1420 3.24195437959794e-10 130 1.62819227323501 1.82773949910746 1 11.1829841262161 909 1360 1174 1759 130 1870 1028 1715 2730 1612 1420 1227 M14380 GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 103/383 Gene Ontology BP GO:0071383 1.38399993115177e-07 4.22757347390635e-07 1385 1506.36363636364 1420 1.25818183474359e-08 516 2.16795896724045 2.23244520028132 1 12.8270279489256 1383 2544 516 1201 1443 1833 1420 2438 1498 1249 1045 1228 M12914 GO_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_ENTRY_INTO_HOST_CELL.html The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. 54/135 Gene Ontology BP GO:0046718 3.56614981177708e-09 3.98870630704176e-08 910 1433.27272727273 1421 3.24195437959794e-10 131 1.62819227323501 1.82773949910746 1 11.1829841262161 910 1361 1175 1760 131 1871 1029 1764 2731 1613 1421 1229 M12838 GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 73/173 Gene Ontology BP GO:0010594 1.30848307427335e-07 4.03941949059252e-07 665 1197.72727272727 1422 1.18953013827032e-08 604 1.87249506038609 1.87919823226772 1 11.1132422707775 645 1941 662 662 1422 1437 824 1539 1737 604 1702 1230 M12938 GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0051828 3.56614981177708e-09 3.98870630704176e-08 1765 1434.27272727273 1422 3.24195437959794e-10 132 1.62819227323501 1.82773949910746 1 11.1829841262161 911 1362 1176 1761 132 1872 1030 1765 2732 1614 1422 1231 M11087 GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. 32/90 Gene Ontology BP GO:0046928 1.31824900415263e-07 4.06416343046524e-07 615 1337.18181818182 1423 1.19840825740241e-08 615 1.7745044195449 1.84426301823821 1 10.5272999250342 615 1995 1709 2690 1423 730 621 1079 1613 1428 806 1232 M11401 GO_CLATHRIN_COAT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_ASSEMBLY.html The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. 6/13 Gene Ontology BP GO:0048268 4.11461029570217e-06 7.70638789953416e-06 1480 1580.09090909091 1423 4.11461791423008e-07 581 1.85575339302642 -1.85575339302642 -1 8.80801114336589 1476 988 3737 1768 2412 885 581 977 1423 2527 607 1233 M15136 GO_MOVEMENT_IN_HOST_ENVIRONMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_HOST_ENVIRONMENT.html The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0052126 3.56614981177708e-09 3.98870630704176e-08 915 1439.72727272727 1423 3.24195437959794e-10 133 1.62819227323501 1.82773949910746 1 11.1829841262161 912 1363 1177 1762 133 1873 1031 1815 2733 1615 1423 1234 M12864 GO_BONE_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MINERALIZATION.html The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. 16/53 Gene Ontology BP GO:0030282 1.06865007824978e-05 1.84588627727446e-05 1060 1589.54545454545 1424 9.715047902302e-07 844 2.5117153931944 2.55206119678564 1 11.0369484325462 1058 2097 844 2227 2603 1424 1054 1186 2127 1265 1600 1235 M13662 GO_NEGATIVE_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANOIKIS.html Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. 21/35 Gene Ontology BP GO:2000811 2.31524578807184e-07 6.41006928683217e-07 825 1329.72727272727 1424 2.10476911974976e-08 823 1.62568875349 1.56939558900163 1 9.34581630747881 823 825 1500 1463 1608 1127 1234 2014 1529 1424 1080 1236 M15286 GO_ENTRY_INTO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST.html Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0044409 3.56614981177708e-09 3.98870630704176e-08 915 1435.18181818182 1424 3.24195437959794e-10 134 1.62819227323501 1.82773949910746 1 11.1829841262161 913 1364 1178 1763 134 1874 1032 1755 2734 1616 1424 1237 M12722 GO_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. 242/660 Gene Ontology BP GO:0050708 3.10692613361702e-07 8.17306404441011e-07 945 1482 1425 2.82447870217216e-08 361 1.63177127288272 1.76260034808758 1 9.22094860244259 942 2303 710 2243 1693 1380 1143 1425 2616 361 1486 1238 M16749 GO_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST_CELL.html The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0030260 3.56614981177708e-09 3.98870630704176e-08 915 1433.45454545455 1425 3.24195437959794e-10 135 1.62819227323501 1.82773949910746 1 11.1829841262161 914 1365 1179 1764 135 1875 1033 1726 2735 1617 1425 1239 M12022 GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS.html The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. 6/15 Gene Ontology BP GO:0048703 4.63138049631646e-05 7.14876982858954e-05 1430 2242.54545454545 1426 4.63147702273166e-06 407 3.56149969168527 3.56149969168527 1 13.7058859536158 1426 3765 3842 3102 4339 1330 925 816 407 3424 1292 1240 M12558 GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids with a chain length of less than C6. 10/26 Gene Ontology BP GO:0046459 1.09525835853597e-05 1.8883344072345e-05 650 1732.63636363636 1427 9.95694373872504e-07 215 1.07936002148989 -1.07936002148989 -1 4.73301724035742 647 1410 2508 2357 2922 215 279 1427 3504 3198 592 1241 M14733 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 45/93 Gene Ontology BP GO:0090003 1.54681804457456e-08 8.82555423854249e-08 4265 2398.18181818182 1427 1.40619823222747e-09 653 1.70847382113032 -1.53077768868934 -1 11.1873906382886 4263 1136 1202 653 658 3874 3504 4527 1427 1305 3831 1242 M13823 GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. 99/225 Gene Ontology BP GO:0006352 7.19902172751711e-08 2.53935213166315e-07 1425 1742.09090909091 1429 6.54456542099043e-09 94 1.55379907349243 -1.47730758976711 -1 9.51255183521824 1423 3173 2753 2966 1225 94 1429 883 1808 2946 463 1243 M15089 GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. 76/213 Gene Ontology BP GO:0045834 1.08717525084895e-07 3.4860184321075e-07 1430 1427.36363636364 1429 9.88341185976321e-09 532 2.04186860896694 2.24801047701267 1 12.2397570366558 1429 1031 532 788 1366 2584 1845 1437 1876 703 2110 1244 M11493 GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 68/180 Gene Ontology BP GO:0051282 1.34208599782587e-07 4.12669224364604e-07 1455 1519.27272727273 1431 1.22007825427125e-08 895 1.69883246031538 2.0063789332563 1 10.0679171125662 1452 1033 1400 895 1431 2359 1499 1379 2345 1283 1636 1245 M11388 GO_MONOVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 164/504 Gene Ontology BP GO:0015672 1.25778837691889e-07 3.9167749389902e-07 4580 2271.18181818182 1432 1.14344404439038e-08 1064 1.46039589066308 -1.17558444991611 -1 8.6855894416882 4579 1432 1242 1391 1410 1401 4061 2657 2508 1064 3238 1246 M11681 GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 224/516 Gene Ontology BP GO:0090407 4.8599672314751e-09 4.67180700946975e-08 1505 1782.63636363636 1434 4.41815203837376e-10 163 1.2428722505964 -1.16415474507257 -1 8.45726845719997 1505 1003 2885 3945 225 163 1406 1434 3063 3367 613 1247 M12703 GO_CELLULAR_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. 36/154 Gene Ontology BP GO:0034754 1.5106811501798e-08 8.7574463447947e-08 3140 2138 1435 1.37334650959386e-09 642 2.16085819379174 2.47511088039124 1 14.1564327167626 3136 670 982 795 642 4510 2686 4453 872 1435 3337 1248 M16539 GO_UTERUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTERUS_DEVELOPMENT.html The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. 11/24 Gene Ontology BP GO:0060065 7.39721279884581e-08 2.5901401979669e-07 1125 1667.90909090909 1435 6.72473913415224e-09 1012 2.06590013199055 -2.32015350279253 -1 12.6312056956025 2473 2014 1121 1828 1238 1684 3020 1400 1435 1012 1122 1249 M13017 GO_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 36/99 Gene Ontology BP GO:0043550 1.00013877976146e-07 3.27478445305534e-07 675 1471.45454545455 1436 9.0921711384421e-09 671 1.80848531337486 1.95649949870125 1 10.8863392483256 671 2043 1478 1863 1335 1254 733 1208 2349 1436 1816 1250 M11529 GO_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 12/54 Gene Ontology BP GO:0006584 1.65860254132594e-06 3.45641454191039e-06 1650 1415.81818181818 1437 1.50782162887701e-07 335 2.53105699573063 3.1642295216052 1 12.8313689504936 1649 2325 996 1405 2651 1634 1513 335 462 1167 1437 1251 M12058 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation. 68/174 Gene Ontology BP GO:0030856 2.93352788913782e-08 1.35391351781977e-07 3465 1767.72727272727 1438 2.66684357114011e-09 112 1.90910697129685 -1.9061670192659 -1 12.1718208581593 3462 112 692 1422 892 1845 4002 2929 1438 567 2084 1252 M12384 GO_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that modulates the frequency, rate, or extent of a homeostatic process. 262/664 Gene Ontology BP GO:0032844 3.63495539653205e-05 5.71330328574756e-05 1000 1706 1438 3.30455950596458e-06 597 1.71492366883001 1.93577640152957 1 6.75458222436652 998 3308 1055 2425 2851 1461 998 952 2683 1438 597 1253 M15740 GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. 12/54 Gene Ontology BP GO:0009712 2.02166709459285e-06 4.08646074018049e-06 1650 1420 1438 1.8378808658047e-07 355 2.53105699573063 3.1642295216052 1 12.6605114932446 1650 2326 997 1406 2652 1635 1514 355 463 1184 1438 1254 M12808 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. 34/90 Gene Ontology BP GO:0010633 9.37004183351133e-07 2.10474621349749e-06 170 1223.18181818182 1439 8.51822347665229e-08 105 1.61541699731105 1.76664659449936 1 8.51250527375033 168 2222 1756 1565 2688 231 105 291 1439 2681 309 1255 M14457 GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 298/724 Gene Ontology BP GO:0051493 9.08362000037792e-09 6.51858541912746e-08 1355 1676.18181818182 1439 8.25783639807586e-10 444 1.73520915681003 2.18172188705154 1 11.5744112614572 1351 3570 872 1640 444 2875 1269 1024 2116 1838 1439 1256 M15370 GO_NEURAL_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_FORMATION.html The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. 64/142 Gene Ontology BP GO:0001841 1.17123060455402e-08 7.51108245434299e-08 1110 1474.36363636364 1439 1.06475510071763e-09 546 1.36854749381192 1.3795605949587 1 9.05046828829001 1110 642 2165 1034 546 1894 1439 2367 2348 1058 1615 1257 M12833 GO_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TASTE.html The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. 17/88 Gene Ontology BP GO:0050909 1.38371339462705e-07 4.22757347390635e-07 1435 1555 1442 1.25792134696108e-08 717 2.21418347126043 2.17985429933278 1 13.1005216004998 1433 1470 717 1233 1442 2083 1160 2996 1459 992 2120 1258 M11102 GO_PENTOSE_PHOSPHATE_SHUNT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_PHOSPHATE_SHUNT.html The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. 5/16 Gene Ontology BP GO:0006098 0.000115868308906566 0.000169015569667982 750 1738.09090909091 1444 1.158743508092e-05 412 0.852015861662733 -0.852015861662733 -1 2.98329990599183 748 1707 3691 2031 3123 534 412 959 1444 3272 1198 1259 M13728 GO_FEMALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_SEX_DIFFERENTIATION.html The establishment of the sex of a female organism by physical differentiation. 66/166 Gene Ontology BP GO:0046660 1.89872151304014e-08 1.0108602044243e-07 2315 1817.18181818182 1444 1.72611048129741e-09 415 2.09088001209847 2.13933059358804 1 13.5770414419501 2313 1444 415 921 725 3800 2066 3187 1287 607 3224 1260 M10306 GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING.html Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. 18/62 Gene Ontology BP GO:0010955 7.60899253270449e-07 1.7446198681159e-06 1135 1543.90909090909 1445 6.91726833125183e-08 720 1.37620385457723 1.39233360180209 1 7.35607461965131 1133 1069 1767 2309 1955 995 720 1322 2794 1474 1445 1261 M16220 GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. 18/62 Gene Ontology BP GO:1903318 7.60899253270449e-07 1.7446198681159e-06 1135 1543.63636363636 1446 6.91726833125183e-08 721 1.37620385457723 1.39233360180209 1 7.35607461965131 1134 1070 1768 2310 1956 996 721 1299 2795 1485 1446 1262 M12662 GO_NEURAL_NUCLEUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_NUCLEUS_DEVELOPMENT.html The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. 55/153 Gene Ontology BP GO:0048857 7.04365778662121e-08 2.49783808439562e-07 2100 1867.72727272727 1447 6.40332546557762e-09 709 2.01473068848587 2.23451366836363 1 12.3478208051458 2100 1447 882 1161 1216 3889 2701 2677 990 709 2773 1263 M13723 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. 13/32 Gene Ontology BP GO:1902307 3.30001807656658e-08 1.45923656471415e-07 1355 1649.63636363636 1448 3.00001647824285e-09 569 1.60693584185604 1.55033084232429 1 10.1967492379038 1354 569 1536 1448 942 1844 1434 3985 1513 2308 1213 1264 M12303 GO_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. 173/465 Gene Ontology BP GO:0019216 2.13538134055709e-08 1.07767125697897e-07 1840 1563.27272727273 1449 1.94125578298517e-09 293 1.78179791207978 2.05663462099562 1 11.5240573684842 1838 293 567 534 780 3981 2238 1449 2007 877 2632 1265 M10087 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 61/165 Gene Ontology BP GO:0051928 2.94186862797826e-08 1.35641470106286e-07 1845 1599 1451 2.67442606119754e-09 782 1.90245657930522 2.19749432538532 1 12.1280046662793 1845 925 926 782 893 3384 2286 1451 1727 935 2435 1266 M15486 GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. 22/71 Gene Ontology BP GO:0035914 2.0278816008839e-06 4.09545640404696e-06 2040 1589.45454545455 1451 1.84353042737756e-07 385 2.94294018689272 3.34730183994162 1 14.7181691872911 2037 2652 1171 1451 2220 2869 1384 1137 385 1550 628 1267 M13785 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK.html The synchronization of a circadian rhythm to environmental time cues such as light. 17/73 Gene Ontology BP GO:0009649 7.12309351451404e-08 2.51885172794278e-07 4645 2407.90909090909 1452 6.47553976831218e-09 835 1.64373340599126 -1.19984816713429 -1 10.0685124020282 4642 835 1283 1452 1222 3610 3746 4039 887 994 3777 1268 M11009 GO_SERTOLI_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. 14/21 Gene Ontology BP GO:0060009 7.42397977136993e-09 5.85221359566564e-08 3815 2294.36363636364 1453 6.74907254220218e-10 362 2.22186009632204 -1.86861953102627 -1 14.9171235316318 3813 1086 961 1453 362 4517 3803 3472 643 1017 4111 1269 M12496 GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. 26/74 Gene Ontology BP GO:1903307 1.22321952362993e-08 7.68916604102299e-08 3220 2172.45454545455 1455 1.11201775493739e-09 375 1.57788577748179 -1.29548437900432 -1 10.4199570376108 3216 375 1455 869 564 4270 3470 4029 611 943 4095 1270 M11274 GO_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORT.html The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 60/215 Gene Ontology BP GO:0006836 1.22955661060542e-07 3.84951540326431e-07 2725 2059.90909090909 1456 1.11777879938549e-08 649 1.71169748516068 1.89388129305956 1 10.1921384781397 2725 788 1091 942 1402 4299 2960 2865 1456 649 3482 1271 M14010 GO_RESPONSE_TO_CARBOHYDRATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CARBOHYDRATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 106/256 Gene Ontology BP GO:0009743 3.07705615500866e-08 1.3938313880688e-07 675 1572.18181818182 1458 2.79732381640571e-09 672 1.78810892579053 1.9425866663629 1 11.3794323036951 672 2713 1458 2407 912 1625 1376 1890 2397 771 1073 1272 M14462 GO_CELLULAR_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 6/28 Gene Ontology BP GO:0071467 1.00133347063313e-06 2.22024417581166e-06 2790 1758.63636363636 1459 1.00133392183434e-07 592 1.85487124774814 1.98617031735716 1 9.73437166646518 2788 592 4239 1135 2043 2680 1459 707 847 1081 1774 1273 M15447 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 64/136 Gene Ontology BP GO:0072329 1.45800881048968e-07 4.40438185237708e-07 1120 1366.18181818182 1459 1.32546264283317e-08 328 1.38897325734509 -1.24179156997872 -1 8.19510956356165 1118 328 2129 1727 1459 543 1766 767 1758 2228 1205 1274 M10042 GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL.html A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. 25/78 Gene Ontology BP GO:0097553 2.70167306505792e-07 7.28870891404062e-07 1350 1590.36363636364 1460 2.45606672439309e-08 917 1.91379875749757 1.9595679994599 1 10.9030059826011 1346 2227 1346 1698 1656 1917 1456 917 2104 1460 1367 1275 M11684 GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html A process in which a protein is transported to, or maintained in, the cell periphery. 84/212 Gene Ontology BP GO:1990778 1.4652078194705e-07 4.42325091404521e-07 1915 1987.90909090909 1460 1.3320071973217e-08 635 1.64422374138503 1.66657988726875 1 9.69828452802185 1914 635 1376 1445 1460 3438 2372 4356 1197 939 2735 1276 M11979 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. 27/79 Gene Ontology BP GO:2000107 1.06460168305961e-05 1.8402627008361e-05 1105 1549.90909090909 1462 9.67824395279074e-07 743 2.1541746536681 2.17180698132973 1 9.46849709534122 1105 2976 994 1922 2602 1462 1002 1504 1957 782 743 1277 M14575 GO_PEROXISOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOMAL_TRANSPORT.html Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 13/21 Gene Ontology BP GO:0043574 3.08631694550027e-06 5.96490131260973e-06 1240 1905.09090909091 1462 2.80574661383124e-07 377 0.688529336528227 -0.668631357063269 -1 3.33908684412352 1237 568 3148 2725 2326 377 506 1462 2925 4524 1158 1278 M16606 GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL.html The directed movement of calcium ion into a cytosol. 25/78 Gene Ontology BP GO:1902656 2.70167306505792e-07 7.28870891404062e-07 1350 1597.54545454545 1464 2.45606672439309e-08 983 1.91379875749757 1.9595679994599 1 10.9030059826011 1347 2228 1347 1699 1657 1918 1457 983 2105 1464 1368 1279 M16781 GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 180/463 Gene Ontology BP GO:0060249 8.56907537149898e-08 2.90884951860782e-07 1930 1825.18181818182 1464 7.79006882297037e-09 654 1.98087341101427 2.52842824363909 1 12.0186703162052 1927 3259 654 1533 1281 4605 1765 1107 1428 1054 1464 1280 M14536 GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/28 Gene Ontology BP GO:0010829 1.51379489300162e-07 4.55511969423625e-07 930 2147.72727272727 1466 1.37617727014921e-08 424 2.05110245242442 -1.54810174159216 -1 12.0739257211939 3390 424 930 930 1466 4086 3384 3321 1013 1297 3384 1281 M16143 GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. 138/339 Gene Ontology BP GO:0034612 4.70610229482815e-08 1.88691130871218e-07 2590 1756.90909090909 1466 4.27827490499832e-09 433 1.87040431537562 2.60341066378426 1 11.6747714141989 2589 1209 650 1346 1055 3462 3300 433 1524 1466 2292 1282 M15895 GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. 14/31 Gene Ontology BP GO:0050849 1.51013421640045e-08 8.7574463447947e-08 1470 1427.18181818182 1468 1.37284929706035e-09 640 1.44455983932099 1.76957605141216 1 9.46374643343139 1304 962 1596 805 640 2262 1864 1468 1419 1910 1469 1283 M10249 GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT.html The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. 80/195 Gene Ontology BP GO:0061008 1.48848084341355e-08 8.70405107804676e-08 3670 2279.18181818182 1469 1.3531644122585e-09 635 2.24019312393021 -1.89850041970941 -1 14.6817029511294 3670 1029 916 648 635 3136 3948 4533 1244 1469 3843 1284 M10348 GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 4/15 Gene Ontology BP GO:0035589 0.000444254802911416 0.000608638256098467 1235 2022.63636363636 1469 4.44343640956488e-05 1028 2.55643578659635 2.55643578659635 1 7.63082586600864 1235 3257 3570 2544 3347 1334 1469 1247 1150 2068 1028 1285 M12059 GO_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 43/132 Gene Ontology BP GO:0043542 3.61743402239123e-08 1.560942952227e-07 1080 1488 1469 3.28857643806571e-09 799 2.12393577380324 2.09245992749456 1 13.4196618442743 1078 2507 799 970 971 2021 1693 1581 1469 1400 1879 1286 M10616 GO_RESPONSE_TO_PROSTAGLANDIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 19/86 Gene Ontology BP GO:0034695 5.5677198319123e-05 8.48127400904488e-05 700 1650.45454545455 1473 5.0616915852199e-06 700 1.91188544541905 1.91188544541905 1 7.22586071857708 700 2235 1473 1969 2941 1100 981 1314 2836 1589 1017 1287 M14963 GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. 12/24 Gene Ontology BP GO:1903672 4.24515777639141e-06 7.93169720554741e-06 1105 1539.45454545455 1474 3.85924178903898e-07 454 1.84126542485996 2.26364612844359 1 8.71785579464717 1101 2327 1541 1852 2712 1318 1364 454 1474 1603 1188 1288 M10346 GO_LUNG_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_EPITHELIUM_DEVELOPMENT.html The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. 18/43 Gene Ontology BP GO:0060428 1.88376108933214e-09 2.7162430862637e-08 4315 2220 1475 1.71251008267738e-10 45 1.75678739634596 -1.86367292474262 -1 12.3383327794592 4311 958 1086 1206 45 3688 4106 3193 1141 1475 3211 1289 M11194 GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. 24/79 Gene Ontology BP GO:0002792 2.90453226161505e-05 4.64865332322602e-05 355 1577.09090909091 1475 2.64051873561531e-06 355 1.5944530339012 1.58097706088547 1 6.41263847506207 355 1606 1716 2912 2800 544 405 1475 2838 1385 1312 1290 M10051 GO_GLUCURONATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. 7/28 Gene Ontology BP GO:0019585 6.2883689646409e-08 2.30162001994041e-07 2290 1763.27272727273 1476 6.28836914258703e-09 21 3.31279315049711 4.39353459956901 1 20.4126084683146 2288 440 3525 321 1208 3866 3428 870 21 1953 1476 1291 M13375 GO_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that modulates the frequency, rate, or extent of cellular extravasation. 13/37 Gene Ontology BP GO:0002691 6.23926018589682e-05 9.42384028728658e-05 760 1592.54545454545 1476 5.67221558186225e-06 758 2.21025123638882 2.97892936657825 1 8.25961791497081 758 1476 960 1361 2956 1521 969 2043 1703 2306 1465 1292 M11346 GO_APOPTOTIC_CELL_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_CELL_CLEARANCE.html The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. 19/46 Gene Ontology BP GO:0043277 3.46907295174166e-07 8.99827134912655e-07 1375 1524.27272727273 1477 3.15370318069365e-08 1055 1.60201540805701 1.84209072495422 1 8.99067992003486 1371 1239 1149 1700 1718 1809 1055 1477 2491 1219 1539 1293 M14675 GO_URONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. 7/28 Gene Ontology BP GO:0006063 6.2883689646409e-08 2.30162001994041e-07 2290 1831.72727272727 1477 6.28836914258703e-09 22 3.31279315049711 4.39353459956901 1 20.4126084683146 2289 441 4270 322 1209 3867 3429 848 22 1975 1477 1294 M12585 GO_CEREBELLAR_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 34/95 Gene Ontology BP GO:0021695 1.56893342015245e-07 4.69063610416474e-07 4425 2033.63636363636 1478 1.42630321094654e-08 421 2.32073255113249 -1.56026659477322 -1 13.633690250801 4424 1600 719 441 1478 3101 4621 651 421 670 4244 1295 M16159 GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. 29/67 Gene Ontology BP GO:0035306 2.82862817419202e-08 1.31860648722626e-07 985 1508.45454545455 1478 2.57148019141893e-09 881 1.86523443950164 2.33717638930343 1 11.9119737087431 984 2136 1294 1222 881 2383 1378 1478 1682 1538 1617 1296 M11802 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 885/2327 Gene Ontology BP GO:0010628 7.32353609448338e-09 5.83244907147278e-08 1480 1653.72727272727 1479 7.32353611861876e-10 398 1.69657956530039 2.003360967278 1 11.3928090525079 1479 1106 3808 1546 398 3624 1704 969 1949 430 1178 1297 M11435 GO_OXALOACETATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALOACETATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. 7/12 Gene Ontology BP GO:0006107 1.07580573247298e-05 1.85755523089328e-05 1520 1598.36363636364 1480 1.07581094061935e-06 467 1.41231904041745 -1.79835025443804 -1 6.20240667993953 1518 1877 3745 1480 2622 682 752 835 886 2718 467 1298 M12823 GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 29/68 Gene Ontology BP GO:0051898 1.38304636787772e-08 8.32189868277674e-08 990 1503.72727272727 1481 1.25731488779304e-09 607 1.44667990057472 1.71096876675814 1 9.50738748210469 987 1794 1784 935 607 2014 1611 1455 1247 2626 1481 1299 M13305 GO_VACUOLAR_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_ACIDIFICATION.html Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. 9/18 Gene Ontology BP GO:0007035 1.61653454691157e-06 3.38699002766715e-06 1035 1658.27272727273 1485 1.61653572284554e-07 594 1.55302441233757 -1.31150489684051 -1 7.88586819145204 1031 1485 4049 1364 2172 594 1175 1831 1992 1656 892 1300 M16741 GO_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 177/422 Gene Ontology BP GO:0009100 4.64517189935953e-09 4.5728211272053e-08 1565 1437.81818181818 1485 4.22288355378867e-10 205 1.57365872988708 1.95688289544617 1 10.7217295833398 1561 901 1253 1795 205 3279 1485 938 1666 977 1756 1301 M10128 GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. 48/111 Gene Ontology BP GO:0043407 1.61880077268902e-07 4.81183866043222e-07 2010 1571.27272727273 1486 1.47163717436672e-08 478 1.85648171440576 2.12750716930986 1 10.8872463325477 2008 1782 1634 1485 1486 2330 1152 478 832 2683 1414 1302 M10244 GO_REGULATION_OF_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULOGENESIS.html Any process that modulates the frequency, rate or extent of vasculogenesis. 5/21 Gene Ontology BP GO:2001212 0.000104016022667301 0.000152686181866671 1025 1903.72727272727 1490 1.04020891687897e-05 380 1.75503514755647 1.75503514755647 1 6.2170749598433 1025 2535 3559 2472 3180 896 380 1313 2744 1490 1347 1303 M13074 GO_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_B_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. 31/57 Gene Ontology BP GO:0043491 1.00237670960924e-08 6.86435849958067e-08 1010 1444.18181818182 1490 9.11251558342115e-10 482 1.73673460574977 2.03235681271834 1 11.5483994611065 1010 2776 1605 664 482 1876 1316 1490 1389 1637 1641 1304 M11554 GO_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_ENGULFMENT.html The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. 18/159 Gene Ontology BP GO:0006911 3.81784780671915e-05 5.98456021829745e-05 2325 1773.90909090909 1491 3.47083096609185e-06 602 1.81998392223725 2.30067171241047 1 7.13435058566936 2325 1238 1415 1324 2855 2205 2042 1491 602 1102 2914 1305 M15651 GO_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a T cell. 17/50 Gene Ontology BP GO:0002456 1.05507952605336e-07 3.41137481856947e-07 2530 1736.27272727273 1492 9.59163251502761e-09 866 1.93560221219899 2.53507209847064 1 11.6196445734588 2527 1748 1206 1270 1353 3488 2429 905 1492 1815 866 1306 M10222 GO_SULFUR_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 185/421 Gene Ontology BP GO:0006790 1.04408576811391e-08 6.97509384367321e-08 3435 1746.27272727273 1493 9.49168884608162e-10 291 1.55233366472028 -1.31190433733747 -1 10.3122123527888 3434 291 730 1978 508 577 3204 4314 2139 541 1493 1307 M13646 GO_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 265/645 Gene Ontology BP GO:0009314 1.33320404845993e-08 8.16631450791484e-08 1560 1431.54545454545 1493 1.21200368776288e-09 592 1.73444090844663 2.18256204954676 1 11.4117106745182 1559 1506 652 1331 592 3716 1774 721 1493 829 1574 1308 M16115 GO_MITOCHONDRION_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_DISTRIBUTION.html Any process that establishes the spatial arrangement of mitochondria between and within cells. 7/17 Gene Ontology BP GO:0048311 3.63483741680041e-05 5.71330328574756e-05 1795 1692.36363636364 1493 3.63489687236283e-06 224 1.97411031992274 2.39213390668978 1 7.77544258738246 1792 732 4512 1493 2937 2144 1196 776 224 1982 828 1309 M14689 GO_DENDRITIC_SPINE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. 15/39 Gene Ontology BP GO:0097061 3.03168830916189e-09 3.71516474551579e-08 1730 1455.72727272727 1494 2.75608028485426e-10 102 1.6994381301976 1.91576469078488 1 11.7209979006381 1727 1474 1494 407 102 2024 1356 3449 257 2044 1679 1310 M16087 GO_SOMITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITE_DEVELOPMENT.html The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 39/123 Gene Ontology BP GO:0061053 1.56642096028257e-07 4.68614208672162e-07 1665 1675.27272727273 1495 1.42401915619386e-08 814 2.30105768779334 2.57135234605036 1 13.5189948129606 1665 3575 1226 1642 1476 2301 1495 814 1489 1119 1626 1311 M14259 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. 14/47 Gene Ontology BP GO:0010574 4.30992241276955e-07 1.07297424999941e-06 1195 1519 1498 3.91811205191598e-08 822 1.8733409330543 2.22649238459789 1 10.3804795247677 1193 2434 1498 1967 1790 1752 881 822 1730 1417 1225 1312 M12205 GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE.html Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. 12/38 Gene Ontology BP GO:1902668 0.00184845020926674 0.00236885297312323 585 1699.63636363636 1501 0.000168182283184795 584 2.41237139075495 2.57879762365796 1 5.87921057858192 584 2525 1048 1400 3525 1576 1115 2484 1501 1599 1339 1313 M12766 GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION.html The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 82/271 Gene Ontology BP GO:0009952 2.38423768380598e-08 1.16767726004311e-07 805 1668.81818181818 1501 2.16748882695002e-09 801 1.78490259546293 1.91446247119156 1 11.4864184399008 801 3049 1281 2408 827 1501 1163 1665 2867 1212 1583 1314 M13421 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. 79/302 Gene Ontology BP GO:0021953 2.37062206726975e-08 1.16228070309752e-07 1300 1400 1503 2.15511099346775e-09 433 2.05883764603646 2.13561277610742 1 13.253122849086 1298 2382 596 897 826 2060 1618 1503 1631 433 2156 1315 M15104 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION.html The process in which epiblast cells acquire specialized features of neuroepithelial cells. 33/104 Gene Ontology BP GO:0060563 1.68455156937591e-07 4.94397783603815e-07 1675 1308.45454545455 1504 1.53141063487538e-08 206 2.60336871632503 2.74514302660712 1 15.2388963456889 1671 1046 624 206 1504 2564 1955 1358 347 1540 1578 1316 M16080 GO_NEURONAL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ACTION_POTENTIAL.html An action potential that occurs in a neuron. 8/51 Gene Ontology BP GO:0019228 2.26815143532667e-06 4.52363707655572e-06 1125 1727.90909090909 1504 2.26815375035991e-07 120 3.08386586634503 3.08386586634503 1 15.2993398865812 1122 2800 4504 1319 2275 1631 1504 418 120 2151 1163 1317 M11096 GO_ALDEHYDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. 10/18 Gene Ontology BP GO:0046185 2.61361019841953e-06 5.13324541085528e-06 805 1431.81818181818 1507 2.37601209400521e-07 399 1.13199052573544 -1.17896830718372 -1 5.55821580457653 802 861 2313 1689 2287 562 399 1580 1507 2468 1282 1318 M13320 GO_RENAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_WATER_HOMEOSTASIS.html Renal process involved in the maintenance of an internal steady state of water in the body. 19/53 Gene Ontology BP GO:0003091 2.99413808802557e-07 7.92576005855342e-07 790 1410.36363636364 1507 2.72194408683583e-08 196 1.38183747016195 1.57594528974414 1 7.82571825065502 789 196 1507 2072 1683 1078 786 1674 2640 2058 1031 1319 M12774 GO_PIGMENT_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. 26/55 Gene Ontology BP GO:0046148 1.13064685691024e-07 3.60854603675031e-07 1510 1744.27272727273 1508 1.0278608318342e-08 496 1.12982408792156 -1.12632579741976 -1 6.75687203408529 1508 1737 2523 3509 1373 496 936 1006 1900 3240 959 1320 M15242 GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. 13/29 Gene Ontology BP GO:2000178 1.42856837887128e-06 3.03979971727743e-06 1445 1720.90909090909 1508 1.29869936955632e-07 1116 1.25139815222381 1.38583823975672 1 6.4088458451582 1441 1327 2107 1116 2114 1282 1508 1279 2022 2968 1766 1321 M11082 GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC.html The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. 6/32 Gene Ontology BP GO:0007271 3.76563299615057e-07 9.60650219842147e-07 1300 1453.90909090909 1509 3.76563363425035e-08 208 2.66518795777006 3.23882769458941 1 14.8870403566814 1297 1821 3685 753 1778 1509 1194 1752 276 1720 208 1322 M11803 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE.html Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. 30/118 Gene Ontology BP GO:0050885 2.54054580690249e-06 5.00031970387802e-06 1510 1646.18181818182 1509 2.30958976428467e-07 1187 1.72485762478203 1.90782623145163 1 8.48751141490006 1509 1226 1261 1241 2282 1932 1954 1187 1324 1946 2246 1323 M12672 GO_HIPPOCAMPUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPOCAMPUS_DEVELOPMENT.html The progression of the hippocampus over time from its initial formation until its mature state. 46/129 Gene Ontology BP GO:0021766 3.58183368024207e-07 9.24427669670036e-07 1205 1613.27272727273 1509 3.25621296672979e-08 666 2.18011739467606 2.30565021688499 1 12.2113440126974 1202 3390 1737 966 1726 1636 1243 1509 1103 2568 666 1324 M14725 GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to another cell. 128/357 Gene Ontology BP GO:0022409 5.85010235247736e-08 2.19757485619356e-07 2155 1933.36363636364 1509 5.31827500730875e-09 729 1.73854304276014 2.10731666372142 1 10.744891788221 2152 1509 729 1339 1141 4107 2465 1454 2163 847 3361 1325 M15092 GO_PROSTATE_GLAND_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_GROWTH.html The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. 5/17 Gene Ontology BP GO:0060736 8.32333567969858e-06 1.46828448179485e-05 1385 1773.36363636364 1509 8.3233668549255e-07 692 2.50402857340739 -2.50402857340739 -1 11.2342029200686 1382 2297 4350 2129 2575 948 1917 692 763 1509 945 1326 M10586 GO_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING.html A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. 15/30 Gene Ontology BP GO:0016233 6.03325809233275e-05 9.13945100251254e-05 515 1484.72727272727 1510 5.48493050377688e-06 388 1.44925636847322 -1.44925636847322 -1 5.43371413691335 515 1810 2135 2073 3105 388 623 1090 1510 2034 1049 1327 M16320 GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 11/23 Gene Ontology BP GO:0046325 1.71366750501766e-07 5.00412467031257e-07 3560 2083.81818181818 1511 1.5578796713655e-08 426 2.05110245242442 -1.54810174159216 -1 11.996190455554 3558 426 803 882 1511 4271 3159 3241 699 1010 3362 1328 M12576 GO_MACROMOLECULAR_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_REMODELING.html The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. 9/28 Gene Ontology BP GO:0034367 6.51609802789107e-07 1.52899180387048e-06 1515 1912.90909090909 1512 6.51609993857085e-08 834 2.62055146037843 2.31754470985259 1 14.1467269506731 1512 1488 3934 1983 1934 2105 1239 3591 834 1135 1287 1329 M15446 GO_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRINOLYSIS.html A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. 5/29 Gene Ontology BP GO:0042730 1.54168137106788e-07 4.62404819500526e-07 2310 2070.27272727273 1512 1.54168147802305e-08 668 2.7809615396696 3.12236263095527 1 16.3534431821227 2309 1267 4407 1436 1508 3175 3027 1125 668 1512 2339 1330 M11759 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 23/38 Gene Ontology BP GO:1903846 1.73135588855141e-07 5.04625573794363e-07 2475 1899.81818181818 1513 1.5739600225506e-08 175 2.54211646076127 2.61235848586799 1 14.8593698602874 2475 175 631 1196 1513 3561 2779 2988 580 958 4042 1331 M14867 GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). 9/28 Gene Ontology BP GO:0034369 6.51609802789107e-07 1.52899180387048e-06 1515 1947.54545454545 1513 6.51609993857085e-08 835 2.62055146037843 2.31754470985259 1 14.1467269506731 1513 1489 4308 1984 1935 2106 1240 3584 835 1141 1288 1332 M10417 GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 22/54 Gene Ontology BP GO:0000271 9.76016772348909e-08 3.21621424699502e-07 1530 1441.09090909091 1514 8.87288014226644e-09 652 1.72414202479665 2.02281334923442 1 10.3911711889871 1526 1064 1793 1514 1326 2212 1519 1195 652 1546 1505 1333 M13331 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. 23/38 Gene Ontology BP GO:0030511 1.73135588855141e-07 5.04625573794363e-07 2480 1897.54545454545 1514 1.5739600225506e-08 176 2.54211646076127 2.61235848586799 1 14.8593698602874 2476 176 632 1197 1514 3562 2780 2952 581 960 4043 1334 M16168 GO_PROTEIN_LIPID_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_REMODELING.html The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. 9/28 Gene Ontology BP GO:0034368 6.51609802789107e-07 1.52899180387048e-06 1515 1967.27272727273 1514 6.51609993857085e-08 836 2.62055146037843 2.31754470985259 1 14.1467269506731 1514 1490 4521 1985 1936 2107 1241 3575 836 1146 1289 1335 M16494 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 12/42 Gene Ontology BP GO:0003071 1.53339313348067e-07 4.60513862791122e-07 2995 2356.09090909091 1515 1.39399385487064e-08 900 2.01522634395861 2.1197802647682 1 11.8538667186279 2991 1478 1324 1515 1471 3881 3284 4408 900 1185 3480 1336 M14082 GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 14/44 Gene Ontology BP GO:0044058 3.35089942814003e-06 6.40656842614426e-06 635 1614.90909090909 1516 3.0462768472971e-07 267 2.80124700090679 2.80124700090679 1 13.5042411293867 632 3347 1516 2319 3492 432 484 679 1554 3042 267 1337 M15240 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. 10/24 Gene Ontology BP GO:0061081 1.11948696844826e-05 1.92439022380795e-05 1670 1759.18181818182 1516 1.01772060462239e-06 657 3.42259791407376 4.2605636415392 1 14.9820698640493 1670 3528 1391 932 2611 1971 1110 1473 657 2492 1516 1338 M12295 GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. 49/122 Gene Ontology BP GO:0032091 4.89835214465092e-07 1.19574390155701e-06 1465 1637.09090909091 1517 4.45304839570999e-08 231 1.56037082908397 2.17939483206609 1 8.57811554067437 1461 1368 1517 988 1915 3251 1683 231 1999 2777 818 1339 M13125 GO_MIDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). 68/187 Gene Ontology BP GO:0030901 3.69281257433694e-08 1.58221668131212e-07 1610 1629.81818181818 1518 3.357102396657e-09 568 2.01920205356755 2.34590354234114 1 12.7469037229638 1610 1518 812 880 978 3374 2251 2576 1044 568 2317 1340 M15311 GO_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 44/99 Gene Ontology BP GO:0006637 1.91231994475964e-08 1.01126440814567e-07 630 1498.09090909091 1518 1.73847269216565e-09 19 1.24623502667348 -1.05534535932076 -1 8.09217381024459 629 1526 2446 3321 730 19 165 1518 2650 3378 97 1341 M11722 GO_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. 196/485 Gene Ontology BP GO:0016055 6.72466507336554e-07 1.56976470264637e-06 1155 1719.90909090909 1520 6.11333375351989e-08 413 1.73442562235438 2.05895312654643 1 9.3446834954389 1152 2647 1830 1520 1913 3099 1489 413 1335 2325 1196 1342 M11799 GO_LIPID_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. 8/42 Gene Ontology BP GO:0044241 2.78343814624308e-09 3.58986203139073e-08 1715 1717.63636363636 1521 2.78343814972947e-10 105 3.21853417930541 -2.84846552517599 -1 22.2426961904033 1712 981 3806 870 105 2432 1343 3500 953 1521 1671 1343 M12687 GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE.html The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. 6/60 Gene Ontology BP GO:0050912 1.04829813325371e-07 3.39181061511985e-07 1525 1736.18181818182 1521 1.04829818270552e-08 93 1.61242496661143 1.82242171104287 1 9.68331269486502 1521 2203 3950 2192 1379 1374 861 648 3152 1725 93 1344 M13574 GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 39/111 Gene Ontology BP GO:0051588 1.77382438503137e-07 5.14741663731291e-07 840 1608.45454545455 1522 1.61256775277453e-08 836 1.7496026523684 1.84426301823821 1 10.2129089116507 836 2219 1763 3105 1522 1007 859 1275 2190 1701 1216 1345 M11975 GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. 203/495 Gene Ontology BP GO:0043623 5.74310709207197e-08 2.17320670158844e-07 1715 1569.54545454545 1523 5.22100658363271e-09 466 1.50507458854467 -1.2210616103226 -1 9.30872892691901 1715 899 2394 1416 1131 466 1458 1676 1699 2888 1523 1346 M11296 GO_INORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSPORT.html The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 33/147 Gene Ontology BP GO:0015698 2.88021999662564e-09 3.65029676110884e-08 1525 1373.18181818182 1524 2.61838181854218e-10 93 1.74627724313555 1.90380459241531 1 12.0564470019872 1524 1376 1367 1980 93 1831 1034 1810 1636 1539 915 1347 M14016 GO_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MATURATION.html Any process that modulates the frequency, rate or extent of protein maturation. 42/138 Gene Ontology BP GO:1903317 1.48673065345372e-05 2.49742779449553e-05 1210 1729.27272727273 1524 1.3515824551602e-06 978 1.7023021431511 1.87026791629018 1 7.2727764634704 1207 2418 1524 2720 2675 1253 1313 978 1777 1368 1789 1348 M11634 GO_THIOESTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 44/99 Gene Ontology BP GO:0035383 1.91231994475964e-08 1.01126440814567e-07 630 1512.18181818182 1525 1.73847269216565e-09 18 1.24623502667348 -1.05534535932076 -1 8.09217381024459 628 1525 2445 3320 729 18 164 1683 2649 3377 96 1349 M14824 GO_HEART_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_FORMATION.html The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. 7/21 Gene Ontology BP GO:0060347 1.64822137777262e-07 4.87432602356579e-07 1220 1816 1526 1.64822150002115e-08 399 1.73709424355244 2.359932438205 1 10.178068807095 1218 2195 4298 2639 1526 933 437 399 1969 3572 790 1350 M14531 GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. 8/25 Gene Ontology BP GO:0035590 5.9800939915436e-06 1.08660151328416e-05 735 1795.36363636364 1527 5.98011008429042e-07 369 2.0865234618148 2.0865234618148 1 9.61430792162383 733 2838 4248 2814 2494 723 369 1262 1990 1527 751 1351 M16135 GO_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOCLAST_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. 29/50 Gene Ontology BP GO:0030316 1.81689882350601e-07 5.25271558999902e-07 835 1556.27272727273 1527 1.65172633959727e-08 832 1.67519974751353 1.92102580692746 1 9.76492309414153 1043 3235 1847 1715 1527 1121 835 1839 1272 1853 832 1352 M10135 GO_METANEPHRIC_NEPHRON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. 10/29 Gene Ontology BP GO:0072273 1.82481593908164e-07 5.27226512334795e-07 3560 1954.45454545455 1528 1.6589237185847e-08 195 2.10192590002304 -1.77288352792128 -1 12.2492088325647 3556 428 833 222 1528 4140 2670 3552 195 860 3515 1353 M12386 GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION.html Any process that activates or increases the frequency, rate or extent of vasoconstriction. 16/45 Gene Ontology BP GO:0045907 6.76807112588252e-07 1.57764796139145e-06 765 1419.09090909091 1528 6.15279382546373e-08 627 2.1728288490649 2.18349591934585 1 11.7023106288893 765 2057 1472 1528 1917 1804 1639 898 627 912 1991 1354 M12688 GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. 4/16 Gene Ontology BP GO:2001053 1.21305709809152e-06 2.63557515509542e-06 1785 1766.27272727273 1528 1.21305776027041e-07 16 2.56184997528629 3.31251405256089 1 13.2674936767273 1785 1194 3951 229 2099 2897 3010 1487 16 1233 1528 1355 M15520 GO_RESPONSE_TO_ACIDIC_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACIDIC_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. 7/28 Gene Ontology BP GO:0010447 3.02722984927912e-06 5.85642841258456e-06 1095 1686.27272727273 1528 3.02723397314128e-07 414 1.61671985597021 1.77529113663348 1 7.85239457757497 1094 1572 4417 1952 2864 956 864 414 1528 1979 909 1356 M16286 GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. 40/98 Gene Ontology BP GO:0003143 5.68817208267463e-08 2.15417479444195e-07 2690 1951.54545454545 1528 5.17106566340381e-09 537 1.87634928401259 2.31470893587795 1 11.6116777458675 2688 1528 1190 537 1128 4395 3179 1590 1356 1459 2417 1357 M14830 GO_CELLULAR_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a cell. 8/16 Gene Ontology BP GO:0009992 1.10049243630131e-06 2.41816676845575e-06 1665 1809.45454545455 1529 1.10049298128931e-07 162 2.82905274286634 2.48607594904051 1 14.7494901096835 1661 869 4300 1354 2496 1400 450 3694 1989 1529 162 1358 M14213 GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 54/160 Gene Ontology BP GO:0042035 2.67503442512184e-08 1.26478460650109e-07 3745 1918.09090909091 1530 2.43184950695295e-09 514 1.57929484123218 -1.6854922861584 -1 10.1124059839104 3744 514 1424 1530 864 2440 4159 1306 1965 940 2213 1359 M10254 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 52/124 Gene Ontology BP GO:1903845 6.98752136708107e-09 5.62271433403075e-08 1260 1659.72727272727 1532 6.35229217206768e-10 348 1.79374439281521 2.08076424369859 1 12.0717694214763 1256 2613 1842 660 348 2877 2306 774 1421 2628 1532 1360 M15113 GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. 52/124 Gene Ontology BP GO:0030512 6.98752136708107e-09 5.62271433403075e-08 1260 1663.72727272727 1533 6.35229217206768e-10 349 1.79374439281521 2.08076424369859 1 12.0717694214763 1257 2614 1843 661 349 2878 2307 807 1422 2630 1533 1361 M14245 GO_SMALL_MOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. 178/427 Gene Ontology BP GO:0044282 1.6186760617626e-08 9.07613404640033e-08 1670 1644.81818181818 1534 1.47152370333836e-09 570 1.54743713029365 -1.34696016824046 -1 10.1154283731315 1668 1275 1119 2716 675 570 2398 1524 2284 2330 1534 1362 M10933 GO_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. 65/161 Gene Ontology BP GO:0010469 6.44193788687322e-09 5.42829720667012e-08 3005 1891.27272727273 1536 5.85630718703289e-10 111 1.56544922261881 -1.2548588293613 -1 10.5575669924284 3003 111 1246 565 314 4450 3124 1536 1140 1802 3513 1363 M11861 GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 29/115 Gene Ontology BP GO:0033555 4.94529824807377e-05 7.60298667741938e-05 990 1656.09090909091 1536 4.49582674099443e-06 643 2.47489097379039 2.12648017316919 1 9.46277817147532 988 1536 643 1555 2914 2004 1413 3104 1282 1208 1570 1364 M14556 GO_DIENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. 27/125 Gene Ontology BP GO:0021536 8.48282756171113e-09 6.24180164326859e-08 4475 2274.63636363636 1538 7.71166144947226e-10 403 2.05607949684266 -1.64556417765043 -1 13.7506851869906 4471 1538 958 403 419 3303 4392 3350 1235 1347 3605 1365 M16808 GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase A. 9/16 Gene Ontology BP GO:0034199 1.827652058246e-06 3.75477367541425e-06 375 1471 1538 1.82765356138816e-07 157 1.31074956405595 1.31074956405595 1 6.60118514169105 373 436 4620 1693 2215 424 157 1538 2407 1672 646 1366 M13075 GO_SOMITOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITOGENESIS.html The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 32/100 Gene Ontology BP GO:0001756 6.77230379400193e-08 2.42434899888597e-07 2250 1975.36363636364 1540 6.15664000225009e-09 1102 2.33106602782567 2.52512049477703 1 14.3146304039138 2250 3718 1384 1499 1196 3291 2024 1102 1540 1429 2296 1367 M13536 GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. 26/46 Gene Ontology BP GO:0070830 1.5668148343415e-06 3.29816659996213e-06 1990 1537.36363636364 1540 1.42437813655474e-07 801 1.81818088699831 -1.87459218132801 -1 9.25174504900656 1988 1540 1018 1991 2131 858 2551 937 1520 1576 801 1368 M10583 GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 2/13 Gene Ontology BP GO:0010455 7.19980928210573e-07 1.66560610347867e-06 1435 1637.4 1541.5 7.99979065109414e-08 139 2.99663793497044 -2.99663793497044 -1 16.0735976590086 1431 2541 3608 NA 2789 835 610 1652 193 2576 139 1369 M10819 GO_ACTIN_MYOSIN_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MYOSIN_FILAMENT_SLIDING.html The sliding movement of actin thin filaments and myosin thick filaments past each other. 26/58 Gene Ontology BP GO:0033275 2.8932430861152e-09 3.65029676110884e-08 1125 1664.27272727273 1542 2.63022099083649e-10 270 3.21543093716906 3.72887360889522 1 22.199609560535 1124 2224 270 1350 1542 3023 2502 2433 984 455 2400 1370 M11343 GO_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_ARREST.html A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). 85/219 Gene Ontology BP GO:0007050 3.54615059363226e-08 1.53876422488174e-07 1395 1678.09090909091 1542 3.223773318902e-09 964 1.4642961062314 1.55455397923422 1 9.26030859867615 1260 1720 2284 2044 964 2064 1395 1458 2334 1542 1394 1371 M11329 GO_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 516/1254 Gene Ontology BP GO:0051338 8.67537852246871e-09 6.33329913204752e-08 1545 1711.81818181818 1543 8.67537855633668e-10 466 1.66396082969357 1.98004348234105 1 11.1185050763713 1543 1768 3731 787 466 3568 1632 1112 2023 1070 1130 1372 M14866 GO_MUSCLE_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FILAMENT_SLIDING.html The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. 26/58 Gene Ontology BP GO:0030049 2.8932430861152e-09 3.65029676110884e-08 1125 1665.36363636364 1543 2.63022099083649e-10 271 3.21543093716906 3.72887360889522 1 22.199609560535 1125 2225 271 1351 1543 3024 2503 2431 985 460 2401 1373 M10187 GO_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. 57/182 Gene Ontology BP GO:0006694 1.33772853092101e-08 8.17688989097228e-08 3720 1896.18181818182 1544 1.21611685368652e-09 594 1.73319360280686 -1.73824514798784 -1 11.4025998060325 3717 1036 1544 1472 594 1728 3597 1447 1366 1820 2537 1374 M14476 GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a cardiac muscle cell. 24/74 Gene Ontology BP GO:0086001 5.91728011646463e-07 1.40682090357639e-06 1115 1304 1544 5.37934700729088e-08 315 2.57119866313128 2.71045434007502 1 13.9666214941397 1111 1605 398 315 1878 1691 1544 3296 426 381 1699 1375 M14957 GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM.html The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. 18/51 Gene Ontology BP GO:0001738 5.90224769867891e-08 2.21001097298114e-07 1995 1557.45454545455 1544 5.36567987002434e-09 186 1.91024594831458 2.46423007385335 1 11.8017388004714 1994 836 1538 891 1146 3154 1747 1544 186 2418 1678 1376 M11224 GO_CEREBELLAR_CORTEX_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 21/57 Gene Ontology BP GO:0021696 1.55212430271259e-07 4.64936331451263e-07 4120 2090.63636363636 1545 1.41102219292426e-08 354 2.15307244767659 -1.73920120897626 -1 12.6564026243941 4118 1545 966 482 1474 3574 4478 2337 354 625 3044 1377 M12495 GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 916/2298 Gene Ontology BP GO:0044093 3.85975117584665e-09 4.15796396971137e-08 1545 1790 1545 3.8597511825506e-10 185 1.57880444551349 1.87810016248068 1 10.8173205211119 1545 449 3918 1264 185 4236 1991 1511 2026 394 2171 1378 M15925 GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. 12/30 Gene Ontology BP GO:1902170 0.000578421932208868 0.000780928476663499 1210 2003.54545454545 1545 5.25976423964658e-05 596 2.41172786120443 2.41172786120443 1 6.95653569326766 1206 3248 1247 2650 3584 1050 596 1545 3481 2188 1244 1379 M13786 GO_REGULATION_OF_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. 19/38 Gene Ontology BP GO:0030823 7.22770573341844e-07 1.67122697810069e-06 1770 1412.18181818182 1546 6.57064373450249e-08 507 1.95398252067935 2.1286957038031 1 10.4782682311735 1768 1608 712 727 1939 2285 1365 985 1546 507 2092 1380 M14311 GO_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PIGMENTATION.html The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. 22/53 Gene Ontology BP GO:0048066 1.27016108081443e-07 3.9420841565651e-07 4485 2206.36363636364 1548 1.15469195831515e-08 159 1.9837453839932 -1.70935856303097 -1 11.7930183897071 4483 177 1101 756 1414 3466 3623 3877 159 1548 3666 1381 M12976 GO_REGULATION_OF_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METAL_ION_TRANSPORT.html Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 174/505 Gene Ontology BP GO:0010959 1.17344837080934e-08 7.5149252216107e-08 1000 1393.90909090909 1549 1.06677125188031e-09 200 1.62430808704653 1.74733206709735 1 10.7415274844544 1000 619 500 1549 547 1967 1763 2814 2355 200 2019 1382 M16739 GO_METANEPHROS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_MORPHOGENESIS.html The process in which the anatomical structures of the metanephros are generated and organized. 13/38 Gene Ontology BP GO:0003338 1.88390324174065e-07 5.38937939088222e-07 290 2159.81818181818 1549 1.71263945733001e-08 286 2.23863772737654 -2.08477329157795 -1 13.0260847377542 3931 848 718 289 1549 4611 2693 3335 286 900 4598 1383 M14873 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. 20/43 Gene Ontology BP GO:0048873 3.09591213849879e-05 4.93454172984891e-05 1350 1788.63636363636 1551 2.81450518731627e-06 194 1.25728674985269 1.55124801226499 1 5.02635832398718 1350 194 2442 1229 2817 2102 1503 1444 2402 2641 1551 1384 M16522 GO_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. 101/270 Gene Ontology BP GO:0042594 1.85242270416977e-09 2.70421771353233e-08 1780 1677.18181818182 1551 1.68402064157229e-10 40 1.72588645449395 1.97543401697571 1 12.1243953204963 1780 1353 1087 1333 40 3904 2184 1266 1551 2378 1573 1385 M13403 GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 15/38 Gene Ontology BP GO:0045662 3.8547187852572e-08 1.62788522131635e-07 3075 2130.63636363636 1553 3.50428986617951e-09 414 1.7168229815433 2.17646401830437 1 10.8183382378566 3074 414 1005 1553 996 4433 3947 3137 865 805 3208 1386 M10667 GO_MEMBRANE_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. 16/45 Gene Ontology BP GO:0044091 1.01606524914134e-07 3.31524311438036e-07 2755 1832.72727272727 1559 9.23695723698275e-09 142 1.59433651902663 1.77480266826769 1 9.58935927409184 2754 198 1559 800 1339 3665 3354 1743 142 1259 3347 1387 M10567 GO_RESPONSE_TO_AMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. 30/77 Gene Ontology BP GO:0014075 1.72371662676181e-08 9.43775506846116e-08 1760 1409.72727272727 1561 1.56701512751569e-09 457 2.35214914327679 2.41569428874112 1 15.338695911107 1758 1730 990 602 693 2597 1561 2069 457 1583 1467 1388 M12448 GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 12/29 Gene Ontology BP GO:0060099 0.00181251481638971 0.00232601058388542 1035 1816.18181818182 1561 0.000164909983481034 767 2.21146479003281 2.19982963370998 1 5.40585084695246 1035 1561 767 1483 3653 1881 1224 2494 2656 1174 2050 1389 M10129 GO_SYNAPTIC_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_LOCALIZATION.html Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. 57/155 Gene Ontology BP GO:0097479 1.94507390252274e-07 5.52691439988559e-07 3120 2311.90909090909 1562 1.76824915862864e-08 928 1.60134607334869 1.96667154593846 1 9.30157277314305 3119 1219 1557 1310 1562 4448 3806 2406 1129 928 3947 1390 M13469 GO_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 21/70 Gene Ontology BP GO:0048708 1.91033752647122e-06 3.8970549804068e-06 2645 1890.63636363636 1562 1.73667198662421e-07 698 1.78335301181384 2.52488629099766 1 8.9545669303256 2644 1309 1562 698 2195 4195 3136 979 779 1067 2233 1391 M14156 GO_DRUG_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_METABOLIC_PROCESS.html The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. 15/89 Gene Ontology BP GO:0017144 4.36638681875892e-08 1.79403662030111e-07 1620 1506.63636363636 1562 3.96944264129048e-09 627 2.33020367052084 2.48645650098532 1 14.5921812451393 1617 1321 636 627 1024 2661 2233 2264 948 1562 1680 1392 M15230 GO_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that modulates the frequency, rate or extent of membrane invagination. 12/29 Gene Ontology BP GO:1905153 0.00181251481638971 0.00232601058388542 1040 1817.45454545455 1562 0.000164909983481034 768 2.21146479003281 2.19982963370998 1 5.40585084695246 1036 1562 768 1484 3654 1882 1225 2492 2657 1181 2051 1393 M11391 GO_POSITIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BEHAVIOR.html Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 9/31 Gene Ontology BP GO:0048520 0.000383527333632503 0.000528873599660146 1060 2014.72727272727 1563 3.83593541662081e-05 549 2.38651247616107 2.38651247616107 1 7.25876343627442 1059 3457 3735 2325 3508 1103 549 1563 974 2337 1552 1394 M16838 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 17/39 Gene Ontology BP GO:0045922 8.85548100750213e-09 6.42437473716131e-08 1765 1408.81818181818 1566 8.05043731195218e-10 171 1.75126744547194 2.22525085769733 1 11.6918033242455 1761 1156 1732 288 434 3336 1970 1566 171 1819 1264 1395 M10768 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 27/104 Gene Ontology BP GO:0035725 1.95768450382054e-07 5.54577739550869e-07 3945 2482.18181818182 1567 1.77971334366037e-08 963 1.92536252287987 1.90537298136597 1 11.1810089808312 3943 1457 963 976 1567 3901 3422 3580 1537 1344 4614 1396 M12982 GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. 17/32 Gene Ontology BP GO:0090049 1.86973350421072e-06 3.82262116250567e-06 1570 1492.72727272727 1567 1.69975917569055e-07 508 1.78137718475229 1.86932843627592 1 8.95849509140296 832 3179 1873 1567 2192 941 763 508 1569 2251 745 1397 M13898 GO_NEGATIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEATH.html Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 527/1365 Gene Ontology BP GO:0060548 4.65590181735311e-09 4.5728211272053e-08 1420 1577.18181818182 1567 4.65590182710794e-10 229 1.76056708588734 1.98183989919088 1 11.9951828740362 1418 604 4152 765 240 3082 1699 1567 1767 229 1826 1398 M12124 GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. 18/40 Gene Ontology BP GO:0060674 6.63042901834166e-07 1.55313778951612e-06 1350 1792.45454545455 1568 6.02766456058363e-08 1312 1.09099854200428 1.28346282935591 1 5.88273079227318 1349 1312 2285 1562 1907 2045 1468 1568 1852 2988 1381 1399 M11876 GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 14/42 Gene Ontology BP GO:0060079 1.02354426973824e-06 2.26300764018794e-06 970 1434.81818181818 1570 9.30495223581691e-08 546 2.2041745796033 2.10909938845748 1 11.5505649208996 968 967 1570 1600 2028 1897 1151 2018 546 1414 1624 1400 M15641 GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 81/250 Gene Ontology BP GO:0050777 1.99138404580949e-07 5.63093552051978e-07 1570 1830.18181818182 1570 1.81034929642231e-08 637 2.03372470664389 2.42532612434048 1 11.7977984853945 2082 1662 658 1568 1570 3862 2560 1374 1152 637 3007 1401 M13915 GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT.html Any apoptotic process that is involved in anatomical structure development. 16/38 Gene Ontology BP GO:1902742 2.99909308817147e-06 5.81584093547142e-06 990 1690.54545454545 1571 2.72645197874122e-07 252 1.60456601979595 1.76764619529842 1 7.79786211965985 989 3481 2048 1571 3674 898 346 557 2083 2697 252 1402 M16481 GO_DEVELOPMENTAL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. 114/357 Gene Ontology BP GO:0021700 1.88013438240766e-07 5.38523376774754e-07 1050 1592.18181818182 1571 1.70921322098654e-08 604 1.72518249254004 1.85854126162009 1 10.0389496027958 1047 2415 604 1779 1547 1571 1322 2360 2550 632 1687 1403 M10345 GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. 26/73 Gene Ontology BP GO:0046470 1.03785366336064e-07 3.36505206632923e-07 4390 2301.27272727273 1573 9.43503374837787e-09 474 2.11937844201246 -1.95414071430543 -1 12.7345559458377 4386 1381 1111 1467 1347 3098 4514 1999 474 1573 3964 1404 M16307 GO_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS.html An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. 100/443 Gene Ontology BP GO:0006909 1.94717164692647e-07 5.52949110500282e-07 1255 1677.63636363636 1573 1.77015619933307e-08 931 1.90743268687888 2.40247437405474 1 11.0791479504143 1255 1771 931 1812 1563 2455 1314 1641 1573 1439 2700 1405 M11306 GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. 13/24 Gene Ontology BP GO:0060644 9.38652206896472e-08 3.11297299758594e-07 1115 1555.54545454545 1574 8.5332022449547e-09 464 1.55387578290433 1.20283180510836 1 9.38543776233406 1114 1618 1574 2133 1315 654 464 3323 2287 1779 850 1406 M11652 GO_BONE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_GROWTH.html The increase in size or mass of a bone that contributes to the shaping of that bone. 6/26 Gene Ontology BP GO:0098868 1.98683959900949e-05 3.26660632372559e-05 1100 1704.54545454545 1574 1.98685736312519e-06 624 1.81521316764099 1.81521316764099 1 7.55869221992461 1100 1574 3783 2241 2749 913 624 2028 1820 1076 842 1407 M12094 GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 26/59 Gene Ontology BP GO:0051281 2.7465962656712e-09 3.570072991388e-08 4555 2125.45454545455 1575 2.496905699182e-10 78 1.74061637259231 -1.36825235746095 -1 12.0329575266437 4555 546 1520 1111 78 2704 4313 1181 1722 1575 4075 1408 M11430 GO_RESPONSE_TO_AXON_INJURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AXON_INJURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. 36/74 Gene Ontology BP GO:0048678 1.64482168474995e-06 3.43849936168123e-06 1580 1575.36363636364 1578 1.49529355863269e-07 841 2.23120293638075 2.48171582428505 1 11.315912271679 1578 1948 957 851 2148 2892 1712 2070 898 1434 841 1409 M15313 GO_SCHWANN_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 20/42 Gene Ontology BP GO:0014037 2.01841104628186e-07 5.68313067791795e-07 645 1692.63636363636 1578 1.83491930132995e-08 643 1.27305888193559 1.43224074210677 1 7.38038027966551 643 2726 2472 2837 1578 889 1010 734 2912 1713 1105 1410 M10148 GO_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_FIBER_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. 13/22 Gene Ontology BP GO:0043149 6.84681255257087e-05 0.000102713249375078 1335 1897.45454545455 1580 6.22456877045605e-06 720 1.64870124813021 1.86195732969951 1 6.10389311204487 1334 2928 2238 2135 2972 1580 1474 1131 720 2951 1409 1411 M11075 GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. 13/22 Gene Ontology BP GO:0030038 6.84681255257087e-05 0.000102713249375078 1335 1905.18181818182 1581 6.22456877045605e-06 721 1.64870124813021 1.86195732969951 1 6.10389311204487 1335 2929 2239 2136 2973 1581 1475 1205 721 2953 1410 1412 M14800 GO_HISTONE_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). 7/14 Gene Ontology BP GO:0071044 3.71652762590056e-06 7.0431990885944e-06 1125 1762.18181818182 1581 3.71653384157511e-07 392 0.763677827729883 -0.763677827729883 -1 3.65236813160053 1123 1632 4294 2438 2392 392 527 658 1581 3571 776 1413 M14324 GO_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. 212/578 Gene Ontology BP GO:0022407 4.06975150130022e-08 1.69621689591893e-07 1400 1635.72727272727 1584 3.69977416053274e-09 333 1.85501468033989 2.11400199043464 1 11.6583857769204 1399 1584 333 1063 1210 3379 2174 1916 1675 484 2776 1414 M14525 GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. 27/57 Gene Ontology BP GO:0048635 2.05860932007051e-07 5.78228861045817e-07 2850 1977.63636363636 1584 1.87146319336463e-08 802 1.82024016223459 -1.16094560173247 -1 10.5398941903946 2847 1379 1211 862 1584 4613 2874 1599 802 1346 2637 1415 M11053 GO_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 189/412 Gene Ontology BP GO:0051186 1.92400406887339e-08 1.01450865252488e-07 970 1939.54545454545 1585 1.74909462336338e-09 250 1.21229812212907 -0.99205657721937 -1 7.8702460472963 969 1585 2975 3382 731 250 1288 2448 2672 3832 1203 1416 M14610 GO_REGULATION_OF_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROVILLUS_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. 11/32 Gene Ontology BP GO:0032530 7.39234869454062e-07 1.70335856023584e-06 2650 1685.18181818182 1585 6.72031925317101e-08 744 1.74568327985261 -1.88464053991384 -1 9.34785746407161 2649 1332 1364 1586 1946 1585 2867 744 1207 1452 1805 1417 M16078 GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of B cell activation. 34/210 Gene Ontology BP GO:0050871 2.07467840432418e-07 5.82038177116446e-07 3475 2074.90909090909 1586 1.88607145452162e-08 673 1.72150371783998 -1.39240402182983 -1 9.96361496621718 3471 1043 1398 1377 1586 1486 3191 4236 1626 673 2737 1418 M12283 GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that activates or increases the activity of an enzyme. 766/1913 Gene Ontology BP GO:0043085 4.9206963713897e-09 4.70279390287928e-08 1590 1697.81818181818 1587 4.92069638228565e-10 6 1.62120633488836 1.91881034787558 1 11.0273660543882 1587 6 3882 907 257 4174 1890 1508 1897 314 2254 1419 M12206 GO_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_FORMATION.html The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. 17/47 Gene Ontology BP GO:0048645 2.07649895805251e-07 5.82197141439482e-07 2915 2079 1588 1.88772650367784e-08 723 2.29868038318922 -1.6081560041201 -1 13.3039101267516 2911 840 723 780 1588 3821 2919 2734 1350 991 4212 1420 M12822 GO_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 107/316 Gene Ontology BP GO:1901654 5.88566761652092e-08 2.20828070401936e-07 1590 1818.81818181818 1590 5.35060706725489e-09 362 1.93507495638897 1.95321380250989 1 11.9557465247917 1590 768 362 1218 1143 3381 2056 3487 2519 556 2927 1421 M13497 GO_PROTEIN_ADP_RIBOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ADP_RIBOSYLATION.html The transfer, from NAD, of ADP-ribose to protein amino acids. 12/22 Gene Ontology BP GO:0006471 4.02140121797313e-07 1.01474814429616e-06 2625 1653.63636363636 1590 3.6558199573174e-08 225 1.45563723855677 -0.5475779367066 -1 8.09865816639961 2624 225 1896 1027 1768 3382 1590 1334 325 2805 1214 1422 M14486 GO_RESPONSE_TO_MUSCLE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. 19/61 Gene Ontology BP GO:0014850 1.13331266973849e-09 1.85935361328473e-08 2760 2118.36363636364 1590 1.03028424574755e-10 11 1.73544131156586 1.90805956249261 1 12.4535854278933 2756 956 1423 825 11 4135 3410 3725 1590 1221 3250 1423 M15419 GO_HYDROGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_TRANSPORT.html The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 63/157 Gene Ontology BP GO:0006818 6.48461941434103e-06 1.16698015274362e-05 1390 1971.81818181818 1590 5.89512593471602e-07 266 1.01712677427073 -0.777719710246416 -1 4.65746647468807 1390 1590 3265 2558 2492 266 920 1317 3199 3886 807 1424 M16430 GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. 41/80 Gene Ontology BP GO:0043525 9.8973022149748e-07 2.20187705721744e-06 935 1752.81818181818 1590 8.99755151595446e-08 658 1.92175303418727 2.36986282340435 1 10.0918032264556 934 3886 1806 2258 2014 1590 658 811 1502 2866 956 1425 M12500 GO_LYMPHOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. 200/544 Gene Ontology BP GO:0046649 2.64152070887848e-08 1.25141295963921e-07 2100 1786.36363636364 1592 2.40138249144998e-09 587 1.8161472452007 2.26491352527992 1 11.6367808961479 2098 1005 678 587 862 4556 2631 1794 1592 1303 2544 1426 M12452 GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. 47/109 Gene Ontology BP GO:0035050 1.12165689426738e-07 3.58667559234396e-07 2305 1974 1593 1.0196881376858e-08 927 1.89177267492198 2.3014984609155 1 11.3183143507697 2304 1593 1292 927 1371 4371 2815 1556 1589 1703 2193 1427 M13060 GO_SUBSTANTIA_NIGRA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTANTIA_NIGRA_DEVELOPMENT.html The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). 44/111 Gene Ontology BP GO:0021762 8.11988600308724e-08 2.77823365603051e-07 4115 2500.72727272727 1594 7.38171482070969e-09 980 2.06005390973593 -1.69504635411821 -1 12.5372412551009 4115 1594 1081 1365 1271 3534 4574 3798 980 982 4214 1428 M15639 GO_CELLULAR_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 11/29 Gene Ontology BP GO:0071305 0.0001184354496283 0.000172464863200599 660 1950.36363636364 1598 1.0767438727077e-05 660 1.71583058016901 1.71583058016901 1 5.99393872838104 660 2562 1586 3326 3057 903 867 1598 3673 2025 1197 1429 M10923 GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. 15/56 Gene Ontology BP GO:0045762 3.40253694047136e-06 6.48521306018412e-06 1425 1685.27272727273 1599 3.09322018442963e-07 1122 1.98438220929996 1.81399441602079 1 9.55654185814402 1424 1749 1348 1599 2354 1858 1185 3059 1629 1122 1211 1430 M13372 GO_PHOSPHATE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSPORT.html The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/20 Gene Ontology BP GO:0006817 3.03059557846e-08 1.3822254686434e-07 1220 1882.54545454545 1599 3.03059561979028e-09 70 1.70104608789579 1.70104608789579 1 10.8311028581546 1219 2904 4062 1913 2216 1372 939 70 1599 3277 1137 1431 M14609 GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 12/29 Gene Ontology BP GO:0010888 8.08603371608421e-05 0.000120408770185308 1320 1914.27272727273 1602 7.35120993737362e-06 934 1.89795499676455 1.95857260157503 1 6.90507162817809 1319 2758 1585 2835 2994 1389 934 1469 2230 1602 1942 1432 M14157 GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 334/883 Gene Ontology BP GO:0071345 1.78439143325333e-08 9.71269569120191e-08 1445 1543.36363636364 1603 1.62217404338754e-09 552 1.74579010568243 2.10994324221806 1 11.3643332068876 1445 1829 552 1603 701 3520 1812 825 2024 1032 1634 1433 M15028 GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of B cell differentiation. 12/26 Gene Ontology BP GO:0045579 3.37344148016993e-06 6.43768548805137e-06 630 1417.63636363636 1604 3.06676968450649e-07 189 1.65635062643458 -1.65635062643458 -1 7.98169347242528 627 1862 2056 2729 2351 189 252 439 2885 1604 600 1434 M16724 GO_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_SELECTION.html The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. 21/47 Gene Ontology BP GO:0045058 2.3634000244819e-08 1.16228070309752e-07 1605 1665 1604 2.14854549988296e-09 823 1.74738641289978 1.95374585374747 1 11.2482530014299 1604 1803 1576 1033 823 3018 2399 857 1144 1835 2223 1435 M15213 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that activates or increases the rate or extent of osteoblast proliferation. 12/22 Gene Ontology BP GO:0033690 4.36418002568125e-07 1.08531804280868e-06 705 1627.09090909091 1605 3.96743717401075e-08 533 1.45182735482922 1.36460447387449 1 8.0381109613932 705 2890 2088 2580 1793 657 533 989 3188 1605 870 1436 M14628 GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that modulates the frequency, rate or extent of lamellipodium organization. 34/81 Gene Ontology BP GO:1902743 2.21505214014611e-06 4.4310586327869e-06 2245 1599.72727272727 1606 2.0136857912332e-07 840 1.80502791980832 1.96309574265597 1 8.96995480988397 1156 2135 1606 936 2244 1740 840 1482 1138 2244 2076 1437 M15376 GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT.html The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis. 17/38 Gene Ontology BP GO:0090662 1.94287717068944e-05 3.19772375168772e-05 1280 1723.27272727273 1606 1.76626757177705e-06 427 1.34803454764875 -1.39063209079137 -1 5.62490526575588 1277 2143 2654 1606 2726 427 1113 757 2213 3364 676 1438 M15998 GO_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BINDING.html Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 205/486 Gene Ontology BP GO:0051098 4.97029539071595e-09 4.71210768370877e-08 940 1605 1608 4.5184503654045e-10 231 1.44780091534027 1.80263041476998 1 9.8467160762207 938 1652 1678 1608 231 2448 1587 1071 2320 2791 1331 1439 M15097 GO_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of ions within an organism or cell. 272/819 Gene Ontology BP GO:0050801 1.72183955346954e-08 9.43775506846116e-08 1610 1802.81818181818 1609 1.56530869722327e-09 388 1.7102916854414 1.85656816604935 1 11.153052954318 1609 1000 388 1308 692 3355 2083 3742 2356 420 2878 1440 M11546 GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of B cell proliferation. 18/57 Gene Ontology BP GO:0030890 3.52747599389093e-06 6.69859756222315e-06 1875 1746.72727272727 1612 3.20680149986565e-07 816 1.83963104105219 2.10658617192981 1 8.83542893524948 1875 1612 1522 1225 2362 3129 1927 1330 1253 816 2163 1441 M15321 GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. 36/68 Gene Ontology BP GO:2001244 1.0599324319894e-07 3.4222992223413e-07 1820 1632.45454545455 1612 9.63574984596018e-09 358 1.44293614260456 1.64922893805723 1 8.66025313075431 1820 358 2299 1612 1355 2834 1630 1507 1185 2108 1249 1442 M15365 GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS.html Any apoptotic process that contributes to the shaping of an anatomical structure. 15/28 Gene Ontology BP GO:0060561 4.01390318917216e-06 7.54210947281519e-06 760 1746.45454545455 1613 3.6490095568755e-07 321 1.76764619529842 1.76764619529842 1 8.40518059736611 757 3667 1994 1613 4620 702 385 441 2102 2609 321 1443 M15312 GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 17/34 Gene Ontology BP GO:0090181 1.8747855943698e-06 3.83126299060695e-06 1615 1639.81818181818 1614 1.7043519927433e-07 513 1.65758573215771 -1.35218607031537 -1 8.33444241068217 1614 1552 2053 1851 2193 513 1264 1991 1083 3363 561 1444 M16501 GO_RESPONSE_TO_UV_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_B.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. 7/19 Gene Ontology BP GO:0010224 0.000787829176421227 0.00104810626536497 1325 2001.81818181818 1614 7.88108619526857e-05 727 1.99276708589717 1.99276708589717 1 5.511665571348 727 2448 4572 2651 3418 887 817 1324 2240 1322 1614 1445 M11191 GO_POSITIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_GROWTH.html Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 16/45 Gene Ontology BP GO:0060421 3.10436232981273e-08 1.40073413968129e-07 1800 1483.81818181818 1615 2.82214761237962e-09 589 2.70256617638865 3.0481628460093 1 17.1936085318467 1799 1615 905 589 917 2566 1684 1816 926 1261 2244 1446 M12068 GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. 6/17 Gene Ontology BP GO:0032460 2.7502132469472e-06 5.37425930369354e-06 1590 1868.18181818182 1615 2.75021665060594e-07 734 1.46987632279161 -1.66362421353143 -1 7.19008925724526 1586 734 3846 2312 2324 906 1615 1092 2333 2530 1272 1447 M11914 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. 13/66 Gene Ontology BP GO:0016339 1.30474943813582e-07 4.03057328094786e-07 2190 1771 1616 1.18613592319667e-08 172 1.83497911867178 1.65615774520664 1 10.8922072771651 2190 969 1317 1468 1421 2286 1616 2802 172 1780 3460 1448 M10834 GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that activates or increases the frequency, rate or extent of membrane invagination. 9/22 Gene Ontology BP GO:1905155 0.00100476007824759 0.00131968912116084 795 1896.09090909091 1617 0.00010052146618143 795 2.28629080392736 2.28629080392736 1 6.11113612860994 795 1755 3644 1273 4157 1195 868 1617 2700 1644 1209 1449 M14465 GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. 4/18 Gene Ontology BP GO:0033604 1.22047730602637e-06 2.65045656308721e-06 1160 1650.81818181818 1617 1.22047797633108e-07 14 4.04182409199992 4.04182409199992 1 20.9229162681794 1158 2299 4240 640 2101 2188 1617 397 14 2088 1417 1450 M15200 GO_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. 50/124 Gene Ontology BP GO:0019218 1.68924656410558e-08 9.32227361461289e-08 4370 2232.09090909091 1619 1.53567870643298e-09 128 1.91344938044083 2.07415785959434 1 12.4873698809483 4366 128 900 340 687 2794 4550 4617 454 1619 4098 1451 M12796 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. 54/121 Gene Ontology BP GO:0009063 1.34639741176381e-08 8.20383619792569e-08 3055 1647.63636363636 1621 1.22399765454886e-09 127 1.78161642873772 -1.69088370080292 -1 11.7188083207593 3051 127 818 1578 597 1169 2831 2268 1621 1895 2169 1452 M10228 GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 15/28 Gene Ontology BP GO:0022011 2.43090483110014e-07 6.67456601466466e-07 745 1801.18181818182 1622 2.20991372700422e-08 745 1.28317107565006 1.4126082162203 1 7.35582232276381 745 2855 2464 2755 1622 1062 1218 780 3041 2033 1238 1453 M13919 GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 137/336 Gene Ontology BP GO:0006650 8.32917127935582e-09 6.1818164081492e-08 1545 2365 1622 7.57197391899089e-10 412 1.71351274379846 -1.40368446396971 -1 11.4663317877636 4437 1278 1545 1543 412 2192 4404 4035 1622 1433 3114 1454 M16230 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. 93/197 Gene Ontology BP GO:2001242 1.56795665230517e-08 8.86351497631251e-08 1625 1728 1622 1.4254151486183e-09 665 1.3692589297231 1.5434105772836 1 8.96378193160377 1622 1286 2451 1252 665 3204 1906 1394 2343 2158 727 1455 M11807 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. 18/47 Gene Ontology BP GO:0010881 1.91598450744379e-05 3.15766752886256e-05 685 1645.90909090909 1623 1.7418192672687e-06 344 1.7786939130943 1.93982575682222 1 7.43094432103111 682 2625 2179 2207 3384 522 344 1082 1623 2987 470 1456 M14616 GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT.html The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 15/28 Gene Ontology BP GO:0032292 2.43090483110014e-07 6.67456601466466e-07 750 1798 1623 2.20991372700422e-08 726 1.28317107565006 1.4126082162203 1 7.35582232276381 746 2856 2465 2756 1623 1063 1219 726 3042 2043 1239 1457 M13477 GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of osteoblast proliferation. 23/49 Gene Ontology BP GO:0033688 1.74141243569838e-07 5.05968581911612e-07 985 1938.72727272727 1624 1.58310233958189e-08 882 1.32597613457223 1.35679912917715 1 7.74927432465273 982 3317 2560 2955 1519 989 1071 2179 3248 1624 882 1458 M15426 GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 914/2257 Gene Ontology BP GO:0031399 2.97191096845254e-09 3.68946059532757e-08 1320 1781.54545454545 1625 2.97191097242705e-10 117 1.58756956094393 1.87078548654129 1 10.9538855624207 1317 1644 4403 1661 117 3406 1625 1123 2295 731 1275 1459 M10913 GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. 8/16 Gene Ontology BP GO:0033240 6.5409915695129e-09 5.47858747037603e-08 2825 1591.90909090909 1626 6.54099158876594e-10 19 2.15438117907491 -1.22281022915269 -1 14.5213816780203 2824 232 3658 72 352 1626 2031 2614 19 1516 2567 1460 M12343 GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. 31/66 Gene Ontology BP GO:1900024 8.56108327054264e-08 2.90884951860782e-07 1540 1716.18181818182 1627 7.78280327608069e-09 950 1.47980069926153 1.73375897791322 1 8.97848218723372 1536 1790 1595 1269 1280 2805 1988 950 1627 1636 2402 1461 M13236 GO_RELAXATION_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_MUSCLE.html A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. 19/37 Gene Ontology BP GO:0090075 8.31006804965337e-07 1.88408287630992e-06 1410 1924.54545454545 1628 7.55461017147279e-08 785 2.50024098040805 2.29854784171757 1 13.2867544710825 1410 3151 1451 2272 1978 1628 785 3979 1562 2057 897 1462 M14759 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 9/22 Gene Ontology BP GO:0060100 0.00100476007824759 0.00131968912116084 800 1958.09090909091 1629 0.00010052146618143 796 2.28629080392736 2.28629080392736 1 6.11113612860994 796 1756 4289 1274 4158 1196 869 1629 2701 1661 1210 1463 M15500 GO_POSITIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 548/1446 Gene Ontology BP GO:0051050 2.07648208750783e-08 1.05829926808989e-07 1560 1952.72727272727 1629 2.07648210691083e-09 312 1.75966777723981 2.12513003520393 1 11.3937950695498 1556 1504 4415 1629 807 3702 2209 1493 2103 312 1750 1464 M11100 GO_HYALURONAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 8/19 Gene Ontology BP GO:0030214 1.22610971369123e-07 3.8465050004516e-07 1860 1768.09090909091 1630 1.22610978134176e-08 128 1.68557724517273 2.11866968711794 1 10.0371396184503 1858 1630 3689 1481 1617 2410 2122 128 2192 1517 805 1465 M13100 GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. 57/171 Gene Ontology BP GO:0050709 0.000130181474815842 0.00018876720411304 610 1914.27272727273 1630 1.18353798849308e-05 610 1.56799098199205 1.58808296144018 1 5.42039486610541 610 2815 1630 3516 3065 1167 1047 1287 3109 1096 1715 1466 M11994 GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of an acute inflammatory response. 27/97 Gene Ontology BP GO:0002673 2.30940879693939e-05 3.75703750672375e-05 790 1985.54545454545 1631 2.0994845817109e-06 786 1.80260158419428 1.89795613029663 1 7.40452687853142 786 3316 1552 3458 2761 1508 938 999 2886 1631 2006 1467 M12194 GO_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. 67/235 Gene Ontology BP GO:0009913 1.62052877976866e-08 9.07613404640033e-08 1635 1552.81818181818 1632 1.47320799245958e-09 484 2.07873241717395 2.49575103199855 1 13.5884480018639 1635 2214 750 484 676 3293 2104 1632 955 1432 1906 1468 M13523 GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. 3/19 Gene Ontology BP GO:0006704 5.19465163711885e-05 7.94687563464343e-05 1350 1967.63636363636 1633 5.19477307093931e-06 20 3.76349631243148 3.76349631243148 1 14.3226599706188 1348 3028 4091 1207 3717 1633 921 2171 20 2856 652 1469 M11623 GO_CELL_PROLIFERATION_IN_FOREBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION_IN_FOREBRAIN.html The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. 11/46 Gene Ontology BP GO:0021846 2.94441623245152e-07 7.825371818702e-07 1440 1924.27272727273 1635 2.67674238774884e-08 997 1.86302966679603 -1.86302966679603 -1 10.560413208105 1440 2865 1511 2634 1677 1261 1635 997 3444 2652 1051 1470 M13223 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 20/44 Gene Ontology BP GO:0030947 0.000173331250398871 0.00024815818550785 730 1891.72727272727 1635 1.57586280129823e-05 427 1.72398261109003 1.9682517501561 1 5.76952381983683 728 2950 1635 2997 3868 566 427 1012 3277 2164 1185 1471 M14950 GO_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_LINEAGE_COMMITMENT.html The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. 6/16 Gene Ontology BP GO:0002360 1.81324968980934e-05 3.00783076448187e-05 1535 1840.90909090909 1636 1.81326448541422e-06 406 2.32489533624595 2.32489533624595 1 9.75840324556314 1535 1636 4323 1337 2729 2382 2043 804 406 1736 1319 1472 M13092 GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION.html Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. 21/62 Gene Ontology BP GO:0002026 2.04584606894541e-07 5.75339993828804e-07 1290 1602.45454545455 1639 1.85986023563164e-08 1093 1.89259484327592 1.93871748485307 1 10.9626772033115 1290 1742 1093 1639 1581 1688 1202 1720 1961 1423 2288 1473 M15784 GO_REGULATION_OF_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_CONDUCTION.html Any process that modulates the frequency, rate or extent of cardiac conduction. 31/91 Gene Ontology BP GO:1903779 1.28877662957668e-05 2.19266760392983e-05 605 1806.18181818182 1639 1.17162198126319e-06 605 1.39453384891964 1.21145611050012 1 6.03105700853617 605 1303 1702 2590 2634 633 798 3873 2896 1639 1195 1474 M13483 GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. 204/405 Gene Ontology BP GO:0007264 7.64970295473842e-08 2.65052710027587e-07 2020 1985 1640 6.95427565520829e-09 1004 1.65159190296406 1.80205926055839 1 10.0827217128629 2019 1004 1188 1508 1251 4106 1951 1950 1586 1640 3632 1475 M11265 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. 45/105 Gene Ontology BP GO:1901606 4.6511225696915e-08 1.87458004262827e-07 2265 1496.27272727273 1642 4.22829333456642e-09 135 1.68766463107494 -1.83041879374193 -1 10.5385997066181 2264 135 964 1651 1049 915 2466 1642 2055 1836 1482 1476 M14283 GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. 12/40 Gene Ontology BP GO:0042537 2.63620915467735e-07 7.16203575492507e-07 3865 2050.27272727273 1642 2.39655406415296e-08 413 2.47669158092731 -1.96421724523141 -1 14.1273391908942 3862 567 613 413 1642 3960 4229 3151 679 557 2880 1477 M10725 GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. 10/44 Gene Ontology BP GO:0007202 2.3427866340579e-08 1.15718705765221e-07 1975 1607.90909090909 1643 2.12980605364209e-09 551 2.74863364364318 2.55081919740138 1 17.698335494882 1971 715 782 1837 818 2504 1643 3597 551 861 2408 1478 M11409 GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. 892/2411 Gene Ontology BP GO:0009891 4.35624815709437e-09 4.42011040422397e-08 1490 1869.18181818182 1645 4.35624816563398e-10 218 1.66649879392236 1.95594588569232 1 11.3770912136465 1489 1645 3739 2225 218 3722 1782 1499 2194 512 1536 1479 M11721 GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 33/133 Gene Ontology BP GO:0045913 3.45943006392018e-06 6.58554070798745e-06 1475 1767.09090909091 1645 3.14494136706906e-07 953 2.07090199774957 2.15409442232874 1 9.96039401793849 1475 3290 1645 1741 2356 2002 1324 953 1441 2210 1001 1480 M15271 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 6/17 Gene Ontology BP GO:0044252 6.57704005563364e-05 9.90502659043366e-05 525 1821.90909090909 1645 6.57723472229397e-06 334 1.96499773612721 1.96499773612721 1 7.30366609960963 525 2112 4378 2043 3551 719 334 1645 2298 1082 1354 1481 M12770 GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. 10/22 Gene Ontology BP GO:0061029 1.33510145341959e-07 4.11338822045596e-07 1650 1772.36363636364 1646 1.21372866767467e-08 973 1.5552317291938 1.81199712666929 1 9.21890996538685 1646 973 1279 1885 1427 2217 1500 3069 2412 1333 1755 1482 M13412 GO_CARDIOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. 5/19 Gene Ontology BP GO:0010002 5.50827012548171e-07 1.32196760391753e-06 1650 1807.90909090909 1647 5.50827149082897e-08 139 2.27832874158839 2.51716478952041 1 12.432906626318 1647 736 4071 612 1885 1936 1694 4448 139 1504 1215 1483 M16059 GO_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 391/1000 Gene Ontology BP GO:0030162 7.42206921295819e-09 5.85221359566564e-08 2190 1657.81818181818 1647 6.7473356709071e-10 361 1.66816056358903 2.03608412587049 1 11.199695753103 2188 1647 789 1247 361 3823 2583 659 1862 952 2125 1484 M14398 GO_CELLULAR_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, as carried out by individual cells. 437/1131 Gene Ontology BP GO:0044255 5.38912225593787e-09 4.95479101669694e-08 4495 2217.81818181818 1649 4.89920206285369e-10 255 1.56890149836197 -1.31286461376172 -1 10.6385766105567 4492 261 1035 1620 255 1649 4577 4286 2173 757 3291 1485 M14290 GO_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. 17/63 Gene Ontology BP GO:0006939 3.12293086769051e-06 6.02650374841523e-06 1835 1563.81818181818 1651 2.839032091585e-07 386 3.52115126300155 4.61391224928981 1 17.0615655232076 1831 1158 559 386 2330 2789 2759 1530 395 1814 1651 1486 M13542 GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. 39/94 Gene Ontology BP GO:0050891 2.40478713391512e-09 3.28394901846115e-08 1660 1512.54545454545 1652 2.18617012413068e-10 266 2.17489444299272 2.14037462694182 1 15.1083867968922 1659 349 266 792 1652 2196 1803 3749 1219 411 2542 1487 M12883 GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS.html The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 13/31 Gene Ontology BP GO:0009072 3.48571206805845e-06 6.63013565423818e-06 1535 1803.27272727273 1657 3.16883417353065e-07 737 1.49923618053522 -1.5688302492433 -1 7.20678033982237 1533 1558 2012 2962 2358 737 1180 1657 2468 1783 1588 1488 M12658 GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 17/48 Gene Ontology BP GO:0097237 6.14422449689503e-05 9.29238903553212e-05 1385 1807.81818181818 1658 5.58581463755251e-06 668 1.79262982829945 1.92392161144748 1 6.70913529846349 1385 2361 2041 1253 3130 2310 1658 1197 1634 2249 668 1489 M14720 GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY.html A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. 37/97 Gene Ontology BP GO:0060135 8.19966785783424e-07 1.86622832666296e-06 1255 1959.09090909091 1658 7.45424628541081e-08 727 2.1884739668263 1.71636647454584 1 11.6383660309162 1658 2944 727 1889 1972 1600 1251 4015 2984 1252 1258 1490 M10375 GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-alpha-amino acid across a membrane. 10/33 Gene Ontology BP GO:1902475 6.47564887583218e-07 1.52466722771241e-06 1930 1687.45454545455 1659 5.8869552562956e-08 484 2.09422033906596 2.49251215771382 1 11.3077839170138 1926 2370 1491 2064 1899 2764 1659 996 484 1328 1581 1491 M14312 GO_ARGININE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARGININE_METABOLIC_PROCESS.html The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. 9/21 Gene Ontology BP GO:0006525 3.961339445498e-08 1.66447955162418e-07 2555 1992.27272727273 1660 3.96133951611294e-09 230 2.26778138073522 1.70120341717428 1 14.2698075204711 2553 230 4222 500 1022 2921 1596 3468 300 1660 3443 1492 M12590 GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. 6/18 Gene Ontology BP GO:0002830 6.37301451653758e-07 1.50278854242174e-06 1570 1796.54545454545 1661 6.37301634422745e-08 590 2.67819630972979 -2.6722438988116 -1 14.4765791843065 1567 590 3936 1278 1928 1661 3032 1989 1173 664 1944 1493 M11978 GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 113/267 Gene Ontology BP GO:0008654 4.81481773837407e-08 1.91070074865562e-07 1665 1700.72727272727 1662 4.37710713068084e-09 298 1.41606367281428 -1.36399186923626 -1 8.83169578508404 1662 1436 2512 2542 1070 298 2096 701 2583 3131 677 1494 M13620 GO_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 51/167 Gene Ontology BP GO:0032368 1.64294496001939e-06 3.4361231753919e-06 1245 1675.54545454545 1662 1.49358744269157e-07 954 1.79353107978089 2.07424714725678 1 9.09668733472804 1243 1892 1487 1293 2147 2038 1885 2410 1662 1420 954 1495 M13670 GO_PIGMENT_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. 14/29 Gene Ontology BP GO:0048753 1.60907441774048e-06 3.37440493295801e-06 2160 1779.36363636364 1662 1.46279599510421e-07 212 1.10098606042005 -1.06572808266793 -1 5.59218312136983 2160 212 2763 1552 2138 1118 2709 1662 1226 2443 1590 1496 M11251 GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic hydroxy compound. 212/648 Gene Ontology BP GO:1901615 4.23000084579358e-09 4.33682206598416e-08 3760 1807.36363636364 1664 3.84545532175155e-10 181 1.72813104780075 -1.5705435529547 -1 11.8111037980725 3757 472 479 1193 181 1664 4563 2674 1804 483 2611 1497 M12996 GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS.html The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. 9/15 Gene Ontology BP GO:0019184 1.67131016324786e-05 2.78331889812044e-05 1405 2104.72727272727 1664 1.67132273313038e-06 1023 1.3205245435974 -1.18172839860669 -1 5.58400311411216 1402 2020 3992 3074 2715 1023 1664 1460 2706 1652 1444 1498 M13904 GO_METANEPHRIC_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 17/42 Gene Ontology BP GO:0072210 4.20018843151006e-07 1.05133478970935e-06 1770 1451.90909090909 1665 3.81835384854583e-08 540 1.92055794625739 2.13474427774855 1 10.6578909604262 1767 831 702 1263 1782 2200 1665 2130 540 551 2540 1499 M14001 GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the Notch signaling pathway. 34/96 Gene Ontology BP GO:0008593 3.08753511336677e-07 8.13588282143129e-07 4365 2155.27272727273 1666 2.80685049698115e-08 364 1.96876429978216 -1.35277578699939 -1 11.128875715545 4363 364 806 802 1690 2933 4399 1666 841 1586 4258 1500 M12886 GO_REGULATION_OF_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCRINE_PROCESS.html Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 19/62 Gene Ontology BP GO:0044060 1.39508981116419e-06 2.97264891841915e-06 1670 1801.09090909091 1667 1.26826426894154e-07 402 1.84118537570163 1.66320261123179 1 9.44593230312181 1667 402 1001 2434 2111 1548 1438 4322 2303 902 1684 1501 M10060 GO_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSPORT.html The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/175 Gene Ontology BP GO:0006813 1.26176583011535e-07 3.92127091648298e-07 1545 1816.72727272727 1668 1.14705991134673e-08 717 1.69649727215663 1.81660134015858 1 10.0889992215467 1541 1668 827 2027 1413 2574 1689 3256 2632 717 1640 1502 M12571 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. 11/32 Gene Ontology BP GO:0006359 7.1758295685399e-07 1.66171454796662e-06 1335 1539.81818181818 1669 6.52348355373683e-08 63 3.5171763995851 3.5171763995851 1 18.8690187567026 1332 2244 1798 1488 1937 2040 1669 639 63 2659 1069 1503 M15992 GO_NEUTRAL_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSPORT.html The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/38 Gene Ontology BP GO:0015804 1.83069656308122e-07 5.2794559890597e-07 2615 1935.90909090909 1669 1.66426974129079e-08 1062 2.04521246793731 2.3590462344876 1 11.917581167173 2611 2060 1312 2261 1533 3595 2159 1470 1669 1563 1062 1504 M15438 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. 18/30 Gene Ontology BP GO:0033137 1.14055154985621e-07 3.63457848042716e-07 1100 1701.18181818182 1670 1.03686509907829e-08 1097 1.84455603973764 1.97537336616076 1 11.0259554852799 1097 2887 1528 2273 1378 1939 1789 1196 1670 1107 1849 1505 M16721 GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. 9/30 Gene Ontology BP GO:0090025 1.57532388728846e-05 2.63575812925418e-05 600 1901.36363636364 1670 1.57533505480396e-06 591 2.53386835359802 2.53386835359802 1 10.7704235553489 599 3432 4610 2464 2849 890 591 660 1844 1670 1306 1506 M15745 GO_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON_REORGANIZATION.html A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. 30/107 Gene Ontology BP GO:0031532 1.28070755311237e-06 2.75803579271835e-06 1705 1914.09090909091 1671 1.16428027151256e-07 926 2.17018530091348 2.56983256722387 1 11.1993774714187 1704 3719 1462 1671 2087 2569 1620 926 1033 2710 1554 1507 M16928 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 844/2274 Gene Ontology BP GO:0006357 3.05029357833216e-09 3.71578511927863e-08 1505 2044.81818181818 1671 3.05029358251909e-10 122 1.52236671228829 1.73058105260104 1 10.4996366376003 1504 1197 4638 3133 122 3400 1686 1671 2358 1129 1655 1508 M14332 GO_MECHANORECEPTOR_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANORECEPTOR_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. 25/96 Gene Ontology BP GO:0042490 2.88388036288644e-07 7.68207488518745e-07 925 1622.45454545455 1672 2.62170976447392e-08 864 2.07783284082905 2.41160173136812 1 11.7934865129681 924 2467 1361 1491 1672 2128 1755 1128 1833 2224 864 1509 M13563 GO_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENTATION.html The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. 48/137 Gene Ontology BP GO:0035282 1.9056962262653e-07 5.44096525773715e-07 1675 1724.72727272727 1673 1.73245126485599e-08 1030 2.10516256599057 2.36753940571099 1 12.2413408042623 1673 2546 1272 1810 1552 2277 1482 1496 1778 1030 2056 1510 M10648 GO_EMBRYONIC_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. 16/46 Gene Ontology BP GO:0000578 3.30161336050619e-07 8.60235175804166e-07 1460 1726.63636363636 1674 3.00146714180947e-08 197 2.01336861998702 -2.59716354614939 -1 11.335760078664 2222 1957 1549 1458 1983 1741 4258 197 498 1674 1456 1511 M10784 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. 16/48 Gene Ontology BP GO:0045197 5.67623080762821e-08 2.15140731753615e-07 2670 2221.72727272727 1675 5.16020995825538e-09 458 1.80084422358194 2.13711422747287 1 11.1453523691415 2667 961 1553 1325 1127 4231 2752 4547 458 1675 3143 1512 M10854 GO_LUNG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_CELL_DIFFERENTIATION.html The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. 16/33 Gene Ontology BP GO:0060479 1.777102638835e-08 9.68437506116303e-08 3200 2282.81818181818 1676 1.61554786653634e-09 699 1.72332195076148 1.62852476226997 1 11.220103997601 3197 1554 1422 992 699 4099 2590 2792 1452 1676 4638 1513 M16768 GO_MULTI_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_BEHAVIOR.html Any process in which an organism has a behavioral effect on another organism of the same or different species. 23/106 Gene Ontology BP GO:0051705 2.98003417451613e-07 7.90675968926134e-07 4070 2309.36363636364 1678 2.70912234380001e-08 256 1.72447595897199 -1.43597498744887 -1 9.76784106905612 4067 548 1270 510 1678 3765 4505 2859 256 1627 4318 1514 M12472 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of smooth muscle cell proliferation. 46/99 Gene Ontology BP GO:0048661 8.96694217178795e-08 2.99953260112475e-07 1130 1682.18181818182 1680 8.15176594297274e-09 919 1.76089916574395 1.84481410328163 1 10.6622149199447 1130 2041 1354 1742 1302 2115 1229 1680 3161 919 1831 1515 M10802 GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM.html The growth process in which a branch increases in length from its base to its tip. 10/23 Gene Ontology BP GO:0060602 1.67828382384839e-07 4.94096576560838e-07 1655 1680.18181818182 1681 1.52571268352485e-08 334 1.78504963631434 -1.78504963631434 -1 10.4492797214156 1653 1695 1681 2134 1499 1430 2761 334 1943 1860 1492 1516 M11129 GO_REGULATION_OF_NOREPINEPHRINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOREPINEPHRINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. 6/23 Gene Ontology BP GO:0014061 6.11337254182432e-05 9.24874184154133e-05 1310 2009.09090909091 1681 6.11354072829347e-06 424 2.66078532083072 2.66078532083072 1 9.9633632493188 1306 2643 3697 2589 2966 1651 1681 1289 424 2525 1329 1517 M15167 GO_EMBRYONIC_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_EYE_MORPHOGENESIS.html The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. 21/53 Gene Ontology BP GO:0048048 2.9835543776838e-07 7.90675968926134e-07 3550 2461.36363636364 1681 2.71232252936537e-08 812 1.71505728695733 -1.37131674483677 -1 9.71449147449533 3546 1148 1114 1317 1681 4564 3253 4570 919 812 4151 1518 M14770 GO_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 28/98 Gene Ontology BP GO:0014902 6.6054216528315e-08 2.37928415314947e-07 1685 1477.36363636364 1682 6.00492895559723e-09 428 3.19385399101721 4.23655028891494 1 19.6370052776533 1682 1950 442 474 1189 2865 2058 1848 428 845 2470 1519 M11851 GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). 53/127 Gene Ontology BP GO:0043648 1.79233922228643e-09 2.66700591645339e-08 1685 1593.09090909091 1685 1.62939929431514e-10 35 1.39419478492166 -1.27055667771186 -1 9.80204095889311 1685 931 1981 2302 35 565 1463 2958 2477 1823 1304 1520 M13193 GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. 16/30 Gene Ontology BP GO:0036119 1.18728296057625e-06 2.58562607221178e-06 845 1521.63636363636 1685 1.07934872847506e-07 396 2.01407372156662 2.22841231372172 1 10.4461660482703 843 2728 965 1996 2058 1377 743 396 2199 1685 1748 1521 M14008 GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. 65/154 Gene Ontology BP GO:2000117 4.44625404682332e-08 1.81565149862803e-07 1390 1688.81818181818 1685 4.04204921516656e-09 1033 1.52332433680947 1.81911164640468 1 9.53199371283953 1388 1217 1685 1843 1033 2062 1558 1695 2215 2614 1267 1522 M16656 GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. 16/39 Gene Ontology BP GO:0014065 2.41598263476993e-07 6.6453835149507e-07 2300 1832.27272727273 1690 2.19634809098807e-08 658 1.80819567942879 -1.44557517941854 -1 10.3687381114671 2300 692 1295 658 1620 2732 2258 1814 1595 1690 3501 1523 M12036 GO_ASYMMETRIC_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_CELL_DIVISION.html The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. 11/19 Gene Ontology BP GO:0008356 3.09461483152362e-07 8.14991302482369e-07 2015 1600.36363636364 1691 2.81328660620506e-08 158 1.60078057689205 1.46261840763885 1 9.04765437018509 1054 2736 2265 2775 1691 788 653 1456 2015 2013 158 1524 M16346 GO_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGIONALIZATION.html The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 132/438 Gene Ontology BP GO:0003002 1.86653303636981e-09 2.70421771353233e-08 1725 1557.63636363636 1691 1.69684821632129e-10 43 1.69067590977395 1.82499295688748 1 11.877040362873 856 2609 1318 2131 43 1722 1070 1691 2573 1398 1723 1525 M11267 GO_CELLULAR_COMPONENT_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MAINTENANCE.html The organization process that preserves a cellular component in a stable functional or structural state. 10/26 Gene Ontology BP GO:0043954 1.04552767728324e-07 3.38520572219391e-07 2110 1758.81818181818 1694 9.50479751791712e-09 500 1.44346700505589 1.26471137938631 1 8.66978095740081 2109 1175 2132 2193 1350 1694 673 4392 1267 1862 500 1526 M10216 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 51/133 Gene Ontology BP GO:0034763 6.18067509406135e-08 2.28921327882059e-07 1670 1937.27272727273 1697 5.61879569791009e-09 792 1.38347807589505 1.42338242928052 1 8.52766267102939 1666 792 1928 1332 1158 2545 1418 3823 2426 1697 2525 1527 M11909 GO_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSPORT.html The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 104/370 Gene Ontology BP GO:0015849 3.77203833301558e-08 1.6023397969068e-07 1700 1717.63636363636 1697 3.42912581608141e-09 297 1.93793278506205 2.26597361398149 1 12.2239900855483 1697 1020 328 1256 1331 3887 2679 2261 1879 297 2259 1528 M15117 GO_EPITHELIAL_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MORPHOGENESIS.html The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. 28/69 Gene Ontology BP GO:0003382 3.23959820569136e-08 1.44213369789309e-07 3990 2216.09090909091 1697 2.945089321269e-09 32 2.77760313283629 -2.80743676745954 -1 17.6383749419882 3987 1535 321 32 1697 4129 3758 3504 393 425 4596 1529 M11769 GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. 177/373 Gene Ontology BP GO:0006520 1.49242688604078e-08 8.71614846778283e-08 2185 1454.63636363636 1699 1.3567517237864e-09 617 1.51619659074021 -1.33239862396029 -1 9.93594962116242 2181 617 1120 1745 636 766 2370 1699 1736 1244 1887 1530 M10997 GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that activates or increases the frequency, rate, or extent of cellular extravasation. 6/16 Gene Ontology BP GO:0002693 1.06240545763982e-05 1.83715029416077e-05 1375 1800.09090909091 1701 1.0624105368481e-06 406 2.13409264804678 2.82025467063913 1 9.38168459301701 1372 1931 3669 1208 3099 1259 897 1701 1735 2524 406 1531 M11285 GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. 11/27 Gene Ontology BP GO:0007176 9.86499248449081e-05 0.000145222448019946 1705 2116.90909090909 1702 8.96857715196073e-06 1040 1.03771435641913 -1.2460676268127 -1 3.69698845500309 1702 1480 2520 1664 3025 1310 2755 1040 3092 3314 1384 1532 M15449 GO_KERATINIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINIZATION.html The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. 13/66 Gene Ontology BP GO:0031424 3.16466782618661e-07 8.30613494459268e-07 3475 2218.36363636364 1702 2.87697116492685e-08 468 2.55174391827374 2.92182134320529 1 14.4029924257158 3475 966 545 1010 1702 4636 3451 3160 630 468 4359 1533 M12904 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune system process. 447/1372 Gene Ontology BP GO:0002684 3.73454173758518e-08 1.59223850207603e-07 1705 1810.18181818182 1703 3.39503800089067e-09 421 1.73741917667124 2.05464041663642 1 10.9636303967093 1703 996 421 1495 984 4200 2297 1824 2328 587 3077 1534 M11780 GO_DORSAL_VENTRAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_PATTERN_FORMATION.html The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 38/135 Gene Ontology BP GO:0009953 3.1708113534272e-09 3.82391613349675e-08 1380 1669 1706 2.88255577999748e-10 109 1.53427703027763 1.56986713644448 1 10.5640386801114 1376 1452 1865 1075 109 2526 1417 2536 1706 1922 2375 1535 M14936 GO_POSITIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 231/537 Gene Ontology BP GO:0045862 1.04179255024708e-08 6.96980232103341e-08 3530 2088.90909090909 1706 9.47084141073098e-10 507 1.52539001442997 -1.06955827401274 -1 10.1336913334583 3530 613 1637 1430 507 2164 4206 1350 1972 1706 3863 1536 M16792 GO_LUNG_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_ALVEOLUS_DEVELOPMENT.html The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. 29/56 Gene Ontology BP GO:0048286 4.47401815458381e-07 1.10670571612854e-06 1385 2131.72727272727 1708 4.06729005858215e-08 1210 1.71596076023926 1.54821514676539 1 9.48699845532457 1386 2914 1385 3143 1802 1708 1381 3923 3078 1210 1519 1537 M13604 GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. 7/20 Gene Ontology BP GO:0060766 2.61839437486294e-06 5.14046726532288e-06 715 1762 1709 2.61839746006315e-07 243 0.883908275042955 1.00969495598106 1 4.33959974767555 713 243 4103 1709 2312 571 542 1804 4118 2735 532 1538 M11727 GO_SPECIFICATION_OF_ORGAN_IDENTITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_ORGAN_IDENTITY.html The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. 4/21 Gene Ontology BP GO:0010092 1.84961873774848e-05 3.06108816757909e-05 1715 1806.54545454545 1711 1.84963413283146e-06 237 2.061483559924 2.55631231547495 1 8.63818513969792 1711 882 3796 652 2733 2492 1956 1390 237 1230 2793 1539 M12236 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION.html A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. 10/31 Gene Ontology BP GO:0072378 2.59648196189295e-06 5.10176290692719e-06 1615 1795.09090909091 1712 2.36044093301413e-07 383 2.29648969865751 2.34607228404733 1 11.2817488445587 1612 2891 1151 2147 3083 2088 2021 383 1327 1331 1712 1540 M16940 GO_REGULATION_OF_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of T cell migration. 15/35 Gene Ontology BP GO:2000404 3.14335767794909e-05 5.00157974596217e-05 1170 1976 1713 2.85763871918984e-06 1167 2.3118074635092 3.15159739477258 1 9.22952631200643 1713 2787 1167 1695 2820 2839 2315 1579 1170 1566 2085 1541 M12180 GO_WATER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSPORT.html The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/21 Gene Ontology BP GO:0006833 3.34997777563995e-07 8.7136956931632e-07 2980 2059.27272727273 1714 3.04543480522448e-08 498 2.74935523845555 2.41565987168352 1 15.465291626402 2977 701 498 1232 1714 3208 1975 3766 1113 1598 3870 1542 M16391 GO_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSPORT.html The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 43/164 Gene Ontology BP GO:0006814 3.37566670583545e-07 8.77559939260583e-07 2925 2368 1715 3.06878838526893e-08 1019 1.78598320675047 1.94632068060872 1 10.0411679562365 2922 1595 1019 1195 1715 4559 2738 3869 1496 1402 3538 1543 M12534 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/43 Gene Ontology BP GO:0043267 1.06843080349368e-07 3.43778532267579e-07 1765 1701.54545454545 1716 9.71300777620057e-09 901 1.53483065138403 1.47999978158602 1 9.20899453448282 1762 955 1127 1591 1360 1904 1716 3060 2523 901 1818 1544 M14860 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. 24/61 Gene Ontology BP GO:0030857 3.41125220162774e-07 8.86314715845417e-07 4360 2283.72727272727 1716 3.10113884596919e-08 191 2.40626482182368 -1.9738003916048 -1 13.5188903080024 4359 1542 877 621 1716 2540 4549 4400 191 791 3535 1545 M10978 GO_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 52/130 Gene Ontology BP GO:0009408 0.00029232260978398 0.000407706181203671 1495 2079.36363636364 1717 2.65783144600207e-05 1255 1.9591366500107 2.03415289065801 1 6.16437514556197 1491 3628 1302 2455 3195 2213 1717 1697 2351 1255 1569 1546 M11203 GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 5/13 Gene Ontology BP GO:0009313 9.66649786677858e-05 0.000142526356289149 2020 1954.36363636364 1717 9.66691837783752e-06 614 1.86839800914387 -1.96037590911895 -1 6.67051923271787 2017 1343 3709 1203 3035 1717 2225 1658 614 1498 2479 1547 M16687 GO_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a cell of a different type via adhesion molecules. 15/46 Gene Ontology BP GO:0034113 1.85703808720963e-06 3.79871586296518e-06 1500 1899.36363636364 1718 1.6882178679569e-07 787 2.10513075009714 2.03757399835545 1 10.5919664455612 1499 2240 1644 1242 2190 2207 1718 4052 787 1565 1749 1548 M12878 GO_ORGANIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. 472/1183 Gene Ontology BP GO:0006082 1.94207339875766e-08 1.02002791746966e-07 4440 2051 1720 1.7655212871832e-09 21 1.55530439103753 -1.27184713274211 -1 10.0936428271336 4436 21 569 1720 737 755 4465 4401 2092 554 2811 1549 M14504 GO_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 261/671 Gene Ontology BP GO:0008610 1.68925085046362e-08 9.32227361461289e-08 2780 1723.27272727273 1721 1.53568260312217e-09 592 1.48579788893871 -1.37793558896401 -1 9.69647167569526 2776 611 1834 1721 688 592 3208 1609 2265 2099 1553 1550 M13623 GO_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that modulates the frequency, rate or extent of reproductive process. 67/184 Gene Ontology BP GO:2000241 1.36329251397031e-08 8.2742054148551e-08 2060 1771 1722 1.23935683856213e-09 600 1.7731227625153 1.99257287306696 1 11.6568349217074 2059 1722 852 1104 600 3357 1790 3656 1394 1042 1905 1551 M11276 GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. 9/32 Gene Ontology BP GO:1901385 1.05021172604985e-06 2.31975882209774e-06 1725 1725.09090909091 1723 1.05021222237528e-07 23 2.74506512866952 3.79508085848526 1 14.3575910239439 1723 722 3721 368 2050 2798 2647 1391 23 1647 1886 1552 M12684 GO_PONS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PONS_DEVELOPMENT.html The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. 6/20 Gene Ontology BP GO:0021548 0.00015042804323693 0.000216704128063625 1255 2041.27272727273 1724 1.50438227075455e-05 952 1.62060566238956 1.62060566238956 1 5.51210758535593 1254 2745 3949 2695 3111 1235 952 1100 2435 1724 1254 1553 M16361 GO_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 243/581 Gene Ontology BP GO:0006979 8.08606146274027e-09 6.09517268535486e-08 1335 1553.81818181818 1724 7.35096499314585e-10 400 1.74278184403264 2.05271388402205 1 11.6721091145175 1331 2032 494 1782 400 2890 1724 1397 2418 881 1743 1554 M11501 GO_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of the process of creating protein polymers. 92/225 Gene Ontology BP GO:0032271 4.27823518186296e-08 1.76410710030104e-07 1020 1798.72727272727 1725 3.88930478641798e-09 317 1.5979976004113 1.93603862077583 1 10.0178045934916 2112 317 1654 645 1020 3728 1725 2591 1016 2105 2873 1555 M10669 GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epidermis development. 39/90 Gene Ontology BP GO:0045682 1.29666424154026e-07 4.01093409291901e-07 3165 2189.18181818182 1727 1.1787857436043e-08 707 2.68154566422407 3.28609724567512 1 15.9226011053592 3163 1727 707 858 1419 4425 3366 2633 891 1396 3496 1556 M11737 GO_SINGLE_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves only one organism. 56/124 Gene Ontology BP GO:1902591 1.84599971678062e-08 9.93160681924959e-08 4155 2057 1728 1.67818157479112e-09 512 1.78724240417095 -1.12009692008218 -1 11.6181107084811 4153 512 1314 1425 714 1890 4060 1728 766 2027 4038 1557 M11622 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 43/85 Gene Ontology BP GO:0007173 3.24748421010379e-07 8.48990382179723e-07 3080 2108.45454545455 1729 2.95225880861319e-08 1243 1.55445059891498 -1.89383423575751 -1 8.76018433624562 3076 1527 1729 2006 1707 2238 4348 1243 2353 1704 1262 1558 M12237 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. 37/95 Gene Ontology BP GO:0032024 0.000125631043077578 0.000182453842042288 1175 2018.54545454545 1730 1.14216561649417e-05 957 1.95686051026039 2.28657380211655 1 6.79151540848683 1171 3264 1730 3508 3206 1686 1454 957 2325 1848 1055 1559 M16729 GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 13/23 Gene Ontology BP GO:0048569 1.26322324157578e-06 2.72924407195735e-06 1140 1794.90909090909 1730 1.14838542446321e-07 715 1.41727161837449 1.57436342461359 1 7.3199149341449 1140 1693 2304 2602 2081 1502 715 761 2241 2975 1730 1560 M12850 GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. 10/18 Gene Ontology BP GO:0035024 0.0008292615970145 0.00110065539728099 600 1977.90909090909 1731 7.54158492289826e-05 596 1.80393506747434 1.80393506747434 1 4.95381037556319 596 2334 1897 1731 3620 1443 1382 1310 3508 2478 1458 1561 M14258 GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. 24/50 Gene Ontology BP GO:1901532 3.40350754621083e-05 5.38048537182734e-05 1410 1724.36363636364 1732 3.09414563752437e-06 690 1.67689058371936 -1.48842967292277 -1 6.64535479952258 1406 1460 1405 1845 2840 690 2005 1732 2588 1751 1246 1562 M14059 GO_NEGATIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BINDING.html Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 84/229 Gene Ontology BP GO:0051100 2.28520269288049e-06 4.5517786799846e-06 1310 1887.72727272727 1733 2.07745915144463e-07 693 1.439646339879 1.86229824951501 1 7.13861737344777 1307 1661 1733 1211 2254 3341 1938 693 2377 2878 1372 1563 M10656 GO_SECRETION_BY_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION_BY_CELL.html The controlled release of a substance by a cell. 261/746 Gene Ontology BP GO:0032940 1.09636246081779e-08 7.18984591183189e-08 1735 1695.18181818182 1734 9.96693151164972e-10 317 1.79554181319243 2.1901618628041 1 11.9059034692673 1734 1199 317 1260 523 3553 2131 2249 1995 387 3299 1564 M16308 GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 25/46 Gene Ontology BP GO:0060444 4.02679514025567e-08 1.68284516977561e-07 2980 2092 1735 3.66072292178235e-09 372 2.05892851017276 2.07979081800383 1 12.946511572169 2978 1735 664 586 1006 3932 2708 4031 372 696 4304 1565 M11200 GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. 13/26 Gene Ontology BP GO:2000251 1.10530425141229e-06 2.42644332827766e-06 1165 1828.72727272727 1736 1.00482255157247e-07 830 2.20348082602066 2.76747411775802 1 11.4849862470074 1164 2663 1736 2579 2045 1551 1231 830 2268 2954 1095 1566 M12165 GO_HYPOTHALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPOTHALAMUS_DEVELOPMENT.html The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. 8/35 Gene Ontology BP GO:0021854 9.29432975571497e-09 6.60851042201908e-08 2550 1893.45454545455 1736 9.29432979458802e-10 434 1.72091049957489 2.17021615499072 1 11.4695293707839 2550 434 3863 778 493 3689 3058 1736 917 966 2344 1567 M15071 GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. 6/23 Gene Ontology BP GO:0046321 7.68266796266223e-05 0.000114733442748925 1455 2210.54545454545 1737 7.68293358082808e-06 1274 1.45022551729408 1.45022551729408 1 5.30438521724398 1453 1706 4343 2448 3003 1734 1274 1523 3071 1737 2024 1568 M12561 GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 9/50 Gene Ontology BP GO:0071378 1.34974378333025e-05 2.28717532335853e-05 1585 1937.45454545455 1738 1.3497519815376e-06 1120 1.56025439868876 -1.79025384526688 -1 6.72121967022466 1584 1486 3931 1777 2674 1120 1750 1553 1738 2344 1355 1569 M11354 GO_HYPEROSMOTIC_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPEROSMOTIC_RESPONSE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. 16/43 Gene Ontology BP GO:0006972 1.19885439515805e-07 3.79391724691918e-07 2245 1855.45454545455 1739 1.08986769135244e-08 1248 1.59960506978484 -0.991520868340137 -1 9.53407650665796 2244 1403 2076 1248 1389 2321 1476 1361 2462 2691 1739 1570 M15232 GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. 590/1532 Gene Ontology BP GO:0051248 2.33384397659252e-09 3.21544141938251e-08 1740 1960 1739 2.33384397904359e-10 69 1.7017685403466 2.04318480948824 1 11.8361759547138 1739 2252 4373 1558 69 4227 1913 982 1847 1621 979 1571 M15995 GO_MESENCHYME_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_MORPHOGENESIS.html The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. 23/58 Gene Ontology BP GO:0072132 2.29544318233049e-08 1.13986552893695e-07 1985 1523.72727272727 1739 2.08676655116433e-09 564 2.38485062668087 2.61197862991143 1 15.3704520500861 1984 1739 564 678 808 3013 1791 2475 618 741 2350 1572 M10278 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 27/52 Gene Ontology BP GO:0042771 1.55221305067685e-06 3.27438673070995e-06 1740 1947.72727272727 1740 1.41110376894909e-07 1035 1.36815539347181 -0.908060515745667 -1 6.96579833555008 2314 1306 2275 1740 2128 2543 1740 1035 1365 3302 1677 1573 M10296 GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that modulates the frequency, rate or extent of protein activation cascade. 12/46 Gene Ontology BP GO:2000257 2.99998687065562e-06 5.81584093547142e-06 815 1823 1740 2.72726451048792e-07 812 1.74735254371213 1.8663939963035 1 8.49177539054941 812 2759 1740 3384 2322 1117 818 838 2562 2177 1524 1574 M11034 GO_C21_STEROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 11/43 Gene Ontology BP GO:0008207 2.72002617465031e-09 3.55203396742438e-08 3500 2339.18181818182 1741 2.47275107092117e-10 77 1.62639636736303 -1.18764298807851 -1 11.2466709494904 3499 575 1741 1165 77 4509 3485 4424 1071 1442 3743 1575 M11255 GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 51/124 Gene Ontology BP GO:0051341 6.09330723153998e-08 2.26874302133441e-07 2440 1868.36363636364 1741 5.53937036391401e-09 515 1.78918465979698 -1.39015556381752 -1 11.034888708154 2437 515 769 1189 1153 3738 2023 3310 1741 795 2882 1576 M12246 GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an external stimulus. 522/1381 Gene Ontology BP GO:0032101 1.32453830299579e-08 8.13469754075326e-08 1390 1772.90909090909 1741 1.3245383108906e-09 327 1.6672016235239 1.94704387007607 1 10.9719186898827 1389 748 3875 1355 629 3210 1816 1741 2201 327 2211 1577 M12956 GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of muscle cell differentiation. 91/264 Gene Ontology BP GO:0051147 4.12810009324491e-08 1.71591483732642e-07 1665 1639.45454545455 1741 3.75281833700452e-09 536 1.81660507562149 2.01746174087309 1 11.4085337174091 1663 1024 679 1877 1012 3221 1741 2598 1899 536 1784 1578 M16579 GO_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that modulates the frequency, rate or extent of lymphocyte migration. 21/59 Gene Ontology BP GO:2000401 5.83200668484609e-07 1.39004142904211e-06 1170 1654.90909090909 1741 5.30182566441853e-08 673 2.34630200806129 3.06696785206443 1 12.756343766873 1741 2318 673 1166 1874 3069 2092 1017 1166 814 2274 1579 M12147 GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. 12/22 Gene Ontology BP GO:0045540 3.63459769002823e-05 5.71330328574756e-05 2375 1782.27272727273 1742 3.30423430748814e-06 621 1.99341031666114 -1.70829393659287 -1 7.85145962604362 2374 1253 1742 1560 2850 935 1795 2927 751 2797 621 1580 M16736 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS.html Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. 19/76 Gene Ontology BP GO:0021955 2.2431180359996e-05 3.65945082260932e-05 1395 1859.90909090909 1744 2.03921900648867e-06 878 1.7275010545288 1.75927233055773 1 7.11436541191008 1392 3242 2126 1744 2753 1371 878 1817 1147 2560 1429 1581 M16068 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. 14/30 Gene Ontology BP GO:1901380 1.07381336764384e-07 3.4527115415307e-07 1875 1673.45454545455 1745 9.76194018233044e-09 565 1.50312257816433 1.44909477558022 1 9.01612057835395 1873 565 1277 1686 1361 2308 1745 2454 2070 1026 2043 1582 M11145 GO_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_MORPHOGENESIS.html The process in which the anatomical structures of the lung are generated and organized. 24/70 Gene Ontology BP GO:0060425 3.71880444717478e-08 1.58903171771582e-07 2345 1937 1746 3.38073137276017e-09 981 1.91499489238522 -1.58182216726096 -1 12.0857422572606 2341 1461 1263 1328 981 3501 1772 2850 1204 1746 2860 1583 M13818 GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. 12/21 Gene Ontology BP GO:0031293 9.22351557916373e-05 0.000136254479268397 915 1652 1746 8.38536572582386e-06 157 1.19272749819703 -0.845693263435969 -1 4.27989185147969 1746 217 2283 911 3021 912 1455 2350 157 2807 2313 1584 M14020 GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 86/231 Gene Ontology BP GO:0072330 3.67945154647202e-07 9.43329294879602e-07 2895 2203.63636363636 1746 3.34495651077485e-08 939 1.79505668338615 2.18034563322843 1 10.0398822546916 2894 1125 939 1685 1738 3990 3098 2794 1746 1037 3194 1585 M16060 GO_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTOSIS.html A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. 267/858 Gene Ontology BP GO:0006897 1.37783107219099e-08 8.32189868277674e-08 1210 1567 1746 1.25257370983652e-09 364 1.81361841402281 2.06766281187028 1 11.9188585358486 1210 610 364 1746 604 3232 1862 2430 1786 619 2774 1586 M10283 GO_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. 168/410 Gene Ontology BP GO:0006644 6.02915359592288e-09 5.16534136141885e-08 4075 2259.27272727273 1747 5.48104873858719e-10 294 1.64165352383303 -1.37971508921908 -1 11.1043592849302 4071 1206 1525 1747 294 1861 4572 3716 1719 1371 2770 1587 M12765 GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive nitrogen species. 9/26 Gene Ontology BP GO:2001057 4.43510888564574e-07 1.10118773027022e-06 2090 1854.45454545455 1747 4.43510977080458e-08 758 2.09818467674209 -2.39122130581281 -1 11.6044202958851 2087 1627 3957 1336 1831 1200 2106 2100 1747 1650 758 1588 M13541 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 59/147 Gene Ontology BP GO:0010522 2.32836429697655e-08 1.15128811830268e-07 1915 1616.90909090909 1748 2.11669483783522e-09 121 1.72890434416643 -1.52820372302164 -1 11.1359037777739 1915 121 1275 1039 815 3194 1748 2666 1936 1015 2062 1589 M12264 GO_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CONTRACTION.html A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. 76/194 Gene Ontology BP GO:0006941 4.99514204441131e-09 4.71210768370877e-08 1855 1725.90909090909 1749 4.54103823250261e-10 289 2.42838470438662 2.86180884685385 1 16.515816956941 1854 1888 289 1089 1258 2937 1749 3821 1031 377 2692 1590 M16390 GO_EPITHELIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. 7/23 Gene Ontology BP GO:0072148 3.45119229543939e-07 8.95689537603416e-07 1875 1694.81818181818 1750 3.45119283142229e-08 71 2.59972312034941 3.33843045665778 1 14.5947515143382 1871 589 4557 71 1750 3037 2409 698 350 1984 1327 1591 M16601 GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 132/322 Gene Ontology BP GO:0034599 3.3188579286171e-09 3.8784525079493e-08 1300 1809.63636363636 1750 3.01714357602166e-10 121 1.69828643257798 1.97069301151224 1 11.683605950235 1296 3337 969 2022 121 2536 1646 1750 2776 2111 1342 1592 M13214 GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS.html The process in which the right cardiac ventricle is generated and organized. 11/27 Gene Ontology BP GO:0003215 1.41068353504647e-08 8.40796361132319e-08 1785 1718.36363636364 1752 1.28243958553823e-09 615 2.01958541094746 2.39240626274177 1 13.2640693154255 2302 1752 1269 1102 615 3535 1785 1974 1337 1448 1783 1593 M15341 GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of cell projection assembly. 109/259 Gene Ontology BP GO:0060491 1.68848840100818e-08 9.32227361461289e-08 1755 1889.27272727273 1752 1.53498946724295e-09 686 1.61339695042731 1.85346120314231 1 10.5291964499026 1752 2456 1607 1523 686 3115 1538 1682 1812 1890 2721 1594 M10907 GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 29/68 Gene Ontology BP GO:0048146 2.18868291528331e-07 6.0960136626637e-07 2655 2281.09090909091 1753 1.98971193911431e-08 861 1.85953926769339 -1.62475900428907 -1 10.7278430493471 2652 1456 861 1327 1596 3976 2494 4179 1753 931 3867 1595 M14397 GO_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 142/323 Gene Ontology BP GO:0006732 8.38550510756692e-08 2.85439151132208e-07 595 1857.09090909091 1754 7.62318675198934e-09 108 1.20131757335958 -1.03506998919435 -1 7.29797772919037 595 2034 2960 3690 1278 108 727 1754 2923 3719 640 1596 M12213 GO_RESPONSE_TO_GLUCAGON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GLUCAGON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 27/61 Gene Ontology BP GO:0033762 3.79440229662869e-07 9.65866768818366e-07 2235 1888.81818181818 1755 3.4494572282365e-08 380 2.0467831100874 1.67076070322922 1 11.4283246014021 2232 380 763 1755 1749 2969 2162 2791 1488 1033 3455 1597 M11021 GO_ADULT_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_WALKING_BEHAVIOR.html The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 21/79 Gene Ontology BP GO:0007628 3.86834480273346e-07 9.80924353855349e-07 1765 1750.09090909091 1757 3.51667771174509e-08 1001 1.65483872167519 2.06381762344814 1 9.22956169727025 1764 2266 1631 1386 1757 2203 1368 2260 1001 1065 2550 1598 M11314 GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS.html Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 6/12 Gene Ontology BP GO:0050930 3.99208883805756e-06 7.51632947084398e-06 625 1571.81818181818 1757 3.99209600962367e-07 237 2.6074731032078 2.6074731032078 1 12.4021677457665 623 2495 3728 1916 2408 310 237 720 1757 2526 570 1599 M16566 GO_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_WALKING_BEHAVIOR.html The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 21/79 Gene Ontology BP GO:0090659 3.86834480273346e-07 9.80924353855349e-07 1765 1746.81818181818 1758 3.51667771174509e-08 1002 1.65483872167519 2.06381762344814 1 9.22956169727025 1765 2267 1632 1387 1758 2204 1369 2211 1002 1069 2551 1600 M14209 GO_NEGATIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_T_CELL_SELECTION.html The process of elimination of immature T cells which react strongly with self-antigens. 7/20 Gene Ontology BP GO:0043383 6.54831607663996e-06 1.17707439194113e-05 1010 1903.09090909091 1760 6.54833537291953e-07 216 1.79478172649178 1.79478172649178 1 8.21214985541998 1006 3194 4204 2792 2828 758 216 523 1760 2741 912 1601 M15578 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. 9/31 Gene Ontology BP GO:2000353 6.81482214684572e-08 2.43497648363109e-07 1760 1898.09090909091 1760 6.81482235583382e-09 716 2.30508863446575 2.69446025466091 1 14.1510435208858 1760 716 4427 747 1242 2867 2386 2030 928 751 3025 1602 M16363 GO_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of JUN kinase activity. 56/166 Gene Ontology BP GO:0043506 7.65530226463482e-08 2.65052710027587e-07 1275 1856.36363636364 1762 6.95936593728641e-09 1184 1.71491225105697 2.05717841065366 1 10.469282981628 1271 2816 1720 2760 1252 1762 1272 1184 2389 2028 1966 1603 M13756 GO_VESICLE_COATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COATING.html A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. 56/116 Gene Ontology BP GO:0006901 7.73596641811858e-09 5.94670398664314e-08 3915 1913.90909090909 1765 7.03269676847359e-10 380 1.81663475851967 -1.17153354019244 -1 12.1847915531177 3914 509 1300 926 380 2010 4081 1791 557 1765 3820 1604 M16961 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. 17/23 Gene Ontology BP GO:0032703 0.000187163344894159 0.000267137845171712 1450 2013.36363636364 1765 1.70162972337857e-05 999 2.10306277999326 1.82799706374707 1 6.97567986804238 1449 1747 1297 1765 3128 2318 1947 3420 1257 999 2820 1605 M10207 GO_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION.html The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. 22/80 Gene Ontology BP GO:0051899 4.0002833167506e-07 1.01037922832391e-06 2665 2008.90909090909 1766 3.63662185829685e-08 527 1.90468064098403 2.30373222405892 1 10.6002922331032 2662 824 1153 527 1766 3944 3086 2921 754 1545 2916 1606 M10136 GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 131/337 Gene Ontology BP GO:0046394 8.82202762867208e-08 2.96386934008137e-07 2800 2090.27272727273 1769 8.02002543857866e-09 68 1.68871987920622 1.99325208261419 1 10.2333133315701 2797 68 933 1540 1294 3817 3023 3164 1769 1059 3529 1607 M15792 GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that activates or increases the activity of a monooxygenase. 19/35 Gene Ontology BP GO:0032770 8.44586316407696e-07 1.91195234864989e-06 2860 2034.18181818182 1769 7.67806036951802e-08 850 2.10991866656281 -1.44653899080727 -1 11.2000178810685 2858 1313 1070 1190 1984 4102 2783 1769 850 1223 3234 1608 M10685 GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. 50/156 Gene Ontology BP GO:0045833 3.05049691739596e-09 3.71578511927863e-08 2435 1703.45454545455 1770 2.77317901965976e-10 104 1.80929331065911 1.95114850175209 1 12.4785455685017 2433 1039 1090 860 104 3752 1982 1770 1177 2205 2326 1609 M11621 GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). 28/58 Gene Ontology BP GO:0007223 7.2907207924397e-06 1.30145392692416e-05 970 1818.18181818182 1770 6.62794995794365e-07 970 1.71357350991413 1.93353191776031 1 7.77118446013198 970 2685 2153 2098 2515 1514 970 1371 2784 1770 1170 1610 M11689 GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. 131/337 Gene Ontology BP GO:0016053 8.82202762867208e-08 2.96386934008137e-07 2800 2096.45454545455 1770 8.02002543857866e-09 69 1.68871987920622 1.99325208261419 1 10.2333133315701 2798 69 934 1541 1295 3818 3024 3222 1770 1060 3530 1611 M14798 GO_SOMATIC_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_DIVISION.html The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. 12/39 Gene Ontology BP GO:0048103 9.6507769879513e-08 3.18922117829593e-07 2020 1847.54545454545 1770 8.773434010276e-09 859 1.80685740294242 1.65264326162601 1 10.8958248389017 2018 859 1183 922 1321 3120 2649 3382 1919 1180 1770 1612 M11757 GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of phospholipid metabolic process. 48/120 Gene Ontology BP GO:1903725 1.25706274866785e-07 3.9167749389902e-07 725 1884 1772 1.14278438226858e-08 721 1.71652955598739 1.91269814628319 1 10.2089242618181 721 3084 1377 2895 1409 1825 1347 1157 3179 1772 1958 1613 M13800 GO_MAINTENANCE_OF_CELL_NUMBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_NUMBER.html Any process by which the numbers of cells of a particular type in a tissue are maintained. 94/209 Gene Ontology BP GO:0098727 5.89016277993828e-09 5.10759174186147e-08 3565 2172.45454545455 1772 5.3546934506439e-10 288 1.81122398753533 -1.52441888848908 -1 12.2595655797796 3564 1772 853 734 288 2625 2879 4365 1615 1041 4161 1614 M15717 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. 58/166 Gene Ontology BP GO:0045638 8.34480249489897e-08 2.84262054173264e-07 1390 1894.45454545455 1776 7.58618437402276e-09 833 1.873125716765 -1.82112126276093 -1 11.3823179205449 2187 1776 1389 3088 1276 833 2828 1878 2635 1389 1560 1615 M10343 GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. 32/89 Gene Ontology BP GO:1904035 2.32756993149036e-08 1.15128811830268e-07 1780 1596 1777 2.11597268737794e-09 360 1.83658995266986 2.13991931719575 1 11.829508719277 1777 360 621 679 814 2919 2017 2467 1955 576 3371 1616 M11037 GO_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMISSION_OF_NERVE_IMPULSE.html The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. 14/102 Gene Ontology BP GO:0019226 1.62729283250425e-05 2.71293379580511e-05 1240 1687.36363636364 1777 1.47936806305918e-06 334 2.3512940648822 2.49232605530819 1 9.96701990722006 1239 3275 1453 1876 2911 1801 1834 650 334 1411 1777 1617 M16466 GO_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION.html Long distance growth of a single axon process involved in cellular development. 19/63 Gene Ontology BP GO:0048675 0.000219928825953364 0.000311035497685492 590 1860.90909090909 1777 1.99955286180328e-05 589 1.749767088226 1.93235936242974 1 5.69650745081464 589 3271 1777 2522 3446 1113 959 1058 1963 2063 1709 1618 M10812 GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 108/272 Gene Ontology BP GO:0071216 7.61563864486599e-08 2.64468288916326e-07 1600 1948.81818181818 1780 6.92330809863004e-09 894 1.81069139706392 2.05400024547355 1 11.0556116433132 1599 2457 894 1645 1249 3339 1780 1653 2093 2218 2510 1619 M14949 GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS.html The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. 19/37 Gene Ontology BP GO:0046716 3.73364966742618e-08 1.59223850207603e-07 2205 1833.81818181818 1780 3.39422702799133e-09 760 1.61177631173947 1.71731468726251 1 10.1707866332656 2205 1469 1667 1001 983 3318 2818 1780 760 2060 2111 1620 M11122 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 11/27 Gene Ontology BP GO:0010875 8.61548923315956e-05 0.000127719401371519 1595 2080.81818181818 1783 7.83256967776705e-06 895 1.70265496626538 2.10135721094429 1 6.15407910782672 1593 3349 2210 2298 3358 1783 1391 895 1317 3313 1382 1621 M13309 GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 production. 28/103 Gene Ontology BP GO:0032652 1.98846755850894e-06 4.02636496910467e-06 1425 1941.09090909091 1785 1.80769941435037e-07 1096 1.94693546236267 1.7779600613258 1 9.75032585512422 1425 3052 1785 2662 2211 1926 1096 1168 2938 1771 1318 1622 M13488 GO_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BROWN_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 17/40 Gene Ontology BP GO:0050873 6.19822880458561e-09 5.27076489737931e-08 1285 1655.72727272727 1785 5.63475347458942e-10 205 1.71985592365519 1.94933964256552 1 11.6193221345658 1282 205 1133 2626 303 1785 1275 3157 1946 2253 2248 1623 M16446 GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT.html The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. 24/58 Gene Ontology BP GO:0031076 4.24787343261012e-07 1.060940094008e-06 4125 2528.54545454545 1785 3.8617038661924e-08 792 1.66765435774625 -1.33026637489738 -1 9.24832038843266 4125 1057 1331 1412 1785 3996 3375 4022 1424 792 4495 1624 M10050 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. 22/50 Gene Ontology BP GO:0048008 4.25962519730542e-07 1.06330321457468e-06 770 1522.72727272727 1786 3.872387292774e-08 219 1.48306189435155 1.49994664865397 1 8.2232946539245 766 2138 1792 2171 1786 455 219 815 3039 2867 702 1625 M16328 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. 25/69 Gene Ontology BP GO:0051155 1.31711282577748e-06 2.82594956103736e-06 2080 1755.18181818182 1786 1.19737601301575e-07 172 2.19533813362681 2.39074788997253 1 11.3076514448664 2080 172 953 697 2096 3563 1786 3245 1371 1157 2187 1626 M14739 GO_HINDBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_MORPHOGENESIS.html The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. 33/80 Gene Ontology BP GO:0021575 1.0862838306473e-08 7.13382719334568e-08 3950 2190.27272727273 1787 9.87530760009992e-10 397 1.94598943885923 -1.49809055160818 -1 12.9096299581666 3950 2045 1192 397 522 3717 3930 1787 1010 953 4590 1627 M12092 GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving guanosine-containing compounds (guanosines). 24/59 Gene Ontology BP GO:1901068 7.66128506073066e-08 2.65062194761345e-07 1355 2251.18181818182 1788 6.96480484320675e-09 922 0.988292393003118 -0.97432334694663 -1 6.03336300568683 1788 2820 2984 3867 1253 922 1352 1130 3804 3492 1351 1628 M16578 GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. 13/33 Gene Ontology BP GO:0045940 2.75256832005506e-05 4.42067613629043e-05 3480 1874.72727272727 1790 2.50236614536028e-06 219 2.67650607111841 -3.20267572264428 -1 10.8187426174966 3478 219 993 1171 2790 2450 4162 1302 383 1790 1884 1629 M14053 GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. 24/77 Gene Ontology BP GO:0050710 8.05805348668397e-05 0.000120069134591379 1495 2165.45454545455 1791 7.32577149845575e-06 889 1.59621240317445 1.73554542649986 1 5.80910020004486 1494 3475 1791 3044 3258 1960 1098 889 3283 1749 1779 1630 M10848 GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. 30/98 Gene Ontology BP GO:2000737 3.7521629211839e-07 9.58266911059233e-07 3125 2199.36363636364 1792 3.41105778284197e-08 884 1.69750418495065 2.00922186515962 1 9.48351261284684 3123 1792 1686 884 1744 4088 2923 1269 1184 2706 2794 1631 M12885 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. 33/92 Gene Ontology BP GO:1903727 6.52628196415831e-08 2.35260304034061e-07 1225 1829.81818181818 1792 5.93298377978175e-09 1187 1.92830034347002 2.17081193917618 1 11.8646760876428 1222 2720 1213 2220 1187 1988 1792 1417 3047 1241 2081 1632 M14433 GO_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANOIKIS.html Any process that modulates the frequency, rate or extent of anoikis. 32/78 Gene Ontology BP GO:2000209 2.40809932147535e-08 1.17692685785369e-07 1625 1830.72727272727 1794 2.18918122530379e-09 829 1.46760444643176 1.61131565242343 1 9.43983525981618 1621 1225 1641 2576 829 2293 1165 2689 2341 1794 1964 1633 M11377 GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. 44/102 Gene Ontology BP GO:0008652 5.09391868084346e-08 1.99250753455402e-07 2330 2073.27272727273 1795 4.63083527162632e-09 527 1.7754217995717 -1.4336620146551 -1 11.0429314716027 2330 527 1225 1194 1088 4165 2833 3684 625 1795 3340 1634 M11425 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE.html Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. 8/29 Gene Ontology BP GO:0042749 0.0006567915301507 0.000880844331163981 1725 2183.45454545455 1795 6.56985729737709e-05 1518 1.74966441868673 1.93519719510116 1 4.961916293686 1721 1700 3744 2173 3312 2475 1541 1561 1795 1518 2478 1635 M15705 GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. 14/55 Gene Ontology BP GO:0042462 4.41233712504205e-07 1.09611991822206e-06 1945 1673.09090909091 1795 4.01121637271279e-08 725 2.03712206185729 2.59577417677291 1 11.2704897505696 1942 1084 1009 1513 1795 2831 2367 2363 938 725 1837 1636 M16698 GO_ASTROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DEVELOPMENT.html The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 11/39 Gene Ontology BP GO:0014002 4.04217675006614e-06 7.58602532358815e-06 1795 1693.81818181818 1795 3.67471288817372e-07 119 2.43915753978484 2.92107168702891 1 11.5925168268835 1795 2284 1611 925 3186 2766 2377 445 119 2026 1098 1637 M15004 GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. 38/80 Gene Ontology BP GO:0043666 2.30390501684099e-06 4.58313238782894e-06 1800 1941.81818181818 1797 2.09446129960178e-07 1344 1.55293132139614 2.08312501607446 1 7.69605371805344 1784 1670 1797 1344 2258 3143 1653 2641 1797 1924 1349 1638 M11301 GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0033865 1.34881049277819e-07 4.13641157065334e-07 3275 2084.45454545455 1799 1.22619143224836e-08 229 1.89072683666226 -1.5305637273799 -1 11.2033619411322 3275 1088 1799 1402 1433 1307 2718 4548 229 2299 2831 1639 M11973 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. 72/218 Gene Ontology BP GO:0070665 4.46375056039694e-07 1.10534367210256e-06 2665 2080.81818181818 1800 4.05795587825651e-08 768 1.64625746068753 2.14919902181318 1 9.10244848041648 2663 1127 974 1420 1800 4410 2646 884 2181 768 4016 1640 M12620 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0034032 1.34881049277819e-07 4.13641157065334e-07 3280 2086.09090909091 1800 1.22619143224836e-08 230 1.89072683666226 -1.5305637273799 -1 11.2033619411322 3276 1089 1800 1403 1434 1308 2719 4555 230 2301 2832 1641 M12642 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. 69/180 Gene Ontology BP GO:1903169 1.04013969779291e-08 6.96878588290404e-08 2105 1652.63636363636 1800 9.45581547918729e-10 402 1.78369378510699 -1.36649755125778 -1 11.8497971708196 2049 920 1363 402 506 3346 2101 1850 1739 1800 2103 1642 M16681 GO_SYNCYTIUM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNCYTIUM_FORMATION.html The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. 16/57 Gene Ontology BP GO:0006949 1.70293746574832e-07 4.97592111609153e-07 2335 1814.72727272727 1800 1.54812508869667e-08 574 2.33158648542274 -1.31740979979914 -1 13.6419574077705 2333 2096 1024 990 1510 3344 2521 1800 574 1691 2079 1643 M13130 GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0033875 1.34881049277819e-07 4.13641157065334e-07 3280 2087 1801 1.22619143224836e-08 231 1.89072683666226 -1.5305637273799 -1 11.2033619411322 3277 1090 1801 1404 1435 1309 2720 4553 231 2304 2833 1644 M10364 GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. 32/86 Gene Ontology BP GO:0048641 5.16399265502215e-09 4.82163228585794e-08 1805 1546.81818181818 1803 4.6945387883122e-10 243 1.80054076072802 2.20209412200599 1 12.2290755333447 1803 1996 1477 2132 243 2717 1985 645 1884 1793 340 1645 M12370 GO_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_SIGNAL_TRANSDUCTION.html The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. 826/2025 Gene Ontology BP GO:0035556 9.02477237601311e-09 6.49643692121378e-08 1540 1874.45454545455 1803 9.02477241266404e-10 474 1.58726907694576 1.79345003913588 1 10.5897805188438 1537 887 3897 1507 474 3748 1811 1803 1929 848 2178 1646 M12750 GO_ATP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 20/46 Gene Ontology BP GO:0006754 2.1884974408473e-05 3.57410960881253e-05 815 1922.54545454545 1804 1.98956291972793e-06 644 0.908071685384853 -0.87257992153392 -1 3.74834872161244 811 1804 3110 2174 2750 644 841 1246 2887 3602 1279 1647 M14400 GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein homooligomerization. 10/19 Gene Ontology BP GO:0032462 1.16380247155481e-07 3.70358798864222e-07 2485 1893 1804 1.05800230283645e-08 718 1.5206283645535 -1.43018587134864 -1 9.07812608604254 2485 718 1319 1804 1380 1347 2853 2846 2438 1876 1757 1648 M10463 GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. 9/22 Gene Ontology BP GO:0033599 4.07755455326835e-07 1.02612931115582e-06 870 1758.27272727273 1806 4.07755530145884e-08 154 1.43070039454436 -1.43070039454436 -1 7.95348535999223 866 3189 3590 2327 1806 248 196 220 3683 3062 154 1649 M11678 GO_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a leukocyte. 84/448 Gene Ontology BP GO:0002443 1.80067463778523e-09 2.66700591645339e-08 1810 1837.63636363636 1806 1.63697694478096e-10 36 1.68862547336467 2.3482683757745 1 11.8720685898339 1806 2813 1590 2555 36 3052 1433 1203 2152 2117 1457 1650 M15393 GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-glutamate across a membrane. 5/13 Gene Ontology BP GO:0089711 4.30656715248341e-06 8.03673283319151e-06 1525 1886.27272727273 1806 4.30657549844047e-07 69 3.45070921143932 3.45070921143932 1 16.3198028916731 1525 3195 4395 1867 2425 1806 1191 968 69 2287 1021 1651 M10316 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 27/84 Gene Ontology BP GO:0010518 5.89633679439532e-09 5.10759174186147e-08 3070 2103.81818181818 1808 5.36030619108946e-10 289 2.35552856885616 2.07095678909732 1 15.9437801589655 3067 1228 728 1808 289 3938 2745 3189 897 781 4472 1652 M11019 GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein oligomerization. 17/43 Gene Ontology BP GO:0032459 4.73345900133364e-08 1.89297589519312e-07 3810 2017.45454545455 1808 4.30314463925221e-09 843 2.00803306509842 -1.43018587134864 -1 12.5312309467357 3807 843 1189 1527 1059 2020 3837 2257 1342 1808 2503 1653 M14268 GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY.html Any process that modulates the activity of the enzyme phospholipase A2. 12/30 Gene Ontology BP GO:0032429 1.04671884104288e-05 1.811373678331e-05 2435 2007.27272727273 1808 9.51567110153152e-07 1194 2.72783373303633 1.95049189459948 1 12.0073685988959 2431 2862 1199 1738 2601 2555 1517 1808 1194 1601 2574 1654 M13001 GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. 17/48 Gene Ontology BP GO:2000171 2.39066222450139e-06 4.743523379641e-06 2895 1865.90909090909 1812 2.17333165668497e-07 240 2.05145779375084 2.34668652663703 1 10.13821562927 2891 839 1659 1210 2265 3531 2137 1083 240 1812 2858 1655 M15287 GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 13/42 Gene Ontology BP GO:0071392 7.18974119082816e-07 1.6641060991533e-06 1815 1872.72727272727 1812 6.53613049134799e-08 926 2.38754972304258 2.30304869382145 1 12.8073904978875 1812 2632 1045 2042 1938 1488 926 2820 2967 1786 1144 1656 M14450 GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. 10/23 Gene Ontology BP GO:0042402 2.86681994666837e-05 4.59146085283933e-05 910 1740.54545454545 1813 2.60623391352722e-06 574 1.5877899564779 -1.5877899564779 -1 6.39376461187236 906 1915 1813 2353 2797 574 1350 1305 2400 2486 1247 1657 M11852 GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. 5/16 Gene Ontology BP GO:0048712 1.15617294776956e-05 1.98304802234728e-05 1535 1860.18181818182 1814 1.15617896312509e-06 221 3.27803121667969 3.27803121667969 1 14.3095648370516 1534 2498 3816 2249 3332 1814 1478 618 221 2272 630 1658 M15199 GO_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 10/23 Gene Ontology BP GO:0009310 2.86681994666837e-05 4.59146085283933e-05 910 1739.81818181818 1814 2.60623391352722e-06 575 1.5877899564779 -1.5877899564779 -1 6.39376461187236 907 1916 1814 2354 2798 575 1351 1284 2401 2490 1248 1659 M10231 GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 3/16 Gene Ontology BP GO:0072216 0.000131847701401966 0.000190944752841338 1635 2044.45454545455 1815 1.31855524772618e-05 1182 2.60608537702205 2.60608537702205 1 8.99693794934802 1631 1936 3557 2400 3089 1393 1182 1763 1968 1755 1815 1660 M11947 GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT.html The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. 66/243 Gene Ontology BP GO:0015850 4.54689694045668e-09 4.52060867120778e-08 1815 1810.54545454545 1815 4.13354268168552e-10 284 2.00106579901436 2.18585493592471 1 13.6430245921327 1815 327 284 938 1629 3660 1923 4229 1993 605 2513 1661 M13122 GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 13/35 Gene Ontology BP GO:0040036 2.49349009110387e-08 1.20220918930377e-07 4030 2080.72727272727 1816 2.26680919942292e-09 550 1.64050634479638 1.02005871394933 1 10.5379078173803 4028 2242 1816 1531 845 3807 2522 550 797 1784 2966 1662 M10138 GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. 8/30 Gene Ontology BP GO:0019682 1.00445822123833e-06 2.22504748149312e-06 565 1839.45454545455 1817 1.00445867525997e-07 76 1.01745125733795 -1.01745125733795 -1 5.33870172749474 565 1817 3540 2432 2930 364 76 1192 3413 2901 1004 1663 M16471 GO_BILE_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 18/68 Gene Ontology BP GO:0008206 4.64268246567035e-07 1.14173594746332e-06 4510 2498.09090909091 1817 4.22062131401878e-08 859 1.85534390658639 -1.33398856712729 -1 10.2342953605938 4509 1067 1170 906 1817 3376 4561 4090 859 1486 3638 1664 M14676 GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. 6/23 Gene Ontology BP GO:1902259 3.83137037964248e-06 7.23720613209115e-06 1190 2017.27272727273 1820 3.83137698538806e-07 601 1.12637949033363 1.07982547196804 1 5.37468764233463 1186 1820 4271 2635 2398 934 601 2054 3549 1734 1008 1665 M15038 GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. 22/69 Gene Ontology BP GO:0048483 1.81194980551248e-06 3.73184943969141e-06 1830 1616.90909090909 1827 1.64722845260056e-07 455 1.85565035122535 -0.950579733339013 -1 9.3499909717936 1827 950 791 1143 2179 2840 2479 1923 455 1204 1995 1666 M15783 GO_RESPONSE_TO_CYTOKINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CYTOKINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 393/1023 Gene Ontology BP GO:0034097 1.64442373676066e-08 9.14378372428713e-08 1720 1811.54545454545 1828 1.49493068095651e-09 573 1.70883856366852 2.01517612370501 1 11.1653763175275 1717 1828 573 2087 681 4117 2105 1173 2107 1190 2349 1667 M15697 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction. 45/122 Gene Ontology BP GO:0055117 2.65882509654732e-05 4.28494443709449e-05 1040 2076.18181818182 1830 2.41714293682198e-06 1037 1.92927198393192 1.8710569106091 1 7.82259178172986 1037 3716 1514 1830 2782 1407 1217 3559 2360 2121 1295 1668 M14456 GO_MONOCARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSPORT.html The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 53/209 Gene Ontology BP GO:0015718 1.13020419206237e-05 1.94137553227731e-05 1030 1762.72727272727 1831 1.02746363481167e-06 681 1.90837370796213 2.07640388104706 1 8.34694863032195 1030 1220 681 2188 2614 2326 1831 2113 2682 894 1811 1669 M15174 GO_VISUAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VISUAL_BEHAVIOR.html The behavior of an organism in response to a visual stimulus. 26/78 Gene Ontology BP GO:0007632 2.44549110978193e-06 4.83990418700661e-06 1625 1942 1832 2.22317620741997e-07 973 1.21611205028503 1.13708415156992 1 6.00011157228246 1624 1541 2572 1832 2268 1392 973 2141 1559 3243 2217 1670 M15756 GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. 25/50 Gene Ontology BP GO:1904837 3.35354637580904e-06 6.40761968019809e-06 3270 1980.90909090909 1832 3.04868317069305e-07 379 1.51773204239455 -1.459285773259 -1 7.31657650387705 3269 379 1832 1581 2349 1213 2847 2962 1281 1156 2921 1671 M10641 GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. 23/66 Gene Ontology BP GO:2000351 2.5676811872889e-09 3.41694701612955e-08 1900 1550.81818181818 1833 2.33425562753247e-10 70 1.76327801093903 2.05649889504009 1 12.2207808151558 1899 678 862 804 70 2876 1833 2298 2008 739 2992 1672 M14701 GO_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGING.html An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). 53/113 Gene Ontology BP GO:0007569 4.73891333438188e-07 1.16293734733272e-06 1835 1861.90909090909 1833 4.30810395924413e-08 420 1.57061402796663 2.10606843588486 1 8.65204195627348 1833 2040 1769 1296 1823 3490 2151 420 1320 2405 1934 1673 M13027 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION.html Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. 11/34 Gene Ontology BP GO:0060142 5.45273398808509e-07 1.3097280862224e-06 770 1777.36363636364 1835 4.95703212686737e-08 54 1.64757127315458 1.64757127315458 1 8.99702276716867 768 2479 1835 3203 3835 375 54 489 3418 2660 435 1674 M14927 GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. 62/168 Gene Ontology BP GO:0055067 2.75663763628151e-06 5.38454713725497e-06 2430 2027.72727272727 1836 2.50603735491063e-07 1387 1.7286905320585 -1.68131815028628 -1 8.45477952942027 2429 1983 1387 1634 2302 1572 3763 1836 2272 1393 1734 1675 M15668 GO_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_RESORPTION.html The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. 16/39 Gene Ontology BP GO:0045453 3.09955219614995e-07 8.15828846186179e-07 3030 2143.36363636364 1836 2.81777512076548e-08 1085 1.77855186380391 1.97399244490532 1 10.0516859678614 3027 1085 1780 2208 1692 3732 2407 1176 1836 1270 3364 1676 M11653 GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. 28/52 Gene Ontology BP GO:0008154 9.91254097056004e-06 1.71923525313075e-05 3185 2282.36363636364 1837 9.01144148525636e-07 1206 1.71823044574479 -1.96652045291326 -1 7.5994626315486 3183 1603 1467 1439 2592 3560 1837 2318 1206 1404 4497 1677 M12052 GO_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. 43/117 Gene Ontology BP GO:0030183 6.30057946445028e-08 2.30162001994041e-07 3145 2167.27272727273 1837 5.72779967717507e-09 1004 2.04056592205052 -1.22964269650068 -1 12.5734602400314 3145 1837 1513 1004 1174 3679 4138 1411 1328 2327 2284 1678 M12216 GO_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_DEVELOPMENT.html The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 45/114 Gene Ontology BP GO:0001892 1.21435497523285e-09 1.96454709059447e-08 3840 2143.63636363636 1837 1.10395906900287e-10 13 1.81097002392999 1.49779486001176 1 12.9554041933153 3838 523 884 1028 13 3946 3385 2904 1096 1837 4126 1679 M12663 GO_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a lymphocyte. 63/369 Gene Ontology BP GO:0002449 1.60795606988642e-09 2.44778361720743e-08 2215 1942.81818181818 1838 1.46177824641969e-10 30 1.49847663029496 -0.991660597752134 -1 10.587021168777 2211 2171 1805 2551 30 3475 1838 1488 2447 1635 1720 1680 M11863 GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. 20/49 Gene Ontology BP GO:0051058 1.02467951765406e-07 3.33590875077534e-07 1955 1980.63636363636 1839 9.31526877618085e-09 902 1.15592437356075 1.29299385324552 1 6.94957246209404 902 1954 2373 1955 1342 1839 1449 1527 3518 3159 1769 1681 M10494 GO_ENDOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. 40/73 Gene Ontology BP GO:0007032 4.03410522000538e-08 1.68438404105081e-07 1660 2256.54545454545 1840 3.66736844907102e-09 527 1.00748716482691 -0.749987927004681 -1 6.33469283008112 1656 1840 2854 3947 1007 527 1392 2738 3777 3482 1602 1682 M12897 GO_RESPONSE_TO_GROWTH_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 15/67 Gene Ontology BP GO:0060416 4.62532424827597e-07 1.13867340852308e-06 3415 2186.72727272727 1840 4.20484110973975e-08 963 1.68914925396463 -2.14667357442159 -1 9.31937510633735 3414 963 1655 1673 1815 2589 4254 1840 1445 2040 2366 1683 M14526 GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 71/175 Gene Ontology BP GO:0090263 2.78085856844358e-05 4.46302327455359e-05 2030 1911.81818181818 1840 2.52808519987115e-06 401 2.15896778986806 2.58634034621473 1 8.71849605146421 2026 2122 1357 972 2792 4359 2838 892 401 1431 1840 1684 M11113 GO_FERRIC_IRON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERRIC_IRON_TRANSPORT.html The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/44 Gene Ontology BP GO:0015682 5.31897892617474e-06 9.77286076542514e-06 675 1623.18181818182 1841 4.83544707818885e-07 414 1.61455973800306 -1.45083655917166 -1 7.50860213541035 673 2268 2200 1841 2448 414 1000 1255 2311 2556 889 1685 M14459 GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. 35/106 Gene Ontology BP GO:0046888 1.45109136505888e-05 2.44197796591822e-05 1845 2014.72727272727 1841 1.31918266941548e-06 652 1.61714554774678 1.63643087497634 1 6.923598195903 652 2684 1483 4385 2666 1016 755 1841 3447 1391 1842 1686 M14968 GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a humoral immune response. 18/65 Gene Ontology BP GO:0002920 4.10113611881139e-07 1.03094612883819e-06 1780 1996 1842 3.72830625756911e-08 1346 1.96428896052224 1.8663939963035 1 10.9160785095533 1778 2094 1579 2963 1775 1799 1346 2160 1842 1936 2684 1687 M16469 GO_TRIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 19/44 Gene Ontology BP GO:0072512 5.31897892617474e-06 9.77286076542514e-06 675 1621.09090909091 1842 4.83544707818885e-07 415 1.61455973800306 -1.45083655917166 -1 7.50860213541035 674 2269 2201 1842 2449 415 1001 1220 2312 2559 890 1688 M13899 GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. 72/173 Gene Ontology BP GO:0006367 3.16169877109952e-07 8.30303585645648e-07 1705 2079.90909090909 1844 2.87427202316241e-08 181 1.44096785399712 -1.44090183251788 -1 8.13357558512019 1844 3712 2965 3630 1701 181 1705 1167 1971 3497 506 1689 M15840 GO_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTION.html The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. 627/2036 Gene Ontology BP GO:0000003 4.53821679243371e-09 4.52060867120778e-08 1505 2117.81818181818 1844 4.53821680170165e-10 236 1.87571136288864 2.03737186954174 1 12.7883731952643 1503 3286 4465 2497 236 3670 1621 1844 2029 650 1495 1690 M15876 GO_PLATELET_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DEGRANULATION.html The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. 62/171 Gene Ontology BP GO:0002576 1.19136321174117e-06 2.59208031495512e-06 510 1757.72727272727 1844 1.08305805172642e-07 508 1.92759190277493 2.06123161224365 1 9.99568332764084 508 3201 759 3196 2060 1119 748 1967 2741 1192 1844 1691 M16863 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. 5/15 Gene Ontology BP GO:0043568 2.59277488842528e-07 7.07300458693219e-07 1560 1965.54545454545 1844 2.59277519093701e-08 187 2.99296293357553 2.99296293357553 1 17.0873045052116 1557 1826 4626 1844 2646 2108 2076 187 266 3296 1189 1692 M16440 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. 39/112 Gene Ontology BP GO:1901019 2.73299460241374e-08 1.28555726231123e-07 2010 1665.18181818182 1845 2.48454057851357e-09 481 1.93513595045147 -1.47051447853671 -1 12.3781888473562 1966 1300 1322 481 869 3012 2009 2010 1123 2380 1845 1693 M13852 GO_DICARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSPORT.html The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/107 Gene Ontology BP GO:0006835 2.98229241983334e-07 7.90675968926134e-07 3315 2418.72727272727 1847 2.71117529464477e-08 616 2.28624009171592 2.62100265341407 1 12.9498064962467 3312 1847 834 1262 1679 4230 4252 4289 616 844 3441 1694 M10200 GO_N_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_GLYCAN_PROCESSING.html The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. 11/20 Gene Ontology BP GO:0006491 9.92836943838196e-09 6.84092423094333e-08 1500 2037.72727272727 1848 9.02579043926153e-10 475 1.10676923082449 1.3181025877512 1 7.36097672544359 1496 2067 2438 3026 475 1848 1292 809 4135 3309 1520 1695 M14335 GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 10/39 Gene Ontology BP GO:0051350 5.18524879412844e-06 9.54225531158873e-06 1630 1976.81818181818 1848 4.71387365040345e-07 683 1.8317218044671 1.92335835336095 1 8.5361601286769 1627 3060 1848 3081 2444 1348 683 1731 1997 2485 1441 1696 M15744 GO_NEUROMUSCULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS.html Any process pertaining to the functions of the nervous and muscular systems of an organism. 41/199 Gene Ontology BP GO:0050905 1.3943465872139e-06 2.97264891841915e-06 1485 1801.45454545455 1849 1.26758860994823e-07 1208 1.81781169532958 2.10894087385088 1 9.32601705170369 1485 1993 1208 1554 2109 2273 1866 1517 1849 2174 1788 1697 M10753 GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. 20/36 Gene Ontology BP GO:0045932 5.89375804836843e-08 2.20861328640634e-07 2755 2200.63636363636 1851 5.3579620056919e-09 1145 1.99808761099928 1.80445873415474 1 12.3449451972424 1851 2753 1426 2671 1145 2751 1543 4211 2372 1708 1776 1698 M12654 GO_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. 79/246 Gene Ontology BP GO:0048469 2.25246289840793e-08 1.12118515518463e-07 1360 1813.54545454545 1851 2.04769356497246e-09 795 1.80148063438158 1.89877452154311 1 11.6226109111864 1359 3232 795 2335 802 1851 1479 2816 2499 909 1872 1699 M13643 GO_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 55/151 Gene Ontology BP GO:0007219 5.23562469307152e-07 1.2628054779185e-06 2910 2341.81818181818 1851 4.75965994460118e-08 1065 1.56008331846509 -1.10346806224435 -1 8.54221601975622 2906 1777 1650 1065 1851 4589 2821 3036 1145 1693 3227 1700 M15793 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 10/22 Gene Ontology BP GO:0061003 6.64031879416561e-06 1.19222738442811e-05 485 1634.09090909091 1851 6.0366716699109e-07 381 1.8265901694133 1.8265901694133 1 8.34827254322506 482 2598 2234 2685 3038 697 381 513 1851 2499 997 1701 M14597 GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS.html A biological process that directly contributes to the process of producing new individuals, involving another organism. 405/1478 Gene Ontology BP GO:0044703 1.45347153791338e-08 8.59677496883038e-08 1830 1817.18181818182 1852 1.3213377704691e-09 384 1.86457627284437 2.03797008716447 1 12.229319650214 1826 3361 384 1903 628 4286 2138 1852 1964 1045 602 1702 M15414 GO_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_INVAGINATION.html The infolding of a membrane, resulting in formation of a vesicle. 26/170 Gene Ontology BP GO:0010324 7.27452110703458e-07 1.68121460925642e-06 2630 1938.27272727273 1855 6.61320319311747e-08 819 1.58528778028772 1.87067323249061 1 8.4973276973587 2629 819 1694 1597 1940 2583 1855 2466 947 1579 3212 1703 M15018 GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 33/83 Gene Ontology BP GO:0050810 8.79724830335743e-08 2.96233439482718e-07 3960 2287.36363636364 1856 7.99749877739762e-09 155 1.767330557381 1.76983323099286 1 10.7100478068395 3960 155 1200 738 1292 4021 3842 4127 789 1856 3181 1704 M15552 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 52/127 Gene Ontology BP GO:0051279 2.77834655777312e-08 1.2977729444407e-07 2230 1756.36363636364 1857 2.52576962987312e-09 517 1.66471155355048 -1.25346164068692 -1 10.6420594172232 2228 517 1688 1007 878 3448 1876 1857 2090 1768 1963 1705 M16903 GO_PIGMENT_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_METABOLIC_PROCESS.html The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. 33/73 Gene Ontology BP GO:0042440 3.37109478561032e-08 1.48079404821085e-07 4210 2263.54545454545 1857 3.06463167024195e-09 366 1.48053909207531 -1.08788434297605 -1 9.38595052648091 4208 366 1633 919 950 2029 3701 4115 563 1857 4558 1706 M16198 GO_ENDOTHELIAL_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 8/17 Gene Ontology BP GO:0061154 2.0944884222184e-06 4.20871810747616e-06 1215 2188.45454545455 1858 2.09449039631781e-07 208 3.57280298356418 3.57280298356418 1 17.8289333319505 1213 4393 4527 1343 4091 2181 1858 368 208 2943 948 1707 M10730 GO_NADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. 12/41 Gene Ontology BP GO:0006739 6.83226020040547e-05 0.000102594385868314 1095 1953.36363636364 1861 6.21133853676982e-06 557 0.880041728660196 -0.833070999315003 -1 3.25853927833773 1091 1861 2495 2636 2971 557 772 1512 3613 2793 1186 1708 M11245 GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 22/69 Gene Ontology BP GO:0051349 4.43685921444855e-08 1.81340997646871e-07 3645 2425.81818181818 1861 4.03350845811735e-09 682 1.71673382520285 -1.64726197461862 -1 10.7430821014123 3644 682 1296 1106 1032 4532 3154 3635 1861 1198 4544 1709 M16062 GO_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_NUCLEUS.html A process in which a protein is transported to, or maintained in, a location within the nucleus. 89/234 Gene Ontology BP GO:0034504 2.22261519117242e-06 4.44044850800928e-06 1635 1973.54545454545 1863 2.02056130603496e-07 398 1.76954107819443 2.43830931450687 1 8.79209542717459 1632 3442 1863 2765 2247 2482 1385 398 1483 3136 876 1710 M11612 GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 23/61 Gene Ontology BP GO:0010591 1.8714214876272e-05 3.0920757601675e-05 1015 1857.90909090909 1864 1.70130673362841e-06 377 1.65244242138897 1.75273374861049 1 6.91748012722972 1011 3445 2352 1864 2720 1132 377 1318 1902 2992 1324 1711 M11515 GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein oligomerization. 10/25 Gene Ontology BP GO:0032461 9.7932564916256e-08 3.22254357835703e-07 2675 1772.09090909091 1865 8.90296084324589e-09 106 2.43855845894386 3.3442451928568 1 14.6949299253787 2671 1966 1380 1345 1540 3427 2027 106 960 1865 2206 1712 M10877 GO_MODIFIED_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSPORT.html The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/36 Gene Ontology BP GO:0072337 4.76908349814457e-06 8.81132299318951e-06 4095 2370.72727272727 1866 4.33553985129938e-07 1153 2.00982759635124 -2.35322786566661 -1 9.43073550955251 4092 1619 1293 1866 2427 3273 4616 1153 1532 1162 3045 1713 M16618 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM.html Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. 19/56 Gene Ontology BP GO:0010880 5.28698739675787e-05 8.07482976419302e-05 930 1769.63636363636 1868 4.80646768786338e-06 651 1.63706542580651 1.93982575682222 1 6.21960432519612 926 2473 2212 2165 2934 844 741 1868 1619 3033 651 1714 M10430 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. 13/45 Gene Ontology BP GO:0045956 2.14001532458619e-07 5.97901205650516e-07 1965 1968.45454545455 1869 1.94546866613894e-08 648 1.6044729831066 1.68845098663256 1 9.2688787959309 1964 1690 1745 1869 1589 2594 1965 4040 648 1285 2264 1715 M13782 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. 11/24 Gene Ontology BP GO:1901018 3.7257076439639e-07 9.52558402583941e-07 1870 1991 1869 3.38700752264903e-08 1168 1.56663032336533 -2.00601719097705 -1 8.75612808202779 1869 1168 1597 2109 1742 2142 1494 3790 2580 1451 1959 1716 M12226 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 38/71 Gene Ontology BP GO:1902041 2.53571718777806e-08 1.21690920089996e-07 3670 2206.45454545455 1870 2.30519747000428e-09 529 1.54639334699322 -1.20858511551966 -1 9.92578983696166 3669 529 1437 1238 848 3507 3297 2655 1870 1049 4172 1717 M14995 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. 22/54 Gene Ontology BP GO:0030837 5.76662513850149e-07 1.37799487998263e-06 1440 1957.36363636364 1870 5.24238786367811e-08 387 1.56013076701274 1.54963705753205 1 8.48757269854822 2267 387 1664 1438 1870 2579 1440 4473 392 2400 2621 1718 M14062 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 31/74 Gene Ontology BP GO:0010524 7.26894566734658e-10 1.26878626817632e-08 3685 2088.09090909091 1871 6.60813242704392e-11 3 1.66962165189898 -1.41796687981325 -1 12.2384939289662 3685 368 1456 1280 3 3733 3377 1908 1871 1052 4236 1719 M16394 GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. 11/24 Gene Ontology BP GO:0030826 5.82957431534717e-07 1.39004142904211e-06 4300 2311.72727272727 1873 5.29961441824739e-08 758 2.07512014442828 -1.70006346559692 -1 11.2819857689483 4299 1333 987 918 1873 4499 3244 2402 758 1011 4105 1720 M16581 GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 76/177 Gene Ontology BP GO:0034614 3.26001891436331e-07 8.51528994692558e-07 1515 1933.09090909091 1874 2.9636539976743e-08 962 1.64833333337933 2.00861115434646 1 9.2872811996558 1515 2417 1431 1785 1709 2720 1874 962 2288 2686 1877 1721 M16401 GO_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. 9/19 Gene Ontology BP GO:0070231 5.37235318308521e-07 1.29242672689454e-06 2095 2021.90909090909 1876 5.37235448188369e-08 266 1.41503271879071 1.64121557982386 1 7.73476689736112 2095 1487 4559 1831 1876 2864 2380 266 1518 2371 994 1722 M10045 GO_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_RHYTHM.html Any biological process in an organism that recurs with a regularity of approximately 24 hours. 68/192 Gene Ontology BP GO:0007623 2.5397797758233e-08 1.21690920089996e-07 2030 1979.18181818182 1878 2.30889073194879e-09 850 1.84327378572844 2.17523152880643 1 11.8313676822413 2027 1721 906 1878 850 3789 2314 2661 1837 1989 1799 1723 M14611 GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. 10/28 Gene Ontology BP GO:0031146 8.22621646434449e-06 1.45170365047326e-05 1090 1776.18181818182 1878 7.47840656716919e-07 554 1.30558918935981 -1.30558918935981 -1 5.86344007252302 1087 2480 2274 2305 2543 554 1675 1529 1979 1878 1234 1724 M12385 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE.html A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 6/15 Gene Ontology BP GO:0033540 3.70167806250113e-06 7.01792210869446e-06 1320 1859.45454545455 1879 3.7016842286048e-07 396 0.839446336068759 -0.839446336068759 -1 4.01595556909387 1318 1879 3900 1919 2509 396 526 447 3451 3426 683 1725 M14708 GO_GLUTATHIONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. 34/71 Gene Ontology BP GO:0006749 5.91755594375335e-07 1.40682090357639e-06 1085 2050.09090909091 1879 5.37959775950641e-08 842 1.3924510414664 -1.29823257609238 -1 7.56372375414862 1085 2881 2073 3946 1879 842 1604 2040 3397 1587 1217 1726 M15521 GO_REGULATION_OF_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. 17/43 Gene Ontology BP GO:0098801 1.18573395356572e-05 2.03000101268645e-05 1170 1854.90909090909 1879 1.07794576760362e-06 809 2.53242189174257 2.31572912995271 1 11.0308713946647 1170 2428 809 1879 2623 1738 1505 2638 2013 1383 2218 1727 M15806 GO_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLIC_PROCESS.html The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. 21/78 Gene Ontology BP GO:0019748 7.36586653306656e-09 5.84610569453471e-08 1880 1903.72727272727 1879 6.69624232520763e-10 357 2.02639138728957 2.25963409841927 1 13.6056388155723 1879 1905 1036 1054 357 3256 2179 4355 700 1833 2387 1728 M12557 GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. 22/42 Gene Ontology BP GO:2000279 0.000708899725717406 0.00094581075474308 1565 2026.09090909091 1881 6.4466205050441e-05 1282 2.090143669065 2.30663522223329 1 5.86752792476506 1565 3396 1410 1881 3370 1979 1546 1282 1932 2396 1530 1729 M10304 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. 13/25 Gene Ontology BP GO:1900015 3.19666491956211e-06 6.15599967711608e-06 1885 2022.18181818182 1882 2.90606324038183e-07 1283 2.17951198590086 2.85223518993415 1 10.5420381393527 1882 1812 1509 1283 2335 3130 2175 1851 1367 2952 1948 1730 M10720 GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 28/91 Gene Ontology BP GO:0048168 1.19963762752281e-08 7.61958618958744e-08 2320 1800.36363636364 1883 1.0905796673312e-09 555 1.75149344758283 2.01977760187032 1 11.5728366087009 2318 1998 1692 1155 555 3086 1232 1883 598 2115 3172 1731 M16433 GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION.html The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. 10/22 Gene Ontology BP GO:0060900 8.11195982534432e-07 1.84807799161304e-06 1920 1940.45454545455 1883 7.37451165130169e-08 1210 1.40242558562921 -1.31458051140505 -1 7.46366411243244 1919 1868 1772 1924 1969 1210 2448 1767 2840 1883 1745 1732 M12473 GO_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BUDDING.html The evagination of a membrane, resulting in formation of a vesicle. 82/170 Gene Ontology BP GO:0006900 6.66277996850026e-09 5.50177850965416e-08 2920 1979.54545454545 1884 6.05707271698068e-10 328 1.53313975804316 -1.04454491467807 -1 10.3313578302652 2918 498 1828 1884 328 872 3263 3702 1531 2513 2438 1733 M11195 GO_VESICLE_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_TARGETING.html The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. 62/125 Gene Ontology BP GO:0006903 2.56598839283794e-08 1.22319138685283e-07 4350 2299.81818181818 1887 2.3327167479696e-09 643 1.74013956580959 -1.09101148720545 -1 11.1657708637451 4349 643 1588 1341 855 2729 4575 2104 663 1887 4564 1734 M10588 GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. 20/54 Gene Ontology BP GO:0030517 0.00158651645613043 0.00204901137852951 1275 2000.27272727273 1888 0.000144332883557428 1273 2.24145130926632 2.54176766447632 1 5.59372754034064 1273 2885 1320 1912 3407 2462 1427 2091 1888 1707 1631 1735 M11936 GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 48/142 Gene Ontology BP GO:0019217 1.62823278638264e-06 3.40842417816709e-06 1580 1997.54545454545 1888 1.48021271949858e-07 1442 1.57663494341019 1.83190790246336 1 8.00174689641433 1577 1895 1888 1607 2143 3200 1797 1548 2490 2386 1442 1736 M10998 GO_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. 75/161 Gene Ontology BP GO:0002573 4.25200574473459e-08 1.75797530479098e-07 1325 2063.81818181818 1889 3.86545984264944e-09 975 1.67457466536376 2.07201015849226 1 10.50021478158 1322 3975 1889 3019 1019 2195 1289 975 2384 2898 1737 1737 M12755 GO_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE.html An immune response mediated through a body fluid. 76/484 Gene Ontology BP GO:0006959 2.68111399744751e-07 7.25431951640372e-07 3340 2098.27272727273 1889 2.43737665835614e-08 244 1.96708581805295 -1.71586411782583 -1 11.2103353997379 3339 1889 397 1691 1651 1766 3622 3554 2302 244 2626 1738 M14864 GO_ERROR_PRONE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_PRONE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 8/25 Gene Ontology BP GO:0042276 0.000196733476460531 0.00027985095931564 1430 2218.18181818182 1889 1.96750895458283e-05 1054 1.24678748764606 -1.24678748764606 -1 4.11211934673559 1430 2805 4307 2130 3546 1365 1889 1054 1814 2934 1126 1739 M15960 GO_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REPOLARIZATION.html The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. 11/28 Gene Ontology BP GO:0086009 4.45749976994473e-07 1.10438481493348e-06 2075 1780.45454545455 1890 4.05227333917744e-08 1007 2.15273638046621 1.75494108714709 1 11.9036131756754 2072 1815 1224 1908 1799 2265 2052 1385 2168 1007 1890 1740 M13516 GO_PIGMENT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. 19/41 Gene Ontology BP GO:0050931 6.22473308427387e-07 1.47081097762257e-06 3585 2254.90909090909 1891 5.65884985955961e-08 128 1.95195764132421 -1.60534989797744 -1 10.5679326354854 3585 553 1083 841 1891 4347 2849 3395 128 1590 4542 1741 M10755 GO_TRANSITION_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSPORT.html The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 46/122 Gene Ontology BP GO:0000041 6.32259868989605e-07 1.49241615237353e-06 865 1643.72727272727 1893 5.74781864268527e-08 391 1.37333990974169 -1.2943252536322 -1 7.42721260460921 862 1987 2448 2500 1893 391 1159 1188 2817 1918 918 1742 M13307 GO_CELL_DIFFERENTIATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_HINDBRAIN.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. 14/41 Gene Ontology BP GO:0021533 6.96598762437419e-05 0.000104399872627403 1955 1895.09090909091 1894 6.33291654750859e-06 710 1.90823768743474 -2.03737497675198 -1 7.05223061694328 1952 2148 1381 1596 2978 1692 2329 3144 1894 1022 710 1743 M13532 GO_TETRAPYRROLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 32/86 Gene Ontology BP GO:0033013 2.9786900698937e-06 5.7842149705213e-06 3745 2200.63636363636 1895 2.70790372990805e-07 565 1.56822512386234 -0.896125662116222 -1 7.62470008677175 3742 1671 1895 1398 2318 3043 3921 1093 565 1430 3131 1744 M15643 GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. 22/31 Gene Ontology BP GO:0046827 6.93604396606494e-06 1.24148234905318e-05 655 2070.81818181818 1895 6.30551439432278e-07 519 1.63802903814092 1.79444824173571 1 7.45973729438737 651 3691 2225 3811 2816 1250 1007 519 1895 3339 1575 1745 M14180 GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 42/97 Gene Ontology BP GO:0009124 5.95875464388131e-06 1.08368577405174e-05 1180 2416.09090909091 1896 5.41706434852497e-07 992 0.854738098317738 -0.895362824310226 -1 3.93939824324899 1179 1896 3035 3790 2471 992 1739 1799 3852 3958 1866 1746 M11291 GO_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. 14/27 Gene Ontology BP GO:0055075 6.48623405078845e-08 2.34362526831212e-07 3850 2145.90909090909 1897 5.89657658365575e-09 293 2.26482186220432 -2.70003676520157 -1 13.9387567161958 3850 2660 1722 1525 1184 3751 4023 293 587 1897 2113 1747 M11627 GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. 14/44 Gene Ontology BP GO:0045746 1.5235931511858e-06 3.21547409134348e-06 4150 2317.09090909091 1898 1.3850856421269e-07 952 2.32048955427425 -1.41317854018237 -1 11.8314774268147 4147 1091 952 1363 2127 3868 4362 1117 1030 1898 3533 1748 M12209 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 14/30 Gene Ontology BP GO:0010523 5.96453811901339e-08 2.22615357609157e-07 2275 1802.45454545455 1899 5.42230752792835e-09 416 1.75711540820918 -1.62183452658305 -1 10.8505238499712 2271 416 1124 728 1150 3547 2533 2617 1490 1899 2052 1749 M13571 GO_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_HOST.html An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 86/213 Gene Ontology BP GO:0051701 2.18512779941609e-08 1.09641784421907e-07 1585 2014.90909090909 1899 1.9864798373815e-09 789 1.63600281521473 2.00509281201604 1 10.5697304436352 1583 1886 1301 2123 789 3576 1899 2166 2824 2220 1797 1750 M15630 GO_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 937/2497 Gene Ontology BP GO:0051049 4.82564566957969e-09 4.65403570179007e-08 1815 2097.54545454545 1899 4.82564568005877e-10 72 1.66168638976767 1.95191851503316 1 11.3096910163033 1813 1196 4433 1390 624 4580 2292 1899 2183 72 2591 1751 M12677 GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. 29/63 Gene Ontology BP GO:0009201 7.54987733115143e-05 0.000112822917439769 595 2043.36363636364 1900 6.86376039768495e-06 591 0.930783146117217 -0.907035632474027 -1 3.41075921863084 591 1900 3183 2831 2987 634 1017 1053 3246 3766 1269 1752 M13416 GO_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_URINE_VOLUME.html Any process that modulates the amount of urine excreted from the body over a unit of time. 14/30 Gene Ontology BP GO:0035809 2.28327206168469e-05 3.72103621705933e-05 1460 1939.18181818182 1901 2.07572341726318e-06 929 2.01500089201482 1.89803055416777 1 8.28481872972817 1457 1557 929 1551 2757 2423 2139 2287 1740 1901 2590 1753 M13589 GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT.html The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 12/29 Gene Ontology BP GO:0034219 0.000238454450217234 0.000335498185563217 1085 1887.09090909091 1903 2.168002725754e-05 1082 1.93901018554944 1.93901018554944 1 6.25342237007001 1082 2102 1703 1478 3165 1903 1199 1783 2094 2182 2067 1754 M13777 GO_LONG_TERM_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_MEMORY.html The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. 14/45 Gene Ontology BP GO:0007616 8.62022931223303e-08 2.9192572985443e-07 3345 2273.90909090909 1903 7.83657240908938e-09 309 2.1495726655183 2.20777846583863 1 13.0391342478792 3341 1245 1452 997 1285 4007 3181 3738 309 1903 3555 1755 M12857 GO_POSITIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_GROWTH.html Any process that activates or increases the frequency, rate, extent or direction of cell growth. 103/233 Gene Ontology BP GO:0030307 1.91614640872361e-07 5.45473192869634e-07 1560 1956.72727272727 1904 1.74195143237756e-08 1062 1.96008999359775 2.28249444493043 1 11.3957593572125 1904 1885 1071 2089 1559 3551 2626 1558 1930 1062 2289 1756 M11738 GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. 98/242 Gene Ontology BP GO:0043409 1.5645978785883e-08 8.86167057924368e-08 665 1738.09090909091 1905 1.42236171792311e-09 661 1.56033863435807 1.77750811681067 1 10.2148061553819 1538 2120 2185 2093 664 1905 1085 661 2003 3104 1761 1757 M12619 GO_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYMERIZATION.html The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. 43/96 Gene Ontology BP GO:0051258 6.58577810468865e-07 1.54355213225994e-06 4320 2183.09090909091 1906 5.98707279651411e-08 658 1.70818925949453 -1.63851237885076 -1 9.21492425435886 4316 658 1341 1261 1906 2510 4053 2086 1132 1186 3565 1758 M15642 GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that modulates the frequency, rate or extent of response to oxidative stress. 36/89 Gene Ontology BP GO:1902882 2.44826617028988e-08 1.19029317577549e-07 1745 1834.27272727273 1906 2.22569654321397e-09 835 1.59123376544991 1.9092681383263 1 10.2277919164896 1744 2682 2050 2182 835 1906 1076 1608 2142 2453 1499 1759 M14491 GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE.html The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. 2/15 Gene Ontology BP GO:0007342 0.0032724439663717 0.00409540628999025 1630 2260.9 1909 0.000364134811408579 1340 2.15299742448331 -2.15299742448331 -1 4.77191765008784 1628 2251 4244 NA 3531 1340 1443 1801 2989 1365 2017 1760 M15102 GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 6/15 Gene Ontology BP GO:0009143 2.63397662613513e-07 7.16016011425375e-07 2740 2221.09090909091 1909 2.63397693833766e-08 305 2.0989141287978 -0.961233989738545 -1 11.9726738999071 2738 1880 4353 1909 1673 3575 2625 1098 305 1738 2538 1761 M16316 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. 10/23 Gene Ontology BP GO:0002888 2.18494832555069e-07 6.0892647512196e-07 1980 1876.90909090909 1910 1.98631685686426e-08 1256 1.47389334409976 1.9227889004926 1 8.50367646625835 1980 1256 2211 2001 1595 2620 1910 1613 1560 2501 1399 1762 M13653 GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. 12/31 Gene Ontology BP GO:0045879 0.000166806305829761 0.000239333027802095 1485 1872.54545454545 1911 1.51653595092164e-05 1033 1.51648831580393 1.79097886318841 1 5.09725548844029 1481 1911 1975 2200 3114 1925 1870 1033 1310 2183 1596 1763 M14277 GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 27/56 Gene Ontology BP GO:0051353 6.67525678567032e-07 1.56025603911877e-06 3630 2525.63636363636 1911 6.06841710098426e-08 1013 1.9673067727944 -1.5805499800682 -1 10.6042119090558 3629 1675 1013 1429 1911 4398 3215 3838 1296 1035 4343 1764 M15725 GO_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_NUCLEATION.html The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. 13/25 Gene Ontology BP GO:0045010 1.59467497325638e-07 4.74930230104745e-07 1915 1651.36363636364 1911 1.44970462622434e-08 140 1.59684261466354 -1.63901474619286 -1 9.37302669848211 1911 702 1915 1441 2158 2042 3750 140 1125 2318 663 1765 M10714 GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. 25/77 Gene Ontology BP GO:0002286 6.29225586502556e-08 2.30162001994041e-07 3095 2403.27272727273 1912 5.72023276817401e-09 1172 1.86681825077107 2.14947442119842 1 11.5028702392642 3092 1799 1700 2237 1172 4526 3588 1644 1912 1461 3305 1766 M16375 GO_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_MATURATION.html Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 12/23 Gene Ontology BP GO:0090128 2.15371141044142e-05 3.52473813136394e-05 1980 1835 1912 1.95793863154349e-06 690 2.05722597289579 2.01639867991122 1 8.50337737750358 1977 1912 1853 1631 2865 1941 780 690 877 2815 2844 1767 M16377 GO_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that modulates the extent to which blood vessels can be pervaded by fluid. 11/38 Gene Ontology BP GO:0043114 9.53833983823646e-09 6.64962640674653e-08 825 1648.45454545455 1913 8.67121807235544e-10 40 1.49701292647783 1.66407132618844 1 9.97355297731164 825 2984 1913 2977 2012 618 756 40 2842 2676 490 1768 M11201 GO_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DETERMINATION.html Any process that establishes and transmits the specification of sexual status of an individual organism. 5/29 Gene Ontology BP GO:0007530 6.14721028492764e-07 1.45397337508502e-06 4165 2371.72727272727 1916 6.14721198539704e-08 41 2.36091817007535 -2.620551776738 -1 12.7930107098984 4162 1641 3707 994 1916 4213 4150 1110 41 1496 2659 1769 M15928 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 13/27 Gene Ontology BP GO:0030949 9.3749791770129e-05 0.000138359912011669 960 2120.45454545455 1916 8.52307154719507e-06 355 1.81180798482027 2.05501345709787 1 6.49015277326913 959 3695 1916 4033 4092 698 355 1106 3392 2319 760 1770 M13318 GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. 10/31 Gene Ontology BP GO:1901623 2.47943844861684e-07 6.79978305784288e-07 4170 2423.36363636364 1917 2.25403520732176e-08 594 2.14778932512299 -1.66143659335639 -1 12.296183079383 4166 1917 786 1144 1625 4182 3523 2933 1334 594 4453 1771 M10972 GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. 10/28 Gene Ontology BP GO:0033032 0.000103337242294309 0.0001517377659622 1640 1992.09090909091 1920 9.3947360469174e-06 1065 1.44372576624514 1.67802014974927 1 5.11791226629686 1640 1920 2097 1576 3032 2283 1619 2516 1065 2467 1698 1772 M12120 GO_RESPONSE_TO_XENOBIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_XENOBIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. 42/205 Gene Ontology BP GO:0009410 4.91019253098294e-08 1.94025735500883e-07 3450 2328.18181818182 1920 4.46381149143072e-09 904 1.8460095887495 -1.42499681795616 -1 11.5017556307004 3545 1598 904 1433 1077 2268 3446 4475 1494 1920 3450 1773 M10872 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME.html A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. 11/33 Gene Ontology BP GO:0001977 9.40258723373753e-07 2.11001510518334e-06 1965 1926.27272727273 1921 8.54781022937709e-08 1441 1.71233432420475 2.1197802647682 1 9.02148915262069 1961 1816 1761 1921 2000 2758 2080 1484 1718 1441 2249 1774 M15470 GO_CELLULAR_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 144/401 Gene Ontology BP GO:1901653 3.2749883955338e-08 1.45019201656077e-07 1925 2205.54545454545 1921 2.97726222207846e-09 939 1.58403055548784 1.54234077664683 1 10.0553749650736 1921 1012 1023 1330 939 4027 2416 4629 2432 1095 3437 1775 M10210 GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 10/40 Gene Ontology BP GO:0045745 6.0841461477915e-07 1.44052476105028e-06 2435 1932.90909090909 1922 5.53104348215957e-08 578 1.46760892230416 1.85927531937086 1 7.95797030944413 2432 578 1922 1185 1887 3186 2087 1631 2541 1858 1955 1776 M12778 GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT.html The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. 241/630 Gene Ontology BP GO:0061458 1.54720109954061e-09 2.40256010206256e-08 1925 2013.36363636364 1923 1.40654645511701e-10 25 1.90171654285819 1.91503501438885 1 13.4502841979996 1923 1831 322 1529 25 3883 2353 4274 1951 462 3594 1777 M13378 GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION.html Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 12/24 Gene Ontology BP GO:0010935 8.37352643546794e-06 1.47545666944507e-05 1970 2019.81818181818 1923 7.61232573320168e-07 940 2.37529153367532 3.10033729386611 1 10.6519643242564 1970 2957 1326 1670 2545 2813 1656 1614 940 2804 1923 1778 M13771 GO_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 15/44 Gene Ontology BP GO:0033198 5.47957248554552e-06 1.00361558384173e-05 1335 1995.63636363636 1923 4.98144193967747e-07 719 1.97541127147528 2.007356914044 1 9.16559157209063 1333 3245 1923 3393 2456 1105 719 2312 2641 1560 1265 1779 M16278 GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 10/19 Gene Ontology BP GO:0060315 1.64197128587672e-07 4.86399411493216e-07 2500 1882.81818181818 1924 1.49270128038669e-08 662 1.50240496975798 -0.914254643283874 -1 8.80425092785609 1967 972 1822 1362 1493 3294 2496 1924 662 2500 2219 1780 M12301 GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 18/74 Gene Ontology BP GO:0070286 1.76464469844085e-06 3.65117884797722e-06 2355 1859.63636363636 1926 1.60422373989434e-07 585 1.62005945873821 -1.74201431743134 -1 8.17720147411403 2351 1906 2105 1926 2169 1354 3111 585 1448 2411 1090 1781 M12105 GO_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_OLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 258/614 Gene Ontology BP GO:0051259 1.50625056247825e-08 8.7574463447947e-08 2295 1825.90909090909 1928 1.36931870253721e-09 277 1.68309331052412 2.04281721463583 1 11.0264510542697 2292 277 571 1900 639 4285 2194 2034 1928 1040 2925 1782 M12488 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. 18/44 Gene Ontology BP GO:1904036 1.4699239556406e-07 4.43460489021398e-07 1890 2146.90909090909 1929 1.33629459441198e-08 1277 1.45561737828735 1.58386923998226 1 8.58430492693086 1887 1682 1753 2574 1461 2246 1277 2615 3452 1929 2740 1783 M11223 GO_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTATIC_PROCESS.html Any biological process involved in the maintenance of an internal steady state. 683/1868 Gene Ontology BP GO:0042592 7.21206298948171e-09 5.77597192485712e-08 1485 1751.72727272727 1930 7.21206301288794e-10 9 1.80110541520681 2.08411088692642 1 12.1017824484366 1482 9 3712 712 393 3860 1930 2634 2063 234 2240 1784 M13647 GO_BILE_ACID_AND_BILE_SALT_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_AND_BILE_SALT_TRANSPORT.html The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/63 Gene Ontology BP GO:0015721 1.34674618955449e-06 2.88286886035109e-06 1935 1866.72727272727 1934 1.22431546725072e-07 693 2.56501636540082 3.11855967918306 1 13.1911533138042 1934 1248 693 1092 2102 3002 2095 3186 967 1291 2924 1785 M12025 GO_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENTATION.html The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. 47/105 Gene Ontology BP GO:0043473 9.68780884883283e-08 3.19918182682296e-07 2845 1853.90909090909 1935 8.80709934130939e-09 654 1.60231317898379 -1.45826815491291 -1 9.66035509635084 2842 654 1977 1628 1322 1189 3695 2323 837 1991 1935 1786 M12045 GO_LIPID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. 58/179 Gene Ontology BP GO:0055088 4.39319713926769e-09 4.43426398209128e-08 1845 2005.54545454545 1935 3.99381558912772e-10 194 1.72072827126392 2.059291342819 1 11.7450950279028 1841 2308 1374 1140 194 3395 1935 2726 2479 1891 2778 1787 M11347 GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM.html The process in which an organism effects a change in the structure or processes of a second organism. 55/206 Gene Ontology BP GO:0035821 2.4911948189914e-07 6.82396315314281e-07 1640 2544.90909090909 1940 2.26472281916791e-08 1604 1.81875393838338 2.17034065677905 1 10.4098391236821 1637 4191 1933 3585 1627 3530 1821 1940 2973 3153 1604 1788 M12038 GO_SPECIFICATION_OF_SYMMETRY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_SYMMETRY.html The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 76/206 Gene Ontology BP GO:0009799 4.52689288912811e-08 1.84048718776023e-07 2710 2265.45454545455 1940 4.11535725661548e-09 1030 1.62410391123559 1.79803355275348 1 10.1537128946005 2708 1030 1485 1334 1039 4549 3125 2423 1848 1940 3439 1789 M12319 GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neutrophil migration. 13/50 Gene Ontology BP GO:1902624 5.76261446155176e-07 1.37774556874278e-06 1940 2122 1940 5.23874179181308e-08 1579 1.60838246459012 1.6638075905352 1 8.75019352871165 1940 2011 1671 2781 1869 1733 1579 2297 3522 1781 2158 1790 M12479 GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. 22/76 Gene Ontology BP GO:0032651 1.47659648388127e-06 3.1319495087532e-06 1010 1745.36363636364 1942 1.34236134085869e-07 326 1.6923231533839 1.84209673469224 1 8.64660202512282 1009 2593 2052 2834 2762 1032 655 326 3353 1942 641 1791 M14294 GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. 55/211 Gene Ontology BP GO:0050830 3.29568286316665e-06 6.32308079904245e-06 2350 1805.36363636364 1943 2.9960798183946e-07 497 1.83731835733853 -1.98388708783612 -1 8.86705326432652 2349 1943 794 1736 2344 1383 2612 1798 2317 497 2086 1792 M15085 GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. 59/158 Gene Ontology BP GO:0043467 7.56906200742751e-06 1.34751360814747e-05 1420 1917.90909090909 1943 6.88098913525461e-07 580 1.60951480658781 2.043002355232 1 7.27670380052784 1416 2257 1881 1934 2523 2752 1958 580 2126 1943 1727 1793 M15184 GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. 24/59 Gene Ontology BP GO:0030834 1.18556194478344e-06 2.58308968072712e-06 1950 2132.45454545455 1946 1.07778416697593e-07 1231 1.41857593929338 1.30293880556278 1 7.35812694812655 1946 1231 1629 1729 2057 2442 1595 4021 1611 2160 3036 1794 M16930 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 30/86 Gene Ontology BP GO:0045980 1.26908191744114e-06 2.73935255354682e-06 1905 2177.81818181818 1947 1.15371149956228e-07 1540 1.57045663195459 1.927508916976 1 8.10874332451429 1902 2550 1683 2981 2083 2754 1815 1540 2843 1947 1858 1795 M11211 GO_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. 100/263 Gene Ontology BP GO:0042593 6.92121341827131e-07 1.60675969505168e-06 1155 2123.09090909091 1948 6.29201417790021e-08 1154 1.62149790134424 1.86895780304326 1 8.72102822422461 1154 2906 1948 3235 1925 2370 1702 1649 2968 2096 1401 1796 M14445 GO_CARBOHYDRATE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. 100/263 Gene Ontology BP GO:0033500 6.92121341827131e-07 1.60675969505168e-06 1155 2122.09090909091 1949 6.29201417790021e-08 1155 1.62149790134424 1.86895780304326 1 8.72102822422461 1155 2907 1949 3236 1926 2371 1703 1628 2969 2097 1402 1797 M16170 GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. 30/62 Gene Ontology BP GO:0060603 1.42550206371944e-08 8.46369064175109e-08 2115 1585.45454545455 1949 1.2959109754146e-09 337 2.21179714796679 2.33758127147057 1 14.5205716813415 2114 1949 634 536 621 3165 1966 2295 337 764 3059 1798 M10461 GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. 5/23 Gene Ontology BP GO:0003148 8.62521796961265e-07 1.94970238719141e-06 1955 2186.81818181818 1951 8.62522131736178e-08 851 1.7167018002103 1.76832886768295 1 9.09918536917222 1951 1498 3589 1803 2003 2236 1688 4370 1251 851 2815 1799 M15202 GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. 26/58 Gene Ontology BP GO:1901862 1.80544296257725e-06 3.72067096105023e-06 2395 1963.45454545455 1951 1.64131313111487e-07 965 1.73914675815968 2.22503312335103 1 8.76507227083052 2395 1145 1466 1147 2178 3876 2540 1823 965 1951 2112 1800 M12125 GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. 5/10 Gene Ontology BP GO:0031284 2.17520734272479e-09 3.05120474086743e-08 4115 2243.81818181818 1952 2.17520734485397e-10 62 2.11433413483664 -1.76066321002203 -1 14.7503488710406 4112 737 3853 469 62 4197 2952 3365 1482 1501 1952 1801 M12775 GO_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 56/118 Gene Ontology BP GO:0038127 5.59039231468509e-08 2.13105020665705e-07 4450 2340 1952 5.0821749606744e-09 1120 1.69468300186484 -1.81738892918134 -1 10.4948201175522 4446 1358 1454 1177 1120 3719 3495 2528 1952 1764 2727 1802 M15598 GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 26/82 Gene Ontology BP GO:0050994 2.90924278581871e-07 7.74519165972263e-07 2270 2071.36363636364 1952 2.64476651866557e-08 922 1.48398438698708 1.68203335113716 1 8.41799107597231 2269 1459 1625 2648 1674 3272 2207 922 2990 1952 1767 1803 M10798 GO_ENDOCARDIAL_CUSHION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_DEVELOPMENT.html The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 17/53 Gene Ontology BP GO:0003197 4.75189977605371e-09 4.60880543882876e-08 2915 2243 1953 4.31990889665235e-10 216 1.53173070545297 1.59228697937042 1 10.4312233039323 2915 1685 1180 1212 216 4192 1953 4008 2285 1807 3220 1804 M12330 GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 31/78 Gene Ontology BP GO:0045661 3.69399716248618e-08 1.58221668131212e-07 3115 2267.54545454545 1953 3.35817929501065e-09 683 1.73403890267022 2.02799922592309 1 10.9467137511176 3114 1377 914 1953 979 4414 3130 3239 1432 683 3708 1805 M12649 GO_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASOCONSTRICTION.html A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. 14/39 Gene Ontology BP GO:0042310 3.07826216341228e-05 4.91146777481898e-05 1230 1737 1954 2.7984593051003e-06 757 3.43975963810362 3.46159865360577 1 13.7579088956997 1227 2241 757 1168 2814 2005 2170 2451 905 1415 1954 1806 M16873 GO_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_FUSION.html A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 11/49 Gene Ontology BP GO:0007520 1.83252642322166e-06 3.76312259310843e-06 2870 1898.90909090909 1954 1.66593449968788e-07 347 2.69336869768716 -1.54594220400586 -1 13.5619077325385 2867 971 823 347 2184 3917 3060 1954 499 1457 2809 1807 M16484 GO_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 61/170 Gene Ontology BP GO:0046165 1.36720924911375e-07 4.18454353568565e-07 3875 2240.45454545455 1956 1.24291757643652e-08 1251 1.83941086463738 -1.90017913240786 -1 10.89071412318 3875 1773 1488 1946 1439 1956 3825 1251 2031 2098 2963 1808 M10438 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 7/40 Gene Ontology BP GO:0046189 1.11066395013933e-06 2.43705705127453e-06 1520 1985.63636363636 1957 1.11066450524821e-07 1019 2.02698297231098 -2.02698297231098 -1 10.5614772496361 1516 2375 3584 2638 2065 1613 2259 1685 1019 1957 1131 1809 M11165 GO_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of exocytosis. 90/250 Gene Ontology BP GO:0017157 8.92312767772371e-08 2.99134164676326e-07 4500 2442.36363636364 1957 8.11193458149348e-09 879 1.39956442043066 -1.28762955510037 -1 8.47588189457518 4500 1354 1957 1871 1299 1790 4519 3233 2767 879 2697 1810 M14762 GO_RHYTHMIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_PROCESS.html Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. 152/434 Gene Ontology BP GO:0048511 5.44299012356889e-09 4.97122471997677e-08 1595 1669.81818181818 1957 4.94817285185028e-10 258 1.84458763317181 2.03779938528074 1 12.5055166288606 1595 2413 501 2080 258 3190 1957 2088 2216 850 1220 1811 M16219 GO_SINGLE_ORGANISM_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CATABOLIC_PROCESS.html A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism. 493/1233 Gene Ontology BP GO:0044712 3.22545391661055e-09 3.84357595519315e-08 4230 2167.90909090909 1958 2.93223083758131e-10 112 1.67294985071022 -1.29496158230061 -1 11.5153914479932 4229 605 307 2584 112 1095 4439 4240 1958 988 3290 1812 M10955 GO_GLUTAMATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. 14/33 Gene Ontology BP GO:0006536 2.10386429147244e-08 1.06407863892228e-07 3765 2073.18181818182 1959 1.91260391962886e-09 545 1.46581225138646 -1.23442416871589 -1 9.48787123098914 3762 694 1546 1157 775 1959 2927 3975 545 2438 3027 1813 M12603 GO_RESPONSE_TO_PROSTAGLANDIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 26/107 Gene Ontology BP GO:0034694 3.10965200524628e-05 4.95474065214772e-05 1135 2037.54545454545 1960 2.82699632760799e-06 1132 1.97055498972925 1.91188544541905 1 7.87460420320183 1132 2357 1229 2097 2818 1923 1547 2524 2877 1949 1960 1814 M15182 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. 479/1288 Gene Ontology BP GO:0045944 3.01485832669707e-09 3.71516474551579e-08 1710 1813.09090909091 1960 2.74078030075327e-10 100 1.50527186291993 1.67593791253059 1 10.3818362034376 1706 995 1343 2394 100 3510 1960 2063 2534 841 2498 1815 M16967 GO_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 12/40 Gene Ontology BP GO:0071731 0.000259243493271629 0.000363426189390149 1005 2212 1960 2.35703679122256e-05 486 2.32994359249115 2.32994359249115 1 7.43910056173951 1003 3871 1197 3217 3840 1046 486 1960 3807 2189 1716 1816 M12261 GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. 16/46 Gene Ontology BP GO:0030513 6.45208655050538e-08 2.33310263660409e-07 1965 1943.81818181818 1962 5.86553339975459e-09 1183 1.48416830270645 1.63271386838984 1 9.13694760305855 1963 1472 1962 1572 1183 3337 2241 2039 1616 2195 1802 1817 M16292 GO_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 168/463 Gene Ontology BP GO:0009416 2.85266914519618e-08 1.32582010421881e-07 2385 2121 1962 2.59333562016893e-09 884 1.53518486791424 1.84649745509743 1 9.8007968145342 2381 1205 1593 1962 884 4555 2376 2404 1905 1470 2596 1818 M16809 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. 10/36 Gene Ontology BP GO:0010575 7.37555836267875e-07 1.70117821549515e-06 1965 2084 1962 6.70505530486856e-08 1620 1.80822570973767 2.35340131343256 1 9.68369596852978 1962 2444 1708 2007 1943 2943 2321 2178 1620 1884 1914 1819 M12334 GO_FATTY_ACID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. 12/37 Gene Ontology BP GO:0055089 3.6998217143504e-07 9.47505362367838e-07 4350 2548.72727272727 1963 3.36347485142119e-08 876 1.56556276886599 -1.2874094916743 -1 8.75351827099534 4350 1620 1900 1005 1740 3918 3793 1963 876 2798 4073 1820 M11349 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. 16/41 Gene Ontology BP GO:0030835 7.94707385802894e-07 1.81496625296746e-06 3010 2099.72727272727 1964 7.22461520796081e-08 407 1.52291778966025 -1.57412237965367 -1 8.11601949419576 3010 407 1340 1395 1964 3147 2497 3106 464 1678 4089 1821 M12359 GO_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 276/935 Gene Ontology BP GO:0034220 3.69831898683397e-08 1.5826078392507e-07 1965 1935.27272727273 1965 3.36210822636793e-09 137 1.62832154564113 1.84634315894096 1 10.2791744932927 1965 895 377 1192 980 4467 2620 4120 2119 137 2416 1822 M16427 GO_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATED_EXOCYTOSIS.html A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. 122/351 Gene Ontology BP GO:0045055 4.28214717755554e-07 1.0677770862186e-06 1030 1959.90909090909 1965 3.89286182822361e-08 927 1.6091511222953 1.80638259579356 1 8.91971159931652 1029 2208 936 3446 1788 1965 1247 2445 2889 927 2679 1823 M12217 GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. 227/567 Gene Ontology BP GO:0044283 1.32169117876733e-08 8.1342747262004e-08 4615 2313.72727272727 1966 1.20153744246148e-09 588 1.63293751931096 -1.37295559492992 -1 10.7464595010644 4611 759 1088 2384 588 1575 4566 2873 1966 1358 3683 1824 M12933 GO_ONE_CARBON_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_COMPOUND_TRANSPORT.html The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/11 Gene Ontology BP GO:0019755 7.29116932469489e-07 1.68422383953027e-06 2375 1992.72727272727 1967 7.29117171694774e-08 723 3.04722339179226 -2.79582136148517 -1 16.3312766917284 2371 723 3982 1353 1967 2416 2623 1729 1637 968 2151 1825 M13267 GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. 7/21 Gene Ontology BP GO:0033605 2.10853588108998e-07 5.90110433749292e-07 3500 2453.81818181818 1967 2.10853608115656e-08 217 1.78531205985808 -0.951304158763111 -1 10.3230077660757 3500 588 4041 1057 1609 3861 3855 1710 217 1967 4587 1826 M16525 GO_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GTPASE_ACTIVITY.html Any process that modulates the rate of GTP hydrolysis by a GTPase. 306/772 Gene Ontology BP GO:0043087 1.99907520174547e-09 2.85590958821668e-08 1970 1925.45454545455 1968 1.81734109414725e-10 47 1.57329769758299 1.8119754621233 1 11.0178392588592 1968 750 940 1393 47 4258 2484 2453 2077 888 3922 1827 M10946 GO_PEPTIDYL_SERINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_SERINE_MODIFICATION.html The modification of peptidyl-serine. 92/216 Gene Ontology BP GO:0018209 9.43983558890062e-08 3.12841946033302e-07 1790 2016.27272727273 1969 8.58166908540756e-09 1295 1.35916556581349 1.43835244979541 1 8.20667242183177 1787 1512 2621 1295 1316 2606 1969 2299 2766 1893 2115 1828 M10392 GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 8/18 Gene Ontology BP GO:0009151 1.88578450043038e-06 3.85204462626408e-06 1525 2041.27272727273 1970 1.88578610071472e-07 779 0.90609028996256 -0.988624262864193 -1 4.55390128387567 1522 1970 3577 2851 2228 779 1197 1127 3245 2902 1056 1829 M13943 GO_LIPID_PARTICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. 6/19 Gene Ontology BP GO:0034389 4.92286261949285e-07 1.19983470563282e-06 1520 1924.18181818182 1973 4.92286371004911e-08 111 1.03121144074322 -1.03121144074322 -1 5.66764975650982 1519 2869 4161 2511 2989 385 663 544 1973 3441 111 1830 M11344 GO_THYROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. 3/17 Gene Ontology BP GO:0042403 9.95258199480299e-08 3.26340665267445e-07 2315 1790.18181818182 1975 9.9525824405455e-09 113 4.44140755873237 -4.44140755873237 -1 26.7416823941849 2311 1975 3733 1316 2977 1479 2140 113 138 2848 662 1831 M13301 GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 13/33 Gene Ontology BP GO:0010644 3.50783465021678e-05 5.52847124268721e-05 1975 2033.45454545455 1975 3.18899143895169e-06 973 1.99727303247472 1.52198787258873 1 7.89315278430721 1975 2366 1548 1423 2845 2414 1674 2595 973 1290 3265 1832 M15497 GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. 25/80 Gene Ontology BP GO:0042149 1.44721690024237e-08 8.57069906610372e-08 1835 2070 1975 1.31565173614776e-09 130 1.88052346771755 2.37293510671504 1 12.336216581341 1835 3114 1673 2421 627 3439 2914 130 1975 3152 1490 1833 M13682 GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 3/19 Gene Ontology BP GO:0010919 7.50328313555806e-05 0.000112198852168747 3335 2610.27272727273 1976 7.5035364942581e-06 151 2.65410590867236 -1.72211528455808 -1 9.73163365085947 3333 1976 4116 1449 3001 4500 4580 1892 151 1758 1957 1834 M15689 GO_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTOSIS.html A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells. 174/474 Gene Ontology BP GO:0006887 4.68202406010251e-08 1.88050499230588e-07 1620 1991.18181818182 1976 4.25638559976819e-09 869 1.57098004858149 1.89766136106366 1 9.8079657738697 1619 1112 869 2498 1053 3247 1976 2539 2552 921 3517 1835 M13722 GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 59/172 Gene Ontology BP GO:0010906 1.26160707472572e-07 3.92127091648298e-07 1410 1999.72727272727 1978 1.14691558824869e-08 1202 1.58446732416396 1.91595320814785 1 9.42276173358918 1409 2545 1744 2993 1411 2341 1978 1202 2386 2510 1478 1836 M15826 GO_STEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 60/191 Gene Ontology BP GO:0016125 1.02755763274288e-08 6.94461439421423e-08 3360 2247.72727272727 1978 9.3414330685664e-10 116 1.73296350326855 1.75317114791103 1 11.5152028550481 3359 116 984 1096 499 3651 3772 4459 1978 878 3933 1837 M12081 GO_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSPORT.html The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 198/632 Gene Ontology BP GO:0006820 4.77722407896637e-08 1.90391857499063e-07 1415 1749 1979 4.34293107518376e-09 385 1.7632967769326 2.06819522854433 1 10.9998444836748 1415 1274 385 1979 1064 3700 2039 2512 2253 419 2199 1838 M15417 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. 77/211 Gene Ontology BP GO:1990267 8.31391607196446e-07 1.88408287630992e-06 1760 2043.27272727273 1979 7.55810837621715e-08 755 1.89507222087372 2.28492818721465 1 10.0707729285472 1756 2211 755 1512 1979 4042 2820 2446 2275 824 1856 1839 M13066 GO_MIDDLE_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDDLE_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). 9/30 Gene Ontology BP GO:0042474 7.58166789111179e-07 1.74093392771672e-06 1130 2028.45454545455 1981 7.58167047778898e-08 782 1.47510837850835 1.68950579002205 1 7.8859960811247 1127 2157 4006 2550 1981 1280 782 2542 3219 1654 1015 1840 M16775 GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 13/17 Gene Ontology BP GO:0010839 3.77461514997459e-07 9.62178617469147e-07 1055 1860.81818181818 1984 3.4314689069076e-08 703 1.46380638728666 1.64158726756544 1 8.17550002856065 1053 703 1984 2467 1746 2331 2037 2699 2221 1792 1436 1841 M16897 GO_FATTY_ACID_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_ELONGATION.html The elongation of a fatty acid chain by the sequential addition of two-carbon units. 7/13 Gene Ontology BP GO:0030497 9.08836544825553e-07 2.04642486790739e-06 3395 2237.90909090909 1985 9.08836916518506e-08 26 1.54189059355194 -0.734417157480784 -1 8.14252207049577 3393 237 4634 1258 2021 4374 3890 858 26 1985 1941 1842 M12544 GO_IN_UTERO_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IN_UTERO_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. 168/428 Gene Ontology BP GO:0001701 7.98001920331997e-09 6.05412241193049e-08 2420 2234.45454545455 1986 7.2545629384234e-10 396 1.70373037822979 1.74767386330336 1 11.4152071990193 2416 1655 1222 1456 396 4342 2470 2955 1940 1986 3741 1843 M16329 GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 191/682 Gene Ontology BP GO:0098660 3.0558135637387e-08 1.38963196635052e-07 1990 1846.54545454545 1986 2.77801236925831e-09 55 1.59567371712264 1.74846410614168 1 10.1567256398703 1986 55 523 900 909 4461 2530 4102 2087 255 2504 1844 M16832 GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 12/26 Gene Ontology BP GO:0043518 6.252135319631e-08 2.30162001994041e-07 2065 2081.90909090909 1986 5.68375954300832e-09 860 0.888418527094372 1.06496590596644 1 5.47421412428864 2062 860 2601 1823 1165 2771 1661 1785 2278 3909 1986 1845 M13727 GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 48/103 Gene Ontology BP GO:0042451 6.89620649710028e-07 1.60416266362909e-06 1355 2146.90909090909 1987 6.26928059892112e-08 859 0.964919886472836 -0.886674256254025 -1 5.19033280792847 1355 1366 3230 2280 1920 859 1804 2654 2373 3788 1987 1846 M16242 GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 48/103 Gene Ontology BP GO:0046129 6.89620649710028e-07 1.60416266362909e-06 1360 2145.63636363636 1988 6.26928059892112e-08 860 0.964919886472836 -0.886674256254025 -1 5.19033280792847 1356 1367 3231 2281 1921 860 1805 2630 2374 3789 1988 1847 M16837 GO_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 76/200 Gene Ontology BP GO:0051592 7.56672987182014e-09 5.8723265524949e-08 2320 2114.09090909091 1989 6.87884536167759e-10 372 1.61877363339799 1.69987685713537 1 10.8658828146463 2317 916 875 1321 372 3745 1989 4593 2497 1094 3536 1848 M14356 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING.html Any cell surface receptor signaling pathway that is involved in cell-cell signaling. 24/99 Gene Ontology BP GO:1905114 2.21869934024217e-06 4.43461457471806e-06 1945 2108.45454545455 1990 2.01700143436632e-07 1274 1.79393394469828 1.96076195530289 1 8.91424396708907 1945 2180 1990 1860 2245 3191 1695 2881 1274 1386 2546 1849 M16788 GO_LEUKOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. 38/87 Gene Ontology BP GO:0001776 1.34168514538731e-07 4.12669224364604e-07 1990 1964 1990 1.21971384291901e-08 804 1.34149135188494 1.76310731103833 1 7.95017989157133 1990 804 2264 1618 1430 2859 1768 1383 2458 3008 2022 1850 M13598 GO_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INTERNALIZATION.html A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. 23/81 Gene Ontology BP GO:0031623 4.44169108604405e-09 4.46380340097457e-08 1995 1985 1992 4.03790099546508e-10 198 1.55059347650466 1.46942983508584 1 10.5796634491457 1992 1462 1583 2161 198 2364 1358 3907 2571 1280 2959 1851 M11810 GO_REGULATION_OF_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_FORMATION.html Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. 11/52 Gene Ontology BP GO:0003156 8.89045200100804e-07 2.00380430294565e-06 1730 1969.54545454545 1993 8.08223235794868e-08 927 2.33689404082136 -1.30733114201745 -1 12.3606591127074 1726 2442 1582 1078 1993 2552 1527 2745 927 2654 2439 1852 M15314 GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. 5/16 Gene Ontology BP GO:0072505 7.48328848221219e-07 1.72260329315375e-06 3085 2127.45454545455 1994 7.48329100219566e-08 90 2.03608464562156 -0.835575023386078 -1 10.8936890677057 3084 1577 4384 1582 1994 3842 2851 281 90 2286 1431 1853 M13000 GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. 104/204 Gene Ontology BP GO:0007265 4.71463901874121e-08 1.88870310302118e-07 2165 2065.09090909091 1995 4.28603556343343e-09 1030 1.74359186802828 2.13414084285268 1 10.8825607651309 2165 1588 1030 1995 1057 4199 2289 1442 1479 2049 3423 1854 M15039 GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 31/65 Gene Ontology BP GO:0009066 4.72149940328289e-07 1.15927666469817e-06 3075 2252.36363636364 1996 4.29227310598293e-08 1822 1.41225618659654 -1.45959518053497 -1 7.78149101828531 3075 1899 1996 1939 1822 2119 3335 1926 1935 2407 2323 1855 M12514 GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM.html Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. 262/924 Gene Ontology BP GO:0098542 3.23741234999579e-08 1.44213369789309e-07 2660 2140 1997 2.94310217966905e-09 802 1.61424033521164 -1.54698258930841 -1 10.2507718633964 2657 2842 866 4522 933 802 3049 1822 2680 1370 1997 1856 M13437 GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. 12/44 Gene Ontology BP GO:0035116 9.31558511774674e-07 2.0935267038576e-06 1330 2341.09090909091 1998 8.46871732936388e-08 429 2.30448008721251 2.23318189481953 1 12.1485166856483 2927 1329 1351 1329 1998 4133 3059 4625 429 1176 3396 1857 M14022 GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that increases the extent to which blood vessels can be pervaded by fluid. 6/13 Gene Ontology BP GO:0043117 0.000224352745237784 0.000316616959312775 1755 2207.18181818182 2000 2.24375398826133e-05 1208 1.70320054077116 2.14041114733906 1 5.53269423277444 1755 2604 4172 2000 3168 1931 2193 1432 1273 2543 1208 1858 M15494 GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 39/90 Gene Ontology BP GO:0046889 7.93483476773727e-07 1.81306288516753e-06 2970 2355.27272727273 2000 7.21348875420887e-08 999 2.2202546230662 2.68168371847781 1 11.8332455805485 2993 2220 999 1605 1963 4435 2970 1948 1807 2000 2968 1859 M12061 GO_GLYCEROLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. 167/425 Gene Ontology BP GO:0046486 2.91888598918808e-09 3.65029676110884e-08 3440 2312.09090909091 2002 2.65353272096433e-10 97 1.73500375994563 -1.46692357340062 -1 11.9786139113713 3439 479 971 1865 97 3447 3469 4390 2002 938 4336 1860 M14878 GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. 98/266 Gene Ontology BP GO:0050866 4.98350263769116e-07 1.21016750767783e-06 1640 1853.45454545455 2003 4.53045796960792e-08 496 1.87562760474951 2.07951167912302 1 10.3021687529631 1638 1658 496 2391 1838 3181 2003 2302 2060 597 2224 1861 M10807 GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 11/27 Gene Ontology BP GO:0009065 1.06220050654163e-07 3.4224822705571e-07 3945 2079.45454545455 2004 9.65636870751483e-09 220 1.45951093220399 -1.93061695724345 -1 8.75970068318931 3945 220 1267 710 1358 2951 4327 2749 979 2004 2364 1862 M11525 GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. 16/41 Gene Ontology BP GO:1900026 9.49238613574819e-07 2.12605638341914e-06 3775 2499.09090909091 2004 8.62944566495492e-08 768 1.56196006095354 -1.19451156755971 -1 8.22446838961061 3774 1551 1558 1509 2004 4622 3380 2006 768 1679 4639 1863 M12126 GO_MELANIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. 5/18 Gene Ontology BP GO:0006582 1.19058413963657e-06 2.59159970010906e-06 2605 1844.72727272727 2004 1.19058477750782e-07 271 2.01626766890487 -2.21062350778279 -1 10.4556694033948 2601 880 3854 1635 2093 2291 2792 369 271 1502 2004 1864 M14458 GO_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DIFFERENTIATION.html The establishment of the sex of an organism by physical differentiation. 164/438 Gene Ontology BP GO:0007548 1.68944324109699e-09 2.54678083390043e-08 1880 2032.63636363636 2004 1.53585749308578e-10 33 1.9704086938318 2.01732848210331 1 13.889817056052 1880 2081 473 2004 33 3705 2075 4167 1923 560 3458 1865 M12064 GO_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION.html The controlled release of a substance by a cell or a tissue. 309/906 Gene Ontology BP GO:0046903 5.81529316110339e-12 1.34330378840811e-10 2115 1759.63636363636 2006 5.28663014647159e-13 187 1.84474392993253 2.20288415123895 1 16.9045147372153 2113 270 187 867 410 4153 2547 2851 2006 193 3759 1866 M15386 GO_CEREBELLAR_CORTEX_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_FORMATION.html The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 17/45 Gene Ontology BP GO:0021697 7.84991300284622e-06 1.39483911489533e-05 2735 1932.54545454545 2006 7.1363100114478e-07 343 2.06367458134099 -1.77821772341793 -1 9.30126780565974 2734 2006 1360 693 2529 2235 3624 3255 343 996 1483 1867 M11364 GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. 10/25 Gene Ontology BP GO:0050774 2.65148909500457e-05 4.2746055097591e-05 4135 2315.54545454545 2007 2.41047368352915e-06 247 1.82053723897477 1.72876452865188 1 7.38347953637754 4132 1567 2007 1245 2781 4289 2491 1838 247 1864 3010 1868 M15853 GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION.html A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. 195/501 Gene Ontology BP GO:0023014 5.53786152613964e-09 4.99267787686725e-08 4215 2199.27272727273 2009 5.03441958189055e-10 263 1.45553695883626 -1.28729846859131 -1 9.86539232460105 4211 289 2009 1183 263 1794 3316 4611 2513 1541 2462 1869 M12188 GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 9/21 Gene Ontology BP GO:0010893 2.21157501853885e-05 3.61052841458364e-05 2285 2127.18181818182 2010 2.21159702863541e-06 705 2.19348345164325 -2.88772435272554 -1 9.04532161123207 2285 1758 3866 2010 3651 1561 2595 705 1106 3075 787 1870 M14747 GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein depolymerization. 14/30 Gene Ontology BP GO:1901881 1.57942842867853e-06 3.32123468947211e-06 2815 2362.09090909091 2010 1.43584505689646e-07 1336 1.80269403933479 -1.8395954262342 -1 9.16787556410372 2812 2010 1336 1839 2134 3039 1937 3765 1508 1907 3696 1871 M11115 GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 106/228 Gene Ontology BP GO:0044272 3.98268774726596e-08 1.66891870131371e-07 4110 2272 2011 3.62062529033189e-09 1003 1.51982372136924 -1.23001257250174 -1 9.56172020928281 4108 1019 1290 2260 1003 1386 4137 4068 2158 1552 2011 1872 M10255 GO_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 30/64 Gene Ontology BP GO:0010883 2.81959570552008e-06 5.49596257797219e-06 1225 2135.63636363636 2012 2.5632721083795e-07 1223 1.68491952264478 1.91759238291193 1 8.22679024340729 1223 2549 1481 2832 2308 1916 1327 2012 3144 1944 2756 1873 M11150 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. 60/110 Gene Ontology BP GO:0048010 4.10625337844557e-07 1.03167394134864e-06 2215 2184.63636363636 2013 3.73295831351751e-08 960 1.99692686783318 2.29358685818053 1 11.0968879553988 2213 2768 1508 960 1776 3743 2355 2013 1429 1744 3522 1874 M12168 GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. 11/24 Gene Ontology BP GO:0051446 9.63328400687062e-07 2.15211004891449e-06 4070 2527.81818181818 2014 8.75753475005668e-08 713 1.8978201753267 -1.89909875832213 -1 9.98361422429482 4066 2665 1626 1712 2007 3662 4636 1679 713 2014 3026 1875 M11558 GO_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE.html A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. 23/66 Gene Ontology BP GO:0090398 9.9035070094602e-07 2.20220225310937e-06 2735 1970.36363636364 2015 9.00319224329078e-08 413 1.54926230740498 2.21591616049281 1 8.13563072074146 2735 1800 1706 1150 2015 4353 2290 572 413 2459 2181 1876 M12910 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. 42/120 Gene Ontology BP GO:0002708 7.96431120167397e-07 1.81800869760926e-06 2210 2133.36363636364 2018 7.24028553169885e-08 1372 1.42134658124324 -1.20073549986416 -1 7.5737607418841 2210 1372 2018 2052 1965 1578 3318 2395 3079 1607 1873 1877 M13514 GO_REGULATION_OF_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of ion homeostasis. 113/303 Gene Ontology BP GO:2000021 1.23115771516234e-06 2.67115199602745e-06 1465 1614.27272727273 2018 1.1192349128544e-07 491 1.78734516968452 2.02518794695005 1 9.24677081413648 1464 491 548 923 2068 2967 2018 2596 2033 540 2109 1878 M15869 GO_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of sprouting angiogenesis. 23/46 Gene Ontology BP GO:1903670 4.06711863827084e-06 7.62666875504503e-06 860 1735 2019 3.69738741557548e-07 667 1.61411074944024 1.79056981565383 1 7.66786263326836 860 3208 2019 2096 2391 1150 1235 667 2053 2463 943 1879 M16946 GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 14/50 Gene Ontology BP GO:0010907 0.000194649320496864 0.000277311075503818 2270 2380.18181818182 2019 1.76969586010282e-05 1470 1.99091289962113 2.01805419892097 1 6.57369056665136 2268 3668 1906 2019 3131 3077 1949 1973 1470 1915 2806 1880 M14207 GO_GOLGI_TO_VACUOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_VACUOLE_TRANSPORT.html The directed movement of substances from the Golgi to the vacuole. 21/38 Gene Ontology BP GO:0006896 3.13265031189861e-08 1.40666299788639e-07 2025 2340.09090909091 2021 2.84786396045947e-09 846 0.973013167324989 -1.01534916575293 -1 6.18861054275957 2021 2623 3087 3869 921 846 1776 1675 3461 4091 1371 1881 M11758 GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. 67/154 Gene Ontology BP GO:1903650 5.40640309312881e-07 1.29927171642842e-06 2025 2164.72727272727 2022 4.91491311066273e-08 1271 1.36722274805876 -1.01771808504303 -1 7.47051943045361 2022 2213 2163 1783 1856 3993 1597 1583 2626 2705 1271 1882 M11056 GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION.html The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. 4/18 Gene Ontology BP GO:0048505 9.27290961156994e-06 1.61346111466022e-05 2025 1776.18181818182 2024 9.27294830588088e-07 64 2.48571312996971 3.29457178250856 1 11.0575480703365 2024 1499 3678 772 2595 2648 2555 795 64 2071 837 1883 M10503 GO_MYELOID_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MIGRATION.html The movement of a myeloid leukocyte within or between different tissues and organs of the body. 47/150 Gene Ontology BP GO:0097529 1.00654229582451e-06 2.22753855076893e-06 2520 2295.81818181818 2025 9.1503886939751e-08 635 2.38857966559772 2.46236128622302 1 12.5321172122567 2520 1894 635 1633 2025 4188 2951 3479 1962 950 3017 1884 M14964 GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC.html Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. 4/18 Gene Ontology BP GO:0040034 9.27290961156994e-06 1.61346111466022e-05 2025 1835.09090909091 2025 9.27294830588088e-07 65 2.48571312996971 3.29457178250856 1 11.0575480703365 2025 1500 4325 773 2596 2649 2556 768 65 2091 838 1885 M16118 GO_IMMUNOLOGICAL_SYNAPSE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE_FORMATION.html The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 21/51 Gene Ontology BP GO:0001771 5.60766762154227e-08 2.13556001798919e-07 1575 1972.18181818182 2025 5.09787978588941e-09 1121 1.65905617935142 2.12311236397662 1 10.2727766908002 1574 2979 1854 2025 1121 1888 1133 2159 2247 2240 2474 1886 M10285 GO_AMMONIUM_ION_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_METABOLIC_PROCESS.html The chemical reactions and pathways involving the ammonium ion. 66/208 Gene Ontology BP GO:0097164 2.18669593742592e-08 1.09641784421907e-07 4235 2489.72727272727 2026 1.98790541741877e-09 791 1.74331521149462 -1.51166910090408 -1 11.2630441184462 4234 1445 1185 2026 791 3463 3349 3756 1457 1593 4088 1887 M11228 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. 52/151 Gene Ontology BP GO:0051153 5.10823567461732e-08 1.99642577754615e-07 2310 2047.72727272727 2027 4.64385072111523e-09 838 1.97873318232656 2.25666920756411 1 12.3059391635671 2307 1134 908 1675 1089 4024 2078 3897 2027 838 2548 1888 M13310 GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. 10/35 Gene Ontology BP GO:0002579 0.000523115844765991 0.000709768225379455 1415 2071.90909090909 2028 4.75672975125135e-05 1335 2.49957758774664 2.83508621927026 1 7.30621314841627 1411 3041 1475 1757 3262 2149 1565 2116 2028 1335 2652 1889 M11005 GO_APICAL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_ASSEMBLY.html The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. 35/65 Gene Ontology BP GO:0043297 5.19622520731447e-06 9.55866625893863e-06 2890 1986.18181818182 2029 4.72385225493286e-07 1112 1.87518835611948 -1.71696486719427 -1 8.73742325388078 2889 2510 1112 2152 2445 1402 3087 1382 1390 2029 1450 1890 M16470 GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 20/42 Gene Ontology BP GO:0090314 8.62636444885371e-08 2.9192572985443e-07 3780 2623.09090909091 2030 7.84214980645448e-09 1286 1.39112368809495 -1.06876983350003 -1 8.43844391065067 3776 1397 2021 1814 1286 4272 3047 3422 2030 1357 4432 1891 M14205 GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a myeloid leukocyte. 24/91 Gene Ontology BP GO:0002444 0.000494960311406358 0.000673929831630416 1825 2437.54545454545 2031 4.50065185122295e-05 1211 2.02083564338986 2.55354509977552 1 5.94907072652299 1822 3427 1995 2687 3607 3054 1486 1211 1664 3829 2031 1892 M10878 GO_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. 3/16 Gene Ontology BP GO:0006182 0.00423803224240127 0.00524305454342369 1645 2323.18181818182 2032 0.000424613641595769 1425 2.99238259637171 2.99238259637171 1 6.33432374766435 1645 3027 3650 2032 3622 1536 1802 2390 1425 2846 1580 1893 M11817 GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 9/33 Gene Ontology BP GO:0061217 9.63652119684089e-07 2.15211004891449e-06 2105 2020.45454545455 2032 9.63652537565778e-08 583 1.66463067871295 -1.12178750475601 -1 8.75690473244814 2101 719 3811 583 2032 2635 2351 3655 1182 1648 1508 1894 M13793 GO_REGULATION_OF_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION.html Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. 13/63 Gene Ontology BP GO:0051931 0.00350573761973369 0.0043732240108607 1535 2141.81818181818 2033 0.000319212415217549 638 2.05314956765264 2.05314956765264 1 4.49628832588569 638 2859 1531 2330 3514 1638 1531 1896 3280 2310 2033 1895 M16683 GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 9/30 Gene Ontology BP GO:0061213 9.63652119684089e-07 2.15211004891449e-06 2105 2096.81818181818 2033 9.63652537565778e-08 584 1.66463067871295 -1.12178750475601 -1 8.75690473244814 2102 720 4604 584 2033 2636 2352 3673 1183 1669 1509 1896 M13384 GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 42/93 Gene Ontology BP GO:0046823 3.77576877240747e-07 9.62178617469147e-07 2035 2183.36363636364 2034 3.43251765493379e-08 802 1.33113298765578 1.86060186145577 1 7.43450626125567 2034 3001 2482 1931 1747 3423 1518 802 2185 2979 1915 1897 M13929 GO_PURINE_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOTIDE_TRANSPORT.html The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. 9/18 Gene Ontology BP GO:0015865 8.74481622617006e-06 1.53100232798294e-05 1980 2344.09090909091 2034 8.74485063867552e-07 1126 1.46126878472425 1.4263638305015 1 6.53127101807725 1976 1923 4159 2034 2587 2467 1945 3388 1126 1658 2522 1898 M14374 GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY.html Any process that activates or increases the activity of a cyclase. 22/72 Gene Ontology BP GO:0031281 7.86804904234423e-07 1.79868792238327e-06 3345 2521.27272727273 2034 7.15277441478513e-08 1069 1.82552865414303 -1.83514051924489 -1 9.73534082263454 3344 1463 1212 1069 1962 4317 2864 3889 2034 1202 4378 1899 M15527 GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of JUN kinase activity. 41/121 Gene Ontology BP GO:0043507 1.95635486781612e-07 5.54539417049464e-07 1510 2141 2034 1.77850458344129e-08 1506 1.54247475586118 1.81211831646104 1 8.95753737293889 1506 2973 2034 2538 1566 1913 1545 2321 3003 1841 2311 1900 M16918 GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN.html Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. 13/63 Gene Ontology BP GO:0051930 0.00350573761973369 0.0043732240108607 1535 2143.45454545455 2034 0.000319212415217549 639 2.05314956765264 2.05314956765264 1 4.49628832588569 639 2860 1532 2331 3515 1639 1532 1891 3281 2324 2034 1901 M11797 GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 20/46 Gene Ontology BP GO:0043516 6.74885185852974e-09 5.51671112309042e-08 1490 2014.72727272727 2035 6.13531989021174e-10 335 1.05538790832454 1.22834353808089 1 7.11078160951492 1486 1467 2577 2477 335 2243 1537 1533 2872 3600 2035 1902 M12562 GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 6/20 Gene Ontology BP GO:0045076 9.71581789078741e-07 2.16773390038087e-06 3860 2262.36363636364 2035 9.7158221386603e-08 432 2.7825725078092 -2.83394671352054 -1 14.6298008100443 3857 878 3932 1237 2035 2598 3779 1654 432 1079 3405 1903 M13610 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. 118/249 Gene Ontology BP GO:0048872 1.51018000193047e-08 8.7574463447947e-08 1755 2024.27272727273 2035 1.37289092027003e-09 641 1.50043172578312 1.94925406944092 1 9.8297799913591 1753 2035 2426 1388 641 3740 2147 1070 1813 3132 2122 1904 M10663 GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. 15/30 Gene Ontology BP GO:0006656 2.2476953665196e-06 4.48669371743358e-06 4490 2672.27272727273 2036 2.04336151177058e-07 918 1.9801923810344 -2.20026217263632 -1 9.83046116574157 4486 1858 1773 1943 2249 3649 4420 1430 918 2036 4633 1905 M10787 GO_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_PROLIFERATION.html The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. 6/25 Gene Ontology BP GO:0043616 2.89477095098525e-06 5.63067512585861e-06 1315 2235.54545454545 2036 2.89477472185665e-07 367 2.94513748093059 2.94513748093059 1 14.3511811389773 1314 3462 3634 2986 4098 1759 1112 410 367 3413 2036 1906 M13625 GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. 61/159 Gene Ontology BP GO:0046887 2.23701030045441e-06 4.46728551613327e-06 1600 1942.18181818182 2038 2.03364779554625e-07 1209 1.88655923343777 2.26858883155154 1 9.36892607340219 1600 2038 1209 2238 2248 2795 2291 1648 2375 1569 1353 1907 M15906 GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 12/38 Gene Ontology BP GO:0046473 2.02057848616082e-06 4.08603915994977e-06 2040 2111.54545454545 2038 1.83689121995722e-07 954 1.55258647692568 -1.25889591003437 -1 7.76620289946175 2038 3277 2372 3254 2218 954 1612 1900 1766 2187 1649 1908 M10448 GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that stimulates, induces or increases the rate of macrophage activation. 7/16 Gene Ontology BP GO:0043032 4.88183536589041e-05 7.51288087631063e-05 2185 2035.54545454545 2040 4.8819426146308e-06 824 1.71541193064257 -1.8394279994169 -1 6.56714473871386 2185 2639 3587 2451 2943 1094 2040 824 1545 1958 1125 1909 M13535 GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 203/474 Gene Ontology BP GO:0051348 6.57241701701368e-09 5.47858747037603e-08 2150 2042.63636363636 2040 5.97492457877136e-10 322 1.60154369671077 1.98701134751762 1 10.7950382258908 2149 1714 2040 1153 322 4609 2234 763 1880 2889 2716 1910 M14497 GO_LIPID_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 42/112 Gene Ontology BP GO:0046834 9.17581075788478e-09 6.53424683264709e-08 1935 2108.81818181818 2041 8.34164617832314e-10 448 1.95054125647133 1.95703127658582 1 13.0088596827113 1932 2506 1432 2041 448 3209 2236 2552 1835 1608 3398 1911 M15437 GO_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. 63/149 Gene Ontology BP GO:0050673 1.22943196281085e-08 7.70344480881349e-08 3240 2400.27272727273 2041 1.11766542698302e-09 569 1.68759943109441 1.68418323118304 1 11.1432159538084 3240 1129 837 1120 569 4505 2933 4194 2041 1229 4606 1912 M10650 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. 15/55 Gene Ontology BP GO:0032731 1.28025700847079e-06 2.75803579271835e-06 1995 2109.72727272727 2042 1.16387068499796e-07 899 1.65326224236585 1.85839215881933 1 8.53176353112176 1995 2689 2042 3165 2086 2266 1162 899 3525 2035 1343 1913 M14271 GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION.html The modification of a protein by cis-trans isomerization of a proline residue. 15/41 Gene Ontology BP GO:0000413 1.6100135825655e-06 3.37485014169373e-06 2655 2143 2042 1.46364978255805e-07 868 1.82853335738461 2.16719318992306 1 9.28748039774293 2651 1078 1535 868 2140 4492 3554 1575 933 2042 2705 1914 M13050 GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 35/104 Gene Ontology BP GO:0010517 9.02344382694339e-09 6.49643692121378e-08 2120 2068.63636363636 2044 8.2031307854124e-10 441 2.30368834054165 2.016175495213 1 15.3695138464865 2116 2044 800 2323 441 2800 1758 4158 1624 1098 3593 1915 M10315 GO_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACTIVATION_CASCADE.html A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. 25/269 Gene Ontology BP GO:0072376 9.95065367036938e-07 2.20740014293001e-06 1510 2066.72727272727 2045 9.04605288279743e-08 870 1.98265598576327 2.23724254916851 1 10.409623744735 1510 3238 888 2772 2020 2667 2045 1446 2835 870 2443 1916 M16616 GO_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_BACTERIUM.html Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 113/539 Gene Ontology BP GO:0042742 4.68148904290162e-07 1.15006103842287e-06 2415 2155 2046 4.2559000355447e-08 527 1.94132729096265 -2.03037464273369 -1 10.7029039679263 2414 2843 527 3699 1820 1526 3175 1964 2816 875 2046 1917 M15637 GO_PEPTIDE_HORMONE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_PROCESSING.html The generation of a mature peptide hormone by posttranslational processing of a prohormone. 10/44 Gene Ontology BP GO:0016486 9.19145841282466e-06 1.60074798990041e-05 1690 2264.36363636364 2047 8.35590619488271e-07 1344 1.49951596705631 1.63041301371007 1 6.67529020760365 1687 1965 2290 3628 2576 2047 1426 1344 2813 3215 1917 1918 M13726 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. 27/48 Gene Ontology BP GO:0008625 7.02385370855024e-07 1.62977275206391e-06 2285 2232.09090909091 2048 6.38532359184497e-08 1395 1.5485827686799 1.8105794349965 1 8.31998499843656 2283 1458 2270 1960 1929 4053 2585 1688 1395 2884 2048 1919 M16615 GO_RESPONSE_TO_LEAD_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEAD_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. 13/30 Gene Ontology BP GO:0010288 2.04820675622055e-06 4.12932000396526e-06 1950 2086.27272727273 2048 1.86200787555437e-07 1477 1.44104541835681 1.7484301643995 1 7.20214146329987 1947 1477 2100 1802 2226 2668 1633 2048 1598 2974 2476 1920 M11271 GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 46/224 Gene Ontology BP GO:0038094 3.8326414059595e-07 9.73998579522167e-07 2495 2200.81818181818 2051 3.4842200669526e-08 640 2.27409720311018 2.95446599506859 1 12.6898590193046 2492 2218 1833 1462 1753 3681 1925 2051 640 2567 3587 1921 M11983 GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. 23/44 Gene Ontology BP GO:0006778 9.16285242951157e-07 2.06119785999139e-06 3905 2241 2051 8.3298693143458e-08 288 1.54408557392513 -0.677751294838053 -1 8.14963598456859 3905 1307 2051 946 1997 2769 4532 1867 288 2460 2529 1922 M15157 GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that activates or increases the frequency, rate, or extent of peptide secretion. 47/128 Gene Ontology BP GO:0002793 2.99049837414902e-06 5.80471737089209e-06 1615 2094.90909090909 2054 2.71863858108487e-07 1087 1.90796087416242 2.23761419629333 1 9.27377154214608 1611 2847 1658 2908 2320 2691 2054 1087 2224 1992 1652 1923 M16513 GO_POLYOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 14/43 Gene Ontology BP GO:0046173 1.15097096781663e-06 2.51598785478937e-06 1670 2323.36363636364 2055 1.04633779088088e-07 1666 1.72182968816196 -1.74056335455029 -1 8.94936865447279 2930 2149 1666 1910 2049 2055 3115 3118 2986 1913 1666 1924 M12659 GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. 13/31 Gene Ontology BP GO:0052312 5.22203407534893e-07 1.26018213159278e-06 1740 2159.81818181818 2057 4.74730483170766e-08 695 2.40041515270871 2.57229680190837 1 13.1454545946951 1740 3754 2057 1932 1850 2738 1801 2685 695 2302 2204 1925 M14255 GO_CELLULAR_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCOSE_HOMEOSTASIS.html A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. 49/105 Gene Ontology BP GO:0001678 1.06156178712027e-07 3.4224822705571e-07 1075 2315.36363636364 2058 9.65056216676007e-09 1074 1.53637855217266 1.6832488909977 1 9.22104519522354 1074 3261 2280 3907 1356 2058 1813 2005 3656 2426 1633 1926 M15100 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 13/49 Gene Ontology BP GO:0032228 1.91385676927561e-07 5.45155642929242e-07 4060 2644.36363636364 2058 1.73986994160791e-08 422 1.47440454175172 -1.27034480342732 -1 8.5723807317269 4058 422 1931 1696 1557 3980 4215 3428 2058 1298 4445 1927 M11144 GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. 10/23 Gene Ontology BP GO:0061099 6.95331797989232e-06 1.24409461967784e-05 2060 2206.72727272727 2060 6.32121814239999e-07 1369 1.10218981772553 -1.17540963324946 -1 5.01854138424297 2060 1964 2125 1697 2508 1464 2604 1369 3572 3189 1722 1928 M12342 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that increases the frequency, rate or extent of cardiac muscle contraction. 6/16 Gene Ontology BP GO:0060452 4.21055784442348e-06 7.87338706067589e-06 2065 2106.81818181818 2061 4.21056582240357e-07 471 2.44919946167786 -1.31259556379598 -1 11.6035320151454 2061 3564 3892 1281 3329 2237 1666 471 1364 2532 778 1929 M10171 GO_OLIGOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 33/71 Gene Ontology BP GO:0009311 2.33546004983846e-07 6.45064902522306e-07 2040 2243 2062 2.12314572524051e-08 940 1.38801623333138 1.50407536236527 1 7.9759449802838 2039 940 1677 2062 1613 3377 1914 3247 2574 2208 3022 1930 M12119 GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 83/217 Gene Ontology BP GO:0046890 1.90405057830515e-08 1.0108602044243e-07 2780 2273.45454545455 2062 1.73095508616753e-09 727 1.77873230476737 2.07301571707018 1 11.5501233990392 2778 1887 922 1498 727 4571 2698 2062 2411 1425 4029 1931 M16810 GO_AMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving AMP, adenosine monophosphate. 10/18 Gene Ontology BP GO:0046033 8.33165403390814e-06 1.46919368322961e-05 2065 2029 2063 7.57425962455574e-07 714 1.12735247089199 1.23144140173522 1 5.05753081073369 2063 714 2058 1626 2544 2768 1472 2721 1053 3223 2077 1932 M12436 GO_GLYCOGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. 11/33 Gene Ontology BP GO:0005978 1.46333412714493e-06 3.10808674946113e-06 1710 2084.81818181818 2065 1.3303046368048e-07 1216 1.90157043489198 2.07673519828232 1 9.72157423923684 1708 3125 2065 2682 2117 2408 1571 1894 1216 2016 2131 1933 M12660 GO_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. 203/446 Gene Ontology BP GO:0097190 1.02400844761865e-08 6.93894745173081e-08 2005 2063.90909090909 2065 9.30916774895436e-10 495 1.41023824161529 1.62158867718088 1 9.37122081385788 2002 898 2233 2058 495 3942 2065 2163 2612 2403 1832 1934 M14077 GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. 13/40 Gene Ontology BP GO:0046460 8.20723960076726e-06 1.44890545499477e-05 2065 2143.36363636364 2065 7.46115474414117e-07 1203 2.26380050628521 -2.13757187057279 -1 10.1685566889406 2961 2062 1203 2065 2541 2150 3533 1723 1351 1294 2694 1935 M15244 GO_GLUCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. 11/33 Gene Ontology BP GO:0009250 1.46333412714493e-06 3.10808674946113e-06 1710 2087 2066 1.3303046368048e-07 1217 1.90157043489198 2.07673519828232 1 9.72157423923684 1709 3126 2066 2683 2118 2409 1572 1902 1217 2023 2132 1936 M16472 GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 13/40 Gene Ontology BP GO:0046463 8.20723960076726e-06 1.44890545499477e-05 2965 2143 2066 7.46115474414117e-07 1204 2.26380050628521 -2.13757187057279 -1 10.1685566889406 2962 2063 1204 2066 2542 2151 3534 1704 1352 1300 2695 1937 M11600 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/67 Gene Ontology BP GO:0043268 5.82891354451289e-09 5.0871514261604e-08 1865 1905.72727272727 2067 5.2990123272333e-10 281 1.49346451242724 1.38922936088487 1 10.1111728977588 1862 814 1186 2067 281 2605 2428 4503 2096 843 2278 1938 M13445 GO_LIVER_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIVER_REGENERATION.html The regrowth of lost or destroyed liver. 12/26 Gene Ontology BP GO:0097421 1.77417663848638e-05 2.9482827961676e-05 1150 2165.09090909091 2068 1.61290086035243e-06 832 1.82958819882773 1.82958819882773 1 7.69417372923836 1149 2958 2475 3638 2708 1750 1570 832 2068 3402 1266 1939 M10335 GO_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMMONIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. 27/89 Gene Ontology BP GO:0060359 1.34211811515068e-08 8.18850776431617e-08 2190 2002.81818181818 2069 1.22010738485302e-09 596 1.99009759568747 2.54637820669585 1 13.0916201231102 2186 2686 1109 2586 596 3089 1736 1977 2654 1343 2069 1940 M10609 GO_SODIUM_ION_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_EXPORT.html The directed movement of sodium ions out of a cell or organelle. 4/15 Gene Ontology BP GO:0071436 5.60278698242022e-05 8.53189241042213e-05 4010 2574.81818181818 2069 5.60292824793182e-06 844 2.19375546547586 -3.29506164215868 -1 8.28590967473252 4008 1881 3611 1701 3209 3634 1830 844 1076 2069 4460 1941 M13752 GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of chemokine production. 36/101 Gene Ontology BP GO:0032722 1.86530194041215e-07 5.35596593032382e-07 3830 2652 2071 1.69572918051318e-08 1195 1.653103050149 -1.42937399776535 -1 9.62314641429543 3826 1599 1446 1385 1544 3524 3550 4532 2071 1195 4500 1942 M10799 GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. 32/65 Gene Ontology BP GO:1901185 2.53876854984972e-07 6.94711321882723e-07 1260 2133.36363636364 2072 2.30797167529093e-08 1127 1.61259675814681 1.7162164573178 1 9.21824816810379 1258 3365 2046 2503 1630 2289 1127 2223 2072 2891 2063 1943 M12017 GO_ORGANOPHOSPHATE_ESTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSPORT.html The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. 42/106 Gene Ontology BP GO:0015748 4.55574588379583e-07 1.12452568519213e-06 2660 2503.72727272727 2072 4.14158802472458e-08 1597 1.5478588366922 1.95160830032271 1 8.54764913898451 2658 1597 1983 1905 1807 4610 3342 2072 1960 2219 3388 1944 M14101 GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 9/18 Gene Ontology BP GO:0046475 1.12625169927118e-06 2.46892664764687e-06 2635 2171.63636363636 2072 1.12625227007089e-07 228 2.24010488565634 2.96754383252165 1 11.6602036622484 2631 1415 4187 1544 2072 3290 2586 1047 228 1659 3229 1945 M16901 GO_FLUID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLUID_TRANSPORT.html The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 16/31 Gene Ontology BP GO:0042044 4.5359348217224e-06 8.42750915456466e-06 2725 2256.27272727273 2073 4.12358561262535e-07 458 2.33498081056365 2.07424314542599 1 10.9983783457477 2721 837 458 1259 2413 3262 2073 4529 1602 1692 3973 1946 M11149 GO_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that modulates the frequency or rate of macrophage activation. 11/34 Gene Ontology BP GO:0043030 5.10428143080191e-05 7.82926286197993e-05 2335 2181 2075 4.64036350955226e-06 873 1.76866078032544 -1.8749850443269 -1 6.74158697730866 2332 3486 2075 3224 2920 873 1414 1761 2643 2006 1257 1947 M11917 GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. 6/26 Gene Ontology BP GO:0051156 4.99440414351446e-05 7.66832620315399e-05 1045 1998.36363636364 2075 4.99451639539251e-06 494 0.852015861662733 -0.852015861662733 -1 3.25475448466683 1042 2075 3822 2355 3097 494 1101 833 2771 3422 970 1948 M12130 GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS.html Any process that modulates the frequency, rate or extent of removal of superoxide radicals. 4/10 Gene Ontology BP GO:2000121 6.4274405436026e-08 2.32962958353193e-07 3910 2337.81818181818 2076 6.42744072950657e-09 101 2.23936103149079 -1.13676243937132 -1 13.7874663751133 3907 246 3855 101 1220 4568 4342 1865 164 2076 3372 1949 M15328 GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 7/18 Gene Ontology BP GO:0060457 0.000378141373433313 0.000521795397869154 1060 2029.36363636364 2076 3.78205734751946e-05 485 2.75558851193107 2.75558851193107 1 8.39630487385058 1056 2200 4388 1585 3264 2076 2262 1260 485 2749 998 1950 M14221 GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is decreased. 14/46 Gene Ontology BP GO:0045776 0.000806387754169334 0.00107218165595882 1830 2195.72727272727 2077 7.33348617464366e-05 1136 3.04105188078064 2.66690750711874 1 8.38320652195886 1829 2889 1136 2008 3325 2895 2077 2293 1557 1905 2239 1951 M14475 GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 7/15 Gene Ontology BP GO:0009312 0.000138809763092046 0.000200402279240165 1520 2241.54545454545 2077 1.38818434522035e-05 1187 1.53066145547205 1.58120544309372 1 5.2544420929244 1517 1187 4242 2262 3096 1853 1361 2077 2803 1973 2286 1952 M10124 GO_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ACTIVATION.html A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. 245/670 Gene Ontology BP GO:0045321 4.42321849530627e-08 1.81102323401297e-07 2610 2302.72727272727 2079 4.02110780385225e-09 907 1.74237794059935 2.16072659724882 1 10.9044845264384 2608 2079 907 1614 1031 4055 2984 2449 2042 1885 3676 1953 M10574 GO_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_PROCESS.html Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. 1040/2967 Gene Ontology BP GO:0002376 1.21299573048433e-08 7.66338738749247e-08 1490 2020.09090909091 2079 1.21299573710544e-09 222 1.65491493110873 1.92346262660672 1 10.9308784898989 1488 1503 3606 2186 593 4156 1933 2079 2264 222 2191 1954 M10971 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 16/75 Gene Ontology BP GO:0071379 9.07785496889457e-05 0.000134230830001839 1290 2286.45454545455 2079 8.25293597259704e-06 1287 1.44830485732577 1.44830485732577 1 5.20572269646545 1287 2627 2079 2252 3016 1855 1908 2032 3486 2690 1919 1955 M12741 GO_REGULATION_OF_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBRINOLYSIS.html Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. 4/20 Gene Ontology BP GO:0051917 0.000554217202670463 0.000749775778554476 1555 2139.63636363636 2079 5.54355471724433e-05 607 1.91391399925512 1.91391399925512 1 5.55202099439303 1592 2499 3954 2128 3758 1122 607 1552 2690 2079 1555 1956 M14360 GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 29/68 Gene Ontology BP GO:0030166 4.76180490234633e-07 1.16670502172e-06 1470 2140.45454545455 2079 4.32891448456248e-08 1253 1.62392184866931 1.6510682966052 1 8.9435812237202 1469 2849 1580 2501 1825 2079 1253 3209 2470 1852 2458 1957 M14875 GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune effector process. 89/270 Gene Ontology BP GO:0002699 1.75032203821957e-07 5.0823922598208e-07 1360 2429 2081 1.59120197952306e-08 1244 1.56500142955089 -1.30699485703503 -1 9.14336180260301 3516 1356 1244 1610 1520 2081 4557 4393 2660 1360 2422 1958 M12711 GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized during embryonic development. 16/43 Gene Ontology BP GO:0048596 1.26814712949741e-06 2.73860796384022e-06 3495 2025.63636363636 2082 1.15286169136064e-07 691 1.73055450812118 -1.37131674483677 -1 8.93556683403911 3492 691 1168 1021 2082 2202 3836 3135 741 913 3001 1959 M16250 GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that increases the frequency, rate, or extent of monocyte chemotaxis. 8/23 Gene Ontology BP GO:0090026 3.4925157372344e-05 5.50619713683508e-05 905 2126.63636363636 2082 3.49257062794633e-06 770 2.68706223275229 2.68706223275229 1 10.6235487501477 901 3830 4535 2276 3052 1285 808 770 2082 2153 1701 1960 M11248 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD.html The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). 14/61 Gene Ontology BP GO:0043153 3.50470533521328e-07 9.07541244238639e-07 4125 2559.18181818182 2083 3.18609626684522e-08 1056 1.60568551688308 -1.00100095917016 -1 9.00575127999842 4123 1556 1657 2083 1721 4240 3303 2246 1056 1896 4270 1961 M12758 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of cellular response to hypoxia. 10/15 Gene Ontology BP GO:1900037 2.17807092028132e-06 4.36271927647376e-06 2485 2134.72727272727 2083 1.9800664333134e-07 480 2.30350770684312 2.30350770684312 1 11.461547555794 2481 2018 2083 1856 2239 3486 2866 2045 1451 2477 480 1962 M13946 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. 4/13 Gene Ontology BP GO:0040015 3.44490420516839e-08 1.5075108599997e-07 3330 2068.18181818182 2085 3.44490425857152e-09 292 1.77989873752699 -1.69944639047078 -1 11.2709250999437 3330 738 4162 1801 988 1515 2090 2368 292 2085 3381 1963 M13654 GO_RECEPTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 44/123 Gene Ontology BP GO:0043112 6.06107647095494e-10 1.07822138140398e-08 2105 2022.36363636364 2086 5.51006952056797e-11 2 1.50906160966673 1.5325607901585 1 11.1605820007704 2103 1724 1540 2086 2 2973 1922 3699 2095 1239 2863 1964 M16464 GO_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLATION.html The covalent attachment of a mannose residue to a substrate molecule. 16/31 Gene Ontology BP GO:0097502 1.47916479702584e-05 2.48741838195978e-05 2050 2495.18181818182 2087 1.34470431113544e-06 939 0.723805066217691 -0.70710918976526 -1 3.09349727975431 2050 1811 3251 3333 2671 939 1641 2087 3380 4628 1656 1965 M15987 GO_O_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_GLYCAN_PROCESSING.html The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. 22/65 Gene Ontology BP GO:0016266 1.28479539443108e-06 2.76427479904704e-06 4315 2758.09090909091 2089 1.16799649522683e-07 1205 1.63426907793491 -1.58750573194838 -1 8.43225943054879 4314 1953 1755 1981 2089 3111 4428 3677 1976 1205 3850 1966 M14941 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 22/70 Gene Ontology BP GO:0009948 6.4044422454417e-09 5.40651369919742e-08 1370 2221.18181818182 2091 5.82222024007794e-10 313 1.69185948288377 1.70439813435582 1 11.4128346835633 1367 3954 2091 3473 313 2096 1875 1702 3207 2399 1956 1967 M15621 GO_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_P38MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of p38MAPK cascade. 19/45 Gene Ontology BP GO:1900744 6.33606208723981e-07 1.49483416011456e-06 1870 2245.36363636364 2091 5.76005810185846e-08 1311 1.57281135103097 1.96612975388132 1 8.50495536952053 1870 2472 1711 2343 1894 2091 1311 2761 3393 3029 1824 1968 M15732 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY.html Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. 4/17 Gene Ontology BP GO:0010715 3.76859473047713e-05 5.91134639648828e-05 1695 2359.81818181818 2093 3.76865864238066e-06 1695 1.34201249234992 1.59862907470719 1 5.26735844331963 1695 2029 4449 1880 2879 2270 1784 1846 2677 2093 2356 1969 M15838 GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 17/27 Gene Ontology BP GO:0033598 2.43748957011281e-07 6.68869035108378e-07 3300 2436.27272727273 2093 2.21589985470405e-08 471 1.87879393865697 1.8557303740011 1 10.768649864401 3298 2093 1353 1115 1624 4221 2943 3537 471 1816 4328 1970 M14794 GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. 21/54 Gene Ontology BP GO:0048169 3.30799046460711e-08 1.46137009773271e-07 1890 1791.90909090909 2097 3.00726410395193e-09 797 1.43758397115221 1.73157895584488 1 9.1212867440848 1886 2139 2164 1300 944 2232 797 2097 1050 2771 2331 1971 M14939 GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. 6/15 Gene Ontology BP GO:0043558 6.01080844649214e-06 1.09058943403919e-05 2605 2318.54545454545 2099 6.0108247049722e-07 1158 0.793530792370873 -0.626540839819821 -1 3.65526869068355 2602 1264 4321 2002 2497 1158 1886 2099 1953 3451 2271 1972 M13109 GO_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ADAPTATION.html A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 22/50 Gene Ontology BP GO:0043500 5.76855407210264e-05 8.76420044397007e-05 1750 1953.81818181818 2100 5.24427757562087e-06 701 2.68477756471298 3.18161682029455 1 10.1114455535061 1748 2423 701 1518 2946 2534 2100 2280 1298 1200 2744 1973 M14817 GO_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 141/332 Gene Ontology BP GO:0051260 2.07515139181142e-08 1.05829926808989e-07 2415 2000.18181818182 2100 1.88650128307755e-09 303 1.53866549385089 1.75201626687819 1 9.96281201441701 2413 303 1014 1835 767 4225 2644 2748 2100 1421 2532 1974 M15788 GO_SNRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_PROCESSING.html Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. 14/23 Gene Ontology BP GO:0016180 0.000187826793972249 0.000268002398406009 1680 2421.81818181818 2100 1.70766210686285e-05 1231 0.779465464345591 -0.746008777431043 -1 2.58440501078778 1679 2100 3114 2480 3129 1231 1839 1692 3539 3977 1860 1975 M13086 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. 118/306 Gene Ontology BP GO:1904950 1.15745088932185e-06 2.5289621078218e-06 1375 2073.36363636364 2101 1.05222863479406e-07 924 1.36753876551399 1.61597099660634 1 7.10507322642306 1373 2543 2224 2744 2051 2486 1411 924 3011 2101 1939 1976 M15467 GO_NEGATIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSSIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. 42/94 Gene Ontology BP GO:0030279 2.59937979459099e-07 7.08685871185319e-07 1805 2141.54545454545 2101 2.36307281974291e-08 1262 1.83898134028018 1.51081209118887 1 10.4975880684444 1801 2419 1262 2101 1637 2888 2196 4206 1418 1369 2260 1977 M13556 GO_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSPORT.html The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 165/504 Gene Ontology BP GO:0015711 2.69969587220649e-07 7.28870891404062e-07 1655 1982.90909090909 2103 2.45426927590503e-08 420 1.79030319480375 2.10249751266794 1 10.1994456532936 1511 1654 420 2103 1655 3898 2453 2662 2383 475 2598 1978 M12185 GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. 11/33 Gene Ontology BP GO:1903409 3.22388626476094e-08 1.43789663086312e-07 4060 2379.45454545455 2104 2.93080573818533e-09 932 2.560011378014 -2.74173810795027 -1 16.2596573123691 4056 2104 1600 1076 932 2747 4102 3785 1025 2015 2732 1979 M14425 GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. 33/76 Gene Ontology BP GO:0009168 9.42481719382855e-07 2.11296118932622e-06 1485 2317.27272727273 2104 8.56801930130001e-08 1147 0.85080687981103 -0.900724159025694 -1 4.48202508682214 1483 2131 3121 2691 2001 1147 1850 1660 3620 3682 2104 1980 M15156 GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 33/76 Gene Ontology BP GO:0009127 9.42481719382855e-07 2.11296118932622e-06 1485 2319.36363636364 2105 8.56801930130001e-08 1148 0.85080687981103 -0.900724159025694 -1 4.48202508682214 1484 2132 3122 2692 2002 1148 1851 1673 3621 3683 2105 1981 M15297 GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 224/577 Gene Ontology BP GO:0051090 1.07731755614578e-07 3.45918769929795e-07 2105 2309.63636363636 2105 9.7937964445538e-09 1364 1.37451277713794 1.64140306893272 1 8.2436471187843 2105 1583 2168 1718 1364 4429 2098 2307 2846 1769 3019 1982 M15444 GO_MYOTUBE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_CELL_DEVELOPMENT.html The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 11/39 Gene Ontology BP GO:0014904 0.0215968928520419 0.0251314219328397 1570 2185.72727272727 2105 0.00198289680924887 400 4.69221782805636 5.3730444617881 1 6.96800342652102 1566 4052 1371 1923 3889 2206 1415 2105 400 2671 2445 1983 M13201 GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER.html The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. 9/16 Gene Ontology BP GO:0006390 4.52919256181641e-05 7.00267767716071e-05 1265 2101.81818181818 2106 4.52928487559812e-06 365 0.971369906625212 -0.971369906625212 -1 3.74625367630661 1262 2106 4031 2560 3406 583 365 813 3068 3750 1176 1984 M16246 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. 16/42 Gene Ontology BP GO:1901381 1.2375975289276e-07 3.86947160054604e-07 2535 2090.18181818182 2106 1.12508872595269e-08 1162 1.65211310345643 -1.85698510612432 -1 9.83390515617513 2534 1162 1332 2106 1404 3360 2819 1996 2149 1271 2859 1985 M13605 GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 10/20 Gene Ontology BP GO:0036109 3.87583448975479e-08 1.63298543883226e-07 2310 1824.18181818182 2107 3.52348596185186e-09 229 0.783174493479967 -0.810631400977514 -1 4.9340851515324 2308 229 2707 2107 999 795 1644 2437 2899 3206 735 1986 M12639 GO_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that modulates the frequency, rate or extent of receptor internalization. 17/56 Gene Ontology BP GO:0002090 2.93412665820357e-06 5.70244875430689e-06 3295 2167.27272727273 2108 2.66739142857982e-07 1242 1.3929016073531 -1.16474996589414 -1 6.78027279508686 3294 1242 2108 1286 2316 1438 1962 2771 1889 2828 2706 1987 M12740 GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 16/55 Gene Ontology BP GO:0032689 1.39067908748237e-06 2.96733593896169e-06 2475 2124.54545454545 2108 1.2642545150625e-07 1139 2.23017571981159 2.25743020861633 1 11.4431987492285 2474 2007 1139 1141 2108 3398 2161 2778 1893 1683 2588 1988 M14288 GO_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_POLYMERIZATION.html Assembly of actin filaments by the addition of actin monomers to a filament. 20/38 Gene Ontology BP GO:0030041 3.29526816009297e-05 5.2253859519507e-05 1270 2274.54545454545 2108 2.99574319934055e-06 1266 1.84684946587116 -1.96652045291326 -1 7.34066297729209 3396 1746 1418 2108 2827 2963 4397 1268 1266 1354 2277 1989 M10689 GO_PHOTOPERIODISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOPERIODISM.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. 15/67 Gene Ontology BP GO:0009648 3.64678532705344e-07 9.38062286621005e-07 4570 2556.54545454545 2109 3.31525993777777e-08 1404 1.60568551688308 -1.00100095917016 -1 8.98433990865964 4566 1404 1613 2235 1735 3592 3713 2109 1413 2037 3705 1990 M10948 GO_ROUNDABOUT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUNDABOUT_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 5/15 Gene Ontology BP GO:0035385 0.000390909695237495 0.00053857380266697 1630 2205.81818181818 2110 3.90978476942238e-05 235 3.53462399194782 3.53462399194782 1 10.7249356643055 1630 3709 3661 2670 3503 2110 1769 1180 235 2262 1535 1991 M14216 GO_DETECTION_OF_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_VISIBLE_LIGHT.html The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 15/83 Gene Ontology BP GO:0009584 5.67150172074857e-06 1.03590804443098e-05 2450 1918.63636363636 2110 5.15592394698128e-07 590 2.05475128176122 2.32256055963979 1 9.50748329906456 2446 1323 980 1313 2462 3604 2110 2579 743 590 2955 1992 M12566 GO_EMBRYONIC_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_FORELIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 17/50 Gene Ontology BP GO:0035115 1.52412240117564e-08 8.78206701948561e-08 2370 2366.63636363636 2113 1.38556582884955e-09 646 1.94778631038132 1.9935591445998 1 12.7583301405346 2368 1614 1547 2113 646 3432 2371 4542 1908 1811 3681 1993 M13496 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune system process. 722/2113 Gene Ontology BP GO:0002682 3.06217910089768e-08 1.38980425859901e-07 1820 2197.72727272727 2114 3.06217914309391e-09 415 1.72936784017139 2.04108162384797 1 11.0076243049331 1819 742 4086 1948 949 4643 2273 2175 2114 415 3011 1994 M10979 GO_NOTCH_RECEPTOR_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_RECEPTOR_PROCESSING.html The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. 9/20 Gene Ontology BP GO:0007220 1.30335565343621e-06 2.80031480745226e-06 4110 2121.27272727273 2115 1.30335641786803e-07 268 1.85081418905393 -0.735101988351046 -1 9.53989178578544 4107 579 3664 506 2115 2397 3355 1179 268 3065 2099 1995 M11332 GO_GANGLIOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 11/27 Gene Ontology BP GO:0001573 0.0035324438223343 0.00440535500056357 2450 2367.18181818182 2115 0.000321648045067915 1312 1.61721885875523 1.41994364654246 1 3.53685063223222 2447 1694 1712 1312 3516 3152 2115 3663 1431 2008 2989 1996 M16166 GO_EPOXYGENASE_P450_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPOXYGENASE_P450_PATHWAY.html The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. 2/57 Gene Ontology BP GO:0019373 0.00178474645405348 0.00229291028947712 1895 2503.5 2116.5 0.000198462638300394 834 0.897442443077854 -0.897442443077854 -1 2.19895304132615 1892 2207 4520 NA 3526 1283 834 1966 4194 2587 2026 1997 M11632 GO_CARTILAGE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_MORPHOGENESIS.html The process in which the anatomical structures of cartilage are generated and organized. 8/20 Gene Ontology BP GO:0060536 1.98627985033919e-05 3.26660632372559e-05 1435 2049.45454545455 2118 1.98629760444693e-06 584 1.97637823248878 1.63738970405982 1 8.22979640557229 1432 2837 3778 1191 2748 1617 584 3099 1014 2126 2118 1998 M14965 GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 15/40 Gene Ontology BP GO:0061028 1.370570816424e-05 2.31908174222181e-05 1105 2106.27272727273 2118 1.2459812317935e-06 933 1.62628718589662 1.28507815383502 1 6.99659109429648 1102 2788 1757 2118 2655 1140 933 3649 2594 3180 1253 1999 M11123 GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS.html A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism. 697/1598 Gene Ontology BP GO:0044711 8.38877091469282e-09 6.2020801523756e-08 600 1926.27272727273 2120 8.38877094635999e-10 450 1.44064033642103 -1.1574152390514 -1 9.63844786279471 2352 600 3695 2061 450 599 2436 2653 2120 2384 1839 2000 M12623 GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 27/98 Gene Ontology BP GO:0071384 1.48099599366317e-06 3.13984675734159e-06 1660 2054.81818181818 2121 1.34636090058271e-07 674 3.0497414354166 -2.50056333106687 -1 15.5789755082187 1660 3033 674 1320 2121 2599 1471 3360 1806 2433 2126 2001 M13138 GO_POSITIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of exocytosis. 46/117 Gene Ontology BP GO:0045921 4.22432485247445e-08 1.74964676985182e-07 4325 2511.72727272727 2121 3.84029539417067e-09 798 1.56563795399629 -1.30419861682656 -1 9.82013780675533 4324 798 1844 1653 1017 3059 4294 3511 2121 1115 3893 2002 M15603 GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. 10/24 Gene Ontology BP GO:0070861 6.05910811054636e-05 9.17262437472017e-05 1860 2300.27272727273 2121 5.50843181209474e-06 626 0.971240941612393 -1.01280076464582 -1 3.64006653535186 1860 2068 2542 3395 2953 626 1082 2121 4138 3819 699 2003 M16330 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 12/38 Gene Ontology BP GO:0035774 7.76292151831579e-06 1.38043832284719e-05 1805 2225.63636363636 2122 7.05722628245576e-07 1068 1.85069128061384 2.20515687345853 1 8.34906534120828 1802 2634 2122 3095 2528 2037 1068 1946 3237 2814 1199 2004 M11337 GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY.html The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. 4/34 Gene Ontology BP GO:0007214 0.000371505291117666 0.000513362817458132 1470 2490.54545454545 2124 3.71567413016217e-05 544 1.3092464332345 1.3092464332345 1 3.99788585166097 1467 3197 3732 3280 3557 1321 544 1988 4114 2072 2124 2005 M12798 GO_MAINTENANCE_OF_LOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION.html Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. 83/197 Gene Ontology BP GO:0051235 9.42117772209742e-09 6.64805736677504e-08 4040 2630.63636363636 2124 8.56470705676565e-10 455 1.41580258382596 -1.04318653524634 -1 9.43263978930932 4036 2084 2096 1707 455 2124 3764 3343 2800 1886 4642 2006 M15786 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 10/22 Gene Ontology BP GO:1902043 2.74046574672193e-07 7.36767948004049e-07 2265 2074.18181818182 2124 2.49133280735687e-08 1035 1.07873038855707 -1.15835922778381 -1 6.14089378397787 2261 1754 2593 2124 1662 1035 2902 1396 2786 3216 1087 2007 M16214 GO_RUFFLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. 17/42 Gene Ontology BP GO:0031529 1.51953402512278e-06 3.20836583840158e-06 2595 2196.63636363636 2126 1.38139552241984e-07 1176 1.77946374625658 -0.853914876144658 -1 9.07453731238239 2594 2145 1776 1213 2126 3483 2823 2011 1176 1817 2999 2008 M12054 GO_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_PRECURSOR_CELL_PROLIFERATION.html The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. 49/155 Gene Ontology BP GO:0061351 2.13018192333467e-08 1.0762170478828e-07 1725 2044.72727272727 2127 1.93652903996407e-09 779 1.90912301953681 2.08990069769771 1 12.3485917316941 1722 3262 1373 2176 779 2215 1214 3490 2309 1825 2127 2009 M16306 GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of a defense response. 213/564 Gene Ontology BP GO:0031349 2.21723790577904e-08 1.10933573238492e-07 4555 2579.45454545455 2127 2.01567084375014e-09 794 1.71593606553179 -1.4094901721324 -1 11.0780529552536 4553 1651 1274 1774 794 2127 4570 4337 2175 1553 3566 2010 M11933 GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. 8/17 Gene Ontology BP GO:0003161 5.20700385573974e-08 2.02141462392973e-07 2285 1974.54545454545 2129 5.20700397774773e-09 220 2.36773844350865 2.63637772541409 1 14.713328317751 2284 585 3828 1139 1129 2954 2860 3362 220 2129 1230 2011 M12501 GO_METALLO_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLO_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. 14/22 Gene Ontology BP GO:0031163 1.55649672358565e-06 3.28013458533444e-06 1950 2200.90909090909 2129 1.41499802255078e-07 791 0.803867549057603 -0.92326397168368 -1 4.09222631095942 1949 2435 3008 3033 2129 791 1622 839 3573 3610 1221 2012 M14731 GO_BEHAVIORAL_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_COCAINE.html Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. 5/15 Gene Ontology BP GO:0048148 6.01914071466133e-07 1.42723108674977e-06 2130 2406.81818181818 2129 6.01914234501442e-08 256 4.49755165121319 4.49755165121319 1 24.4043579755796 2129 4027 4283 1615 4110 2332 1626 256 909 3288 1900 2013 M13758 GO_IRON_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. 14/22 Gene Ontology BP GO:0016226 1.55649672358565e-06 3.28013458533444e-06 1950 2205.63636363636 2130 1.41499802255078e-07 792 0.803867549057603 -0.92326397168368 -1 4.09222631095942 1950 2436 3009 3034 2130 792 1623 879 3574 3613 1222 2014 M14099 GO_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. 526/1416 Gene Ontology BP GO:0006629 8.13098735304739e-09 6.11821929118504e-08 3790 2278.81818181818 2130 8.1309873827982e-10 436 1.60325513949243 -1.42368811632664 -1 10.735203532255 3789 747 4185 1647 436 1315 4339 3257 2130 508 2714 2015 M16820 GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. 15/23 Gene Ontology BP GO:1900025 1.67097587800157e-06 3.47907668231448e-06 855 1879.09090909091 2131 1.51907013378794e-07 725 1.36243018255864 1.53810940147908 1 6.90334478207764 855 3008 2131 2552 2155 1510 838 725 2897 2611 1388 2016 M13368 GO_GRANULOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_MIGRATION.html The movement of a granulocyte within or between different tissues and organs of the body. 33/100 Gene Ontology BP GO:0097530 4.60164369331546e-05 7.10759536529064e-05 2135 2171.09090909091 2132 4.18339995154618e-06 1327 2.14037408317962 2.46982413356354 1 8.24188585683286 1876 2134 1388 2035 2898 3529 2714 1327 2132 2211 1638 2017 M14696 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. 18/33 Gene Ontology BP GO:0034723 0.00381270382596938 0.00474213336832998 665 2344.63636363636 2132 0.000347211590727939 661 1.7217337348707 -1.7217337348707 -1 3.714292777671 661 3180 2069 3038 3697 1541 2132 1624 3317 2416 2116 2018 M10827 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. 49/123 Gene Ontology BP GO:1903428 8.88907734639003e-08 2.98207992191394e-07 1300 2240.45454545455 2133 8.0809797323203e-09 656 1.50424387601616 -1.36205225943627 -1 9.11171013937972 2762 656 1598 1298 1298 4084 2552 2133 2906 1824 3534 2019 M11433 GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. 34/79 Gene Ontology BP GO:0032922 8.17808518488674e-08 2.79402866176815e-07 1705 2215.27272727273 2133 7.43462317171966e-09 1273 1.34857440312804 1.63510799661503 1 8.20418005095148 1705 2133 2006 1638 1273 3116 2313 3191 2639 2679 1675 2020 M12235 GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. 13/19 Gene Ontology BP GO:0031065 1.07875298652114e-05 1.8619517161404e-05 1590 2224.27272727273 2133 9.8068934194482e-07 584 2.15112360612627 2.59190503228989 1 9.44492557006045 1588 3846 2133 2713 3945 2499 1810 584 732 2957 1660 2021 M14592 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 25/80 Gene Ontology BP GO:0051926 1.57588126558535e-06 3.31527717087122e-06 3365 2571.27272727273 2133 1.43262035855042e-07 1146 1.61616191679038 -1.42531870261823 -1 8.22040772809211 3361 1146 1476 1219 2133 4626 3587 3424 2036 1845 3431 2022 M15799 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. 18/33 Gene Ontology BP GO:0006335 0.00383395618896939 0.00476473730872186 665 2345.81818181818 2133 0.000349150363599372 662 1.7217337348707 -1.7217337348707 -1 3.71099214781576 662 3181 2070 3039 3698 1542 2133 1625 3318 2419 2117 2023 M11834 GO_ERBB2_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB2_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 26/61 Gene Ontology BP GO:0038128 0.0205175741345769 0.0239114198561346 2140 2316.81818181818 2136 0.00188286007289675 1499 2.11889152748509 2.30807023909847 1 3.18908849295864 2136 2948 1841 1784 3738 2662 1733 2355 1499 2786 2003 2024 M13392 GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. 8/14 Gene Ontology BP GO:2000052 1.90146531836974e-06 3.88066086733657e-06 2280 2084.18181818182 2136 1.90146694537836e-07 1099 1.71477149478205 -1.20415551380531 -1 8.61311985557231 2279 1099 4067 1221 2229 2757 1425 2157 1638 2136 1918 2025 M15526 GO_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_DEVELOPMENT.html The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 78/190 Gene Ontology BP GO:0001890 2.38698343531684e-09 3.26925194400475e-08 2555 2130.63636363636 2136 2.16998494355155e-10 61 1.96625257873459 1.76171764430331 1 13.6625652771319 2552 781 536 1373 61 4287 2654 4075 2136 1029 3953 2026 M10929 GO_ACTIVATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_GTPASE_ACTIVITY.html Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. 52/108 Gene Ontology BP GO:0090630 4.24330066969483e-08 1.75593984040937e-07 2405 2282.54545454545 2137 3.85754613776226e-09 1018 1.7930300005027 1.97239603808534 1 11.243811847201 2405 2878 1436 2137 1018 3641 2086 2396 1475 2032 3604 2027 M13725 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 14/61 Gene Ontology BP GO:0071380 4.62035709896301e-05 7.13412637528609e-05 1575 2263.90909090909 2139 4.2004128516499e-06 1573 1.44830485732577 1.44830485732577 1 5.5747764583123 1573 2009 2028 2218 2900 2139 2277 1984 3384 2444 1947 2028 M12220 GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. 6/20 Gene Ontology BP GO:1902991 2.27607015532239e-07 6.31289948098081e-07 3160 2136 2140 2.27607038844471e-08 554 1.63899492679438 -1.23989928953723 -1 9.43240411964084 3158 731 3871 1024 1628 2140 3409 2170 554 1722 3089 2029 M16049 GO_STRIATED_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_ADAPTATION.html Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 19/42 Gene Ontology BP GO:0014888 3.38414467892795e-05 5.35534551610854e-05 2020 1995.45454545455 2140 3.07654248779337e-06 726 2.84484655515856 3.56910885421292 1 11.2792224027931 2016 2140 726 1510 2836 2718 2300 2697 881 1225 2901 2030 M12421 GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. 18/47 Gene Ontology BP GO:2001258 4.39374630661536e-08 1.80213463795187e-07 2305 2125.18181818182 2143 3.99431490396854e-09 1026 1.35610489942927 1.66892133756756 1 8.48972611417619 2301 1314 1803 1593 1026 3257 2143 2950 2598 1928 2464 2031 M12839 GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. 12/25 Gene Ontology BP GO:0060716 9.81297197275009e-07 2.1852100177208e-06 1625 2151.09090909091 2143 8.9208875907017e-08 1360 1.04042281196908 1.16066146943555 1 5.46681414745286 1625 1406 2315 2094 2011 2290 1360 2908 2708 2802 2143 2032 M16438 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 7/17 Gene Ontology BP GO:0032230 1.9626147755937e-07 5.55635390431801e-07 3390 2332.18181818182 2145 1.96261494892727e-08 728 1.26575778690574 -1.52329275430023 -1 7.34956507159869 3388 728 4565 1911 1592 2682 3769 878 2676 1320 2145 2033 M16828 GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION.html Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. 17/26 Gene Ontology BP GO:2000615 1.48862227249146e-05 2.49879725639113e-05 1200 1980.45454545455 2145 1.35330213208837e-06 424 1.47452296671571 1.47421528687974 1 6.29930544145395 1199 2923 2145 2926 2678 976 424 1136 3217 2838 1323 2034 M11818 GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrate derivative. 518/1241 Gene Ontology BP GO:1901135 3.80269885211742e-09 4.13781862527793e-08 4440 2363.81818181818 2146 3.80269885862464e-10 178 1.4812661997742 -1.09486455120868 -1 10.1519286990123 4440 255 3812 2146 178 1131 4058 3438 2128 1214 3202 2035 M11342 GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. 63/351 Gene Ontology BP GO:0002460 8.3211027722597e-09 6.1818164081492e-08 3070 2287.45454545455 2147 7.56463891248433e-10 411 1.79494489077008 -1.18336853440408 -1 12.0112521773832 3066 1664 1033 3024 411 4244 3016 1749 2147 1227 3581 2036 M11744 GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. 17/82 Gene Ontology BP GO:0021515 0.00483233695107012 0.00595291601587121 2150 2311.27272727273 2147 0.000440271274164176 1668 2.12518475551205 2.17117255555154 1 4.38983882043089 2147 3054 1668 2367 3554 2664 1986 2413 1674 1809 2088 2037 M13644 GO_OUTER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 15/61 Gene Ontology BP GO:0036158 4.79100984500362e-07 1.17262302110447e-06 3350 2244.81818181818 2147 4.35546444396124e-08 794 1.84566928207477 -2.14140648178274 -1 10.1610676238543 3348 2147 2013 2170 1827 2533 4315 794 1344 2605 1597 2038 M14028 GO_NEURON_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_CELL_CELL_ADHESION.html The attachment of a neuron to another cell via adhesion molecules. 4/22 Gene Ontology BP GO:0007158 2.72601566010904e-05 4.38106289715689e-05 4545 2591.27272727273 2148 2.7260491009126e-06 658 1.97718905820274 -2.19696237648663 -1 7.99919823191738 4544 881 4174 1132 2811 4379 4227 1698 2148 658 1852 2039 M14980 GO_VACUOLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_FUSION.html Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. 17/25 Gene Ontology BP GO:0097576 1.64654292033905e-06 3.44054850546093e-06 445 1811.54545454545 2149 1.49685832060014e-07 104 0.679605420115957 -0.679605420115957 -1 3.44656717929059 444 2273 3240 2868 2149 152 104 790 3267 4029 611 2040 M15667 GO_MECHANOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of a mechanical stimulus. 8/22 Gene Ontology BP GO:0007638 1.03380056871479e-07 3.35425299828286e-07 4230 2244.18181818182 2150 1.03380061680826e-08 33 2.20713683697375 -1.43406360971712 -1 13.2647235334093 4227 1185 4437 285 1376 2476 2672 1555 33 2150 4290 2041 M11967 GO_SYNAPTIC_VESICLE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYCLE.html A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. 42/129 Gene Ontology BP GO:0099504 1.18125977857904e-06 2.57734452628877e-06 4100 2916 2151 1.07387310258248e-07 1091 1.5442748993784 -1.39797781692983 -1 8.01151132153416 4099 1991 1904 2151 2054 3937 4447 4428 2065 1091 3909 2042 M11035 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. 13/36 Gene Ontology BP GO:0045686 4.26778883116595e-07 1.0647685944709e-06 1885 2182.27272727273 2153 3.87980878097841e-08 1000 1.56435061863411 2.00288991367101 1 8.67315657596921 1883 2153 2104 2219 1787 2792 2275 2345 1000 3501 1946 2043 M12610 GO_PROTEIN_HETEROTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTETRAMERIZATION.html The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. 23/43 Gene Ontology BP GO:0051290 0.000149836663039492 0.000215919188855481 1120 2250.36363636364 2153 1.36224426385713e-05 1117 1.4458789426863 -1.46996007882957 -1 4.91993102775395 1117 2424 2027 2815 3092 1528 2444 2128 2976 2050 2153 2044 M12725 GO_RESPONSE_TO_INSULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSULIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 111/299 Gene Ontology BP GO:0032868 3.86022319334332e-08 1.62788522131635e-07 2480 2406.09090909091 2155 3.509293873706e-09 998 1.69910671804477 1.74147691537713 1 10.7067014899155 2478 1018 1359 1454 998 4511 2787 4042 2155 1582 4083 2045 M15337 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. 11/42 Gene Ontology BP GO:0032743 1.38945416850846e-06 2.96608538132634e-06 2440 2173.09090909091 2155 1.26314095095174e-07 845 1.40091958707566 -1.2591904886782 -1 7.18846137613768 2436 2155 2167 2818 2107 1504 3444 1584 3390 1454 845 2046 M13454 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. 93/259 Gene Ontology BP GO:0031348 2.32905004380029e-09 3.21544141938251e-08 1825 1970.54545454545 2156 2.11731822387814e-10 58 1.67342052718943 2.09899019873501 1 11.6390092604664 1821 2610 1765 2206 58 3704 2418 620 2122 2156 2196 2047 M15003 GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 43/87 Gene Ontology BP GO:0030148 4.60302624110193e-07 1.13438698712507e-06 3250 2749 2157 4.18457018562394e-08 659 1.33415539783581 -1.26234415830227 -1 7.36283127996166 3249 659 2002 1505 1811 4406 3958 4592 2157 1401 4499 2048 M10333 GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. 21/51 Gene Ontology BP GO:0031109 6.73272784842523e-07 1.57085705528836e-06 2160 2493.54545454545 2158 6.12066355351234e-08 1665 1.66047585368617 1.83264152882414 1 8.94579360877661 2158 2049 1665 1904 1914 3943 3565 3299 2475 1826 2631 2049 M10149 GO_LABYRINTHINE_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_DEVELOPMENT.html The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. 25/64 Gene Ontology BP GO:0060711 2.35231383779275e-09 3.2312997481869e-08 4410 2253 2159 2.13846712755266e-10 60 1.62004918751174 1.20725702515955 1 11.2645866615754 4409 1230 1652 2159 60 3696 3835 1366 782 2221 3373 2050 M10840 GO_ICOSANOID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_TRANSPORT.html The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. 7/31 Gene Ontology BP GO:0071715 0.00241126911754749 0.00304805949163436 1250 2222.90909090909 2159 0.000241388951858555 882 1.91213109743209 1.91213109743209 1 4.46573941839378 1247 2159 3646 2413 3577 1842 882 1574 2745 1961 2406 2051 M13716 GO_FATTY_ACID_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_TRANSPORT.html The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/31 Gene Ontology BP GO:1901571 0.00241126911754749 0.00304805949163436 1250 2267.27272727273 2160 0.000241388951858555 883 1.91213109743209 1.91213109743209 1 4.46573941839378 1248 2160 4120 2414 3578 1843 883 1572 2746 1969 2407 2052 M15001 GO_CONVERGENT_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONVERGENT_EXTENSION.html The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. 10/25 Gene Ontology BP GO:0060026 1.73189208995639e-05 2.88214156762277e-05 1565 2266.63636363636 2160 1.57445974906477e-06 1153 1.5665593599575 1.50652366022904 1 6.60235800966722 1562 3849 2407 2060 2706 2160 1153 2154 2455 2489 1938 2053 M11192 GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 36/108 Gene Ontology BP GO:0051055 3.85358583843257e-09 4.15796396971137e-08 2795 2333.27272727273 2161 3.50325985925694e-10 156 1.67305781345587 1.72847878362086 1 11.4631059528292 2792 2129 1739 2011 156 3920 2186 2161 1679 2840 4053 2054 M14403 GO_POTASSIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_IMPORT.html The directed movement of potassium ions into a cell or organelle. 12/35 Gene Ontology BP GO:0010107 1.84485676936194e-05 3.05480384456044e-05 1495 2280.81818181818 2161 1.677156581802e-06 1179 1.61779545525144 1.28234221786999 1 6.78034977966342 1493 3012 2031 3448 2717 1449 1220 4044 2335 1179 2161 2055 M15384 GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. 12/37 Gene Ontology BP GO:0099601 9.32328833475455e-06 1.62066745556965e-05 3750 2088.27272727273 2162 8.4757525870583e-07 113 1.83605886688849 -1.8511688695818 -1 8.1643008019943 3750 699 1085 759 2581 3416 3869 3355 113 1182 2162 2056 M15814 GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 14/56 Gene Ontology BP GO:0007215 1.82812442944963e-07 5.27531493221542e-07 3330 2259.18181818182 2164 1.66193143760046e-08 849 1.67873983543044 -1.70604246621346 -1 9.78265318685164 3328 849 1649 2306 1532 3678 2164 2428 2016 1025 3876 2057 M10643 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. 11/31 Gene Ontology BP GO:2001014 8.34330065430246e-07 1.88965585063055e-06 3540 2424.72727272727 2165 7.58482165311392e-08 1381 1.77721954889512 -1.3379109948831 -1 9.4423653631177 3538 1407 1845 2441 1982 2165 2971 4489 1381 2003 2450 2058 M12328 GO_OVARIAN_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVARIAN_FOLLICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. 31/77 Gene Ontology BP GO:0001541 1.03385204136708e-06 2.28470967542472e-06 4130 2438.36363636364 2165 9.3986593382575e-08 1374 1.85974899584388 -2.11472095104293 -1 9.73851135761635 4128 2223 1442 1957 2029 2346 4056 1774 2165 1374 3328 2059 M10996 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. 20/51 Gene Ontology BP GO:1900077 0.00196902600573511 0.00251366173896841 1845 2422.09090909091 2166 0.00017916277442234 1352 2.02104802932421 2.2594551222995 1 4.87716951944233 1843 3209 1964 3283 3865 2166 1759 1904 2666 2632 1352 2060 M16905 GO_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_EFFECTOR_PROCESS.html Any process of the immune system that can potentially contribute to an immune response. 252/940 Gene Ontology BP GO:0002252 4.11184350510325e-09 4.28055816013327e-08 2755 2364.27272727273 2166 3.73803955708034e-10 172 1.57344788644624 1.96963804408495 1 10.7621876848304 2751 1937 1697 3080 172 3906 2768 2101 2166 1634 3795 2061 M16706 GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. 116/236 Gene Ontology BP GO:2001235 4.00926038834566e-08 1.67702666514314e-07 1775 2193 2167 3.64478223764552e-09 1005 1.55585290349298 1.78683162371243 1 9.78535206405154 1775 2712 2434 2291 1005 3500 1591 2146 2167 3013 1489 2062 M13142 GO_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_IMPORT.html The directed movement of the hexose monosaccharide glucose into a cell or organelle. 9/18 Gene Ontology BP GO:0046323 1.59743864909878e-06 3.35303239049079e-06 2375 1961.54545454545 2168 1.59743979741455e-07 414 1.50220136143966 1.62293133883674 1 7.63390375746613 2375 580 4020 1352 2168 2640 1663 2513 414 1655 2197 2063 M11902 GO_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/164 Gene Ontology BP GO:0002028 4.79621645941203e-08 1.90597891726138e-07 2385 2262.54545454545 2169 4.36019687634023e-09 930 1.55153356554566 -1.44532441658917 -1 9.67814110132378 2385 930 1271 2169 1067 3182 1983 4579 2684 1487 3151 2064 M14537 GO_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. 116/208 Gene Ontology BP GO:0007033 2.47152394439462e-08 1.19664562756508e-07 2100 2469.72727272727 2169 2.2468399746911e-09 495 1.03163703706607 -0.885355613390912 -1 6.62872206974487 2096 2169 3281 3956 840 495 2128 2936 3624 3844 1798 2065 M16037 GO_INACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INACTIVATION_OF_MAPK_ACTIVITY.html Any process that terminates the activity of the active enzyme MAP kinase. 18/28 Gene Ontology BP GO:0000188 6.19181426200958e-08 2.28921327882059e-07 2625 2088.27272727273 2169 5.62892221479615e-09 573 1.53172560221951 1.35076827193338 1 9.44145013796559 2622 1613 1875 2349 1159 2562 573 2222 2169 1938 3889 2066 M14562 GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 11/34 Gene Ontology BP GO:0045663 0.00124684800852489 0.00162569932703765 2215 2282.90909090909 2170 0.000113414110882228 1041 2.23417404814299 2.24468153341209 1 5.78400127606642 2215 3612 1817 2688 4196 2354 1041 1409 1588 2022 2170 2067 M14931 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. 20/60 Gene Ontology BP GO:0035088 2.62810204467282e-07 7.14837597739653e-07 3170 2639.36363636364 2170 2.38918396238527e-08 1136 1.80084422358194 2.13711422747287 1 10.2736125217623 3169 1548 1782 1847 1640 4594 3452 4100 1136 2170 3595 2068 M13958 GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 6/18 Gene Ontology BP GO:0001574 0.000546085546248209 0.00073899014608873 1445 2382.18181818182 2171 5.4621978691895e-05 605 1.72681391821115 1.72681391821115 1 5.01935430025675 1443 3024 4166 2429 4125 1768 605 1886 2171 3442 1145 2069 M15632 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. 20/60 Gene Ontology BP GO:0061245 2.62810204467282e-07 7.14837597739653e-07 3170 2639.72727272727 2171 2.38918396238527e-08 1137 1.80084422358194 2.13711422747287 1 10.2736125217623 3170 1549 1783 1848 1641 4595 3453 4094 1137 2171 3596 2070 M15379 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. 59/148 Gene Ontology BP GO:1903426 2.25590151746389e-08 1.12142941601551e-07 2465 2095.36363636364 2172 2.05081958236011e-09 511 1.48959519629838 -1.28598714844588 -1 9.61028907591863 2461 511 1435 1502 805 3900 2400 2172 2971 1427 3465 2071 M16553 GO_SIALYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLATION.html The covalent attachment of sialic acid to a substrate molecule. 6/21 Gene Ontology BP GO:0097503 0.000546085546248209 0.00073899014608873 1445 2422.09090909091 2172 5.4621978691895e-05 606 1.72681391821115 1.72681391821115 1 5.01935430025675 1444 3025 4580 2430 4126 1769 606 1884 2172 3461 1146 2072 M16821 GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS.html The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. 25/72 Gene Ontology BP GO:0048701 1.25811082889101e-08 7.8408168839476e-08 3765 2530.90909090909 2172 1.14373712371432e-09 573 1.88148597719799 1.97017026537098 1 12.4100417179582 3765 1058 1660 2172 573 4276 2966 3966 1487 1465 4452 2073 M13024 GO_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 45/116 Gene Ontology BP GO:0048145 2.49011869625306e-07 6.82396315314281e-07 2465 2253.18181818182 2174 2.2637445255479e-08 1059 1.81964667509031 2.12255430516552 1 10.4149488009643 2464 2174 1059 1288 1626 4175 2541 3071 1406 1304 3677 2074 M15280 GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. 899/2144 Gene Ontology BP GO:0071822 1.39320164238223e-08 8.34913705328072e-08 4445 2766 2174 1.39320165111677e-09 651 1.54816632717688 -1.18607135330841 -1 10.1723032826072 4441 1582 4379 1898 651 1878 4384 4239 2174 1088 3712 2075 M13914 GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. 278/639 Gene Ontology BP GO:0010256 1.18500007586559e-08 7.55763097835705e-08 3220 2447.27272727273 2175 1.07727280204403e-09 551 1.56113991341855 1.89630224221173 1 10.3202308294991 3218 755 1851 2784 551 2027 3489 4208 1874 2175 3988 2076 M10673 GO_ENERGY_RESERVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_RESERVE_METABOLIC_PROCESS.html The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. 28/89 Gene Ontology BP GO:0006112 2.81358353665876e-05 4.51086614665284e-05 2160 2365.90909090909 2177 2.55783592751647e-06 1375 1.42353580679696 1.74515178876036 1 5.74250349120165 1375 3425 2483 3415 2794 2158 1447 2177 2160 2571 2020 2077 M11001 GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. 12/22 Gene Ontology BP GO:0042219 3.92018264132589e-07 9.91902343524584e-07 3575 2567.54545454545 2178 3.56380303623989e-08 1564 1.53573823179021 -1.26073629230121 -1 8.5584100692601 3572 1564 2067 2585 1762 1860 3116 3698 1801 2178 4040 2078 M14202 GO_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of endocytosis. 131/321 Gene Ontology BP GO:0030100 1.01791412419691e-07 3.31894331365609e-07 2180 2084.54545454545 2179 9.25376519358733e-09 665 1.69694293784172 1.89000722015813 1 10.2057367866239 2179 1434 665 1516 1341 4067 2826 2468 2398 667 3369 2079 M13395 GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 6/24 Gene Ontology BP GO:0071872 0.000700370696506613 0.000935775868742504 1700 2561.81818181818 2181 7.00591528067378e-05 1266 0.677266622625474 0.762625817823892 1 1.90415984699802 1699 1266 4068 2181 3320 1545 1971 2587 3235 4465 1843 2080 M16593 GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. 417/956 Gene Ontology BP GO:0034622 1.82280268148242e-06 3.74646872515401e-06 1020 2490.63636363636 2181 1.65709471978298e-07 749 1.42783603623948 -1.22784917161636 -1 7.1921295720906 1016 4152 3393 3496 2181 749 1825 1957 2809 4111 1708 2081 M16487 GO_ADIPOSE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADIPOSE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. 23/50 Gene Ontology BP GO:0060612 1.22708581097715e-05 2.09770229026763e-05 2025 2388.09090909091 2182 1.11553877754677e-06 1683 1.89910385632435 1.76234394836054 1 8.24711108067223 2023 1741 2020 2653 2626 2505 1798 4574 1683 2464 2182 2082 M10107 GO_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 258/813 Gene Ontology BP GO:0050865 1.06828576472815e-07 3.43778532267579e-07 2185 2109.45454545455 2183 9.71168924184038e-09 397 1.70482758886762 1.97578253197137 1 10.2289773589151 2183 1200 476 1669 1359 4545 2691 2781 2266 397 3637 2083 M10406 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 9/20 Gene Ontology BP GO:0038084 0.00143799115781255 0.00186392879556775 560 2177.36363636364 2183 0.00014389225245024 560 2.20765358689107 2.20765358689107 1 5.59363853504697 560 3129 3580 2183 3876 1299 770 1620 2955 2333 1646 2084 M16796 GO_SPLEEN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLEEN_DEVELOPMENT.html The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. 19/48 Gene Ontology BP GO:0048536 4.22950102524583e-05 6.56775025425298e-05 1960 2197.18181818182 2183 3.84507485419213e-06 1066 1.2657062449358 -0.831088479030038 -1 4.91413013844084 1957 1066 2192 2321 2882 2031 1713 2108 3154 2562 2183 2085 M11888 GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS.html Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. 19/50 Gene Ontology BP GO:0044068 1.28213822942949e-06 2.75983671731161e-06 1975 2477.18181818182 2184 1.16558088786143e-07 1633 2.16747027902636 2.43520846930455 1 11.1847960552878 1972 2886 1727 2992 2088 3778 3034 1633 2184 3023 1932 2086 M13920 GO_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that modulates the frequency, rate or extent of protein acetylation. 42/101 Gene Ontology BP GO:1901983 1.46333784930477e-06 3.10808674946113e-06 1750 2221.54545454545 2184 1.33030802059097e-07 765 1.17711337243005 1.21080507065929 1 6.01786538137175 1750 2352 2384 2715 2119 1594 765 2184 3653 3262 1659 2087 M15585 GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 18/49 Gene Ontology BP GO:0032350 4.54317245452823e-06 8.43757988254982e-06 2785 2194.27272727273 2185 4.130165305966e-07 702 2.04331206356098 2.07982434809837 1 9.62355747204649 2785 1071 1215 776 2414 3288 2185 4065 702 1481 4155 2088 M15727 GO_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMPORT_INTO_CELL.html The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 18/59 Gene Ontology BP GO:0098657 1.84020519625969e-06 3.7755513593609e-06 3170 2118 2185 1.67291521410349e-07 433 2.51117337661343 -1.92840422174361 -1 12.641162352168 3168 2321 1106 1469 2185 2008 3236 2840 433 1482 3050 2089 M16254 GO_AXIS_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_ELONGATION.html The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. 17/43 Gene Ontology BP GO:0003401 3.11831980809917e-08 1.40371965280257e-07 3830 2583.54545454545 2185 2.83483622936256e-09 918 1.68060239528236 -1.78504963631434 -1 10.6904767932846 3830 2185 1775 1575 918 4475 3088 2439 2004 1818 4312 2090 M10218 GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of leukocyte proliferation. 118/335 Gene Ontology BP GO:0070663 1.99725637772007e-07 5.64410308079992e-07 2345 2048.81818181818 2187 1.81568778094525e-08 642 1.65833367257072 1.98170412486685 1 9.61856375285845 2343 765 737 1486 1572 4201 2563 2362 2187 642 3679 2091 M11468 GO_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORELIMB_MORPHOGENESIS.html The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 19/58 Gene Ontology BP GO:0035136 7.32117219728102e-08 2.57321744980891e-07 3315 2699.81818181818 2188 6.6556113099231e-09 1232 1.80403364254272 -1.61450814048565 -1 11.0348841580693 3311 1854 1573 2116 1232 4183 2898 4007 2188 2056 4280 2092 M13963 GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. 15/29 Gene Ontology BP GO:0045683 3.81943300279966e-06 7.22053234201907e-06 3645 2145.36363636364 2188 3.47221784886908e-07 58 3.11602427359159 -1.73209964577482 -1 14.8714721395756 3645 2188 998 694 2377 4150 3893 500 58 2041 3055 2093 M11532 GO_REGULATION_OF_WATER_LOSS_VIA_SKIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WATER_LOSS_VIA_SKIN.html A process that modulates the rate or extent of water loss from an organism via the skin. 17/34 Gene Ontology BP GO:0033561 5.99607721116111e-07 1.42402999956118e-06 4225 2287 2189 5.45098076853306e-08 394 2.73218704904464 2.71339760109773 1 14.8277104607736 4224 556 394 940 2189 4205 3137 4345 696 550 3921 2094 M12291 GO_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by the detection of a hormone. 66/264 Gene Ontology BP GO:0009755 2.78431694591024e-07 7.46827474284301e-07 4535 2517.90909090909 2189 2.53119754390279e-08 1228 1.88713961585363 -1.90631615024712 -1 10.7326120522854 4532 3080 1408 1798 1664 2515 4219 3470 1228 1594 2189 2095 M15923 GO_CELLULAR_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. 10/14 Gene Ontology BP GO:0043482 6.351181310511e-06 1.1465215717225e-05 2860 2329.27272727273 2189 5.7738178598311e-07 1176 0.918126493060519 -0.999310620018895 -1 4.21068639077247 2860 1176 2769 2189 2483 1879 3811 1577 2017 3217 1644 2096 M16896 GO_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. 10/14 Gene Ontology BP GO:0043476 6.351181310511e-06 1.1465215717225e-05 2865 2331.45454545455 2190 5.7738178598311e-07 1177 0.918126493060519 -0.999310620018895 -1 4.21068639077247 2861 1177 2770 2190 2484 1880 3812 1585 2018 3224 1645 2097 M16138 GO_DEFINITIVE_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFINITIVE_HEMOPOIESIS.html A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. 8/21 Gene Ontology BP GO:0060216 4.14731719539132e-05 6.45091917527702e-05 1455 2215.81818181818 2192 4.14739459850406e-06 799 2.09557100507873 2.84976341960445 1 8.15126016056815 1454 2192 4516 2313 3183 1951 1302 799 2543 2942 1179 2098 M15779 GO_LYMPH_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. 9/28 Gene Ontology BP GO:0001945 1.33273246339376e-05 2.26165088725777e-05 1620 2044 2193 1.33274045625241e-06 736 2.54757686755094 2.76370109788555 1 10.9859053705258 1618 2740 4456 2476 2668 1543 736 949 2193 2363 742 2099 M15458 GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 8/32 Gene Ontology BP GO:0045408 1.81517347195172e-05 3.00912554931172e-05 2220 2356.81818181818 2194 1.81518829896848e-06 762 1.19357725168757 -1.27706146215523 -1 5.00965624420383 2218 2194 4409 1737 2730 1895 3044 762 2993 2148 1795 2100 M12335 GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 16/35 Gene Ontology BP GO:0009225 1.40626911093208e-06 2.99372190832537e-06 2640 2298.54545454545 2196 1.27842728167155e-07 1161 0.92146853247151 -1.00196334746782 -1 4.72483533460455 2640 1161 2959 2431 2113 2080 3743 1776 2575 2196 1610 2101 M12792 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. 25/56 Gene Ontology BP GO:0010882 1.23152654593571e-05 2.10219770322777e-05 870 1849.54545454545 2196 1.1195758544437e-06 541 1.86865058654178 1.67207478809921 1 8.11325104471005 868 2590 1701 2401 2628 739 541 3535 2196 2223 923 2102 M10204 GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. 33/70 Gene Ontology BP GO:2000242 6.64109381091494e-07 1.55416323407651e-06 2745 2541.36363636364 2197 6.03735983240803e-08 1338 1.67416846964813 1.67284362855273 1 9.02677331662317 2744 2774 1519 1338 1909 3472 2197 4534 1756 1855 3857 2103 M12978 GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. 6/26 Gene Ontology BP GO:0002827 0.000758739810983342 0.00101114493180128 1620 2445.09090909091 2197 7.58998994284058e-05 657 1.68158222998454 1.68158222998454 1 4.67531756785931 1616 3165 3988 3268 3395 1242 657 2197 3565 1728 2075 2104 M12691 GO_SPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 73/149 Gene Ontology BP GO:0006665 1.13082801711645e-07 3.60854603675031e-07 4540 2706.90909090909 2198 1.02802552294769e-08 917 1.38832648218271 -1.28982715992443 -1 8.30283628631088 4539 917 2198 1542 1375 3125 4628 3896 2143 1362 4051 2105 M13200 GO_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of B cell differentiation. 16/36 Gene Ontology BP GO:0045577 5.60757911948929e-06 1.02544268813662e-05 1185 1809.18181818182 2198 5.09781219336042e-07 579 1.50804533147526 -1.65635062643458 -1 6.98400824261372 1184 2239 2282 2866 2459 579 1084 787 3288 2198 935 2106 M13389 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 16/54 Gene Ontology BP GO:0030813 0.0189260444200573 0.0221288401516812 2110 2769.63636363636 2199 0.00173553170254991 1852 1.49664486896012 -1.50055396848488 -1 2.29930568539534 2107 3449 2186 3186 4160 2199 1852 2019 3873 3256 2179 2107 M11394 GO_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 39/100 Gene Ontology BP GO:0005976 6.38593682326793e-07 1.50507130306767e-06 1530 2173.72727272727 2200 5.80539879719422e-08 1354 1.41646776118399 1.72073279032825 1 7.65563228241434 1527 3144 2206 3625 1898 2274 1614 1354 2200 2379 1690 2108 M16073 GO_POSITIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 198/563 Gene Ontology BP GO:0051047 3.59677214663987e-07 9.27767393158274e-07 2420 2120.81818181818 2200 3.2697933951591e-08 454 1.83265695956335 2.24244308770146 1 10.2624730257276 2419 1508 519 1657 1727 4477 2987 2200 2434 454 2947 2109 M15390 GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 9/22 Gene Ontology BP GO:0046135 4.6712608902227e-06 8.64434607943562e-06 2345 2133.09090909091 2201 4.67127070955698e-07 434 2.12069376590099 2.9459689437539 1 9.96731069148952 2342 1181 4394 461 2440 3614 3313 1418 434 1666 2201 2110 M11175 GO_RENAL_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. 6/19 Gene Ontology BP GO:0072087 2.35099469968511e-07 6.48969583272173e-07 3580 2411.45454545455 2202 2.35099494840807e-08 132 2.86747751415632 2.21092540486502 1 16.4703837284094 3578 2202 3702 1031 1636 3577 2845 2082 132 1721 4020 2111 M12567 GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. 10/24 Gene Ontology BP GO:2000269 7.02289656378663e-06 1.25605965892378e-05 2030 2041.54545454545 2202 6.38447180232526e-07 101 1.99416947310495 2.48968693821498 1 9.07224957264789 2030 3453 2202 2250 3400 2759 837 521 101 3199 1705 2112 M16457 GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. 13/43 Gene Ontology BP GO:0007212 1.49954961294619e-06 3.17194025189484e-06 1785 2161.27272727273 2202 1.36322785005488e-07 974 1.93970519308343 1.80847007299386 1 9.90063188592762 1782 2277 2103 2515 2123 1970 974 2940 2568 2320 2202 2113 M11050 GO_LYMPHOCYTE_COSTIMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_COSTIMULATION.html The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. 37/114 Gene Ontology BP GO:0031294 1.23064781495043e-05 2.10153793130702e-05 1240 2443.81818181818 2204 1.11877699915289e-06 1236 1.66133653531861 1.73908051657353 1 7.21335132761858 1236 3576 2404 4452 2627 2117 1355 1339 3662 2204 1910 2114 M15310 GO_ENDOPLASMIC_RETICULUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. 21/47 Gene Ontology BP GO:0007029 9.76898185954573e-07 2.17750277358957e-06 2205 2301.18181818182 2204 8.88089654310215e-08 602 1.32857428052871 -0.899608174116819 -1 6.98277425373582 2204 3116 2799 3085 2010 602 1387 3049 2186 3671 1204 2115 M12908 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. 21/56 Gene Ontology BP GO:1901021 2.90852103313696e-06 5.65505157322233e-06 3490 2292.18181818182 2205 2.64411352578991e-07 607 2.05596572746005 -1.76319187754978 -1 10.0148096933471 3486 1395 1370 682 2315 4154 3465 2205 607 1829 3706 2116 M12011 GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION.html Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. 7/24 Gene Ontology BP GO:0071675 2.504098689078e-05 4.04823475396559e-05 2210 2198.18181818182 2207 2.50412690682162e-06 797 2.20366118259783 2.55673432749838 1 8.98563741971769 2207 1762 3841 1415 2791 2880 2157 2403 1430 797 2497 2117 M11726 GO_PEPTIDYL_ARGININE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_MODIFICATION.html The modification of peptidyl-arginine. 9/19 Gene Ontology BP GO:0018195 0.000101249573624027 0.000148907751136002 2055 2532.63636363636 2209 1.01254187084139e-05 1446 0.917697596731905 -0.925621300212446 -1 3.26014229428677 2051 2698 3795 3332 3044 1446 1629 1959 2209 3743 1953 2118 M16475 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. 30/90 Gene Ontology BP GO:1902305 6.27232010116358e-08 2.30162001994041e-07 2175 2364.18181818182 2209 5.70210934544622e-09 1144 1.43094889795786 -1.33768417285525 -1 8.81715153393464 2171 1144 1876 2209 1168 2698 2082 4162 2521 3145 2830 2119 M16529 GO_POST_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. 47/154 Gene Ontology BP GO:0009791 1.00278608922978e-06 2.22240372901855e-06 2860 2504.36363636364 2212 9.11624133010782e-08 347 1.60732224936937 1.60678533465362 1 8.43460356029403 2859 347 1796 2085 2023 4554 3213 3493 2212 1408 3558 2120 M10354 GO_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_GASEOUS_EXCHANGE.html The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. 29/68 Gene Ontology BP GO:0007585 0.0170487247400053 0.0200499566787853 1680 2389.36363636364 2215 0.0015620267142833 1020 2.04225077947721 1.90229020156325 1 3.21874710801734 1676 2778 1020 1868 4219 2987 1990 3258 2321 2215 1951 2121 M11235 GO_CELLULAR_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENTATION.html The deposition or aggregation of coloring matter in a cell. 29/56 Gene Ontology BP GO:0033059 6.30711806759063e-08 2.30219726319366e-07 3605 2350.81818181818 2216 5.73374386218874e-09 674 1.37960689482636 -1.10980196337411 -1 8.50065539164168 3602 674 2488 1654 1175 1749 4223 4295 863 2216 2920 2122 M16686 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of hydrogen ion (proton) across a membrane. 44/121 Gene Ontology BP GO:1902600 1.50912589481228e-05 2.53138422312624e-05 850 2038 2217 1.37194204273364e-06 263 0.869337621924738 -0.740633702348142 -1 3.70935387738228 846 2217 3346 2530 2681 263 661 1604 3458 4128 684 2123 M11024 GO_HEME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_METABOLIC_PROCESS.html The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 21/37 Gene Ontology BP GO:0042168 4.92642288687646e-07 1.20007247973596e-06 3880 2178 2218 4.47856726367489e-08 270 1.54408557392513 -0.677751294838053 -1 8.48633829118545 3878 826 1870 677 1833 2922 4619 2218 270 2235 2610 2124 M10750 GO_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION.html A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 33/59 Gene Ontology BP GO:0006635 0.000176106845272489 0.000251976604807448 1795 2114.27272727273 2219 1.60109949048144e-05 710 1.08571007152076 -0.884920962697935 -1 3.626781241676 1791 942 2861 3032 3121 710 2219 1346 2585 3343 1307 2125 M12485 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. 59/127 Gene Ontology BP GO:2001243 2.92511810700344e-08 1.35272145127659e-07 2220 2329 2219 2.6591983144507e-09 890 1.25676929854753 1.37090985893587 1 8.01318252983231 2219 1835 2558 2017 890 4169 2411 2147 3007 2509 1857 2126 M12174 GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of striated muscle contraction. 51/141 Gene Ontology BP GO:0006942 4.00005657815597e-07 1.01037922832391e-06 1945 2416.54545454545 2220 3.63641573222678e-08 1257 1.85232381315959 -1.83529372456912 -1 10.308906016396 1944 3234 1257 1963 1765 3047 2220 4480 2613 1419 2640 2127 M13196 GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of the same species. 11/65 Gene Ontology BP GO:0051703 6.50794204211589e-07 1.52899180387048e-06 3925 2235.90909090909 2220 5.91631269751556e-08 569 1.57469697962314 -1.12528009815328 -1 8.50080920919399 3921 1169 2220 964 1902 2960 3483 2708 569 2662 2037 2128 M12394 GO_PROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. 656/1551 Gene Ontology BP GO:0070271 1.9646725039939e-08 1.02494094787007e-07 3680 2408.72727272727 2221 1.96467252136361e-09 743 1.54672375813877 -1.277553739134 -1 10.0349599539315 3680 743 3903 2221 785 1311 3849 3664 2079 1274 2987 2129 M14120 GO_SOCIAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOCIAL_BEHAVIOR.html Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. 11/65 Gene Ontology BP GO:0035176 6.50794204211589e-07 1.52899180387048e-06 3925 2236 2221 5.91631269751556e-08 570 1.57469697962314 -1.12528009815328 -1 8.50080920919399 3922 1170 2221 965 1903 2961 3484 2696 570 2666 2038 2130 M16814 GO_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex. 656/1551 Gene Ontology BP GO:0006461 1.9646725039939e-08 1.02494094787007e-07 3685 2484.63636363636 2222 1.96467252136361e-09 744 1.54672375813877 -1.277553739134 -1 10.0349599539315 3681 744 4621 2222 786 1312 3850 3772 2080 1275 2988 2131 M15536 GO_MYELIN_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_MAINTENANCE.html The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. 7/14 Gene Ontology BP GO:0043217 0.00177598434713462 0.00228228489447717 2675 2523.72727272727 2223 0.000177740529984915 1317 1.4933944271081 1.39168071995168 1 3.66197737017506 2672 2196 4419 1781 3436 3193 1873 1969 2223 1317 2682 2132 M16611 GO_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. 10/43 Gene Ontology BP GO:0030224 1.26238714862691e-06 2.72870741670147e-06 2225 2008.45454545455 2224 1.14762533909165e-07 311 2.92391961182243 3.7605153949387 1 15.1016723872444 2224 2833 1419 1928 3316 2693 2430 311 353 2504 2082 2133 M10186 GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 44/102 Gene Ontology BP GO:0070373 2.00451506290011e-07 5.65772853315818e-07 1420 2195.27272727273 2225 1.82228658685469e-08 1312 1.25537763337381 1.316249040584 1 7.28014288294985 1420 2350 2611 2565 1574 1996 1720 1312 2999 3376 2225 2134 M15503 GO_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_CHEMOTAXIS.html The movement of a monocyte in response to an external stimulus. 13/54 Gene Ontology BP GO:0002548 2.04231868108908e-06 4.11923789587169e-06 2905 2350.54545454545 2225 1.85665507002769e-07 469 2.43036801445757 -2.23617630626691 -1 12.1490313332989 2902 1475 554 1732 2225 3954 3102 3588 2110 469 3745 2135 M10732 GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS.html The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. 13/43 Gene Ontology BP GO:0060441 2.53026057821208e-06 4.98430202148439e-06 1520 2115 2226 2.30023953483284e-07 1252 1.77946328098382 -1.02397884203911 -1 8.75851127495316 1520 2756 1831 2285 2280 2226 1252 3338 2012 2295 1470 2136 M12834 GO_FEAR_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEAR_RESPONSE.html The response of an organism to a perceived external threat. 10/47 Gene Ontology BP GO:0042596 1.87385501801311e-05 3.09289329848378e-05 2150 2407 2226 1.70351907164208e-06 675 1.78499998601374 1.78499998601374 1 7.47220444346431 2148 3094 2226 2852 3764 3307 1891 675 1922 3201 1397 2137 M16232 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html The directed movement of a protein to a specific location in the plasma membrane. 55/130 Gene Ontology BP GO:0090002 1.84071740697941e-07 5.29848166187563e-07 2910 2511.18181818182 2226 1.67337960090033e-08 649 1.73381331019993 -1.755224734099 -1 10.1005243899494 2909 649 1568 2226 1537 4567 3247 3523 991 1987 4419 2138 M16382 GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. 18/171 Gene Ontology BP GO:0050853 0.00390312185118063 0.00484939650924048 2035 2259.36363636364 2226 0.0003554603462686 1154 1.90947998767561 1.86914232021818 1 4.10209955464834 2031 2624 2011 1644 3527 2458 1154 2568 2189 2421 2226 2139 M13029 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 12/19 Gene Ontology BP GO:2001241 4.02850486795162e-06 7.56342422236125e-06 2145 2210.27272727273 2227 3.66228385883746e-07 443 2.01010098135862 2.51526365169687 1 9.55576938675929 2143 1963 2227 2365 2907 3573 2462 443 1724 2803 1703 2140 M10580 GO_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. 8/22 Gene Ontology BP GO:0046209 5.4343117663463e-06 9.96505115764055e-06 3045 2492.36363636364 2229 5.43432505567701e-07 1775 2.23418366847683 -2.74173810795027 -1 10.3726579541573 3041 1971 3607 1822 2473 2229 3467 2922 1985 2124 1775 2141 M15348 GO_REGULATION_OF_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPIRATION.html Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. 19/34 Gene Ontology BP GO:0043457 0.00015701571652532 0.000225913843144425 2215 2448.63636363636 2229 1.42751749072157e-05 992 1.80454187547517 2.18454974496102 1 6.10744500172692 2214 3297 2187 2180 3555 3212 1446 992 2596 3027 2229 2142 M14056 GO_BLASTODERM_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTODERM_SEGMENTATION.html The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. 8/27 Gene Ontology BP GO:0007350 2.80845890391478e-08 1.31052006943481e-07 2585 2419.09090909091 2230 2.80845893940827e-09 916 1.80976580784632 -1.65424352846761 -1 11.562221567186 2585 1698 4177 1772 916 2761 2230 4495 1783 1526 2667 2143 M14057 GO_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION.html The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. 20/73 Gene Ontology BP GO:0030101 2.09182728232874e-06 4.20630319266018e-06 4425 2672.90909090909 2230 1.90166297391341e-07 1038 1.56277575274169 -1.16612339926635 -1 7.79889525039683 4423 2053 1989 1602 2230 3366 3230 2213 1038 2639 4619 2144 M13911 GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 148/357 Gene Ontology BP GO:0051091 5.88811439064391e-08 2.20828070401936e-07 2675 2295.72727272727 2231 5.35283140748577e-09 1144 1.48436039236919 1.70255295976729 1 9.17103311792764 2231 1978 1912 1646 1144 4250 2401 2675 2675 1246 3095 2145 M11385 GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 38/160 Gene Ontology BP GO:0001676 4.83145640375364e-09 4.65403570179007e-08 2235 2045 2232 4.39223310396736e-10 222 1.39382511828244 -1.45382861889714 -1 9.48658631435847 2709 1728 1718 2897 222 1518 3168 2232 2379 2232 1692 2146 M13524 GO_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of T cell proliferation. 84/232 Gene Ontology BP GO:0042129 1.89391034981923e-06 3.86694184441983e-06 3820 2687.45454545455 2232 1.72173816384423e-07 1057 1.60795037109964 -1.34064681594604 -1 8.07886407282101 3819 1126 1057 1805 2194 3875 3723 3878 2232 1468 4385 2147 M14546 GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of activated T cell proliferation. 9/28 Gene Ontology BP GO:0042104 1.91919040066914e-06 3.91167736185549e-06 3180 2322.72727272727 2232 1.91919205815246e-07 508 2.35638250888528 -1.07463874605004 -1 11.8283033480335 3178 1257 4250 1592 2232 2193 3333 1709 508 2357 2941 2148 M11232 GO_REGULATION_OF_RUFFLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RUFFLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of ruffle assembly. 16/35 Gene Ontology BP GO:1900027 1.31058578231394e-06 2.81324539402848e-06 2695 2243.72727272727 2233 1.19144233005256e-07 1516 1.21630475536888 1.31092825290339 1 6.2670984417379 2693 1688 2377 1816 2094 2932 1516 2331 2233 1677 3324 2149 M12396 GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. 38/132 Gene Ontology BP GO:0040014 4.37013874124609e-08 1.79403662030111e-07 2830 2308.36363636364 2233 3.97285348005062e-09 858 1.75926756678221 1.68196196547138 1 11.0168700708646 2830 1301 1976 889 1025 3856 2385 4562 858 2233 3477 2150 M14081 GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). 7/24 Gene Ontology BP GO:0007191 0.000931004104163049 0.00122837512237256 1275 2397.54545454545 2234 9.31394380192354e-05 1275 1.80847007299386 1.80847007299386 1 4.88622283635435 1275 1573 4181 2393 3354 2234 1998 2519 2785 1971 2090 2151 M14222 GO_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 161/453 Gene Ontology BP GO:0006066 4.10787059444860e-09 4.28055816013327e-08 4260 2237.54545454545 2234 3.73442782010805e-10 171 1.64920413532142 -1.54461692943101 -1 11.2803510070233 4260 1114 972 2300 171 2109 4438 2561 2234 1257 3197 2152 M16365 GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 20/62 Gene Ontology BP GO:0021680 2.6214757332552e-06 5.14434143258828e-06 3845 2329.81818181818 2234 2.38316259723468e-07 388 2.21242021370098 -1.17835439965819 -1 10.8613357358158 3842 2234 1079 1335 3146 3739 4485 388 674 980 3726 2153 M11843 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). 255/684 Gene Ontology BP GO:0032787 1.59288745411146e-08 8.96457751447213e-08 4265 2201.09090909091 2235 1.44807951422236e-09 46 1.59098033702937 -1.26666704680192 -1 10.4079978168861 4261 46 811 2299 670 1222 4298 4391 2235 734 3245 2154 M12905 GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT.html The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 7/35 Gene Ontology BP GO:0007603 1.81712880629288e-06 3.73811654746028e-06 2725 2355.90909090909 2235 1.81713029217528e-07 874 2.15375967845439 2.09387605348848 1 10.8506056122099 2724 874 3978 1440 2213 3358 2235 3185 1190 1311 3407 2155 M11478 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. 21/48 Gene Ontology BP GO:1902883 1.65568344635834e-06 3.45343137531076e-06 2165 2289.18181818182 2236 1.50516790218137e-07 1441 1.52007034479836 1.54933012543513 1 7.70663106008344 2163 1903 2254 1975 2153 2683 1441 3198 2445 2236 2730 2156 M13674 GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-13 production. 20/65 Gene Ontology BP GO:0032656 0.00759269458143893 0.00918522171485695 1215 2409.27272727273 2236 0.000692638726489354 1198 1.57412373187929 -1.44238087207906 -1 2.97632186780646 1215 3117 2148 3107 3708 1198 2158 2236 3196 2638 1781 2157 M12466 GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. 21/50 Gene Ontology BP GO:0001953 0.000411896429071752 0.000566144203724139 1250 2224.36363636364 2237 3.74521424425495e-05 1246 1.55861056805922 1.52156036035551 1 4.69784608288474 1246 2320 1950 2740 3234 2173 1282 2061 2866 2237 2359 2158 M10581 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. 21/36 Gene Ontology BP GO:2000108 2.39328570933047e-06 4.74467359027387e-06 1940 2224.54545454545 2238 2.17571664807944e-07 815 2.64646564909427 2.98516971505148 1 13.0784600890546 1938 3150 1464 1790 2267 3160 2049 2829 815 2770 2238 2159 M15506 GO_CEREBRAL_CORTEX_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_CELL_MIGRATION.html The orderly movement of cells from one site to another in the cerebral cortex. 17/66 Gene Ontology BP GO:0021795 0.000584551517304568 0.000788612143105102 2340 2300.54545454545 2238 5.31551721367249e-05 1244 1.6959537355967 1.7656031458865 1 4.8852186925514 2337 1956 1892 2217 3427 3189 2616 1244 2238 2257 1933 2160 M15700 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. 21/48 Gene Ontology BP GO:1900408 1.65568344635834e-06 3.45343137531076e-06 2165 2286.72727272727 2239 1.50516790218137e-07 1442 1.52007034479836 1.54933012543513 1 7.70663106008344 2164 1904 2255 1976 2154 2684 1442 3159 2446 2239 2731 2161 M10801 GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. 18/45 Gene Ontology BP GO:0040020 2.18187437683427e-06 4.36845309686999e-06 3160 2642.45454545455 2240 1.98352412794124e-07 1295 1.70048286763959 -1.77315136827746 -1 8.46018054778164 3160 3638 1939 2016 2240 3825 2004 2225 1295 2985 3740 2162 M16279 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that activates or increases the activity of the enzyme nitric-oxide synthase. 15/27 Gene Ontology BP GO:0051000 1.69597599406334e-06 3.52322887715261e-06 2235 2241 2240 1.54179754680869e-07 1529 1.96574723963389 2.20026515053588 1 9.95031926838046 2233 2363 1529 2376 2159 3049 2240 2538 1776 1564 2824 2163 M16157 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. 21/60 Gene Ontology BP GO:0040018 8.3008096679602e-07 1.88408287630992e-06 4410 2722.63636363636 2241 7.54619345448768e-08 1883 1.6888809560864 -2.03154824268972 -1 8.97503344870641 4408 2051 2348 2088 1975 3178 4396 2149 1883 2241 3232 2164 M11199 GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX.html The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. 5/18 Gene Ontology BP GO:0021819 2.16725726718259e-06 4.34856330662436e-06 1390 1963.45454545455 2242 2.16725938083732e-07 146 1.66764080516231 1.66764080516231 1 8.29985386396968 1387 3333 3706 2256 3657 809 146 556 2242 3273 233 2165 M16020 GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. 6/28 Gene Ontology BP GO:0036151 1.98746264968177e-06 4.02608598711714e-06 1850 2366.36363636364 2242 1.98746442718751e-07 448 1.04484269752161 -1.04484269752161 -1 5.23264052943471 1846 3650 4495 3629 2242 782 745 448 3748 3456 989 2166 M16287 GO_MESODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the mesoderm. 4/23 Gene Ontology BP GO:0001710 7.40281813315849e-05 0.000110839356956643 1795 2420 2242 7.40306475244459e-06 1515 0.982373056519107 0.982373056519107 1 3.60682979536344 1793 2671 4541 1819 2997 2242 1743 1515 2520 3125 1654 2167 M16266 GO_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other 398/1247 Gene Ontology BP GO:0055085 5.41658487007167e-08 2.08534026133854e-07 3195 2132.45454545455 2244 4.92416818493866e-09 242 1.56482460397203 1.79413993431918 1 9.70431241680835 3193 892 482 1539 1106 2244 3625 3512 2427 242 4195 2168 M13822 GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. 29/84 Gene Ontology BP GO:1904888 7.8681106323697e-09 6.00371670427235e-08 3645 2532.27272727273 2246 7.15282787319028e-10 388 1.73635910649483 1.83836641426363 1 11.6396761979574 3643 1051 1820 2246 388 4130 3101 3958 1642 1536 4340 2169 M14303 GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-RNA complex into its constituent components. 10/17 Gene Ontology BP GO:0032988 0.000796383688187111 0.00105918346154476 2525 2245 2247 7.24247381238175e-05 1304 1.0515611372019 -1.18950584308918 -1 2.90398798245518 2521 1625 2896 2275 3445 1892 1539 1304 1742 3209 2247 2170 M10577 GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. 12/18 Gene Ontology BP GO:0008535 9.47276487880257e-06 1.64603470554941e-05 1330 2177.09090909091 2248 8.61164151536406e-07 847 0.687289985696753 -0.720247925046951 -1 3.05183076515619 1328 2440 3146 2248 2584 847 1216 1431 3363 3892 1453 2171 M12902 GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 9/15 Gene Ontology BP GO:1902895 2.44135201199008e-06 4.83377287491256e-06 1985 2286.45454545455 2249 2.44135469408407e-07 929 1.39440750653874 1.38979933329777 1 6.88050680101804 1981 3216 3977 2796 2295 1867 1752 1744 2249 2345 929 2172 M11535 GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. 12/36 Gene Ontology BP GO:1902932 0.00115873325777713 0.00151463922180722 3085 2192.54545454545 2251 0.000105394909948527 596 2.5416367219291 -2.88772435272554 -1 6.65248789639641 3082 2329 1578 1706 3494 2251 2756 1389 596 2795 2142 2173 M16497 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 367/874 Gene Ontology BP GO:0031400 3.65620121849661e-09 4.04184339463804e-08 1925 2338.63636363636 2251 3.32381929506626e-10 140 1.52956459027317 1.87287953364933 1 10.4974149155798 1925 3307 2598 2705 140 4431 2055 1166 2251 3300 1847 2174 M11915 GO_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. 39/112 Gene Ontology BP GO:0031016 3.0802585453663e-07 8.12593206030438e-07 3895 2539.09090909091 2253 2.80023543330797e-08 1397 1.69697981885546 -1.30868342708394 -1 9.59339102260387 3895 2718 1662 2253 1688 2112 4358 2381 2170 1397 3296 2175 M15335 GO_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERTILIZATION.html The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). 57/221 Gene Ontology BP GO:0009566 2.2614367898371e-07 6.28733593725368e-07 2255 2327.18181818182 2253 2.05585183845096e-08 402 1.39412254175981 -1.35847796755124 -1 8.02544574485798 2253 3109 2563 4247 1600 402 1840 1684 3597 3500 804 2176 M15060 GO_COCHLEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_MORPHOGENESIS.html The process in which the cochlea is generated and organized. 10/37 Gene Ontology BP GO:0090103 1.94096666559244e-06 3.9473973842951e-06 2455 2200.27272727273 2255 1.76451670729736e-07 442 1.63376180758975 1.68609354203463 1 8.19498624445562 2452 1171 1328 442 2199 3963 2358 4087 2255 868 3080 2177 M14501 GO_CELLULAR_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. 80/207 Gene Ontology BP GO:0009267 1.08451004409819e-08 7.13226647981285e-08 1955 2267.72727272727 2256 9.85918226767612e-10 521 1.55960813726366 1.77017552161495 1 10.3465266340315 1953 2256 1811 2936 521 3951 2285 1497 2229 3171 2335 2178 M16322 GO_REGULATION_OF_MYOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of myoblast proliferation. 6/25 Gene Ontology BP GO:2000291 2.08911965777516e-06 4.20267875695411e-06 4570 2746.18181818182 2256 2.08912162176718e-07 775 1.70028979836235 -1.63158670653639 -1 8.48573793085992 4567 1342 4550 1668 2256 4005 4157 1703 775 1086 4099 2179 M13235 GO_GLYOXYLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYOXYLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. 18/32 Gene Ontology BP GO:0046487 2.33740386053068e-06 4.64579029299827e-06 1315 2233 2262 2.12491485811258e-07 175 0.782850254708141 -0.773239742945622 -1 3.87538225683535 1311 3447 2869 3399 2262 224 175 2131 4178 3841 726 2180 M16772 GO_MALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DIFFERENTIATION.html The establishment of the sex of a male organism by physical differentiation. 97/273 Gene Ontology BP GO:0046661 1.80366111946234e-09 2.66700591645339e-08 4460 2185.54545454545 2263 1.63969192812824e-10 37 1.87004741048078 -1.85314786035608 -1 13.1475756528887 4460 1439 746 1882 37 3198 3765 2316 2263 666 3269 2181 M11277 GO_PH_REDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PH_REDUCTION.html Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. 24/49 Gene Ontology BP GO:0045851 1.13208126675552e-05 1.94388066625218e-05 1050 1940 2264 1.02917008389853e-06 584 1.29733616381037 -1.1584597238689 -1 5.67368490269359 1048 2264 2422 2316 2615 584 1305 1395 3340 3048 1003 2182 M15731 GO_PHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 13/34 Gene Ontology BP GO:0009395 6.50674865130482e-07 1.52899180387048e-06 3810 2664 2264 5.91522779613642e-08 473 2.28876175565581 -1.60997967878998 -1 12.3556007330174 3810 2152 1496 2264 1901 4424 3129 3378 473 1787 4490 2183 M10449 GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any negative regulation of signal transduction that takes place in extracellular region. 3/15 Gene Ontology BP GO:1900116 0.00580401656238715 0.00709532619777871 1325 2433 2266 0.000581923149416979 1323 2.07428671613524 2.07428671613524 1 4.13789919977347 1323 2538 3588 2162 3773 1817 1501 1748 3202 2845 2266 2184 M13296 GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any regulation of signal transduction that takes place in the extracellular region. 3/15 Gene Ontology BP GO:1900115 0.00584261186130307 0.00713874917685004 1325 2476.54545454545 2267 0.000585803019575055 1324 2.07428671613524 2.07428671613524 1 4.13279715886356 1324 2539 4047 2163 3774 1818 1502 1751 3203 2854 2267 2185 M11556 GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. 5/20 Gene Ontology BP GO:2000846 5.8450087404893e-05 8.87164942206337e-05 2400 2236.72727272727 2268 5.84516248475299e-06 852 2.55311643358102 -2.55311643358102 -1 9.60303965386413 2398 2377 3768 1883 3369 1955 3040 852 1133 2268 1561 2186 M10054 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. 32/82 Gene Ontology BP GO:0030858 2.17368164454349e-06 4.35580659284222e-06 3835 2746.36363636364 2270 1.97607617474963e-07 1715 1.27615601394106 -1.27892791834124 -1 6.35057648054053 3831 2176 2216 3286 2237 1715 3368 3484 3515 2112 2270 2187 M16852 GO_ORGANELLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FUSION.html The creation of a single organelle from two or more organelles. 72/149 Gene Ontology BP GO:0048284 2.4584857434648e-06 4.86147755830796e-06 1280 2407.81818181818 2270 2.2349895371009e-07 351 0.99237407448773 -0.896359826914348 -1 4.89444317157538 1278 3600 3347 4412 2270 351 1341 1178 3972 3955 782 2188 M11711 GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 5/17 Gene Ontology BP GO:0009214 0.00130982599380458 0.00170589679922431 1910 2742.54545454545 2271 0.000131059867472437 759 1.47547696250292 1.47547696250292 1 3.79118563710655 1908 3970 3794 4528 4055 1935 759 1498 3376 2271 2074 2189 M15204 GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 8/22 Gene Ontology BP GO:0006700 2.06207443078324e-07 5.78851969898826e-07 3230 2410.63636363636 2271 2.06207462213006e-08 470 1.69418865374105 2.06514974664755 1 9.8092716079376 3227 1571 4369 1164 1601 4432 3243 2271 470 1531 2638 2190 M13229 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. 15/31 Gene Ontology BP GO:0006356 2.46336274023778e-06 4.86697583103149e-06 2245 2458.09090909091 2272 2.23942318044984e-07 1216 2.03134907547047 2.03134907547047 1 10.0177992150137 2245 4103 2811 3419 2272 3134 1398 1216 1720 3178 1543 2191 M10865 GO_BETA_AMYLOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). 11/25 Gene Ontology BP GO:0050435 2.47281400359905e-06 4.88254780189879e-06 4315 2625.63636363636 2273 2.24801525732919e-07 710 1.53049607877188 -1.00551194912075 -1 7.54582203832862 4315 710 1758 2105 2273 3091 3807 3130 2118 2005 3570 2192 M15805 GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-6 production. 76/195 Gene Ontology BP GO:0032675 1.11680725170987e-07 3.57362926925496e-07 4175 2604.90909090909 2274 1.01527937127585e-08 1093 1.61945531784625 -1.42789170143536 -1 9.69144191336282 4174 1517 1457 1817 1370 3699 3520 3847 2274 1093 3886 2193 M12071 GO_HOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. 5/13 Gene Ontology BP GO:0050667 1.87375500989788e-05 3.09289329848378e-05 1070 2294.18181818182 2275 1.87377080939564e-06 496 1.95774192140563 1.95774192140563 1 8.19532102752023 1066 3224 3847 4311 3587 1049 496 680 2980 2275 1721 2194 M12554 GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. 11/26 Gene Ontology BP GO:0051447 1.84229874927731e-06 3.7781771611725e-06 2365 2387.36363636364 2276 1.67481844730527e-07 1345 1.25519347544052 1.05666672674502 1 6.31824985467504 2365 2635 2276 1954 2186 1835 1345 4027 2711 2658 2269 2195 M14130 GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of anion transmembrane transport. 16/44 Gene Ontology BP GO:1903959 2.09223089375741e-05 3.42895447925015e-05 2295 2002.18181818182 2276 1.90204617402903e-06 983 1.48911915378578 1.46473594582839 1 6.17169294325477 2291 1243 2328 2039 2738 2624 1212 2604 983 1686 2276 2196 M10892 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. 26/70 Gene Ontology BP GO:0032272 3.50663147138514e-07 9.07541244238639e-07 3130 2360.81818181818 2278 3.18784730028678e-08 511 1.4981278999745 1.54963705753205 1 8.40249668382017 3127 547 1934 1410 1722 4065 2278 3793 511 2785 3797 2197 M10063 GO_CARDIAC_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_ADAPTATION.html The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. 9/17 Gene Ontology BP GO:0014887 4.04778028910603e-05 6.31089452059076e-05 1550 2364.45454545455 2279 4.04785402135994e-06 1548 2.02284192522961 2.36648511582946 1 7.88625772667992 1548 2793 3529 2645 2889 1795 1760 2265 2279 2331 2175 2198 M10409 GO_SINGLE_ORGANISM_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. 66/146 Gene Ontology BP GO:0044801 2.21873996490847e-06 4.43461457471806e-06 1645 2608.72727272727 2279 2.01703836595563e-07 794 1.16937094736727 -1.09960324659376 -1 5.81072553776588 1641 3312 3142 4352 2246 794 2034 2279 3896 3674 1326 2199 M13805 GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. 9/17 Gene Ontology BP GO:0003299 4.04778028910603e-05 6.31089452059076e-05 1550 2423.09090909091 2280 4.04785402135994e-06 1549 2.02284192522961 2.36648511582946 1 7.88625772667992 1549 2794 4134 2646 2890 1796 1761 2275 2280 2353 2176 2200 M15894 GO_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. 23/67 Gene Ontology BP GO:0048806 8.98994833176958e-06 1.56859564466013e-05 2280 2331.63636363636 2280 8.17271369815142e-07 1119 2.69609008471579 -2.00165843453143 -1 12.0240489907392 2280 3924 1201 1119 2569 3362 1854 3212 2089 1626 2412 2201 M14904 GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION.html A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. 334/995 Gene Ontology BP GO:0003006 2.62305184608545e-09 3.4500934054886e-08 1895 2211.72727272727 2281 2.38459259019354e-10 73 1.77126062374921 1.78642365117367 1 12.2692126074293 1891 2379 568 2572 73 4219 2281 3856 2271 783 3436 2202 M16881 GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. 9/17 Gene Ontology BP GO:0014898 4.04778028910603e-05 6.31089452059076e-05 1550 2468.54545454545 2281 4.04785402135994e-06 1550 2.02284192522961 2.36648511582946 1 7.88625772667992 1550 2795 4630 2647 2891 1797 1762 2248 2281 2376 2177 2203 M10113 GO_LIPID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_MODIFICATION.html The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. 110/244 Gene Ontology BP GO:0030258 1.00530292635235e-08 6.87425844926945e-08 4510 2719.54545454545 2282 9.13911755405582e-10 485 1.52043044274254 -1.26500720560564 -1 10.1092036937034 4507 1281 1849 2224 485 2844 4489 4560 2282 1714 3680 2204 M12080 GO_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. 49/163 Gene Ontology BP GO:0042752 3.01174435853205e-08 1.38040760677831e-07 2870 2324 2283 2.73794945432915e-09 898 1.57015636161877 -1.13925145376886 -1 9.99851925475787 2868 1986 1110 2283 898 4315 2710 2153 2529 1325 3387 2205 M11330 GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. 10/25 Gene Ontology BP GO:1902931 3.26269366273078e-06 6.26496554014021e-06 3020 2191.27272727273 2285 2.96608954677676e-07 163 2.44264474633055 2.35433750559335 1 11.7975019123563 3019 2285 1157 771 2341 4060 3000 1303 163 1863 4142 2206 M10822 GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. 29/53 Gene Ontology BP GO:0043496 3.46132976134798e-08 1.51071062295052e-07 4440 2403.63636363636 2287 3.14666346891471e-09 676 1.54793229791804 -0.862568263527761 -1 9.80071143286721 4438 1048 1746 1067 957 2287 3406 3318 676 3056 4441 2207 M11743 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that modulates the frequency, rate or extent of extracellular matrix organization. 16/44 Gene Ontology BP GO:1903053 1.03549210999977e-08 6.96781140105641e-08 3060 2510.45454545455 2288 9.41356468066914e-10 502 1.26980673262887 1.58017201849978 1 8.43590976158425 3060 1857 2288 1042 502 4045 3853 2224 3536 2194 3014 2208 M14821 GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 25/58 Gene Ontology BP GO:0010799 4.44750330631595e-06 8.27645605259517e-06 2470 2298 2288 4.04319299761848e-07 691 1.53495465987198 1.79968131635338 1 7.24123493857351 2469 2229 1932 1037 2409 3926 2899 2288 691 2225 3173 2209 M15395 GO_KETONE_BODY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BODY_METABOLIC_PROCESS.html The chemical reactions and pathways involving ketone body. 5/14 Gene Ontology BP GO:1902224 3.54222316244563e-09 3.98870630704176e-08 4265 2531.18181818182 2288 3.54222316809193e-10 157 2.79342887979569 -3.57235249104043 -1 19.1862297663206 4262 596 4396 1873 157 3802 4479 1756 378 2288 3856 2210 M14158 GO_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. 71/157 Gene Ontology BP GO:0045444 5.90959512959598e-09 5.10954379640859e-08 1015 2162.09090909091 2289 5.37235922315473e-10 291 1.26180508554628 1.42581402031105 1 8.54053951055164 1015 2346 2289 4017 291 1648 1307 2458 3361 3466 1585 2211 M15460 GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 5/21 Gene Ontology BP GO:0035413 0.00109151311413314 0.00142878358864398 2350 2455.45454545455 2289 0.000109204961544439 1408 1.99878722541637 1.99878722541637 1 5.27865261517272 2348 2378 4411 1503 3373 3324 2033 1927 1408 2289 2016 2212 M11819 GO_REGULATION_OF_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_BINDING.html Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 10/33 Gene Ontology BP GO:0035561 8.84136384534855e-07 1.99467698415711e-06 2185 2163.36363636364 2291 8.03760672592672e-08 489 1.77246740449765 2.21887813780849 1 9.37846915337734 2184 1922 2322 2553 1991 3066 2676 1111 489 3192 2291 2213 M12464 GO_L_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_IMPORT.html The directed movement of L-enantiomer amino acids into a cell or organelle. 5/23 Gene Ontology BP GO:0043092 2.40709533769273e-06 4.77001436317002e-06 2295 2073.81818181818 2291 2.40709794504529e-07 255 3.1744732554697 3.77088179367609 1 15.6809824577604 2646 2295 3912 1265 2291 3312 2988 628 255 1503 1717 2214 M14754 GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. 170/471 Gene Ontology BP GO:0034110 2.83070978746032e-07 7.57084420689992e-07 2260 2367.72727272727 2291 2.5733728651672e-08 687 1.73122818100819 1.99948627132171 1 9.83638653434055 2260 2344 687 2236 1669 4367 2932 2737 2291 820 3702 2215 M14088 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. 48/150 Gene Ontology BP GO:0045621 2.65094966682203e-06 5.19559278305389e-06 2280 2361 2292 2.4099571465101e-07 1472 1.6633083056451 -1.3119199611619 -1 8.15895779054156 2277 1836 1515 2865 2292 1530 2739 4056 2929 1472 2460 2216 M16969 GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. 7/23 Gene Ontology BP GO:0031998 4.17708814757005e-05 6.49070290132789e-05 1815 2342.90909090909 2292 4.17716666594151e-06 1356 1.29984996667396 1.29984996667396 1 5.05287752523329 1811 2292 4642 2340 2897 1829 1428 1356 2688 2763 1726 2217 M14083 GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of plasma membrane organization. 60/137 Gene Ontology BP GO:1903729 3.24873055929586e-08 1.44343119491011e-07 4550 2634.18181818182 2293 2.9533914611543e-09 936 1.52902448527198 -1.37745688158211 -1 9.7090786176983 4546 1130 1479 1220 936 3484 3954 4638 2293 1745 3551 2218 M13439 GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. 49/123 Gene Ontology BP GO:0006767 7.90182962183317e-08 2.71764406919788e-07 3860 2413.81818181818 2294 7.18348173240584e-09 793 1.52016881262449 -1.21736956569634 -1 9.26507825342489 3860 793 1393 2187 1265 2814 3990 2463 2294 1326 4167 2219 M11471 GO_MANGANESE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_TRANSPORT.html The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/14 Gene Ontology BP GO:0006828 2.62504926284843e-06 5.14917774710825e-06 3755 2496.27272727273 2295 2.62505236375121e-07 1521 1.81587033017091 -1.34349450034494 -1 8.91388317827627 2670 1643 3752 3028 2314 1952 2295 3755 1521 2266 2263 2220 M11398 GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of T cell proliferation. 53/158 Gene Ontology BP GO:0042102 2.71917602844314e-06 5.32256926646774e-06 4330 2656.63636363636 2297 2.47198126301899e-07 1329 1.59948632931298 -1.02846222560368 -1 7.83032518872865 4329 1448 1329 2115 2297 3729 3732 1943 2382 1822 4097 2221 M14683 GO_REPLICATIVE_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATIVE_SENESCENCE.html A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. 10/22 Gene Ontology BP GO:0090399 1.45104692147656e-05 2.44197796591822e-05 2300 2029.27272727273 2299 1.31914226562584e-06 876 2.56629211580106 2.56629211580106 1 10.9872458180322 1217 3040 1501 2375 2665 2299 2263 876 1300 2487 2299 2222 M11041 GO_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane. 83/181 Gene Ontology BP GO:0061025 3.78485257028488e-07 9.63964371027575e-07 1640 2568.81818181818 2300 3.44077565584214e-08 734 1.17080805271244 -1.15510620028963 -1 6.53820080529567 1636 3231 3202 4494 1748 734 2166 2300 3788 3698 1260 2223 M16943 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. 51/143 Gene Ontology BP GO:0002705 2.98243689389049e-07 7.90675968926134e-07 3285 2497.90909090909 2300 2.71130663473232e-08 1295 1.41658401895115 -1.15061678242426 -1 8.02386801817519 3285 1295 1914 1682 1680 2300 4405 3220 3163 1988 2545 2224 M11372 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. 430/1043 Gene Ontology BP GO:0019637 3.9334748710089e-09 4.21425504795384e-08 2050 2192.27272727273 2301 3.5758862527652e-10 160 1.368171602913 -1.11466415541704 -1 9.3667336247804 2048 2301 2906 4376 160 319 1946 2647 2753 3632 1027 2225 M11657 GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 49/129 Gene Ontology BP GO:0045428 3.76114768458415e-08 1.59917662083555e-07 2405 2171 2301 3.41922522625929e-09 520 1.49172143211686 -1.32330133033816 -1 9.41058996467697 2404 520 1325 1743 987 3571 2301 2969 3080 1567 3414 2226 M14045 GO_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 155/420 Gene Ontology BP GO:0006631 1.54308683991191e-08 8.82555423854249e-08 4165 2389.90909090909 2301 1.40280622794106e-09 298 1.52704184564839 -1.21323675593369 -1 9.99934175168651 4164 298 1425 2301 656 1754 4372 4067 2441 1467 3344 2227 M14845 GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 37/107 Gene Ontology BP GO:0042108 7.84595654790661e-08 2.70443773214034e-07 3785 2357.45454545455 2302 7.13268802520035e-09 1140 1.3087756216803 -1.39530043361735 -1 7.97925568211563 3784 1140 2353 2214 1262 2551 4381 1618 3074 1253 2302 2228 M12724 GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of natural killer cell activation. 13/34 Gene Ontology BP GO:0032814 5.81768144549809e-07 1.3880521557784e-06 3460 2626.54545454545 2303 5.28880271266066e-08 1486 2.16458841056201 2.86587826977842 1 11.7696553662079 3460 2439 1486 1769 1872 4586 3480 1911 1818 2303 3768 2229 M14563 GO_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. 396/787 Gene Ontology BP GO:0007005 1.64263251609167e-07 4.86399411493216e-07 1555 2591.36363636364 2303 1.49330239885366e-08 751 1.21693167010131 -0.941166184143072 -1 7.13134736844699 1552 3418 3449 4419 1494 751 2097 2303 2874 4247 1901 2230 M11239 GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. 91/245 Gene Ontology BP GO:0022408 1.19990139389471e-06 2.60821262727207e-06 2390 2411.90909090909 2304 1.09082004393918e-07 588 1.85948747529798 2.06458553199959 1 9.63787131103977 2386 2036 588 2304 2062 4243 3001 3586 1911 1055 3359 2231 M11560 GO_SULFATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATION.html The addition of a sulfate group to a molecule. 5/26 Gene Ontology BP GO:0051923 4.9475202215513e-07 1.20298465477503e-06 2865 2377.09090909091 2304 4.94752132305968e-08 27 2.57520948479781 2.33197482132447 1 14.1509085830335 2864 2939 3769 1055 1858 3746 2304 1734 27 2269 3583 2232 M13691 GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that modulates the frequency, rate or extent of regulated secretory pathway. 66/188 Gene Ontology BP GO:1903305 6.12345915137075e-08 2.27631872216288e-07 3680 2445.09090909091 2304 5.56678120164593e-09 606 1.43053488486259 -1.36320331924464 -1 8.82097517916242 3679 785 1459 1623 1155 3393 3613 4036 2304 606 4243 2233 M15905 GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. 27/77 Gene Ontology BP GO:1902930 2.79160650871833e-06 5.448267767961e-06 4380 2599.54545454545 2304 2.53782731911615e-07 777 2.11248440549313 2.11997878166042 1 10.3218419091172 4380 1797 927 1371 2304 3334 4527 4309 777 1632 3237 2234 M14107 GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 10/45 Gene Ontology BP GO:0050996 2.81805828671395e-06 5.49527283713266e-06 3535 2527.54545454545 2306 2.56187445133778e-07 894 1.32688251180103 1.46008833291533 1 6.47870536322718 3531 1096 2110 2084 2306 4385 3978 894 2393 1873 3153 2235 M15401 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 4/13 Gene Ontology BP GO:0034374 5.50938469433646e-07 1.32196760391753e-06 2770 2318 2308 5.50938606023631e-08 131 3.27813536753888 3.00091382006743 1 17.8888807365286 2767 1193 4397 1475 1886 3168 2526 4409 131 1238 2308 2236 M13824 GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. 13/40 Gene Ontology BP GO:0046885 1.39832398326801e-05 2.36087936520486e-05 2095 2103.90909090909 2311 1.27121170101786e-06 437 2.13063015713489 2.03848142056441 1 9.15102570340513 2093 1251 1493 1000 2660 2422 2437 4186 437 2311 2853 2237 M14743 GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. 46/129 Gene Ontology BP GO:0002702 1.433185848628e-05 2.41447093439036e-05 3150 2647 2311 1.30290471379575e-06 1447 1.94584318655423 -1.58799261161528 -1 8.33976069604343 3150 2311 1447 1973 2663 2264 4079 4471 1998 1919 2842 2238 M14396 GO_MRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION.html The cellular synthesis of messenger RNA (mRNA) from a DNA template. 12/33 Gene Ontology BP GO:0009299 0.000614984336695574 0.00082668566163218 1870 2532.18181818182 2312 5.59233014273999e-05 1081 1.28029935544859 1.28029935544859 1 3.66358451746087 1867 3157 2312 3169 3324 2113 1121 1898 3911 3901 1081 2239 M12608 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. 11/24 Gene Ontology BP GO:0048009 0.000147222959919899 0.000212284535064625 1465 2361.54545454545 2313 1.33848011758082e-05 1462 1.28868562714757 1.34030914193758 1 4.39386479115333 1462 2015 2305 2446 3091 2417 2129 2313 3224 2018 2557 2240 M14453 GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. 13/25 Gene Ontology BP GO:0045605 1.77493006506444e-06 3.66429537220729e-06 4280 2432.27272727273 2313 1.61357408823226e-07 121 2.79112313428215 -1.73209964577482 -1 14.084075401847 4279 2631 1268 893 2171 2985 4198 1307 121 2313 4589 2241 M11164 GO_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 13/34 Gene Ontology BP GO:0010874 0.000163459637644077 0.000234676282492719 2205 2405.27272727273 2314 1.48610712665186e-05 1457 1.70265496626538 2.10135721094429 1 5.73649028530349 2203 3056 2314 2347 3109 3034 2074 1457 1473 3502 1889 2242 M15540 GO_CELL_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between cells. 57/122 Gene Ontology BP GO:0007043 4.90906349916854e-07 1.19709988585292e-06 3730 2540.45454545455 2314 4.46278599506693e-08 614 1.92355676592936 -1.73903094877625 -1 10.5738460226309 3726 1666 614 1548 1832 4144 3286 3457 2314 1097 4261 2243 M10271 GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT.html The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. 9/31 Gene Ontology BP GO:0060973 2.03840437415456e-05 3.34664480523325e-05 1960 2248.45454545455 2315 2.03842307231172e-06 1131 1.76799958462866 1.61400044868681 1 7.34483785513418 1959 1569 3561 2509 2752 2052 1605 2599 2681 1131 2315 2244 M11925 GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 8/23 Gene Ontology BP GO:0071732 0.00147703674064181 0.00191240423502508 1405 2508.09090909091 2315 0.000147801939688858 775 2.48881385180857 2.48881385180857 1 6.28026758972716 1403 3617 3825 2817 3701 1440 775 2315 3661 2128 1907 2245 M12118 GO_LEFT_RIGHT_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_PATTERN_FORMATION.html The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 14/39 Gene Ontology BP GO:0060972 8.06628434665372e-06 1.42673364653384e-05 2060 2657.54545454545 2316 7.33301265616336e-07 535 2.18363559958786 2.18363559958786 1 9.82204630398491 2058 4201 2302 3226 4229 3163 2316 535 1809 3609 1785 2246 M15319 GO_PROTEIN_HOMOTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTRIMERIZATION.html The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. 13/23 Gene Ontology BP GO:0070207 6.57279624146505e-05 9.90184716064965e-05 2495 2278.54545454545 2316 5.97544783710669e-06 1496 1.95503502579978 -2.12123706049483 -1 7.26688890245421 2494 2278 1788 1997 2962 1496 2483 2839 1597 2316 2814 2247 M16813 GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS.html The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. 136/356 Gene Ontology BP GO:0045137 1.8658191187023e-09 2.70421771353233e-08 4335 2260.81818181818 2317 1.69619920025882e-10 42 1.88971412200348 1.91130977985903 1 13.2752887837071 2457 1433 565 2317 42 4332 2656 4335 1891 610 4231 2248 M15439 GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 6/19 Gene Ontology BP GO:0050746 9.80839080424695e-07 2.1852100177208e-06 2090 2459.45454545455 2318 9.80839513345349e-08 1269 2.12812027987761 2.12812027987761 1 11.1820292110429 2090 2533 4405 3155 2039 2791 2318 1845 1269 2549 2060 2249 M15613 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. 7/21 Gene Ontology BP GO:0060742 3.24702354563626e-05 5.15592692284171e-05 2030 2613.81818181818 2319 3.24707099084053e-06 201 5.08536425931551 5.08536425931551 1 20.2402052148298 2028 4425 4431 3240 4387 2319 1331 756 201 3577 2057 2250 M16065 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. 18/26 Gene Ontology BP GO:0016601 1.85086853799726e-07 5.32440063316064e-07 1925 2164.18181818182 2319 1.68260790337415e-08 1238 1.03731852179339 1.15940585784198 1 6.04097493818757 1924 1855 2626 2779 1538 2498 1444 1238 3165 2420 2319 2251 M13868 GO_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 23/71 Gene Ontology BP GO:0098900 0.0020123106148565 0.00256680169911504 1850 2545.90909090909 2322 0.000183104873545172 1526 2.19836860886307 2.11382094694018 1 5.2865371505246 1848 4007 1526 2322 3438 2563 1967 4103 1555 1625 3051 2252 M10492 GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that stops or reduces the activity of a transporter. 43/102 Gene Ontology BP GO:0032410 1.2255880480749e-07 3.8465050004516e-07 2825 2591.45454545455 2326 1.11417101486421e-08 936 1.31973413719593 -1.21956095720469 -1 7.8586465008466 2825 936 2218 1662 1400 3894 2205 4608 2725 2326 3707 2253 M10571 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. 11/23 Gene Ontology BP GO:1901017 2.68665274493812e-06 5.26112555662071e-06 2330 2459.72727272727 2326 2.44241456899966e-07 1751 1.30994318949827 1.33809057545805 1 6.41899119482587 2326 1751 1919 2071 2296 2965 2421 3397 3059 2002 2850 2254 M11196 GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. 31/50 Gene Ontology BP GO:0046825 3.64800105094029e-05 5.72992857899721e-05 1100 2465.18181818182 2327 3.31641958441106e-06 764 1.36986461726639 1.65001979485052 1 5.39389095172069 1096 3603 2582 4049 2886 2095 1589 764 2327 3836 2290 2255 M14815 GO_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_FUSION.html The joining of two or more lipid bilayer membranes that surround a cell. 11/32 Gene Ontology BP GO:0045026 3.43337537220416e-06 6.53862258127314e-06 2330 2415.36363636364 2328 3.1212552094799e-07 1841 1.42077267191524 -1.42077267191524 -1 6.83756949262874 2328 1864 2369 2450 2355 1841 2148 2256 3520 3324 2114 2256 M15396 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. 17/46 Gene Ontology BP GO:0032736 0.00657716896471823 0.00799418730449915 1220 2362.63636363636 2328 0.000599719537374414 1220 1.66250576796972 -1.52353610421787 -1 3.2365136471471 1220 2628 1961 2931 3598 1477 2328 2400 3158 2256 2032 2257 M10111 GO_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSPORT.html The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 480/1474 Gene Ontology BP GO:0006811 8.69657624636853e-11 1.7329701078064e-09 2380 2017.54545454545 2329 7.9059784061021e-12 133 1.61252463001942 1.84929974925097 1 13.1141313565822 2378 256 215 1466 922 3770 2875 4456 2329 133 3393 2258 M13057 GO_OVULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION.html The release of a mature ovum/oocyte from an ovary. 8/28 Gene Ontology BP GO:0030728 1.61932140627207e-06 3.39129873221525e-06 1910 2693 2330 1.61932258626409e-07 1789 1.37791635490286 1.81360041623996 1 6.9960071924016 1907 3131 4002 3241 2176 1789 1968 1862 3568 3649 2330 2259 M14956 GO_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid oxidation. 13/43 Gene Ontology BP GO:0046320 0.000196238569635175 0.000279278861403263 1780 2492.09090909091 2330 1.78414614703853e-05 1556 1.30638746222208 1.39858157307373 1 4.30976805088437 1776 2693 2245 2656 3132 2389 1556 2330 4264 2314 2058 2260 M15416 GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 10/21 Gene Ontology BP GO:0009074 2.36883522256715e-05 3.84563004838436e-05 2200 2232.63636363636 2331 2.15350975384163e-06 1544 1.74650870354817 -1.89339490434206 -1 7.15770489222249 2198 1753 1872 2898 2767 1544 2498 2444 2331 1881 2373 2261 M10831 GO_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. 6/28 Gene Ontology BP GO:0046068 0.0175147188208909 0.0205727473330944 1695 2858.27272727273 2332 0.00176543142328995 1692 2.99238259637171 2.99238259637171 1 4.68517776036235 1692 4245 3643 3145 4502 1944 2180 2025 2319 3414 2332 2262 M12925 GO_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. 407/922 Gene Ontology BP GO:0043603 3.13784431487341e-06 6.05025380147725e-06 1210 2437.18181818182 2332 2.85258980942483e-07 332 1.18041608234877 -1.00582972383375 -1 5.71777633434926 1209 3507 3489 4228 2332 332 1377 1888 3146 4241 1060 2263 M11408 GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. 10/19 Gene Ontology BP GO:0035886 0.000110575031800897 0.000161751692706857 1055 2215.36363636364 2333 1.00527808950435e-05 1055 1.47649089650424 1.6286146644073 1 5.19602222905414 1055 2737 2084 2333 3043 1453 1261 2946 2991 2470 1996 2264 M15961 GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS.html The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 11/32 Gene Ontology BP GO:0021692 0.000921268682826488 0.00121656726233316 4095 2674.45454545455 2333 8.37867907487364e-05 845 1.98792433328786 -1.3412603693886 -1 5.37882300111962 4094 2333 1502 2199 3345 4491 4029 1492 845 1008 4081 2265 M12041 GO_BILE_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. 11/33 Gene Ontology BP GO:0006699 3.20811889317137e-06 6.17293660215279e-06 3715 2535.63636363636 2337 2.91647597397721e-07 573 1.68041516463587 -1.03790523929621 -1 8.12610534333666 3715 573 1530 794 2337 4487 4045 3857 606 1445 4503 2266 M10106 GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 12/37 Gene Ontology BP GO:0010831 0.000853373610848298 0.00113109154301132 3625 2728.54545454545 2338 7.76095283516592e-05 711 1.94378250040379 -2.22157154639898 -1 5.31647247571733 3624 711 1836 2091 3334 4220 2248 3404 2338 1596 4612 2267 M15162 GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organonitrogen compound. 560/1252 Gene Ontology BP GO:1901566 2.12801257786508e-07 5.95202554158286e-07 2505 2484.18181818182 2338 2.12801278164479e-08 738 1.32410016145127 -1.07316356828335 -1 7.65160797113154 2501 2116 4363 2721 1614 738 2338 2835 2323 3834 1943 2268 M15761 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 94/249 Gene Ontology BP GO:0007163 6.84448825067995e-08 2.44078025713572e-07 2255 2551.36363636364 2338 6.22226223965542e-09 1204 1.79496480380818 2.0223730378312 1 11.0176474831318 2254 3741 1879 2338 1204 3731 1697 3641 1873 2677 3030 2269 M11765 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 9/20 Gene Ontology BP GO:0034383 1.86090884072595e-07 5.34665825958576e-07 635 1803.18181818182 2339 1.86090899656014e-08 27 1.92834250313284 1.92834250313284 1 11.2267396211783 635 3491 3801 2930 2423 395 27 163 3483 2339 148 2270 M11995 GO_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 60/201 Gene Ontology BP GO:0001816 7.73686690260397e-06 1.37633229995365e-05 1565 2601.45454545455 2339 7.0335401012946e-07 1564 1.68649605802087 1.76478730903297 1 7.61035301203086 1564 3686 1938 3611 2527 2131 1856 2339 3379 3382 2203 2271 M11960 GO_GLUTAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. 9/24 Gene Ontology BP GO:0006541 0.00122294864260284 0.00159678024398341 3260 2538.63636363636 2340 0.000122362218586572 1551 1.27111699007045 -1.27111699007045 -1 3.29996275954449 1551 2529 3833 3259 3387 1737 2069 1864 3256 2340 2100 2272 M15212 GO_MEMBRANE_PROTEIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. 24/63 Gene Ontology BP GO:0033619 3.25236191135751e-06 6.24771053141619e-06 4405 2388.81818181818 2340 2.9566970177134e-07 383 1.63617093954963 -1.02952284861723 -1 7.90420845307389 4403 383 1584 760 2340 2356 4454 3750 544 1752 3951 2273 M10269 GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 11/26 Gene Ontology BP GO:0051284 1.68993748335281e-07 4.95039730927892e-07 2560 2128.09090909091 2341 1.53630692105995e-08 856 1.40617273516904 -0.892885814371752 -1 8.23033832144537 2558 1252 1857 951 1506 3929 2992 2341 856 2647 2520 2274 M16332 GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. 24/56 Gene Ontology BP GO:1904031 3.87387719835797e-05 6.06829009175981e-05 2240 2358.63636363636 2341 3.52176855757547e-06 1080 1.430623106583 1.49185798202781 1 5.60004002625525 2236 3115 2341 2024 2860 2927 1262 1080 3225 3054 1821 2275 M13798 GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION.html The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. 50/170 Gene Ontology BP GO:0099531 2.35427584264448e-07 6.49489170374232e-07 4620 2515.18181818182 2342 2.14025099507414e-08 1118 1.52140632491105 -1.45019278728571 -1 8.73825097003012 4618 1135 1731 1598 1615 2355 4089 4423 2342 1118 2643 2276 M12324 GO_ANATOMICAL_STRUCTURE_REGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_REGRESSION.html The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. 9/20 Gene Ontology BP GO:0060033 0.00631473923730609 0.00768729267929003 2135 2586.63636363636 2343 0.00063327555014623 1271 1.74921221521463 1.6054403982648 1 3.43291576557832 2135 3646 3890 2013 3779 2032 1271 1777 2456 2343 3111 2277 M13388 GO_AMINO_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_METABOLIC_PROCESS.html The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. 20/46 Gene Ontology BP GO:0006040 0.00502446125122923 0.0061764822847385 2210 2466.72727272727 2343 0.000457815742906421 1237 1.44921810858233 1.77037930218322 1 2.97200446864315 2209 1237 2074 1687 3565 3763 3269 2343 1276 2637 3074 2278 M14096 GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 42/106 Gene Ontology BP GO:0008286 3.26322935212362e-05 5.17811820981203e-05 3015 2541.81818181818 2344 2.96661614195924e-06 1251 1.40663044001218 -1.19385382347157 -1 5.59607955300076 3014 1990 2329 1994 2825 1251 3912 2980 2344 2981 2340 2279 M15290 GO_RESPONSE_TO_EPINEPHRINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPINEPHRINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 7/29 Gene Ontology BP GO:0071871 0.00417993371924218 0.00517393555277031 1655 2736.72727272727 2345 0.000418781692705773 1635 0.677266622625474 0.762625817823892 1 1.43727205629107 1651 1635 4381 2345 3549 1758 1928 2586 3512 4565 2194 2280 M12759 GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of female gonad development. 3/17 Gene Ontology BP GO:2000194 2.97508583770137e-06 5.77963328219559e-06 3000 2439.90909090909 2348 2.97508982071996e-07 892 1.77718141263979 1.46617780158222 1 8.64121192100586 2998 1195 3956 2348 2343 3142 2477 2134 1538 892 3816 2281 M14506 GO_AMMONIUM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSPORT.html The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 27/97 Gene Ontology BP GO:0015696 3.35161634871945e-06 6.40656842614426e-06 2950 2292.81818181818 2348 3.04692859526401e-07 1382 1.30628321332044 -1.41737518476306 -1 6.29732515035233 2950 1999 2024 2478 2348 1382 2963 1441 3180 2885 1571 2282 M16140 GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 48/144 Gene Ontology BP GO:0002285 4.7553776660977e-08 1.89684007763674e-07 4365 2706.45454545455 2349 4.32307069898806e-09 1063 1.68541132959071 -1.26555936453977 -1 10.5165082382311 4364 2349 1898 2138 1063 2719 4567 2646 1716 1775 4536 2283 M13083 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. 17/42 Gene Ontology BP GO:0032105 1.23490424865474e-06 2.67677891059943e-06 1865 2330.54545454545 2352 1.1226408562108e-07 1159 1.1885484314579 1.44525516923629 1 6.14790743893494 1864 1159 2700 2482 2069 2558 1808 3990 1822 2832 2352 2284 M15151 GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 12/23 Gene Ontology BP GO:0042776 0.00350411774858966 0.0043732240108607 1160 2558.81818181818 2352 0.000319064683411825 1091 0.483312878764669 -0.483312878764669 -1 1.05842933643136 1160 2441 3286 2296 3513 1091 1573 2352 4139 4554 1742 2285 M16938 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. 17/42 Gene Ontology BP GO:0032108 1.23490424865474e-06 2.67677891059943e-06 1865 2331.63636363636 2353 1.1226408562108e-07 1160 1.1885484314579 1.44525516923629 1 6.14790743893494 1865 1160 2701 2483 2070 2559 1809 3986 1823 2839 2353 2286 M13233 GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 35/75 Gene Ontology BP GO:0009142 0.000108768045688499 0.00015915853644239 780 2387.09090909091 2354 9.88849305047048e-06 776 0.863827860610015 -0.860469154499322 -1 3.04558501215034 776 2354 3282 3302 3040 919 1640 1705 3594 3952 1694 2287 M12702 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 12/37 Gene Ontology BP GO:0090281 1.97986824837545e-06 4.01420448786341e-06 2355 2263.63636363636 2355 1.79988184558232e-07 1250 1.40617273516904 -0.892885814371752 -1 7.04388046148048 2355 1250 1864 1271 2210 3776 2937 2377 1385 2801 2674 2288 M14999 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. 22/62 Gene Ontology BP GO:2000649 4.65556418736489e-07 1.14429775129355e-06 2360 2539.27272727273 2356 4.23233197505421e-08 1801 1.79738697932754 1.79603088300465 1 9.91297411287727 2356 1801 1878 2443 1818 2917 2310 4517 1982 2873 3037 2289 M13054 GO_REGULATION_OF_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_LOCALIZATION.html Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. 734/1866 Gene Ontology BP GO:0060341 2.04837452951478e-08 1.04975088286426e-07 2360 2276.27272727273 2357 2.04837454839606e-09 674 1.57342252758025 1.91843054043672 1 10.1930071448036 2357 1977 4000 2204 804 3141 2621 1913 2422 674 2926 2290 M11591 GO_IRON_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_TRANSPORT.html The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/73 Gene Ontology BP GO:0006826 5.23090970321269e-06 9.61865891168972e-06 1020 1871.72727272727 2359 4.75538376428733e-07 541 1.52928972277472 -1.37818082972723 -1 7.12185433889074 1018 2588 2466 2359 2447 541 1203 1500 2751 2625 1091 2291 M11869 GO_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORT.html The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 311/954 Gene Ontology BP GO:0006812 3.02414378869465e-08 1.3822254686434e-07 2515 2044.81818181818 2359 2.74922166387715e-09 35 1.55414957798799 1.77044769146655 1 9.89576592073368 2512 35 540 1255 899 3750 2843 4576 2359 205 3519 2292 M12735 GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is divided into specific regions along the rostrocaudal axis. 10/21 Gene Ontology BP GO:0021903 3.36607892104016e-06 6.42891996313841e-06 2350 2410.36363636364 2359 3.06007642842972e-07 1492 1.31383903655561 -1.0242362916912 -1 6.33190555544798 2607 2156 2359 2456 2350 3085 1492 1863 3322 2476 2348 2293 M15982 GO_CHROMATIN_SILENCING_AT_RDNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING_AT_RDNA.html Repression of transcription of ribosomal DNA by altering the structure of chromatin. 25/40 Gene Ontology BP GO:0000183 6.49325512515001e-05 9.78519427006541e-05 2250 2476.72727272727 2359 5.90313343651812e-06 1674 1.73939796043969 -1.51769817071486 -1 6.47367332165301 2247 2359 1674 2637 2960 2089 2906 3024 2248 2226 2874 2294 M14375 GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 16/26 Gene Ontology BP GO:2001269 1.85722270276351e-06 3.79871586296518e-06 3360 2436.72727272727 2360 1.68838570056197e-07 677 1.80880824974435 -1.17543680233333 -1 9.10101960481496 3357 1402 2032 1224 2191 4333 3062 3466 677 2700 2360 2295 M15133 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of natural killer cell activation. 9/23 Gene Ontology BP GO:0032816 1.59469357900775e-07 4.74930230104745e-07 4190 2901 2360 1.5946936934449e-08 1401 1.97117989624403 -1.1126536217374 -1 11.5702835718838 4187 1921 4359 1401 1521 4101 3949 2114 1749 2360 4249 2296 M11638 GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. 4/15 Gene Ontology BP GO:0045628 4.52201483276331e-05 6.9939090168288e-05 2460 2266 2361 4.52210685418043e-06 908 1.78964464232397 1.68132890410606 1 6.90297387833702 2460 1104 3779 1965 2916 2361 1882 2414 908 2074 3063 2297 M15677 GO_GANGLION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLION_DEVELOPMENT.html The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. 9/27 Gene Ontology BP GO:0061548 3.75457463917071e-06 7.10660010178133e-06 1575 2369.81818181818 2361 3.75458098275962e-07 1570 1.61309712274758 -0.922121034616969 -1 7.70897627697169 1572 1570 4438 2595 2395 2087 1682 2581 2515 2361 2272 2298 M16769 GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of tight junction assembly. 13/24 Gene Ontology BP GO:2000810 0.00263316039449152 0.00331951227576002 2170 2340.63636363636 2361 0.000239665208347023 1493 1.54487960370497 1.22867600620039 1 3.55489903409865 2169 2396 1971 2361 3477 2366 1493 2684 1843 2321 2666 2299 M10400 GO_PIGMENT_GRANULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_LOCALIZATION.html Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. 16/29 Gene Ontology BP GO:0051875 2.73463376360917e-05 4.3933925828503e-05 4180 2668.36363636364 2362 2.48606159647098e-06 686 1.72836854390529 -1.15180390432986 -1 6.99057624587157 4179 2362 2250 1950 2788 1977 4125 3196 686 2190 3649 2300 M12871 GO_PROTEIN_LOCALIZATION_TO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMATIN.html Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. 12/19 Gene Ontology BP GO:0071168 0.000212536618619902 0.000301223296780282 2070 2751.18181818182 2364 1.93233776400205e-05 1045 2.33533417513444 -2.33533417513444 -1 7.63304699232155 2066 4303 2364 3822 4295 1472 2064 1045 3864 3400 1568 2301 M13835 GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. 34/76 Gene Ontology BP GO:0030433 9.24427691958311e-08 3.07314675792064e-07 595 1952.18181818182 2365 8.40388846183864e-09 29 0.892255310359597 -0.897857063065995 -1 5.39386966928366 594 2818 3215 2793 2365 29 498 1023 3878 4035 226 2302 M15990 GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. 62/167 Gene Ontology BP GO:0072593 3.25731848156927e-09 3.84357595519315e-08 4515 2375.36363636364 2365 2.96119862399278e-10 116 1.62369144425129 -1.59600114717799 -1 11.1763317671062 4511 789 1342 1564 116 2471 4239 3486 2365 1394 3852 2303 M12548 GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 6/13 Gene Ontology BP GO:0043650 3.31744070062718e-06 6.35404665995445e-06 3470 2301.27272727273 2367 3.31744565307335e-07 54 2.59270145352329 -2.2172379992857 -1 12.5074896279817 3466 442 3929 54 2367 4631 4006 1827 168 1078 3346 2304 M16109 GO_FEMALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. 11/23 Gene Ontology BP GO:0030540 1.8329824627514e-07 5.2827669612382e-07 4130 2465.36363636364 2367 1.66634783224611e-08 205 3.07713549531039 -2.01134696562076 -1 17.9298836598529 4127 2367 988 696 1535 4078 4323 3028 205 1456 4316 2305 M13948 GO_OOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. 18/71 Gene Ontology BP GO:0009994 7.48318427806052e-05 0.00011197043056086 4435 2683.27272727273 2368 6.8031262061448e-06 874 2.45861365631112 -3.28593717873281 -1 9.01685511707386 4431 3794 1698 2059 3757 3599 3647 874 1355 1934 2368 2306 M15238 GO_COENZYME_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 10/22 Gene Ontology BP GO:0009109 1.48104994153716e-05 2.48968677717488e-05 4265 2433.45454545455 2368 1.34641810193297e-06 942 1.4166407796429 -0.853321379670032 -1 6.05411311358784 4264 2368 2102 1941 2672 1840 1918 3695 942 2491 2535 2307 M10918 GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL.html Any virus-mediated process that modulates the levels of viral proteins in a cell. 5/18 Gene Ontology BP GO:0046719 8.53433367898682e-06 1.49923992703503e-05 1690 2511.09090909091 2369 8.53436645484708e-07 1485 1.07892904002783 -1.07892904002783 -1 4.8314880140512 1689 2298 3659 3328 2583 1485 2369 3098 3062 2261 1790 2308 M14329 GO_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE.html Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. 505/1745 Gene Ontology BP GO:0006955 1.30926616916487e-08 8.09443784744674e-08 2040 2400.63636363636 2369 1.30926617687867e-09 150 1.74388392276071 2.03591125452426 1 11.4800558953887 2036 1769 4225 2145 626 4535 2476 2832 2369 150 3244 2309 M14846 GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. 11/22 Gene Ontology BP GO:0032682 0.00042467143855623 0.000582668288775584 1625 2345.18181818182 2370 3.86139487358319e-05 1064 1.26416679243742 1.26416679243742 1 3.79569412907511 1623 3059 2370 3531 3237 1554 1064 1381 3335 3326 1317 2310 M11626 GO_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 444/1387 Gene Ontology BP GO:0050776 3.04170447857038e-08 1.3850847965508e-07 2445 2232.27272727273 2371 2.76518592784071e-09 814 1.73964564620599 2.10966403872419 1 11.0754292848521 2445 1711 814 2371 903 4075 2741 2518 2134 924 3919 2311 M10471 GO_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 26/70 Gene Ontology BP GO:0051602 0.002074176729779 0.0026428108003194 1405 2245.45454545455 2372 0.00018873953313297 981 2.06582870087792 2.49460336299468 1 4.94350768115982 1401 2852 981 2921 3441 2372 1921 2432 3061 1574 1744 2312 M13775 GO_VOCALIZATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOCALIZATION_BEHAVIOR.html The behavior in which an organism produces sounds by a mechanism involving its respiratory system. 7/36 Gene Ontology BP GO:0071625 3.37115308059421e-06 6.43596371430878e-06 4345 2297.45454545455 2372 3.37115819470803e-07 199 2.14074779307963 -1.32987314726819 -1 10.3161582306279 4342 242 4132 526 2372 3968 4190 964 199 1314 3023 2313 M16580 GO_BONE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. 9/37 Gene Ontology BP GO:0070977 0.00345267471490768 0.00431398511876113 1645 2733.45454545455 2373 0.000345805090793329 1619 1.83846963491802 1.83846963491802 1 4.03625886041689 1643 3730 4585 3670 3920 1621 1905 1619 3028 2373 1974 2314 M12607 GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. 14/34 Gene Ontology BP GO:0002292 2.35397623440151e-06 4.67672728126923e-06 3125 2573.81818181818 2374 2.13998068466765e-07 1900 1.60877007747569 -1.44283399513004 -1 7.9596696261826 3122 1959 2022 2982 2263 2374 3146 3780 2141 1900 2623 2315 M14368 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex assembly. 115/268 Gene Ontology BP GO:0031334 1.22299763661579e-08 7.68916604102299e-08 3510 2467.36363636364 2374 1.11181603946776e-09 563 1.60305019647378 -1.06241427499305 -1 10.5861364744531 3507 1938 2134 741 563 3213 3778 2374 1505 3002 4386 2316 M14513 GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organonitrogen compound. 923/2218 Gene Ontology BP GO:1901564 5.01054167040511e-08 1.96818485411937e-07 2670 2280.09090909091 2375 5.01054178337999e-09 500 1.45551594519331 -1.13251964992386 -1 9.06035850008428 2668 1710 4246 2385 1113 500 2375 3408 2231 2594 1851 2317 M16030 GO_MATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING_BEHAVIOR.html The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. 9/27 Gene Ontology BP GO:0007617 3.28062430179278e-07 8.5572688950696e-07 2545 2267.54545454545 2376 3.28062478610519e-08 351 1.99318883736972 1.96396838011245 1 11.2263651212469 2541 1178 4496 1470 1728 2376 2617 3556 351 1145 3485 2318 M11583 GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 21/49 Gene Ontology BP GO:0051023 0.000217609343664196 0.000307848928285454 1795 2477.72727272727 2377 1.97846246465378e-05 1794 1.50398424455545 -1.33852471140766 -1 4.90258534584886 1794 2232 2004 2798 3154 1798 3082 3208 2981 1827 2377 2319 M16592 GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species. 9/27 Gene Ontology BP GO:0044705 3.28062430179278e-07 8.5572688950696e-07 2545 2278.09090909091 2377 3.28062478610519e-08 352 1.99318883736972 1.96396838011245 1 11.2263651212469 2542 1179 4588 1471 1729 2377 2618 3569 352 1148 3486 2320 M12316 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. 72/212 Gene Ontology BP GO:1902107 3.8256307530405e-06 7.22930548895688e-06 2275 2310.09090909091 2378 3.47785218684933e-07 1089 1.63751197267527 -1.4932847823407 -1 7.81435361853778 2273 2306 1523 2702 2378 1599 2889 3046 3043 1089 2563 2321 M14274 GO_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_SECRETION.html The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 23/87 Gene Ontology BP GO:0050663 5.62186093703777e-05 8.55813125595618e-05 1880 2418.81818181818 2379 5.11091327520432e-06 1096 1.9393269835966 2.18490296389311 1 7.32252152995255 1878 3771 1690 2836 2942 2524 2182 1096 3257 2052 2379 2322 M11683 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. 2/12 Gene Ontology BP GO:1902572 0.00213056303436016 0.00270945060765112 2580 2621.6 2381.5 0.000236953690116172 1493 1.48438077930719 -1.48438077930719 -1 3.53720638384656 2013 2578 3789 NA 3471 1493 1940 2185 4190 2580 1977 2323 M13174 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. 2/12 Gene Ontology BP GO:1900004 0.00213056303436016 0.00270945060765112 2015 2646.8 2383 0.000236953690116172 1494 1.48438077930719 -1.48438077930719 -1 3.53720638384656 2014 2579 4028 NA 3472 1494 1941 2187 4191 2584 1978 2324 M11051 GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type peptidase activity. 2/15 Gene Ontology BP GO:1902571 0.00213056303436016 0.00270945060765112 2580 2610 2383.5 0.000236953690116172 1492 1.48438077930719 -1.48438077930719 -1 3.53720638384656 2012 2577 3676 NA 3470 1492 1939 2190 4189 2579 1976 2325 M15052 GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. 2/15 Gene Ontology BP GO:1900003 0.00213056303436016 0.00270945060765112 2015 2679 2384.5 0.000236953690116172 1495 1.48438077930719 -1.48438077930719 -1 3.53720638384656 2015 2580 4339 NA 3473 1495 1942 2189 4192 2586 1979 2326 M10235 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that activates or increases the rate of gene expression. 48/111 Gene Ontology BP GO:0045815 2.4970596807923e-06 4.92516911551344e-06 2530 2315.81818181818 2385 2.27005683184298e-07 1174 2.32619225356177 -1.70712521421269 -1 11.4607013271148 2528 2972 1618 2274 2276 1666 2507 3389 1174 2385 2685 2327 M11910 GO_FOREBRAIN_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_REGIONALIZATION.html The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. 2/33 Gene Ontology BP GO:0021871 2.05011165106408e-06 4.12957414138417e-06 2170 2188.1 2385.5 2.27790391005303e-07 31 3.33233234620462 -3.33233234620462 -1 16.6544439893173 2167 3044 3821 NA 3859 2190 2857 376 31 2581 955 2328 M14388 GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. 10/28 Gene Ontology BP GO:0014874 3.58244690480465e-08 1.55306264976732e-07 4395 2818.54545454545 2387 3.25676996649153e-09 965 1.62414991342497 -1.37518181421136 -1 10.2651790193645 4395 2371 1958 2082 965 3792 4356 2477 2387 1875 4346 2329 M13385 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of activation. 163/554 Gene Ontology BP GO:0050867 4.67508543176582e-08 1.87934386663972e-07 3265 2315.36363636364 2388 4.25007775555746e-09 835 1.63117258014241 -1.2538436823733 -1 10.1841668365124 3261 1207 985 1460 1052 3872 3382 2631 2388 835 4396 2330 M16489 GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. 10/25 Gene Ontology BP GO:0072525 5.1319280139426e-05 7.86566585732251e-05 1835 2265.36363636364 2391 4.66549793641587e-06 985 1.10686097389478 -1.12817650865931 -1 4.21694113209718 1834 1413 2391 2723 2923 985 1035 3919 3122 2503 2071 2331 M11219 GO_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. 854/2124 Gene Ontology BP GO:0044281 1.62501866181999e-08 9.07937622963925e-08 2875 1907.36363636364 2392 1.62501867370307e-09 2 1.45062979564941 -1.20145129742159 -1 9.48240046641455 2874 2 3711 2462 702 382 2655 3082 2392 1087 1632 2332 M11958 GO_MITOTIC_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_ARREST.html The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). 11/18 Gene Ontology BP GO:0071850 1.3384527928363e-08 8.17688989097228e-08 3135 2323.45454545455 2392 1.21677527361752e-09 595 1.18108348044564 -1.32412788417703 -1 7.7702930190052 3134 1622 2342 2392 595 1793 3404 2877 3156 2656 1587 2333 M15035 GO_NEUROTRANSMITTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 9/41 Gene Ontology BP GO:0042133 1.1842286586581e-08 7.55763097835705e-08 2750 2175.72727272727 2392 1.18422866496888e-09 585 2.78150411648517 3.02333838832884 1 18.3876951305888 2749 1818 4336 606 585 3443 2517 2392 661 1142 3684 2334 M16367 GO_PHOSPHOLIPID_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_EFFLUX.html The directed movement of a phospholipid out of a cell or organelle. 5/18 Gene Ontology BP GO:0033700 8.38531287448882e-06 1.47641288116237e-05 2395 2405.45454545455 2393 8.38534451571927e-07 949 2.82300380464947 2.82300380464947 1 12.6589869690851 2393 2454 4553 2735 2579 3126 2053 1495 949 2293 1830 2335 M16099 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 8/30 Gene Ontology BP GO:0055015 8.85227728558321e-06 1.54787816346649e-05 2395 2079.27272727273 2394 8.85231254904683e-07 176 3.83184080751445 4.69009700783082 1 17.1098198815799 2394 3433 4507 1176 2588 2399 862 728 176 2152 2457 2336 M16127 GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 9/20 Gene Ontology BP GO:0009226 1.51187583826284e-05 2.53508108235984e-05 2140 2515.27272727273 2396 1.51188612431981e-06 1335 0.944085278392159 -0.923592161497593 -1 4.02773728665871 2139 2482 4514 2396 2701 1713 3302 1788 2930 2368 1335 2337 M13291 GO_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 22/76 Gene Ontology BP GO:0042446 2.26401026226699e-06 4.51731828435997e-06 3775 2705.36363636364 2397 2.0581932655939e-07 1710 2.0557890377405 -2.04876850606022 -1 10.2001153483287 3772 3036 1891 2358 2251 2827 4199 1905 1710 2397 3413 2338 M14334 GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 12/32 Gene Ontology BP GO:0071236 0.000706277124627514 0.000942582549481331 2260 2435.54545454545 2397 6.42276333004146e-05 1465 1.45880695079631 1.57228890614257 1 4.09722699956814 2257 2397 2408 1465 3306 3642 2254 2578 2086 2809 1589 2339 M14795 GO_PHOSPHOLIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORT.html The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. 26/68 Gene Ontology BP GO:0015914 3.99913594571232e-05 6.24764071195905e-05 2875 2500.54545454545 2397 3.63564422128943e-06 1436 1.90909918632293 2.49243935833533 1 7.45057280922468 2397 2263 1804 2114 2871 4293 2872 1436 2059 2790 2607 2340 M16359 GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosyl compound. 63/135 Gene Ontology BP GO:1901659 4.20036291741718e-06 7.86065498813704e-06 1110 2316.54545454545 2397 3.81851903364199e-07 971 0.972855848908142 -0.919872210388025 -1 4.6097177675577 1107 1291 3211 2978 2397 971 1893 2569 3208 3887 1970 2341 M10815 GO_PROTEIN_LOCALIZATION_TO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CILIUM.html A process in which a protein is transported to, or maintained in, a location within a cilium. 14/32 Gene Ontology BP GO:0061512 0.000256342889490566 0.00035946844938227 2360 2645.18181818182 2398 2.3306614846182e-05 1053 0.790277873771882 -0.790277873771882 -1 2.52670678781828 2360 2101 3037 3278 3181 1053 2280 2398 3935 3967 1507 2342 M16499 GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. 8/16 Gene Ontology BP GO:0002903 7.9993015769288e-06 1.41704529651585e-05 1490 2341 2398 7.99933037204626e-07 1143 1.47857758546977 1.57374808414522 1 6.65473952598803 1490 2290 4571 2857 2560 2398 2459 1143 2630 1534 1819 2343 M14330 GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of T cell mediated immunity. 39/118 Gene Ontology BP GO:0002709 0.00595202444352063 0.00726287765867708 2180 2719.54545454545 2401 0.00054256260900392 1727 1.47615793582673 -1.4542753924411 -1 2.93083011809823 2177 3631 2401 3362 3685 1940 3474 1727 3372 1997 2149 2344 M14623 GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of monocyte differentiation. 5/19 Gene Ontology BP GO:0045655 1.97747388301126e-06 4.01420448786341e-06 3560 2755 2401 1.97747564269479e-07 958 1.43740135230351 1.41318178823148 1 7.20031263153881 3557 1189 4262 1730 2238 4457 4376 2401 958 1507 3630 2345 M14854 GO_PHARYNGEAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHARYNGEAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. 8/36 Gene Ontology BP GO:0060037 3.89530242028701e-06 7.35198745422462e-06 3325 2640.81818181818 2401 3.89530924832527e-07 971 1.5143162699783 -1.66251300993855 -1 7.21617974407323 3321 1260 4305 2242 2401 3056 4231 2036 3012 971 2214 2346 M13770 GO_OXIDATION_REDUCTION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATION_REDUCTION_PROCESS.html A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. 435/1065 Gene Ontology BP GO:0055114 5.08356962240627e-08 1.99013606718653e-07 2405 2163.09090909091 2402 4.62142703624818e-09 471 1.39049479023441 -1.13456904112154 -1 8.6493946557094 2402 2343 2661 3252 1087 471 2702 2889 2607 2206 1174 2347 M15824 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. 14/35 Gene Ontology BP GO:2000352 5.83211030747179e-08 2.1950953983024e-07 3155 2714.36363636364 2402 5.30191860188969e-09 1087 1.35692004329399 -1.29530255116871 -1 8.38692641819213 3154 1087 1846 2402 1138 4109 2113 4371 3320 1909 4409 2348 M10477 GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of ERBB signaling pathway. 53/115 Gene Ontology BP GO:1901184 4.81973956791947e-06 8.89783332558653e-06 1855 2240.27272727273 2404 4.38159102453868e-07 1117 1.5096563131684 1.60196345977998 1 7.07783026177082 1853 2971 2119 3139 2431 2481 1117 1543 2789 2404 1796 2349 M10485 GO_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLERANCE_INDUCTION.html A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. 5/14 Gene Ontology BP GO:0002507 2.44137135558265e-05 3.95508974318571e-05 3005 2448.90909090909 2405 2.4413981773208e-06 990 1.34632755827681 -0.990462304195321 -1 5.50241225710161 3002 990 3597 2003 2785 3864 2405 1463 1799 2259 2771 2350 M11784 GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 80/213 Gene Ontology BP GO:0032869 4.85031002770058e-08 1.92314171294738e-07 3150 2675.18181818182 2406 4.40937284966793e-09 1072 1.59236552147245 1.68024986015856 1 9.92708764800169 3149 1516 1866 1526 1072 4080 3192 4010 2197 2406 4413 2351 M12277 GO_ALDITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 10/26 Gene Ontology BP GO:0019400 4.00191126618064e-07 1.01037922832391e-06 3160 2438.36363636364 2407 3.63810181286248e-08 1390 1.67394762269609 -1.2525226743168 -1 9.31617277701643 3156 2893 2098 2466 1767 2352 2920 2407 2179 3194 1390 2352 M12588 GO_REGULATION_OF_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESODERM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of mesoderm development. 10/28 Gene Ontology BP GO:2000380 3.6849949005332e-06 6.989146782343e-06 3165 2343.63636363636 2408 3.35000097536872e-07 784 3.09836088249386 3.55727749070873 1 14.8278545385253 3165 3279 1555 1152 2371 3730 2408 1147 784 2475 3714 2353 M12647 GO_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BACTERIUM.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. 277/948 Gene Ontology BP GO:0009617 1.52213674129884e-12 3.99281406206244e-11 2955 2459.54545454545 2408 1.38376067390899e-13 163 1.9103827473584 -1.81350007043333 -1 18.4403622111147 2951 1883 163 1986 1083 4189 3090 4486 2408 501 4315 2354 M15655 GO_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_LOCALIZATION.html Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. 31/54 Gene Ontology BP GO:0051646 1.1045685102684e-06 2.42597520963868e-06 2130 2592.36363636364 2408 1.00415369531526e-07 1475 1.49654191678686 1.66571975988762 1 7.80039448516922 2126 3514 2176 3041 2044 2981 1849 4442 2460 2408 1475 2355 M10893 GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. 4/48 Gene Ontology BP GO:0042738 0.00591188082180035 0.00722148451871061 1305 2529.63636363636 2409 0.000592766761338177 1092 1.69867391400576 1.69867391400576 1 3.37653736915409 1301 2809 3653 2409 3856 1604 1092 2192 3527 3108 2275 2356 M10116 GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of hepatocyte proliferation. 6/16 Gene Ontology BP GO:2000345 4.11127751427334e-06 7.7032532279141e-06 3710 2185.36363636364 2410 4.11128512046442e-07 39 2.36181397441224 -1.46559243725043 -1 11.2103272202925 3706 729 3536 507 2410 4093 4292 501 39 1072 3154 2357 M16044 GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 9/17 Gene Ontology BP GO:0060547 5.35421896981023e-05 8.16676697661921e-05 2490 2453.36363636364 2410 5.35434797865844e-06 1111 1.26030091254778 -1.26345171054845 -1 4.78243341687372 2487 1628 4499 2410 2950 1433 1936 2833 3333 2367 1111 2358 M10273 GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON.html A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. 17/38 Gene Ontology BP GO:0044380 4.52527620035683e-06 8.41107181675611e-06 950 1982.45454545455 2411 4.11389591692921e-07 172 0.995318809322361 -0.995318809322361 -1 4.688998595306 947 3344 2917 3208 2411 172 735 702 3679 3349 343 2359 M14783 GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. 11/31 Gene Ontology BP GO:0034394 0.000303763528384457 0.00042328153129923 1240 2306.90909090909 2411 2.76186798581624e-05 933 1.43541591793646 1.78151418871062 1 4.49480594375852 1238 2959 2411 1279 3394 2001 1520 3748 3226 2667 933 2360 M14285 GO_REGULATION_OF_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACROSOME_REACTION.html Any process that modulates the frequency, rate or extent of the acrosome reaction. 3/28 Gene Ontology BP GO:0060046 6.31882285206976e-05 9.54090878119022e-05 2880 2404.90909090909 2412 6.31900253311055e-06 98 2.62393854586934 -1.48438077930719 -1 9.79249063394639 2877 2412 4218 1235 2975 4089 3759 1513 98 1760 1518 2361 M14167 GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 8/18 Gene Ontology BP GO:0060391 4.20890433212711e-06 7.87338706067589e-06 2910 2671.09090909091 2413 4.20891230384241e-07 1875 1.84416974817088 -1.50465349684975 -1 8.73709264016075 2907 2409 4196 1875 2421 3493 2413 2074 2258 2140 3196 2362 M15735 GO_COLLECTING_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLECTING_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. 5/27 Gene Ontology BP GO:0072044 8.1870780099891e-06 1.44699669586522e-05 3380 2394 2413 8.18710817285635e-07 209 2.9702483800453 -2.0650486569386 -1 13.3433632925002 3378 1578 4450 1023 2570 2413 3527 1713 209 2291 3182 2363 M14918 GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. 8/34 Gene Ontology BP GO:0022400 4.67867876786431e-06 8.65462371282629e-06 2480 2487.09090909091 2415 4.67868861840926e-07 1460 1.17738338013106 1.35719859539585 1 5.53316555700341 2477 1629 4317 2078 2441 2415 1460 4140 1649 2144 2608 2364 M13565 GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. 20/52 Gene Ontology BP GO:0002726 0.0111234495881514 0.0133005862574779 2170 2643.54545454545 2416 0.0010163720334828 1775 1.40648739365656 -1.22257611731617 -1 2.44944502456947 1897 3087 2416 3056 3642 1775 2931 2348 3592 2167 2168 2365 M11008 GO_LYMPHOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. 35/71 Gene Ontology BP GO:0002260 2.27367363471618e-07 6.31002192826494e-07 2360 2356.54545454545 2417 2.0669762451797e-08 1224 1.25079037845043 1.6457449807428 1 7.19851955905443 2358 1224 2421 1897 1604 3537 2417 2050 2665 3140 2609 2366 M14819 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. 29/70 Gene Ontology BP GO:1903201 3.98062344146977e-07 1.00664676681613e-06 2125 2419.09090909091 2418 3.61874923792157e-08 1118 1.28680870203713 1.68153090031189 1 7.16351323847629 2123 3175 2692 3187 1764 2418 1680 1118 3314 3059 2080 2367 M10803 GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. 75/152 Gene Ontology BP GO:0034250 2.57779784328141e-06 5.06934154441152e-06 3685 2822.27272727273 2419 2.3434553306908e-07 1984 1.68014957042221 -1.04851378356512 -1 8.25823077201146 3684 2170 2175 2419 2284 2787 4583 2525 1984 2390 4044 2368 M10707 GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. 20/53 Gene Ontology BP GO:0034162 1.57693743782529e-05 2.63750739330793e-05 1895 2141.36363636364 2420 1.43358976478595e-06 936 1.22791488599585 -1.22040631552071 -1 5.21902843062341 1895 2003 2599 2420 2691 936 2603 1239 3201 2631 1337 2369 M11273 GO_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_PROCESS.html A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. 11/21 Gene Ontology BP GO:0003016 4.60143995113559e-06 8.52873680364174e-06 2640 2454.90909090909 2420 4.18313597760741e-07 1280 1.96310419456778 1.91976306743182 1 9.23729157289336 2773 2636 1280 1690 2420 4161 3205 2636 2337 2007 1859 2370 M11095 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. 5/24 Gene Ontology BP GO:0048172 0.000147332400855662 0.000212376385337734 2755 2490.72727272727 2421 1.47342169843578e-05 1271 1.24834346348581 -1.26899629093585 -1 4.25609762583612 2753 1934 3688 2965 3107 2278 2134 1271 3352 1495 2421 2371 M16000 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 292/975 Gene Ontology BP GO:0050778 5.98649184164028e-08 2.23255274062135e-07 4255 2666.27272727273 2421 5.44226545867334e-09 1151 1.68519329352515 -1.35537451847149 -1 10.4044409623928 4251 2031 1682 2535 1151 2421 4011 3387 2339 2064 3457 2372 M15962 GO_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_MEDIATED_ENDOCYTOSIS.html An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. 27/51 Gene Ontology BP GO:0072583 7.87681684322774e-08 2.71285150781197e-07 2475 2235.27272727273 2422 7.16074284113368e-09 246 1.97241574436098 2.33983180335531 1 12.022822535536 2471 2422 1918 1726 1263 3882 3242 2095 246 2887 2436 2373 M10317 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 20/52 Gene Ontology BP GO:0050732 1.77998388323182e-06 3.67236485781654e-06 2525 2446.18181818182 2424 1.61816847580835e-07 1471 1.29339090007167 -1.28330450086462 -1 6.52533492061385 2523 2821 2424 2415 2173 1562 3223 1471 3204 3156 1936 2374 M11662 GO_TRANSLATIONAL_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_TERMINATION.html The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). 62/100 Gene Ontology BP GO:0006415 0.00191357940572418 0.00244893858345572 350 2541.72727272727 2426 0.000174113262149819 350 0.591430779570216 -0.590231041723962 -1 1.43345331019735 350 2681 3483 2426 3432 1135 1934 2182 3916 4261 2159 2375 M11561 GO_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the meiotic cell cycle. 24/61 Gene Ontology BP GO:0051445 2.04710812578769e-08 1.04975088286426e-07 3375 2470.72727272727 2427 1.86100740439647e-09 761 1.53452436203538 -1.73284990312881 -1 9.94101552761298 3374 3003 1910 1569 761 3797 2427 1650 1472 2616 4599 2376 M14227 GO_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of B cell activation. 56/269 Gene Ontology BP GO:0050864 7.96619856558912e-08 2.73370731264082e-07 4545 2658 2427 7.24199895822283e-09 1268 1.59084562044106 -1.2634498940891 -1 9.69205753852139 4545 1292 1951 1895 1268 2427 4524 3706 2481 1489 3660 2377 M10240 GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that activates or increases the frequency, rate or extent of protein binding. 58/132 Gene Ontology BP GO:0032092 3.52753375296032e-08 1.53211779373197e-07 1770 2442.18181818182 2428 3.20684891774697e-09 963 1.36629787423686 1.69596871347183 1 8.64294533891301 1769 2877 2236 3465 963 3296 2152 1998 2812 2428 2868 2378 M11143 GO_POSITIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COAGULATION.html Any process that activates or increases the frequency, rate or extent of coagulation. 11/46 Gene Ontology BP GO:0050820 0.025854578000807 0.029883695707679 1410 2405 2428 0.00237850165199125 1408 2.08918708015163 2.08918708015163 1 2.95660009724215 1408 3092 1838 2216 3821 2084 1464 2500 2953 2651 2428 2379 M12721 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. 16/58 Gene Ontology BP GO:0002686 5.7856365741085e-08 2.18041482253131e-07 4340 2664.18181818182 2428 5.25966975114655e-09 914 1.6873842560523 -1.40018342790896 -1 10.4340426559089 4340 1616 1123 2428 1137 4166 3616 3781 1878 914 4307 2380 M14494 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. 19/67 Gene Ontology BP GO:0002833 0.000363427286258146 0.000502948700475879 1990 2326.27272727273 2428 3.30443032939937e-05 966 1.37278346454779 -1.60073482655965 -1 4.203243303958 1987 3369 2428 3404 3273 1006 1637 1209 3284 3026 966 2381 M12468 GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 8/24 Gene Ontology BP GO:0010758 4.3608322369475e-06 8.12941850333043e-06 2990 2342.36363636364 2429 4.36084079455715e-07 967 1.8386537085236 -1.12057308954882 -1 8.68723922871939 2869 1875 3913 1282 2429 3804 2989 1426 1222 967 2990 2382 M15087 GO_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 112/329 Gene Ontology BP GO:0016042 1.38451147877599e-08 8.32189868277674e-08 2665 2265.54545454545 2432 1.25864680680822e-09 608 1.51838466391144 -1.33987315377561 -1 9.97862163950399 2661 1717 1564 2961 608 1745 3757 2809 2671 1996 2432 2383 M11735 GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. 6/17 Gene Ontology BP GO:0060389 7.14071497179999e-06 1.27565754575096e-05 2550 2098.54545454545 2433 7.1407379173184e-07 215 1.97418897780832 2.54689380289478 1 8.96902873496152 2546 1822 3797 1780 3173 3598 2433 532 215 2528 660 2384 M13685 GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of epidermis development. 18/47 Gene Ontology BP GO:0045684 7.55943665827378e-07 1.73754774279035e-06 4535 2844.45454545455 2433 6.87221750525344e-08 1543 2.06190502850981 2.38608488081978 1 11.024655934975 4534 1806 1543 2157 1952 3090 3946 4118 2433 1932 3778 2385 M11666 GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS.html The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 11/36 Gene Ontology BP GO:0003203 5.15040596552192e-07 1.24678492689876e-06 4405 2795.72727272727 2434 4.68218833752779e-08 1789 1.24259711496578 0.973827430041724 1 6.81022017133849 4405 2243 1789 2282 1845 4229 2791 2434 3484 2011 3240 2386 M10889 GO_COFACTOR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORT.html The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. 13/27 Gene Ontology BP GO:0051181 0.000114365042009376 0.000166875201146931 2780 2598.45454545455 2435 1.03973625097284e-05 1207 1.63301934030893 -1.61288138837293 -1 5.72634312030276 2780 3696 2435 4596 3051 1500 2261 1207 3247 2297 1513 2387 M11562 GO_DNA_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEALKYLATION.html The removal of an alkyl group from one or more nucleotides within an DNA molecule. 7/20 Gene Ontology BP GO:0035510 0.00565225046132989 0.00691525662502099 2445 2614.27272727273 2435 0.000566667870868856 1473 0.798161549064038 -0.885102049219768 -1 1.60048711380057 2442 2072 3770 2435 3803 1473 2141 2127 3286 3551 1657 2388 M13369 GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 10/20 Gene Ontology BP GO:0050857 0.00404454228327594 0.00501704777484643 2435 2674 2435 0.000368363370775644 1636 1.55037345595713 1.6694759114617 1 3.30939517791105 2435 3325 2039 3634 3602 3203 2208 1636 3692 1868 1772 2389 M11916 GO_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CHEMOTAXIS.html The movement of a leukocyte in response to an external stimulus. 52/167 Gene Ontology BP GO:0030595 3.34409937002019e-06 6.39746739802378e-06 1960 2426 2436 3.04009495746645e-07 660 2.31716862700007 2.40814150616936 1 11.1719258278229 1958 2942 660 2239 2347 3718 2715 3368 2436 1256 3047 2390 M15296 GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 13/51 Gene Ontology BP GO:0035249 0.000500461986087262 0.000681021395487444 1665 2582.63636363636 2436 4.55068971647393e-05 1225 1.45519770171765 1.45519770171765 1 4.27776713733763 1664 4047 2559 4571 3255 2436 1242 1225 3366 2315 1729 2391 M10177 GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. 14/37 Gene Ontology BP GO:1904030 2.30342420013468e-06 4.58313238782894e-06 4055 2719.45454545455 2437 2.09402419258972e-07 1259 1.68073725087747 -0.780846036965248 -1 8.32943737854046 4054 2391 1779 2545 2257 3725 4363 1537 1259 2437 3567 2392 M16456 GO_EMBRYONIC_PLACENTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_MORPHOGENESIS.html The process in which the embryonic placenta is generated and organized. 13/31 Gene Ontology BP GO:0060669 1.20272349439425e-07 3.79880624794047e-07 3960 2741.36363636364 2438 1.0933850546784e-08 1012 2.02327480392276 1.55077095070896 1 12.0582117274495 3956 2438 1713 2203 1391 4563 4017 2972 1012 1789 4101 2393 M11732 GO_ANATOMICAL_STRUCTURE_ARRANGEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_ARRANGEMENT.html The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 14/39 Gene Ontology BP GO:0048532 0.00022803344368074 0.000321615819869281 2965 2482 2439 2.07324621031422e-05 1065 2.28477969435825 2.82575205181803 1 7.4074732876881 2964 3372 1482 1459 3302 3888 3195 1065 1709 2439 2427 2394 M12014 GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. 14/25 Gene Ontology BP GO:0046621 7.73106681331842e-07 1.76998733798015e-06 3305 2346.54545454545 2440 7.02824502737309e-08 149 2.55611019826122 3.45797805406843 1 13.6480259394427 3303 2061 1616 578 1959 4377 3501 2514 149 2440 3314 2395 M16193 GO_PROTEIN_TETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TETRAMERIZATION.html The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. 78/176 Gene Ontology BP GO:0051262 2.65027489243137e-07 7.18763219950866e-07 2055 2334.54545454545 2441 2.40934110154745e-08 1286 1.4984798547489 -1.27070409507801 -1 8.54534959482237 2054 2969 2118 2811 1646 1286 2441 2821 2517 2593 2424 2396 M16892 GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. 8/20 Gene Ontology BP GO:0042789 0.00265427083679347 0.00334521701824976 1750 2733.90909090909 2441 0.000265744649565178 1362 1.28029935544859 1.28029935544859 1 2.94209607401431 1747 2109 4633 2827 3488 2284 1362 2441 3847 3665 1670 2397 M12821 GO_REGULATION_OF_STEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of steroid hormone secretion. 7/30 Gene Ontology BP GO:2000831 0.000191961662469642 0.000273734029129775 3245 2543.09090909091 2442 1.91978246661849e-05 1044 2.08724543521003 -2.55311643358102 -1 6.9026903808713 3243 2111 3965 2442 3147 2645 3816 1044 1443 1964 2154 2398 M15867 GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 11/28 Gene Ontology BP GO:0048261 2.45963313882399e-06 4.86167588912719e-06 2710 2432.72727272727 2444 2.2360326261229e-07 1172 1.03615648737949 -1.01040617044439 -1 5.11036339291777 2706 1172 2619 2444 2271 1972 2870 2408 2985 3330 1983 2399 M15041 GO_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXPLORATION_BEHAVIOR.html The specific behavior of an organism in response to a novel environment or stimulus. 14/41 Gene Ontology BP GO:0035640 4.15005930651472e-05 6.45302255865635e-05 2820 2258.90909090909 2445 3.77285235900971e-06 420 1.71213609400403 2.12593306676342 1 6.65956680960402 2818 420 2044 1340 2899 4275 4410 784 612 2445 2801 2400 M11126 GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. 3/20 Gene Ontology BP GO:2000311 4.74671147988289e-06 8.7769738753868e-06 3305 2034.45454545455 2446 4.74672161898481e-07 5 2.30107282953576 2.34134167188661 1 10.8009719749469 3301 249 3696 281 2446 3176 2798 1191 5 891 4345 2401 M11335 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. 19/45 Gene Ontology BP GO:0002475 0.0109674416497177 0.0131241833968142 1980 2549.90909090909 2446 0.00100204556450607 1605 1.53522703987336 -0.971857467965033 -1 2.68191282485969 1978 3119 2303 2229 3640 1605 2446 3240 2423 2557 2509 2402 M15618 GO_DORSAL_VENTRAL_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 14/35 Gene Ontology BP GO:0009950 0.000490739758990091 0.000668771558846784 1745 2555.81818181818 2446 4.46226599389772e-05 1567 1.40511816310274 1.25003626251046 1 4.14083283165175 1742 3185 2286 1617 3253 2337 1567 3516 3119 2446 3046 2403 M10378 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 7/17 Gene Ontology BP GO:0090141 0.00484677097113864 0.00596753052744543 1455 2598.27272727273 2449 0.0004857374569653 1455 1.00301225735576 -1.00301225735576 -1 2.07085752772269 1455 2449 3575 3263 3935 1512 1497 2421 3313 3540 1621 2404 M16776 GO_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ASSEMBLY.html Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 14/40 Gene Ontology BP GO:0030032 2.01617775770412e-05 3.31249587014163e-05 1415 2315.18181818182 2449 1.83290566826369e-06 728 1.00596624691571 -1.00596624691571 -1 4.18326603695256 1412 3010 2900 3700 2731 728 1824 1897 3632 2449 1184 2405 M11253 GO_PHOTOTRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION.html The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. 15/64 Gene Ontology BP GO:0007602 5.39348598276566e-06 9.90583679508741e-06 3795 2495.81818181818 2450 4.90318109581626e-07 804 1.89784917909681 -1.59198333819238 -1 8.81571567629708 3792 964 1321 1725 2450 4417 2973 3244 1354 804 4410 2406 M14326 GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS.html The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. 6/16 Gene Ontology BP GO:0060670 2.86956515729233e-07 7.64833009489568e-07 3035 2522.09090909091 2450 2.86956552784058e-08 1134 1.83706057629141 1.45347452718905 1 10.4301573557367 3033 2450 4224 2081 1700 3138 2312 2488 1134 1732 3451 2407 M10425 GO_B_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 16/28 Gene Ontology BP GO:0001782 0.0168921230271152 0.019885934892215 2545 2689.54545454545 2451 0.0015475669413185 1977 1.74410573179243 2.39172324444946 1 2.75462273915781 2543 2322 2244 1977 3787 3541 3307 1983 2177 3253 2451 2408 M10786 GO_VESICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. 176/377 Gene Ontology BP GO:0016050 5.68243975748455e-09 5.04881982447536e-08 3090 2318.27272727273 2452 5.16585433832896e-10 270 1.34595134950346 -1.01287911804052 -1 9.11657145480267 3086 292 2334 2734 270 1099 3715 4515 2452 2613 2391 2409 M15957 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. 31/133 Gene Ontology BP GO:0002440 3.3613644630702e-09 3.90170380050873e-08 3515 2730.09090909091 2452 3.05578588018728e-10 123 1.27031991830318 -0.906858267165316 -1 8.73628771317284 3515 1997 2452 2373 123 4542 3578 1672 2934 2409 4436 2410 M10178 GO_ETHER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHER_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. 5/13 Gene Ontology BP GO:0018904 2.97324658244742e-05 4.75207706791854e-05 3270 2328.72727272727 2453 2.97328636407511e-06 904 0.957830318467443 -0.957830318467443 -1 3.84374564080796 1754 2453 3550 3031 2826 904 1404 1664 3268 3266 1496 2411 M12542 GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of glial cell proliferation. 13/29 Gene Ontology BP GO:0060251 8.44591828516836e-06 1.48580695308038e-05 3940 2573 2453 7.6781370087973e-07 1167 1.26840744112097 -0.992366916093439 -1 5.6845822245217 3936 1247 2453 1188 2547 2437 3820 2895 1167 2300 4313 2412 M14983 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. 5/18 Gene Ontology BP GO:1902285 0.0294151784545622 0.0338810899440666 2285 2542.27272727273 2453 0.00298119542046845 1143 1.87214009608799 1.87214009608799 1 2.55468513270661 1143 2903 4329 2599 3838 1943 1542 2650 2453 2284 2281 2413 M16299 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE.html The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. 14/57 Gene Ontology BP GO:0001990 6.34405753083847e-05 9.57589698169149e-05 2265 2588.09090909091 2453 5.76749134493933e-06 1601 2.93153098701021 2.63118182851969 1 10.9360940371623 2265 3482 1601 3342 2957 2453 1844 2289 2259 3047 2930 2414 M12846 GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. 29/60 Gene Ontology BP GO:0042398 5.43789589156438e-06 9.96768678426113e-06 2075 2256 2454 4.94355393894864e-07 880 1.21299004452383 -1.1232726295376 -1 5.63142676392653 2073 2512 2644 3563 2454 880 1916 1784 2856 3057 1077 2415 M13361 GO_CELLULAR_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. 81/197 Gene Ontology BP GO:0044242 5.80221519095529e-09 5.0871514261604e-08 2475 2055.09090909091 2456 5.27474109659809e-10 279 1.52551304034337 -1.26317353645346 -1 10.3281504092538 2472 911 1636 2773 279 1602 3285 2456 2480 2213 2499 2416 M10303 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. 87/145 Gene Ontology BP GO:0043624 0.000180568058448299 0.00025796230626937 715 2476.63636363636 2457 1.64166255023555e-05 714 0.964144572074959 -0.750079822364828 -1 3.2115701897808 714 2767 3355 2457 3126 1160 1964 2156 3006 4217 2321 2417 M14135 GO_DETECTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS.html The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. 23/106 Gene Ontology BP GO:0009583 5.5115011348474e-06 1.00906544830822e-05 3190 2281.36363636364 2457 5.01046812951057e-07 449 1.9277320196006 2.35265646819689 1 8.9401588417546 3189 1389 989 1580 2457 4303 2727 3348 925 449 3739 2418 M11498 GO_DRUG_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSMEMBRANE_TRANSPORT.html The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 11/45 Gene Ontology BP GO:0006855 5.59741152954489e-06 1.02398667185488e-05 4255 2651.54545454545 2458 5.08856888269677e-07 981 2.32042980701359 2.25083952839272 1 10.7476248865085 4252 1408 1397 1160 2458 4094 4364 3453 981 1443 4157 2419 M11530 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 16/35 Gene Ontology BP GO:0043243 7.33196394344263e-06 1.30831316638755e-05 3480 2615.45454545455 2458 6.66544398079334e-07 1379 1.77960214304338 -1.7906497355298 -1 8.06685805672874 3477 2430 1379 1917 2517 3680 2458 3061 1686 1680 4485 2420 M11962 GO_RESPONSE_TO_NERVE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NERVE_GROWTH_FACTOR.html A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. 27/59 Gene Ontology BP GO:1990089 6.69223500944959e-08 2.40456849235948e-07 2955 2648.54545454545 2458 6.08385019365669e-09 1193 1.84562939852556 -1.85234872173709 -1 11.33975253574 2952 2178 2086 2458 1193 4048 1948 4421 1694 2883 3273 2421 M16926 GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 18/56 Gene Ontology BP GO:0002312 1.42960231775351e-07 4.33266551000623e-07 3280 2392.63636363636 2459 1.29963855513802e-08 1036 1.93025383739896 -1.36970941222313 -1 11.4015052842181 3279 3639 2199 2459 1452 1405 2910 3081 1036 2990 1869 2422 M10527 GO_RESPONSE_TO_COLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COLD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. 30/78 Gene Ontology BP GO:0009409 1.07576605408342e-08 7.11101207221337e-08 2200 2318.36363636364 2460 9.77969144857957e-10 517 1.87125963893012 1.97612095184891 1 12.4162913939324 2199 2226 1724 2920 517 3245 2460 2817 2844 1945 2605 2423 M14488 GO_NEGATIVE_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JNK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. 26/66 Gene Ontology BP GO:0046329 5.6305474854453e-06 1.02923747932766e-05 2375 2678.45454545455 2460 5.11869263271002e-07 1290 1.62117966791883 2.05002412781764 1 7.50553802915466 2373 3237 2444 4021 2460 3429 2242 1290 1677 3242 3048 2424 M15070 GO_MOTILE_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM_ASSEMBLY.html The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function. 21/57 Gene Ontology BP GO:0044458 1.07870490265523e-06 2.37704170053548e-06 4000 2685.45454545455 2461 9.80641301424205e-08 1466 1.54708473246344 -1.28019588417201 -1 8.07654657309183 4000 1466 2182 2046 2038 2461 3538 3892 1497 2772 3648 2425 M11103 GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 207/577 Gene Ontology BP GO:0019221 4.94252701316959e-08 1.94971562635059e-07 2465 2504.72727272727 2462 4.49320647655322e-09 1079 1.51968726792372 1.74859331586909 1 9.46559104979351 2462 1431 1840 3195 1079 4292 2723 2206 2782 2100 3442 2426 M13211 GO_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 43/128 Gene Ontology BP GO:0060191 1.37079437984096e-08 8.30887507258689e-08 2465 2361.27272727273 2463 1.24617671671111e-09 602 2.26687615758915 1.97544189421676 1 14.8990393754773 2463 3000 962 2693 602 3314 2237 3810 1708 1187 3998 2427 M16186 GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycosyl compound. 22/46 Gene Ontology BP GO:1901658 2.1754286939307e-07 6.06637563118333e-07 3180 2712.54545454545 2463 1.97766264458538e-08 1594 1.51217269151038 -0.977464586220483 -1 8.72682624781395 3180 2001 1909 2463 1594 4376 3934 1889 1959 2874 3659 2428 M16483 GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. 36/79 Gene Ontology BP GO:0006521 0.0031364233089803 0.00393259881814624 1370 2562.18181818182 2464 0.000285536698754227 1217 0.828213887782497 -0.897887023118701 -1 1.84920274575152 1369 2464 3390 2255 3496 1217 2228 2515 3221 4062 1967 2429 M10201 GO_INORGANIC_ION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_IMPORT_INTO_CELL.html The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 10/26 Gene Ontology BP GO:0099587 0.000661198210929669 0.000886242290227036 2175 2521.72727272727 2465 6.01270012875269e-05 1875 1.87168320107187 -1.87168320107187 -1 5.30334249719016 2175 3405 2251 2858 3289 2065 2548 1987 2821 2465 1875 2430 M16392 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 3/14 Gene Ontology BP GO:0045086 3.49171671042767e-05 5.50619713683508e-05 3820 2724.63636363636 2465 3.49177157602612e-06 1428 1.62763545806923 -1.28743493547295 -1 6.43500705324669 3816 1428 4558 2308 2859 2653 3500 2335 2286 1763 2465 2431 M11671 GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. 5/28 Gene Ontology BP GO:0044788 1.91556547587422e-05 3.15766752886256e-05 2470 2684.09090909091 2466 1.91558198833446e-06 683 2.96255494182564 -1.88794175960286 -1 12.3768237469072 2466 3785 3787 2925 3938 3424 2169 683 1913 2270 2165 2432 M14788 GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 11/27 Gene Ontology BP GO:0090322 5.73948120961346e-06 1.04667758272723e-05 3260 2613 2466 5.21772380285722e-07 1318 1.73931211431359 -1.06300058895955 -1 8.04067132666496 3256 2697 1887 1609 2466 2276 2432 4584 1318 2668 3550 2433 M16766 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. 87/198 Gene Ontology BP GO:0032387 2.14716762701677e-05 3.51526773351158e-05 2135 2614.36363636364 2467 1.95198962122109e-06 1706 1.28424936704367 -0.992964161608581 -1 5.30973386792597 2134 2875 2467 2344 2743 4548 1919 1975 3035 3012 1706 2434 M14310 GO_RHYTHMIC_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_BEHAVIOR.html The specific behavior of an organism that recur with measured regularity. 10/32 Gene Ontology BP GO:0007622 1.16841062784056e-06 2.55170768817673e-06 2890 2192.54545454545 2468 1.06219204398084e-07 422 1.89574379156004 2.61142836526905 1 9.84252946517226 2890 978 1719 2468 2052 4123 3241 972 422 2484 2769 2435 M14622 GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of guanylate cyclase activity. 8/14 Gene Ontology BP GO:0031282 1.19954135655338e-07 3.79391724691918e-07 4260 2695.18181818182 2468 1.19954142130386e-08 1017 1.75331152047829 -1.69271285927653 -1 10.4502083191263 4259 1186 4261 1017 1424 4254 3561 4131 1558 1528 2468 2436 M16607 GO_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION.html The addition of tubulin heterodimers to one or both ends of a microtubule. 13/34 Gene Ontology BP GO:0046785 5.88565426965084e-06 1.07123060658522e-05 2975 2436 2469 5.35060910507759e-07 362 1.70431885873196 1.82303163775022 1 7.86296957908361 2973 419 1738 801 2469 4632 4530 4481 362 1791 2600 2437 M11579 GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of activated T cell proliferation. 20/43 Gene Ontology BP GO:0046006 5.90088167791751e-06 1.07358125511642e-05 3535 2487.36363636364 2470 5.36445227766688e-07 995 2.12338514018466 -1.6640965773934 -1 9.79447882358568 3532 1152 1162 1587 2470 4368 3466 2968 995 2162 3499 2438 M13996 GO_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 19/41 Gene Ontology BP GO:0071887 1.71796649922033e-08 9.42850881309692e-08 2950 2294.81818181818 2470 1.56178773875984e-09 193 1.83568703977284 -1.78833421255457 -1 11.9714991094554 2947 193 1402 2166 691 4132 3737 2470 2796 1591 3118 2439 M14629 GO_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of B cell proliferation. 31/96 Gene Ontology BP GO:0030888 7.56110034158914e-06 1.34661253878014e-05 3615 2741.63636363636 2471 6.87375120744197e-07 1638 1.58025601959825 -1.12911588902835 -1 7.14484937169346 3611 1846 2010 1933 2522 4001 3502 2181 2471 1638 4443 2440 M12093 GO_INORGANIC_CATION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_IMPORT_INTO_CELL.html The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 10/26 Gene Ontology BP GO:0098659 0.000661198210929669 0.000886242290227036 2180 2521.63636363636 2472 6.01270012875269e-05 1876 1.87168320107187 -1.87168320107187 -1 5.30334249719016 2176 3406 2252 2859 3290 2066 2549 1970 2822 2472 1876 2441 M15469 GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of skeletal muscle contraction. 11/25 Gene Ontology BP GO:0014819 1.18401474586605e-06 2.58214206907284e-06 2560 2449 2472 1.07637762099061e-07 1469 1.90836316133562 -1.69910502451369 -1 9.89892649051161 2556 2733 1469 2812 2055 3617 2680 2191 2330 2024 2472 2442 M11731 GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/100 Gene Ontology BP GO:0032370 7.20212973259731e-05 0.000107869317253062 1935 2569.36363636364 2473 6.54760501744438e-06 1672 1.61174912702666 2.31623912775991 1 5.93526269517591 1933 3547 2231 1974 2981 2847 2298 2938 2473 3369 1672 2443 M12131 GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. 10/20 Gene Ontology BP GO:2000647 9.92593997010194e-07 2.20507843450638e-06 4495 2931.45454545455 2473 9.02358586225576e-08 1376 1.28222565610297 -1.05736556255092 -1 6.73266824376519 4491 2400 2140 1559 2017 3295 4354 4064 1376 2473 4077 2444 M12532 GO_SECRETORY_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. 18/40 Gene Ontology BP GO:0033363 3.82447622860631e-07 9.72455812125908e-07 2360 2575.45454545455 2474 3.47679717586615e-08 1751 1.17896610261703 1.31452857153964 1 6.57958980506571 2359 2474 2489 3515 1751 2469 1773 2618 3004 3475 2403 2445 M10928 GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 13/28 Gene Ontology BP GO:0015986 0.000593447419186568 0.000799586873848878 1025 2372.81818181818 2476 5.39643237647667e-05 866 0.52086945597519 -0.52086945597519 -1 1.49746961237401 1023 2476 3284 2532 3278 866 1317 1639 3883 4341 1462 2446 M13887 GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 14/43 Gene Ontology BP GO:0010800 6.10297665087996e-06 1.10687971054827e-05 1420 2391 2476 5.5481759828118e-07 183 1.99103627780462 -1.37001862632669 -1 9.15947966864886 4540 1166 1416 575 2476 3159 3878 3041 183 1416 4451 2447 M12843 GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. 13/28 Gene Ontology BP GO:0015985 0.000593447419186568 0.000799586873848878 1025 2397.81818181818 2477 5.39643237647667e-05 867 0.52086945597519 -0.52086945597519 -1 1.49746961237401 1024 2477 3285 2533 3279 867 1318 1812 3884 4434 1463 2448 M13033 GO_RESPONSE_TO_PROTOZOAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROTOZOAN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. 11/25 Gene Ontology BP GO:0001562 5.40364901780801e-06 9.92057824819399e-06 2480 2765.81818181818 2478 4.91242026392593e-07 1979 1.42541020828512 -0.81857354830188 -1 6.62033075153464 3941 2478 1979 3271 2451 2343 3519 2135 2478 2661 3168 2449 M11502 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 25/54 Gene Ontology BP GO:0090313 8.87649417005988e-08 2.9800117448726e-07 4630 2994.09090909091 2479 8.06954048018732e-09 1297 1.27288621226454 -0.942442714445536 -1 7.71065508066088 4630 1849 2340 2479 1297 3065 4602 4441 2474 1844 3914 2450 M13924 GO_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 20/54 Gene Ontology BP GO:0034605 0.0184845091897939 0.0216343776577296 1545 2667.72727272727 2480 0.00169469715798207 1542 1.84623937175558 1.90762619680253 1 2.85320968136874 1542 3579 2081 3958 3872 2480 1963 3021 3167 1710 1972 2451 M15938 GO_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORT.html The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 25/104 Gene Ontology BP GO:0015908 5.10778175376974e-05 7.83204447911258e-05 2160 2385.63636363636 2481 4.64354576905715e-06 385 1.67279753316993 1.8240957297071 1 6.37594641578747 2157 385 1338 2481 2921 3494 3177 2320 3327 1847 2795 2452 M16434 GO_PROTEIN_O_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. 44/116 Gene Ontology BP GO:0006493 1.31987684404009e-06 2.83057191079821e-06 4020 2988.45454545455 2481 1.1998887599027e-07 1596 1.37576863746629 -1.39549500046772 -1 7.08534227994095 4018 1596 2481 2386 2097 3373 3957 4427 2347 1796 4395 2453 M10476 GO_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of a cytokine. 305/853 Gene Ontology BP GO:0001817 4.15090690565045e-08 1.72385158881351e-07 3260 2496.54545454545 2482 3.77355180360798e-09 668 1.71393115076619 -1.44578749623891 -1 10.7605385739934 3259 2166 668 2277 1013 3582 3182 3413 2482 869 4551 2454 M13270 GO_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of chemokine production. 48/124 Gene Ontology BP GO:0032642 1.88135380847927e-07 5.3854042742104e-07 2700 2494.90909090909 2482 1.71032179033209e-08 1548 1.49109210688907 1.54252386449217 1 8.67674329950333 2700 1783 1679 2293 1548 3936 2482 3314 2722 1773 3214 2455 M15554 GO_RENAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_ABSORPTION.html A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). 9/35 Gene Ontology BP GO:0070293 0.000421574915968138 0.000578590699036378 1840 2474.81818181818 2483 4.21654913762569e-05 561 2.25608945932682 2.37153246680872 1 6.78035553288314 1839 2483 4421 1857 3474 1476 561 3759 2873 3091 1389 2456 M11456 GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. 95/214 Gene Ontology BP GO:1901293 8.73577978539296e-08 2.9498345849876e-07 2355 2647.09090909091 2484 7.94161830206738e-09 1275 1.11388055860652 -0.962356480620538 -1 6.75203043284008 2354 2121 2810 3949 1290 1275 2287 3693 3482 3373 2484 2457 M15859 GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). 8/19 Gene Ontology BP GO:0048016 0.000502149606135158 0.000683117673977597 1140 2474.63636363636 2484 5.02263111636881e-05 1138 1.85618204990385 1.85618204990385 1 5.45421968925413 1138 3760 4468 2484 3270 1467 1794 1387 2770 2937 1746 2458 M10120 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. 60/144 Gene Ontology BP GO:0031333 1.39868753647705e-06 2.97894781278117e-06 3265 2845 2486 1.27153493247028e-07 924 1.29824933174592 -1.30271441136658 -1 6.65937044344718 3264 924 2412 1964 2112 4540 2486 4026 1832 3154 4581 2459 M12785 GO_PEPTIDYL_THREONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_THREONINE_MODIFICATION.html The modification of peptidyl-threonine. 44/87 Gene Ontology BP GO:0018210 3.32019812844926e-07 8.64107618295399e-07 2490 2545 2486 3.01836239047941e-08 1137 1.16813621230956 1.32242215490192 1 6.57477869799959 2486 1137 2807 2055 1713 3663 2346 2180 3598 3103 2907 2460 M11700 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. 10/33 Gene Ontology BP GO:0002675 9.23274125726609e-05 0.000136347384406764 2090 2232.81818181818 2487 8.39375340958008e-06 1329 1.83013659538191 2.13455690781404 1 6.56661896869474 2089 2739 1695 2487 3022 2675 1715 1573 2642 1329 2595 2461 M16301 GO_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that modulates the frequency, rate or extent of neutrophil migration. 15/60 Gene Ontology BP GO:1902622 6.91988097295339e-07 1.60675969505168e-06 2400 2537.36363636364 2487 6.29080286321274e-08 1923 1.60838246459012 1.6638075905352 1 8.65048844943686 2400 2099 1953 2907 1923 2818 2487 2758 3523 2047 2996 2462 M12867 GO_OVULATION_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE_PROCESS.html A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 48/121 Gene Ontology BP GO:0022602 8.94260736259213e-08 2.99552718315086e-07 2490 2472.54545454545 2488 8.12964338735742e-09 1050 1.76870841856391 1.71650426026184 1 10.7104525988978 2488 2215 1050 2095 1300 3891 2577 4305 2546 1248 3483 2463 M11356 GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 10/23 Gene Ontology BP GO:0060390 3.39550466708102e-06 6.4744674206395e-06 2685 2609.27272727273 2492 3.08682718886575e-07 1786 1.84416974817088 -1.50465349684975 -1 8.88252867563866 2683 3404 1786 2473 2353 3274 2492 2119 2542 2469 3107 2464 M11217 GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. 38/75 Gene Ontology BP GO:0070228 3.88139067493673e-05 6.07800907377107e-05 2100 2722.63636363636 2493 3.52859923161888e-06 1651 2.21618345881955 2.43198582428373 1 8.67361271921475 2097 4074 1651 3674 2863 3692 2264 2493 2410 2231 2500 2465 M13023 GO_VITAMIN_D_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). 3/25 Gene Ontology BP GO:0042359 0.0059284054474356 0.0072378612917285 1810 2699.09090909091 2493 0.000594428078238065 1266 1.57792514413848 1.57792514413848 1 3.13507815577072 1808 3651 3995 2493 4577 1954 1266 1759 3291 2852 2044 2466 M13350 GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 25/86 Gene Ontology BP GO:0050922 0.000490725147732373 0.000668771558846784 2885 2265.54545454545 2493 4.46213310499633e-05 1099 1.78766530073746 2.28880682251445 1 5.26818558159217 1198 2883 1099 1956 3252 2881 2068 2882 2493 1462 2747 2467 M15686 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. 26/69 Gene Ontology BP GO:0002711 0.00104788591364148 0.00137477657446663 1900 2509.27272727273 2493 9.53077606482433e-05 1529 1.29123663541329 -1.1951167042491 -1 3.43012036806218 1896 2620 2493 3355 3357 1529 2699 1854 3591 2383 1825 2468 M15673 GO_AXONEME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_ASSEMBLY.html The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 28/98 Gene Ontology BP GO:0035082 8.39936218269472e-06 1.47832595201864e-05 2135 2310.63636363636 2494 7.63581295520271e-07 1213 1.46305919441435 -1.61915439540039 -1 6.55992417356639 2133 2850 2494 2874 2546 1223 2836 1213 2380 3371 1497 2469 M10423 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN.html The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. 6/27 Gene Ontology BP GO:0001991 9.02235218553931e-05 0.000133495159966409 1690 2363 2496 9.02271851924769e-06 966 2.03383382626067 2.03383382626067 1 7.31482813030937 1688 2496 3582 3785 3027 1712 966 1101 2631 3410 1595 2470 M10435 GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 10/25 Gene Ontology BP GO:0043555 1.22808455600164e-07 3.84951540326431e-07 2815 2387.18181818182 2496 1.11644056777802e-08 1401 0.871360078800742 -0.76557493599492 -1 5.18842990255377 2815 1626 3003 2447 1401 1550 2648 2951 2496 3188 2134 2471 M13180 GO_POSITIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_T_CELL_SELECTION.html The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. 11/30 Gene Ontology BP GO:0043368 0.00136475917105568 0.00177346118981571 2230 2567.09090909091 2496 0.000124146048063357 1494 1.29712459182836 1.44374472451496 1 3.31260419629855 2226 1814 2496 2337 3389 3260 2958 1494 1765 3321 3178 2472 M14914 GO_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 38/70 Gene Ontology BP GO:0010332 8.69337629656061e-06 1.52314513754456e-05 2500 2610.81818181818 2498 7.90310058993506e-07 1594 1.68073827475031 2.07407968812581 1 7.51569576301989 2498 2548 1882 1683 2556 4378 3767 1594 1956 1923 3934 2473 M13721 GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. 97/242 Gene Ontology BP GO:0045017 2.00048711073662e-07 5.64979419413024e-07 2500 2084.45454545455 2500 1.818624811494e-08 704 1.49410481729514 -1.38166230496239 -1 8.66540670701266 2500 1833 2502 2587 1573 704 3190 1141 2591 3015 1293 2474 M13169 GO_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium. 26/89 Gene Ontology BP GO:0003341 0.000783593897306732 0.00104277055465611 2195 2416.18181818182 2501 7.12611942077058e-05 1308 1.48118913336329 -1.70280986474415 -1 4.09977275934022 2195 2782 2470 2612 3322 1394 2737 1308 2501 3620 1637 2475 M15769 GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to a muscle, across a synapse. 9/40 Gene Ontology BP GO:0007274 0.00195787098079429 0.00250217312519348 1600 2621.90909090909 2503 0.000195959808921735 831 1.34900061881286 1.29269799704003 1 3.25788375292505 1598 3615 4454 3137 3638 2082 831 2503 2621 2362 2000 2476 M12988 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 33/84 Gene Ontology BP GO:0046364 0.000253465776762038 0.000355756227782994 1440 2250.90909090909 2504 2.30449985182171e-05 563 1.41267887624856 -1.1792989344542 -1 4.52258318553986 1436 3292 2504 3142 3351 563 1466 1677 2974 3346 1009 2477 M16793 GO_PROGESTERONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROGESTERONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. 6/26 Gene Ontology BP GO:0042448 5.57116891310892e-06 1.01958759414918e-05 4485 2986.45454545455 2504 5.57118288022358e-07 1340 1.30127548159537 -1.2084980426413 -1 6.0294266367861 4482 1340 4619 1524 2478 4100 4317 1877 2504 1742 3868 2478 M11183 GO_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE.html Any process that modulates the frequency, rate or extent of a defense response. 435/1123 Gene Ontology BP GO:0031347 1.16804610249027e-08 7.50102082138637e-08 3175 2433.27272727273 2505 1.06186009881071e-09 544 1.60131438993648 -1.31368208926643 -1 10.5906660004964 3171 1712 1122 2505 544 2822 3194 3158 2270 1798 4470 2479 M13102 GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS.html Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 92/252 Gene Ontology BP GO:0010565 6.02185160228905e-07 1.42723108674977e-06 4480 2784 2505 5.47441204599462e-08 896 1.47820638797497 1.74857455542878 1 8.02095896522304 4479 1285 2505 896 1883 2288 4551 3671 1927 3251 3888 2480 M13299 GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. 10/26 Gene Ontology BP GO:0006688 0.0123012413053888 0.0146485415185741 1475 2534.72727272727 2505 0.00112459696927646 1474 1.16146755786907 1.27314112671022 1 1.97753509388869 1474 2527 2381 2719 3849 2379 1550 2843 2505 3807 1848 2481 M12115 GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY.html The formation or destruction of chromatin structures. 96/208 Gene Ontology BP GO:0006333 0.00699957981417266 0.00849204313488467 855 2449.18181818182 2506 0.000638359052034394 853 1.60578769059047 -1.49146813836756 -1 3.08698685594584 853 3421 2089 2611 3606 1942 2478 2550 2997 1888 2506 2482 M11586 GO_ACETYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. 13/26 Gene Ontology BP GO:0006084 0.00178953634029643 0.00229842800221199 2070 2900.63636363636 2507 0.000162817604985297 1112 1.14655315268378 -1.14655315268378 -1 2.80822418361487 2069 4268 2507 4493 3421 1112 2014 1835 4389 3935 1864 2483 M12648 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation. 16/54 Gene Ontology BP GO:0002577 0.0015391572988655 0.00199006052315025 1670 2446.27272727273 2507 0.000140021379572311 1624 2.30687527717546 2.53674172028013 1 5.784147049587 1669 3775 1760 2964 3402 2523 1624 1965 2507 1682 3038 2484 M15609 GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. 7/18 Gene Ontology BP GO:0051044 0.000201156339164039 0.000285530077266472 2545 2603.27272727273 2507 2.01174550226906e-05 1114 1.66136982461866 -1.06742024976122 -1 5.46602756223992 2545 2073 4430 2642 3157 1629 1987 4572 1114 1980 2507 2485 M15951 GO_ORGANELLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_LOCALIZATION.html Any process in which an organelle is transported to, and/or maintained in, a specific location. 280/627 Gene Ontology BP GO:0051640 1.38471897543521e-08 8.32189868277674e-08 3475 2733.90909090909 2508 1.25883544013716e-09 609 1.54982617594284 -1.10448262689729 -1 10.1852510702421 3473 3597 2181 3154 609 2148 3219 2212 2350 2508 4622 2486 M11453 GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 6/15 Gene Ontology BP GO:0060456 0.000113815809472337 0.000166230513803101 1070 2319.54545454545 2509 1.13821639209887e-05 631 3.17771512103643 3.17771512103643 1 11.1479298537584 1263 3500 3749 3405 3954 1066 631 954 2509 3418 1066 2487 M15880 GO_LIPID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_OXIDATION.html The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. 48/91 Gene Ontology BP GO:0034440 0.00020047999694376 0.000284657072113112 2625 2230.90909090909 2509 1.82271153154482e-05 345 1.27508578617128 -1.00712241916064 -1 4.1966989967736 2625 345 2323 2901 3140 949 2918 2509 2933 2387 1510 2488 M12149 GO_NEGATIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 32/67 Gene Ontology BP GO:0010507 5.18983842780008e-07 1.25436854868692e-06 1655 2395.09090909091 2511 4.71803604735676e-08 1147 1.13076308434867 1.52977517521721 1 6.19453439863461 1652 2511 2716 2710 1848 2280 1147 3126 3198 2893 2265 2489 M14264 GO_PROTEIN_DEGLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEGLYCOSYLATION.html The removal of sugar residues from a glycosylated protein. 11/22 Gene Ontology BP GO:0006517 5.31308715424856e-05 8.10669196752417e-05 1850 2251.45454545455 2511 4.83019588340604e-06 301 0.830040832616808 -0.770188072284761 -1 3.15220639907049 1847 1483 2678 3503 3198 411 301 2511 4267 3860 707 2490 M15721 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. 32/65 Gene Ontology BP GO:2001238 2.87472666385589e-06 5.59637563953161e-06 3985 2950.09090909091 2511 2.61339129113697e-07 1845 1.52496884044665 1.68784987692183 1 7.43468409266358 3982 1845 2272 2090 2311 3454 4090 3305 2307 2511 4284 2491 M11976 GO_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE.html Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. 590/1913 Gene Ontology BP GO:0006952 1.48748226735828e-08 8.70405107804676e-08 2515 2502 2513 1.487482277315e-09 194 1.73308718531976 1.9692294843775 1 11.3582489242024 2513 2165 3836 2496 680 3947 2634 3017 2305 194 3735 2492 M13149 GO_HEPATOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a hepatocyte, the main structural component of the liver. 9/17 Gene Ontology BP GO:0097284 6.534262527285e-06 1.17500313377941e-05 2935 2547.63636363636 2513 6.53428174082856e-07 738 2.02873439978679 -1.83670035152933 -1 9.28405719888153 2931 1491 4022 2506 2513 2178 3403 2901 738 2347 2994 2493 M11534 GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. 6/17 Gene Ontology BP GO:0072202 1.82028958406688e-06 3.74296038034655e-06 2515 2330.63636363636 2515 1.82029107512297e-07 369 2.1571491487483 1.8385202833723 1 10.8665555772872 2515 875 3764 1202 2214 2763 2883 4223 369 390 4439 2494 M10270 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 7/25 Gene Ontology BP GO:0044550 5.25560766621254e-07 1.26696710250388e-06 2995 2419.72727272727 2516 5.25560890917648e-08 368 2.16159394797483 -2.21062350778279 -1 11.832912688404 2992 3071 3560 2507 1871 2991 4015 771 368 1955 2516 2495 M11017 GO_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 19/43 Gene Ontology BP GO:0060996 2.53713487804617e-08 1.21690920089996e-07 3890 2710.90909090909 2516 2.30648627936865e-09 423 1.86332629504359 2.09716855753939 1 11.9600781410913 3889 2516 1850 1254 849 4557 4069 3829 423 2055 4529 2496 M11054 GO_BARBED_END_ACTIN_FILAMENT_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BARBED_END_ACTIN_FILAMENT_CAPPING.html The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. 9/19 Gene Ontology BP GO:0051016 6.6370098465787e-06 1.19222738442811e-05 2875 2104.63636363636 2516 6.63702966911689e-07 277 1.19425127619675 -1.58792643111915 -1 5.45822219828724 2871 577 3677 1688 2516 2656 3365 896 277 3066 1562 2497 M16866 GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. 8/14 Gene Ontology BP GO:0046498 0.0026912517846268 0.00339090421601689 2520 2809 2516 0.000269451662706889 1898 2.01691817947862 -2.01691817947862 -1 4.62379824444319 2516 3780 4627 3513 3490 2022 2222 1917 1898 2945 1969 2498 M10262 GO_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 112/205 Gene Ontology BP GO:0010212 4.57305994475055e-06 8.48290744046217e-06 2520 2753.63636363636 2517 4.15733586421047e-07 1423 1.62530620273363 2.16707807560944 1 7.65132981674997 2517 3310 1941 2292 2417 4217 3492 1423 2318 2843 3520 2499 M13973 GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 17/45 Gene Ontology BP GO:0061036 2.27320547683468e-07 6.31002192826494e-07 3490 2929.54545454545 2517 2.06655064701764e-08 1603 1.76958234063653 1.8498401096279 1 10.1842590218681 3490 2517 1963 2247 1603 4404 3131 4091 2420 1813 4546 2500 M14633 GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 8/21 Gene Ontology BP GO:0010649 0.000108659774298743 0.000159050230791003 1510 2449.27272727273 2517 1.08665087790357e-05 647 1.47665308224391 1.82133237232598 1 5.20661913545732 1507 2485 4263 2517 3558 1225 647 4493 2554 2931 762 2501 M14366 GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS.html A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. 15/34 Gene Ontology BP GO:0034067 1.28507883400332e-07 3.98040095148595e-07 2005 2621.63636363636 2520 1.16825355369838e-08 973 0.676797003802044 -0.732565872420516 -1 4.02080014932432 2005 2520 3149 3400 1417 973 2664 2440 4314 4513 1443 2502 M11016 GO_RESPONSE_TO_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANGIOTENSIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. 13/29 Gene Ontology BP GO:1990776 5.12039935741117e-07 1.24016766909025e-06 3455 2698.09090909091 2523 4.65490959014644e-08 1777 1.5680698883038 -1.97604386960808 -1 8.59738145261361 3454 2731 1908 2336 1844 4017 2523 1873 2754 1777 4462 2503 M16125 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST.html Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. 78/211 Gene Ontology BP GO:0050691 1.27303764663209e-06 2.74661421622342e-06 3170 2817 2523 1.15730762116395e-07 937 1.64643492647717 -1.3505767691799 -1 8.49928512542941 3166 3949 2209 4480 2084 937 3539 2523 2156 3848 2096 2504 M10954 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. 38/71 Gene Ontology BP GO:2001021 7.2029436945948e-08 2.53935213166315e-07 2445 2468.63636363636 2524 6.5481308458399e-09 1226 1.1437435493564 1.34195723183545 1 7.00214068952523 2444 2770 2680 2053 1226 3908 1754 1712 2524 3341 2743 2505 M10852 GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT.html The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. 7/16 Gene Ontology BP GO:0099514 0.00452933364432662 0.00559003086406393 1735 2647.36363636364 2525 0.000453859190188104 1322 0.853602751548371 -0.853602751548371 -1 1.7848685612536 1735 2601 3649 2525 3560 1322 2282 1773 4119 3542 2013 2506 M11261 GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT.html The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. 7/16 Gene Ontology BP GO:0048490 0.00452933364432662 0.00559003086406393 1740 2658.54545454545 2526 0.000453859190188104 1323 0.853602751548371 -0.853602751548371 -1 1.7848685612536 1736 2602 3718 2526 3561 1323 2283 1813 4120 3548 2014 2507 M16054 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the rate of production of a cytokine. 119/317 Gene Ontology BP GO:0001818 7.09246195957785e-07 1.64404897046031e-06 2390 2622.36363636364 2526 6.4476947691633e-08 1144 1.73116021195452 1.92813493644297 1 9.29482205855327 2390 3288 1144 3455 1931 4257 2539 2526 2428 1572 3316 2508 M11922 GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. 7/16 Gene Ontology BP GO:0099517 0.00452933364432662 0.00559003086406393 1740 2668.72727272727 2527 0.000453859190188104 1324 0.853602751548371 -0.853602751548371 -1 1.7848685612536 1737 2603 3823 2527 3562 1324 2284 1807 4121 3553 2015 2509 M14527 GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros. 8/26 Gene Ontology BP GO:0072010 1.16720862098756e-05 2.00049820127178e-05 2500 2549.18181818182 2528 1.16721475172473e-06 836 2.12903768350195 2.0536364326136 1 9.28635231540219 2499 1417 4247 836 2633 3513 2528 3794 1981 969 3624 2510 M16177 GO_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 13/24 Gene Ontology BP GO:0070227 4.47879474148339e-08 1.82412666532521e-07 2945 2114.63636363636 2529 4.07163166605765e-09 552 1.23262310388139 -0.824030627938918 -1 7.71065633357941 2943 571 2529 1680 1037 3646 2697 552 2992 2972 1642 2511 M14571 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 38/72 Gene Ontology BP GO:0051881 7.87086533403788e-06 1.39749245682363e-05 2425 2747.36363636364 2531 7.15535772136973e-07 2208 1.44058141715508 1.695415390743 1 6.49179666756538 2423 2353 2576 2416 2531 4484 2624 3161 2439 3006 2208 2512 M12512 GO_NITROGEN_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_COMPOUND_TRANSPORT.html The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 254/690 Gene Ontology BP GO:0071705 4.11897845787682e-08 1.71365743547689e-07 4240 2814.81818181818 2532 3.74452594090448e-09 1010 1.59625659109159 -1.37570513653803 -1 10.0255615594244 4239 4214 1868 4569 1010 1406 4179 1931 2532 2595 2420 2513 M12943 GO_PLATELET_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_MORPHOGENESIS.html Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. 17/38 Gene Ontology BP GO:0036344 7.89771802715808e-06 1.40172418960608e-05 3845 2739.63636363636 2532 7.17976943554185e-07 600 1.66470866172587 -0.91765998214753 -1 7.4997684781816 3844 2427 1639 2051 2532 4527 4236 1467 600 2830 3983 2514 M14976 GO_FEMALE_MEIOTIC_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_MEIOTIC_DIVISION.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. 10/32 Gene Ontology BP GO:0007143 0.00175584345813293 0.00225702690368527 1775 2813.18181818182 2532 0.000159749671212263 1764 1.24947130285592 1.38922758039828 1 3.06945498920218 1773 4053 2532 4320 3419 2514 1764 1795 3399 3212 2164 2515 M13750 GO_GLYCINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycine, aminoethanoic acid. 6/20 Gene Ontology BP GO:0006544 0.00199469256714266 0.00254502819160301 2535 2650.45454545455 2533 0.000199648529161234 1320 0.978696471473125 -1.02155401628224 -1 2.35688592081736 2533 2024 4128 2850 3452 1320 1551 2096 3627 3439 2135 2516 M10717 GO_NEGATIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. 18/49 Gene Ontology BP GO:0014014 9.91004415099977e-07 2.20260100493499e-06 2535 2400.36363636364 2535 9.0091351045881e-08 966 1.33153173053701 -0.692421338787212 -1 6.99216639251367 2535 1074 2208 1538 2016 4125 2895 3304 966 2984 2759 2517 M12604 GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER.html The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. 12/41 Gene Ontology BP GO:0060795 8.05427131786379e-06 1.425151742715e-05 2345 2786.72727272727 2535 7.32209164087574e-07 1913 1.28485637070132 1.23643223268051 1 5.77988990574654 2345 1913 2190 2403 2535 3442 2440 3960 3487 2799 3140 2518 M13764 GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. 4/27 Gene Ontology BP GO:0060219 5.55840578670712e-05 8.47188114435697e-05 2065 2639.09090909091 2535 5.55854482303868e-06 1236 1.89040749594191 2.30535033354432 1 7.14553051992186 2065 2605 4130 2366 2954 2535 1879 2720 4106 1236 2434 2519 M13056 GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. 6/38 Gene Ontology BP GO:0071875 1.65743923230723e-06 3.45554124634147e-06 2155 2615.36363636364 2536 1.65744046850569e-07 343 1.67970409868482 1.67970409868482 1 8.51554744558173 2151 3595 4001 3713 3008 3127 2036 343 2364 2536 1895 2520 M13975 GO_MUSCLE_ATROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ATROPHY.html A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. 5/18 Gene Ontology BP GO:0014889 0.000124037113362704 0.000180195343348885 2260 2704.45454545455 2536 1.240440372491e-05 970 1.71779890566976 -1.71779890566976 -1 5.97044956704707 2259 2536 4168 3454 3401 2194 3135 970 3485 2280 1867 2521 M11131 GO_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. 73/119 Gene Ontology BP GO:0032543 0.00226590143365286 0.00287133743352899 265 2518.54545454545 2537 0.000206203507393271 263 0.630288911285444 -0.630706102442903 -1 1.48720180661206 263 2677 3484 2537 3458 1133 1898 1995 3905 4257 2097 2522 M12545 GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. 25/62 Gene Ontology BP GO:1903523 7.72590445670923e-08 2.66701668345732e-07 2545 2489.81818181818 2537 7.02354975275057e-09 1257 1.5351626284466 -1.27470488563618 -1 9.36810008919277 2544 2046 1759 2332 1257 3345 2537 2981 3005 2222 3360 2523 M13634 GO_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_SORTING_PATHWAY.html A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. 6/12 Gene Ontology BP GO:0071985 1.50429702555523e-06 3.18053328308421e-06 2770 2655.36363636364 2539 1.50429804386549e-07 1744 1.681654184091 -1.15761435639984 -1 8.58165530619592 2768 2163 4109 2588 2152 1744 2403 3771 2146 2539 2826 2524 M14870 GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 17/24 Gene Ontology BP GO:0090312 1.84274897846437e-05 3.05240225009278e-05 1835 2354.72727272727 2539 1.67524037613958e-06 998 1.69608040185239 2.04673493562417 1 7.10898793807363 1832 3154 2207 3106 2716 2934 2339 1242 998 2835 2539 2525 M13730 GO_ECTODERMAL_PLACODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_DEVELOPMENT.html The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0071696 1.85007886995725e-06 3.78744100229785e-06 3370 2700.36363636364 2540 1.85008041021538e-07 1382 1.83857450233703 -1.83857450233703 -1 9.25299172509079 3370 1423 4123 1382 2221 2913 4143 3773 1924 2540 1892 2526 M15299 GO_RETINA_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_HOMEOSTASIS.html A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. 36/134 Gene Ontology BP GO:0001895 7.96995767033876e-06 1.41346499096191e-05 2580 2731.54545454545 2542 7.24544231210442e-07 1592 2.28277265235253 -1.34661264881311 -1 10.2765657945379 2576 4006 1592 3452 2533 4266 2542 2226 1676 2841 2337 2527 M13839 GO_SIGNAL_RELEASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_RELEASE.html The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. 81/246 Gene Ontology BP GO:0023061 7.993492501992e-07 1.82377325242009e-06 3615 2725.90909090909 2545 7.26681400577599e-08 975 1.63188107176679 1.88247445758174 1 8.69352822297082 3614 1940 1333 1854 1966 3761 4042 3745 2545 975 4210 2528 M14580 GO_REGULATION_OF_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_FUSION.html Any process that modulates the frequency, rate or extent of myoblast fusion. 6/24 Gene Ontology BP GO:1901739 0.000830875824221331 0.00110221612910275 1275 2550.63636363636 2545 8.31186647381452e-05 667 2.10717953984502 2.10717953984502 1 5.78535042165655 1274 2870 4252 2577 3853 1821 667 2026 4111 2545 2061 2529 M14292 GO_NEUTRAL_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. 40/116 Gene Ontology BP GO:0006638 2.83922343475564e-08 1.32221809504217e-07 2070 2235.54545454545 2546 2.58111224672492e-09 882 1.81960873828706 1.86296777058275 1 11.6185872032191 2070 1530 921 2546 882 3281 2558 3634 2891 956 3322 2530 M11590 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 6/23 Gene Ontology BP GO:0010744 0.000815250063527209 0.00108303463375017 2550 2626.63636363636 2547 8.15549302743197e-05 1602 2.25850478180566 -2.25850478180566 -1 6.21680469610331 2547 2451 3774 2906 3342 1978 2200 1602 2900 3420 1773 2531 M16269 GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 428/1010 Gene Ontology BP GO:0051129 9.50745227555164e-09 6.64805736677504e-08 2295 2422.72727272727 2549 8.64313846967157e-10 463 1.53072561684234 1.85204877619489 1 10.1983027494935 2295 3569 1926 2885 463 3899 1997 1516 2549 2978 2573 2532 M11580 GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that activates or increases the frequency, rate, or extent of a homeostatic process. 110/279 Gene Ontology BP GO:0032846 0.00030181767639873 0.000420696328886011 2415 2596.09090909091 2550 2.74417355159859e-05 1422 1.71042452229964 2.15740376517195 1 5.36018157609115 2412 3079 1794 2661 3200 4320 2550 1422 2919 2377 1823 2533 M15688 GO_ECTODERMAL_PLACODE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_MORPHOGENESIS.html The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0071697 1.85007886995725e-06 3.78744100229785e-06 3375 2730.09090909091 2550 1.85008041021538e-07 1383 1.83857450233703 -1.83857450233703 -1 9.25299172509079 3371 1424 4441 1383 2222 2914 4144 3764 1925 2550 1893 2534 M15785 GO_ECTODERMAL_PLACODE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_FORMATION.html The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0060788 1.85007886995725e-06 3.78744100229785e-06 3375 2733.27272727273 2551 1.85008041021538e-07 1384 1.83857450233703 -1.83857450233703 -1 9.25299172509079 3372 1425 4457 1384 2223 2915 4145 3774 1926 2551 1894 2535 M14267 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. 9/21 Gene Ontology BP GO:0071636 7.48617343444094e-05 0.000111979069768393 2120 2518.36363636364 2553 7.48642563896577e-06 1345 1.83495516074731 1.83495516074731 1 6.72955848108001 2117 2105 4215 2657 3000 2553 1557 1345 3015 2356 2782 2536 M15318 GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY.html Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. 21/75 Gene Ontology BP GO:0034260 4.31838789822523e-07 1.07450562762378e-06 3420 2433.54545454545 2553 3.92580795080307e-08 946 1.25820542647128 -1.28939218322876 -1 6.97119253964402 3417 2654 2553 2516 1791 2099 3217 946 3106 2773 1697 2537 M16655 GO_RESPONSE_TO_IRON_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IRON_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. 21/50 Gene Ontology BP GO:0010039 4.02327458983319e-06 7.55666016205319e-06 2945 2653.09090909091 2553 3.65752904314582e-07 1719 1.53549618069651 2.00160040510443 1 7.30011114545975 2942 2553 1935 2743 2388 4514 3402 1719 2021 1834 3133 2538 M10312 GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE.html Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. 41/108 Gene Ontology BP GO:0035019 0.000390041434191035 0.000537537067067075 2555 2761.45454545455 2554 3.54646002194985e-05 1952 1.75542620056848 1.90140195316973 1 5.32776681445455 2554 3363 1952 2102 3227 3865 2341 3969 2236 2173 2594 2539 M13051 GO_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that modulates the frequency, rate or extent of a response to a food stimulus. 10/22 Gene Ontology BP GO:0032095 8.64987994885298e-06 1.51676783465162e-05 1495 2482.27272727273 2554 7.86355814393038e-07 1495 1.90967974425188 1.90967974425188 1 8.54267510569877 1495 2668 2363 3648 2554 1742 1603 3263 2905 3203 1861 2540 M16303 GO_PENTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. 6/18 Gene Ontology BP GO:0019321 5.16766085348899e-05 7.91079767317817e-05 2555 1975.54545454545 2554 5.1677810286563e-06 307 0.968460390088684 -0.968460390088684 -1 3.68742601120644 993 2572 4544 2554 3069 503 307 867 2945 2554 823 2541 M13757 GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR.html The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 12/22 Gene Ontology BP GO:0042994 1.51062411402643e-06 3.1914343581037e-06 2555 2423.36363636364 2555 1.37329559208494e-07 1486 1.06513269228759 -0.744148955204099 -1 5.43401305758861 2555 2280 2740 1858 2124 1537 2861 2678 1486 3899 2639 2542 M15749 GO_LIPID_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_LOCALIZATION.html Any process in which a lipid is transported to, or maintained in, a specific location. 118/373 Gene Ontology BP GO:0010876 2.58302539433813e-08 1.2262767797456e-07 2850 2292.45454545455 2555 2.34820493151408e-09 450 1.78909997711022 2.10996781716308 1 11.4781129920541 2848 1279 450 1392 859 4047 3189 4439 2555 495 3664 2543 M11766 GO_SPERM_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MOTILITY.html Any process involved in the controlled movement of a sperm cell. 34/121 Gene Ontology BP GO:0030317 1.96645648113499e-06 3.99398838228774e-06 3815 2824.72727272727 2556 1.78768930803839e-07 1466 2.02884890098139 -2.38188757082898 -1 10.167154921276 3815 2466 2059 2556 2208 4326 3030 2378 1466 3098 3670 2544 M14489 GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 35/109 Gene Ontology BP GO:0010830 2.39368901333324e-07 6.59187312509268e-07 2710 2433.72727272727 2557 2.17608115797848e-08 712 1.80211127730359 -1.72074721869161 -1 10.3397219611849 2710 1533 1148 2557 1619 3839 2091 4188 2619 712 3755 2545 M15197 GO_GLYCEROLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. 18/46 Gene Ontology BP GO:0046503 7.96921209530252e-05 0.000118821617721547 1830 2239.27272727273 2557 7.24500071292922e-06 918 2.41118824467774 2.9823847096863 1 8.78519645836454 1828 2557 918 2665 2993 3055 2567 1340 2322 1479 2908 2546 M10390 GO_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 22/68 Gene Ontology BP GO:0010043 9.52747927949536e-06 1.65430390032524e-05 2920 2057.27272727273 2558 8.66138230921552e-07 526 2.06937863104169 -1.47823210553342 -1 9.18465358576103 2919 1391 659 1307 2586 3922 2762 2558 969 526 3031 2547 M16164 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. 21/60 Gene Ontology BP GO:0002717 0.000108093795104377 0.000158321605889471 2565 2585 2561 9.82719150008091e-06 1920 1.46379984165885 -1.13155530462565 -1 5.16400870366013 2561 2092 1955 2736 3039 1920 3108 3482 3162 2242 2138 2548 M12994 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. 9/26 Gene Ontology BP GO:0032232 0.00227506426598161 0.00288137571929968 1165 2674 2562 0.000227739679039367 870 1.50257364998911 1.50257364998911 1 3.54329252710675 1162 3589 3991 2562 4401 1700 870 1932 3862 3747 1598 2549 M13302 GO_ONE_CARBON_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_METABOLIC_PROCESS.html The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. 20/37 Gene Ontology BP GO:0006730 8.448266974224e-06 1.48580695308038e-05 2565 2839.09090909091 2562 7.68027219706255e-07 2025 1.35763971733956 -0.867998734839736 -1 6.08449175910308 2562 2471 2026 3025 2548 3941 2025 3520 3454 3163 2495 2550 M15934 GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION.html The directed movement of the mitochondrion to a specific location. 14/23 Gene Ontology BP GO:0051654 0.082386180881833 0.0891201423493528 1790 2831.63636363636 2562 0.00778577381970237 1789 1.39366513858928 1.37965650086038 1 1.35839724640377 1789 3610 2486 2786 3858 2642 1995 4602 2371 2447 2562 2551 M14919 GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. 9/23 Gene Ontology BP GO:0051497 0.00227506426598161 0.00288137571929968 1165 2705.36363636364 2563 0.000227739679039367 871 1.50257364998911 1.50257364998911 1 3.54329252710675 1163 3590 4318 2563 4402 1701 871 1934 3863 3755 1599 2552 M13853 GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. 9/23 Gene Ontology BP GO:0048642 0.000178942613016749 0.000255876363485299 2585 2502.18181818182 2564 1.789570238564e-05 1317 1.44335591236121 -1.36665148491324 -1 4.81254983381823 2581 2564 4145 3086 3133 1317 1972 1626 3205 2354 1541 2553 M15523 GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. 229/638 Gene Ontology BP GO:0002683 3.74374391816523e-08 1.59469752404047e-07 3295 2343.36363636364 2564 3.40340361988416e-09 498 1.82198591718501 -1.50347105471276 -1 11.4961381355493 3293 1650 525 2564 986 3695 3413 2928 1950 498 4275 2554 M13290 GO_REGULATION_OF_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of fatty acid transport. 16/57 Gene Ontology BP GO:2000191 1.40936775915609e-05 2.37779596866341e-05 2565 2693.27272727273 2565 1.28125162541171e-06 1608 1.24748936091173 1.4112112657764 1 5.35435798085203 1771 3214 2565 3481 2661 2441 1608 3197 3924 2199 2565 2555 M10676 GO_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 17/35 Gene Ontology BP GO:0051125 3.61304149481342e-07 9.30762314381591e-07 3405 2499.27272727273 2566 3.28458371652756e-08 209 1.04421623894952 -1.27697524186372 -1 5.84602282855227 3404 209 2566 2040 1730 3401 4543 1359 1983 3352 2905 2556 M11058 GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a type 2 immune response. 14/45 Gene Ontology BP GO:0002828 5.44770703138599e-08 2.09558440320838e-07 3690 2519.45454545455 2567 4.95246106025797e-09 1107 2.21476509488934 -2.6722438988116 -1 13.7305649431622 3686 1910 1313 2567 1107 3496 4429 2785 1751 1412 3258 2557 M14920 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 12/24 Gene Ontology BP GO:0042347 8.94107566832346e-06 1.56065467398593e-05 4625 2733.18181818182 2567 8.1282836419837e-07 486 1.34887747627522 -0.642156412496872 -1 6.01849677026125 4622 2696 2389 1775 2567 2507 3768 1637 486 3403 4215 2558 M14362 GO_GOLGI_RIBBON_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_RIBBON_FORMATION.html The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. 7/13 Gene Ontology BP GO:0090161 1.19185874693222e-05 2.03898311054027e-05 1785 2641.63636363636 2569 1.1918651393532e-06 825 0.885749315439728 -0.885749315439728 -1 3.85662206830733 1783 2569 4228 3779 2640 825 1158 1918 4401 4512 1245 2559 M11496 GO_XENOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XENOPHAGY.html The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. 66/157 Gene Ontology BP GO:0098792 1.08223862399101e-06 2.38256706078248e-06 3580 2826.63636363636 2570 9.83853778521264e-08 1511 1.67976254184612 -1.38895764253178 -1 8.76761805184821 3576 3655 1907 4007 2041 1511 4188 2570 1791 3480 2367 2560 M13420 GO_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a protein. 447/1131 Gene Ontology BP GO:0006468 3.69522422606364e-09 4.05601089399846e-08 2575 2355.54545454545 2572 3.35929475660937e-10 145 1.45434072968226 1.64330258237512 1 9.97910139604379 2572 458 2645 1787 145 3444 2593 3381 2514 2456 3916 2561 M13624 GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 10/24 Gene Ontology BP GO:0051043 0.000616468652409814 0.000828441086291973 2860 2629.27272727273 2572 5.60583147956355e-05 1549 1.66136982461866 -1.06742024976122 -1 4.75259938551645 2856 2986 1946 3456 3282 1549 2572 4078 1610 2480 2107 2562 M11889 GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. 257/638 Gene Ontology BP GO:0060627 7.61311624609758e-08 2.64468288916326e-07 4025 2501.90909090909 2573 6.92101500868186e-09 657 1.49446596127544 -1.33147260361946 -1 9.12482118395875 4025 1351 923 1630 1248 2573 4121 4535 2710 657 3748 2563 M12033 GO_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_MEDIATED_IMMUNITY.html Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 29/269 Gene Ontology BP GO:0019724 6.41232630562331e-06 1.15486543975985e-05 2575 2667.63636363636 2575 5.82940454151558e-07 1466 1.70105787284696 -1.15625311733778 -1 7.79637227208112 2575 3474 2025 4437 2490 3527 1912 1466 2875 1851 2712 2564 M15587 GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS.html The process in which any suture between cranial and/or facial bones is generated and organized. 8/20 Gene Ontology BP GO:0097094 0.0161001378316129 0.018977644059959 2900 2848.54545454545 2576 0.00162179878046818 1900 1.58459642052904 -1.76361412483221 -1 2.53256040424666 2900 2291 4429 3780 3893 1900 2576 1992 2467 2149 2957 2565 M10942 GO_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. 23/56 Gene Ontology BP GO:0046632 1.48463473065133e-06 3.14612462547427e-06 4190 3049.45454545455 2579 1.34966884775839e-07 1622 1.47849515850231 -1.20019100263343 -1 7.55139712574905 4189 2230 1874 2474 2122 3639 4378 4017 2579 1622 4420 2566 M16565 GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of establishment of protein localization. 348/851 Gene Ontology BP GO:1904951 1.17018168949382e-07 3.71773113119548e-07 2580 2689.27272727273 2579 1.06380159248716e-08 1381 1.66189402676782 1.99048856495208 1 9.91892616710162 2579 3740 1550 3244 1381 3606 2944 2562 2560 2103 3313 2567 M13277 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. 17/50 Gene Ontology BP GO:0071825 5.96759969828473e-06 1.08486943614471e-05 2740 2765.27272727273 2581 5.42510535066438e-07 1575 1.83617828557606 1.97341409940347 1 8.4619452766748 2739 2518 1575 3138 2472 4419 2757 4360 1607 2252 2581 2568 M11014 GO_ENDOSOME_TO_LYSOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_TO_LYSOSOME_TRANSPORT.html The directed movement of substances from endosomes to lysosomes. 27/55 Gene Ontology BP GO:0008333 9.50413059058984e-06 1.65086712802501e-05 1400 2483.27272727273 2585 8.64015604476953e-07 744 1.02650117358193 -0.946671410642254 -1 4.55684534086858 1400 3515 3024 3288 2585 744 1072 2282 3763 3919 1724 2569 M14160 GO_AMELOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMELOGENESIS.html The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. 8/23 Gene Ontology BP GO:0097186 4.20946797673462e-05 6.53882897824652e-05 2505 2892.18181818182 2585 4.20954771715342e-06 2139 1.34142387140577 1.32810507781836 1 5.21049196193555 2502 2338 4194 2549 2901 2784 2827 4434 2561 2139 2585 2570 M10636 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. 36/89 Gene Ontology BP GO:0032757 7.79142161727169e-07 1.78292609999963e-06 4190 2883 2587 7.0831130696801e-08 1960 1.56590766145297 -1.67139120098651 -1 8.35636720720445 4190 2465 1982 2843 1960 2138 4620 3188 3290 2450 2587 2571 M15143 GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 32/102 Gene Ontology BP GO:0060193 4.93271727482707e-09 4.70279390287928e-08 3180 2414.90909090909 2587 4.48428844171539e-10 228 2.35552856885616 2.07095678909732 1 16.0221900020189 3177 2587 1047 2411 228 4118 3042 3200 1015 1160 4579 2572 M12076 GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 14/34 Gene Ontology BP GO:0072529 2.69556412930687e-05 4.34113917876233e-05 3000 2513.63636363636 2589 2.45054287040549e-06 736 1.83775654543536 -0.72954414711682 -1 7.44187248050967 2997 2658 1880 1622 2787 4515 3986 1439 736 2441 2589 2573 M12732 GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 25/101 Gene Ontology BP GO:0050805 6.01485613557912e-07 1.42702999680602e-06 2075 2531.63636363636 2589 5.46805252732432e-08 1621 1.27247218342325 1.4855268567001 1 6.90468804355872 2071 2589 2555 2620 1882 3363 2071 1621 3053 3151 2872 2574 M15323 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. 5/25 Gene Ontology BP GO:0002689 5.79464071353667e-06 1.05590725404045e-05 3025 2897.63636363636 2591 5.79465582362958e-07 1511 1.45575693161976 -1.24958033678127 -1 6.72467078746975 3022 2249 4386 2591 2486 2478 3078 4477 2572 1511 3024 2575 M16528 GO_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCONEOGENESIS.html Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. 28/84 Gene Ontology BP GO:0006111 9.89305196423221e-06 1.7164962731663e-05 1890 2345.09090909091 2591 8.99372404727446e-07 865 1.55063566655061 2.00816770441802 1 6.85921399684025 1889 3690 2243 3349 2591 2670 1744 866 2890 2999 865 2576 M16689 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. 11/23 Gene Ontology BP GO:0034391 0.0156522729503181 0.0184840873091596 2425 2871.45454545455 2591 0.00143315960870514 1937 0.900033957521347 -0.666616160650463 -1 1.44802865140335 2424 3159 2591 1937 3677 2820 2332 2169 4211 3868 2398 2577 M11988 GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. 47/117 Gene Ontology BP GO:0030004 8.1843284975857e-06 1.44699669586522e-05 3815 2659.90909090909 2592 7.44032631333486e-07 1933 1.52878421604323 -1.32175845700538 -1 6.86781719457122 3814 1945 2092 2592 2538 2689 4262 1933 2747 1990 2657 2578 M14640 GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosyl compound. 194/462 Gene Ontology BP GO:1901657 1.18509422026911e-06 2.58308968072712e-06 1120 2418.09090909091 2592 1.07735896241381e-07 851 1.25915383550091 -1.00789588961354 -1 6.53120744522751 1116 2748 3246 3467 2056 851 1701 2592 2882 4130 1810 2579 M11231 GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS.html The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 49/987 Gene Ontology BP GO:0007606 0.00521418018361486 0.00639953438871896 1250 2607.63636363636 2593 0.000475143579928037 1249 1.99805641021073 1.92969599585361 1 4.0689665281647 1249 4327 1624 3777 3736 2874 1888 1696 2806 2114 2593 2580 M11774 GO_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSPORT.html The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. 17/32 Gene Ontology BP GO:0006862 1.00992028128252e-05 1.75095588722732e-05 3635 2988.45454545455 2593 9.18113561271424e-07 1399 1.18661848706146 1.30261103070756 1 5.23948089583782 3634 1399 2580 2351 2593 4560 3283 3757 1831 2248 4637 2581 M13960 GO_ANDROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 16/68 Gene Ontology BP GO:0008209 1.28499916209765e-09 2.07161496861784e-08 4545 2524.18181818182 2593 1.16818105713473e-10 15 1.98096250920393 -2.52239543225576 -1 14.1291254582471 4543 2432 1778 2593 15 4040 3827 1142 1811 2698 2887 2582 M13071 GO_RESPONSE_TO_SALT_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. 16/30 Gene Ontology BP GO:0009651 8.24079945729513e-07 1.87375278551524e-06 3315 2859 2594 7.49163867650016e-08 1616 1.81313413919473 -1.55817339618243 -1 9.6393570811144 3314 2594 1687 1616 1974 4237 3749 4234 2429 1684 3931 2583 M15215 GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. 6/11 Gene Ontology BP GO:0070525 0.00542245617456919 0.0066463738169284 1745 2697.81818181818 2594 0.000543573315734195 1525 1.08784629205609 -1.08784629205609 -1 2.19876034220065 1743 3331 4370 2594 3874 1525 2348 1942 2849 3453 1647 2584 M16815 GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. 25/91 Gene Ontology BP GO:0045671 3.08843910306134e-06 5.96490131260973e-06 1940 2771.18181818182 2595 2.80767585339247e-07 1936 1.89358577349811 -2.05975189987696 -1 9.18312010069603 3785 2468 1936 3230 2328 2595 4477 1936 2898 2227 2603 2585 M10313 GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. 20/55 Gene Ontology BP GO:0031122 7.14585625286333e-05 0.000107061021561938 1585 2263 2596 6.49644397195732e-06 409 1.38130045867047 -1.07523862185093 -1 5.09082432136317 1582 3927 2596 2614 4148 409 1106 880 3542 3155 934 2586 M11317 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. 69/144 Gene Ontology BP GO:0097191 6.67721031602195e-07 1.56025603911877e-06 3595 2871.72727272727 2596 6.07019303874543e-08 1589 1.45010660606324 -1.23917401076608 -1 7.81639033048641 3591 1589 2378 1896 1912 3031 4264 4130 2260 2596 3942 2587 M14214 GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. 37/71 Gene Ontology BP GO:0043124 6.90744093992263e-08 2.45818630905085e-07 3520 2724.09090909091 2597 6.27949196072613e-09 1206 1.15291149394085 -1.00136358023492 -1 7.07336652134409 3518 1531 2595 2597 1206 3977 2293 2854 1867 2947 4580 2588 M10737 GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN.html Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. 2/16 Gene Ontology BP GO:2000047 0.00920010042889002 0.0110692060874155 2620 2736.7 2598.5 0.00102643759976787 1805 1.74666645914289 -1.74666645914289 -1 3.17118868991696 2620 3335 3627 NA 3825 1805 2406 1880 2774 2577 2518 2589 M11677 GO_REFLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REFLEX.html An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. 8/41 Gene Ontology BP GO:0060004 0.000265555727637528 0.000371938233309515 2430 2617.45454545455 2600 2.65587466905753e-05 1323 1.64396795697475 1.56370054092976 1 5.23355720511834 2430 2600 3788 1323 3194 3275 2359 3237 2262 1520 2804 2590 M14163 GO_RESPONSE_TO_PROGESTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROGESTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. 29/72 Gene Ontology BP GO:0032570 3.68095807944262e-06 6.98434342576709e-06 4215 2786.45454545455 2600 3.3463311257264e-07 1285 1.54115633348633 -1.75356655106906 -1 7.37595325938975 4212 1602 1285 2445 2370 2868 4589 2600 3364 1537 3779 2591 M15713 GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-2 production. 27/66 Gene Ontology BP GO:0032663 1.03324443450752e-05 1.7887225613044e-05 2920 2596.72727272727 2600 9.39317533854276e-07 635 1.83300770579418 1.84797405187827 1 8.07782542624126 2917 1796 1266 2033 2600 3720 2764 4631 1858 635 4344 2592 M12245 GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myeloid cell differentiation. 119/290 Gene Ontology BP GO:0045637 1.20267551338652e-07 3.79880624794047e-07 3795 2602.90909090909 2601 1.0933414355757e-08 823 1.73689558447924 1.80683134417874 1 10.3514631858857 3793 1280 1193 1859 1390 3226 3594 4291 2601 823 4582 2593 M15077 GO_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_RECOGNITION.html The process in which a cell in an organism interprets its surroundings. 64/345 Gene Ontology BP GO:0008037 5.20226818045319e-08 2.02141462392973e-07 2110 2533.72727272727 2601 4.72933482133595e-09 1095 1.60587335298848 1.9738196980255 1 9.97903370141966 2108 3233 1551 3006 1095 3457 2249 2601 3299 2514 2758 2594 M16662 GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. 2/12 Gene Ontology BP GO:0042487 0.000318746402670133 0.000443626962709061 1730 2377.8 2601.5 3.54212852183649e-05 80 5.10187540250646 5.10187540250646 1 15.8792583776397 1728 2672 4599 NA 3989 2614 2641 1159 80 2589 1707 2595 M15986 GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. 4/14 Gene Ontology BP GO:0003417 7.83785283434454e-05 0.000116975733557897 2300 2885.45454545455 2603 7.83812929178464e-06 2095 1.2110718124175 1.2110718124175 1 4.4202002886732 2363 2300 4492 2603 3009 2804 2793 4559 2299 2095 2423 2596 M10055 GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION.html The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. 7/24 Gene Ontology BP GO:0021801 5.10179474098666e-06 9.39985435809567e-06 1440 2050.90909090909 2604 5.10180645376383e-07 325 1.44972484037541 1.44972484037541 1 6.76477148149843 1438 3132 3527 2659 3509 1011 415 1229 2604 2711 325 2597 M16422 GO_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING_BY_RNA.html Any process in which RNA molecules inactivate expression of target genes. 74/163 Gene Ontology BP GO:0031047 1.08700123872465e-05 1.87549117480437e-05 1340 2693.18181818182 2604 9.88187826856572e-07 1030 1.39258269443691 -1.38712066717455 -1 6.11033689584943 1339 4407 3184 4141 2604 1030 2142 1532 3478 3883 1885 2598 M12797 GO_TELENCEPHALON_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_GLIAL_CELL_MIGRATION.html The orderly movement of glial cells through the telencephalon. 7/24 Gene Ontology BP GO:0022030 5.10179474098666e-06 9.39985435809567e-06 1440 2097.09090909091 2605 5.10180645376383e-07 326 1.44972484037541 1.44972484037541 1 6.76477148149843 1439 3133 3962 2660 3510 1012 416 1278 2605 2727 326 2599 M10413 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION.html The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. 3/21 Gene Ontology BP GO:0021843 6.25033178456519e-06 1.13139534018465e-05 2730 1993.90909090909 2606 6.25034936462612e-07 11 4.9732206082726 4.9732206082726 1 22.8346749284242 2727 2606 3581 618 2803 3430 2102 865 11 2844 346 2600 M13441 GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. 20/46 Gene Ontology BP GO:0038034 0.000117326692832156 0.000171035426944961 3220 2815 2606 1.06666318517129e-05 1744 1.39595754906701 1.67056818157542 1 4.8812048283294 3219 1744 2606 2020 3055 4180 3739 2219 2430 2165 3588 2601 M13817 GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. 7/19 Gene Ontology BP GO:1900745 1.40399297116678e-05 2.3695890094974e-05 2610 2508.90909090909 2606 1.40400184162884e-06 1563 2.33839844651817 2.33839844651817 1 10.0399161680325 1563 2339 4137 2607 2686 2216 1836 2606 2777 2736 2095 2602 M12613 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION.html The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. 3/21 Gene Ontology BP GO:0021826 6.25033178456519e-06 1.13139534018465e-05 2730 2027.09090909091 2607 6.25034936462612e-07 12 4.9732206082726 4.9732206082726 1 22.8346749284242 2728 2607 3937 619 2804 3431 2103 859 12 2851 347 2603 M14659 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. 10/28 Gene Ontology BP GO:2000679 1.10494646824065e-05 1.90362391541422e-05 2610 2372.54545454545 2607 1.00450183441415e-06 1340 0.933387833252665 -1.01325269916496 -1 4.08989154758087 1991 1414 2608 1935 2607 1558 2669 3229 3537 3210 1340 2604 M14700 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. 20/46 Gene Ontology BP GO:0097192 0.000117326692832156 0.000171035426944961 3220 2817.18181818182 2607 1.06666318517129e-05 1745 1.39595754906701 1.67056818157542 1 4.8812048283294 3220 1745 2607 2021 3056 4181 3740 2231 2431 2168 3589 2605 M10601 GO_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 68/177 Gene Ontology BP GO:0010921 1.69801492206641e-06 3.52588697815488e-06 3720 2864.81818181818 2608 1.54365112058012e-07 1464 1.51903336216133 -0.921703168010059 -1 7.68865838116613 3718 2124 2171 1464 2160 2608 4208 4126 1713 3016 4205 2606 M12736 GO_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION.html The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 64/184 Gene Ontology BP GO:0042113 1.22324932244923e-07 3.8465050004516e-07 4115 2665.54545454545 2608 1.1120449004224e-08 1397 1.91165850282777 -1.15836025884313 -1 11.3833901096634 4113 3081 1810 1574 1397 1891 4286 2608 1763 2818 3980 2607 M13294 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP.html Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. 4/13 Gene Ontology BP GO:0045188 1.01468288570342e-05 1.75855641594662e-05 3735 2916.54545454545 2609 1.01468751884931e-06 1523 1.94753602142299 -1.19306608944343 -1 8.5958905296691 3733 2342 4046 2745 2609 4218 2515 2327 1523 2081 3943 2608 M11937 GO_CYTOCHROME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 17/27 Gene Ontology BP GO:0017004 1.11888996981265e-05 1.92407634438524e-05 1280 2264.54545454545 2610 1.01717787306802e-06 731 0.682803493024865 -0.709520693704716 -1 2.98894670412003 1280 2783 3270 2922 2610 731 845 1119 4131 4027 1192 2609 M13787 GO_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. 78/260 Gene Ontology BP GO:0050707 8.79831817890734e-08 2.96233439482718e-07 2775 2500.90909090909 2610 7.99847139161166e-09 746 1.68773392565583 1.75388778171353 1 10.2276911001625 2771 2676 1160 2418 1293 4478 2610 2244 3104 746 4010 2610 M15541 GO_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_STORAGE.html The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 18/37 Gene Ontology BP GO:0019915 5.19501789426432e-08 2.02141462392973e-07 4285 2658 2611 4.72274365176184e-09 819 1.67369034253455 -1.24367583887037 -1 10.400454255398 4281 1610 1147 1442 1093 4003 4064 3830 2611 819 4338 2611 M10629 GO_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 31/53 Gene Ontology BP GO:0070670 5.99659010597928e-06 1.08886069073374e-05 3005 2784.63636363636 2612 5.45146041007626e-07 1255 2.2241996813327 -2.04590372550833 -1 10.2468317484627 4336 3002 1255 2326 2474 3044 4443 3002 2106 2031 2612 2612 M12320 GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). 25/43 Gene Ontology BP GO:0006891 3.14431263440726e-07 8.26672908355204e-07 1935 2578.54545454545 2612 2.85846643982081e-08 530 0.767350385144129 -0.686237626107088 -1 4.33268213331497 1931 3517 3316 4338 1695 530 1126 2612 4291 4017 991 2613 M10459 GO_POSITIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEMOPOIESIS.html Any process that activates or increases the frequency, rate or extent of hemopoiesis. 95/254 Gene Ontology BP GO:1903708 4.04821572465911e-07 1.02058478340232e-06 4195 2776.18181818182 2613 3.68019679051881e-08 933 1.70675734110751 -1.46889942079282 -1 9.49185666998029 4194 2416 976 2142 1769 2613 4250 4245 3022 933 3978 2614 M14429 GO_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. 72/179 Gene Ontology BP GO:0006006 8.41659436685381e-05 0.000125010389140442 2595 2308.45454545455 2615 7.65174216348329e-06 490 1.31897946629767 -1.20003116647031 -1 4.77872133891299 2592 2876 2663 2932 3002 490 2615 2252 2962 2207 802 2615 M13776 GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT.html The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. 19/41 Gene Ontology BP GO:0043001 5.86374086480495e-07 1.39688808800869e-06 3760 2548 2616 5.33067493426358e-08 686 1.10261722759628 -1.1604867265617 -1 5.99251062514619 3760 686 2715 2198 1875 2275 3644 3181 1549 3529 2616 2616 M11676 GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION.html Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. 18/49 Gene Ontology BP GO:0097035 1.15078475936727e-05 1.9745357123955e-05 1685 2915.72727272727 2617 1.04617343543826e-06 1683 1.83991699154896 2.07261914351191 1 8.03496641585512 4454 1683 1684 1723 2617 3569 4555 2894 2081 2410 4403 2617 M16383 GO_RECEPTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 12/24 Gene Ontology BP GO:0032801 1.88107707313594e-05 3.10260776219189e-05 1180 1997.54545454545 2617 1.71008468836041e-06 261 1.19561741877658 -1.19561741877658 -1 5.00347319200535 1176 2956 2699 2617 3655 261 997 730 2979 3405 498 2618 M15509 GO_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. 145/300 Gene Ontology BP GO:0030099 1.07668349919578e-08 7.11101207221337e-08 1730 2439.36363636364 2620 9.78803185877352e-10 518 1.47809240424451 1.85411962982676 1 9.80752512173717 1729 3309 2146 2768 518 3749 2333 1647 2620 3230 2784 2619 M12089 GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM.html The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 12/25 Gene Ontology BP GO:0003159 9.52983843411694e-09 6.64962640674653e-08 2625 2232.36363636364 2621 8.66348952308891e-10 464 2.43808805706435 -1.30337313056452 -1 16.2432803099156 2621 3697 1621 1035 464 3819 3043 1514 1052 2796 2894 2620 M11841 GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 6/17 Gene Ontology BP GO:0060218 0.00166390420991736 0.00214418741233592 2600 2586.90909090909 2622 0.000166515138414658 148 2.36898308210647 2.36898308210647 1 5.86863237611064 2598 3379 3815 1637 4033 2931 2392 1480 148 3421 2622 2621 M12351 GO_RESPONSE_TO_TESTOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TESTOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. 24/66 Gene Ontology BP GO:0033574 3.43317789108201e-05 5.42369681806525e-05 2735 2453.27272727273 2622 3.12111951655368e-06 1301 1.67107000706663 -2.00478523004378 -1 6.61689967685663 2731 2622 2159 3207 2842 1452 2342 1301 3076 3049 2205 2622 M15703 GO_ZINC_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. 7/27 Gene Ontology BP GO:0055069 0.00166580158757715 0.0021460368399336 2580 2895.81818181818 2624 0.000166705160927931 1481 1.26669455288915 -0.769041437071476 -1 3.13751563625067 2577 2410 4443 3449 4631 3033 1783 1481 3442 1981 2624 2623 M14195 GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT.html The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. 5/12 Gene Ontology BP GO:0043369 0.00049473495912794 0.000673820597017022 2630 2642.54545454545 2626 4.94845136857632e-05 1037 2.06760305283683 2.06760305283683 1 6.08688286418803 2626 2028 4201 1930 3497 3801 3442 1230 1037 2281 2995 2624 M15834 GO_CYTOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOLYSIS.html The rupture of cell membranes and the loss of cytoplasm. 18/49 Gene Ontology BP GO:0019835 2.29260110316515e-06 4.56455699914057e-06 2705 2603.63636363636 2626 2.08418499297141e-07 1484 1.6252995985572 -1.38543853023544 -1 8.05735913911287 2702 2626 1556 2265 2255 4198 2124 3107 3315 1484 3008 2625 M16577 GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING.html The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. 29/65 Gene Ontology BP GO:0061077 2.25122741744867e-08 1.12118515518463e-07 3115 2568.54545454545 2627 2.04657040044105e-09 801 1.48279298831601 1.52533492521913 1 9.56653408931873 3111 1732 2399 1318 801 3392 4367 3230 2461 2627 2816 2626 M10715 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. 56/147 Gene Ontology BP GO:0070664 1.912618026878e-06 3.89999363144249e-06 3835 3132.72727272727 2628 1.73874517241478e-07 1608 1.63772233083664 -1.47234352588033 -1 8.22282889395914 3834 2125 1608 2520 2196 4006 4274 4395 2628 2258 4616 2627 M15543 GO_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. 93/196 Gene Ontology BP GO:0006643 3.85962868763102e-08 1.62788522131635e-07 4345 2708.18181818182 2628 3.50875341394858e-09 775 1.28827076925015 -1.17899390186055 -1 8.11787178186028 4341 775 2628 2303 997 2439 4494 3544 2721 2157 3391 2628 M16119 GO_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. 61/185 Gene Ontology BP GO:0006766 2.0008000299082e-08 1.0352305921239e-07 4085 2596.27272727273 2628 1.81890913464051e-09 753 1.42504447146354 -1.14231271336342 -1 9.23978049853963 4081 1035 1537 2628 753 2305 4226 3010 2801 1570 4613 2629 M10846 GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 66/144 Gene Ontology BP GO:0071482 9.93600554539559e-07 2.20520429002255e-06 3245 2860.63636363636 2629 9.03273639351123e-08 1829 1.545793184215 2.05223133917484 1 8.11656441497936 3244 2584 1829 2057 2019 3782 4123 3031 2629 2110 4059 2630 M16271 GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 11/27 Gene Ontology BP GO:0042454 3.7493731756155e-06 7.09964912495219e-06 3225 2787.45454545455 2629 3.40852687776316e-07 1810 1.54628727130263 -1.14161300487685 -1 7.39030261883887 3223 2103 1903 2629 2373 4151 3525 2388 1810 2674 3883 2631 M16386 GO_SIGNAL_PEPTIDE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_PEPTIDE_PROCESSING.html The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. 13/30 Gene Ontology BP GO:0006465 0.000179516865070591 0.000256618474298878 1740 2375 2629 1.63210468240535e-05 1071 1.40538630633928 -1.4084478776423 -1 4.6843077955757 1738 2629 2473 2902 3124 1071 1480 3183 2714 2973 1838 2632 M14411 GO_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. 17/46 Gene Ontology BP GO:0097581 1.25183683664931e-05 2.13372923368676e-05 1895 2617.72727272727 2630 1.13803996351569e-06 927 0.938565433033669 -1.00596624691571 -1 4.06940196559886 1893 3520 3047 4325 2630 927 2188 2391 3719 2834 1321 2633 M12992 GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrate derivative. 296/665 Gene Ontology BP GO:1901137 5.33481778754502e-09 4.92436560389096e-08 3525 2501.54545454545 2632 4.84983436407411e-10 252 1.31619778290415 -0.990248986479224 -1 8.92828425485983 3523 463 2397 2810 252 2506 3747 2632 2674 1916 4597 2634 M13316 GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 8/43 Gene Ontology BP GO:2000516 0.000447101147856032 0.000612357117845297 2635 2672.45454545455 2632 4.47191128082629e-05 777 1.8055666853777 1.738663540917 1 5.38508719194439 2632 2407 4051 3337 3254 2561 777 1903 3445 2135 2895 2635 M11643 GO_PEPTIDYL_CYSTEINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_CYSTEINE_MODIFICATION.html The modification of peptidyl-cysteine. 11/37 Gene Ontology BP GO:0018198 0.000925715968828816 0.00122174509473343 2405 2878 2633 8.41914292000355e-05 1167 1.02496058274135 -1.02496058274135 -1 2.77153042519991 2403 3872 2578 3801 4251 1387 2633 2364 3887 3315 1167 2636 M11754 GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. 36/91 Gene Ontology BP GO:1904063 5.38202778833386e-08 2.07547799179685e-07 2930 2570.36363636364 2635 4.89275265454412e-09 1104 1.37613701149209 -1.21230901266981 -1 8.53678986988082 2929 1453 1930 1421 1104 4023 2635 4403 2802 2107 3467 2637 M12800 GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. 20/41 Gene Ontology BP GO:2000272 2.27721888991637e-06 4.53782287806082e-06 3420 2591.45454545455 2635 2.0702011336981e-07 1149 1.3488506112971 -1.09072620209703 -1 6.69006825229132 3418 1149 1859 1314 2253 4547 2868 3177 1934 2635 3352 2638 M12493 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. 14/27 Gene Ontology BP GO:0050687 0.00113569054233029 0.00148493697213166 3360 2675.09090909091 2636 0.000103297930539433 568 1.39084279077 -0.810495052223826 -1 3.65150083006817 3356 3123 2525 2194 3371 1908 2636 3615 568 2442 3688 2639 M12270 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. 56/124 Gene Ontology BP GO:0090317 2.33128029810186e-07 6.44677452298209e-07 2640 2702.18181818182 2637 2.1193459501285e-08 1605 1.21529094235946 -0.76241306756819 -1 6.98370955452245 2637 3030 2683 2486 1611 4443 2317 1605 2907 3486 2519 2640 M14041 GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. 13/47 Gene Ontology BP GO:1903020 0.0372567804284605 0.0425124678125687 2130 2969.90909090909 2639 0.00344573605930822 1581 2.29019039492552 2.29019039492552 1 2.91562285610693 2128 4232 2219 4451 3839 2639 1581 2346 3841 2962 2431 2641 M12354 GO_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS.html Any process that modulates the frequency, rate or extent of hemopoiesis. 187/511 Gene Ontology BP GO:1903706 2.28052672115711e-07 6.31978443322731e-07 4555 2819.63636363636 2641 2.07320632505204e-08 831 1.68426545697631 -1.48965358429659 -1 9.69219558852253 4554 2119 1214 2422 1605 2641 4425 4325 2850 831 4030 2642 M13553 GO_POSITIVE_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINESIS.html Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. 17/66 Gene Ontology BP GO:0032467 0.000346834881220785 0.000480415976583563 2120 2711.09090909091 2641 3.15354156891659e-05 1124 1.61621530270092 -1.61621530270092 -1 4.97845735017243 2119 4297 2641 3658 4341 1346 2108 1138 3273 3777 1124 2643 M15823 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein. 7/25 Gene Ontology BP GO:0042523 0.00147754307072776 0.00191252647822386 2000 2767.81818181818 2641 0.000147852640111736 1747 1.05915283786353 1.16575766389307 1 2.67263661280092 1997 2641 4463 3113 3410 2075 1904 1781 3737 3578 1747 2644 M11092 GO_WHITE_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_WHITE_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. 12/20 Gene Ontology BP GO:0050872 0.00327138690046647 0.00409518721457693 2490 2629.90909090909 2642 0.000297841962218925 931 1.03329302865609 1.09461358877695 1 2.29021964137987 2490 2694 2463 2254 3572 1898 931 2775 3818 3392 2642 2645 M15604 GO_HEME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. 15/21 Gene Ontology BP GO:0006783 1.32516014424158e-05 2.2496228700964e-05 2150 2361.09090909091 2642 1.20469829668332e-06 932 0.92029412481746 -0.679871786628508 -1 3.97055884641821 2146 2008 2967 3216 2642 932 1295 2825 2713 3691 1537 2646 M13909 GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. 5/31 Gene Ontology BP GO:0045624 3.72720488260612e-06 7.06055172172184e-06 2690 2513.45454545455 2644 3.72721113404618e-07 1069 1.8055666853777 1.738663540917 1 8.63351840948273 2690 1824 4154 2644 2394 2560 1069 2665 2983 1506 3159 2647 M10173 GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 7/20 Gene Ontology BP GO:0061000 1.22830215196268e-05 2.09900879336133e-05 4395 2560 2647 1.22830894128329e-06 179 2.41968710880763 2.57917588806818 1 10.5072057920696 4392 1101 3548 1840 2647 3559 3813 1256 179 1954 3871 2648 M14100 GO_REGULATION_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. 592/1431 Gene Ontology BP GO:0032880 7.58720372870588e-08 2.6407336516028e-07 2330 2795.63636363636 2648 7.58720398775137e-09 1277 1.46715956645809 1.75927130591313 1 8.95897930572329 2329 3506 4186 3013 1277 3622 2565 2356 2743 2507 2648 2649 M16158 GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. 61/126 Gene Ontology BP GO:0046467 1.29441650610069e-07 4.00665055855035e-07 4410 2865.54545454545 2648 1.17674234750948e-08 333 1.21517630560925 -1.11395691210096 -1 7.21605125785443 4410 333 2648 2148 1418 3242 4483 3864 2584 2624 3767 2650 M10618 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. 11/24 Gene Ontology BP GO:1901032 2.47334749732198e-06 4.88254780189879e-06 3535 2973.18181818182 2649 2.24850025271315e-07 2137 1.81764239288181 -1.80622099395976 -1 8.96154278000925 3534 2596 2137 3210 2274 4416 2525 2351 2950 2649 4063 2651 M12919 GO_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_PHOSPHORYLATION.html The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 46/99 Gene Ontology BP GO:0006119 0.000609917511825252 0.000820587368126528 575 2459.27272727273 2649 5.54624243733358e-05 572 0.712655753217502 -0.728502041906813 -1 2.04139594965911 572 2649 3432 3312 3415 711 889 2093 4287 4188 1504 2652 M12923 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rac protein signal transduction. 10/20 Gene Ontology BP GO:0035020 2.50310525284391e-08 1.20434380196417e-07 3250 2510.18181818182 2650 2.27555025574874e-09 847 1.52273424409105 -1.86268834348155 -1 9.78030142698416 3248 2667 2184 1379 847 2650 3932 3902 2440 3202 1161 2653 M10314 GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 6/18 Gene Ontology BP GO:0043517 6.32032285720958e-06 1.14228334083395e-05 2120 2812.45454545455 2651 6.32034083319799e-07 2120 1.50063959160498 1.50063959160498 1 6.88443247552954 2120 2574 3565 3392 2507 2803 2651 2495 3211 2521 3098 2654 M16964 GO_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a higher concentration of a chemical. 24/52 Gene Ontology BP GO:0050918 0.000538660169257633 0.000729366919178533 1955 2833.54545454545 2651 4.89811002745479e-05 1955 1.70815805371557 2.00528351388641 1 4.97415327212986 1955 3889 2062 3666 3268 2651 2177 2610 3242 2620 3029 2655 M14047 GO_ACTIVATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_IMMUNE_RESPONSE.html Any process that initiates an immune response. 213/757 Gene Ontology BP GO:0002253 7.42339395859406e-08 2.59734876787884e-07 3790 2820 2652 6.74854019007221e-09 1239 1.62083557288846 -1.25527968606973 -1 9.9082019736361 3786 2455 2368 2950 1239 2652 3941 2476 2415 2890 3848 2656 M15385 GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 15/49 Gene Ontology BP GO:0045923 7.62472678138999e-05 0.000113904782644767 2430 2605.27272727273 2652 6.93181004622017e-06 1916 1.82486817691572 1.92535598044281 1 6.68002135612075 2428 2692 1965 3046 2988 3135 2652 2286 1916 2045 3505 2657 M15949 GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN.html The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. 4/16 Gene Ontology BP GO:0002016 1.93862148310701e-05 3.19185090286024e-05 2745 2410.54545454545 2652 1.93863839545431e-06 264 3.83257846248176 -3.83257846248176 -1 15.9949313091582 2743 3503 4485 2652 3468 2272 1820 688 264 3123 1498 2658 M11624 GO_RESPONSE_TO_MURAMYL_DIPEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MURAMYL_DIPEPTIDE.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. 12/24 Gene Ontology BP GO:0032495 0.0839184282471183 0.0891201423493528 2655 2853.09090909091 2655 0.00793650793650794 1944 1.82520509554069 2.02907536974696 1 1.77901677758527 2076 3990 2033 2005 4524 3304 1944 2807 2652 3394 2655 2659 M13282 GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition. 95/212 Gene Ontology BP GO:1902806 1.36637674536722e-07 4.18454353568565e-07 2070 2779.72727272727 2655 1.24216075475473e-08 1438 1.30285585487154 1.41975845357495 1 7.71389950038315 2068 3742 2655 3896 1438 3810 1842 2107 3014 3587 2418 2660 M14570 GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 15/48 Gene Ontology BP GO:0006509 1.39089956760279e-05 2.35119667354708e-05 3565 2592.18181818182 2657 1.26446214665845e-06 417 1.54201333685112 -0.790711451948683 -1 6.62547971351221 3563 417 1774 1838 2657 4038 4073 2765 854 2607 3928 2661 M12928 GO_PARENTAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARENTAL_BEHAVIOR.html A reproductive behavior in which a parent cares for and rears offspring. 4/16 Gene Ontology BP GO:0060746 1.27087551825843e-05 2.16300404372209e-05 3225 2716.27272727273 2658 1.27088278637755e-06 577 3.07964419319493 -2.33341055335211 -1 13.3357052953793 3225 1766 3981 2196 2658 3227 2455 3579 577 2080 4135 2662 M13927 GO_MATERNAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_BEHAVIOR.html Female behaviors associated with the care and rearing of offspring. 4/16 Gene Ontology BP GO:0042711 1.27087551825843e-05 2.16300404372209e-05 3230 2733.63636363636 2659 1.27088278637755e-06 578 3.07964419319493 -2.33341055335211 -1 13.3357052953793 3226 1767 4158 2197 2659 3228 2456 3581 578 2084 4136 2663 M14572 GO_PERICARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. 13/30 Gene Ontology BP GO:0060039 1.70081422134307e-05 2.83143794539114e-05 3015 2539.81818181818 2662 1.54620670039588e-06 687 2.21290919853244 2.36832344499563 1 9.34227204758301 3013 2662 2017 1348 2705 4616 3229 2066 687 2965 2630 2664 M12698 GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 165/381 Gene Ontology BP GO:0046822 1.07457378217712e-07 3.45276544681548e-07 2350 2785.36363636364 2663 9.76885304239895e-09 1363 1.4400033440738 -1.00400466863102 -1 8.63750590666601 2350 3571 2526 3020 1363 4362 2373 1603 2663 3531 3277 2665 M11873 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE.html A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 12/19 Gene Ontology BP GO:0033539 0.00756731442779224 0.00915690406261124 2510 2824.27272727273 2664 0.000690315424591077 1197 0.770317128394386 -0.748633144256181 -1 1.45745908547092 2508 2664 3031 2875 3953 1197 2467 2478 4127 3896 1871 2666 M13781 GO_CELLULAR_RESPONSE_TO_CHOLESTEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CHOLESTEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. 11/28 Gene Ontology BP GO:0071397 5.71422963753444e-07 1.36758599005528e-06 3920 2760.09090909091 2664 5.19475556521445e-08 1534 2.21511633875618 -2.15979724816447 -1 12.0576589628487 3917 1918 1648 1534 1867 4076 4187 3530 1726 2664 3294 2667 M13871 GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that activates or increases the frequency, rate, or extent of tissue remodeling. 11/31 Gene Ontology BP GO:0034105 0.00539404160757789 0.00661329157221657 2045 2934.54545454545 2665 0.000491573863141416 1552 1.36571933141406 -1.53287736362897 -1 2.76314607848708 2044 3698 2503 3813 3575 1552 2001 4004 4173 2665 2252 2668 M15301 GO_MITOCHONDRION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_MORPHOGENESIS.html The process in which the anatomical structures of a mitochondrion are generated and organized. 16/37 Gene Ontology BP GO:0070584 0.02599955184332 0.0300437827796254 3540 2644.81818181818 2665 0.00239199961863304 384 2.51828684236098 3.22916936768926 1 3.55843453358529 3539 3090 2506 3220 4379 1595 1872 2112 384 3731 2665 2669 M11642 GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 6/27 Gene Ontology BP GO:0034035 1.2060151417879e-07 3.80144487666072e-07 3925 2268.72727272727 2666 1.20601520723917e-08 44 2.32195668936161 -1.71219830369799 -1 13.8376311202473 3923 439 3780 939 1426 2666 3901 2948 44 1075 3815 2670 M10369 GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoclast differentiation. 41/137 Gene Ontology BP GO:0045670 3.49374109232665e-06 6.64268627832622e-06 3495 2759.72727272727 2668 3.17613330965809e-07 1690 1.69985948355073 -1.82687557488657 -1 8.16987418309713 3494 2312 2055 3539 2359 2842 4324 1690 3234 1840 2668 2671 M10903 GO_PHOSPHOLIPID_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 19/34 Gene Ontology BP GO:0046839 7.69292556524259e-07 1.76212399602473e-06 2895 2675.90909090909 2668 6.99357114117644e-08 1363 1.29718853603374 -1.09189393395767 -1 6.92850184008542 2893 3398 2814 2668 1958 1363 2538 3802 2296 3525 2180 2672 M10637 GO_SEROTONIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. 4/21 Gene Ontology BP GO:0042428 3.7696259410641e-09 4.11960463743285e-08 175 2476.27272727273 2669 3.76962594745863e-10 173 2.29542851434649 -1.05336252206746 -1 15.7359114807828 3777 992 3613 1366 173 4345 3974 2669 175 2070 4085 2673 M11467 GO_REGULATION_OF_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXIT_FROM_MITOSIS.html Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. 16/27 Gene Ontology BP GO:0007096 8.49819004377358e-05 0.000126101298731993 1690 2246.27272727273 2670 7.72592575524802e-06 598 1.04282725569896 -1.10180207087446 -1 3.77455678682568 1686 2786 2670 3115 3005 598 990 1528 3812 3725 794 2674 M16195 GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. 16/40 Gene Ontology BP GO:0014072 0.0106225281615315 0.0127212788893451 2000 2910.63636363636 2670 0.000970378874543041 1673 1.85278875774568 2.18265009189681 1 3.25995616081867 2000 4200 2652 3885 4051 2444 1673 2670 2915 3733 1794 2675 M16209 GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. 22/70 Gene Ontology BP GO:2000677 2.62520738206843e-07 7.14837597739653e-07 2830 2684.27272727273 2670 2.38655245029836e-08 1639 1.05648106293694 -1.0395576091711 -1 6.02710483411266 2827 1802 2551 2619 1639 2304 4041 2698 3501 2875 2670 2676 M16790 GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of organelle assembly. 28/66 Gene Ontology BP GO:1902117 0.000130739677194348 0.00018945827753226 1205 2424.72727272727 2672 1.18861315749168e-05 772 1.16809985471796 -1.14866097712521 -1 4.03628860430872 1204 3086 2672 2616 3070 772 1215 3014 3940 3372 1711 2677 M12248 GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. 11/22 Gene Ontology BP GO:0030970 0.0082588579179985 0.00996255581014992 2675 3030.27272727273 2673 0.000753638710794725 1583 0.682688251945748 -0.687147930715149 -1 1.26845521063892 2673 2563 2996 4180 3621 1583 2195 2530 4373 4404 2215 2678 M13808 GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. 40/130 Gene Ontology BP GO:0017158 5.69637455880394e-07 1.36401583685027e-06 2675 2604.54545454545 2674 5.17852366704055e-08 651 1.45805688494696 1.53114546630043 1 7.93825393847257 2674 1529 1569 2774 1865 4262 2894 4479 2627 651 3326 2679 M12668 GO_REGULATION_OF_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of heart morphogenesis. 12/47 Gene Ontology BP GO:2000826 1.18053049026686e-05 2.02183809159314e-05 3065 2696.45454545455 2675 1.07321529554304e-06 1757 1.32270174707151 -1.12634262697056 -1 5.7636500557471 3064 3582 2338 2999 2621 1782 3486 1757 3177 2180 2675 2680 M13530 GO_PHAGOSOME_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_ACIDIFICATION.html Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. 16/30 Gene Ontology BP GO:0090383 3.26090312946896e-05 5.17619597611089e-05 2825 2285.09090909091 2675 2.96450133137625e-06 1021 1.10042261095724 -1.13149476168277 -1 4.37803983584905 1546 2854 2825 2675 2824 1021 1823 1206 3405 3728 1229 2681 M13970 GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of T cell cytokine production. 24/76 Gene Ontology BP GO:0002724 0.0320690609016624 0.0368373700560165 2145 2876.72727272727 2677 0.0029587540666001 1756 1.40648739365656 -1.22257611731617 -1 1.8718311585113 2142 3890 2677 3316 3980 1756 3117 2311 3698 2618 2139 2682 M10600 GO_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. 19/41 Gene Ontology BP GO:0031063 7.43703200476856e-06 1.32553318994781e-05 2835 2682.72727272727 2678 6.76096104140398e-07 1153 1.79920986347291 -1.00651469465592 -1 8.14625448415747 2834 3663 2337 2424 2520 3928 2678 1364 1153 3019 3590 2683 M12323 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of striated muscle contraction. 13/27 Gene Ontology BP GO:0045989 3.0883890526514e-06 5.96490131260973e-06 2535 2643.45454545455 2678 2.80763035289205e-07 1676 1.90042264890753 -1.66650542345352 -1 9.2162761637964 2531 3450 1937 2678 2327 2989 2365 3166 3001 2958 1676 2684 M15726 GO_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 78/292 Gene Ontology BP GO:0006338 7.21495007928846e-06 1.28842358531294e-05 2680 2790 2678 6.55906703726375e-07 1672 2.11293385477843 -1.5717611789481 -1 9.59088499819754 2678 4287 1672 3055 2514 2182 3206 3659 1942 2592 2903 2685 M10671 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. 32/82 Gene Ontology BP GO:0051148 3.04048277125401e-07 8.02556083395814e-07 3425 2754.27272727273 2679 2.76407562860023e-08 720 1.70578084423776 -1.45563505578851 -1 9.65169201264131 3424 2262 1080 2679 1687 4413 3551 4193 2352 720 3936 2686 M12840 GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to another neuron across a synapse. 22/105 Gene Ontology BP GO:0007270 6.91495206631127e-06 1.23839565261284e-05 2135 2743 2679 6.28633981927987e-07 1583 1.35376668699258 1.45021079855859 1 6.16653854928659 2132 3367 2679 4442 2505 3074 1583 2110 3270 2870 2141 2687 M12858 GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 10/38 Gene Ontology BP GO:0051354 0.00212523475697478 0.00270563887486534 4510 3110.45454545455 2679 0.000193390049832822 2017 1.39942904857642 -1.44475249354757 -1 3.33556481543793 4508 2017 2155 2141 3447 3973 4109 2679 2633 2479 4074 2688 M12955 GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. 86/264 Gene Ontology BP GO:1903707 1.67911183832383e-07 4.94096576560838e-07 2680 2530.81818181818 2679 1.52646542407194e-08 1265 1.65940840688344 -1.61009765634035 -1 9.71380416388867 2679 3047 1717 4253 1500 1265 3660 2680 3037 1801 2200 2689 M14679 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of production of a cytokine. 206/572 Gene Ontology BP GO:0001819 5.33472915077977e-08 2.06385358674913e-07 4030 2653.90909090909 2679 4.84975389103672e-09 890 1.68065530332683 -1.44021860288031 -1 10.4296577330248 4029 2080 1041 2334 1100 2958 3672 4565 2679 890 3845 2690 M14161 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 95/262 Gene Ontology BP GO:0071241 5.65656344870544e-09 5.04881982447536e-08 2680 2566.09090909091 2680 5.14233042113582e-10 269 1.78172811079973 2.20115294402528 1 12.0682309430975 2680 3838 991 2213 269 4536 2361 3227 2956 1821 3335 2691 M16891 GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 14/55 Gene Ontology BP GO:0090022 2.04168397150004e-06 4.11923789587169e-06 1960 2555.72727272727 2680 1.85607806023923e-07 1914 1.60838246459012 1.6638075905352 1 8.04005347108322 2599 1958 1956 2680 2224 2904 2683 2782 3441 1914 2972 2692 M13345 GO_REGULATION_OF_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 856/2098 Gene Ontology BP GO:0080134 9.60547733825747e-09 6.67334137483928e-08 2895 2786.45454545455 2681 9.60547737977679e-10 512 1.56007702154505 -1.25702220162297 -1 10.39146607804 2892 2673 4056 3568 512 2676 2964 2681 2526 1716 4387 2693 M12231 GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that modulates the frequency, rate, or extent of immunoglobulin production. 34/86 Gene Ontology BP GO:0002637 0.000468704824717788 0.000640246102137302 2585 2902.54545454545 2683 4.26186100883751e-05 2161 1.39234633098738 -1.21984561959648 -1 4.1276620288144 2582 2683 2498 3427 3250 2161 3397 3418 3378 2680 2454 2694 M13557 GO_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAT_CASCADE.html An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 25/85 Gene Ontology BP GO:0097696 1.74059623083989e-07 5.05968581911612e-07 4550 2923.54545454545 2684 1.58236033504765e-08 1515 1.55329396866376 -1.41940084027717 -1 9.07776603402619 4548 1676 1669 1998 1515 2996 4430 4364 1815 2684 4464 2695 M10468 GO_CELLULAR_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 26/70 Gene Ontology BP GO:0006073 0.002262499836642 0.00286780964824701 1820 2778.54545454545 2685 0.000205893633402141 1817 1.27206714069327 1.54630667558143 1 3.00214395375596 1817 3865 2664 3876 3456 2852 1828 2251 2685 2782 2488 2696 M13587 GO_GOLGI_TO_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_ENDOSOME_TRANSPORT.html The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. 14/27 Gene Ontology BP GO:0006895 1.53983448241408e-05 2.5782371084921e-05 2610 2683.72727272727 2685 1.39985932745688e-06 1579 1.06155646032083 -1.16933210446066 -1 4.52167894368925 2606 2790 2964 3708 2685 1579 2493 2008 2855 3971 1862 2697 M14003 GO_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE.html Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 25/85 Gene Ontology BP GO:0007259 1.74059623083989e-07 5.05968581911612e-07 4550 2924.81818181818 2685 1.58236033504765e-08 1516 1.55329396866376 -1.41940084027717 -1 9.07776603402619 4549 1677 1670 1999 1516 2997 4431 4368 1816 2685 4465 2698 M12331 GO_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 26/70 Gene Ontology BP GO:0044042 0.002262499836642 0.00286780964824701 1820 2778.81818181818 2686 0.000205893633402141 1818 1.27206714069327 1.54630667558143 1 3.00214395375596 1818 3866 2665 3877 3457 2853 1829 2240 2686 2787 2489 2699 M12738 GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. 2/14 Gene Ontology BP GO:0007210 0.00416885363830815 0.00516159665137726 2190 2969 2686 0.000464066458396356 1693 3.09723556134655 3.09723556134655 1 6.57582934757518 2189 3504 3953 NA 3870 2424 2789 1693 4107 2583 2578 2700 M14749 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN.html An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. 15/224 Gene Ontology BP GO:0002455 6.79657717348654e-05 0.000102157681503716 2690 2415.54545454545 2686 6.17889741167902e-06 1127 1.74864337364135 -1.20496640910003 -1 6.47772652335687 2456 2690 1404 3447 2968 3070 2072 1828 2823 1127 2686 2701 M15358 GO_RESPONSE_TO_X_RAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_X_RAY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). 20/37 Gene Ontology BP GO:0010165 5.13309660729856e-05 7.86566585732251e-05 2690 2699 2686 4.66656034358338e-06 818 1.70968990305439 2.60857214161084 1 6.51361098481563 2686 3397 1966 2582 3914 4115 3270 818 1178 2643 3120 2702 M15718 GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of smoothened signaling. 11/42 Gene Ontology BP GO:0045880 0.0839184282471183 0.0891201423493528 2080 2890.72727272727 2686 0.00793650793650794 1092 2.36036295588565 2.36036295588565 1 2.30063208736233 2079 3800 2642 3868 4400 3243 2089 2686 1092 3328 2571 2703 M10422 GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. 19/70 Gene Ontology BP GO:0002820 0.00049713160806867 0.000676687791340614 2765 2638.72727272727 2687 4.52039981735282e-05 1212 2.13395195583582 -2.31620167460299 -1 6.27855670919617 2765 3319 1790 3212 3904 2400 3579 1212 2570 1588 2687 2704 M16622 GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE.html Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. 20/40 Gene Ontology BP GO:0043094 6.5170682314445e-07 1.52899180387048e-06 3335 2928.09090909091 2687 5.92460923818077e-08 1904 0.888194189158855 -1.00354935855566 -1 4.7948076998271 3335 2052 2687 4378 1904 2036 2597 3004 3904 3917 2395 2705 M10232 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. 16/23 Gene Ontology BP GO:0070230 1.83552459015274e-05 3.04152058246937e-05 2635 2729.27272727273 2688 1.66867264059289e-06 1058 3.442058313775 -3.03901622561265 -1 14.4320732349278 2633 3957 1640 2583 2714 4032 2501 3123 1058 2688 3093 2706 M15407 GO_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 479/1446 Gene Ontology BP GO:0009607 1.30822177022366e-09 2.0945081652236e-08 3650 2595.45454545455 2688 1.18929251909235e-10 254 1.7876344082989 -1.5776222093838 -1 12.7423012207881 3646 2542 254 2960 880 2688 3493 4541 2300 842 4404 2707 M15582 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. 12/19 Gene Ontology BP GO:0097296 7.63436608160837e-06 1.35861869363387e-05 3810 2593.81818181818 2688 6.94035688568887e-07 605 1.76552921082062 2.44217969715538 1 7.97621178483632 3809 2279 2047 1181 2526 3409 4373 2803 605 2812 2688 2708 M11465 GO_NEURAL_RETINA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_RETINA_DEVELOPMENT.html The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. 23/87 Gene Ontology BP GO:0003407 4.24061429669785e-09 4.33682206598416e-08 2695 2475.09090909091 2691 3.85510391351987e-10 184 1.38038796262095 1.67059100704763 1 9.43441497563356 2691 1952 2139 2783 184 3783 2265 4112 2737 1278 3302 2709 M16400 GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html The directed movement of proteins from the endoplasmic reticulum. 15/29 Gene Ontology BP GO:0032527 3.61218474882994e-05 5.68521145383642e-05 2170 2737.81818181818 2691 3.2838582352115e-06 850 0.686206165128763 -0.690477490780886 -1 2.70412859895104 2168 2691 3197 3957 2848 850 1787 2347 4331 4620 1320 2710 M13213 GO_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE.html Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. 298/1073 Gene Ontology BP GO:0045087 2.48336479752163e-08 1.2000772967182e-07 3860 2586.09090909091 2692 2.25760438686719e-09 552 1.60988852565101 -1.42524966443296 -1 10.3423840137172 3858 2501 825 2844 842 2687 3627 3953 2692 552 4066 2711 M12734 GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 16/45 Gene Ontology BP GO:0042036 2.05067196107342e-07 5.76348057824691e-07 4325 2798.27272727273 2693 1.86424741111038e-08 1413 2.04435461696781 -1.87499684305962 -1 11.8402886449766 4323 2059 1413 2643 1582 3058 4345 3113 1544 2693 4008 2712 M12930 GO_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 16/81 Gene Ontology BP GO:0002377 2.42013642296623e-08 1.18142693525154e-07 4240 2895.27272727273 2694 2.20012404508112e-09 830 1.331463244157 -0.953488762223971 -1 8.56210770960897 4238 2519 2522 2395 830 3809 3615 1853 2852 2694 4521 2713 M15078 GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. 7/18 Gene Ontology BP GO:1904152 0.0053612948551118 0.0065748790312425 2695 2918.90909090909 2694 0.000537427351282664 1306 0.709099554525541 -0.661148507048974 -1 1.43632717449823 2953 2293 4344 2694 3733 1306 2127 2693 3773 4549 1643 2714 M15857 GO_2_OXOGLUTARATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_OXOGLUTARATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. 11/25 Gene Ontology BP GO:0006103 0.000675114210974739 0.000903069801658229 3805 2920.54545454545 2694 6.13928611260118e-05 2047 1.35932863380014 -1.79835025443804 -1 3.84129791624232 3801 3093 2456 2202 3297 2101 4076 2694 3687 2672 2047 2715 M14441 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION.html The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. 14/26 Gene Ontology BP GO:0015949 0.00183507624691816 0.00235301270766115 1560 2922.27272727273 2695 0.000166964429165225 1560 1.34183922335154 -1.34183922335154 -1 3.2738369474957 1560 4048 2695 4388 3426 1800 2378 2572 4148 3043 2087 2716 M16403 GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. 12/29 Gene Ontology BP GO:0048384 4.83281303024694e-05 7.4399041443755e-05 4335 2649.27272727273 2695 4.39356290683651e-06 1025 2.0802617162341 -3.14402296461624 -1 7.97209220136947 4333 2695 1587 1806 2912 4640 3760 1025 1238 1606 3540 2717 M12186 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. 13/35 Gene Ontology BP GO:0051770 6.66658481675254e-05 0.00010033372221777 2005 2691.81818181818 2696 6.06071530960422e-06 1647 1.04751227974855 1.27126397927942 1 3.8880434298128 2001 3299 2696 3058 2963 2261 1647 2349 3926 3511 1899 2718 M13263 GO_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 8/21 Gene Ontology BP GO:0090140 0.0765897756730953 0.0843068583333764 2455 2755.09090909091 2698 0.00793650793650794 1494 1.13935458613504 -1.00301225735576 -1 1.13602446391501 2453 1494 4039 2816 3983 2255 2145 3015 2487 2921 2698 2719 M14664 GO_CELLULAR_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 46/139 Gene Ontology BP GO:1901655 1.61364656073628e-05 2.69114977783711e-05 1645 2636.09090909091 2700 1.46696217869398e-06 1506 1.58647004261812 1.55342420308702 1 6.73012466939158 1644 3032 1506 3418 2700 3027 2344 2336 3330 2569 3091 2720 M15034 GO_RNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYADENYLATION.html The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. 22/35 Gene Ontology BP GO:0043631 8.67275537460212e-07 1.95949407320086e-06 2880 2683.90909090909 2700 7.88432617594933e-08 1573 0.807977550051481 -0.884898861685268 -1 4.28096253387841 2880 2050 3189 3698 1988 1573 2580 2700 3675 3337 1853 2721 M14844 GO_STEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 8/19 Gene Ontology BP GO:0016127 3.6791167349659e-05 5.77489486154384e-05 2035 2776.09090909091 2701 3.67917764793501e-06 2032 2.16246036179213 -1.82211722765585 -1 8.50795056971501 2032 2288 4302 2436 2875 3050 2244 3400 3066 2143 2701 2722 M15450 GO_CHOLESTEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 8/19 Gene Ontology BP GO:0006707 3.6791167349659e-05 5.77489486154384e-05 2035 2787.09090909091 2702 3.67917764793501e-06 2033 2.16246036179213 -1.82211722765585 -1 8.50795056971501 2033 2289 4408 2437 2876 3051 2245 3403 3067 2147 2702 2723 M16552 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 6/18 Gene Ontology BP GO:0010661 0.00083525257533971 0.0011077057147393 2170 2668.72727272727 2702 8.35566682602148e-05 1112 1.78998026961557 -1.78998026961557 -1 4.91088134774121 2875 2702 4579 2167 3582 2168 3585 1962 1112 3460 1164 2724 M11781 GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 6/28 Gene Ontology BP GO:0030656 1.52944616500249e-05 2.56269164348847e-05 1700 2671 2704 1.52945669152952e-06 1105 1.00910105502798 0.813845749133255 1 4.3007064256986 1698 2937 3804 4019 2704 1292 1105 3217 3910 2529 2166 2725 M16971 GO_BRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). 16/55 Gene Ontology BP GO:0048854 3.03235967642182e-06 5.86390919517973e-06 3765 2810.27272727273 2704 2.75669441460784e-07 911 2.34806110335726 3.0641035912437 1 11.4033045129064 3764 3182 1987 2179 2325 3638 4499 2405 911 2704 3319 2726 M11116 GO_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_PROLIFERATION.html The expansion of a T cell population by cell division. Follows T cell activation. 21/59 Gene Ontology BP GO:0042098 7.12441659806075e-06 1.27323580695905e-05 4570 3024.63636363636 2706 6.47676333606432e-07 1704 1.59111636951379 1.23474113228957 1 7.22989279232414 4568 2978 2557 2706 2512 3566 4204 2342 1704 3667 2467 2727 M15111 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. 5/14 Gene Ontology BP GO:0033033 0.011410333788969 0.0136295805974229 2390 2964.09090909091 2707 0.00114693487849769 1914 1.23080127133292 1.23080127133292 1 2.1313578169009 2387 3880 4356 2707 4142 3067 2218 1914 3674 2285 1975 2728 M16480 GO_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 160/439 Gene Ontology BP GO:0009615 7.65140545019405e-09 5.91432042474856e-08 3530 2673.63636363636 2709 6.95582316073179e-10 374 1.58048088855204 1.91828406899091 1 10.6043058084481 3528 2709 1689 3948 374 3048 3220 2106 2463 1993 4332 2729 M12400 GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY.html The disaggregation of a macromolecular complex into its constituent components. 135/249 Gene Ontology BP GO:0032984 6.72197966559048e-05 0.000101101883988781 1365 2667.72727272727 2710 6.11107732798954e-06 1364 1.01818342591282 -0.780435278863122 -1 3.77605313526019 1364 2710 3348 2184 2965 1534 2431 2540 3414 4087 2768 2730 M14040 GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. 10/27 Gene Ontology BP GO:0016242 1.78279196222409e-05 2.96048035787068e-05 2775 2491.36363636364 2710 1.6207330994733e-06 868 1.07963788175029 -0.760703868493928 -1 4.53852598134334 2774 868 2739 1708 2710 3211 2057 4111 1688 2481 3058 2731 M13217 GO_SPERM_EGG_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_EGG_RECOGNITION.html The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. 18/76 Gene Ontology BP GO:0035036 3.45078717105606e-05 5.44780851248327e-05 1675 2376.27272727273 2713 3.13712845382617e-06 320 1.48840571228253 -1.48840571228253 -1 5.89094620222872 1675 3479 2713 2807 3656 320 629 1928 4201 3840 891 2732 M15754 GO_RESPONSE_TO_MERCURY_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MERCURY_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. 7/20 Gene Ontology BP GO:0046689 1.66505945731262e-05 2.77489987806981e-05 3100 2487.90909090909 2713 1.66507193334767e-06 493 1.92547682859392 -1.21635860045168 -1 8.14447108721178 3098 873 4453 1692 2713 2186 3690 3103 493 2754 2312 2733 M13498 GO_CELLULAR_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. 6/21 Gene Ontology BP GO:0006883 4.41765616832604e-06 8.2242091377457e-06 4170 2750 2715 4.41766495040931e-07 481 1.76255658358263 -2.09761023097743 -1 8.31945958232508 4167 2114 4087 1710 3300 4008 3488 481 1643 2537 2715 2734 M14541 GO_POSITIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WOUND_HEALING.html Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 25/85 Gene Ontology BP GO:0090303 1.86727422303166e-05 3.08642015576219e-05 2720 2830.36363636364 2716 1.69753642901414e-06 1305 1.72289155195341 -1.41413343375082 -1 7.21366694305926 4378 1736 1305 2278 2719 3600 4209 2716 2449 1463 4281 2735 M10564 GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 9/17 Gene Ontology BP GO:0046130 1.76672998352865e-06 3.65223834083861e-06 2725 2666 2717 1.7667313881309e-07 1210 1.62133085743792 -1.08936304393452 -1 8.18342918231104 2722 2565 3604 2717 2200 3615 2665 1925 1210 3063 3040 2736 M13153 GO_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 15/40 Gene Ontology BP GO:0010939 0.000223604905744606 0.000315753521098603 3225 2702.09090909091 2717 2.03297850788324e-05 1324 1.12247538296247 -1.09606709346165 -1 3.64749628145221 3222 1324 2717 2452 3158 1857 3449 3768 3369 2604 1803 2737 M14480 GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 9/17 Gene Ontology BP GO:0006152 1.76672998352865e-06 3.65223834083861e-06 2725 2729.27272727273 2718 1.7667313881309e-07 1211 1.62133085743792 -1.08936304393452 -1 8.18342918231104 2723 2566 4243 2718 2201 3616 2666 1953 1211 3084 3041 2738 M10603 GO_MICROTUBULE_ANCHORING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ANCHORING.html Any process in which a microtubule is maintained in a specific location in a cell. 11/22 Gene Ontology BP GO:0034453 2.7465893781399e-06 5.3694376769278e-06 2720 2531 2720 2.49690255193147e-07 1748 0.947926475137116 -0.923725080785629 -1 4.63724731495124 2720 2154 2921 2728 2301 1748 3051 1820 2958 3310 2130 2739 M11703 GO_ENDOCARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. 7/14 Gene Ontology BP GO:0003157 2.06715657973387e-06 4.16210234158905e-06 4320 2831.36363636364 2720 2.06715850264773e-07 505 2.52665562313388 -1.30337313056452 -1 12.6198135101711 4319 1973 3791 1414 2252 2841 4488 2626 505 2720 4216 2740 M14732 GO_HISTONE_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving an mRNA encoding a histone. 14/31 Gene Ontology BP GO:0008334 1.8720277755397e-05 3.0920757601675e-05 1260 2428.45454545455 2721 1.70185791383667e-06 918 0.756734208483594 -0.756734208483594 -1 3.1678523852983 1259 2927 3143 3637 2721 1031 1452 918 3894 3973 1758 2741 M15692 GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 26/54 Gene Ontology BP GO:0006213 3.98656493492578e-05 6.23009794441616e-05 2990 2868.81818181818 2721 3.62421561482168e-06 2007 1.50578800277081 -0.888567599492335 -1 5.87829160597156 2987 2721 2180 2666 2869 2007 2568 4452 2454 3244 3409 2742 M16176 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition. 25/44 Gene Ontology BP GO:1902808 0.000687712472493505 0.000919656972865019 1845 2842.45454545455 2722 6.25388675625208e-05 1325 1.40820052325398 1.56426959686549 1 3.96907133240357 1842 4165 2366 3965 3298 2715 1924 1325 3096 3849 2722 2743 M16672 GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. 13/37 Gene Ontology BP GO:0032897 4.79546674324566e-06 8.85654418810246e-06 1075 2316.63636363636 2722 4.3595247238479e-07 646 1.01710869147801 0.917197388643084 1 4.77049089562034 1075 2858 2722 2785 2428 1249 646 3498 3657 3523 1042 2744 M14384 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that increases the amount of sodium excreted in urine over a unit of time. 5/17 Gene Ontology BP GO:0035815 0.0351196608849865 0.0402122282340302 1970 2906.18181818182 2724 0.00356873549738586 1969 3.82587783303774 3.82587783303774 1 4.95648972043087 1969 3136 4232 2575 3863 2724 2419 2233 2527 3286 3004 2745 M16900 GO_QUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving quinone. 20/46 Gene Ontology BP GO:1901661 1.58513601778655e-06 3.33022014958504e-06 2885 2776.36363636364 2724 1.44103378173105e-07 2123 0.891912939237154 -0.780758555291767 -1 4.53498775268786 2884 2141 2914 2724 2136 2123 3234 2272 3498 3918 2696 2746 M15058 GO_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. 7/19 Gene Ontology BP GO:0046339 1.75409462525751e-05 2.91595465272847e-05 3185 2831.54545454545 2725 1.75410847122712e-06 880 2.50562213687661 1.78087594586419 1 10.5483127309601 3182 1972 4342 2543 2725 4063 3351 2504 880 1977 3608 2747 M12756 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. 7/28 Gene Ontology BP GO:0032693 1.47534470384876e-06 3.1319495087532e-06 3855 2847.09090909091 2726 1.47534568333857e-07 1022 3.33993047820225 -2.64340773566432 -1 17.0647372605865 3853 1878 3955 1694 2142 2295 2748 4497 1022 2726 4508 2748 M15970 GO_RESPONSE_TO_COBALT_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COBALT_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. 9/17 Gene Ontology BP GO:0032025 8.36876656380517e-06 1.47517779634576e-05 4100 2888.81818181818 2726 8.36879808028642e-07 1263 1.44061178864571 -0.805917503092444 -1 6.4605147318471 4097 1335 4489 1641 2577 2726 2892 3840 1263 2365 4552 2749 M11152 GO_RESPONSE_TO_MORPHINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MORPHINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. 16/40 Gene Ontology BP GO:0043278 0.0106225281615315 0.0127212788893451 2000 2914.18181818182 2727 0.000970378874543041 1672 1.85278875774568 2.18265009189681 1 3.25995616081867 1999 4199 2651 3884 4050 2443 1672 2727 2914 3724 1793 2750 M16136 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT.html The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 27/55 Gene Ontology BP GO:1901264 3.02420689284862e-07 7.98714027502624e-07 3735 2914 2727 2.74927937142557e-08 1686 1.33984439802707 -1.05594700936199 -1 7.58373319495889 3735 2385 2521 3323 1686 2714 3199 3849 2727 2436 3479 2751 M16688 GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. 71/187 Gene Ontology BP GO:0034111 4.75541849398295e-06 8.78957327530367e-06 3655 2881.90909090909 2727 4.32311706646115e-07 828 1.80564693676915 -1.68712714804949 -1 8.47445541513218 3653 2678 828 2727 2426 3930 3872 3901 2313 1043 4330 2752 M11258 GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 22/46 Gene Ontology BP GO:1900739 0.000254172920164369 0.000356533192846878 2380 3102 2728 2.310929911927e-05 2376 1.56986175382232 2.00418784242294 1 5.02441147728058 2376 4340 2634 3834 3176 3497 2422 2485 2667 3963 2728 2753 M12815 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that stops or decreases the rate or extent of glial cell proliferation. 7/16 Gene Ontology BP GO:0060253 4.3235197078902e-05 6.70030106933718e-05 2990 2610.81818181818 2728 4.32360382789559e-06 1497 0.959441883691492 -0.738889615426855 -1 3.71732406198751 2986 1497 3964 2018 2908 1883 2962 2239 2385 2728 3149 2754 M11661 GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 22/46 Gene Ontology BP GO:1900740 0.000254172920164369 0.000356533192846878 2380 3103.09090909091 2729 2.310929911927e-05 2377 1.56986175382232 2.00418784242294 1 5.02441147728058 2377 4341 2635 3835 3177 3498 2423 2487 2668 3964 2729 2755 M13937 GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. 20/66 Gene Ontology BP GO:0002228 1.17035676308287e-07 3.71773113119548e-07 3165 2665.63636363636 2729 1.06396075031233e-08 1382 1.00534996069196 -0.638466168963528 -1 6.00037772428945 3450 2005 2729 1818 1382 4585 2594 1667 2765 3164 3163 2756 M13351 GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY.html A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. 7/24 Gene Ontology BP GO:0007597 1.75172715067457e-06 3.62768472818111e-06 4060 2830.09090909091 2731 1.75172853152271e-07 351 2.47637693953587 2.47637693953587 1 12.5058829743314 2170 4060 4058 3463 3955 2537 2449 351 3056 2731 2301 2757 M14712 GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT.html The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. 6/16 Gene Ontology BP GO:0072531 0.00106078470668451 0.00139130604325881 3105 2730.54545454545 2731 0.00010612914160276 188 2.0080250567857 2.43021567227624 1 5.32456629169799 3104 1932 4279 2077 3372 3962 2731 3600 188 2546 2245 2758 M11076 GO_MACROMOLECULE_DEACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_DEACYLATION.html The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. 35/70 Gene Ontology BP GO:0098732 0.000850487531718735 0.00112758812386353 2175 2435.27272727273 2732 7.73469541547436e-05 757 0.905744989257338 -0.834866889787597 -1 2.47845110115863 2174 939 3162 2975 3502 757 2535 2732 3367 3496 1149 2759 M11543 GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 14/32 Gene Ontology BP GO:0046131 0.00163616382024124 0.00211019683816113 1315 2507.72727272727 2733 0.000148852901950875 877 0.941779334117386 -0.941779334117386 -1 2.33911703285041 1312 2826 2733 4435 3411 877 1014 2103 3740 3608 1526 2760 M12810 GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION.html Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 11/20 Gene Ontology BP GO:0090129 0.00213813980034488 0.00271759734273235 2765 2652.90909090909 2734 0.000194565513743249 1338 1.69074255688776 1.51414502757233 1 4.02691002168147 2763 2734 2330 2127 4115 2812 1338 1510 2176 3318 3959 2761 M13198 GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 14/28 Gene Ontology BP GO:0009218 0.00163616382024124 0.00211019683816113 1315 2519.63636363636 2734 0.000148852901950875 878 0.941779334117386 -0.941779334117386 -1 2.33911703285041 1313 2827 2734 4436 3412 878 1015 2221 3741 3612 1527 2762 M16218 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. 364/1067 Gene Ontology BP GO:0000122 9.16801810183554e-09 6.53424683264709e-08 3035 2669.90909090909 2734 8.33456194549203e-10 447 1.4303863225099 -1.1545875210698 -1 9.53975969173569 3032 1648 2106 3695 447 3654 2734 3143 2559 1806 4545 2763 M12935 GO_LEFT_RIGHT_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). 9/20 Gene Ontology BP GO:0070986 7.47640654975477e-07 1.72187279814045e-06 2060 2448.45454545455 2735 7.47640906510543e-08 280 2.91714152543922 2.91714152543922 1 15.6081175759107 2056 3904 3983 2821 3823 2735 2094 280 773 3078 1386 2764 M11908 GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). 13/31 Gene Ontology BP GO:1901071 0.0839184282471183 0.0891201423493528 2410 2926.72727272727 2736 0.00793650793650794 1645 1.42320177538723 1.65829867632116 1 1.38718643758412 2409 2064 2247 2267 4338 3965 3490 2736 1645 3509 3524 2765 M12757 GO_PHAGOSOME_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_MATURATION.html A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. 29/49 Gene Ontology BP GO:0090382 2.3084618767127e-06 4.59023061823428e-06 2740 2708 2736 2.09860390817025e-07 1618 1.12078844407197 -0.998958292565119 -1 5.55373054007516 2736 2421 2747 3261 2260 1618 3544 2310 3346 3767 1778 2766 M14155 GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. 38/102 Gene Ontology BP GO:0035305 2.04986352307609e-05 3.36307997796547e-05 2600 2586.54545454545 2736 1.86352965732238e-06 1007 1.35322494373853 -1.29988679808948 -1 5.61905825608495 2596 3887 2756 3407 2736 1183 2729 1198 3323 3630 1007 2767 M11977 GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS.html The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. 9/17 Gene Ontology BP GO:0016973 1.86488810943185e-05 3.08357389319519e-05 1825 2642.45454545455 2737 1.86490375975117e-06 1060 0.931353542975141 -0.931353542975141 -1 3.89988036111088 1824 1873 3837 3152 2737 1060 1698 3636 3787 3744 1719 2768 M13916 GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. 7/24 Gene Ontology BP GO:0055098 0.00188225522176785 0.00240951502472239 1850 2733.45454545455 2737 0.000188385142304395 822 1.79639482046946 1.79639482046946 1 4.36568332850159 1850 2568 4156 2828 3702 2023 822 3519 3668 2737 2195 2769 M11207 GO_PROTEASOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ASSEMBLY.html The aggregation, arrangement and bonding together of a mature, active proteasome complex. 10/17 Gene Ontology BP GO:0043248 0.0136072323055415 0.0161375171378363 2160 2752.18181818182 2738 0.00124473913968107 1685 0.752360513517792 -0.880375549488539 -1 1.25162042376185 2159 2738 3155 2882 4057 1685 2562 2065 3302 3795 1874 2770 M12346 GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. 61/127 Gene Ontology BP GO:0006892 2.90746004978539e-08 1.34723922267002e-07 2900 2502.81818181818 2738 2.643145534736e-09 888 1.01829710497673 -1.04460038858532 -1 6.49434679564404 2899 1591 3263 2738 888 1266 3071 2582 3147 4033 2053 2771 M14063 GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of smoothened signaling. 27/92 Gene Ontology BP GO:0008589 0.00950150343645363 0.0114140958487592 1715 2840.90909090909 2738 0.000867526272286866 1714 1.48800590667077 1.70725389311345 1 2.68316800998563 1714 3236 2738 3579 3632 2949 2217 2602 2599 3306 2678 2772 M12673 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that modulates the frequency, rate or extent of protein localization to the cell surface. 21/46 Gene Ontology BP GO:2000008 2.01736058320488e-06 4.08130945003061e-06 3210 2720.27272727273 2739 1.83396584826433e-07 1465 1.6291989951981 -1.20727030870412 -1 8.15018758057497 3207 1465 1942 2739 2217 4128 3299 4536 1553 1828 3009 2773 M13511 GO_NEURONAL_ION_CHANNEL_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ION_CHANNEL_CLUSTERING.html The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. 4/29 Gene Ontology BP GO:0045161 0.0235606764144053 0.0273754305785996 2635 2837.18181818182 2740 0.00238142661584347 2070 1.76686016263474 -1.50510212232629 -1 2.56288994441546 2635 2077 4090 3198 3811 2740 2322 3380 2804 2082 2070 2774 M14112 GO_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. 7/25 Gene Ontology BP GO:0019433 0.00915118859926369 0.0110160665456006 1365 2847.27272727273 2740 0.000918909338496109 1365 3.00464602543328 3.00464602543328 1 5.46096307357123 1365 3536 4189 3338 3694 2126 2331 1856 4122 2740 2023 2775 M16039 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 12/31 Gene Ontology BP GO:1902176 2.11684815042819e-05 3.46807549839029e-05 3275 2526.18181818182 2740 1.924425926449e-06 626 1.18145357294808 -1.00006613137351 -1 4.89116170207057 3273 706 2618 626 2740 4054 3367 2399 1208 2813 3984 2776 M15178 GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. 20/54 Gene Ontology BP GO:0032727 6.17105146291572e-07 1.45886924349886e-06 4040 3046.72727272727 2741 5.6100483581007e-08 1889 1.12749080837244 -1.19090671973005 -1 6.10796026289333 4037 2390 2727 3166 1889 2725 4197 2741 3374 3605 2663 2777 M16042 GO_MULTICELLULAR_ORGANISM_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_REPRODUCTION.html The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. 355/1283 Gene Ontology BP GO:0032504 1.97734407809179e-08 1.02808606434269e-07 2495 2758.54545454545 2742 1.79758554169456e-09 746 1.6440545493766 1.7239997883366 1 10.6643998922565 2495 4116 1350 3275 746 3815 2742 3687 2719 1705 3694 2778 M16855 GO_STEROID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 13/65 Gene Ontology BP GO:0006706 6.6387257068665e-06 1.19222738442811e-05 3425 2979.54545454545 2742 6.03522339998822e-07 1195 2.04224509264213 -2.23530442235206 -1 9.33390476030201 3423 2394 1195 2847 2498 4090 2573 4415 2742 2322 4276 2779 M10305 GO_URETER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_URETER_DEVELOPMENT.html The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. 6/21 Gene Ontology BP GO:0072189 1.30429928113972e-07 4.03057328094786e-07 3565 2431.27272727273 2744 1.30429935769357e-08 662 1.76001699062254 2.08783392216003 1 10.4472414224453 3023 730 3564 1489 1455 3564 2744 4215 1714 662 3584 2780 M12409 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 16/44 Gene Ontology BP GO:0033144 2.21881368422578e-07 6.17623017737429e-07 2745 2708.63636363636 2745 2.01710355273149e-08 1165 1.08694841506986 -1.14488850938646 -1 6.26497097211938 2745 1165 2393 3262 1597 3426 1735 4396 3738 2197 3141 2781 M10446 GO_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 698/1714 Gene Ontology BP GO:0044248 1.12542152433349e-06 2.46827214807766e-06 2750 2924.45454545455 2746 1.12542209429202e-07 209 1.45146713843545 -1.13879735999551 -1 7.55533810812751 2746 4525 3586 4590 2071 209 2607 3865 2655 4207 1108 2782 M12406 GO_COMPLEMENT_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION.html Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 16/240 Gene Ontology BP GO:0006956 2.17196794574145e-05 3.55086168030899e-05 1905 2418.90909090909 2746 1.97453580815322e-06 1187 1.88851999926412 2.29232033818267 1 7.80042303982409 1901 2983 1187 3621 2746 2824 2173 1941 3213 1264 2755 2783 M12626 GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that reduces the force with which blood travels through the systemic arterial circulatory system. 6/15 Gene Ontology BP GO:0003085 0.00100391385608481 0.00131932409674548 3035 2970.63636363636 2746 0.000100436767401801 1723 2.84610468046634 2.00034233298538 1 7.60780689162799 3034 2670 3940 2561 3368 4204 2746 4076 1944 1723 2411 2784 M12835 GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. 12/27 Gene Ontology BP GO:2000369 2.17892187687191e-05 3.5609765133109e-05 3135 2952.36363636364 2747 1.98085768875288e-06 1813 0.863914849032619 -0.875785342597378 -1 3.56735971851625 3132 1962 2633 2471 2747 2385 4158 4095 3681 3399 1813 2785 M15091 GO_PROTEIN_LOCALIZATION_TO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_SYNAPSE.html Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 7/20 Gene Ontology BP GO:0035418 0.000108595879129684 0.000159006832796948 3090 2720.90909090909 2748 1.08601186373939e-05 1316 1.27770077347313 -1.32987314726819 -1 4.50526186667638 3090 2074 4349 1497 3060 2712 3216 4320 1316 2748 1548 2786 M15534 GO_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERAD_PATHWAY.html The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. 44/99 Gene Ontology BP GO:0036503 6.76643593064888e-08 2.42411744027799e-07 810 2117.81818181818 2749 6.15130558069178e-09 23 0.860759317137724 -0.882866431536456 -1 5.2857912682648 807 2749 3288 3293 3104 23 509 1293 3947 4127 156 2787 M16885 GO_LACTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATION.html The secretion of milk by the mammary gland. 23/88 Gene Ontology BP GO:0007595 1.43199546938744e-07 4.33454996891125e-07 2750 2455.72727272727 2749 1.3018141478155e-08 684 2.01198895856409 -2.41620156621498 -1 11.8839405977722 4134 684 1449 2867 1453 2749 3798 2605 2750 1628 2896 2788 M12148 GO_POLYSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 12/33 Gene Ontology BP GO:0000272 0.0200793364985727 0.0234242108951943 2460 2743.27272727273 2750 0.00184227058749459 1039 1.48152582736301 1.94516229947859 1 2.24210109034392 2458 3583 2457 2983 3767 3216 2750 2041 1039 3396 2486 2789 M13627 GO_ORGAN_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_INDUCTION.html The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. 5/25 Gene Ontology BP GO:0001759 2.49380007921777e-06 4.92083033056018e-06 1080 2195.18181818182 2750 2.49380287778966e-07 107 2.28835566352079 2.28835566352079 1 11.2751007764474 1077 3167 4108 2750 3317 729 107 1384 3143 3280 1085 2790 M15557 GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. 7/31 Gene Ontology BP GO:2001026 0.00949659433216741 0.0114111510052415 1870 2935.72727272727 2751 0.000953742350120922 1631 1.37707686547436 1.37707686547436 1 2.48328431179311 1866 3535 4422 3232 3637 2449 1631 2481 3892 2751 2397 2791 M12491 GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 18/41 Gene Ontology BP GO:0035710 2.53263640008041e-06 4.98686632975969e-06 3240 2786.45454545455 2753 2.30239937786545e-07 1809 1.41329864327759 -1.29639600832041 -1 6.95595727548813 3239 1809 2093 3865 2281 2465 3277 3682 2775 2412 2753 2792 M13207 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS.html Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 19/38 Gene Ontology BP GO:0036003 1.66614399535863e-05 2.77571100482602e-05 2820 2658.54545454545 2754 1.51468783076093e-06 1616 1.72346437314021 1.93104303548276 1 7.28978635916582 2819 2754 1901 1717 2702 4482 3157 1616 1886 3024 3186 2793 M13359 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. 87/215 Gene Ontology BP GO:0051092 2.25246302498255e-05 3.67340562872989e-05 4340 2947.36363636364 2754 2.04771462462217e-06 1739 1.47128197455572 -1.32982221079356 -1 6.05692115378492 4337 2997 2194 2346 2754 1739 4547 4142 3033 1839 2493 2794 M10779 GO_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. 8/21 Gene Ontology BP GO:0043501 2.05948342520936e-05 3.37766921343945e-05 3370 2566.18181818182 2755 2.05950251208222e-06 456 3.87176196278639 -2.37047946378468 -1 16.070139462047 3366 2406 3632 949 2755 4255 2961 2695 456 1514 3239 2795 M11687 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 14/47 Gene Ontology BP GO:0048147 9.02711091473591e-06 1.57448820349808e-05 3680 2817.90909090909 2755 8.2064981411647e-07 469 1.72846360628328 2.17902385330118 1 7.70600614727672 3677 2755 2116 1788 2571 4224 4351 1809 469 3040 4197 2796 M13476 GO_DETOXIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETOXIFICATION.html Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. 35/97 Gene Ontology BP GO:0098754 6.24333974395571e-08 2.30162001994041e-07 2755 2425 2755 5.67576356466755e-09 1163 1.64158663448875 -1.39969137060574 -1 10.1150489552561 2755 1375 1316 2900 1163 2044 3781 4093 2788 1695 2765 2797 M13383 GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. 6/24 Gene Ontology BP GO:0031954 3.24808218531076e-06 6.24207184867462e-06 2505 2698.90909090909 2756 3.24808693283757e-07 1226 0.939995622759808 1.24544198623082 1 4.5413843148431 2505 2867 4065 3296 2363 2756 1315 1226 3820 3436 2039 2798 M15030 GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. 17/44 Gene Ontology BP GO:0031062 4.22422583240859e-06 7.89576511267033e-06 2595 2512.90909090909 2757 3.84021267579783e-07 469 0.963792267797267 -1.10518784601762 -1 4.5650398946939 2593 2888 2844 3176 2399 822 2463 2757 3870 3361 469 2799 M14189 GO_DRUG_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORT.html The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/52 Gene Ontology BP GO:0015893 2.2877844627216e-05 3.72577455644209e-05 4610 2789.45454545455 2758 2.0798256852591e-06 1180 2.03433263354878 -1.81782573870483 -1 8.36325888925042 4609 2521 1691 1625 2758 3593 4178 2975 1180 1904 3650 2800 M16786 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. 12/19 Gene Ontology BP GO:1990440 5.65451492043061e-06 1.03321183689726e-05 3360 2763.63636363636 2760 5.14048132173611e-07 710 1.76080299500387 2.2869389728061 1 8.14921317362415 3360 2760 2128 2378 2461 4134 4155 710 1035 3407 3872 2801 M11986 GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 11/36 Gene Ontology BP GO:0051973 8.6514217481111e-05 0.000128211143238046 2765 2600.72727272727 2761 7.86523816447783e-06 1046 1.26144817569313 -1.58520807873797 -1 4.55742625681159 2761 3613 2880 3727 3010 1186 2060 1046 2707 3856 1762 2802 M11972 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. 55/145 Gene Ontology BP GO:0002718 0.000378169613144455 0.000521795397869154 4185 3128.72727272727 2762 3.43849667603289e-05 1743 1.8372025972597 -1.23720018447397 -1 5.59797403262289 4183 3950 1743 2762 3225 2660 4517 2640 2531 2563 3642 2803 M14293 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. 20/60 Gene Ontology BP GO:0032753 0.000556562865683644 0.000752729794747789 2770 2597.63636363636 2762 5.06094287802629e-05 1699 1.60511713417335 -1.52353610421787 -1 4.65369613326736 2770 1955 1699 2449 3272 2588 3663 2762 2920 1711 2785 2804 M16272 GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. 9/30 Gene Ontology BP GO:0032332 9.04997049595985e-05 0.000133861143716921 3130 2971.09090909091 2762 9.05033907593265e-06 1901 1.62147650930717 -1.62052474340061 -1 5.82996600544099 3129 2762 4539 2609 3028 1901 4135 2571 3411 2369 2228 2805 M16829 GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). 7/71 Gene Ontology BP GO:0030520 0.000126745195218756 0.000184014365666256 3515 2896.09090909091 2762 1.26752424754122e-05 1215 1.63173695879885 -2.41734543309126 -1 5.65753335799376 3514 2640 4623 2649 3084 3229 4383 1522 1215 2762 2236 2806 M13813 GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. 8/19 Gene Ontology BP GO:0060575 0.000276212154052355 0.00038616471883923 2765 2603.63636363636 2764 2.76246491978711e-05 1525 2.2224584813134 1.96439866342772 1 7.04154583225943 2764 2796 4135 1658 3203 2871 2181 2085 1580 1525 3842 2807 M12876 GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-8 production. 44/109 Gene Ontology BP GO:0032677 3.08602132262559e-07 8.13588282143129e-07 3865 2859.18181818182 2765 2.8054743231939e-08 1689 1.4452430716773 -1.55227430885888 -1 8.16955611115786 3861 2880 2241 3430 1689 1764 4468 2611 3401 2765 2341 2808 M14173 GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 7/18 Gene Ontology BP GO:0070498 0.00484651852733413 0.00596753052744543 2715 3206.81818181818 2765 0.000485712101959966 2571 0.867313022956234 -0.960508744272579 -1 1.79068766273085 2711 2765 4197 2571 3574 2630 4087 2667 3758 3565 2750 2809 M11455 GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 18/28 Gene Ontology BP GO:0033014 2.36077153678063e-05 3.83387976399877e-05 2280 2628.63636363636 2766 2.14617897280048e-06 1026 0.92029412481746 -0.679871786628508 -1 3.77277047403292 2278 3399 3123 3475 2766 1026 1610 2718 2941 3838 1741 2810 M11093 GO_OOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOGENESIS.html The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. 35/107 Gene Ontology BP GO:0048477 2.43204055071646e-05 3.94272495704488e-05 4120 2689.81818181818 2769 2.21097039698514e-06 1547 1.88552434030686 -2.13842382238895 -1 7.7084782856581 4119 3146 1762 1925 2769 2860 4537 1993 1547 1694 3236 2811 M14671 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition. 63/135 Gene Ontology BP GO:1902807 6.88444246967213e-07 1.60303241658414e-06 2850 2788.18181818182 2769 6.25858602183288e-08 1919 1.47054170715793 1.5887744288871 1 7.91050558621055 2676 3510 2413 3157 1919 4454 2846 1971 2108 2769 2847 2812 M12875 GO_ENDOCRINE_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. 20/51 Gene Ontology BP GO:0031018 2.44397419584448e-05 3.95792542424344e-05 3495 2655.18181818182 2771 2.22181940573782e-06 899 1.89820296856793 2.34177289810694 1 7.7573670152503 3491 3005 1815 2491 2771 4344 3662 1722 899 1709 3298 2813 M15049 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. 39/76 Gene Ontology BP GO:0072332 1.65414832759089e-06 3.453332142538e-06 3065 2792.63636363636 2771 1.50377233756592e-07 1887 1.4028099156712 -0.998881516703626 -1 7.11214660707866 3065 2771 2480 2529 2151 4538 2822 1887 2208 3380 2888 2814 M15948 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of lamellipodium organization. 21/46 Gene Ontology BP GO:1902745 2.19191243004989e-06 4.3866592296214e-06 3290 2608.27272727273 2774 1.99264964900684e-07 1235 1.76609818609083 -1.48889227411304 -1 8.78366639031982 3289 1235 1747 1427 2243 3986 2837 3269 1527 2774 4357 2815 M13869 GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 53/131 Gene Ontology BP GO:0042345 4.98888275139795e-07 1.21084070124102e-06 2075 2628.72727272727 2775 4.5353489842857e-08 914 1.25902993202061 -1.04778215981959 -1 6.9151302927067 2075 3289 2775 3536 1839 914 2751 3527 2904 3593 1713 2816 M16069 GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that modulates the frequency, rate or extent of the viral entry into the host cell. 21/69 Gene Ontology BP GO:0046596 2.40729890224309e-05 3.90534199969066e-05 3495 2937.81818181818 2775 2.18847749450521e-06 1939 1.49286199620313 0.904893730250695 1 6.10891333905178 3495 2389 2001 3030 2768 4191 2260 1939 3031 2775 4437 2817 M15736 GO_HEXOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 87/228 Gene Ontology BP GO:0019318 1.78109646580388e-05 2.95872303782734e-05 2835 2683.81818181818 2776 1.61919171412161e-06 783 1.26088775413133 -1.15448731184404 -1 5.30075669007443 2835 3441 2776 3967 2709 783 2675 2566 3370 2781 1619 2818 M14542 GO_ICOSANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. 39/162 Gene Ontology BP GO:0006690 2.55191284263143e-05 4.12122828811747e-05 2125 2871.90909090909 2777 2.31994767662739e-06 1708 1.63458969568633 1.46498357921231 1 6.65341850625918 2121 2716 1824 4478 2777 3131 1708 4138 3009 1999 3690 2819 M11709 GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glutathione derivative. 13/28 Gene Ontology BP GO:1901687 1.59744437017187e-05 2.66700259284717e-05 2300 2855.45454545455 2778 1.45223269955482e-06 2150 1.03346149478725 -0.989377297262798 -1 4.38790642160736 2298 2150 2778 2872 2695 2176 2886 3619 3708 3504 2724 2820 M16181 GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acid derivative. 39/162 Gene Ontology BP GO:1901568 2.55191284263143e-05 4.12122828811747e-05 2125 2871.45454545455 2778 2.31994767662739e-06 1709 1.63458969568633 1.46498357921231 1 6.65341850625918 2122 2717 1825 4479 2778 3132 1709 4122 3010 2001 3691 2821 M16920 GO_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. 54/127 Gene Ontology BP GO:0007030 2.55777386276998e-07 6.98573179108295e-07 2605 2749.18181818182 2778 2.3252492364937e-08 627 0.908990100036511 -0.860818884744153 -1 5.1941195307561 2604 3602 3400 4353 1634 627 2778 2024 3999 4136 1084 2822 M11212 GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. 30/66 Gene Ontology BP GO:0045806 0.00102952685790359 0.00135107213149982 2795 2661.27272727273 2779 9.3637178011293e-05 1711 1.29512037097234 -1.33806146049923 -1 3.44951833876301 2793 2779 2614 2838 3355 1788 2957 1711 3500 2707 2232 2823 M12005 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 45/100 Gene Ontology BP GO:0010595 2.68621128050296e-07 7.26387826172116e-07 2990 2625.90909090909 2779 2.44201055317344e-08 713 1.69906024157855 1.55601732676797 1 9.68196747600169 2990 2585 1003 1535 1653 4145 2981 3910 2779 713 4591 2824 M12449 GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione derivative. 13/28 Gene Ontology BP GO:1901685 1.59744437017187e-05 2.66700259284717e-05 2300 2856.54545454545 2779 1.45223269955482e-06 2151 1.03346149478725 -0.989377297262798 -1 4.38790642160736 2299 2151 2779 2873 2696 2177 2887 3614 3709 3512 2725 2825 M12551 GO_VESICLE_CYTOSKELETAL_TRAFFICKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_CYTOSKELETAL_TRAFFICKING.html The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. 30/56 Gene Ontology BP GO:0099518 1.86031339493761e-07 5.34665825958576e-07 2780 2453.36363636364 2779 1.6911941384047e-08 1428 1.00025489994379 -1.1143423201877 -1 5.82344739537523 2779 1731 2791 3043 1541 1428 3564 1464 3720 3144 1782 2826 M10522 GO_RESPONSE_TO_MUSCLE_STRETCH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_STRETCH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. 12/33 Gene Ontology BP GO:0035994 0.00724311689735938 0.00877604168957192 2520 2796.90909090909 2780 0.000660643099663915 1714 2.23772503935168 2.74675203210827 1 4.27215568049862 2519 3755 1714 2329 3626 3790 2760 1792 2909 2792 2780 2827 M14177 GO_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 54/179 Gene Ontology BP GO:0070542 9.76780972143696e-07 2.17750277358957e-06 2365 2743.63636363636 2780 8.87983096205698e-08 1430 1.69567109811259 1.86089428561505 1 8.91217656030153 2364 1779 1430 2244 2009 4356 3310 3460 3342 2780 3106 2828 M16182 GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-alpha production. 21/57 Gene Ontology BP GO:0032647 7.33508701269629e-07 1.69352605668567e-06 3945 2985.09090909091 2780 6.66826314391922e-08 1941 1.12749080837244 -1.19090671973005 -1 6.04016598723678 3944 2470 2780 3304 1941 2479 3785 2725 3410 3673 2325 2829 M12387 GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT.html The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. 30/62 Gene Ontology BP GO:0006893 5.76074739486236e-07 1.37774556874278e-06 3720 2801 2782 5.23704445757003e-08 1304 1.08206254358043 -1.13378710304876 -1 5.88681906676139 3719 1304 2928 2782 1868 2093 4156 2682 3057 3785 2437 2830 M15300 GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a humoral immune response. 6/19 Gene Ontology BP GO:0002922 2.42804249130801e-05 3.9376183329176e-05 3700 2575.54545454545 2783 2.4280690209725e-06 558 2.11009994227505 -2.12744723422014 -1 8.62770002931468 3697 987 4382 1666 2783 3453 4582 2120 558 1083 3020 2831 M15084 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 11/35 Gene Ontology BP GO:1902236 0.00577376514795979 0.00706020320831638 3770 3008.63636363636 2786 0.000526270359136207 1130 0.950490338995842 -0.862536287710803 -1 1.89799087046811 3768 2283 2786 2490 3718 1130 2758 4451 4003 3327 2381 2832 M10368 GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. 45/129 Gene Ontology BP GO:0002821 1.33741591650845e-06 2.86421683595422e-06 3720 2872.27272727273 2788 1.21583339049647e-07 1554 1.31601701106114 -1.14125688744367 -1 6.77134667527459 3716 1988 2263 3001 2100 2788 4415 3624 3433 1554 2713 2833 M10608 GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-10 production. 23/70 Gene Ontology BP GO:0032653 3.87191039904049e-06 7.31080926504474e-06 3530 2898.18181818182 2789 3.51992473951081e-07 1245 2.30783383318943 -2.01564964609259 -1 11.0027591493294 3527 3240 1245 2789 2379 4552 2900 3783 2227 2457 2781 2834 M14401 GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. 26/71 Gene Ontology BP GO:0042304 5.35546809681296e-08 2.06867207766244e-07 3585 3048.63636363636 2789 4.86860747925574e-09 1102 1.33867687595311 1.52804107270412 1 8.30618058391 3584 2315 2497 2703 1102 4141 3547 4123 2437 2789 4297 2835 M14907 GO_PROTEIN_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPHOSPHORYLATION.html The process of removing one or more phosphoric residues from a protein. 94/224 Gene Ontology BP GO:0006470 4.01271508859376e-09 4.25585707965337e-08 1885 2310.45454545455 2789 3.64792281446617e-10 164 1.29941227483914 1.62659793429204 1 8.89084977814873 1885 2968 2789 2846 164 3316 1228 2038 2182 3138 2861 2836 M16046 GO_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORYLATION.html The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. 586/1444 Gene Ontology BP GO:0016310 3.37596480379815e-09 3.90887894863711e-08 4390 2780.27272727273 2790 3.37596480892686e-10 146 1.36237564726733 -1.17357268428159 -1 9.36836745932822 4390 889 4501 2708 146 593 4453 4487 2790 3846 1780 2837 M10587 GO_PROSTATE_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a prostate gland are generated and organized. 10/37 Gene Ontology BP GO:0060512 0.000200080914438597 0.000284177328154911 2805 2425.09090909091 2791 1.81908284807879e-05 408 2.48755495512377 -1.89303783033208 -1 8.18899919663836 2805 2791 1619 2100 3139 3046 1655 3846 408 1859 3408 2838 M13042 GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. 11/21 Gene Ontology BP GO:0009200 3.31636255576745e-06 6.35404665995445e-06 2165 2883.36363636364 2793 3.01487959544306e-07 1929 0.919425425861777 -1.00529318273821 -1 4.43541373454229 2162 4015 2793 3875 2345 1929 2303 2944 4032 3320 1999 2839 M16373 GO_TRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_PROCESSING.html The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. 67/118 Gene Ontology BP GO:0008033 2.796443719684e-05 4.48493547167281e-05 1015 2817.72727272727 2793 2.54225387837654e-06 1012 0.747783363569465 -0.768623419501708 -1 3.01827494282426 1012 3509 3455 4119 2793 1360 2546 2073 4026 4234 1868 2840 M10123 GO_SINGLE_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_FERTILIZATION.html The union of male and female gametes to form a zygote. 40/166 Gene Ontology BP GO:0007338 3.40879037010877e-05 5.38700261688735e-05 2705 2757.36363636364 2794 3.0989483534206e-06 601 1.24281193059705 -1.18127951505438 -1 4.92453661988817 2705 3630 2794 4396 2841 601 1598 2766 3917 3923 1160 2841 M12589 GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. 12/36 Gene Ontology BP GO:0042088 2.84573630782208e-05 4.56084006807661e-05 1860 2458.63636363636 2795 2.5870664714159e-06 1142 1.20573131011604 -1.20573131011604 -1 4.85853082203373 1857 2864 2487 3340 2795 1142 2840 1320 3615 3398 1387 2842 M13278 GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. 11/23 Gene Ontology BP GO:0070233 0.00643982678167485 0.00783546010149798 2795 2851.63636363636 2795 0.000587159547161376 1753 2.11666764344498 -2.0954002281293 -1 4.13777486087808 2795 3873 1771 3359 3673 2447 3080 1753 2759 2663 3195 2843 M14926 GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of keratinocyte differentiation. 20/44 Gene Ontology BP GO:0045616 3.74822155555412e-07 9.57787159187549e-07 3755 2802 2795 3.40747472195697e-08 1723 2.3396395657645 -2.02013425273576 -1 13.0714277075004 3752 3368 1723 2795 1743 2362 3246 3981 1877 2642 3333 2844 M16876 GO_CYTOSOLIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_TRANSPORT.html The directed movement of substances or organelles within the cytosol. 125/284 Gene Ontology BP GO:0016482 6.19220085934279e-08 2.28921327882059e-07 4050 2936.27272727273 2795 5.62927366693706e-09 1160 1.29233579752866 -1.07284832758582 -1 7.96586799057759 4047 2711 2795 2776 1160 1569 4043 4431 2703 3185 2879 2845 M10049 GO_REGULATION_OF_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING_BY_RNA.html Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. 8/27 Gene Ontology BP GO:0060966 3.27107833385789e-05 5.18879969391944e-05 1460 2105.36363636364 2798 3.27112648464603e-06 717 1.47741043795924 -1.47741043795924 -1 5.87644039367317 1459 2798 3524 2916 3087 717 753 759 3107 2899 1140 2846 M12146 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. 40/127 Gene Ontology BP GO:0001910 9.31110967443203e-06 1.61915663739281e-05 4155 3017.63636363636 2799 8.46468098389567e-07 1358 1.7907716372274 -1.33889208502645 -1 7.96359790174933 4151 2088 1358 2368 2580 4160 3045 4321 2799 2102 4222 2847 M15829 GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING.html Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. 8/27 Gene Ontology BP GO:0060147 2.88098202642803e-05 4.61255156851909e-05 1460 2193.45454545455 2799 2.88101937736801e-06 718 1.47741043795924 -1.47741043795924 -1 5.94655513351488 1460 2799 4464 2917 3088 718 754 743 3108 2936 1141 2848 M12280 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. 3/15 Gene Ontology BP GO:1901722 1.0725843741214e-06 2.36580011831147e-06 4540 2205 2800 1.07258489181851e-07 3 2.96030979081264 -1.47606136589554 -1 15.4599370192474 4537 884 3881 96 2802 3007 2800 306 3 1756 4183 2849 M14104 GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. 8/18 Gene Ontology BP GO:0042754 2.65079923509108e-05 4.2746055097591e-05 2525 2746.45454545455 2801 2.65083085593657e-06 842 1.28093221294822 -1.28093221294822 -1 5.19502511088573 2524 3356 4188 3291 2801 1887 3686 842 3734 2138 1764 2850 M14617 GO_IRON_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_IMPORT.html The directed movement of iron ions into a cell or organelle. 8/16 Gene Ontology BP GO:0097286 0.000161691695413529 0.000232281727043631 2660 2775.27272727273 2801 1.61703461510415e-05 1965 2.41966803187021 -2.24919105289388 -1 8.1622152371789 2659 3495 4259 3144 3122 1993 2916 2801 2032 2142 1965 2851 M11719 GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 31/83 Gene Ontology BP GO:0030811 0.00241702631788333 0.0030545054964432 2305 2630.81818181818 2802 0.000219971442852883 1700 1.278657254247 -1.11958290307171 -1 2.9851863858914 1903 2975 2301 2946 3465 2802 2088 1700 3637 2819 2303 2852 M15947 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS.html Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. 9/37 Gene Ontology BP GO:1901522 0.000368319671266341 0.000509415619210492 2805 2960.09090909091 2802 3.68380732231569e-05 1349 1.52590076740597 1.76564381641339 1 4.66420484550363 2802 2405 4484 1349 3232 3623 3952 2625 2780 2364 2945 2853 M16764 GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that modulates the frequency, rate or extent of response to reactive oxygen species. 19/43 Gene Ontology BP GO:1901031 7.39217314977587e-06 1.318043776283e-05 2805 2813.72727272727 2803 6.72017998925118e-07 1734 1.9667761876761 -1.41618687859881 -1 8.90943451592837 2803 3605 1734 2863 2519 3707 2079 3970 1948 2561 3162 2854 M10203 GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT.html The directed movement of substances from endoplasmic reticulum to cytosol. 12/32 Gene Ontology BP GO:1903513 0.000860234348791485 0.00113953440269297 3890 2618.09090909091 2804 7.82337180092398e-05 1029 0.871405585931693 -0.912716795744402 -1 2.38078362049723 2047 1813 2804 3569 3336 1029 1757 3026 3889 3890 1639 2855 M15105 GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 135/306 Gene Ontology BP GO:0009123 1.98508126463933e-05 3.26602845914969e-05 905 2541.09090909091 2804 1.80463561495066e-06 886 1.120419370513 -0.880635877412464 -1 4.66559533732032 905 3171 3302 3371 2727 886 1515 2804 3261 4206 1804 2856 M12615 GO_CHLORIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_TRANSPORT.html The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/116 Gene Ontology BP GO:0006821 1.41381357609399e-07 4.29322199725598e-07 3555 2816.72727272727 2805 1.28528515177425e-08 1449 1.45879121294878 1.38432463587331 1 8.62207702495523 3553 2231 2114 3445 1449 4458 2876 2136 2805 2051 3866 2857 M14842 GO_THALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THALAMUS_DEVELOPMENT.html The process in which the thalamus changes over time, from its initial formation to its mature state. 4/31 Gene Ontology BP GO:0021794 0.0200013790711615 0.0233391311956277 1915 2936.18181818182 2805 0.0020183717960578 1419 1.57792514413848 1.57792514413848 1 2.39030389939996 1912 3835 4301 2805 4392 2392 1419 2216 3463 3121 2442 2858 M16043 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 51/151 Gene Ontology BP GO:0032729 8.72587614296341e-06 1.52826265302826e-05 3405 3055.90909090909 2805 7.93264613878379e-07 2152 1.45749654347039 -1.25728515700076 -1 6.5154630303044 3402 3083 2152 3912 2558 2445 4343 2805 3550 2598 2767 2859 M13583 GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 12/25 Gene Ontology BP GO:0090201 8.85454318795393e-06 1.54787816346649e-05 4520 3238.27272727273 2806 8.04961711441136e-07 1866 1.2017538973323 -0.936340063637448 -1 5.36603507870243 4516 1866 2471 2290 2563 3414 4592 4580 2577 2806 3946 2860 M15088 GO_REVERSE_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REVERSE_CHOLESTEROL_TRANSPORT.html The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. 8/24 Gene Ontology BP GO:0043691 0.000606570499358758 0.000816320819861656 3255 2992.54545454545 2806 6.06736130488181e-05 2000 2.49840512888359 2.8483399190367 1 7.16190985891608 3253 2801 4347 2508 3293 4466 2806 2961 2000 2145 2338 2861 M15423 GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 113/230 Gene Ontology BP GO:0006888 2.57918372591373e-06 5.06991957638334e-06 3770 2703.45454545455 2806 2.34471522694621e-07 1054 1.56122054810515 -1.0946049258424 -1 7.673601924757 3767 2381 2806 2709 2285 1054 3503 2973 1584 3774 2902 2862 M13986 GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. 28/88 Gene Ontology BP GO:0043471 3.40049647229033e-05 5.37755624006948e-05 2385 2902.27272727273 2807 3.09140821293539e-06 2052 1.21834615548522 -1.03030148411059 -1 4.82845509370132 2807 2383 2361 2382 2837 4295 3436 2052 3479 2573 3320 2863 M10408 GO_AXO_DENDRITIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXO_DENDRITIC_TRANSPORT.html The directed movement of organelles or molecules along microtubules in neuron projections. 22/46 Gene Ontology BP GO:0008088 2.27608284561252e-05 3.71062242000665e-05 3545 2867.36363636364 2808 2.06918763083848e-06 2063 0.992667860045224 -0.812882964911652 -1 4.08254556523223 3541 2752 3001 2794 2756 2063 3012 2174 3305 3335 2808 2864 M16356 GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. 28/88 Gene Ontology BP GO:0043470 3.40049647229033e-05 5.37755624006948e-05 2385 2927.36363636364 2808 3.09140821293539e-06 2317 1.21834615548522 -1.03030148411059 -1 4.82845509370132 2808 2384 2362 2383 2838 4296 3437 2317 3480 2575 3321 2865 M16505 GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 18/41 Gene Ontology BP GO:0043536 4.00875713643129e-06 7.54210947281519e-06 2900 2807.45454545455 2809 3.64433131005109e-07 1111 1.43097211371396 1.39536379581073 1 6.80429093158523 2897 2237 2000 2023 2384 3522 2809 4566 3116 1111 4217 2866 M10983 GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. 8/17 Gene Ontology BP GO:1903504 1.48896050100234e-06 3.15241386509524e-06 3040 2771.72727272727 2810 1.4889614986548e-07 1663 1.06609202799581 -1.2643069486722 -1 5.44419449765771 3039 3354 3667 2363 2145 2146 2591 3074 2810 3637 1663 2867 M14203 GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epidermal cell differentiation. 30/67 Gene Ontology BP GO:0045604 8.26409679229681e-08 2.81926534949553e-07 4300 2858.36363636364 2811 7.51281554793634e-09 1275 2.47191553061952 -1.90736583518357 -1 15.0291717686746 4296 3147 1471 2245 1275 2811 4050 3992 1368 2708 4079 2868 M15165 GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. 8/17 Gene Ontology BP GO:0090266 1.48896050100234e-06 3.15241386509524e-06 2150 2841 2811 1.4889614986548e-07 1664 1.06609202799581 -1.2643069486722 -1 5.44419449765771 3040 3355 4365 2364 2146 2147 2592 3110 2811 3657 1664 2869 M11464 GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. 5/20 Gene Ontology BP GO:0007216 0.0765897756730953 0.0843068583333764 3255 2975.18181818182 2812 0.00793650793650794 1480 1.7918910709134 -1.68851903631607 -1 1.78665382229385 3251 2537 3751 2350 3990 3967 2461 3863 1480 2265 2812 2870 M14354 GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. 55/137 Gene Ontology BP GO:0006733 5.68381727127202e-05 8.64961114077876e-05 1535 2510.81818181818 2812 5.16724011002958e-06 378 1.19506925679167 -1.00836332082384 -1 4.50722651420106 1532 3423 2812 4018 3119 378 1534 2607 3599 3666 931 2871 M13934 GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 104/244 Gene Ontology BP GO:0046824 7.66358446524456e-07 1.75626962843685e-06 2460 2982.27272727273 2814 6.96689739528661e-08 1570 1.61411901053815 -1.11097530034054 -1 8.62344626817117 2459 4069 2343 3556 1957 4273 2589 1570 2814 3524 3651 2872 M11292 GO_HORMONE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_TRANSPORT.html The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 37/118 Gene Ontology BP GO:0009914 3.07969694704353e-05 4.91206902271491e-05 2975 2824.81818181818 2815 2.79976369036671e-06 1104 1.90135480021318 2.19640908881213 1 7.60470085486954 2972 2911 1104 2514 2815 3873 2643 3854 2421 1543 4423 2873 M12462 GO_PROTEIN_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DESTABILIZATION.html Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. 21/51 Gene Ontology BP GO:0031648 9.85336416260175e-08 3.23315687681696e-07 3235 2627.18181818182 2817 8.95760418537675e-09 829 0.933447429382227 -1.00813407980542 -1 5.6237843873176 3231 829 2637 3215 1332 2201 2817 3658 3448 3248 2283 2874 M13257 GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of receptor activity. 26/62 Gene Ontology BP GO:2000273 1.46195742137112e-05 2.45937257515438e-05 4215 2935.90909090909 2817 1.32906103322741e-06 1646 1.17816180733934 -0.974625364689839 -1 5.04077515269451 4213 2314 2817 2604 2667 2228 3780 1646 3103 3241 3682 2875 M10602 GO_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_UPTAKE.html The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. 5/22 Gene Ontology BP GO:0001504 2.36256837228712e-06 4.69178997114162e-06 3195 2380.72727272727 2818 2.36257088406907e-07 24 2.72989975177989 -0.678657906030477 -1 13.5031148782276 3192 2205 3610 924 2641 3997 3123 385 24 3269 2818 2876 M11588 GO_CREATINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CREATINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. 4/10 Gene Ontology BP GO:0006600 1.23068740797411e-05 2.10153793130702e-05 3065 2581.45454545455 2819 1.23069422368897e-06 1442 1.26180081172638 1.2489837498531 1 5.47860850917524 3063 1502 3773 1907 2649 3144 3050 2974 1442 2073 2819 2877 M13812 GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. 15/36 Gene Ontology BP GO:0002437 3.11996840744673e-05 4.9694728356004e-05 2350 2894.27272727273 2819 2.83637514063808e-06 1506 1.61907198999121 -1.53546416930385 -1 6.4680927177904 2347 3009 1924 3803 2819 2490 1506 4062 3865 2606 3406 2878 M13858 GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. 31/69 Gene Ontology BP GO:0006687 3.46876476567178e-06 6.60060442910413e-06 3440 3064.81818181818 2820 3.15342748629483e-07 1938 1.41322256137499 1.53820946202992 1 6.795858881117 3438 2616 2293 2499 2357 4073 3630 4354 1938 2820 3695 2879 M13906 GO_TRACHEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_DEVELOPMENT.html The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. 13/31 Gene Ontology BP GO:0060438 3.16937329491994e-05 5.03952061928537e-05 3740 3091.81818181818 2821 2.88128995872755e-06 2144 1.39334846774647 -1.62509520789646 -1 5.55847875863492 3736 3057 2213 2144 2821 4546 3371 2590 2740 2312 4480 2880 M16632 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 36/106 Gene Ontology BP GO:0042346 5.74288355520507e-06 1.04688686088799e-05 2300 2878.54545454545 2821 5.22081686044761e-07 1646 1.26030032794042 -1.20221816833689 -1 5.82614463201972 2296 3364 2821 4350 2467 1646 2888 2589 3638 3533 2072 2881 M10548 GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 11/33 Gene Ontology BP GO:0009261 3.22576175462471e-05 5.12742616457464e-05 3255 2793.45454545455 2822 2.93255368499975e-06 1404 1.65404337609341 2.01281465175997 1 6.58693682119507 3252 3249 2158 3499 2822 4074 2677 1489 1404 2648 3456 2882 M12960 GO_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 20/45 Gene Ontology BP GO:0036314 5.42504712175292e-06 9.95199280375298e-06 4165 2997.54545454545 2822 4.93187318144392e-07 2036 1.81521125836254 -1.71612460798811 -1 8.42845175240986 4161 2918 2036 2757 2453 2250 3725 2822 2694 3160 3997 2883 M12181 GO_ESTABLISHMENT_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization or cell growth patterns. 69/172 Gene Ontology BP GO:0030010 3.49211692958775e-08 1.52012182258062e-07 2890 2886.90909090909 2824 3.17465180456274e-09 959 1.80383443643184 1.95536899388126 1 11.4164361235317 2888 3788 1929 2342 959 4590 2178 4121 1784 2824 4353 2884 M13637 GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. 68/218 Gene Ontology BP GO:0002706 1.36681418156482e-06 2.92313138876345e-06 4285 2884.72727272727 2825 1.2425591188534e-07 1488 1.65537300604024 -1.36743486358574 -1 8.50385913559714 4282 2347 1856 2749 2104 3380 4039 3306 2825 1488 3356 2885 M12202 GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. 7/10 Gene Ontology BP GO:0006995 1.43047239342664e-05 2.41077434580032e-05 2830 3020.81818181818 2828 1.43048160164077e-06 2291 0.964489176054805 0.975107447763925 1 4.13433518691705 2828 2492 3868 3265 2689 3169 2785 2291 4115 2722 3005 2886 M12519 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. 10/27 Gene Ontology BP GO:0031112 0.0839184282471183 0.0891201423493528 2815 3088.63636363636 2828 0.00793650793650794 1465 2.23425999906677 2.23425999906677 1 2.17772025562266 2811 4513 2568 2801 4342 3767 2993 2690 1465 3197 2828 2887 M16215 GO_DNA_PACKAGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING.html Any process in which DNA and associated proteins are formed into a compact, orderly structure. 102/328 Gene Ontology BP GO:0006323 0.00790987587703833 0.00955399419799401 1180 2838.27272727273 2828 0.000721678091697013 1180 1.5352924843292 -1.48850877693495 -1 2.87853712047811 1180 3858 2242 3428 3616 2125 2825 2828 3385 3017 2717 2888 M14031 GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. 7/10 Gene Ontology BP GO:0043562 1.43047239342664e-05 2.41077434580032e-05 2830 3046.54545454545 2829 1.43048160164077e-06 2243 0.964489176054805 0.975107447763925 1 4.13433518691705 2829 2493 4175 3266 2690 3170 2786 2243 4116 2738 3006 2889 M14805 GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of DNA biosynthetic process. 55/119 Gene Ontology BP GO:2000278 0.0187681965273553 0.021949807676703 2405 2970.81818181818 2829 0.00172093152253266 1750 1.88032307577883 2.09738194159244 1 2.89491092212966 2401 4159 1750 3062 3882 4370 2908 2015 2738 2565 2829 2890 M16251 GO_REGULATION_OF_CELLULAR_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. 38/95 Gene Ontology BP GO:0030641 2.45496612785296e-05 3.97434021325708e-05 3940 2840.54545454545 2829 2.23181229372106e-06 1897 1.53064060015275 -1.20756845049302 -1 6.25269968498249 3937 1897 2111 2439 2773 2829 4512 2965 2845 1925 3013 2891 M13131 GO_ESTABLISHMENT_OF_TISSUE_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_TISSUE_POLARITY.html Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 13/29 Gene Ontology BP GO:0007164 4.45591743487618e-07 1.10438481493348e-06 3685 2682.81818181818 2830 4.05083485216867e-08 330 1.77322676513841 -1.07926976000643 -1 9.80510460970469 3683 1860 1869 1573 1798 4460 4009 2830 330 2959 4140 2892 M16025 GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. 20/37 Gene Ontology BP GO:0044803 3.32018302134122e-05 5.2630965408287e-05 2185 2531.36363636364 2830 3.01839375431108e-06 713 0.895685271834997 -0.750225376341346 -1 3.55747897328565 2182 3241 2916 4331 2830 713 1777 1399 4265 3167 1024 2893 M14145 GO_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT.html Any process that modulates the frequency, rate or extent of protein import. 136/325 Gene Ontology BP GO:1904589 1.60879923678055e-07 4.78517287403722e-07 2945 2964.27272727273 2832 1.46254486766146e-08 1485 1.48685147505188 -1.06907500647876 -1 8.7228987767624 2944 4088 2554 2769 1485 4043 2627 2122 2832 3246 3897 2894 M16761 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 15/43 Gene Ontology BP GO:1902175 1.45045054763673e-05 2.44197796591822e-05 3835 2816.54545454545 2832 1.31860010043922e-06 696 1.09954211576306 -0.902067941693375 -1 4.7075464011856 3832 696 2832 898 2664 4566 3770 2563 1415 3184 4562 2895 M16880 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin depolymerization. 9/21 Gene Ontology BP GO:0030836 3.06616321288774e-05 4.89552812841739e-05 4355 2953.54545454545 2834 3.06620551981512e-06 1689 1.66745630528748 -2.2480167599787 -1 6.6714626528665 4353 1924 4629 1874 2834 4351 2997 1689 2064 2375 3399 2896 M12597 GO_DNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS.html The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 15/30 Gene Ontology BP GO:0006308 9.72580701935559e-05 0.000143309812728873 1225 2548 2835 8.8420336422943e-06 448 1.39028935122992 -1.39028935122992 -1 4.96051222491451 1221 4171 2835 4397 4566 448 471 1288 4166 3686 779 2897 M14724 GO_UBIQUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. 9/13 Gene Ontology BP GO:0006743 0.000471654680893639 0.000644086083349755 1640 2852.27272727273 2836 4.71754816969147e-05 1522 0.729748559510922 -0.729748559510922 -1 2.16160723299944 1639 2836 4282 3461 3260 1522 2019 2202 3922 4532 1700 2898 M11111 GO_LYMPH_NODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_NODE_DEVELOPMENT.html The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. 8/17 Gene Ontology BP GO:0048535 6.24877733485929e-06 1.13139534018465e-05 2700 2785.09090909091 2837 6.24879490617702e-07 1493 1.27845841291727 -0.867822660198102 -1 5.87007571444433 2698 1493 3693 2320 2504 2541 2939 3753 2837 2908 2950 2899 M14421 GO_KETONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 17/38 Gene Ontology BP GO:0042181 1.81464993624142e-06 3.73467183243302e-06 4275 2958.36363636364 2837 1.649683120946e-07 1471 1.3284117228269 -0.809711077570666 -1 6.6930099212409 4271 2275 2543 2158 2180 2988 4325 2837 1471 3360 4134 2900 M15189 GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. 66/198 Gene Ontology BP GO:0002761 1.92621524344316e-06 3.9191136613964e-06 4360 3154 2837 1.75110629995234e-07 2198 1.52288957547819 -1.73004766833888 -1 7.64326337291648 4357 2611 2410 3911 2198 2837 4375 2770 3577 2389 3259 2901 M16095 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. 17/46 Gene Ontology BP GO:1903170 1.66284064748602e-07 4.91130351544376e-07 4090 2755.63636363636 2837 1.5116734301542e-08 1155 1.33378567607203 -0.955400865992004 -1 7.81091949725122 4089 1155 2214 1169 1496 4186 4281 3392 1567 2837 3926 2902 M12791 GO_POLYOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSPORT.html The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/22 Gene Ontology BP GO:0015791 3.09375496475558e-05 4.93279680678576e-05 3090 2612.27272727273 2839 3.09379803653853e-06 866 2.67083509738839 2.62568548780399 1 10.6777974866631 3089 866 3961 1504 2839 3556 2167 3875 1775 1651 3452 2903 M14730 GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. 86/294 Gene Ontology BP GO:0030522 1.70963570154833e-06 3.54684475526761e-06 4435 3164.09090909091 2839 1.55421548192717e-07 2162 1.49855939166699 -1.49273749438143 -1 7.58144814186698 4432 4004 2447 3150 2162 2783 4115 3900 2518 2455 2839 2904 M15054 GO_PARAXIAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARAXIAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. 9/23 Gene Ontology BP GO:0048339 1.3202619203225e-05 2.24212732116216e-05 1920 2607 2839 1.32026976430001e-06 636 1.9635970626035 -1.9635970626035 -1 8.47447469050229 1917 4458 4341 2839 3382 981 2268 636 3650 3086 1119 2905 M16326 GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. 12/22 Gene Ontology BP GO:2000479 0.000401441441205126 0.000551937403469174 1750 2757.45454545455 2840 3.65013374819494e-05 1569 0.987630698715773 1.13656993799374 1 2.98696036153577 1749 3058 2840 3299 3231 2592 1569 3205 2709 3404 2676 2906 M10572 GO_PROTEIN_HOMOTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTETRAMERIZATION.html The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. 42/87 Gene Ontology BP GO:0051289 9.19854289335208e-08 3.07036913399236e-07 3265 2690.72727272727 2841 8.36231207087048e-09 1307 1.45853338905365 -1.11594541728951 -1 8.81767072025646 2898 3263 2223 3027 1307 1668 2795 4151 2164 3261 2841 2907 M11379 GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY.html The initiation of the activity of the inactive enzyme JUN kinase (JNK). 17/58 Gene Ontology BP GO:0007257 5.68223303164711e-07 1.36133168038893e-06 2525 2992.54545454545 2841 5.16566772661241e-08 1864 1.18208979378134 -1.06594558673062 -1 6.43671564411651 2522 2982 2758 4529 1864 2578 1892 2841 3979 3355 3618 2908 M16666 GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 12/39 Gene Ontology BP GO:0035458 0.000623192676711593 0.000837234837376136 3100 3054.72727272727 2841 5.6669934378759e-05 2254 0.926221016121685 -0.878953551315316 -1 2.64565243347631 3097 2828 2841 2753 3284 2254 2740 3930 3877 3406 2592 2909 M10467 GO_MYELOID_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 68/127 Gene Ontology BP GO:0002262 4.75460908235636e-08 1.89684007763674e-07 2605 2764.09090909091 2842 4.32237198646573e-09 1061 1.48619724027609 1.87468213625512 1 9.27346648617822 2603 3684 2658 2842 1061 4366 2965 1593 2014 3720 2899 2910 M15265 GO_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. 92/251 Gene Ontology BP GO:0034341 7.12284851847009e-07 1.65026874607069e-06 3885 2998.36363636364 2842 6.47531893146017e-08 1617 1.68621402501995 1.89663053985044 1 9.05093330699141 2730 3885 1617 3881 1933 4437 2842 2281 3212 2106 4058 2911 M15755 GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. 10/24 Gene Ontology BP GO:1904666 3.12668641702871e-06 6.03124430173008e-06 2845 2732 2843 2.84244623704568e-07 1383 1.06609202799581 -1.2643069486722 -1 5.16535848326362 2843 3672 2888 2824 2331 1680 2337 2947 3325 3822 1383 2912 M16947 GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. 73/199 Gene Ontology BP GO:0002700 5.17973328739376e-06 9.53588487445251e-06 4045 2995.45454545455 2843 4.70885952974861e-07 1653 1.84129556930534 -1.46309176901238 -1 8.58127135701848 4043 3422 1653 2624 2443 2843 4400 3531 2332 2229 3430 2913 M11669 GO_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. 658/1788 Gene Ontology BP GO:0016192 9.99885087773163e-09 6.85740984125671e-08 2845 2669.45454545455 2844 9.99885092272127e-10 524 1.59229192324054 -1.29937361478327 -1 10.5885793908948 2844 1646 3786 2541 524 3691 3029 3407 2417 962 4517 2914 M14270 GO_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_ELONGATION.html The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. 70/123 Gene Ontology BP GO:0006414 0.00294058894547043 0.00369503504027583 3490 2601.09090909091 2844 0.000267684254511413 332 0.609656353770446 -0.609230517576646 -1 1.37653057732378 332 2844 3486 3017 3489 1096 1832 2142 3984 4253 2137 2915 M13386 GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 64/164 Gene Ontology BP GO:0016051 2.29846006711773e-08 1.14014424055851e-07 3935 2786.54545454545 2845 2.08950917375545e-09 810 1.53717075583164 -1.21684779563264 -1 9.9069718010354 3932 2307 1748 2845 810 3057 3692 3467 2634 1718 4442 2916 M14545 GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. 12/21 Gene Ontology BP GO:2000773 0.000419311103840285 0.000575824151177297 2575 2655.09090909091 2845 3.81264585611585e-05 730 1.76473542543951 -0.642299538898271 -1 5.30707081210219 2573 3670 2258 3124 3589 3137 2204 1172 730 3904 2845 2917 M10976 GO_ERYTHROCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_HOMEOSTASIS.html Any process of regulating the production and elimination of erythrocytes within an organism. 60/106 Gene Ontology BP GO:0034101 5.62522055136932e-08 2.13556001798919e-07 2470 2807.18181818182 2846 5.11383699563783e-09 1126 1.46862389712656 1.8110418426284 1 9.09363135914233 2467 3812 2650 2942 1126 4578 2950 1910 1967 3631 2846 2918 M11247 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. 3/14 Gene Ontology BP GO:0002839 0.000994178295088735 0.00130726984539705 3780 3072.81818181818 2847 9.94623351059201e-05 2403 1.09496761871584 -1.46370832723374 -1 2.93096504842639 3778 2704 3716 2730 3363 3367 3680 2452 2403 2847 2761 2919 M10716 GO_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROPTOTIC_PROCESS.html A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. 24/46 Gene Ontology BP GO:0070266 2.16908991104053e-06 4.3503604565707e-06 4310 3096.18181818182 2848 1.97190186332508e-07 1060 1.29123097239887 -1.13067532518417 -1 6.42624573850737 4308 1060 2387 1829 2235 3762 3951 4491 2848 2615 4572 2920 M10440 GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. 16/29 Gene Ontology BP GO:0045648 3.82112456106577e-05 5.98767510530826e-05 2880 2763.09090909091 2850 3.47380993711748e-06 1974 1.34925644873841 1.5019362265817 1 5.28881227837705 2878 2058 1974 2215 2856 4507 2850 2283 3437 2191 3145 2921 M11484 GO_MEMBRANE_RAFT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_RAFT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. 8/25 Gene Ontology BP GO:0031579 2.41586143309937e-07 6.6453835149507e-07 2835 2790.45454545455 2851 2.4158616957368e-08 587 0.830707439053992 0.803790084338362 1 4.76352630498 2831 587 3756 2139 1648 2898 2366 4490 2851 3641 3488 2922 M15674 GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune effector process. 246/673 Gene Ontology BP GO:0002697 5.77519181526431e-08 2.18004113576288e-07 3950 2729.63636363636 2851 5.25017451533465e-09 1133 1.60354851143969 -1.30552927155039 -1 9.9157500462292 3949 2302 1248 3193 1133 2851 3211 3906 2306 1894 4033 2923 M10185 GO_ANTEROGRADE_AXONAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_AXONAL_TRANSPORT.html The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. 15/32 Gene Ontology BP GO:0008089 3.76734428992218e-05 5.91134639648828e-05 2660 2499.90909090909 2853 3.42491709506673e-06 1108 0.935594620733387 -0.85232303999956 -1 3.67218052758622 2660 3038 2968 2913 2853 1177 2356 1108 3714 3172 1540 2924 M11295 GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 12/29 Gene Ontology BP GO:0010832 1.99233216878848e-05 3.27447726006545e-05 4585 3052.63636363636 2853 1.8112274651705e-06 773 1.81522613202925 -1.81861170373662 -1 7.55698507596969 4045 2561 1409 2853 2728 4582 3863 3432 2748 773 4585 2925 M12418 GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of mast cell degranulation. 6/16 Gene Ontology BP GO:0043306 4.20035760265098e-07 1.05133478970935e-06 2855 2598.63636363636 2854 4.20035839658636e-08 628 1.38642112443459 1.855154317519 1 7.69376685007158 2854 1575 3905 1887 1813 3835 3237 3204 628 3427 2220 2926 M12939 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. 6/16 Gene Ontology BP GO:0033008 4.20035760265098e-07 1.05133478970935e-06 2855 2608.09090909091 2855 4.20035839658636e-08 629 1.38642112443459 1.855154317519 1 7.69376685007158 2855 1576 3984 1888 1814 3836 3238 3218 629 3430 2221 2927 M13434 GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. 15/26 Gene Ontology BP GO:0001836 5.55972902150672e-05 8.47188114435697e-05 2315 2767.81818181818 2855 5.05442684467741e-06 1507 1.15853871352266 -1.06698490060651 -1 4.37914767294688 2315 2276 2855 3300 2940 1507 1926 3280 3851 3688 2508 2928 M14855 GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 18/30 Gene Ontology BP GO:0032878 0.013904810794723 0.0164778041143183 3410 3000 2856 0.00127213453751721 1880 1.31721470538972 -1.61910218080253 -1 2.18022609792908 3406 2426 2193 3213 3833 2856 4257 2853 3666 2417 1880 2929 M15190 GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. 14/45 Gene Ontology BP GO:0042743 1.44157552996744e-07 4.35757499065028e-07 3915 2940.81818181818 2857 1.31052329493487e-08 1458 1.62869173422845 -1.30608772345904 -1 9.61649261042658 3912 2857 2038 2205 1458 2790 3992 4159 2589 3045 3304 2930 M13861 GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. 3/16 Gene Ontology BP GO:0002837 0.000994178295088735 0.00130726984539705 3780 3110.45454545455 2858 9.94623351059201e-05 2404 1.09496761871584 -1.46370832723374 -1 2.93096504842639 3779 2705 4147 2731 3364 3368 3681 2416 2404 2858 2762 2931 M10849 GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. 18/53 Gene Ontology BP GO:0002701 0.0272471200595823 0.0314619195316192 2630 3031.09090909091 2859 0.00250823152694972 1593 1.40759702844764 -1.6053852303658 -1 1.96281546103362 2628 3894 2540 4347 3906 1593 2859 2776 3552 2986 2261 2932 M13866 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. 3/14 Gene Ontology BP GO:0002836 0.000994178295088735 0.00130726984539705 3780 3111.54545454545 2859 9.94623351059201e-05 2405 1.09496761871584 -1.46370832723374 -1 2.93096504842639 3780 2706 4149 2732 3365 3369 3682 2417 2405 2859 2763 2933 M10835 GO_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_LOCALIZATION.html Any process in which is the spindle is transported to, and/or maintained in, a specific location. 26/67 Gene Ontology BP GO:0051653 6.34853144554793e-06 1.1465215717225e-05 2885 2945.36363636364 2861 5.77140887777677e-07 1788 2.17923882466045 2.8954605142877 1 9.99436525109478 2881 3637 2095 2861 2482 4341 2903 2394 1788 2784 4233 2934 M12909 GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 45/133 Gene Ontology BP GO:0048259 1.33165546479721e-06 2.85319627275194e-06 4565 2914.18181818182 2861 1.21059660986018e-07 1522 1.37475323288291 -1.16962396267446 -1 7.0757006953279 4399 1522 1960 1815 2098 2861 4565 4564 2972 2120 3180 2935 M16296 GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. 9/35 Gene Ontology BP GO:0032925 0.0312885361435165 0.0359585825035512 2540 3137.63636363636 2862 0.00317380064778885 2157 1.52650771836493 1.52650771836493 1 2.04641953693084 2536 2638 4543 3961 3890 3511 2382 2862 3664 2370 2157 2936 M13281 GO_4_HYDROXYPROLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_HYDROXYPROLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. 12/15 Gene Ontology BP GO:0019471 0.000158570528896388 0.000228080224803571 3760 3202.18181818182 2863 1.44165417653837e-05 2181 1.12364411825841 -0.899618193210464 -1 3.79863349397614 3759 2863 2710 2513 3101 4046 4333 2824 2603 2181 4291 2937 M16192 GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of a response to tumor cell. 3/16 Gene Ontology BP GO:0002834 0.000994178295088735 0.00130726984539705 3370 3144 2863 9.94623351059201e-05 2385 1.09496761871584 -1.46370832723374 -1 2.93096504842639 3781 2707 4526 2733 3366 3370 3683 2385 2406 2863 2764 2938 M16526 GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 3/17 Gene Ontology BP GO:0043950 0.000449508921816517 0.000615291840800143 2260 2666.09090909091 2864 4.49599873932506e-05 576 2.59336136913912 2.59336136913912 1 7.72967967932393 2258 3198 4575 2918 4074 2012 576 1859 3717 2864 1276 2939 M11446 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 22/63 Gene Ontology BP GO:0010719 1.92583420918414e-06 3.9191136613964e-06 4310 3093.09090909091 2868 1.75075990456489e-07 2090 1.31701891419921 -1.36465756862802 -1 6.61001463826014 4306 2090 2454 2099 2197 3588 3423 4478 2691 2868 3830 2940 M16934 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. 6/21 Gene Ontology BP GO:0023019 0.00648499675816749 0.00788835209540783 2600 2946.54545454545 2869 0.000650399968520148 1711 3.58609653278664 3.58609653278664 1 7.00056689875416 2600 3253 4639 1929 3608 3544 2452 2869 1711 3465 2342 2941 M10359 GO_NATURAL_KILLER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. 7/15 Gene Ontology BP GO:0001779 3.63465083477989e-05 5.71330328574756e-05 3675 2687.54545454545 2870 3.6347102842385e-06 115 2.10674203750858 2.5163955885264 1 8.29784010589384 3671 2571 3572 1419 2870 4637 2945 1771 115 2714 3278 2942 M14915 GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. 52/123 Gene Ontology BP GO:1904029 7.63990817530707e-08 2.6491481447312e-07 2995 2634.90909090909 2870 6.94537130965188e-09 1222 1.54589400562323 2.00081565088766 1 9.43777614752422 2887 3313 2035 2994 1250 4408 2690 1222 2870 2991 2324 2943 M11544 GO_PROTEIN_LOCALIZATION_TO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CENTROSOME.html A process in which a protein is transported to, or maintained at, the centrosome. 10/22 Gene Ontology BP GO:0071539 6.85549520216146e-05 0.000102810284960064 1365 2303.27272727273 2871 6.23246257991905e-06 480 0.937874849444541 -0.937874849444541 -1 3.47188374398303 1361 3302 2944 2871 3288 480 1179 1596 3839 3798 678 2944 M13791 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. 22/66 Gene Ontology BP GO:0002639 0.0023027835083847 0.00291568689103632 2480 2855.45454545455 2871 0.000209563401411229 2057 1.46713806704213 -1.25567885627973 -1 3.45272870329274 2480 2653 2319 2941 3459 2057 3112 3728 3091 2871 2699 2945 M14589 GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that activates or increases the frequency, rate or extent of protein acetylation. 22/48 Gene Ontology BP GO:1901985 5.25349913216219e-05 8.03160897946297e-05 2865 2802.18181818182 2872 4.77602235227904e-06 2023 1.36658520805783 1.35174195169832 1 5.19494179750112 2863 2137 2023 2697 2931 3201 2046 3370 3168 2872 3516 2946 M15907 GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. 36/93 Gene Ontology BP GO:0045071 4.00475517979223e-05 6.25431493433412e-05 2145 2856.72727272727 2872 3.64075280176479e-06 1226 1.27351817599219 -1.33364509605204 -1 4.96956540079357 2144 4040 2662 4393 2872 1226 2967 1778 4030 3229 2083 2947 M16437 GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. 5/15 Gene Ontology BP GO:1900121 0.000128513848739549 0.00018646556240554 2580 2872.90909090909 2872 1.28521281458714e-05 1481 1.4850608061708 1.4850608061708 1 5.1410578016716 2578 2872 4564 1813 3086 3684 2904 2537 1481 3294 2789 2948 M12842 GO_CILIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MORPHOGENESIS.html A process that is carried out at the cellular level and in which the structure of a cilium is organized. 122/309 Gene Ontology BP GO:0060271 6.64782713713587e-08 2.3908490625656e-07 3730 2763.90909090909 2874 6.04347939819627e-09 1192 1.19212863608399 -1.18833137059621 -1 7.32732091474925 3728 2082 3173 3082 1192 1531 4083 2874 2606 3931 2121 2949 M13034 GO_MULTIVESICULAR_BODY_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 22/34 Gene Ontology BP GO:0036257 0.000368524017654314 0.000509546460383854 1840 2769.09090909091 2874 3.35077967210383e-05 630 0.961290572162699 -0.586690413447753 -1 2.93826719448319 1836 3578 2874 3804 4119 630 1268 2673 4232 3708 1738 2950 M15561 GO_PEPTIDYL_LYSINE_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_TRIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. 14/28 Gene Ontology BP GO:0018023 0.000268321500886311 0.000375585386980749 1920 2617.18181818182 2877 2.43958392840296e-05 824 1.23378701142348 -1.23378701142348 -1 3.922896289885 1918 3726 2877 4023 4064 824 1259 1089 3805 3976 1228 2951 M11729 GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. 46/110 Gene Ontology BP GO:0033238 8.85816665154796e-06 1.54792878295586e-05 2985 2715.72727272727 2878 8.05291119874556e-07 1358 1.3763029088595 -0.893273464764332 -1 6.14540791987454 2983 2309 2878 1968 2564 1810 3327 3872 1358 3722 3082 2952 M12056 GO_PEPTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 325/740 Gene Ontology BP GO:0006518 4.07805322022361e-05 6.35169443190144e-05 1000 2522.09090909091 2878 3.70738983222668e-06 435 1.08396593898232 -0.865342164339915 -1 4.22313680568749 999 3883 3505 3855 2878 435 1410 1985 3360 4267 1166 2953 M12099 GO_RESPONSE_TO_MAGNESIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MAGNESIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. 9/45 Gene Ontology BP GO:0032026 3.59561306879688e-05 5.66296861547622e-05 2305 2810.18181818182 2878 3.59567124807179e-06 1978 1.19719605472941 1.34221995343414 1 4.71967556904353 2305 3016 3848 2985 2867 3265 2201 1978 2878 2341 3228 2954 M14399 GO_GDP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. 7/17 Gene Ontology BP GO:0046710 4.96916544049113e-05 7.63462446730653e-05 1605 2385.72727272727 2879 4.96927656071153e-06 718 0.97428396999414 -0.97428396999414 -1 3.72355642443241 1603 2991 4234 2879 2939 785 928 1335 4263 3568 718 2955 M13259 GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. 78/178 Gene Ontology BP GO:0032845 0.0167841804486076 0.0197638726408534 1945 2850 2880 0.00153760131420364 1943 1.56524032191805 1.78158544136692 1 2.47600965609759 2316 2970 1943 3167 4528 3844 1981 2880 3185 2591 1945 2956 M15553 GO_GMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GMP, guanosine monophosphate. 9/27 Gene Ontology BP GO:0046037 1.81532644058198e-05 3.00912554931172e-05 1330 2227.54545454545 2880 1.81534127009786e-06 436 1.12436924486037 -1.12436924486037 -1 4.71917790510131 1327 3282 4420 3462 2880 436 518 722 3891 3090 475 2957 M10879 GO_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SECRETION.html The controlled release of proteins from a cell. 57/190 Gene Ontology BP GO:0009306 1.01706864050127e-08 6.91398198806351e-08 2715 2724.72727272727 2882 9.24607859275648e-10 490 1.66108724736583 2.12233640320821 1 11.0405595310233 2712 3860 2123 3468 490 3710 2882 1461 2940 2388 3938 2958 M11500 GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 31/76 Gene Ontology BP GO:0002755 9.10784767287964e-05 0.00013458859562438 3235 2595 2882 8.28020432120223e-06 1212 1.29675919827155 -1.30621793507438 -1 4.65962219162922 2282 2882 2631 3234 3017 1212 3240 2022 3419 3232 1374 2959 M11633 GO_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_SECRETION.html The controlled release of a peptide from a cell or a tissue. 27/82 Gene Ontology BP GO:0002790 0.0839184282471183 0.0891201423493528 2500 3034.72727272727 2882 0.00793650793650794 1693 1.86178125520129 2.65725430530625 1 1.81466735149168 2497 3548 1693 3526 4179 3627 2557 2574 2880 2882 3419 2960 M12546 GO_ER_NUCLEUS_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_NUCLEUS_SIGNALING_PATHWAY.html Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. 26/50 Gene Ontology BP GO:0006984 0.00131958493200393 0.00171764307241218 2885 3092.72727272727 2883 0.000120034281753799 1681 1.58465550542451 1.70937575144774 1 4.06733230017995 2883 3820 2382 2761 3385 4635 2747 1681 2829 3239 3658 2961 M15159 GO_RESPONSE_TO_DEXAMETHASONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DEXAMETHASONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 16/45 Gene Ontology BP GO:0071548 6.82314524105222e-05 0.000102490661126514 2675 2776.81818181818 2883 6.20305169571901e-06 924 2.32988553746563 -2.14330027774235 -1 8.627840826496 2675 3183 924 2324 2970 3834 2397 3680 2883 2202 3473 2962 M12553 GO_EPITHELIAL_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. 21/60 Gene Ontology BP GO:0003351 0.000516186118074483 0.000700980446393632 2935 2783 2884 4.69370246044899e-05 1727 1.15152200711521 -1.2196666090234 -1 3.37165819697608 2935 2884 2808 3179 3259 1727 2712 2027 3511 3669 1902 2963 M15746 GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 199/495 Gene Ontology BP GO:0072521 1.20571889827157e-07 3.80144487666072e-07 2220 2729.90909090909 2884 1.09610814941045e-08 1193 1.32964322743105 -1.02015577070136 -1 7.92396877371293 2217 3045 3081 3878 1393 1193 2257 3700 2884 3991 2390 2964 M10613 GO_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 100/221 Gene Ontology BP GO:0051783 7.89004182511108e-09 6.00548593344111e-08 2965 2732.81818181818 2885 7.17276532127982e-10 390 1.55870393130558 -1.30872689375459 -1 10.4485802866936 2963 4252 2538 3247 390 1519 2473 2885 3214 4052 2528 2965 M13707 GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. 18/43 Gene Ontology BP GO:2000300 4.63931251638438e-05 7.15863343754492e-05 2565 2968.72727272727 2885 4.21764577463073e-06 1807 1.25431585153533 1.10962334759355 1 4.8263450525993 2563 1807 2610 3276 2902 3590 2885 4508 3417 2415 2683 2966 M13789 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. 14/27 Gene Ontology BP GO:0034198 0.0113202034588814 0.0135254000668004 2885 2975.18181818182 2885 0.00103444319937659 1503 0.769343977035438 -0.645837080530777 -1 1.33463973664937 2885 2392 3057 3870 3691 1503 2488 1882 4310 3972 2677 2967 M10843 GO_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. 17/41 Gene Ontology BP GO:0033233 0.000113357641185563 0.000165613444941651 2340 2763.27272727273 2886 1.03057711359538e-05 752 1.15467279424686 -1.16788712950302 -1 4.0525067896081 2336 3795 2843 3816 4030 840 2051 2886 3694 3353 752 2968 M12832 GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. 21/61 Gene Ontology BP GO:0034123 9.12346620506768e-06 1.58950294897295e-05 3740 3016.18181818182 2886 8.29409458234205e-07 2102 1.42126394202113 -1.52217465046112 -1 6.33098034538028 3739 2949 2349 3594 2574 2886 4419 2102 3659 2238 2669 2969 M13134 GO_CELL_SEPARATION_AFTER_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SEPARATION_AFTER_CYTOKINESIS.html The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components. 10/17 Gene Ontology BP GO:0000920 0.00480371578608247 0.00591922834256394 1920 3029.90909090909 2887 0.000437657900925572 1079 0.49227174192176 -0.49227174192176 -1 1.01797584175464 1916 4138 2887 4499 4075 1079 1756 2098 4623 4451 1807 2970 M14198 GO_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MIGRATION.html The movement of a T cell within or between different tissues and organs of the body. 6/27 Gene Ontology BP GO:0072678 0.00058583981789863 0.000790024477055863 2145 2718.81818181818 2888 5.85994318958035e-05 734 2.59336136913912 2.59336136913912 1 7.4683434756804 2145 3807 4202 2888 4565 1784 734 1263 3471 3445 1603 2971 M16171 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 9/20 Gene Ontology BP GO:0090005 0.000479936334118649 0.000654625264192975 2000 2879 2888 4.80040018133959e-05 689 1.05456078696816 -1.05456078696816 -1 3.11684193607357 1998 2835 4522 3335 4305 689 1599 2888 4332 3760 1406 2972 M13018 GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. 8/28 Gene Ontology BP GO:0045672 0.000213832317140607 0.000302874755486223 1915 2796 2889 2.13852895844511e-05 1912 1.42160581109884 -1.42160581109884 -1 4.64338946269863 2091 3357 3993 2889 3163 2048 3421 1912 3838 2132 1912 2973 M13689 GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex assembly. 218/505 Gene Ontology BP GO:0043254 2.63917100097034e-08 1.25141295963921e-07 3525 2800.81818181818 2889 2.3992463933004e-09 861 1.35999199274297 -0.977645505884393 -1 8.71401192215372 3522 2033 2889 1791 861 2622 3362 2964 2276 3980 4509 2974 M12222 GO_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JAK_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. 55/201 Gene Ontology BP GO:0046425 2.82989172292724e-07 7.57084420689992e-07 3115 2807.81818181818 2890 2.57262916994577e-08 1667 1.51354889914212 1.74853255733503 1 8.59958966098712 3115 2909 1883 2890 1667 4163 3072 2080 2644 2564 3899 2975 M15781 GO_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 23/56 Gene Ontology BP GO:0046686 1.2941973870771e-05 2.20108368798498e-05 3645 3007 2890 1.17655000048609e-06 1593 1.94888670944181 -1.74401722664758 -1 8.42550335309893 3642 3341 2005 2284 2635 4383 2754 2890 1593 2994 4556 2976 M15845 GO_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of STAT cascade. 55/201 Gene Ontology BP GO:1904892 2.82989172292724e-07 7.57084420689992e-07 3120 2801.81818181818 2891 2.57262916994577e-08 1668 1.51354889914212 1.74853255733503 1 8.59958966098712 3116 2910 1884 2891 1668 4164 3073 2003 2645 2566 3900 2977 M14627 GO_CERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. 40/80 Gene Ontology BP GO:0006672 1.25308853178235e-06 2.7136614053477e-06 4095 3132.36363636364 2892 1.13917204138566e-07 1373 1.22585101220684 -1.11300312677368 -1 6.33409669958488 4091 1373 2541 2150 2076 3799 4091 4621 2892 2425 4397 2978 M14097 GO_VIRION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRION_ASSEMBLY.html A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. 24/47 Gene Ontology BP GO:0019068 2.49854204916839e-05 4.04206645794035e-05 1680 2599.81818181818 2893 2.27142765962263e-06 289 1.17866675512276 -0.732912059273518 -1 4.80684991972131 1680 3577 2612 4330 3599 289 1306 2893 3651 3493 1168 2979 M15322 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein. 9/31 Gene Ontology BP GO:0042522 0.000650564682261367 0.000872997635762869 2895 2462.45454545455 2893 6.50755216253297e-05 1172 1.09749197399998 1.18703037755625 1 3.11636335221722 1568 2894 4385 2893 3309 1404 1375 1380 3619 3088 1172 2980 M12463 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. 6/12 Gene Ontology BP GO:0032096 4.10616942040552e-05 6.39119833018533e-05 2655 2994.45454545455 2894 4.1062452952016e-06 1744 1.70834390519069 1.70834390519069 1 6.65144661057349 2655 2575 3911 3284 2894 3440 2771 3610 1744 3428 2627 2981 M15937 GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. 14/21 Gene Ontology BP GO:0043162 0.00364002782647268 0.0045346523204488 2590 2887 2894 0.000331460404706383 1004 0.875319705118603 -0.629894984611161 -1 1.90411250794414 2588 3525 2894 3808 4449 1004 1719 1738 4380 3978 1674 2982 M14343 GO_CELLULAR_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 32/117 Gene Ontology BP GO:0071398 1.71218693049505e-06 3.55055110240666e-06 1910 2824.54545454545 2895 1.55653478457702e-07 1781 1.52116918440743 1.34318694317991 1 7.69519416613172 1909 2750 1781 3004 2163 3254 2668 3727 3639 2895 3280 2983 M14499 GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 70/172 Gene Ontology BP GO:0044262 2.41962462355716e-07 6.65146070288685e-07 2895 3059.81818181818 2895 2.19965899061329e-08 1621 1.36233973578808 -0.975366233191554 -1 7.8115639001418 2895 3654 2380 3776 1621 4604 2545 2314 2830 3170 3869 2984 M15702 GO_NEGATIVE_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APPETITE.html Any process that reduces appetite. 6/12 Gene Ontology BP GO:0032099 4.10616942040552e-05 6.39119833018533e-05 2660 3044.90909090909 2895 4.1062452952016e-06 1745 1.70834390519069 1.70834390519069 1 6.65144661057349 2656 2576 4442 3285 2895 3441 2772 3599 1745 3455 2628 2985 M16568 GO_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_AGING.html Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 28/53 Gene Ontology BP GO:0090342 8.19748699102129e-06 1.44828508749284e-05 4390 3068.27272727273 2896 7.45228866916957e-07 2125 1.37437532548151 -0.935741154805266 -1 6.17366695654359 4389 3634 2336 3172 2540 2896 3688 2629 2125 3706 2636 2986 M12049 GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of endothelial cell development. 7/14 Gene Ontology BP GO:1901550 0.0615740388901874 0.0690230401712196 2760 3104.63636363636 2898 0.00633498053439465 2210 1.75022081368347 -1.75022081368347 -1 1.88623748867982 2757 2898 3843 2210 4486 2616 3291 3786 3186 2721 2357 2987 M14578 GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. 7/14 Gene Ontology BP GO:1903140 0.0615740388901874 0.0690230401712196 2760 3144.63636363636 2899 0.00633498053439465 2211 1.75022081368347 -1.75022081368347 -1 1.88623748867982 2758 2899 4251 2211 4487 2617 3292 3787 3187 2744 2358 2988 M10092 GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. 8/22 Gene Ontology BP GO:0050855 2.96434888211463e-05 4.73948755497872e-05 1945 2573.81818181818 2900 2.96438842599636e-06 555 1.63103390723521 1.63103390723521 1 6.54703679530541 1943 3876 3530 3807 4188 2009 669 1067 3768 2900 555 2989 M13391 GO_VITAMIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 6/24 Gene Ontology BP GO:0009110 0.0175154146473664 0.0205727473330944 2420 2940.36363636364 2901 0.00176550212137329 1984 1.02092087577198 -1.02092087577198 -1 1.59845715789114 2417 2901 4066 3277 3937 2097 2061 2483 3684 3437 1984 2990 M11488 GO_MICROTUBULE_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_NUCLEATION.html The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). 6/24 Gene Ontology BP GO:0007020 0.00150625117688627 0.00194859966962468 995 2634.27272727273 2902 0.000150727310857554 994 0.661644568467725 -0.661644568467725 -1 1.66459114672763 1781 2902 3757 3099 3413 994 995 1952 4155 4370 1559 2991 M13168 GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 133/292 Gene Ontology BP GO:0009141 1.1986419115688e-06 2.6066952671728e-06 1045 2490.45454545455 2902 1.08967505875822e-07 942 1.16672798110542 -0.855423975779985 -1 6.04751745335022 1041 2966 3317 3311 2061 942 1650 3063 2902 4160 1982 2992 M10072 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY.html Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 66/138 Gene Ontology BP GO:0090175 3.96661578604074e-06 7.47443063903699e-06 2800 3093.72727272727 2903 3.60602085263229e-07 2382 1.26142400627994 1.56408695569867 1 6.00267131169683 2800 2459 3181 2534 2382 3697 4005 2903 2793 3479 3798 2993 M12523 GO_L_ASCORBIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 9/12 Gene Ontology BP GO:0019852 0.000231646826722754 0.000326414633224203 2345 2769 2903 2.31670977379513e-05 1759 1.53273413651699 1.64299142505262 1 4.96011833259577 2344 1759 3923 2903 3178 3458 2396 2081 2239 3077 3101 2994 M15794 GO_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. 19/61 Gene Ontology BP GO:0030850 4.67073779705459e-05 7.2047294324666e-05 4490 2890 2903 4.24621542062822e-06 1032 2.57048272319933 -2.31468804484127 -1 9.8840288058999 4487 4009 1656 2804 2903 3788 3132 2489 1032 2062 3428 2995 M16914 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. 8/23 Gene Ontology BP GO:2000651 1.55705721001015e-06 3.28013458533444e-06 2905 2765.36363636364 2903 1.55705830100345e-07 708 2.46614014367044 -2.35272800456759 -1 12.5543118803254 2903 2108 4636 1517 2164 4037 3358 3817 708 2155 3016 2996 M11761 GO_AXON_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_REGENERATION.html The regrowth of axons following their loss or damage. 12/34 Gene Ontology BP GO:0031103 4.71547833023181e-05 7.26891297718004e-05 3195 2700.27272727273 2905 4.28689036799233e-06 1168 1.50455404555699 -1.4098116127357 -1 5.77993671212203 3195 1254 1819 1703 2905 4372 3508 3855 2370 1168 3554 2997 M12817 GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. 121/342 Gene Ontology BP GO:0050714 5.04883773232417e-06 9.31337051695714e-06 2930 2667.72727272727 2905 4.58986301733782e-07 704 1.76616046725777 1.99137279849679 1 8.24791889891289 2926 2905 925 2933 2436 4167 2893 2733 2910 704 3813 2998 M13155 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. 30/55 Gene Ontology BP GO:0034502 0.0412117655131728 0.0468985851170738 4415 3116.63636363636 2905 0.00381860393431905 1859 1.78723647325469 -1.78723647325469 -1 2.2045700251244 1890 4415 2905 3616 4414 1859 2505 2290 4098 4082 2209 2999 M13338 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleotide across a membrane. 7/13 Gene Ontology BP GO:1901679 0.000384687144846124 0.000530315443444344 4285 3003.18181818182 2906 3.84753753964756e-05 1761 1.32142585175117 -1.38226621370995 -1 4.01776913770076 4283 1761 4054 2813 3236 3233 4338 2029 2414 1968 2906 3000 M14848 GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING.html Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 7/17 Gene Ontology BP GO:0090036 4.63204420817074e-07 1.13972343712436e-06 4050 2994.18181818182 2906 4.63204517368354e-08 1420 1.64047036889063 -1.66869001456808 -1 9.05019436139508 4048 1420 4304 1676 1843 4409 3590 2906 2395 1976 4369 3001 M11065 GO_PRIMITIVE_STREAK_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMITIVE_STREAK_FORMATION.html The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. 8/19 Gene Ontology BP GO:0090009 1.98624020296547e-06 4.02536589365721e-06 2630 2962 2907 1.98624197828526e-07 2241 1.38423058047231 1.20301264113701 1 6.93241711636696 2627 3460 3681 2427 2241 2980 2402 3274 3718 2907 2865 3002 M11576 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. 8/16 Gene Ontology BP GO:1904406 0.00364905852906505 0.00454346440076402 2395 2811.36363636364 2907 0.000365506444648166 1867 1.43848390360396 1.88515714360948 1 3.12805690817429 2391 1926 3771 3396 3533 2907 1867 2784 3297 2125 2928 3003 M10362 GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. 93/198 Gene Ontology BP GO:0032434 8.23546917758273e-07 1.87345827493957e-06 2910 2675.18181818182 2908 7.48679296404166e-08 573 1.15297166866861 -1.24082357716246 -1 6.12973839941715 2908 3625 3299 3985 1973 573 2578 2207 3499 4039 741 3004 M12164 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 8/16 Gene Ontology BP GO:0045019 0.00364905852906505 0.00454346440076402 2395 2822.81818181818 2908 0.000365506444648166 1868 1.43848390360396 1.88515714360948 1 3.12805690817429 2392 1927 3862 3397 3534 2908 1868 2806 3298 2130 2929 3005 M11081 GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY.html The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. 15/35 Gene Ontology BP GO:0007250 4.75628570803181e-05 7.32452223628249e-05 3745 2830.54545454545 2909 4.32398958142757e-06 1519 1.84708536389421 -0.979375065733409 -1 7.09013965733106 3741 3345 1852 1519 2909 4138 4082 2198 1787 2601 2964 3006 M12568 GO_NOSE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOSE_DEVELOPMENT.html The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). 5/29 Gene Ontology BP GO:0043584 0.0011875428616493 0.0015518608237089 2510 2767.81818181818 2909 0.000118817795548377 1256 2.11532840688171 -2.11532840688171 -1 5.51596408060714 2509 3135 3933 2909 3461 1836 2896 1595 3641 3275 1256 3007 M13177 GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION.html A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. 9/20 Gene Ontology BP GO:0014829 0.000101850655622063 0.000149602212607794 3000 2694.09090909091 2909 1.01855324023425e-05 622 4.69221782805636 5.3730444617881 1 16.6604136224047 2999 2404 4029 1062 3046 3897 3556 2763 622 2348 2909 3008 M10109 GO_ATP_DEPENDENT_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. 45/200 Gene Ontology BP GO:0043044 3.33080970479842e-05 5.27813974722835e-05 3740 2983.09090909091 2910 3.0280546677029e-06 1433 2.49136756074171 -1.76860505774092 -1 9.89233687879643 3210 4331 1433 2910 2831 2819 3903 3737 1785 2118 3737 3009 M14496 GO_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 18/38 Gene Ontology BP GO:0001935 6.5484361059221e-07 1.53557519392911e-06 3455 2716.72727272727 2910 5.95312550464129e-08 1445 1.55974743322828 -1.96919856477519 -1 8.41740432153445 3452 1856 1445 3459 1905 3053 4492 2872 2963 1477 2910 3010 M14903 GO_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_SLEEP.html Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. 7/36 Gene Ontology BP GO:0030431 0.000570552520534597 0.000771200976082135 2845 2679 2910 5.70699062070551e-05 214 2.04614267344445 -0.328789034457426 -1 5.91235880696443 2845 2411 4313 1494 3285 4122 3119 2910 214 3573 1183 3011 M10044 GO_TRNA_AMINOACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_AMINOACYLATION.html The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. 33/52 Gene Ontology BP GO:0043039 0.00132049755590232 0.00171786779267427 625 2572.27272727273 2912 0.000120117347250438 624 0.6872789746872 -0.6872789746872 -1 1.76400128738591 624 2912 3386 3587 3594 837 1600 1796 4037 4300 1622 3012 M10357 GO_AMINO_ACID_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_ACTIVATION.html The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. 33/52 Gene Ontology BP GO:0043038 0.00132049755590232 0.00171786779267427 625 2576.45454545455 2913 0.000120117347250438 625 0.6872789746872 -0.6872789746872 -1 1.76400128738591 625 2913 3387 3588 3595 838 1601 1819 4038 4314 1623 3013 M10718 GO_DENDRITIC_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_CHEMOTAXIS.html The movement of a dendritic cell in response to an external stimulus. 5/38 Gene Ontology BP GO:0002407 0.0044376982704462 0.00548130701507893 2085 3016.63636363636 2913 0.000444658518234444 1008 2.31268756327117 2.31268756327117 1 4.85410210587146 2081 4465 3624 4044 4113 2334 1008 2594 3747 2260 2913 3014 M10908 GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE.html The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. 8/15 Gene Ontology BP GO:0016254 6.63983932624549e-05 9.99635991950643e-05 2640 2955.72727272727 2915 6.64003772818706e-06 2111 0.666597437662007 -0.666597437662007 -1 2.47519776710096 2639 2486 3657 3398 2983 2111 2915 2583 3159 4340 2242 3015 M10897 GO_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 26/54 Gene Ontology BP GO:0090311 4.97709090942955e-05 7.64427161511127e-05 2920 3009.36363636364 2917 4.52473046402075e-06 1401 1.39836779449582 -1.02343438662072 -1 5.3436247031915 3347 2819 2455 2251 2917 4446 2909 2920 1401 3237 4401 3016 M12102 GO_CELLULAR_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 8/23 Gene Ontology BP GO:0071318 1.39106983894762e-05 2.35119667354708e-05 1635 2363.72727272727 2917 1.39107854686318e-06 189 2.30684402490918 2.30684402490918 1 9.91168369296682 1634 4350 3849 3160 3775 1159 189 1601 2922 2917 445 3017 M13548 GO_BLASTOCYST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_DEVELOPMENT.html The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. 28/76 Gene Ontology BP GO:0001824 4.06638450922762e-05 6.33564539474625e-05 2835 2768.27272727273 2918 3.69678152041716e-06 1005 1.08648647011754 -1.24818046493634 -1 4.23406492730108 2832 3659 2918 3485 2877 1005 2485 3038 3700 3370 1082 3018 M13999 GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION.html The modification of peptidyl-glutamic acid. 12/35 Gene Ontology BP GO:0018200 5.00723925366708e-05 7.68549152224008e-05 2750 3065.36363636364 2918 4.5521392935977e-06 2530 1.18535515323259 -1.37954093950876 -1 4.52706326014118 2748 3011 2530 3863 2918 2629 2640 3231 3387 3900 2862 3019 M11974 GO_PSEUDOURIDINE_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHESIS.html The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. 10/17 Gene Ontology BP GO:0001522 0.000905597548097816 0.00119621320506918 1730 2760.36363636364 2919 8.23609580853179e-05 1652 0.779528450067674 -0.779528450067674 -1 2.11450993423424 1730 3095 3135 2919 3344 1652 2206 2148 3505 4389 2241 3020 M11577 GO_VENTRICULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. 21/67 Gene Ontology BP GO:0021591 3.24334569918112e-05 5.15184881330754e-05 4090 2820.63636363636 2920 2.9485395592078e-06 495 2.52407493378091 3.79046624687581 1 10.0468493538877 4086 3551 2008 2164 4164 2920 4520 746 495 3947 2426 3021 M13110 GO_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_PRODUCTION.html The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. 8/36 Gene Ontology BP GO:0032609 0.00342839910218151 0.00428480673793506 1820 2876.45454545455 2920 0.000343369987966809 1396 1.32538703285533 -1.32538703285533 -1 2.91344039874866 1816 3562 4015 3593 4048 1396 2012 2597 4157 2920 1525 3022 M15067 GO_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that modulates the frequency, rate or extent of translational initiation. 42/99 Gene Ontology BP GO:0006446 6.0025762781403e-06 1.089521566044e-05 2920 3154.09090909091 2920 5.4569024144497e-07 1484 1.19098756678283 -0.826523868758174 -1 5.48655821712521 2920 4193 3254 3913 2475 1484 2878 4454 2818 3959 2347 3023 M12182 GO_BIOTIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOTIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. 6/13 Gene Ontology BP GO:0006768 3.95903957163961e-05 6.193171979426e-05 2925 3066 2921 3.95911010638268e-06 2247 0.972048878713404 -1.30013810008081 -1 3.7970115494402 2921 2247 3865 3197 2887 2412 2596 2810 4333 3425 3033 3024 M16572 GO_LYSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. 6/16 Gene Ontology BP GO:0006553 9.50849084356568e-08 3.14892460675288e-07 3995 2557 2922 9.50849125041697e-09 417 1.55453248642629 -2.45144112982884 -1 9.38220811042198 3995 1188 4583 1655 1351 4524 2922 417 878 3462 3152 3025 M14771 GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a steroid hormone binding to a receptor. 58/224 Gene Ontology BP GO:0043401 6.8689596205109e-06 1.23137372656495e-05 4475 2906.45454545455 2923 6.24452824294896e-07 1277 1.86054028200561 1.82676856998595 1 8.47920654274402 4474 3362 1563 1989 2503 2923 4321 4537 1277 1892 3130 3026 M15560 GO_EPITHELIAL_STRUCTURE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_STRUCTURE_MAINTENANCE.html A tissue homeostatic process required for the maintenance of epithelial structure. 13/49 Gene Ontology BP GO:0010669 0.00753103659919666 0.00911538136863141 2720 2892.45454545455 2923 0.000686994642177218 1968 2.07893360908792 2.44754944404177 1 3.93720328095002 2718 3526 1968 2876 3611 3655 3052 3152 2019 2317 2923 3027 M14410 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 16/50 Gene Ontology BP GO:0045078 5.15335553794115e-05 7.89410417771717e-05 3570 2971.81818181818 2924 4.68497841442686e-06 2000 1.39109790982014 -1.48236659459435 -1 5.29780883127588 3569 2688 2668 3114 2924 2509 4044 2000 3356 3258 2560 3028 M10894 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. 29/59 Gene Ontology BP GO:2000378 5.16649331535341e-05 7.91079767317817e-05 2885 2648.45454545455 2925 4.69692240871303e-06 1380 1.37868364492789 -1.06285594825309 -1 5.24935667911196 2882 1380 1721 2934 2925 4022 1806 3521 3128 1535 3279 3029 M10910 GO_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROTIC_CELL_DEATH.html A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. 27/55 Gene Ontology BP GO:0070265 4.19442593738348e-06 7.8527095271256e-06 4085 3208.72727272727 2927 3.8131217584709e-07 1539 1.29123097239887 -1.13067532518417 -1 6.11881252880205 4083 1539 2589 2140 2396 3791 3870 4614 2927 2881 4466 3030 M14291 GO_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_CHEMOTAXIS.html The movement of a macrophage in response to an external stimulus. 8/17 Gene Ontology BP GO:0048246 0.00348891405857831 0.00435574831244396 2825 3173.54545454545 2928 0.000349440382749722 2243 3.06684722467499 -3.06684722467499 -1 6.72118285011082 2823 4080 4220 3702 3524 2519 3447 2715 2243 2928 2708 3031 M12196 GO_BASE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASE_EXCISION_REPAIR.html In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. 24/43 Gene Ontology BP GO:0006284 0.0503090338712993 0.0568056527880453 2010 3021.18181818182 2929 0.00468161112781469 1326 1.20491347938223 -0.650563367963186 -1 1.39317760796478 2010 3925 2929 3238 3795 1997 2722 4516 1326 4000 2775 3032 M15849 GO_DORSAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. 9/28 Gene Ontology BP GO:0021516 4.72447681049291e-05 7.28036701995306e-05 4525 3160.18181818182 2929 4.72457725656353e-06 1668 1.84401366981394 -2.56061244850538 -1 7.08284381947647 4525 1925 4466 2307 2929 4170 3513 4293 2075 1668 2891 3033 M15519 GO_CELLULAR_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. 10/17 Gene Ontology BP GO:0006878 0.0839184282471183 0.0891201423493528 3240 2811.27272727273 2931 0.00793650793650794 864 0.935716682602831 -0.856135511195647 -1 0.912037502052223 3238 864 2609 1285 3998 3781 3405 2931 2315 2496 4002 3034 M11006 GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. 10/18 Gene Ontology BP GO:0009208 0.000376491634705925 0.000519789075212492 1395 2489.90909090909 2932 3.42323709203978e-05 894 0.865695935956356 -0.865695935956356 -1 2.63912824221511 1393 2932 2943 4380 3223 894 1038 1448 3743 3794 1601 3035 M14347 GO_REGULATION_OF_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. 44/107 Gene Ontology BP GO:0006885 5.27898247205106e-05 8.06525686664464e-05 3970 3088.36363636364 2933 4.79919013406356e-06 2124 1.53064060015275 -1.20756845049302 -1 5.81600283701087 3968 2261 2124 2737 2933 2799 4608 3917 3123 2402 3100 3036 M13701 GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of B cell apoptotic process. 13/27 Gene Ontology BP GO:0002902 0.00375074997283669 0.00466757762634166 2055 2888.18181818182 2934 0.000341559989084358 1830 1.47857758546977 1.57374808414522 1 3.19917832835561 2055 3554 2597 3356 3520 3474 2934 1830 3688 2307 2455 3037 M14847 GO_DETERMINATION_OF_ADULT_LIFESPAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETERMINATION_OF_ADULT_LIFESPAN.html The control of viability and duration in the adult phase of the life-cycle. 9/19 Gene Ontology BP GO:0008340 0.000137185626218201 0.000198119086323828 2685 2927.72727272727 2934 1.37194095907311e-05 805 2.6610813278189 3.24870175150456 1 9.14723073061532 2682 2934 4303 2015 3094 4020 3995 2534 805 2359 3464 3038 M12539 GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. 79/222 Gene Ontology BP GO:0071346 5.29945959266321e-05 8.09121699728223e-05 2250 2967.36363636364 2935 4.8178065934092e-06 1438 1.61779998446058 1.95818891040262 1 6.14508804906755 2248 4255 1945 3910 2935 3830 2395 1438 3567 2621 3497 3039 M14895 GO_CELL_MIGRATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_IN_HINDBRAIN.html The orderly movement of a cell that will reside in the hindbrain. 5/24 Gene Ontology BP GO:0021535 0.00216668807948502 0.00275312883225204 1435 2593.63636363636 2935 0.000216880352470707 850 1.01872351552063 1.01872351552063 1 2.4210002204129 1434 3196 4311 2935 3567 1301 850 1981 3728 3290 1937 3040 M12973 GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. 6/13 Gene Ontology BP GO:0060576 3.80994119772952e-05 5.97418337759478e-05 3450 2908.18181818182 2936 3.8100065197394e-06 1272 2.14682646247219 1.72192072622306 1 8.41707779022269 3446 2936 3987 1272 2881 3683 2816 3085 1656 1727 4501 3041 M15994 GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 87/233 Gene Ontology BP GO:0043902 3.5308709858184e-07 9.12796992603276e-07 3870 3125 2937 3.20988322954783e-08 1723 1.589521879578 -1.25044204684026 -1 8.91139458806773 3869 3743 2345 2937 1723 2770 3396 2729 2868 3633 4362 3042 M10224 GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of cell cycle checkpoint. 24/42 Gene Ontology BP GO:1901976 2.66806644477952e-07 7.22744020018162e-07 2195 2617.09090909091 2938 2.42551524395575e-08 1185 1.12579263497067 -1.18626735059873 -1 6.41752729736756 2194 3979 3044 2938 1649 1185 2266 3344 3462 3491 1236 3043 M12786 GO_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FISSION.html The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 7/15 Gene Ontology BP GO:0000266 0.0211002898297786 0.0245720204864966 2940 3198.90909090909 2938 0.00213033588580576 1928 0.54322806981048 -0.563955850675196 -1 0.811630151139289 2525 1928 3959 3778 3714 2329 2509 2937 4140 4431 2938 3044 M15885 GO_NAD_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. 8/16 Gene Ontology BP GO:0009435 0.000259368789400448 0.000363492088495708 2685 2962.54545454545 2938 2.59399066850161e-05 1682 1.22212070037313 -1.28290893413951 -1 3.90192726598245 2681 2023 4473 3078 3192 1682 1999 4483 3243 2938 2796 3045 M16149 GO_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. 418/971 Gene Ontology BP GO:0032386 8.75717200592452e-09 6.37297016042438e-08 2530 2760.72727272727 2938 7.96106549162068e-10 429 1.43194714598187 -1.1309056600519 -1 9.56459624930707 2938 2996 2528 3318 429 2530 3031 2702 2712 3147 4037 3046 M15452 GO_MONOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 103/276 Gene Ontology BP GO:0005996 2.54064144853944e-07 6.94711321882723e-07 3705 2698.27272727273 2940 2.30967431085652e-08 1165 1.42172314066727 -1.15594007699775 -1 8.1271381899298 3703 2940 2204 2967 1632 1165 3224 3913 2525 2423 2985 3047 M16085 GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. 8/36 Gene Ontology BP GO:0048486 0.0296557572626339 0.0341412548897617 2410 3119.09090909091 2941 0.00300591127724086 2407 1.34459766683526 -0.817055237582534 -1 1.83066473339223 2407 2669 4505 2485 3747 3277 2871 3426 2689 2941 3293 3048 M10533 GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 21/84 Gene Ontology BP GO:0090207 3.63716026292366e-05 5.71483421345332e-05 3765 3053.09090909091 2944 3.30656399621564e-06 1560 1.74817805070166 -1.5840449974986 -1 6.88537268191456 3763 2655 1560 3501 2852 2488 3762 4182 3643 2234 2944 3049 M10958 GO_TRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. 103/180 Gene Ontology BP GO:0006399 5.70594032511107e-05 8.68043280782788e-05 575 2793.36363636364 2944 5.18735301843664e-06 574 0.746649264303521 -0.759734556467347 -1 2.81493120292708 574 3386 3485 4405 2944 1227 2253 2215 4019 4258 1961 3050 M11565 GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 32/95 Gene Ontology BP GO:0051196 1.30416035124966e-05 2.21559330803227e-05 2945 3126.72727272727 2944 1.18560734761679e-06 2384 1.20559046810934 -1.00661235041252 -1 5.20886251216945 2933 2945 2458 2944 2637 4587 3399 2384 3721 2892 3494 3051 M10074 GO_FOREBRAIN_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. 16/71 Gene Ontology BP GO:0021884 0.00630132170631179 0.00767498338992803 4490 3036.90909090909 2945 0.000574494808405277 1258 1.68284178631794 -1.54849033882489 -1 3.30374768492041 4489 2924 1886 2377 3593 3878 3861 2945 2237 1258 3958 3052 M15443 GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 32/95 Gene Ontology BP GO:0051193 1.30416035124966e-05 2.21559330803227e-05 2935 3131.18181818182 2945 1.18560734761679e-06 2420 1.20559046810934 -1.00661235041252 -1 5.20886251216945 2934 2946 2459 2945 2638 4588 3400 2420 3722 2896 3495 3053 M11770 GO_POSITIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BINDING.html Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 36/70 Gene Ontology BP GO:0043388 3.76415591872372e-06 7.12183208257304e-06 4105 2896.36363636364 2946 3.42196578103137e-07 1788 1.28059133396806 -0.953923409074406 -1 6.1188288021004 4101 1788 2571 1862 2374 2059 3654 4307 2946 3228 2970 3054 M13877 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS.html The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. 36/110 Gene Ontology BP GO:0017156 3.59065828141708e-06 6.81579166010609e-06 3190 2860.36363636364 2946 3.26424012891484e-07 1044 1.2719718195794 -1.09324320664058 -1 6.10016637955671 3190 1044 2379 2566 2364 3768 2946 4238 3075 1437 4457 3055 M16854 GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY.html Any process that modulates the activity of the enzyme protein phosphatase type 2A. 10/25 Gene Ontology BP GO:0034047 0.00369511358937852 0.00459957436876259 4135 2899 2947 0.000336484956768148 130 1.2780289226475 -0.457351192113128 -1 2.7728154996437 4135 2481 2688 1959 3518 2435 2947 3203 130 3826 4567 3056 M10984 GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 67/163 Gene Ontology BP GO:0007249 5.2123386802799e-07 1.25849654147372e-06 2315 2878.36363636364 2948 4.73849083200998e-08 901 0.985136160663614 -0.957154974063878 -1 5.39545767771995 2312 3601 3325 4554 1849 901 2948 2799 3854 4093 1426 3057 M11659 GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 17/33 Gene Ontology BP GO:0046134 0.0839184282471183 0.0891201423493528 1805 3117.18181818182 2949 0.00793650793650794 1805 0.997095009830152 -0.997095009830152 -1 0.971862607021511 1805 3448 2762 4332 4005 1983 2394 2949 4058 4026 2527 3058 M10943 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html The directed movement of a protein to a specific location on a chromosome. 11/20 Gene Ontology BP GO:0070199 0.00173873217371508 0.00223565036902773 2160 2955.09090909091 2950 0.000158191624836241 1474 1.9451145103418 -1.9451145103418 -1 4.78583646452118 2156 4203 2950 3131 4073 1711 2489 1474 4147 3854 2318 3059 M11550 GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. 2/15 Gene Ontology BP GO:0021521 4.24205363744114e-05 6.58283925088208e-05 3385 2664.3 2950 4.71348179715539e-06 448 1.45108638874357 -1.0605218207371 -1 5.6325299010958 3384 1579 3767 NA 2927 3912 2694 3595 448 1364 2973 3060 M12806 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. 15/43 Gene Ontology BP GO:0051769 5.99499072483127e-05 9.090379469429e-05 2370 3037.27272727273 2951 5.45014008573486e-06 1993 1.04751227974855 1.27126397927942 1 3.92972366826411 2369 3823 2656 3310 2951 2826 2246 3461 4088 3687 1993 3061 M14635 GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. 14/38 Gene Ontology BP GO:0002367 0.000118635047760055 0.000172671638479603 2630 2978.36363636364 2951 1.07855859673267e-05 2437 1.232917261725 1.58869707571896 1 4.30637420249071 2630 2559 2437 2951 3059 3351 3498 2565 2918 3044 3750 3062 M15625 GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION.html The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. 2/15 Gene Ontology BP GO:0060573 4.24205363744114e-05 6.58283925088208e-05 3385 2731.6 2951 4.71348179715539e-06 449 1.45108638874357 -1.0605218207371 -1 5.6325299010958 3385 1580 4432 NA 2928 3913 2695 3594 449 1366 2974 3063 M16555 GO_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING.html Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 28/70 Gene Ontology BP GO:0060968 0.0839184282471183 0.0891201423493528 2230 3280.90909090909 2953 0.00793650793650794 1966 1.09497757915552 -1.16264411490711 -1 1.06726818825975 2230 4412 2953 4423 4003 1966 2839 2704 4045 4059 2456 3064 M12267 GO_ECTODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. 15/39 Gene Ontology BP GO:0007398 2.01743164288209e-07 5.68313067791795e-07 1840 2773.81818181818 2954 1.83402893443955e-08 1576 2.40153290416599 2.66269583464782 1 13.9225502986924 3215 2954 1839 2195 1576 4621 3650 3201 1839 2039 3383 3065 M11179 GO_BONE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 14/29 Gene Ontology BP GO:0098751 1.17928317709918e-06 2.57424155678021e-06 2870 3096.63636363636 2955 1.07207619021821e-07 2053 1.02751848463323 1.1759433551434 1 5.33114051137334 2866 2955 2858 2711 2053 3829 3818 2173 3601 3607 3592 3066 M15915 GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. 28/101 Gene Ontology BP GO:0002715 6.22099627296785e-05 9.39931197376822e-05 4530 3033.09090909091 2955 5.65561108421371e-06 1566 1.77346860178264 -1.13155530462565 -1 6.62924244239041 4528 2177 1566 2512 2955 3777 4249 3032 2413 2116 4039 3067 M13902 GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of erythrocyte differentiation. 27/48 Gene Ontology BP GO:0045646 0.0839184282471183 0.0891201423493528 2960 3220.81818181818 2956 0.00793650793650794 2317 1.3671674316218 1.49273219606924 1 1.33257008277151 2956 2619 2317 2704 4570 4523 3315 2642 3530 2435 3818 3068 M10035 GO_LACTATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSPORT.html The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 4/13 Gene Ontology BP GO:0015727 0.025736521980375 0.0297620601631086 2960 3134.18181818182 2957 0.00260395387589323 2066 1.61879746918866 -1.38125031809021 -1 2.29357029510128 2957 2839 3521 2848 3731 3753 3874 2754 2586 2066 3547 3069 M10131 GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 30/65 Gene Ontology BP GO:0050854 2.53144857824087e-05 4.09102532153579e-05 2180 2694.09090909091 2957 2.30134337003359e-06 983 1.76322142041578 1.68232275927211 1 7.18222841232873 2180 3816 1643 3576 2776 2957 1767 3582 3394 983 2961 3070 M16351 GO_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_KILLING.html Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. 45/138 Gene Ontology BP GO:0031341 1.42765908224291e-05 2.40778100939115e-05 4135 3134.81818181818 2957 1.29788031538187e-06 1609 1.7907716372274 -1.33889208502645 -1 7.67713690390188 4131 2461 1609 2655 2662 3992 3122 4324 2957 2454 4116 3071 M13665 GO_LACTATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 4/13 Gene Ontology BP GO:0035873 0.025736521980375 0.0297620601631086 2960 3190.09090909091 2958 0.00260395387589323 2083 1.61879746918866 -1.38125031809021 -1 2.29357029510128 2958 2840 4112 2849 3732 3754 3875 2753 2587 2083 3548 3072 M11230 GO_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_VIRUS.html Reactions triggered in response to the presence of a virus that act to protect the cell or organism. 105/318 Gene Ontology BP GO:0051607 3.61925456409154e-09 4.0297839187235e-08 4475 3074.45454545455 2960 3.29023142731422e-10 137 1.32606418640739 -1.11975798093016 -1 9.10238727676193 4473 2675 2490 4379 137 2338 4417 4264 2960 2104 3582 3073 M13683 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. 13/18 Gene Ontology BP GO:1902165 9.39988109239866e-07 2.11001510518334e-06 3835 2856.45454545455 2960 8.54535009878462e-08 1287 1.13954987402511 -0.900216305312635 -1 6.00375555479462 3833 1326 2357 1287 1999 4139 4516 3421 2111 2960 3472 3074 M14359 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. 24/59 Gene Ontology BP GO:0060760 3.21699474305898e-06 6.18488885798047e-06 3160 2862.72727272727 2960 2.924544951986e-07 933 1.89499886473775 2.22373337028802 1 9.16230556476977 3157 3660 1920 933 2339 4312 3391 2960 2558 2619 3641 3075 M11459 GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. 10/32 Gene Ontology BP GO:0065005 1.48229573410824e-05 2.49087915072912e-05 3000 2791.09090909091 2961 1.34755065588918e-06 1484 1.44653531840307 2.08096642230198 1 6.1815902932169 2996 2961 2149 3703 2673 4483 3046 1525 1484 3191 2491 3076 M10563 GO_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that modulates the frequency, rate or extent of cellular senescence. 25/46 Gene Ontology BP GO:2000772 1.14968876991626e-05 1.9733844579376e-05 4585 3100.45454545455 2962 1.04517707097321e-06 2050 1.44593195312973 -0.981896505772911 -1 6.31476320047767 4581 3206 2127 2886 2616 3311 4413 2418 2050 3535 2962 3077 M14197 GO_CELLULAR_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 13/32 Gene Ontology BP GO:0036315 2.5392276077561e-07 6.94711321882723e-07 4305 2987 2963 2.30838900075671e-08 1631 2.21511633875618 -2.15979724816447 -1 12.6624911972304 4301 2633 1707 2521 1631 3348 4634 3128 2180 2963 3811 3078 M14656 GO_ENDOCYTIC_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_RECYCLING.html The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. 13/29 Gene Ontology BP GO:0032456 2.65622973583593e-07 7.19957656946073e-07 4430 3055.90909090909 2966 2.41475459685736e-08 1647 1.54173983182805 -1.22563115754017 -1 8.79101535949043 4430 1691 2160 2667 1647 3185 4297 4438 1931 2966 4203 3079 M14853 GO_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. 11/21 Gene Ontology BP GO:0030225 0.0595714620512039 0.0668900358654751 2255 3122.09090909091 2966 0.00556804213982602 2093 0.773232338339194 0.906574391394472 1 0.843108181420756 2251 3559 2966 3605 3824 2550 2093 2783 4203 3865 2644 3080 M11418 GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. 9/21 Gene Ontology BP GO:0019359 0.000118372678109117 0.000172451943665086 3070 2747.54545454545 2968 1.18378984022787e-05 1243 1.11320329336237 -1.14005039897333 -1 3.88880462451584 2319 2069 3742 2968 3066 1243 1691 4444 3251 3068 2362 3081 M13622 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 4/15 Gene Ontology BP GO:0010867 6.19447577636927e-05 9.36228874664144e-05 2810 3037.36363636364 2969 6.19464845502943e-06 2044 2.96294571455731 2.96294571455731 1 11.080233544898 2809 3104 4107 2856 2969 3869 3207 2044 2528 3119 2799 3082 M16385 GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. 9/21 Gene Ontology BP GO:0019363 0.000118372678109117 0.000172451943665086 2320 2824.54545454545 2969 1.18378984022787e-05 1244 1.11320329336237 -1.14005039897333 -1 3.88880462451584 2320 2070 4555 2969 3067 1244 1692 4443 3252 3095 2363 3083 M16917 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. 13/64 Gene Ontology BP GO:0045620 0.00179898879394033 0.0023099294718653 2265 2937.09090909091 2969 0.000163678323025836 2035 1.14887533078479 1.12771132889155 1 2.8115999617754 2263 3300 2358 3360 3422 2848 2035 2934 3842 2977 2969 3084 M11117 GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. 10/18 Gene Ontology BP GO:0045820 4.01233396465225e-06 7.54210947281519e-06 4005 3048 2970 3.64758298392558e-07 1861 1.2663583441486 -1.10389902789237 -1 6.02155030212485 4001 1870 1991 2970 2385 4146 4165 2564 3148 1861 4427 3085 M14564 GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 10/18 Gene Ontology BP GO:0051198 4.01233396465225e-06 7.54210947281519e-06 4005 3046.45454545455 2971 3.64758298392558e-07 1871 1.2663583441486 -1.10389902789237 -1 6.02155030212485 4002 1871 1992 2971 2386 4147 4166 2522 3149 1877 4428 3086 M16641 GO_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOLYSIS.html The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. 558/1543 Gene Ontology BP GO:0006508 5.937807319237e-09 5.11489936977357e-08 4350 2740.72727272727 2971 5.93780733510289e-10 162 1.55695164808273 -1.10905263560058 -1 10.5375842801635 4348 2766 4595 3774 318 162 4016 2971 2133 3384 1681 3087 M10951 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html The directed movement of a protein to a specific location. 792/1849 Gene Ontology BP GO:0045184 1.21633006462177e-07 3.83135718455828e-07 2665 2745.90909090909 2972 1.21633013119743e-08 110 1.37233632912842 -1.1097768309972 -1 8.1740608057303 2665 4065 3662 4421 1429 110 2972 3119 2662 4202 898 3088 M15248 GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 10/18 Gene Ontology BP GO:0051195 4.01233396465225e-06 7.54210947281519e-06 4005 3048.54545454545 2972 3.64758298392558e-07 1872 1.2663583441486 -1.10389902789237 -1 6.02155030212485 4003 1872 1993 2972 2387 4148 4167 2533 3150 1880 4429 3089 M12980 GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a symbiont organism effects a change in the structure or processes of its host organism. 32/81 Gene Ontology BP GO:0044003 2.11766781367542e-06 4.2508999822287e-06 2855 3030.72727272727 2974 1.92515441099543e-07 1970 1.68447188806969 2.2034623998443 1 8.39904725295502 2853 2974 1970 3420 2234 4072 3810 2860 3138 3298 2709 3090 M14263 GO_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APPETITE.html Any process which modulates appetite, the desire or physical craving for food. 10/23 Gene Ontology BP GO:0032098 0.0211272256762271 0.0245972188602613 2175 3035.63636363636 2975 0.00193935334865769 2173 1.90967974425188 1.90967974425188 1 2.85243965060343 2173 3281 2292 4195 3703 2953 2571 2902 3139 3208 2975 3091 M12015 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. 22/44 Gene Ontology BP GO:0002832 0.00198166819870465 0.0025291054003809 4080 3029.72727272727 2977 0.000180314132452406 1525 1.26983612234417 -0.939411700121135 -1 3.0612180853166 4080 2977 2719 2600 3437 2322 3799 3108 1525 2869 3891 3092 M16696 GO_CENTROSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_LOCALIZATION.html Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. 17/32 Gene Ontology BP GO:0051642 7.39135874641084e-06 1.318043776283e-05 2785 3087.27272727273 2978 6.71943961758055e-07 2041 1.34707645055302 1.57834360158691 1 6.10221405618567 2784 4265 2796 4551 2518 3315 2041 2353 2978 3366 2993 3093 M11419 GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. 15/39 Gene Ontology BP GO:0043508 1.33858337141592e-05 2.2707499428148e-05 3460 2837.63636363636 2980 1.21690137823226e-06 785 1.86907136746128 2.66737209258833 1 8.05696344017348 3456 2789 2136 2980 2644 4365 4168 806 785 3685 3400 3094 M13521 GO_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_REMODELING.html Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. 22/59 Gene Ontology BP GO:0046850 0.000100121394693656 0.000147295195045198 2235 2850.54545454545 2980 9.10235922555572e-06 1754 2.02450937528026 1.71443337657607 1 7.2010039587445 2234 3446 1754 3177 3031 3083 2084 4420 2749 2398 2980 3095 M15614 GO_PROTEIN_PALMITOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PALMITOYLATION.html The covalent attachment of a palmitoyl group to a protein. 12/26 Gene Ontology BP GO:0018345 0.000417678058468883 0.000573751250139355 2340 2936.63636363636 2980 3.79779433874147e-05 918 0.819975185196635 -0.892870273207017 -1 2.46709502225446 2338 3556 2980 4250 3924 918 2032 2703 4022 4580 1000 3096 M10938 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 49/136 Gene Ontology BP GO:0042993 7.04466348436056e-06 1.25946756095056e-05 2950 3135.72727272727 2982 6.4042600384708e-07 1823 1.49971666947099 -1.18805421388728 -1 6.82115400299736 2948 3715 2754 4282 2511 1823 3373 3996 2982 3628 2481 3097 M15127 GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that activates or increases the frequency, rate or extent of DNA recombination. 5/22 Gene Ontology BP GO:0045911 0.023844820903583 0.027677875863834 2985 3353 2982 0.0024104611846199 2339 0.828779327635385 -0.828779327635385 -1 1.19850106355607 2982 3437 4357 2887 3725 2339 2977 2621 4259 4551 2748 3098 M16053 GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION.html The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. 42/99 Gene Ontology BP GO:0035335 4.58285162417085e-07 1.13061530770591e-06 2700 3143.45454545455 2982 4.16622961711958e-08 1808 1.17930507856914 1.21822099549254 1 6.50983890989991 2697 2351 2519 3324 1808 4348 2511 4272 3468 2982 4298 3099 M11061 GO_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. 5/54 Gene Ontology BP GO:0042737 0.0765897756730953 0.0843068583333764 2965 3041.27272727273 2984 0.00793650793650794 1696 1.69867391400576 1.69867391400576 1 1.69370910517306 1696 2965 3680 2984 4225 2577 2149 3174 3769 3270 2965 3100 M13592 GO_HEART_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_FORMATION.html The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. 8/18 Gene Ontology BP GO:0060914 1.66144255226763e-07 4.91029775313724e-07 3520 2507.81818181818 2984 1.66144267648525e-08 238 2.11182886580046 -1.88958714096321 -1 12.367472736171 3517 238 4100 723 1531 3446 4276 4261 1863 647 2984 3101 M10793 GO_POSITIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BINDING.html Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 96/216 Gene Ontology BP GO:0051099 1.55737971774925e-08 8.85056796757623e-08 2570 3068.54545454545 2985 1.41579975343086e-09 663 1.26943443508393 1.62965208199655 1 8.31103416030572 2568 2967 2649 3914 663 4592 2856 2985 3239 3389 3932 3102 M11210 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 12/21 Gene Ontology BP GO:0009148 0.0839184282471183 0.0891201423493528 1960 3268.63636363636 2985 0.00793650793650794 1960 0.998917528314312 -0.998917528314312 -1 0.973639005378206 1960 4235 2985 4487 4047 2180 2601 2709 4059 3894 2798 3103 M13147 GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING.html Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. 4/19 Gene Ontology BP GO:0010738 0.00142048508645911 0.00184278073663863 2225 2627.09090909091 2986 0.000142139390422135 1122 1.41203924369362 1.41203924369362 1 3.58424753190436 2225 3227 4021 3158 3404 2357 1122 2986 1826 3117 1455 3104 M15126 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. 22/42 Gene Ontology BP GO:1901797 1.4003473655515e-07 4.26068992021992e-07 3485 2897.36363636364 2987 1.27304314062421e-08 953 0.972469325761669 -0.870485130633387 -1 5.75068959920766 3484 953 2547 2037 1446 4382 2763 3601 2987 3711 3960 3105 M16972 GO_AMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 9/24 Gene Ontology BP GO:0009309 2.70571145829145e-05 4.35597028462109e-05 4645 3138.18181818182 2987 2.70574440279122e-06 1462 0.677333721224165 0.619194481773884 1 2.74188628022792 1881 3376 4643 4316 2806 1991 1462 2987 3928 4643 2487 3106 M16007 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. 10/23 Gene Ontology BP GO:1903427 0.00181664618516764 0.0023306682060606 2990 2811.45454545455 2988 0.000165286183097965 1568 1.43344192404691 -0.981726704484338 -1 3.50284422272753 2988 1568 1927 3273 3423 3820 2450 2547 3259 1882 3789 3107 M13588 GO_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that modulates the frequency, rate or extent of muscle hypertrophy. 23/55 Gene Ontology BP GO:0014743 0.0115959758851164 0.0138370897030571 4565 3246.72727272727 2989 0.0010597774509439 1250 1.10404407156352 0.748224578029429 1 1.90512922660273 1837 4451 2989 4562 4564 1927 1250 2740 4392 4113 2889 3108 M13769 GO_MICROGLIAL_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROGLIAL_CELL_ACTIVATION.html The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 18/50 Gene Ontology BP GO:0001774 5.83296943733074e-05 8.85916817060079e-05 3560 3095.81818181818 2989 5.3028400868107e-06 2461 1.45900418294635 -1.56140883309011 -1 5.4885820275613 3560 3243 2537 3482 2948 2520 4066 2461 3557 2989 2691 3109 M14714 GO_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_HOMEOSTASIS.html Any process involved in the balance between food intake (energy input) and energy expenditure. 9/20 Gene Ontology BP GO:0097009 0.000762341607568994 0.00101565339567944 2295 2995.45454545455 2989 7.62603258033932e-05 1316 1.23560858149995 1.17806743324605 1 3.43315706670096 2293 2989 4280 4177 4270 2681 1528 1316 3658 3085 2673 3110 M13269 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 12/18 Gene Ontology BP GO:0010801 0.00121903388210169 0.00159211654419076 1450 2830.72727272727 2990 0.000110882716448307 1446 0.805224071179768 0.87989303091755 1 2.09140172564077 1446 3671 2990 3489 3375 1938 1929 2379 3901 3897 2123 3111 M13288 GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. 8/17 Gene Ontology BP GO:0030007 0.000532143588255011 0.000721174162366613 3180 2849.09090909091 2994 5.32271060777776e-05 1459 2.19375546547586 -3.29506164215868 -1 6.39820239491418 3179 3098 4044 2833 3277 2994 1484 1459 2324 2923 3725 3112 M13560 GO_BICARBONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSPORT.html The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 16/52 Gene Ontology BP GO:0015701 0.0251795730504473 0.0291543036591588 1825 2981.54545454545 2995 0.00231567852780169 1604 1.67186106536465 2.02476829593095 1 2.38265840300032 1823 3609 1604 3327 3724 2995 2599 4048 3759 2695 2614 3113 M13832 GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM.html A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. 129/471 Gene Ontology BP GO:0022412 9.53210774466411e-08 3.15329050019554e-07 4080 3153.90909090909 2995 8.66555287060821e-09 1317 1.49250902133105 -1.65091842943334 -1 9.00703872607841 4076 3974 2594 3298 1317 2631 4287 2984 2977 2995 3560 3114 M13837 GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 61/138 Gene Ontology BP GO:0033209 0.00472554228161227 0.00582599384320917 2715 3051.18181818182 2996 0.000430520295589045 1075 1.43941099115249 -1.05160993454995 -1 2.98579198516913 2715 3468 2941 3119 3559 1075 2516 4500 2996 3847 2827 3115 M14317 GO_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. 301/765 Gene Ontology BP GO:0005975 2.3585005831853e-08 1.16199757328007e-07 4605 2984.45454545455 2996 2.144091462245e-09 820 1.32041306607157 -1.04090025354313 -1 8.49987538371635 4527 2167 2602 3322 820 1086 4601 4605 2839 2996 3264 3116 M14225 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. 11/32 Gene Ontology BP GO:0002891 8.17741590366972e-05 0.000121574582263012 3000 2793.18181818182 2997 7.43429079511653e-06 1331 1.30396414749571 -1.25987497708414 -1 4.73897022609048 3881 1331 2249 1826 2999 3235 4307 2997 2567 2021 3312 3117 M11570 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. 11/32 Gene Ontology BP GO:0002714 8.17741590366972e-05 0.000121574582263012 3880 2792.27272727273 2998 7.43429079511653e-06 1330 1.30396414749571 -1.25987497708414 -1 4.73897022609048 3880 1330 2248 1825 2998 3234 4306 3008 2566 2009 3311 3118 M12991 GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. 24/68 Gene Ontology BP GO:0001914 0.0135838834957872 0.0161139425321768 2070 2802.72727272727 2998 0.00124258994088175 1736 1.43754441421564 -1.38790700960885 -1 2.39233382999016 2067 3267 2499 3305 3665 1736 2998 2517 3528 3050 2198 3119 M14089 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 17/43 Gene Ontology BP GO:0051024 0.00221170585188953 0.00280675068403353 3070 3066.54545454545 2998 0.000201266587304308 2063 1.54693290946798 -1.3410587620086 -1 3.66426249008786 3068 2824 2063 2998 3453 2765 3920 4243 2942 2255 3201 3120 M10121 GO_HEMOGLOBIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. 7/15 Gene Ontology BP GO:0020027 0.00363693083111297 0.00453201015804013 3540 2905.72727272727 2999 0.000364289684740424 2043 1.09095810023557 1.09095810023557 1 2.37345437211537 2043 2199 3538 2613 3532 2999 2481 3171 3347 3539 2501 3121 M15836 GO_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that modulates the frequency, rate or extent of viral genome replication. 54/138 Gene Ontology BP GO:0045069 1.53794032842609e-05 2.57599456886087e-05 2580 3049 2999 1.39813734519563e-06 1092 1.20378528983809 -1.17705578415326 -1 5.12792217160859 2580 4160 2801 4496 2684 1092 2999 3037 4074 3622 1994 3122 M14341 GO_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_APOPTOTIC_PROCESS.html Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 31/69 Gene Ontology BP GO:0051402 1.70553954678022e-06 3.53992852735832e-06 3000 2786.09090909091 3000 1.55049169908462e-07 1347 1.49564313515256 1.9620558258255 1 7.56787122053783 3000 3113 2383 2623 2161 4304 3296 1347 1853 3233 3334 3123 M13329 GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. 33/119 Gene Ontology BP GO:0002762 7.31577433656153e-08 2.57321744980891e-07 3435 2829.81818181818 3001 6.65070416348799e-09 1231 1.89358577349811 -2.05975189987696 -1 11.5826552118651 3433 3339 2144 4271 1231 2033 3937 2053 3293 3001 2393 3124 M10774 GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 20/30 Gene Ontology BP GO:0033158 0.000961033662846773 0.00126655671206289 2270 2989.27272727273 3005 8.74048846774184e-05 1348 1.21556374903889 1.51187397555745 1 3.26927623432181 2266 4044 2667 3925 3374 3005 2022 1348 3872 3599 2760 3125 M13846 GO_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T cell differentiation. 51/190 Gene Ontology BP GO:0045580 8.65044416574947e-06 1.51676783465162e-05 3010 3089.90909090909 3006 7.8640710724153e-07 2189 1.44311423258487 -1.1218715732867 -1 6.45556197125059 3006 3338 2196 4208 2555 2189 3506 4347 3609 2230 2805 3126 M15020 GO_ASYMMETRIC_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. 18/51 Gene Ontology BP GO:0008105 1.09391379784634e-06 2.40484931979194e-06 3895 3033.09090909091 3006 9.94467583433961e-08 1360 1.7422494884994 -1.51018168974029 -1 9.08723415214454 3891 2981 2230 2559 2042 4114 3225 3006 1360 3477 4479 3127 M15033 GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. 11/54 Gene Ontology BP GO:0045581 0.0247053333891723 0.0286123379710469 2365 3033.27272727273 3006 0.00227156440012123 2112 1.24446444931133 1.24810881962918 1 1.78296661236968 2362 3560 2443 3474 3723 3006 2112 2926 3733 2669 3358 3128 M13365 GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. 20/65 Gene Ontology BP GO:0046637 8.52496511583003e-05 0.000126458188603191 3135 3018.54545454545 3007 7.75026861345322e-06 2061 1.48240151941489 -1.2902050032883 -1 5.36392530819636 3131 2917 2141 3303 3007 2061 3729 4389 3611 2636 2279 3129 M14193 GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of cytoplasmic transport. 325/775 Gene Ontology BP GO:1903649 9.43284697778364e-09 6.64805736677504e-08 3995 2916.54545454545 3007 8.57531547111677e-10 456 1.41539565116844 -1.08772165820769 -1 9.42992864207472 3007 3542 2728 3994 456 2572 3143 2150 2869 3626 3995 3130 M15292 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that modulates the frequency, rate or extent of protein localization to nucleus. 158/363 Gene Ontology BP GO:1900180 1.95504453033625e-07 5.54506521340942e-07 3010 3023.90909090909 3009 1.77731336733872e-08 1565 1.40326545223221 -1.01127878862823 -1 8.149147608908 3009 4087 2736 3251 1565 3769 2662 1678 2961 3621 3924 3131 M13668 GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. 271/607 Gene Ontology BP GO:0033157 1.54486781854595e-08 8.82555423854249e-08 2935 2911.63636363636 3010 1.40442529944928e-09 657 1.41509191033677 -0.970015092295257 -1 9.26627363814776 2932 3624 2735 3377 657 3010 3172 2301 2590 3879 3751 3132 M16705 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. 24/61 Gene Ontology BP GO:0002763 8.72238624431588e-05 0.000129182743273934 3675 2971.27272727273 3011 7.92975643799365e-06 2161 1.56732856773047 -1.91284308231737 -1 5.65775687929107 3672 3053 2326 2536 3011 2647 4270 2544 3332 2161 3132 3133 M10212 GO_VIRAL_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_BUDDING.html A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. 16/25 Gene Ontology BP GO:0046755 0.000535162519173388 0.000725053859504534 3725 2708.45454545455 3014 4.86629768048261e-05 828 0.746348697992686 -0.607528786162867 -1 2.17515051354046 1731 3723 3014 4268 3991 828 1510 1223 4421 3723 1361 3134 M13432 GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION.html An organelle organization which involves another organism. 16/25 Gene Ontology BP GO:1902590 0.000282081093513683 0.000393777064697544 1735 2697.90909090909 3015 2.56470243702318e-05 829 0.746348697992686 -0.607528786162867 -1 2.35882683342168 1732 3724 3015 4269 3992 829 1511 1094 4422 3727 1362 3135 M15650 GO_MULTI_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves another organism. 16/25 Gene Ontology BP GO:1902592 0.000215532227090062 0.0003051894267701 1735 2695.18181818182 3016 1.95957586822956e-05 830 0.746348697992686 -0.607528786162867 -1 2.4355071216174 1733 3725 3016 4270 3993 830 1512 1050 4423 3732 1363 3136 M15708 GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. 9/27 Gene Ontology BP GO:0039531 0.00204344052313097 0.00260579355915877 1685 2756.09090909091 3017 0.000204532200068351 1174 0.884449549611664 -0.884449549611664 -1 2.12150841144104 1683 3017 4444 3704 3455 1174 1423 2009 4405 3092 1911 3137 M10684 GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 64/190 Gene Ontology BP GO:0032649 2.79643145162729e-06 5.45539127306954e-06 4630 3081.63636363636 3018 2.5422136419929e-07 1539 1.64293954579228 -1.38848252631524 -1 8.02672622497319 4628 2680 1539 2751 2305 3261 4303 3882 3018 1717 3814 3138 M11523 GO_POSITIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of STAT cascade. 35/133 Gene Ontology BP GO:1904894 3.5257066259541e-06 6.69797703122131e-06 3640 3089.72727272727 3020 3.20519297840253e-07 1602 1.56389624169994 -1.37425974805905 -1 7.51118087674522 3639 2772 1602 3483 2360 3998 3598 2731 3020 2392 4392 3139 M14717 GO_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEPHOSPHORYLATION.html The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. 137/325 Gene Ontology BP GO:0016311 4.09077436966984e-09 4.28055816013327e-08 3020 2899.18181818182 3020 3.718885797524e-10 168 1.28243813780854 -0.94104439976361 -1 8.77171719053373 3148 3029 2895 3135 168 3019 2657 3020 2773 3597 4450 3140 M15169 GO_BLASTOCYST_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_GROWTH.html An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. 7/17 Gene Ontology BP GO:0001832 0.000220202587793927 0.000311327836518637 1530 2486 3020 2.20224410968336e-05 488 0.775222454722332 -0.775222454722332 -1 2.52350532431818 1528 3020 4366 3343 3166 670 488 1097 3955 4556 1157 3141 M10436 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 762/2161 Gene Ontology BP GO:0010629 1.47807556340968e-08 8.69797825210536e-08 3025 2940 3021 1.47807557324086e-09 678 1.47962434451858 1.7467237964883 1 9.69752891058531 3021 3078 3583 4568 678 1937 2907 3267 2563 2203 4535 3142 M11240 GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION.html The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. 7/14 Gene Ontology BP GO:0036508 7.99920367652885e-06 1.41704529651585e-05 1270 2543.63636363636 3021 7.99923247094147e-07 207 0.740145278114521 -0.740145278114521 -1 3.33122450596817 1266 3021 3714 4321 4199 207 255 1806 4465 4354 372 3143 M15278 GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. 127/372 Gene Ontology BP GO:0071824 0.00848077928217256 0.0102275995343187 865 2806.09090909091 3021 0.000773968124370925 864 1.40311524436712 -1.39981687465452 -1 2.59217852849244 864 4067 3021 3376 3623 1710 2420 2294 3646 3470 2376 3144 M15878 GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. 35/133 Gene Ontology BP GO:0046427 3.5257066259541e-06 6.69797703122131e-06 3640 3087.09090909091 3021 3.20519297840253e-07 1603 1.56389624169994 -1.37425974805905 -1 7.51118087674522 3640 2773 1603 3484 2361 3999 3599 2692 3021 2393 4393 3145 M16654 GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 4/15 Gene Ontology BP GO:0060628 8.16368586588224e-05 0.000121448232858992 2380 2826.45454545455 3021 8.16398578734043e-06 900 0.680937159772716 0.822217482613248 1 2.47500133365039 2380 2646 4596 3272 3663 3021 1961 900 3793 3127 1732 3146 M12900 GO_PROTEIN_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMANNOSYLATION.html The removal of one or more mannose residues from a mannosylated protein. 7/14 Gene Ontology BP GO:0036507 7.99920367652885e-06 1.41704529651585e-05 1270 2574.36363636364 3022 7.99923247094147e-07 208 0.740145278114521 -0.740145278114521 -1 3.33122450596817 1267 3022 3976 4322 4200 208 256 1789 4466 4439 373 3147 M14502 GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. 14/30 Gene Ontology BP GO:0098927 0.000531783929841907 0.000720897163870358 2180 2639.90909090909 3022 4.8355683286655e-05 899 0.913011591196753 -0.913011591196753 -1 2.66298727362417 2178 3524 3022 3581 3959 899 1298 1972 3938 3615 1053 3148 M15175 GO_LIPOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving liposaccharide. 52/115 Gene Ontology BP GO:1903509 5.77994968366166e-08 2.18004113576288e-07 4325 2963 3022 5.25449985046853e-09 1136 1.17113278620345 -0.992582350801334 -1 7.24185131159604 4322 2258 2876 3022 1136 2171 3970 3116 2486 3532 3704 3149 M16460 GO_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERAD_PATHWAY.html Any process that modulates the frequency, rate or extent of ERAD pathway. 19/37 Gene Ontology BP GO:1904292 5.48087908137203e-08 2.103585322142e-07 3600 2810 3022 4.98261747083424e-09 1108 0.813926394433522 -0.744196264035512 -1 5.0447334741805 3600 2270 3030 3228 1108 1729 2858 3022 4039 3882 2144 3150 M12679 GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary amino compound. 6/25 Gene Ontology BP GO:1901160 0.0238087961045369 0.0276489579550994 3320 2816 3023 0.00240677966280631 649 2.29542851434649 -1.05336252206746 -1 3.32039595209306 3318 1765 3946 3023 4310 3545 2566 2115 649 2535 3204 3151 M10251 GO_REGULATION_OF_VESICLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_FUSION.html Any process that modulates the frequency, rate or extent of vesicle fusion. 31/71 Gene Ontology BP GO:0031338 0.000508604297759768 0.000691290911738467 2110 2744.90909090909 3025 4.62474469899709e-05 1487 1.10081430985865 -1.20043386062838 -1 3.22936305765827 2110 3293 2836 3512 3257 1487 3025 1961 3153 3835 1725 3152 M11596 GO_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BINDING.html Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. 8/21 Gene Ontology BP GO:1900120 0.0575689404417822 0.0647040887124655 1760 2995.09090909091 3025 0.0059117075513634 1757 1.4850608061708 1.4850608061708 1 1.63915535397984 1757 3191 3775 2049 3830 3020 2830 2744 3025 3642 3083 3153 M12191 GO_DNA_CONFORMATION_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE.html A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. 145/419 Gene Ontology BP GO:0071103 0.0571222357368346 0.0642175642920395 1110 3070.45454545455 3025 0.00533287754814862 1106 1.39791767577921 -1.32473731599675 -1 1.54722346282608 1106 4285 3025 3443 3820 2030 2782 2891 3689 3997 2707 3154 M16057 GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT.html The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. 6/21 Gene Ontology BP GO:0060525 0.00297797345858594 0.00374099858447362 3480 2819.09090909091 3026 0.000298197174828545 108 3.90545904962129 -2.72555383992707 -1 8.7985929396366 3480 3026 4502 1894 3506 3505 2336 1847 108 2553 4253 3155 M10478 GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of cholesterol homeostasis. 6/18 Gene Ontology BP GO:2000188 0.0673553465522451 0.075356837118572 2080 2909 3028 0.00694884585483001 1275 2.96294571455731 2.96294571455731 1 3.08834013356498 2077 3910 3594 3519 3862 3028 2288 2436 1275 3411 2599 3156 M10981 GO_SUCKLING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUCKLING_BEHAVIOR.html Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. 7/21 Gene Ontology BP GO:0001967 7.72657307033682e-05 0.000115352021754257 3175 3116.63636363636 3029 7.72684173317526e-06 1702 0.902586563611561 -0.988261566497849 -1 3.29936916268193 3175 1702 3666 3029 3006 2626 3491 3003 4193 3544 2848 3157 M13992 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 13/23 Gene Ontology BP GO:0009147 0.0433826332634508 0.0492603487997559 4050 3076.27272727273 3029 0.00402386368211464 1690 0.865695935956356 -0.865695935956356 -1 1.05069573745919 1690 4049 3029 4572 3927 1735 1877 2546 4047 3942 2425 3158 M15985 GO_RESPONSE_TO_FOLIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. 9/23 Gene Ontology BP GO:0051593 0.0192958066335278 0.0225384730061559 3085 3051.63636363636 3030 0.00194654309307843 2022 1.71713458548162 -2.11039943110988 -1 2.62534845477084 3083 2022 4491 3507 3704 2699 4418 2060 3030 2366 2188 3159 M14837 GO_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATPASE_ACTIVITY.html Any process that modulates the rate of ATP hydrolysis by an ATPase. 51/124 Gene Ontology BP GO:0043462 5.77648543629039e-08 2.18004113576288e-07 3695 2966.54545454545 3031 5.25135053451102e-09 1135 1.87558465102758 -1.6495957667821 -1 11.597920806835 3694 3031 1503 2870 1135 3237 3522 4405 2488 2597 4150 3160 M16527 GO_RESPONSE_TO_REDOX_STATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REDOX_STATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. 19/54 Gene Ontology BP GO:0051775 1.67970954738944e-07 4.94096576560838e-07 4050 3068.63636363636 3031 1.52700879603273e-08 1501 1.29881833237989 -1.16062562145744 -1 7.60299080042962 4046 1805 2365 2341 1501 4352 3639 3754 2625 3031 4296 3161 M14439 GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 7/29 Gene Ontology BP GO:0006144 9.53252189073683e-05 0.000140595613528244 3500 3084 3033 9.53293082580673e-06 2462 1.01058660683499 -1.38384557945125 -1 3.61353376499944 3497 2491 4236 3202 3033 2557 2735 2462 3829 2743 3139 3162 M14637 GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 11/25 Gene Ontology BP GO:0046386 9.27349865959476e-05 0.000136905736968199 695 2421.90909090909 3033 8.4308087105933e-06 691 0.748649790606763 -0.748649790606763 -1 2.68495827355934 1300 3643 3033 4184 3112 692 691 908 3912 3864 1302 3163 M12719 GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-beta production. 27/71 Gene Ontology BP GO:0032728 9.93468043434984e-07 2.20520429002255e-06 2885 3230.45454545455 3034 9.03153174601793e-08 2018 1.14515869590919 -1.21476185049205 -1 6.01293519337155 4562 3034 2883 3653 2018 2823 4625 2278 3470 3305 2884 3164 M15283 GO_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING.html Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. 52/107 Gene Ontology BP GO:0006342 0.0242601034650683 0.0281317833137642 2210 3073.09090909091 3035 0.00223016652402337 2206 1.53368291480569 -1.37550595005778 -1 2.20780768325237 2206 3918 2623 3366 3719 2378 2929 2966 3412 3252 3035 3165 M16695 GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERAD pathway. 10/17 Gene Ontology BP GO:1904294 0.00020189616718934 0.000286492635776316 4030 3068 3035 1.83558816163937e-05 1624 0.808591051500482 -0.709085734029494 -1 2.65922621683071 4027 1624 2955 2914 3141 2884 3035 3533 3019 3222 3394 3166 M16936 GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 24/58 Gene Ontology BP GO:0002067 1.38499855904658e-07 4.2278424126583e-07 4405 2418.54545454545 3035 1.25908967839859e-08 169 2.57603808392863 -2.36169058637065 -1 15.2414182473217 4402 3035 1125 781 1444 3340 4371 3120 169 1753 3064 3167 M14746 GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. 15/50 Gene Ontology BP GO:0046426 0.000170610694885304 0.000244489338380391 2840 2736.09090909091 3036 1.5511266112295e-05 812 1.36995375138379 1.6115092184428 1 4.59294787750937 2839 2364 2515 3036 3116 3644 3066 2017 812 3179 3509 3168 M15099 GO_NEGATIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STAT_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade. 15/50 Gene Ontology BP GO:1904893 0.000170610694885304 0.000244489338380391 2840 2737 3037 1.5511266112295e-05 813 1.36995375138379 1.6115092184428 1 4.59294787750937 2840 2365 2516 3037 3117 3645 3067 2016 813 3181 3510 3169 M11312 GO_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 22/50 Gene Ontology BP GO:0010762 3.95475156166404e-06 7.45510008152909e-06 3980 3201.36363636364 3038 3.5952351552728e-07 2381 1.15939813787155 -0.82137137638232 -1 5.51837658278805 3977 2724 2561 2797 2381 4173 3458 3080 3038 2394 4632 3170 M12178 GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 13/29 Gene Ontology BP GO:0034243 0.00428895048032477 0.00530463427814276 2605 3080 3038 0.000390666798198207 1281 0.760177540957599 -0.956307608839714 -1 1.60557756929934 2605 3937 3038 4341 4608 1281 1416 2262 4429 4399 1564 3171 M14544 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. 96/288 Gene Ontology BP GO:0002703 2.69199991381779e-07 7.27529429560885e-07 4550 2930 3040 2.44727294838249e-08 1654 1.47629471722201 -1.23523585726866 -1 8.41162018681041 4550 1980 1997 2622 1654 3356 3571 4069 3040 1889 3502 3172 M16504 GO_AUTOPHAGOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. 29/52 Gene Ontology BP GO:1905037 0.00156122407565846 0.00201802989512312 2745 3073.54545454545 3041 0.000142030281463162 1326 1.31961219792375 -1.36396384604213 -1 3.30130670504601 2742 3817 2974 4550 3403 1326 3041 2883 3457 3468 2148 3173 M15946 GO_RESPONSE_TO_ETHER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. 8/17 Gene Ontology BP GO:0045472 0.0296313080041141 0.0341215682200154 2495 2932.81818181818 3042 0.0030033992316424 896 2.28979291512943 2.28979291512943 1 3.11807713582808 2491 3042 4483 1766 3746 3252 2703 3968 896 3661 2253 3174 M16243 GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that activates or increases the rate of ATP hydrolysis by an ATPase. 34/76 Gene Ontology BP GO:0032781 0.0839184282471183 0.0891201423493528 2770 3174.27272727273 3042 0.00793650793650794 1985 1.70433515565462 1.81114316024431 1 1.66120553756019 2769 3111 1985 2862 4187 4620 2564 3862 2815 3100 3042 3175 M11905 GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 45/125 Gene Ontology BP GO:1903557 1.23405365774169e-05 2.10573727780032e-05 4340 3173.09090909091 3044 1.12187325456017e-06 1627 1.59011730869524 -1.13155708631807 -1 6.90284514945882 4339 2848 1627 2878 2629 4226 3923 3044 3169 2119 4102 3176 M11996 GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 70/157 Gene Ontology BP GO:0002224 2.76481884614994e-06 5.39825647715483e-06 4280 3189.72727272727 3048 2.51347483709363e-07 2169 1.63792991739012 -1.51530181675068 -1 8.00920320995061 4278 3140 2169 3048 2303 2846 4173 4582 2798 2622 3128 3177 M14315 GO_NON_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_RECOMBINATIONAL_REPAIR.html A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. 41/88 Gene Ontology BP GO:0000726 0.000113236123298368 0.000165487982522607 395 2313.54545454545 3048 1.02947229173587e-05 391 1.18207909777641 -1.18207909777641 -1 4.1490546969859 391 3688 3095 4251 3048 502 924 1064 3506 3768 1212 3178 M10772 GO_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ASSEMBLY.html Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. 145/403 Gene Ontology BP GO:0030031 1.09440441501177e-07 3.50677687984794e-07 4290 3219.45454545455 3049 9.94913154048767e-09 1367 1.29937464568005 -1.142776377433 -1 7.78584845736529 4286 2674 2947 4241 1367 2224 4230 4037 2678 3681 3049 3179 M11540 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. 8/23 Gene Ontology BP GO:2000696 5.89578259657399e-07 1.40380095363554e-06 3725 2856.45454545455 3050 5.89578416078592e-08 1337 1.56482109217913 1.64660402291281 1 8.50138483603729 3721 1337 3765 2092 1900 4103 3120 3050 2396 1519 4418 3180 M11832 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS.html The somatic process that results in the generation of sequence diversity of immunoglobulins. 13/29 Gene Ontology BP GO:0016445 0.000448390264468566 0.000613941609533339 2350 2865.81818181818 3050 4.07710616961727e-05 1190 0.953488762223971 -0.953488762223971 -1 2.84277865108114 2346 3641 3050 3517 4448 1675 2639 1190 3706 3506 1806 3181 M14172 GO_ZINC_II_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_II_ION_TRANSPORT.html The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 10/27 Gene Ontology BP GO:0006829 0.000136077527367454 0.000196641132762866 3050 2948 3050 1.23714495415494e-05 1972 1.50808803269696 1.69988554785486 1 5.18847098022768 3050 3188 1972 3255 3081 3528 2168 2991 2847 2483 3865 3182 M10830 GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mitochondrial DNA. 11/18 Gene Ontology BP GO:0032042 0.000379360583421762 0.000523283181469769 2645 3136.63636363636 3051 3.44932740798467e-05 1902 0.867911078901155 -0.867911078901155 -1 2.64353711288132 2645 3939 3051 4483 3226 2172 1902 2490 4078 4332 2185 3183 M11443 GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. 17/34 Gene Ontology BP GO:1901889 0.00418425556668236 0.00517790474309867 2800 2972.27272727273 3051 0.000381112272824719 2080 1.44880901552534 -1.62324998077801 -1 3.07416526136575 2796 3089 2080 2915 3537 3491 2109 3951 3051 2247 3429 3184 M15110 GO_CATECHOLAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_TRANSPORT.html The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 2/17 Gene Ontology BP GO:0051937 0.00307782877729258 0.00386121562090501 2205 3084 3051 0.00034244968777809 1286 0.678657906030477 -0.678657906030477 -1 1.52029189725448 2201 2581 4355 NA 3521 1468 1286 4447 4523 4550 1908 3185 M13400 GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT.html Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. 10/37 Gene Ontology BP GO:0060632 0.013972533531346 0.0165538334233324 2030 2980.81818181818 3052 0.00127837021578029 1379 0.745410382964383 -0.745410382964383 -1 1.23240416663889 2029 4177 3052 3314 4171 1379 2063 2557 4350 3809 1888 3186 M15567 GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of leukocyte degranulation. 24/56 Gene Ontology BP GO:0043300 6.82118794570641e-08 2.43497648363109e-07 4590 2891.27272727273 3052 6.20108014290915e-09 951 1.22479305818559 -1.24353384191716 -1 7.51905995763664 4587 951 2478 2510 1200 3222 4207 3662 2638 3052 3297 3187 M15707 GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. 27/60 Gene Ontology BP GO:0045668 1.08075711564651e-06 2.3804341973182e-06 3055 3021.81818181818 3052 9.82506951429368e-08 2040 1.63058204868642 1.04511381072496 1 8.51150632783594 3052 3366 2151 3231 2040 3838 2671 3307 2244 2886 4454 3188 M16439 GO_DOPAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_TRANSPORT.html The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 2/13 Gene Ontology BP GO:0015872 0.00307782877729258 0.00386121562090501 2205 3113 3052 0.00034244968777809 1287 0.678657906030477 -0.678657906030477 -1 1.52029189725448 2202 2582 4566 NA 3522 1469 1287 4446 4524 4623 1909 3189 M12476 GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. 7/12 Gene Ontology BP GO:0006677 0.000984127945811956 0.00129552198820667 2650 3163.81818181818 3055 9.84564046165746e-05 2152 0.884048396789015 -0.912644372707394 -1 2.36960219078466 2647 3023 3916 3464 3362 2431 3055 2152 4204 3557 2991 3190 M14883 GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. 14/44 Gene Ontology BP GO:0038083 0.00513468990371516 0.00630697492670621 3210 2773.63636363636 3055 0.000467883028931517 1093 1.06675924304538 -0.941390721946363 -1 2.17868032121297 3208 3055 2629 2803 3591 1093 1742 3282 3833 3616 1658 3191 M15231 GO_ISOPRENOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 10/33 Gene Ontology BP GO:0008299 6.17917843964076e-05 9.34220953932011e-05 2955 3032.27272727273 3055 5.6175927292092e-06 845 2.13959998672642 -2.13959998672642 -1 8.00310121441711 2955 3700 2300 4245 3579 2984 3847 845 3055 3818 2027 3192 M12961 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 20/47 Gene Ontology BP GO:1902235 1.87569772724528e-05 3.09483459402979e-05 4275 3143.54545454545 3056 1.70519429040463e-06 1851 0.946275817597225 -0.98365743486982 -1 3.96097422178232 4273 1851 2867 2143 2723 2223 4432 4041 3809 3161 3056 3193 M11308 GO_REGULATION_OF_HEAT_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEAT_GENERATION.html Any process that modulates the rate or extent of heat generation. 5/18 Gene Ontology BP GO:0031650 0.000897859394723939 0.0011863293027044 3060 2542.63636363636 3057 8.98222369316075e-05 365 3.04620931196268 -1.59486697271216 -1 8.27318485137088 3057 2452 3727 1492 3443 3481 3239 1355 365 2264 3094 3194 M13218 GO_GALACTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. 5/16 Gene Ontology BP GO:0006012 3.48757737121029e-05 5.50242097857615e-05 4065 3145.81818181818 3060 3.48763210680093e-06 1143 2.67305856910959 -1.3662589022327 -1 10.5689232519288 4061 3436 4034 2111 2857 4077 4504 3043 1143 2278 3060 3195 M12111 GO_INNER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 15/63 Gene Ontology BP GO:0036159 1.78914419963954e-05 2.96996657809309e-05 4295 3214.45454545455 3061 1.62650795452112e-06 2640 1.39109790982014 -1.48236659459435 -1 5.84603152156638 4293 2657 2640 3061 2711 3292 4460 2795 3319 3175 2956 3196 M16221 GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA.html The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. 14/60 Gene Ontology BP GO:0007339 0.000974996620357792 0.00128386537388577 2735 3020.90909090909 3062 8.8675362538383e-05 780 0.975927780441272 -0.975927780441272 -1 2.61943157948004 2733 3870 3062 3437 4261 780 1372 2808 4499 4607 1801 3197 M10377 GO_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. 27/78 Gene Ontology BP GO:0031060 2.37803646611761e-07 6.556545909848e-07 2450 2707.18181818182 3064 2.16185156651428e-08 917 0.945575103256894 -1.06446773197092 -1 5.42734240010107 2450 3549 3064 3677 1616 917 2788 3089 3943 3675 1011 3198 M10562 GO_REGULATION_OF_PODOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PODOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of podosome assembly. 9/27 Gene Ontology BP GO:0071801 3.9317340922939e-06 7.41563144338983e-06 3740 2803.36363636364 3064 3.93174104865105e-07 1098 1.34028725704497 -1.28112531790736 -1 6.38222103242008 3738 1098 3603 1376 2404 4126 3064 4124 1941 1643 3720 3199 M13246 GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 72/165 Gene Ontology BP GO:0072522 6.39494829280181e-08 2.32583599152169e-07 3950 2774.09090909091 3064 5.81358952608166e-09 782 1.14771279071124 1.30796040603153 1 7.06707836357451 3946 782 2759 3075 1179 2092 3152 4165 3064 2764 3537 3200 M13638 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS.html The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 20/43 Gene Ontology BP GO:0002200 0.0110352185034265 0.0131984851909864 2860 3226 3067 0.00100826937353116 2425 1.22796757339113 -0.947056044914847 -1 2.14236154020734 2857 3692 2976 3153 3641 2425 3063 3983 3026 3603 3067 3201 M13738 GO_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NIK_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). 58/119 Gene Ontology BP GO:0038061 0.00922902283807791 0.0111011277298435 2470 3093.81818181818 3069 0.000842542509153183 1246 1.29163171218393 -0.94095504434141 -1 2.34354344136624 2468 3713 3256 3069 4040 1246 2536 4219 2959 4067 2459 3202 M15257 GO_REGULATION_OF_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ASSEMBLY.html Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 12/28 Gene Ontology BP GO:0090169 0.000754320490599986 0.0010055440820717 1745 2841.72727272727 3069 6.85981137192042e-05 741 0.49227174192176 -0.49227174192176 -1 1.36976953465257 1745 3965 3069 3679 4266 741 1488 1586 4600 4563 1557 3203 M15329 GO_NUCLEOSIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSPORT.html The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/20 Gene Ontology BP GO:0015858 6.72176172869938e-06 1.20591729931805e-05 3075 3126.27272727273 3071 6.11071115099696e-07 2431 1.558237344413 1.5440202586789 1 7.11461700026133 3071 3250 2431 3199 2501 3757 2811 4549 2646 2670 3504 3204 M10757 GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of an adaptive immune response. 77/220 Gene Ontology BP GO:0002819 6.91240213199908e-07 1.60675969505168e-06 1925 2892.54545454545 3072 6.28400391261588e-08 1363 1.54209333656586 -1.43144769361378 -1 8.29396047027976 4445 2345 1921 2943 1922 3570 3745 3072 3151 1363 3341 3205 M13875 GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. 48/104 Gene Ontology BP GO:0045639 3.20171722967389e-06 6.16317292594356e-06 3300 2965 3072 2.91065626293251e-07 1395 1.73841972173456 1.77322198624967 1 8.40771155118917 3296 2999 1395 2177 2336 4143 3341 4410 3072 1471 3975 3206 M10070 GO_APICAL_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, apical regions of the cell. 11/30 Gene Ontology BP GO:0045176 0.000131896914800192 0.000190956462556062 3710 3197.36363636364 3073 1.19913475544168e-05 1800 1.61109937199464 -0.902798137585511 -1 5.56192717508288 3707 2985 2109 2780 3073 4136 3033 4633 1800 3308 3607 3207 M12547 GO_ETHANOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. 6/17 Gene Ontology BP GO:0006067 0.00254046888476299 0.00320614216688082 1880 2892.90909090909 3073 0.000254337785825645 1753 1.62439141582599 -1.62439141582599 -1 3.76061828133922 1877 3073 3928 4171 3482 1753 1860 2210 3906 3429 2133 3208 M14005 GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. 44/145 Gene Ontology BP GO:0050715 5.16877730631119e-07 1.25058014763955e-06 4375 2790.81818181818 3073 4.6988895642609e-08 680 1.81599362562178 -1.75258544745403 -1 9.9505716395172 4371 2042 1067 2454 1847 3630 3580 4071 3073 680 3884 3209 M11094 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO.html The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. 5/18 Gene Ontology BP GO:0008595 0.00012015537964499 0.000174720146474064 4290 2769.36363636364 3074 1.20161876931294e-05 1185 1.57620191726994 -1.65424352846761 -1 5.49791617940481 4289 1708 3687 1820 3074 3676 4328 1185 1535 1494 3667 3210 M11767 GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 82/223 Gene Ontology BP GO:0043433 1.64149194742747e-07 4.86399411493216e-07 2650 3054.27272727273 3075 1.49226551809506e-08 1492 1.18548096482797 -0.906935371524794 -1 6.94704292785313 2648 1981 2674 4243 1492 4624 2210 3075 3209 3487 3954 3211 M14898 GO_TRIPARTITE_REGIONAL_SUBDIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIPARTITE_REGIONAL_SUBDIVISION.html Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. 5/18 Gene Ontology BP GO:0007351 0.00012015537964499 0.000174720146474064 4290 2826.81818181818 3075 1.20161876931294e-05 1170 1.57620191726994 -1.65424352846761 -1 5.49791617940481 4290 1709 4312 1821 3075 3677 4329 1170 1536 1508 3668 3212 M10108 GO_MULTICELLULAR_ORGANISM_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_AGING.html An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). 16/39 Gene Ontology BP GO:0010259 0.000132246976728148 0.000191403588824436 3210 3112.72727272727 3076 1.20231751874697e-05 2051 2.08092064254342 2.76231671503017 1 7.18190845744917 3209 3321 2061 2379 3076 4522 4643 2292 2051 2687 3999 3213 M12302 GO_LIPOPROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_TRANSPORT.html The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/19 Gene Ontology BP GO:0042953 2.1801529214088e-05 3.56173469883922e-05 1570 2492.45454545455 3076 2.18017431050456e-06 494 1.34051513822214 1.73963865664646 1 5.53526822182865 1569 3218 3887 4192 4441 1040 494 703 3775 3076 1022 3214 M10358 GO_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. 20/56 Gene Ontology BP GO:0097028 0.000132981829790599 0.000192407178472345 2720 2941.18181818182 3077 1.20899880662412e-05 1737 1.67419155705895 2.03671445440497 1 5.77462941366626 2717 3844 2229 3710 3077 3877 2335 1737 3129 3157 2541 3215 M12255 GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 11/18 Gene Ontology BP GO:0042559 0.000206257205178608 0.000292502200257873 2440 3126.63636363636 3077 1.87524131823264e-05 1947 0.623737649159696 -0.623737649159696 -1 2.04607586811952 2440 3039 3077 3402 3143 1947 2544 3667 4094 4407 2633 3216 M13058 GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. 24/62 Gene Ontology BP GO:0032007 0.0839184282471183 0.0891201423493528 2890 3348.54545454545 3077 0.00793650793650794 2751 0.952528430129774 1.182551285149 1 0.928423816341818 2886 2751 3023 3188 4332 4120 3005 3077 3576 4001 2875 3217 M13347 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. 19/78 Gene Ontology BP GO:0032732 4.45468227961812e-07 1.10438481493348e-06 3080 2950.63636363636 3077 4.04971198329746e-08 1749 2.0653146899462 1.85839215881933 1 11.4202126003055 3077 3477 1749 3660 1797 4056 2667 3385 3002 2059 3528 3218 M13362 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 18/39 Gene Ontology BP GO:0098901 0.0839184282471183 0.0891201423493528 2845 3106.36363636364 3077 0.00793650793650794 1930 1.78205666424692 1.34300121290048 1 1.73696024805736 2841 4045 2064 3422 3941 3403 2362 2866 3077 1930 4219 3219 M14007 GO_MICROTUBULE_BUNDLE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BUNDLE_FORMATION.html A process that results in a parallel arrangement of microtubules. 45/140 Gene Ontology BP GO:0001578 6.32418196983347e-08 2.30661248122049e-07 3875 2936.63636363636 3077 5.74925650148199e-09 1176 1.87017959218431 2.08982663937025 1 11.5219483845171 3873 3050 2049 3077 1176 3602 3507 2863 1372 3146 4588 3220 M11042 GO_POSITIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOR_SIGNALING.html Any process that activates or increases the frequency, rate or extent of TOR signaling. 18/31 Gene Ontology BP GO:0032008 0.000133080080203469 0.000192489349652556 3840 3100.09090909091 3078 1.20989210022877e-05 1763 1.23220465118377 -0.765466354535373 -1 4.2499139392332 3837 2784 2891 3886 3078 1763 2982 3228 3289 3473 2890 3221 M13840 GO_REGULATION_OF_EXOSOMAL_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOSOMAL_SECRETION.html Any process that modulates the frequency, rate or extent of exosomal secretion. 11/20 Gene Ontology BP GO:1903541 0.0101024232107151 0.0121140369233859 2685 3044.90909090909 3078 0.000922646735349233 1270 0.491636098172691 -0.491636098172691 -1 0.874720820264558 2685 3702 3078 3977 3968 1270 1563 2322 4603 4492 1834 3222 M11871 GO_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROAUTOPHAGY.html The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. 182/417 Gene Ontology BP GO:0016236 1.39801287648482e-07 4.25637625279937e-07 3305 2899.18181818182 3079 1.27092087756638e-08 610 1.43596389126871 -1.12509116419317 -1 8.49214749765803 3305 4118 2613 4597 1445 610 3381 3079 2451 3988 2304 3223 M14064 GO_RETINA_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_LAYER_FORMATION.html The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. 10/38 Gene Ontology BP GO:0010842 0.000135309225503842 0.000195591760278436 4435 3221.54545454545 3080 1.2301595300479e-05 2016 1.1991357751175 -1.00945789232849 -1 4.12812904553542 4435 2016 2350 2899 3080 3828 4408 3475 2553 2482 3911 3224 M11222 GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. 15/31 Gene Ontology BP GO:1903392 0.000701728145510227 0.000937319844535093 2090 2797.27272727273 3081 6.38138248974507e-05 2037 1.42794359307008 1.27436805027267 1 4.01376677475659 2088 3122 2037 2911 3303 3114 2269 3133 3081 2602 3110 3225 M14212 GO_LIPOPROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_LOCALIZATION.html Any process in which a lipoprotein is transported to, or maintained in, a specific location. 9/19 Gene Ontology BP GO:0044872 2.0840231439555e-05 3.41670884794682e-05 1570 2522.09090909091 3082 2.08404268839956e-06 495 1.34051513822214 1.73963865664646 1 5.55773312540812 1570 3219 4206 4193 4442 1041 495 696 3776 3082 1023 3226 M10147 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT.html The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. 7/15 Gene Ontology BP GO:0010248 0.000329374877784427 0.000457459634326382 4460 3176.81818181818 3083 3.29423707485362e-05 1245 2.19375546547586 -3.29506164215868 -1 6.80076766446181 4459 2897 3543 2372 3220 4407 2807 1245 3083 2713 4199 3227 M14235 GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 9/20 Gene Ontology BP GO:0010745 0.0244247142211154 0.0283155925414828 2380 3208.72727272727 3083 0.00246973969124336 1473 1.60968513053786 1.60968513053786 1 2.31299021325025 2379 4106 4211 3741 4558 2590 1473 2370 3837 3083 2948 3228 M12375 GO_SYNAPTIC_VESICLE_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_ENDOCYTOSIS.html Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. 12/27 Gene Ontology BP GO:0048488 0.0058417466195925 0.00713874917685004 2925 2940 3084 0.000532483304574166 1049 2.25887766482022 3.08115078472998 1 4.50057514248418 2923 3938 2425 3084 3639 3813 3804 1721 1049 3397 2547 3229 M10194 GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-beta production. 36/97 Gene Ontology BP GO:0032648 5.39784209020618e-05 8.23060125610092e-05 3705 2888.54545454545 3085 4.90724957663419e-06 1305 1.14527823783427 -1.19755531747458 -1 4.34236481980981 3705 3085 3080 3892 2938 1435 3960 1656 3491 3227 1305 3230 M13063 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. 7/30 Gene Ontology BP GO:0002532 0.000127412005456673 0.000184924645619047 3295 2940.54545454545 3085 1.27419311264827e-05 1965 2.84228081189988 -3.15651108556967 -1 9.84905838378992 3292 3563 4003 2923 3085 2750 3161 2334 2161 1965 3109 3231 M15218 GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. 9/17 Gene Ontology BP GO:0034314 1.39465495407191e-05 2.35639845405963e-05 3690 2888.18181818182 3087 1.3946637069302e-06 777 1.25350997986407 -1.22341003132291 -1 5.38476717963483 3689 1968 4371 2314 2683 3508 4108 777 3157 3087 2108 3232 M12441 GO_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGY.html The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. 267/578 Gene Ontology BP GO:0006914 2.89572300633177e-08 1.34314105078905e-07 2945 2833.36363636364 3088 2.63247549495125e-09 515 1.32278364984792 -1.00732058258507 -1 8.43788135445952 2945 3810 3088 4599 887 515 3180 3091 2879 4143 2030 3233 M14715 GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. 10/44 Gene Ontology BP GO:0002710 0.0183739034468868 0.0215103463701198 2925 3030.54545454545 3088 0.00168447061219231 1879 1.98469151196367 -2.14536522761978 -1 3.07177623326433 2925 3728 2068 3633 4031 3088 4000 2007 2648 1879 3329 3234 M14825 GO_BODY_FLUID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_FLUID_SECRETION.html The controlled release of a fluid by a cell or tissue in an animal. 42/126 Gene Ontology BP GO:0007589 3.26086270205334e-07 8.51528994692558e-07 4310 2731.36363636364 3088 2.96442107761989e-08 899 1.93718774730022 -2.16839163580415 -1 10.9147871005625 4309 1946 899 3148 1710 3286 4172 2263 3088 1609 3615 3235 M13094 GO_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. 810/1884 Gene Ontology BP GO:0065003 3.110857194329e-08 1.40230193721063e-07 3205 2768.09090909091 3089 3.11085723787744e-09 953 1.48883250738137 -1.21132398634201 -1 9.47121618550502 3204 2874 4010 3089 953 1047 3374 3435 2362 3499 2602 3236 M13520 GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of lymphocyte differentiation. 68/229 Gene Ontology BP GO:0045619 2.17108658334492e-06 4.35248489053128e-06 3460 2873.63636363636 3089 1.9737170235464e-07 1705 1.63818909826303 -1.30632077381875 -1 8.15267731449822 3458 2679 1705 3350 2236 2154 3626 4297 3089 1715 3301 3237 M14442 GO_MITOCHONDRIAL_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FUSION.html Merging of two or more mitochondria within a cell to form a single compartment. 11/23 Gene Ontology BP GO:0008053 0.000267835259217639 0.000375017825255579 1610 2548.09090909091 3089 2.43516247204112e-05 875 1.00301225735576 -1.00301225735576 -1 3.18974623123584 1606 3899 3089 3352 3184 875 1312 1707 3767 3862 1376 3238 M13293 GO_ELECTRON_TRANSPORT_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_TRANSPORT_CHAIN.html A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 52/110 Gene Ontology BP GO:0022900 0.00221251507722652 0.00280675068403353 3090 2623.90909090909 3090 0.000201340301498897 925 1.02867993146438 -0.758156429502189 -1 2.43666235196144 1069 3388 3357 3175 3679 925 1131 3090 3087 4129 1833 3239 M11808 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. 13/26 Gene Ontology BP GO:1902116 0.000329791228634454 0.000457900919422778 1985 3019.09090909091 3091 2.99855160364208e-05 1983 0.995042128646424 -0.432045355658021 -1 3.08430074274686 1983 3091 2940 3097 3212 3016 2243 3988 3750 3505 2385 3240 M11907 GO_HISTONE_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEUBIQUITINATION.html The modification of histones by removal of ubiquitin groups. 10/27 Gene Ontology BP GO:0016578 1.60572276916252e-06 3.36889779359312e-06 2085 2618.18181818182 3091 1.45974903739908e-07 185 0.899215664229914 -0.899215664229914 -1 4.56793296675594 2085 4309 3091 4382 4625 548 1192 665 3918 3800 185 3241 M12160 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). 326/904 Gene Ontology BP GO:0006366 1.24324366819271e-07 3.884508984804e-07 4600 3124.81818181818 3092 1.13022158040886e-08 1248 1.47130051775695 1.72838266686712 1 8.75535028480176 4599 2117 3092 4607 1405 1248 4599 4587 2530 3137 2452 3242 M13137 GO_AMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 290/656 Gene Ontology BP GO:0043604 0.000159112763844651 0.000228789273004247 855 2504.72727272727 3093 1.44658429708087e-05 587 1.01884650460478 -0.892817739426488 -1 3.44307582747042 854 3973 3508 3498 3102 587 1560 1718 3093 4282 1377 3243 M13264 GO_NEUTRAL_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. 9/30 Gene Ontology BP GO:0046461 0.00604955042854859 0.00737606686968253 3535 3037.54545454545 3093 0.000606608248156971 2241 2.69632717638006 3.00464602543328 1 5.33659927736404 2241 3532 4040 3510 3600 3093 2424 2386 3534 2350 2703 3244 M13761 GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell. 14/55 Gene Ontology BP GO:0042491 0.00611626291710038 0.00745544991443872 2530 2946.72727272727 3093 0.000557575757903939 1566 1.94320704719645 2.30161078796459 1 3.83763000782181 2530 3581 2150 1566 3588 3940 3576 3093 2357 3614 2419 3245 M13981 GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphatidylinositol. 13/23 Gene Ontology BP GO:0046856 1.34520306485204e-05 2.28031319098504e-05 3045 3259.54545454545 3094 1.22291935476953e-06 2094 1.02250745169149 -1.03069475295945 -1 4.4059671474751 3044 3959 3073 4328 2645 2094 3100 3094 3764 3941 2813 3246 M14211 GO_ACYLGLYCEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 9/30 Gene Ontology BP GO:0046464 0.00604955042854859 0.00737606686968253 3535 3053.18181818182 3094 0.000606608248156971 2242 2.69632717638006 3.00464602543328 1 5.33659927736404 2242 3533 4205 3511 3601 3094 2425 2380 3535 2355 2704 3247 M15580 GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. 23/53 Gene Ontology BP GO:0000096 9.84037281535395e-08 3.23117758003454e-07 4620 3090 3096 8.94579386863969e-09 1330 1.4234639894952 -1.54960451690391 -1 8.5763615956493 4616 2592 2115 3773 1330 4014 4077 3096 2760 2053 3564 3248 M12417 GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 16/29 Gene Ontology BP GO:0045978 0.00275245886600382 0.00346520241726024 4105 3190.63636363636 3097 0.000250537141799377 2335 1.18230270640518 -1.00190187075414 -1 2.70010597410842 4104 2952 2573 4248 3479 2335 3183 3097 3381 2692 3053 3249 M15944 GO_ARACHIDONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. 16/110 Gene Ontology BP GO:0019369 3.27363684402627e-08 1.45019201656077e-07 3340 2873.27272727273 3097 2.97603353885322e-09 938 1.93925027046414 -2.06913261872089 -1 12.3102983244243 3337 2925 1337 3502 938 4159 3097 3633 2354 1688 4636 3250 M12742 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. 38/101 Gene Ontology BP GO:0032088 1.60225069624088e-05 2.67389214159307e-05 4355 3287.18181818182 3098 1.45660215043993e-06 1729 1.07851530582282 -0.739131490483231 -1 4.57807572774449 4355 1729 2870 3098 2697 2547 4467 4361 2419 3872 3744 3251 M11424 GO_RESPONSE_TO_COPPER_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COPPER_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. 20/42 Gene Ontology BP GO:0046688 8.87142152864279e-06 1.54907898298189e-05 2975 3221.90909090909 3099 8.06496118412331e-07 2003 1.50108129369457 -1.19221622127066 -1 6.70211346944618 2975 3212 2003 2979 2566 4601 3532 4018 3823 2633 3099 3252 M12013 GO_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. 21/47 Gene Ontology BP GO:0046513 2.85876326997652e-06 5.56763333158598e-06 3100 3060.81818181818 3099 2.59887907706225e-07 1743 1.14814015399166 -0.797362214810628 -1 5.59991359246602 3096 1743 2474 2547 2310 4486 3156 3707 3099 3247 3804 3253 M15441 GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 34/82 Gene Ontology BP GO:0051785 2.02458422011955e-06 4.09057638555921e-06 4295 3023.45454545455 3099 1.84053280297915e-07 1561 2.04247508430934 -1.98110066842475 -1 10.2157641359313 4291 4497 1561 2539 2219 3149 3601 2258 2623 3099 3421 3254 M11824 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of extracellular matrix assembly. 7/16 Gene Ontology BP GO:1901201 6.8703746786412e-07 1.60055943968545e-06 4485 2980.54545454545 3100 6.87037680273429e-08 1083 1.2531827682393 -0.944650574186242 -1 6.74204354917564 4484 1633 3813 1083 1951 3100 3348 4591 2595 1962 4226 3255 M11969 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. 268/647 Gene Ontology BP GO:0055086 9.82692505599224e-08 3.22904550849059e-07 1720 2634.36363636364 3100 8.93356863176347e-09 965 1.26390619115249 -1.00442039616022 -1 7.61536315989505 1718 3107 3136 4441 1329 965 2008 3154 3100 3956 2064 3256 M12214 GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. 10/23 Gene Ontology BP GO:0034104 0.000174706553946851 0.000250050101718629 3985 3159.90909090909 3100 1.58836753907802e-05 2137 2.35406265888118 -3.01173492793791 -1 7.87095805858551 3981 2892 2156 3100 3120 4214 3860 2554 2137 2474 4271 3257 M12780 GO_REGULATION_OF_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ORGANIZATION.html Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. 15/33 Gene Ontology BP GO:0090224 0.000515804179905294 0.000700666707811668 1755 2885.54545454545 3100 4.69022866572611e-05 683 0.49227174192176 -0.49227174192176 -1 1.44146113793104 1751 3987 3100 4503 4605 683 1326 1505 4577 4430 1274 3258 M14087 GO_RESPONSE_TO_VITAMIN_A http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_A.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. 7/32 Gene Ontology BP GO:0033189 0.00112568069056177 0.00147309341777856 3105 3283.27272727273 3101 0.000112625131807958 2283 3.24879727266743 -4.59624237618042 -1 8.53983885962817 3101 3534 4182 4318 3378 2711 4086 3012 2283 2739 2772 3259 M16557 GO_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PROCESS.html The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 20/73 Gene Ontology BP GO:0050886 1.25095119260161e-06 2.71029696091894e-06 4595 3142 3101 1.13722900355524e-07 1554 2.18221526607675 -1.84549034424455 -1 11.2768194892879 4594 2556 1554 3101 2075 3855 4117 4155 2495 2645 3415 3260 M10329 GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. 44/108 Gene Ontology BP GO:0009132 9.12091577392586e-06 1.58950294897295e-05 2250 3120.45454545455 3102 8.29177598934889e-07 1730 1.25687236351217 -0.977080331509188 -1 5.59870264858454 2249 4219 2958 4342 2573 1730 3144 3102 3578 3989 2441 3261 M16310 GO_ALKALOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). 7/31 Gene Ontology BP GO:0009820 4.23290172486155e-07 1.05833940272117e-06 3105 3166.27272727273 3102 4.23290253114732e-08 1263 1.22598754447217 1.46344352482619 1 6.80017916765889 3102 1263 4545 2630 1819 4294 3200 3943 2970 2758 4305 3262 M13838 GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. 34/140 Gene Ontology BP GO:0050829 2.99581346112623e-06 5.81260422064733e-06 3105 3049.90909090909 3103 2.72347049148475e-07 1826 1.93966294782605 1.76450903812503 1 9.4267998831141 3103 3112 1826 3431 2321 4096 2518 3463 2988 2682 4009 3263 M12133 GO_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of vacuolar transport. 21/40 Gene Ontology BP GO:1903335 0.0839184282471183 0.0891201423493528 2550 3292.18181818182 3104 0.00793650793650794 2504 0.893271758124996 -0.74641388590233 -1 0.870666676599526 2549 2554 2708 3358 4627 4210 2504 2914 4018 3668 3104 3264 M10844 GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 141/312 Gene Ontology BP GO:0034976 7.70283269440045e-09 5.93105343285262e-08 3190 2460.72727272727 3105 7.00257520124573e-10 379 1.21937012936397 -1.07315572509667 -1 8.18002847690733 3188 1657 3224 3800 379 431 3105 3294 2965 3960 1065 3265 M10962 GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. 10/28 Gene Ontology BP GO:0032780 6.71490048640089e-05 0.000101028136611663 3105 3114 3105 6.1046413174528e-06 1930 0.988369862128772 -0.988369862128772 -1 3.66577676651095 3105 3529 2909 3814 2964 2297 3648 1930 4197 3793 2068 3266 M16267 GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 130/307 Gene Ontology BP GO:0040029 0.000703080299487913 0.000938855861524987 2530 3012.72727272727 3105 6.39368265314461e-05 1658 1.58597949966715 -1.26578551347902 -1 4.4569386182913 2529 4119 2850 3491 3304 1658 3218 3105 2728 3534 2604 3267 M10565 GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS.html The process in which the left cardiac ventricle is generated and organized. 4/18 Gene Ontology BP GO:0003214 0.0126680908268214 0.015059182532051 1900 2862.09090909091 3106 0.00127408918375441 1296 2.02919072210194 2.02919072210194 1 3.43231938923206 1900 3334 3605 3159 3952 2294 1296 3055 3228 3106 2554 3268 M13435 GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response. 10/29 Gene Ontology BP GO:0002739 0.0256305481508164 0.0296542823484277 3810 3076.09090909091 3106 0.00235764667024752 1757 1.67076671592753 -1.67076671592753 -1 2.36964575482559 2504 4017 2691 4355 3809 1757 3106 2520 3808 3204 2066 3269 M15577 GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. 151/364 Gene Ontology BP GO:0006091 0.000881190036041938 0.0011652991561785 3015 3199.36363636364 3108 8.01402897056551e-05 1847 1.27708621505351 -0.810715845861084 -1 3.47764053532246 3011 3108 3305 3669 3340 1847 3003 4244 2547 4038 3081 3270 M11101 GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 4/21 Gene Ontology BP GO:0042136 0.00511676141951589 0.00628828037872215 3100 3075.45454545455 3109 0.000512858130256821 2240 3.75738042681177 -3.75738042681177 -1 7.67832864431705 3100 3258 3690 2240 3583 3297 3790 2879 2512 3109 2372 3271 M12152 GO_INNER_CELL_MASS_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_CELL_MASS_CELL_PROLIFERATION.html The proliferation of cells in the inner cell mass. 6/11 Gene Ontology BP GO:0001833 0.000998118741888878 0.00131207964852493 1910 2705 3109 9.9856733394897e-05 962 0.626084966781134 -0.626084966781134 -1 1.67495189817494 1906 3329 3857 3109 3367 962 1320 1686 4292 4396 1531 3272 M16315 GO_CENTROMERE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROMERE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. 28/52 Gene Ontology BP GO:0034508 0.0290784330102674 0.0335348148203357 1955 3018.54545454545 3109 0.00267909475324772 1877 2.15022223639226 -1.74802329678563 -1 2.94305542994616 1954 4164 1877 3575 3734 2433 3109 2978 3195 2998 3187 3273 M15245 GO_LINOLEIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LINOLEIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 10/30 Gene Ontology BP GO:0043651 4.2066893757745e-07 1.05235230451083e-06 4645 3097.36363636364 3111 3.82426380013551e-08 975 1.07976370722794 -1.14297144050773 -1 5.99158957101054 4643 975 2090 3073 1783 3479 4127 4330 3111 2493 3967 3274 M13933 GO_NADH_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_METABOLIC_PROCESS.html The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 21/54 Gene Ontology BP GO:0006734 0.00164427097977526 0.00212006391532811 2165 3071.81818181818 3112 0.000149591017144607 874 1.39226559094739 -1.39226559094739 -1 3.45538091991622 2161 4381 3112 4464 4293 874 2543 2242 4212 3950 1558 3275 M15080 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes outside the context of DNA replication. 34/63 Gene Ontology BP GO:0006336 0.0839184282471183 0.0891201423493528 1580 3064.72727272727 3112 0.00793650793650794 1580 1.95140379501536 -1.57825921229869 -1 1.90202192914468 1580 4162 2071 3589 3960 2428 3084 2917 3422 3387 3112 3276 M12503 GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 4/107 Gene Ontology BP GO:0048387 0.00230502787207044 0.0029177329362113 1945 2770.09090909091 3113 0.000230742228737041 1134 1.48187060274341 -1.48187060274341 -1 3.4869808440125 1941 3306 3919 3864 4056 1134 1636 2412 3663 3113 1427 3277 M12669 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. 10/21 Gene Ontology BP GO:0046500 0.000198358084182934 0.000282075523694139 3115 3097.72727272727 3113 1.80341791776564e-05 2328 1.56989733466341 -2.01691817947862 -1 5.17278021158487 3113 3454 2479 4085 3135 2938 3782 2328 2618 3200 2943 3278 M16465 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures, occurring outside the context of DNA replication. 34/63 Gene Ontology BP GO:0034724 0.0839184282471183 0.0891201423493528 1585 3063.81818181818 3113 0.00793650793650794 1581 1.95140379501536 -1.57825921229869 -1 1.90202192914468 1581 4163 2072 3590 3961 2429 3085 2897 3423 3388 3113 3279 M10443 GO_LYSOSOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_TRANSPORT.html The directed movement of substances into, out of or within a lysosome. 50/101 Gene Ontology BP GO:0007041 0.000101835847446408 0.000149602212607794 1290 2465.45454545455 3115 9.25823287578641e-06 452 1.03595478716726 -0.989317411214838 -1 3.67831058474863 1288 3443 3259 3306 3115 452 1332 1758 3879 4056 1232 3280 M13064 GO_PREPULSE_INHIBITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREPULSE_INHIBITION.html The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. 4/22 Gene Ontology BP GO:0060134 0.00156403179329282 0.00202109646987436 2640 3138.36363636364 3115 0.000156513367287277 1328 2.22053514483406 -2.22053514483406 -1 5.55380894621545 2638 3999 4004 1827 4176 2365 2271 4367 4432 3115 1328 3281 M12505 GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of T cell tolerance induction. 18/53 Gene Ontology BP GO:0002664 0.0346598444693321 0.0397053189911446 2925 2974 3117 0.00320165890379123 2085 1.80115175959504 -1.77874325355641 -1 2.34263403413748 2924 3298 2085 3117 3755 2419 3334 3150 3127 2413 3092 3282 M16110 GO_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_PROLIFERATION.html The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. 16/52 Gene Ontology BP GO:0007405 0.000114217853557178 0.00016671282428984 2900 3236.72727272727 3117 1.03839803509157e-05 2702 1.37270182160462 1.34422509010577 1 4.81405280772811 2896 3274 2731 3524 3050 3880 3376 4247 3117 2702 2807 3283 M16711 GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION.html Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. 8/23 Gene Ontology BP GO:0048070 0.0765897756730953 0.0843068583333764 4275 3308.18181818182 3117 0.00793650793650794 2154 1.36183247845965 -1.49286368558638 -1 1.35785213441806 4274 3066 4609 2696 3917 3117 3882 2658 2494 2154 3523 3284 M13360 GO_MITOCHONDRIAL_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_PROCESSING.html The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. 7/12 Gene Ontology BP GO:0000963 0.0400273354547767 0.0455842331411646 2200 3069.09090909091 3118 0.00407671448155505 2196 1.08784629205609 -1.08784629205609 -1 1.35433284980011 2196 3222 4060 2820 3778 2263 3118 2543 3785 3561 2414 3285 M15498 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 20/37 Gene Ontology BP GO:1900101 4.33090506131139e-05 6.70950690679639e-05 4545 3503.54545454545 3118 3.93726392869468e-06 2885 1.03314721142893 -0.99068720899367 -1 4.00232093948614 4541 3118 2924 3010 2885 3102 4302 3070 4266 3606 3715 3286 M12200 GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 38/100 Gene Ontology BP GO:0009118 6.44593451396841e-05 9.71703699621926e-05 4215 3171.27272727273 3120 5.86011216879857e-06 2025 1.13446899314777 -0.952511425783061 -1 4.22545161147366 4215 2508 2838 3120 2958 2025 3794 3524 3465 3005 3432 3287 M12234 GO_GPI_ANCHOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GPI_ANCHOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. 16/33 Gene Ontology BP GO:0006505 0.000206886536318279 0.000293305095610922 2155 2870.09090909091 3120 1.88096358502098e-05 1489 0.757827521217807 -0.757827521217807 -1 2.48509976020168 2155 3120 3260 3799 3144 1489 2214 2201 4020 4401 1768 3288 M13591 GO_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 58/157 Gene Ontology BP GO:0006633 7.37924431908165e-07 1.70118328567508e-06 3355 3194.81818181818 3120 6.70840617657308e-08 1944 1.49667186810574 1.70100176146066 1 8.01521178587143 3351 3082 2162 4377 1944 3886 3638 3067 3120 2767 3749 3289 M13825 GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 20/39 Gene Ontology BP GO:0009262 0.000416603059710959 0.000572443920165132 1465 2958.18181818182 3120 3.78801791528755e-05 1418 0.802238512858201 -0.83456481492994 -1 2.41446767770485 1463 4263 3120 4534 3235 1418 1992 2627 4077 3915 1896 3290 M11173 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. 9/22 Gene Ontology BP GO:2000010 1.8150313565322e-07 5.2505860363732e-07 3145 2496.09090909091 3121 1.81503150477746e-08 219 2.53179621992721 -1.59279027135272 -1 14.7585318834027 3144 979 3701 1180 1571 3979 3584 4333 219 1646 3121 3291 M12254 GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 15/26 Gene Ontology BP GO:0050860 2.4732771536665e-05 4.00258829713265e-05 3405 3008 3121 2.24845905373053e-06 1124 1.98888488771614 -2.0473329101603 -1 8.11895879979608 3401 3121 1421 3257 2774 3995 2324 4277 3000 1124 4394 3292 M12852 GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 47/96 Gene Ontology BP GO:0070301 8.74001870246305e-07 1.97373087721478e-06 3325 3179.54545454545 3121 7.94547470422133e-08 1989 1.36876709917133 1.48935864201864 1 7.24823752393594 3323 2505 2298 2894 1989 4301 3552 3121 2966 3771 4255 3293 M14657 GO_CELLULAR_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 101/213 Gene Ontology BP GO:0071478 4.9847027593937e-06 9.19871816846779e-06 2815 3170 3121 4.53155823058122e-07 2435 1.40962845724066 1.7657428817709 1 6.58996372771973 2814 3572 2492 3132 2435 4049 3668 2691 3121 3009 3887 3294 M15607 GO_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of ATP metabolic process. 38/100 Gene Ontology BP GO:1903578 6.44593451396841e-05 9.71703699621926e-05 4220 3174.36363636364 3121 5.86011216879857e-06 2026 1.13446899314777 -0.952511425783061 -1 4.22545161147366 4216 2509 2839 3121 2959 2026 3795 3547 3466 3007 3433 3295 M14565 GO_HAIR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hair cell. 18/64 Gene Ontology BP GO:0035315 0.0301963320217213 0.0347377526206274 2820 3098.45454545455 3122 0.00278353985043829 1711 1.63192369749971 2.30161078796459 1 2.21046305571351 2816 3428 2450 1711 3740 4439 3560 3122 2511 3843 2463 3296 M11127 GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of endothelial cell differentiation. 13/40 Gene Ontology BP GO:0045601 0.0001666789453974 0.000239224217459081 4305 3165.90909090909 3124 1.51537795327378e-05 1599 1.87237093929102 -1.88007575317434 -1 6.29379966578276 4303 3124 1599 2370 3113 3939 3572 4414 3027 1778 3586 3297 M12274 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that stops, prevents or reduces the rate of gene expression. 63/125 Gene Ontology BP GO:0045814 0.0170000256632388 0.0200028178293 2295 3079 3124 0.00155752987503993 2294 1.61067757453672 -1.3748317433843 -1 2.54008231347566 2294 4071 2622 3180 3683 2401 3139 3124 3255 3014 3086 3298 M16106 GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT.html The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. 4/18 Gene Ontology BP GO:0021891 0.0284207804033102 0.0327926648639586 3020 3269.09090909091 3124 0.00287909442532899 2167 1.74666645914289 -1.74666645914289 -1 2.40645823131173 3020 3856 4508 3598 4380 2271 2834 2167 3450 3124 2752 3299 M16222 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 22/35 Gene Ontology BP GO:0090503 0.000699142724789619 0.000934404050431261 2335 3045.36363636364 3124 6.35786368871568e-05 1203 0.737503618194686 -0.737503618194686 -1 2.07395455347829 2335 3037 3124 4095 3301 1203 2512 3297 4209 4101 2285 3300 M15012 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 55/120 Gene Ontology BP GO:0071158 3.14444793147018e-08 1.410589268863e-07 2355 2941 3125 2.85858906946692e-09 923 1.47426931277422 1.6630105328905 1 9.37507028306098 2353 3917 2316 3125 923 4584 3133 2469 2503 3845 3183 3301 M16248 GO_NEGATIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_KILLING.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. 21/80 Gene Ontology BP GO:0031342 0.0839184282471183 0.0891201423493528 3125 3200.72727272727 3125 0.00793650793650794 2130 1.9559426035166 -1.49797442743323 -1 1.90644587986619 3125 3662 2130 3000 3933 2587 3966 4003 2772 2776 3254 3302 M16545 GO_RESPONSE_TO_HISTAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HISTAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. 4/19 Gene Ontology BP GO:0034776 0.000829462251795428 0.00110065539728099 2540 2952.63636363636 3126 8.29772017968279e-05 665 1.10855631282333 -1.10855631282333 -1 3.04422133678938 2538 3623 4577 3791 4355 1540 665 2274 4304 3126 1686 3303 M16819 GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 27/55 Gene Ontology BP GO:0010823 5.06106957562499e-07 1.22707812217373e-06 4015 3039.18181818182 3126 4.60097339992493e-08 1146 1.11096834453978 -0.853585454620057 -1 6.09594668866799 4013 3177 3012 3126 1841 1146 3006 4339 3652 3679 2440 3304 M13506 GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. 11/28 Gene Ontology BP GO:0051570 0.0232315332608956 0.0269997519224877 3415 3219.54545454545 3127 0.00213459477028022 2041 0.897478658757308 -0.966978756794417 -1 1.30682234752184 3415 3127 2907 3012 3861 2220 3077 4253 3644 3858 2041 3305 M15206 GO_STEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 22/70 Gene Ontology BP GO:0016126 3.53397201470132e-05 5.5677747079261e-05 3875 3118.54545454545 3127 3.21275343997257e-06 2388 1.53134291353672 1.34247045452598 1 6.04743996013102 3872 2388 2430 3334 2846 2900 3543 3127 2717 3338 3809 3306 M13321 GO_REGULATION_OF_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 10/23 Gene Ontology BP GO:0044030 0.000169806485001845 0.000243487186492762 3030 3120.09090909091 3128 1.54381448083711e-05 1007 2.60423267449612 -2.60423267449612 -1 8.73534065153616 3026 4310 2853 3128 4054 2344 3851 1007 3365 3808 2575 3307 M14704 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE.html The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. 30/50 Gene Ontology BP GO:0006120 0.000450338276263359 0.000616245392481808 885 2581.09090909091 3129 4.09482260529342e-05 662 0.693218920585465 -0.693218920585465 -1 2.06575048427874 883 3394 3380 3129 3788 662 853 2214 4438 4164 1487 3308 M15933 GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING.html The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. 10/23 Gene Ontology BP GO:0000729 0.0154132993204015 0.0182189278881426 2045 3014.09090909091 3130 0.00141112334441859 1323 0.53086987222574 -0.53086987222574 -1 0.857187549730674 2042 3701 3130 4036 3971 1417 1323 2340 4381 4598 2216 3309 M13390 GO_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINESIS.html Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. 35/100 Gene Ontology BP GO:0032465 0.000858858204738861 0.00113803614286602 1685 2883.63636363636 3131 7.81085161671985e-05 818 1.33080936141043 -1.33080936141043 -1 3.63663529276742 1681 4411 3131 4224 4484 818 2349 1323 3948 4124 1227 3310 M13830 GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. 16/29 Gene Ontology BP GO:1903579 0.00275245886600382 0.00346520241726024 4105 3194.90909090909 3131 0.000250537141799377 2336 1.18230270640518 -1.00190187075414 -1 2.70010597410842 4105 2953 2574 4249 3480 2336 3184 3131 3382 2696 3054 3311 M14416 GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. 11/18 Gene Ontology BP GO:2000001 0.00122434694032744 0.00159810907297589 2060 2924.18181818182 3132 0.000111366258806906 817 0.824553933122084 -0.824553933122084 -1 2.14035822206771 2057 4234 3132 3825 4550 817 1393 2497 4289 3861 1511 3312 M10690 GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an alpha-amino acid. 35/84 Gene Ontology BP GO:1901607 2.60725438592362e-07 7.10415617009588e-07 3135 2937.27272727273 3133 2.37023154083043e-08 1309 1.41960753373147 -1.20752067907798 -1 8.10225152476272 3133 2221 2217 1940 1638 4513 3814 4226 1309 3139 4160 3313 M15747 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 5/18 Gene Ontology BP GO:2000515 0.0498403700028629 0.0563038535093169 3030 3454.90909090909 3133 0.00509948096641552 2482 0.660651854809574 0.660651854809574 1 0.766239782097293 3028 3076 4451 2658 3808 3133 2844 2482 4329 4589 3606 3314 M11739 GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT.html The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. 8/21 Gene Ontology BP GO:0060712 0.000180210696826176 0.000257531014270217 4445 3052.45454545455 3134 1.8022531264722e-05 382 2.02609077562332 -2.69922897672991 -1 6.75028506265955 4442 2487 3798 1927 3134 4512 4025 2911 382 2127 3832 3315 M11997 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. 265/608 Gene Ontology BP GO:0032388 8.23001985277472e-09 6.16322293168275e-08 2805 2905.90909090909 3134 7.48183625778412e-10 405 1.47184732163567 -1.06387698049761 -1 9.85096400670373 2804 3598 2562 3926 405 3278 3134 2117 2736 3625 3780 3316 M16324 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. 22/51 Gene Ontology BP GO:0019883 0.048081589045264 0.0543963981328365 3165 3120.18181818182 3135 0.00446961329112124 2344 1.68519998284749 -1.06914567374715 -1 1.97794989317624 3161 3720 2344 2570 3789 2411 3652 3576 3135 2876 3088 3317 M13874 GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. 10/35 Gene Ontology BP GO:0034142 1.3964679667258e-05 2.35860340833317e-05 3775 2676.72727272727 3136 1.26952439181731e-06 366 3.13733272636205 -1.27583170891968 -1 13.4760186420825 3775 3014 1954 1378 3136 4506 3309 629 366 3207 4170 3318 M14295 GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 12/34 Gene Ontology BP GO:0055094 7.94859214183159e-05 0.000118552243220444 2940 3047.81818181818 3136 7.22625394428076e-06 1680 2.38838071065978 1.79639482046946 1 8.70428220127407 2936 3402 1680 3281 2992 3506 2130 3464 3136 2808 4191 3319 M15427 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 10/30 Gene Ontology BP GO:0071354 0.00851377415587772 0.0102647243328331 3140 3159.45454545455 3138 0.000776991018636139 1968 1.88022085541321 -1.16629598446259 -1 3.47085865864329 3138 4205 2101 4200 3624 4041 2410 1968 2921 2494 3652 3320 M13931 GO_REGULATION_OF_PROTEIN_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_STABILITY.html Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. 134/304 Gene Ontology BP GO:0031647 2.14205564131534e-08 1.07986583524725e-07 3060 2635.54545454545 3139 1.94732332924702e-09 504 1.22372512697164 -1.32580060628011 -1 7.91363046631311 3059 3139 3154 4259 782 504 3897 2193 3435 3773 796 3321 M13848 GO_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLESION_SYNTHESIS.html The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. 21/55 Gene Ontology BP GO:0019985 0.000828312436826914 0.00110007283872636 1380 2800.90909090909 3140 7.53294968751959e-05 959 0.9253612438005 -1.06151117103052 -1 2.5413443710255 1380 4195 3140 4399 4150 959 1722 1309 4172 3949 1435 3322 M13880 GO_RETINAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. 6/26 Gene Ontology BP GO:0042574 9.71498617686615e-05 0.000143195812124411 1470 2649 3140 9.7154109173038e-06 370 1.98661020509644 1.98661020509644 1 7.08880522336666 1466 3166 4151 3140 4434 1136 370 2884 3710 3440 1242 3323 M12635 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS.html Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. 35/80 Gene Ontology BP GO:0050690 4.02974184631328e-05 6.2891063503975e-05 4200 3257.63636363636 3141 3.66346878274672e-06 1842 1.04620042449806 -0.89096175405272 -1 4.08017872436897 4197 1842 2865 2048 2874 2942 4581 4466 3375 3141 3503 3324 M14516 GO_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPOLYMERIZATION.html The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. 21/40 Gene Ontology BP GO:0051261 5.27897841324395e-05 8.06525686664464e-05 4010 3173.54545454545 3141 4.79918644406183e-06 1894 1.62022576936551 -1.50509018225243 -1 6.15640124046882 4009 3843 1894 2362 2932 2615 4331 3141 3580 3250 2952 3325 M10612 GO_CELLULAR_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 56/108 Gene Ontology BP GO:0034644 0.000806941743971285 0.00107261108424239 4485 3316.18181818182 3142 7.33852614167308e-05 2332 1.42084406887202 -0.799077244518598 -1 3.91658277388354 4481 3142 2332 2764 3326 2979 4163 2746 3029 3485 4031 3326 M10683 GO_AMIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSPORT.html The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 47/124 Gene Ontology BP GO:0042886 3.57253139299466e-07 9.22539669503572e-07 4465 3026.63636363636 3143 3.24775633920934e-08 947 1.87445489928994 -1.42422352424892 -1 10.500802239593 4463 3143 947 3083 1725 3280 4554 3685 2763 1702 3948 3327 M12959 GO_REGULATION_OF_CHEMOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_SECRETION.html Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. 5/20 Gene Ontology BP GO:0090196 0.00710031717964975 0.00860976042442251 3145 3117 3143 0.000712310625286734 1805 2.01370869963196 -2.01370869963196 -1 3.86000351671986 3143 2873 3986 3781 3742 2644 3479 1805 4110 2277 2447 3328 M12060 GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. 36/125 Gene Ontology BP GO:1901616 9.50855765349922e-07 2.12772602874852e-06 3600 3022.09090909091 3145 8.64414705742588e-08 1022 1.92423783326625 -1.38472774647973 -1 10.131425589406 3596 3145 1022 3253 2005 4196 2726 3767 2720 2452 4361 3329 M12478 GO_NCRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_TRANSCRIPTION.html The transcription of non (protein) coding RNA from a DNA template. 46/106 Gene Ontology BP GO:0098781 0.000460052203230391 0.000628981855005508 1590 2768.72727272727 3145 4.1831675914028e-05 832 1.12948361745024 -1.06757969184229 -1 3.35647812922945 1589 4099 3327 4497 4006 832 1915 1199 3145 4137 1710 3330 M10887 GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. 117/261 Gene Ontology BP GO:0032104 1.8099978581154e-08 9.79548010514773e-08 3140 2693.54545454545 3147 1.64545261182429e-09 707 1.18155220951092 -1.01303853522378 -1 7.68734749725721 3139 2304 3168 3733 707 854 3147 3375 3426 3852 1924 3331 M12454 GO_SPHINGOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. 7/13 Gene Ontology BP GO:0046519 3.89180780528909e-05 6.09226690490804e-05 3505 3134.36363636364 3147 3.89187596472507e-06 1496 1.08617962426447 -1.06047086957244 -1 4.2500215311634 3505 1496 3910 3136 2883 2825 3450 3822 3579 2725 3147 3332 M15464 GO_POSITIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_KILLING.html Any process that activates or increases the frequency, rate or extent of cell killing. 31/84 Gene Ontology BP GO:0031343 0.000159842533587814 0.000229767456175919 3150 3072.36363636364 3147 1.4532195294541e-05 2240 1.39997881995006 -1.0853319669052 -1 4.72866132620975 3147 2777 2240 3351 3103 2342 3982 3630 3575 3234 2415 3333 M10727 GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. 8/15 Gene Ontology BP GO:0045779 0.000192385459250242 0.000274169946991673 3825 3012 3148 1.92402116754115e-05 1906 3.01173492793791 -3.01173492793791 -1 9.95812042895543 3822 3192 3626 2928 3148 2774 3632 1906 2046 2903 3155 3334 M11555 GO_REGULATION_OF_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of tolerance induction. 20/59 Gene Ontology BP GO:0002643 0.0603779319012649 0.0677628082711078 2905 3093.09090909091 3148 0.00564559790203037 2262 1.80115175959504 -1.77874325355641 -1 1.95450646479142 2905 3721 2262 3488 3826 2493 3255 3086 3206 2634 3148 3335 M13209 GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that modulates the frequency, rate or extent of a response to nutrient levels. 117/261 Gene Ontology BP GO:0032107 1.8099978581154e-08 9.79548010514773e-08 3140 2703.18181818182 3148 1.64545261182429e-09 708 1.18155220951092 -1.01303853522378 -1 7.68734749725721 3140 2305 3169 3734 708 855 3148 3471 3427 3853 1925 3336 M15776 GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION.html The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. 11/35 Gene Ontology BP GO:0021799 0.012548838115451 0.0149280695285778 2625 3041.09090909091 3148 0.00114736307047129 1915 1.44972484037541 1.44972484037541 1 2.45727969445826 2623 3964 2720 4042 3817 3148 2404 1915 3263 3329 2227 3337 M11510 GO_NEGATIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. 8/18 Gene Ontology BP GO:0046851 0.000192385459250242 0.000274169946991673 3825 3027 3149 1.92402116754115e-05 1921 3.01173492793791 -3.01173492793791 -1 9.95812042895543 3823 3193 3760 2929 3149 2775 3633 1921 2047 2911 3156 3338 M12782 GO_PHOSPHOLIPID_SCRAMBLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_SCRAMBLING.html The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). 8/21 Gene Ontology BP GO:0017121 0.00123706430765914 0.00161339594956781 4160 3041.36363636364 3149 0.000123775349532665 1420 2.03282054552284 1.43902903672741 1 5.26894751097891 4160 1969 3958 2356 3493 4593 3149 1420 1819 2131 4407 3339 M15397 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein. 23/68 Gene Ontology BP GO:0042516 1.01632878754083e-05 1.76075170169854e-05 3580 3100.54545454545 3149 9.23939529710199e-07 1723 1.32138888131198 -0.933980713398055 -1 5.83158392083882 3580 3149 2191 4201 2594 1723 3151 4598 3434 2993 2492 3340 M16861 GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION.html A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. 13/22 Gene Ontology BP GO:0042772 0.000310003982621502 0.000431718203752739 3355 2779.27272727273 3149 2.81861521983248e-05 714 2.77722481813066 -1.82689790507333 -1 8.67439867293917 3352 3727 1823 3149 3207 4066 3048 1687 714 2323 3476 3341 M16013 GO_CELLULAR_COMPONENT_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY.html A cellular process that results in the breakdown of a cellular component. 334/744 Gene Ontology BP GO:0022411 6.88275171933459e-08 2.45254153744209e-07 3285 2843.45454545455 3150 6.25704721333008e-09 1181 1.52707050406121 -1.13653618214798 -1 9.37032999329016 3282 3809 2113 3200 1205 1181 2938 4152 2548 3700 3150 3342 M13287 GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. 8/15 Gene Ontology BP GO:0032354 0.000195603382235689 0.000278584817092118 3510 3112.27272727273 3151 1.95620601676323e-05 1261 3.73205861465744 -3.57235249104043 -1 12.3157934025661 3508 2110 4043 2038 3151 4241 3127 4563 1261 2922 3271 3343 M16520 GO_ENDODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the endoderm. 6/16 Gene Ontology BP GO:0001711 0.00019627114468207 0.000279278861403263 2690 3089.81818181818 3152 1.96288481900218e-05 2199 1.30178092011579 1.49049140884192 1 4.29457108252081 2687 2201 4573 2406 3152 3421 2199 3315 3112 3459 3463 3344 M15119 GO_OSTEOBLAST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DEVELOPMENT.html The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. 15/31 Gene Ontology BP GO:0002076 1.22179957653377e-05 2.08943478226383e-05 2625 3282.27272727273 3155 1.11073305637703e-06 2014 2.14647732261869 1.95345181684923 1 9.32478046504943 3487 3155 2014 2492 2625 4497 4267 4332 2624 2608 4004 3345 M15163 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION.html The process in which immune receptor genes are diversified through somatic mutation. 6/14 Gene Ontology BP GO:0002566 0.0014250844086311 0.00184823098024419 2685 3160.36363636364 3156 0.000142599912382567 2302 0.930104113509802 -0.930104113509802 -1 2.35982085126466 2684 3565 4364 3156 3405 2302 2949 2419 4132 3452 2336 3346 M16823 GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION.html A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. 13/30 Gene Ontology BP GO:0034629 0.0114222784031831 0.0136403391527724 3160 3202.45454545455 3156 0.00104381971978614 1967 1.80427858197251 -1.05602749128711 -1 3.12386497732667 3660 3156 1967 2973 3644 4422 2901 3837 2533 2976 3158 3347 M14220 GO_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_METHYLATION.html The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. 16/38 Gene Ontology BP GO:0051568 0.000249843497664273 0.000351096658491289 1985 2796.54545454545 3158 2.27156250645061e-05 705 1.14486941424747 -1.14486941424747 -1 3.67129669925632 1982 4198 3158 4491 4630 705 1679 1258 3749 4007 905 3348 M10258 GO_EMBRYONIC_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEMOPOIESIS.html The stages of blood cell formation that take place within the embryo. 15/26 Gene Ontology BP GO:0035162 0.000223778498241794 0.00031590257444106 4175 3248.63636363636 3159 2.0345569424816e-05 1789 1.19511595827196 1.32012553031565 1 3.88331527344589 3295 2323 2552 1789 3159 4618 4175 3898 3155 2600 4171 3349 M11118 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS.html A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. 8/27 Gene Ontology BP GO:0002087 0.000205955280579693 0.000292163265423621 2800 3126 3161 2.05974370979779e-05 2330 1.15045956965138 1.15045956965138 1 3.77444439215478 2799 2408 3694 3161 3160 3266 2330 3450 3871 2909 3338 3350 M12069 GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 69/221 Gene Ontology BP GO:0002263 4.28229170234548e-06 7.9946442999558e-06 2400 3240 3162 3.89300003439349e-07 2396 1.57929396573996 -1.21777941074941 -1 7.47246438186763 4150 3387 2396 3309 2400 3162 3702 2953 2687 3130 4364 3351 M16077 GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 386/855 Gene Ontology BP GO:1903827 2.08405243698729e-08 1.05867127625077e-07 2795 3067.36363636364 3163 1.89459314248131e-09 770 1.38059989192475 -1.04325458462177 -1 8.93914644620227 3442 3711 2792 2770 770 2347 3631 3163 2791 3889 4435 3352 M13528 GO_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neuroblast proliferation. 14/44 Gene Ontology BP GO:1902692 0.000237092052325913 0.000333682448908522 3390 3087.45454545455 3164 2.15561461256582e-05 1537 1.35037907948192 -0.940613870276727 -1 4.35800649221599 3387 2661 2335 1537 3164 4283 4336 4464 2617 1902 3276 3353 M14055 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 21/31 Gene Ontology BP GO:2001267 3.79000181312902e-06 7.1678119830379e-06 3800 2846.18181818182 3164 3.44546212935216e-07 1677 1.64735820064237 -1.05124207825762 -1 7.86701389708153 3799 2233 2310 1677 2376 3711 3164 3518 1759 3249 3512 3354 M10286 GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-4 production. 24/68 Gene Ontology BP GO:0032673 0.000829260482681389 0.00110065539728099 3215 2972.81818181818 3165 7.54157478495423e-05 1802 1.60511713417335 -1.52353610421787 -1 4.40783374972599 3211 2687 1802 3218 3328 2855 3999 3165 3358 2159 2919 3355 M11789 GO_SEQUESTERING_OF_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUESTERING_OF_METAL_ION.html The process of binding or confining metal ions such that they are separated from other components of a biological system. 8/22 Gene Ontology BP GO:0051238 0.000223162717816388 0.000315224976824305 4460 3453.81818181818 3167 2.23185131703731e-05 2235 1.17929840058223 -0.775125792074244 -1 3.8329398000856 4457 3069 3805 2684 3167 3625 4528 2235 2908 2914 4600 3356 M15865 GO_GERM_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. 110/412 Gene Ontology BP GO:0007281 7.86975952139406e-06 1.39749245682363e-05 4525 3271 3167 7.15435242995539e-07 2229 1.49695962980215 -1.68347385390683 -1 6.7458579098675 4524 4003 2822 3425 2530 2306 4579 2229 2858 3538 3167 3357 M12437 GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of granulocyte differentiation. 7/21 Gene Ontology BP GO:0030852 0.0033938553822227 0.00424277612807216 2805 2913.09090909091 3168 0.000339904976518592 1884 1.48584048044756 -1.48584048044756 -1 3.27205083415035 2801 3415 3908 3168 3519 1884 2213 2058 3218 3555 2305 3358 M16559 GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. 20/64 Gene Ontology BP GO:0034308 0.0513827523672454 0.0579334918021176 3580 3273.45454545455 3168 0.00478396417129948 2029 1.45397242384503 -1.34744486759475 -1 1.66962768509896 3579 3006 2029 3450 4384 3095 4394 2329 3784 3168 2790 3359 M15559 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 27/54 Gene Ontology BP GO:1901030 2.32982323916936e-05 3.78759429252918e-05 3015 3499.27272727273 3169 2.11804355691762e-06 2620 1.41440767029073 2.00418784242294 1 5.80532811644419 3012 4374 2820 4466 2764 4623 3169 2620 2876 4049 3719 3360 M12537 GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE.html Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. 7/13 Gene Ontology BP GO:0099500 8.34462882265228e-05 0.000123981157195438 3380 3243.27272727273 3170 8.34494218694935e-06 2197 0.906640528907982 -0.906640528907982 -1 3.28782063267828 3379 2197 3926 2987 3019 3205 3961 2247 3170 4421 3164 3361 M14681 GO_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMETE_GENERATION.html The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. 272/1037 Gene Ontology BP GO:0007276 1.53270591489662e-07 4.60513862791122e-07 3045 3241.18181818182 3170 1.39336911061625e-08 1470 1.51177447346758 1.65089977727466 1 8.89248647834959 3042 4401 2676 3170 1470 3064 3364 3510 2699 3680 4577 3362 M15644 GO_GTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GTP, guanosine triphosphate. 14/28 Gene Ontology BP GO:0046039 4.24468742795275e-07 1.06071494768486e-06 3610 2975.72727272727 3170 3.858807497204e-08 1784 0.879430911517314 -0.774262149728306 -1 4.8771402255426 3610 2659 2936 3566 1784 2489 3170 2035 3691 3617 3176 3363 M15771 GO_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_CHECKPOINT.html A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. 126/269 Gene Ontology BP GO:0000075 0.0138517931023428 0.0164191665494454 1840 3075.36363636364 3170 0.00126725312118782 1828 1.26445447730709 -1.15804261812506 -1 2.09471568744778 1840 4156 3170 3380 3667 1828 2495 2995 3633 4106 2559 3364 M15350 GO_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_CAPPING.html Any process that modulates the frequency, rate or extent of telomere capping. 10/26 Gene Ontology BP GO:1904353 1.34132330757333e-05 2.27456687986229e-05 3050 2991.63636363636 3171 1.21939225962688e-06 422 0.329102895817792 -0.329102895817792 -1 1.41843337495447 3049 4588 3171 3923 4309 998 1394 2049 4437 4568 422 3365 M15910 GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE.html Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. 7/13 Gene Ontology BP GO:0031629 8.34462882265228e-05 0.000123981157195438 3380 3305.27272727273 3171 8.34494218694935e-06 2194 0.906640528907982 -0.906640528907982 -1 3.28782063267828 3380 2198 4478 2988 3020 3206 3962 2194 3171 4596 3165 3366 M12262 GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 18/62 Gene Ontology BP GO:0045072 0.000670623219061011 0.000898097377011905 3175 2953 3172 6.09843392338451e-05 1733 1.39109790982014 -1.48236659459435 -1 3.9341704389454 3172 2920 2603 3365 3294 2163 3658 1733 3671 3474 2430 3367 M10537 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 15/23 Gene Ontology BP GO:1902254 9.80144770389649e-08 3.22295479385208e-07 3940 2795 3173 8.91040740051907e-09 1083 1.11792623674053 -0.907669777504504 -1 6.73664687043391 3940 1083 2395 1455 1328 4026 3879 3182 2485 3173 3799 3368 M11931 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. 38/109 Gene Ontology BP GO:0034121 1.49117107447975e-05 2.50217105125026e-05 3055 3379.81818181818 3173 1.35561925618933e-06 2441 1.44149927141769 1.50293484335305 1 6.15744091672543 3623 3051 2441 3052 2679 4444 3511 3629 3173 3004 4571 3369 M11257 GO_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOOD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. 7/27 Gene Ontology BP GO:0032094 0.0438704293075675 0.0497898810254305 2065 3014.45454545455 3174 0.00447613619908448 1667 1.21907478952994 1.21907478952994 1 1.47433718831383 2064 3304 3717 3174 4252 2456 1667 3136 3587 3547 2255 3370 M11321 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION.html The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. 18/23 Gene Ontology BP GO:0006295 0.000253431391583387 0.000355756227782994 2565 3031.27272727273 3174 2.30418718724734e-05 1278 0.554904359272267 -0.472701998249631 -1 1.77648366669905 2564 3748 3367 3829 3174 1278 2116 2759 4056 4360 2093 3371 M11920 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. 33/99 Gene Ontology BP GO:1990542 0.0839184282471183 0.0891201423493528 2370 3158.18181818182 3174 0.00793650793650794 1961 0.764855677820494 -0.660974808037795 -1 0.745500256610457 2370 3174 3349 3245 3877 1961 2681 3019 4083 4114 2867 3372 M12487 GO_LIPOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOXYGENASE_PATHWAY.html The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. 6/15 Gene Ontology BP GO:0019372 0.00187609242545947 0.0024029509328023 3700 3273.54545454545 3175 0.000187767818522568 2534 2.06181276224369 -2.26964057164696 -1 5.01298200721238 3696 2808 3917 4434 3440 2710 2700 3029 3566 2534 3175 3373 M16455 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION.html The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 18/23 Gene Ontology BP GO:0006293 0.000253431391583387 0.000355756227782994 2565 3056.45454545455 3175 2.30418718724734e-05 1279 0.554904359272267 -0.472701998249631 -1 1.77648366669905 2565 3749 3368 3830 3175 1279 2117 2760 4057 4627 2094 3374 M11249 GO_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 29/78 Gene Ontology BP GO:0006801 3.15280544525556e-06 6.07657770125428e-06 3890 3011 3176 2.86619087593568e-07 2217 1.35800109999133 -1.26870985291062 -1 6.57559747483294 3888 3176 2306 3540 2333 2452 3685 3574 3585 2217 2365 3375 M15219 GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. 9/22 Gene Ontology BP GO:0010310 0.0765897756730953 0.0843068583333764 2335 3153.72727272727 3176 0.00793650793650794 1665 1.64000261468393 -1.46436957468099 -1 1.63520928068282 2331 2484 4372 4240 3942 2468 4008 3419 3176 1665 2586 3376 M14937 GO_REGULATION_OF_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cilium assembly. 32/66 Gene Ontology BP GO:1902017 9.41809070417803e-05 0.000138952002349853 2450 2790.09090909091 3178 8.56226719284361e-06 914 0.953355559423473 -1.03513558589395 -1 3.41341333426021 2449 4290 3178 4390 3776 924 1690 914 3849 4108 1123 3377 M15852 GO_POSITIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AUTOPHAGY.html Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 56/126 Gene Ontology BP GO:0010508 6.39752788377968e-06 1.15309479675423e-05 4360 3277.45454545455 3178 5.81595135241527e-07 1778 1.17055757136763 -1.09388926398359 -1 5.36568115076285 4356 1778 3019 2758 2488 2518 4586 3980 3178 3699 3692 3378 M13286 GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 48/104 Gene Ontology BP GO:0042158 1.17408570380944e-05 2.01154240693256e-05 2825 3056.81818181818 3181 1.06735633605626e-06 897 1.07973591767143 -0.845591774687236 -1 4.70715283084883 2822 3768 3236 4552 2620 897 2812 3843 3181 4154 1740 3379 M14428 GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 12/35 Gene Ontology BP GO:0051569 0.00346712103030796 0.00433086977232172 2690 3130.54545454545 3183 0.000315690652245759 1992 0.9083912751629 -0.949898278790625 -1 1.99289241532275 2689 3826 2982 3183 3511 1992 3344 2728 3981 3902 2298 3380 M11402 GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. 6/17 Gene Ontology BP GO:0045835 0.000235639708077926 0.000331738982597275 1800 2628.81818181818 3184 2.35664698539956e-05 536 1.36036572466762 1.36036572466762 1 4.39343933144951 1797 3764 3738 3092 3240 1427 536 3811 3184 3417 911 3381 M14123 GO_RNA_SECONDARY_STRUCTURE_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SECONDARY_STRUCTURE_UNWINDING.html The process in which a secondary structure of RNA are broken or 'melted'. 22/45 Gene Ontology BP GO:0010501 0.011970956457497 0.0142625483274721 1720 2948.54545454545 3184 0.00109423592026552 1335 1.04803816616326 -1.04803816616326 -1 1.79569059755401 1719 3295 3324 3184 3848 1335 2438 2774 4208 4097 2212 3382 M10974 GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. 56/165 Gene Ontology BP GO:0048525 3.93221723317376e-06 7.41563144338983e-06 3185 3090.18181818182 3185 3.5747493286584e-07 1584 1.34302702876139 -1.34914788380668 -1 6.39526736195821 3185 4158 2524 4097 2380 1584 4033 2411 3815 3225 2580 3383 M11963 GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 9/20 Gene Ontology BP GO:0051974 0.000493093329077062 0.000671781786063615 2200 2816.36363636364 3185 4.93202776722311e-05 709 2.6251163596807 2.6251163596807 1 7.73137115613458 2200 3217 3834 3049 3269 3473 3361 1610 709 3073 3185 3384 M16451 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 14/48 Gene Ontology BP GO:0032786 0.009504915594119 0.0114152413614833 2880 3351.90909090909 3185 0.000867839172845994 2141 0.616646787822032 -0.66924610256858 -1 1.11191066345316 2879 3932 3174 3185 3633 2141 2606 3354 4490 4625 2852 3385 M10804 GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 8/15 Gene Ontology BP GO:0044090 0.00071868101089817 0.000958310147501495 3190 3029.90909090909 3186 7.18913542823397e-05 1977 1.35528605978416 -1.16011360249908 -1 3.7974354002364 3186 2445 3640 2399 3323 2604 3541 3617 1977 2904 3693 3386 M14826 GO_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_SIGNALING.html A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. 11/20 Gene Ontology BP GO:0031929 0.0337506614680436 0.038701981031397 3075 3287.54545454545 3187 0.00311634895025005 2586 1.25246160861022 -1.25246160861022 -1 1.64191345488122 3073 3187 3059 4117 3750 2586 3121 3522 3631 3325 2792 3387 M16535 GO_CORTICAL_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. 29/61 Gene Ontology BP GO:0030865 0.000271045543409988 0.000379284044018256 4000 2929.36363636364 3187 2.46435402422601e-05 1418 1.71284705499888 -1.72110669249398 -1 5.43932843396798 3996 2313 1890 1418 3187 3713 3583 4128 1729 1854 4412 3388 M10932 GO_T_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 25/50 Gene Ontology BP GO:0043029 2.74180020451789e-06 5.36233291894547e-06 4150 3195.90909090909 3190 2.49254874686811e-07 1738 1.06041066288051 -0.802622926989127 -1 5.18808494230675 4480 1738 2690 1861 2300 3241 4147 4148 3190 3149 4211 3389 M11412 GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. 765/2173 Gene Ontology BP GO:0051172 5.07518503912114e-08 1.98918106430085e-07 3740 3149.90909090909 3191 5.0751851550299e-09 1117 1.48566058072884 -1.19172583032103 -1 9.24164874868632 3191 3739 3740 4586 1117 1998 3089 3431 2615 2842 4301 3390 M13702 GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. 20/36 Gene Ontology BP GO:0000959 0.000603832131081054 0.000812871146595921 3210 2562.45454545455 3191 5.49089025532034e-05 1164 1.01796046079756 -1.01796046079756 -1 2.91981577029633 1265 3210 3191 3206 3646 1164 1727 1250 3760 3914 1854 3391 M15477 GO_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of organelle assembly. 91/202 Gene Ontology BP GO:1902115 0.00043616113403922 0.000597902611557159 2505 2848 3192 3.96588753817927e-05 655 1.18261683198649 -1.05365973059955 -1 3.5385331788566 2503 4091 3192 4127 3283 655 2183 2056 3667 4024 1547 3392 M15803 GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. 8/33 Gene Ontology BP GO:0002825 6.31658863522017e-06 1.14205299974016e-05 3410 3135.18181818182 3192 6.3166065899734e-07 1532 1.92032020768937 1.68158222998454 1 8.80994293764384 3408 2446 4460 3258 2506 3187 1609 4583 3192 1532 4306 3393 M16416 GO_LEUKOTRIENE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_METABOLIC_PROCESS.html The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 19/54 Gene Ontology BP GO:0006691 1.65272397940835e-06 3.45191067763966e-06 3350 2956.90909090909 3192 1.50247747363545e-07 1226 1.49986607779577 1.52867500589879 1 7.60446340671554 3350 1468 1860 3192 2150 4380 3536 4220 2881 1226 4263 3394 M12136 GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 10/22 Gene Ontology BP GO:0002082 0.00961732567720933 0.0115472570776527 3995 2966.81818181818 3193 0.000878147913222993 1457 1.04747159835814 -1.04747159835814 -1 1.88389982936965 1796 3993 3042 3433 4317 1457 2229 3417 3993 3193 1765 3395 M13525 GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. 16/23 Gene Ontology BP GO:0006488 5.75759750285528e-05 8.75041741595976e-05 960 2345.81818181818 3193 5.23431653624713e-06 356 0.688759140424721 -0.688759140424721 -1 2.59445084636504 956 3272 3193 4092 3647 380 356 877 3908 4006 1117 3396 M12134 GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 11/26 Gene Ontology BP GO:0071257 0.000704561418431832 0.00094056315864836 3195 2760.18181818182 3194 6.40715599183502e-05 1446 2.02811275801991 2.43850750120956 1 5.69794140172777 3194 2066 1480 2311 3305 4216 3642 3701 1715 1446 3286 3397 M16610 GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. 16/23 Gene Ontology BP GO:0006490 5.75759750285528e-05 8.75041741595976e-05 960 2356.45454545455 3194 5.23431653624713e-06 357 0.688759140424721 -0.688759140424721 -1 2.59445084636504 957 3273 3194 4093 3648 381 357 981 3909 4010 1118 3398 M15006 GO_REGULATION_OF_TRANSLATIONAL_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_FIDELITY.html Any process that modulates the ability of the translational apparatus to interpret the genetic code. 12/16 Gene Ontology BP GO:0006450 0.0839184282471183 0.0891201423493528 2195 3191.18181818182 3195 0.00793650793650794 2034 0.518865275719251 -0.518865275719251 -1 0.505734816724149 2193 3555 3341 3122 3871 2034 2490 3195 3966 4545 2791 3399 M16738 GO_V_D_J_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_V_D_J_RECOMBINATION.html The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). 7/17 Gene Ontology BP GO:0033151 3.48775036397795e-05 5.50242097857615e-05 3775 3228.54545454545 3195 3.48780510499884e-06 1733 1.52225681384924 -0.967122612887604 -1 6.01880384762182 3771 2744 4613 2318 2858 3195 3394 4178 1733 2761 3949 3400 M14989 GO_LYTIC_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. 40/73 Gene Ontology BP GO:0080171 9.86335656426084e-05 0.000145222448019946 3265 2945.36363636364 3196 8.96708981837545e-06 1622 1.0315938330104 -0.892799131118397 -1 3.67518331615298 3262 1838 2934 3626 3023 1622 3196 3275 3430 3483 2710 3401 M16410 GO_LYSOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. 40/73 Gene Ontology BP GO:0007040 9.86335656426084e-05 0.000145222448019946 3265 2946.36363636364 3197 8.96708981837545e-06 1623 1.0315938330104 -0.892799131118397 -1 3.67518331615298 3263 1839 2935 3627 3024 1623 3197 3276 3431 3484 2711 3402 M14774 GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. 154/403 Gene Ontology BP GO:0002831 2.73448444812755e-07 7.36012248849637e-07 3235 2819.81818181818 3199 2.48589526182697e-08 977 1.40523539484931 -1.23640315455384 -1 8.0001718573857 3235 3199 2567 4087 1661 977 3596 3356 2537 3629 2174 3403 M15357 GO_GOLGI_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_VESICLE_TRANSPORT.html The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. 209/431 Gene Ontology BP GO:0048193 6.52250417206259e-08 2.35260304034061e-07 3635 3076.36363636364 3199 5.92954942312740e-09 990 1.33927942414708 -1.14800885150971 -1 8.2404779380306 3635 3138 3199 3904 1186 990 3981 4632 2768 4112 2295 3404 M13533 GO_REGULATION_OF_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_DUPLICATION.html Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 20/42 Gene Ontology BP GO:0010824 0.0768094491914599 0.0845286258819503 2920 3520.18181818182 3200 0.00723909050755993 1930 0.49227174192176 -0.49227174192176 -1 0.490311464904919 2916 4636 3200 4425 4078 1930 2974 2913 4609 4477 2564 3405 M12579 GO_MAINTENANCE_OF_LOCATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION_IN_CELL.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. 59/136 Gene Ontology BP GO:0051651 3.02832565540264e-08 1.3822254686434e-07 4390 3033.90909090909 3202 2.753023360989e-09 902 1.29241029848809 -1.01290944712831 -1 8.2291884353745 4387 3202 2744 2618 902 2011 3738 3293 2926 3348 4204 3406 M13418 GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 5/19 Gene Ontology BP GO:0001963 0.000278581355335155 0.000389359793143024 3170 3353 3204 2.78616284905299e-05 2553 0.678657906030477 -0.678657906030477 -1 2.14797723573531 3167 3501 4072 3530 3204 2632 3103 2603 4051 4467 2553 3407 M15770 GO_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_KILLING.html Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 31/141 Gene Ontology BP GO:0001906 4.60698769156688e-08 1.86002120451696e-07 3085 2984.36363636364 3204 4.18817071640104e-09 1046 1.15681773105304 -0.782040766564885 -1 7.22736919807536 3081 3745 2790 3204 1046 4615 1994 3480 3338 3235 2300 3408 M13489 GO_LIPID_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSLOCATION.html The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. 10/30 Gene Ontology BP GO:0034204 0.0839184282471183 0.0891201423493528 3120 3182 3205 0.00793650793650794 1861 2.70620925029641 2.70620925029641 1 2.63772649512836 3120 3061 1861 1870 3888 4388 3325 3976 2695 3205 3613 3409 M13966 GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of T cell proliferation. 42/104 Gene Ontology BP GO:0042130 0.000306560428657729 0.000427050726149966 4495 3236.54545454545 3205 2.78730140777421e-05 1885 1.57454149333162 -1.58139452663804 -1 4.92483111127791 4494 2547 1885 3047 3205 3231 4182 3311 2755 2980 3965 3410 M15235 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 12/22 Gene Ontology BP GO:0030812 5.82228359821235e-06 1.06052815796391e-05 3445 2998.63636363636 3205 5.29299909718144e-07 2013 1.2663583441486 -1.10389902789237 -1 5.84754052312747 3445 2013 2173 3205 2468 4428 3708 2139 3271 2185 3950 3411 M11434 GO_RETINOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. 10/44 Gene Ontology BP GO:0042572 0.0129859298259731 0.0154243213563554 2570 3129.63636363636 3207 0.00118756557202868 1278 1.73424040391992 -1.48187060274341 -1 2.91666945524865 2566 3431 2277 3506 4307 2793 1278 4092 3779 3190 3207 3412 M13951 GO_INTERSTRAND_CROSS_LINK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTRAND_CROSS_LINK_REPAIR.html Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. 25/49 Gene Ontology BP GO:0036297 0.0320787177815201 0.0368393486667321 1360 3069.90909090909 3207 0.00295965837146131 1357 0.875690942099411 -0.875690942099411 -1 1.16539886615546 1357 3980 3207 3831 3751 1630 2451 2777 4273 4018 2494 3413 M12032 GO_NEGATIVE_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_AGING.html Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 14/27 Gene Ontology BP GO:0090344 0.000368729898427892 0.000509679344567045 3140 2931.09090909091 3210 3.35265194293733e-05 774 1.54355015015149 -0.64780270893198 -1 4.71783146723944 3137 3669 2386 2806 3610 3982 3549 1151 774 3968 3210 3414 M15281 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT.html Any process that modulates the frequency, rate or extent of actin filament-based movement. 25/71 Gene Ontology BP GO:1903115 4.68559995880337e-05 7.22525427058255e-05 3635 3190.81818181818 3210 4.25972705139825e-06 1846 1.84748881527799 -2.18381388352966 -1 7.10185139528959 4565 3923 1988 3181 2904 4061 3635 2155 3210 1846 3631 3415 M16372 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. 34/86 Gene Ontology BP GO:0032109 6.17623639485333e-08 2.28921327882059e-07 4220 3040.27272727273 3211 5.61476051658523e-09 1157 1.11793453708745 -0.988161793088824 -1 6.89087072107673 4219 1844 2743 2381 1157 3322 3569 3211 3142 3717 4138 3416 M11445 GO_HIPPO_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPO_SIGNALING.html The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. 13/37 Gene Ontology BP GO:0035329 0.00143704769526668 0.00186322603996738 2385 2937.90909090909 3214 0.000130726112650803 1280 1.54611607413022 -1.54611607413022 -1 3.91770396769675 2384 3825 2546 3214 4469 1697 3531 1663 4205 3503 1280 3417 M12374 GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. 7/37 Gene Ontology BP GO:0033081 0.13771800063521 0.14483005140414 2790 3224.63636363636 3214 0.0147080557647901 2028 1.58072490908711 -1.19306608944343 -1 1.23129033767219 2786 3648 3899 2947 4140 3214 2028 2651 4129 2723 3306 3418 M15344 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. 7/31 Gene Ontology BP GO:0035235 6.3952348907072e-05 9.65000831899692e-05 3975 3307.36363636364 3214 6.39541894379385e-06 1703 1.44431296984745 -1.40112013759283 -1 5.38352919624712 3973 1703 4392 2175 2979 4324 3214 4557 2854 1978 4232 3419 M15490 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN.html The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. 10/41 Gene Ontology BP GO:0003081 4.4737330331684e-05 6.92154031089666e-05 3260 3083.81818181818 3214 4.067112736174e-06 1325 2.6334153716677 2.03383382626067 1 10.1685882720905 3258 3301 2188 3209 2893 3298 2805 4377 1325 3214 4054 3420 M12392 GO_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that modulates the frequency, rate or extent of thymocyte aggregation. 7/37 Gene Ontology BP GO:2000398 0.13771800063521 0.14483005140414 2790 3225.81818181818 3215 0.0147080557647901 2029 1.58072490908711 -1.19306608944343 -1 1.23129033767219 2787 3649 3902 2948 4141 3215 2029 2652 4130 2724 3307 3421 M13815 GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. 53/135 Gene Ontology BP GO:0046434 2.03438770800221e-07 5.72464371409349e-07 4050 3207.45454545455 3215 1.84944354193316e-08 1580 1.48946578268827 -1.04839483763938 -1 8.63059878178558 4050 4125 2354 4433 1580 2404 3720 3675 2716 3010 3215 3422 M14618 GO_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 7/33 Gene Ontology BP GO:0072215 2.96073217959526e-07 7.86423312921098e-07 4425 2735 3215 2.9607325740624e-08 857 2.86295822131344 -3.11983106560484 -1 16.2226993585509 4422 1764 4260 1704 1708 3853 3712 3215 857 1315 3275 3423 M16203 GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 14/38 Gene Ontology BP GO:0071549 0.000436129226894669 0.000597902611557159 3615 3184.90909090909 3215 3.96559735817143e-05 1092 2.40770195863087 -2.14330027774235 -1 7.20413686389871 3612 3215 1092 2286 3239 4518 3162 4505 2551 2448 4406 3424 M11432 GO_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 28/50 Gene Ontology BP GO:0044088 8.86753307762049e-06 1.54898254625252e-05 3590 3194.09090909091 3216 8.06142620014533e-07 2152 1.1748971562441 -0.956012903933125 -1 5.24577735100779 3586 2947 3036 4012 2565 2152 3324 3977 2952 3368 3216 3425 M10589 GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 49/133 Gene Ontology BP GO:0032481 9.7674530563429e-08 3.21633223692199e-07 3145 2717 3217 8.87950317272141e-09 1043 1.13691610129144 -1.17181063520944 -1 6.85202295199184 3141 3546 3217 3978 1327 1043 3227 1531 3464 3627 1786 3426 M14902 GO_ORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT.html The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 12/23 Gene Ontology BP GO:0015695 0.000154758581116647 0.000222735304440357 4320 3203.36363636364 3218 1.40699516956199e-05 990 1.5573671083072 -2.02553184402135 -1 5.27978182490578 4320 4012 1905 4595 3218 4612 2979 990 3045 2184 3377 3427 M10344 GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. 9/23 Gene Ontology BP GO:0046337 0.000323429445017212 0.000449605662639197 3895 3457.36363636364 3219 3.23476527634495e-05 2403 1.39998601456279 -1.44791763418247 -1 4.34981072288412 3894 2403 3569 3201 3219 4525 3028 3598 3046 3061 4487 3428 M11294 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 5/18 Gene Ontology BP GO:0033145 0.000222851668141385 0.000314881404498007 1790 2708.09090909091 3219 2.22874019585816e-05 750 0.678657906030477 -0.678657906030477 -1 2.20606307042209 1790 2746 3726 3219 3947 750 1373 3243 3735 4359 901 3429 M12098 GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 14/26 Gene Ontology BP GO:0002068 5.05973610384146e-06 9.32976756558216e-06 3465 3088.09090909091 3219 4.59977067333185e-07 459 1.78662279350854 2.13906970342685 1 8.34221041940736 3464 3958 2406 3163 2437 4453 3913 3456 459 3041 3219 3430 M14061 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. 34/86 Gene Ontology BP GO:0032106 6.17623639485333e-08 2.28921327882059e-07 4220 3040 3219 5.61476051658523e-09 1156 1.11793453708745 -0.988161793088824 -1 6.89087072107673 4218 1843 2742 2380 1156 3321 3568 3219 3141 3715 4137 3431 M13573 GO_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 90/182 Gene Ontology BP GO:0009411 1.12240028145875e-05 1.9286841253934e-05 3510 3321.72727272727 3220 1.02036909798477e-06 1786 1.32420721540141 1.82388334249676 1 5.7953907476418 3510 3626 2824 3190 2612 3220 4305 1786 3160 3875 4431 3432 M16546 GO_RESPONSE_TO_MANGANESE_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MANGANESE_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. 10/30 Gene Ontology BP GO:0010042 0.00631058296402542 0.00768424775818778 3960 3064.81818181818 3220 0.000575341596688927 1742 2.20073162069176 -2.59507780919083 -1 4.31939654209018 3958 3941 2030 3357 3760 2643 3188 1742 2489 3220 3385 3433 M12489 GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS.html The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. 18/42 Gene Ontology BP GO:0006904 0.000363887787284173 0.000503435934553163 3940 3232.72727272727 3221 3.30861808684937e-05 2186 0.723741606019797 -0.583073895028005 -1 2.21569837803705 3938 2822 3111 2995 3221 2491 3383 2186 3958 4043 3412 3434 M13762 GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. 13/45 Gene Ontology BP GO:0031664 0.0908324843647613 0.0963305675892158 2970 3332.72727272727 3221 0.00861953839108861 2517 1.47872697835066 -1.47872697835066 -1 1.39492738334033 2966 4176 3005 3606 3867 2517 3221 2898 4145 3517 2742 3435 M11631 GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that activates or increases the rate of neuroblast proliferation. 11/33 Gene Ontology BP GO:0002052 0.000372223105085764 0.000514201689054806 3860 3157.36363636364 3222 3.38441906634617e-05 1684 1.44236699700889 -0.977892051157174 -1 4.40343047918322 3856 2830 2257 1684 3222 3984 4001 4249 2783 2010 3855 3436 M16089 GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. 68/204 Gene Ontology BP GO:0002698 0.000199808682476198 0.000283964405490354 4170 3348 3222 1.81660756212512e-05 2214 1.52972074695154 -1.37576398620953 -1 5.03628334982127 4169 3627 2308 3222 3138 2634 4633 4618 2653 2214 3612 3437 M11655 GO_UV_PROTECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_UV_PROTECTION.html Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. 8/13 Gene Ontology BP GO:0009650 2.86905788815679e-07 7.64833009489568e-07 3230 2733 3223 2.86905825857404e-08 1261 1.09155589022343 -0.509301442945895 -1 6.19745461448179 3228 1261 3784 2470 1699 4447 3481 1435 1392 3643 3223 3438 M13744 GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 13/57 Gene Ontology BP GO:2000514 0.00010764018700733 0.000157706970108877 3225 3179.18181818182 3223 9.78595035618576e-06 1647 1.73966562148126 1.738663540917 1 6.13993896479589 4641 2757 1647 3223 3037 3923 3808 2815 3586 2309 3225 3439 M14333 GO_HISTONE_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_UBIQUITINATION.html The modification of histones by addition of ubiquitin groups. 24/40 Gene Ontology BP GO:0016574 0.0238728059551207 0.0277034336539928 3005 3385 3223 0.00219416921944402 1644 0.697331051500111 -0.71712194121854 -1 1.00815369195765 3004 4226 3223 4140 3716 1644 2936 2813 4518 4510 2505 3440 M14906 GO_URATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. 6/18 Gene Ontology BP GO:0046415 7.52346649030616e-05 0.000112464439518646 1990 2941.72727272727 3223 7.52372121390961e-06 543 0.637327634218739 0.637327634218739 1 2.33623923686936 1989 3223 4314 4381 4530 1395 543 2250 4492 4538 704 3441 M11491 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. 5/21 Gene Ontology BP GO:0002674 0.0765897756730953 0.0843068583333764 3125 3257.81818181818 3225 0.00793650793650794 2267 1.70201126707489 1.70201126707489 1 1.6970367043751 3121 3225 3758 2826 4108 3461 3081 2706 3556 2267 3727 3442 M14757 GO_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLATION.html The covalent attachment of a fucosyl group to an acceptor molecule. 9/29 Gene Ontology BP GO:0036065 1.05153113474789e-05 1.81902349427513e-05 2560 3283.18181818182 3225 1.0515361105108e-06 2358 1.21862572346553 1.08611491821582 1 5.36207177611359 2560 3065 4288 4173 2618 3225 3022 4049 3264 2358 3493 3443 M12767 GO_POSITIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIVISION.html Any process that activates or increases the frequency, rate or extent of cell division. 61/192 Gene Ontology BP GO:0051781 4.46537263433288e-08 1.82025681661173e-07 3270 3082.18181818182 3226 4.05942974997018e-09 1035 1.96944926579051 -1.83514652213522 -1 12.3215482128518 3266 4491 1581 2800 1035 4391 2381 3674 2483 3226 4576 3444 M13049 GO_CILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 109/278 Gene Ontology BP GO:0044782 3.21978303008675e-07 8.42416530555108e-07 4610 3354.27272727273 3226 2.92707591028568e-08 1704 1.16606770847674 -1.15237293787657 -1 6.57508712775608 4610 2502 3226 3951 1704 2556 4539 3743 2913 3982 3171 3445 M14814 GO_FEMALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GAMETE_GENERATION.html Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. 47/155 Gene Ontology BP GO:0007292 4.78192800464689e-07 1.17101749607466e-06 1830 2972.81818181818 3226 4.34720822186256e-08 1826 1.74341312806332 -1.81398460723184 -1 9.59907398052754 3441 3511 1827 2294 1826 3964 3841 3226 2178 2243 4350 3446 M14305 GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. 13/27 Gene Ontology BP GO:0035883 0.000391966306034471 0.000539806038111738 3645 3019.27272727273 3228 3.56396507931459e-05 478 2.06073772097287 2.5959279158674 1 6.25089640969778 3641 4010 2094 2488 3228 4306 4211 2376 478 2964 3416 3447 M11639 GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. 72/188 Gene Ontology BP GO:0034249 1.84869361048351e-06 3.78744100229785e-06 3695 2957.54545454545 3229 1.6806319672462e-07 1151 1.69183599053034 -1.34021907481001 -1 8.51450097386466 3693 3840 2675 3229 2188 1151 3319 3891 2207 3695 2645 3448 M13467 GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 8/35 Gene Ontology BP GO:0043949 0.000359125678073332 0.000497143865025188 2540 3169.27272727273 3229 3.59183728340776e-05 1835 1.27802591683968 1.70267678491895 1 3.91909189503268 2540 3647 4081 4094 3229 3081 1835 2593 3755 3652 2355 3449 M14406 GO_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_GENE_SILENCING.html The inactivation of gene expression by a posttranscriptional mechanism. 21/58 Gene Ontology BP GO:0016441 0.00247409371937664 0.00312492305197654 2520 2962.09090909091 3229 0.000225170949462813 1260 0.96029108666324 -0.862659422470363 -1 2.2330969871725 2518 3604 3229 3065 4096 1260 1903 3561 3980 3951 1416 3450 M15340 GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. 131/336 Gene Ontology BP GO:0002218 3.67313431593425e-07 9.42229979496284e-07 3725 3176.18181818182 3229 3.33921357200299e-08 1276 1.35742137067927 -1.2352708629098 -1 7.59279423983214 3725 3172 3027 4357 1737 1276 3744 4585 3229 3830 2256 3451 M16083 GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI.html The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. 10/21 Gene Ontology BP GO:0000301 2.04247176629536e-05 3.3521372961857e-05 3230 3286.54545454545 3229 1.85680975343024e-06 2118 0.803719548648681 -0.803719548648681 -1 3.33837758520883 3229 3407 2904 3953 2735 2118 3606 2868 4424 4602 2306 3452 M12761 GO_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_MODIFICATION.html The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. 279/725 Gene Ontology BP GO:0016568 0.000570874841575033 0.000771412074922258 2050 3055 3230 5.19111846277913e-05 699 1.31547943403778 -1.05129459287565 -1 3.80095160797769 2046 4601 3426 4299 4568 699 2203 2823 3230 4204 1506 3453 M10758 GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 59/128 Gene Ontology BP GO:0006661 0.000130982715539866 0.000189751247504399 2610 3037.54545454545 3233 1.19082285987459e-05 1161 1.10883580294271 -1.10397353560101 -1 3.83081503614214 2609 3685 3291 4598 3071 1161 3233 2435 3802 4079 1449 3454 M12077 GO_NEGATIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BINDING.html Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 25/89 Gene Ontology BP GO:0043392 3.97713095149209e-05 6.21744747736625e-05 3235 3460 3233 3.61563895578183e-06 2588 1.11347284297132 1.30594948625983 1 4.34768497143171 3233 3178 2588 3573 2868 4519 2953 4132 3593 3150 4273 3455 M12745 GO_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. 19/43 Gene Ontology BP GO:0031440 0.00140822472195302 0.00182738607714586 1995 2736.54545454545 3233 0.00012810244893077 849 0.890635473469818 -1.01030453801083 -1 2.26375514535589 1993 3747 3233 4194 3729 849 1205 1661 4238 3880 1373 3456 M16226 GO_NEGATIVE_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_SILENCING.html Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 8/26 Gene Ontology BP GO:0060969 0.00014385467979774 0.000207492164740885 2285 2686.81818181818 3233 1.43863993022265e-05 960 1.50046990852511 -1.50046990852511 -1 5.12977047253511 2281 3907 4531 3645 3233 960 1195 993 4112 3662 1036 3457 M11912 GO_FOREBRAIN_GENERATION_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_GENERATION_OF_NEURONS.html The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. 24/114 Gene Ontology BP GO:0021872 0.000523014554435443 0.000709768225379455 4030 3122.72727272727 3236 4.75580849198262e-05 1735 1.53221533731482 -1.29463974924856 -1 4.47863339043734 4030 2591 1735 2799 3261 3236 4587 3541 3084 1748 3738 3458 M14984 GO_POSITIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_REMODELING.html Any process that activates or increases the frequency, rate or extent of bone remodeling. 4/15 Gene Ontology BP GO:0046852 0.277413918988178 0.286611665745908 3095 3542.81818181818 3236 0.0319696823235775 2501 1.60043826348591 -1.60043826348591 -1 0.806255501270336 3094 3947 4330 4335 4035 2501 2912 3236 4387 3122 3072 3459 M16620 GO_ALCOHOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 31/86 Gene Ontology BP GO:0046164 8.43241647707633e-08 2.86825712110369e-07 2915 3070.27272727273 3236 7.6658334548035e-09 1279 1.86086448131528 -1.28438768098531 -1 11.3010754363246 2914 3633 1429 4084 1279 4490 2319 3320 3233 3236 3836 3460 M16965 GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. 13/42 Gene Ontology BP GO:0048025 0.209990748832014 0.218999785900054 2875 3567.36363636364 3237 0.0212002848930981 2309 0.256149625971397 -0.284062872939399 -1 0.156824598068589 2873 4455 3237 3990 4254 2309 3158 2875 4556 4642 2892 3461 M13501 GO_POSITIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_RESORPTION.html Any process that activates or increases the frequency, rate or extent of bone resorption. 4/15 Gene Ontology BP GO:0045780 0.277413918988178 0.286611665745908 3095 3519.90909090909 3238 0.0319696823235775 2500 1.60043826348591 -1.60043826348591 -1 0.806255501270336 3093 3946 4088 4334 4034 2500 2911 3238 4386 3118 3071 3462 M14887 GO_INTERACTION_WITH_SYMBIONT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_SYMBIONT.html An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 24/80 Gene Ontology BP GO:0051702 0.000897134088529193 0.0011857083897071 2075 3159.81818181818 3238 8.15909216582018e-05 2074 1.98538894445842 2.05141091919317 1 5.39252699787004 2074 4570 2400 4401 3343 3542 2081 2510 3238 3494 3105 3463 M10058 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 24/48 Gene Ontology BP GO:0042992 0.000535952112963512 0.000725911802943287 3655 2874.90909090909 3239 4.87347930245087e-05 1245 1.39256060786147 -0.723059147564062 -1 4.05779974475541 3655 3239 2615 2054 3267 4058 2582 1557 1245 3827 3525 3464 M16612 GO_REGULATION_OF_GONADOTROPIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GONADOTROPIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. 2/14 Gene Ontology BP GO:0032276 0.00195766131243046 0.00250217312519348 3465 3084.5 3239.5 0.00021770741339954 1581 2.93822246783395 2.93822246783395 1 7.09591043246996 3017 1581 4592 NA 3463 3640 3462 3549 2153 2588 2800 3465 M15547 GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. 19/53 Gene Ontology BP GO:0045414 1.58513226150788e-06 3.33022014958504e-06 4115 3131.36363636364 3240 1.44103036692734e-07 2135 1.24172398571229 -1.36229475015544 -1 6.31362422386092 4111 2271 2509 3479 2135 3240 4464 2409 3496 3028 3303 3466 M11214 GO_RESPONSE_TO_POTASSIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_POTASSIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. 5/20 Gene Ontology BP GO:0035864 0.000399904707442951 0.000550150387157813 3570 2998.81818181818 3241 3.99976691373969e-05 275 2.78101593050443 -1.79853554857737 -1 8.4144564870521 3568 4026 3710 1601 3241 4596 2924 4308 275 2263 2475 3467 M12145 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. 19/48 Gene Ontology BP GO:0001916 0.0336690581178515 0.0386179438836919 2305 3075.09090909091 3242 0.00310869555933382 2019 1.1759478018454 -1.00181679044781 -1 1.54263824251396 2303 3518 2746 3541 3749 2019 2765 3242 3861 3527 2555 3468 M13468 GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION.html The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). 7/22 Gene Ontology BP GO:0042074 0.000186377887673223 0.00026609856471918 2995 3297.27272727273 3242 1.86393521041263e-05 2414 1.66229580164068 -1.74666645914289 -1 5.51630554480911 2994 4108 4082 3242 3142 3425 2414 3172 3712 2732 3247 3469 M10598 GO_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_PROTEIN_TRANSPORT.html The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. 469/1034 Gene Ontology BP GO:0006886 1.79758229145829e-05 2.9829072835028e-05 1940 2838.90909090909 3244 1.63417907214827e-06 256 1.17028276851842 -1.08000294719639 -1 4.91601378476691 1936 4467 3495 4517 3244 256 2464 2372 3282 4270 925 3470 M12612 GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. 16/40 Gene Ontology BP GO:0045822 5.68713629180719e-06 1.03798256721921e-05 2840 3055.27272727273 3244 5.17013726678185e-07 2205 1.22357470406206 -1.27470488563618 -1 5.66058203172355 2836 3244 2205 3872 2463 2474 3524 3503 3836 3255 2396 3471 M13047 GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. 6/22 Gene Ontology BP GO:1903055 5.77487698906903e-07 1.3792568858152e-06 4300 2797.72727272727 3244 5.77487848978376e-08 1080 1.2531827682393 -0.944650574186242 -1 6.81722231228475 4300 1341 3999 1080 1895 3244 3398 4232 1583 1729 3974 3472 M15362 GO_NUCLEOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPHAGY.html A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. 14/20 Gene Ontology BP GO:0044804 0.000298839620253507 0.000416670377428539 3245 3202.09090909091 3245 2.7170929200961e-05 1891 1.07651367430704 -1.19650222181557 -1 3.37778506914708 3245 3753 2919 4547 3199 2121 4148 1909 3516 3975 1891 3473 M16551 GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 26/71 Gene Ontology BP GO:0006636 0.00209981203707538 0.00267400638731239 1800 2891.72727272727 3245 0.000191074445989691 1132 1.4616331609328 1.34620353083078 1 3.49075904187883 1798 3516 2333 4481 3444 2483 1132 3618 3770 3245 1989 3474 M16762 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of macrophage differentiation. 10/17 Gene Ontology BP GO:0045651 0.00045302531634625 0.000619557155757183 3565 3070 3245 4.119260277209e-05 1661 1.76254745717659 1.17111310253088 1 5.24847686799745 3561 2190 1661 2398 3245 4465 3815 3277 2808 2506 3844 3475 M12204 GO_CITRULLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CITRULLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 3/13 Gene Ontology BP GO:0000052 0.00794343922499607 0.00959203857520332 4415 3414.18181818182 3246 0.000797197710162971 2500 2.10913702625544 -2.10913702625544 -1 3.95106567696856 4413 2500 3869 3079 3627 4442 3706 3100 2724 2850 3246 3476 M12337 GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS.html The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. 113/269 Gene Ontology BP GO:0015980 0.00360680122015876 0.00449567196381131 2865 3238.18181818182 3246 0.000328429819698777 1778 1.10043880719953 -0.701907453530863 -1 2.39765170618758 2865 3466 3398 3246 3517 1778 2713 4597 2752 4159 3129 3477 M14822 GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY.html The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 13/26 Gene Ontology BP GO:0035058 1.38266479993707e-05 2.33869313883709e-05 4445 3432.63636363636 3246 1.25697589985506e-06 2630 0.999866836548618 -0.873173849039389 -1 4.29821936058375 4443 2630 3006 3087 2656 3246 4026 4212 3054 3518 3881 3478 M10078 GO_MITOTIC_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CYTOKINESIS.html A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. 19/56 Gene Ontology BP GO:0000281 0.0839184282471183 0.0891201423493528 4075 3276.90909090909 3248 0.00793650793650794 1726 2.61818765006539 -1.06970872304874 -1 2.55193234414274 4073 4574 1726 3466 4066 2619 3248 3162 1906 3018 4188 3479 M14168 GO_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING.html Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. 113/252 Gene Ontology BP GO:0016458 0.00222212142636334 0.00281816710805927 2230 3271.72727272727 3248 0.00020221537005789 2015 1.37187564066539 -1.23979406770917 -1 3.24735452292439 2227 4432 3248 4072 3454 2015 3095 2942 3595 4012 2897 3480 M15952 GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT.html The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. 6/23 Gene Ontology BP GO:0060841 0.00161614809054325 0.00208612054055945 3330 3065.72727272727 3249 0.000161732466561029 1776 2.31289294322859 -2.11532840688171 -1 5.75528042275002 3327 2248 4486 1776 3420 3721 3249 2915 1866 2552 4163 3481 M12715 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX.html The joining of the small ribosomal subunit, ternary complex, and mRNA. 10/23 Gene Ontology BP GO:0001731 0.0218671641325685 0.0254331771211212 3035 3224.45454545455 3250 0.00200796262898322 1516 0.699358123029034 -0.699358123029034 -1 1.03519048696555 3031 4210 3250 3908 4121 1516 2221 3030 4357 3804 2021 3482 M15991 GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of autophagosome assembly. 24/43 Gene Ontology BP GO:2000785 0.000337691276102622 0.000468589538238038 3275 3221.18181818182 3250 3.07039201378231e-05 2211 1.1492295882251 -1.01295981708853 -1 3.5515404794967 3274 3207 3049 4174 3213 2211 3379 3317 3250 3495 2864 3483 M12329 GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 10/22 Gene Ontology BP GO:0098911 0.000222842228456693 0.000314881404498007 4290 2994.63636363636 3251 2.02604367068876e-05 1061 1.66858082792757 -2.19425289300834 -1 5.42393260819588 4287 3251 2237 2752 3535 4474 3392 1061 2226 1866 3860 3484 M12760 GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. 11/16 Gene Ontology BP GO:0070243 0.000474113207760092 0.000647062793542066 4520 2996 3251 4.31104920763797e-05 1120 2.55139167432346 -1.46986627429316 -1 7.5528016478038 4517 3451 1427 2460 3251 3342 3942 2907 1120 2019 4520 3485 M14090 GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. 4/18 Gene Ontology BP GO:0070296 0.000105910884946571 0.000155369427743106 2645 3283.72727272727 3251 1.05915932987179e-05 2086 1.81522396086287 -2.26443913398563 -1 6.41754072857391 3493 2645 4183 2641 3054 3097 4319 4045 3307 2086 3251 3486 M10838 GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). 9/33 Gene Ontology BP GO:0042744 9.23842655849059e-07 2.07719198600832e-06 3600 3196.81818181818 3253 9.23843039917645e-08 2026 1.38899949817868 -1.51523099593523 -1 7.3267681500689 3598 3303 3645 2788 2026 3092 3586 3253 3561 3064 3249 3487 M13749 GO_POSITIVE_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_URINE_VOLUME.html Any process that increases the amount of urine excreted from the body over a unit of time. 9/17 Gene Ontology BP GO:0035810 2.78575986482901e-05 4.46934452398103e-05 3255 2874.63636363636 3254 2.78579478750627e-06 1138 2.1444532412111 2.03580424426353 1 8.65865878420912 3254 2019 4127 1138 2813 3703 3356 3289 1181 2352 4389 3488 M14692 GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT.html The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. 9/24 Gene Ontology BP GO:0060749 4.41196626619858e-06 8.21691110066586e-06 4175 2730.18181818182 3254 4.4119750256739e-07 976 2.32177718473598 -3.00509687787145 -1 10.9598729202102 4171 976 4274 1002 2432 4399 3645 3254 1078 1140 3661 3489 M11426 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. 40/88 Gene Ontology BP GO:1903363 0.00108953734633246 0.00142659952031066 1630 2741.36363636364 3257 9.90979370774228e-05 801 1.3141652344421 -1.37625380975331 -1 3.47142581004177 1629 4557 3257 3847 4041 801 1297 1569 3830 4104 1223 3490 M14074 GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 166/421 Gene Ontology BP GO:0045089 6.09964517889549e-08 2.26928305814197e-07 2970 2964.54545454545 3258 5.54513213455653e-09 1154 1.3846974927251 -1.23401236597298 -1 8.54006032815581 2967 3439 2987 4540 1154 1199 3343 3870 3258 3693 2160 3491 M12704 GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 20/39 Gene Ontology BP GO:0042558 2.68989178086234e-05 4.33350712648989e-05 3090 3233 3259 2.44538606376597e-06 2426 1.30624776040602 -1.06195515424346 -1 5.29048968261179 3088 3476 2592 3866 2786 2426 3259 3542 3191 3601 3736 3492 M10513 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 67/192 Gene Ontology BP GO:1903555 1.54754688759697e-05 2.59021636593826e-05 3225 3179.45454545455 3260 1.40687070329045e-06 1542 1.62522007351963 -1.12053329686667 -1 6.91955602236193 3221 3545 1542 3796 2687 4619 3389 2425 3260 2176 4314 3493 M15000 GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 16/34 Gene Ontology BP GO:0050858 2.3335856939438e-05 3.79238305109592e-05 3490 3071.18181818182 3260 2.12146404285411e-06 1268 1.98888488771614 -2.0473329101603 -1 8.1622129148825 3488 3400 1504 3260 2765 4079 2231 4224 3095 1268 4469 3494 M15302 GO_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. 13/24 Gene Ontology BP GO:0055070 0.0839184282471183 0.0891201423493528 3430 3188.90909090909 3260 0.00793650793650794 1560 0.935716682602831 -0.856135511195647 -1 0.912037502052223 3426 1560 2823 2126 4547 4152 3260 3268 2781 2969 4166 3495 M14530 GO_STRAND_DISPLACEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRAND_DISPLACEMENT.html The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. 13/27 Gene Ontology BP GO:0000732 0.391463104728958 0.402115751162954 2335 3570.90909090909 3262 0.044150055019217 2334 0.329102895817792 -0.329102895817792 -1 0.12086765392924 2334 4306 3098 4143 4267 2621 2925 3199 4602 4523 3262 3496 M16038 GO_PEPTIDYL_ARGININE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_METHYLATION.html The addition of a methyl group to an arginine residue in a protein. 8/14 Gene Ontology BP GO:0018216 0.0026182663813049 0.00330252942363452 2905 3400.81818181818 3262 0.000262135639999426 2129 0.619837739351021 -0.531116058198114 -1 1.42758078705922 2901 3018 4498 3715 3485 2129 2687 3262 4128 4600 2986 3497 M11582 GO_RESPONSE_TO_GRAVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GRAVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. 6/20 Gene Ontology BP GO:0009629 0.000425834808201251 0.000584091880200416 3390 3030.72727272727 3263 4.25916431093171e-05 937 3.75921276362515 3.75921276362515 1 11.2834377033116 3389 2807 3772 2117 3249 3848 4038 2499 937 3419 3263 3498 M12936 GO_RESPONSE_TO_ISCHEMIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISCHEMIA.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. 23/46 Gene Ontology BP GO:0002931 0.0151807882790482 0.0179486630964147 4475 3076.90909090909 3264 0.00138968767544416 1623 1.38534400950662 -1.25427938463134 -1 2.24524111939985 4475 1902 2388 2417 3676 3467 4151 3264 3348 1623 3135 3499 M13081 GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). 20/42 Gene Ontology BP GO:0072350 0.00978199181603314 0.0117388958391941 2590 3242.63636363636 3264 0.000893250796446057 1517 0.656791952954357 -0.660925788098879 -1 1.17689595077162 2586 3893 3264 4131 3634 1517 2588 3000 4363 4076 2617 3500 M10842 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. 35/89 Gene Ontology BP GO:0002720 0.000526157330825464 0.000713477945976235 3885 3194.36363636364 3265 4.78439281852238e-05 1787 1.9563357174067 -1.29744616614855 -1 5.71421705597685 3885 3657 1787 2884 3265 2854 4569 3762 2538 2391 3546 3501 M16846 GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY.html Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. 7/22 Gene Ontology BP GO:0051482 1.48336456523473e-08 8.70405107804676e-08 4320 2894.54545454545 3265 1.48336457513639e-09 679 3.22844737419062 -4.18510391895501 -1 21.1584907731286 4317 2161 4625 1072 679 3966 4552 3265 1362 1323 4518 3502 M12368 GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. 26/79 Gene Ontology BP GO:1903018 0.020233198025674 0.0235977740349672 2140 2905.18181818182 3266 0.00185651933233849 1948 1.68411326102885 1.76900642826121 1 2.54367943207145 2140 3426 2177 3647 3852 3343 2360 2042 3756 1948 3266 3503 M16194 GO_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TISSUE_REMODELING.html Any process that modulates the frequency, rate, or extent of tissue remodeling. 32/85 Gene Ontology BP GO:0034103 4.02742921943403e-05 6.28761058030673e-05 3250 3346.81818181818 3266 3.6613663176749e-06 1925 1.71335768178345 1.52032689580461 1 6.68225458537571 3247 3266 1925 3537 2873 4603 3393 4594 3008 2113 4256 3504 M10481 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. 5/19 Gene Ontology BP GO:2001028 0.0063624227424944 0.00774331029971206 2170 2949.27272727273 3267 0.000638071267595796 1779 1.41079000662912 1.41079000662912 1 2.7646159256679 2166 3417 3595 3649 4288 2508 1884 1779 3949 3267 1940 3505 M12728 GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. 24/51 Gene Ontology BP GO:1901224 4.2972614075951e-05 6.66183129063908e-05 4295 3248.72727272727 3268 3.90667758938649e-06 1966 1.55380326463325 -1.07680218159852 -1 6.02376341686506 4295 3268 2045 1966 2884 3476 4496 3893 2739 2617 4057 3506 M13690 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER.html The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. 12/39 Gene Ontology BP GO:0048791 2.28911259167605e-05 3.72663035173629e-05 3985 3187.63636363636 3268 2.08103310033687e-06 775 1.30214032204893 -1.16881174464555 -1 5.35305339399876 3985 3247 1766 3775 2759 3268 4288 4366 3697 775 3138 3507 M11987 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. 23/58 Gene Ontology BP GO:0032715 0.0707762309798843 0.0790127531713399 3115 3378.09090909091 3269 0.00665102864714943 2461 1.18412350174685 1.09339405577287 1 1.21162153171039 3112 3269 2620 3067 3847 4300 2913 3679 3761 2461 4130 3508 M14054 GO_VITAMIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORT.html The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 15/42 Gene Ontology BP GO:0051180 0.000152003530800983 0.000218905829252159 2290 2919.72727272727 3269 1.38194576475507e-05 1161 1.75862962468003 1.62717369141227 1 5.97439677961486 2290 2730 1161 3694 3095 3831 3293 3801 3269 1561 3392 3509 M10341 GO_PINOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PINOCYTOSIS.html An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. 9/23 Gene Ontology BP GO:0006907 0.004560063809199 0.00562496712702204 1780 2971.09090909091 3270 0.0004569448305234 1018 1.04003152929798 0.679004651565821 1 2.17207573627357 1779 2741 3568 3952 3768 1643 1018 3270 4293 3735 2915 3510 M12630 GO_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 57/139 Gene Ontology BP GO:0055076 5.55114338009657e-08 2.12306084957071e-07 4045 3347.36363636364 3270 5.0464941092415e-09 1115 1.27426550814098 -1.07053821886283 -1 7.89319129080521 4041 2504 2785 4175 1115 3270 4607 4315 3069 2678 4262 3511 M12855 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. 3/14 Gene Ontology BP GO:0046929 0.0176848920884693 0.0207508096959219 3270 3423 3270 0.00178272288642643 2696 0.710644061081929 -0.710644061081929 -1 1.11018732678067 3270 2994 3969 3050 3699 2873 2696 3994 3629 4436 3043 3512 M12325 GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. 4/31 Gene Ontology BP GO:0021895 0.192702144546708 0.20133124597893 2625 3452.09090909091 3272 0.0211787710554011 2623 0.37709016032916 -0.468218784175321 -1 0.243656856438642 3272 3808 3891 2625 4316 2623 2630 3155 4454 4412 2787 3513 M16008 GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of ARF protein signal transduction. 8/16 Gene Ontology BP GO:0032012 0.0140973317918727 0.0166974264055268 3400 3050.09090909091 3272 0.00141875691515768 770 1.83237313726523 -2.2871190364993 -1 3.02312497225887 3398 3458 4493 1990 3772 2916 4626 3272 770 2940 1916 3514 M14363 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 8/12 Gene Ontology BP GO:1900102 4.64879141884965e-06 8.60619559717661e-06 4205 3465.27272727273 3274 4.64880114394603e-07 2141 1.17453084797846 -1.11454594695567 -1 5.52241691580459 4204 2935 4229 3274 2439 4360 3163 3251 3827 2141 4295 3515 M15563 GO_CAMP_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 3/14 Gene Ontology BP GO:0006198 0.0312490430527419 0.035922086381253 2840 3231.54545454545 3274 0.00316973679319149 1559 1.73184661339729 1.73184661339729 1 2.32240360869611 2838 4113 4423 3795 3919 2801 1559 2393 3571 2861 3274 3516 M11697 GO_ORGAN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. 11/46 Gene Ontology BP GO:0048799 0.0189488730207524 0.022149954037098 3695 3213 3275 0.001737643416392 1978 1.7478675676624 1.83846963491802 1 2.68458886685126 3080 3557 1978 3599 3695 3177 3173 3691 3275 2012 4106 3517 M12969 GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. 13/34 Gene Ontology BP GO:0030201 0.000576688768754446 0.000779041592472183 2750 3299.54545454545 3275 5.2439999309701e-05 1819 1.02001807886264 0.594286450672625 1 2.94319732602226 2747 3324 2938 4185 3275 2654 1819 4463 3752 3940 3198 3518 M13141 GO_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 5/19 Gene Ontology BP GO:0070528 0.01932571086665 0.0225677252399035 3460 3311.09090909091 3276 0.00194958646058833 1825 2.00627611875977 -2.00627611875977 -1 3.06637152858704 3457 1825 4019 2860 3705 3003 3844 4394 2931 3276 3108 3519 M14436 GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. 16/59 Gene Ontology BP GO:0046597 0.000577972256638025 0.000780548338443964 3575 3161.72727272727 3276 5.25567412995555e-05 2002 1.29448467244274 0.976851570732673 1 3.734144942119 3267 3480 2513 3572 3276 3824 2002 2071 3942 3259 3573 3520 M15432 GO_NEUTROPHIL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a neutrophil. 13/36 Gene Ontology BP GO:0002446 0.00326439884418817 0.00408754148693789 3155 3415.27272727273 3276 0.000297204791178749 2508 1.14475927866276 1.37669412546176 1 2.53813900451202 3155 3276 2886 4255 3505 4553 3107 2508 2826 3944 3553 3521 M13428 GO_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRAND_BREAK_REPAIR.html The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. 93/195 Gene Ontology BP GO:0006302 0.0119931536627851 0.0142853290036714 1110 2956.72727272727 3277 0.00109627608321638 1108 1.20614978947643 -1.09053840907968 -1 2.06582034035883 1108 4254 3277 4290 3836 1336 2144 2078 3846 4121 2234 3522 M13562 GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 5/12 Gene Ontology BP GO:0060394 0.0123110462624132 0.0146527013064303 1705 2992.09090909091 3278 0.00123797856691154 1450 1.36575395285386 1.36575395285386 1 2.3252004096412 1701 3566 4097 3798 4591 2072 1450 1938 4187 3278 2235 3523 M14035 GO_MITOTIC_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_CHECKPOINT.html A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. 88/191 Gene Ontology BP GO:0007093 0.00555801053586047 0.00680354413867655 2115 3118.72727272727 3278 0.000506554725791616 1792 1.34664869711695 -1.20348331035855 -1 2.7091646543158 2115 4286 3086 3687 3581 1792 2454 3278 3349 4096 2582 3524 M12405 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY.html Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. 10/23 Gene Ontology BP GO:0035794 5.17381307057353e-06 9.52876401692698e-06 3245 3270.54545454545 3279 4.70347748912876e-07 2442 1.47728087525091 1.85692728682006 1 6.88524285141545 3241 3351 2714 3279 2442 4358 3792 3514 2582 3195 3508 3525 M15739 GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 13/55 Gene Ontology BP GO:0010866 5.0759743764705e-07 1.23004953183468e-06 3925 2976 3279 4.61452322511881e-08 1154 1.77003769238068 -1.20354205002244 -1 9.71057208016279 3924 2393 1154 2269 1842 4472 3279 3322 3799 1788 4494 3526 M11944 GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION.html The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. 6/13 Gene Ontology BP GO:0017187 6.91613165458777e-06 1.23839565261284e-05 3280 3153.36363636364 3280 6.91615317947673e-07 1637 1.28647524990523 -1.62831397765581 -1 5.86001951720944 3280 1637 3830 2632 2524 3330 3883 4185 2696 3423 3267 3527 M13040 GO_PROTEIN_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CARBOXYLATION.html The addition of a carboxy group to a protein amino acid. 6/13 Gene Ontology BP GO:0018214 6.91613165458777e-06 1.23839565261284e-05 3285 3170.54545454545 3281 6.91615317947673e-07 1638 1.28647524990523 -1.62831397765581 -1 5.86001951720944 3281 1638 3998 2633 2525 3331 3884 4189 2697 3432 3268 3528 M16070 GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS.html The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. 25/57 Gene Ontology BP GO:0006921 0.0878062486850154 0.0931850086044632 3160 3538.54545454545 3281 0.00832000150048351 2120 0.905229461608996 -0.970966598300953 -1 0.866045266355882 3159 4567 3070 4420 3864 2120 2959 3281 4452 4020 3012 3529 M13693 GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that activates or increases the frequency, rate or extent of receptor internalization. 8/32 Gene Ontology BP GO:0002092 0.011664765019685 0.013911394462285 3930 3362.09090909091 3283 0.00117264512628245 2916 1.81667659662675 -2.53204610565318 -1 3.13091980207746 3928 3283 4117 3096 3659 3259 3053 2916 3436 2926 3310 3530 M14075 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/23 Gene Ontology BP GO:0051590 0.000229847300833821 0.000323977236724781 4035 3578 3283 2.29871077696856e-05 2204 1.12118365208795 1.12118365208795 1 3.6316774801065 4031 2204 4180 2610 3172 4501 4507 3279 3132 3283 4459 3531 M14685 GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. 206/456 Gene Ontology BP GO:0034248 8.09332425469974e-05 0.00012047869353822 2675 3233.63636363636 3283 7.35783818721146e-06 1056 1.3809566675296 -0.992393623381423 -1 5.0238236397623 3283 4358 3304 4225 2995 1056 2941 4030 2673 4034 2671 3532 M14243 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. 5/13 Gene Ontology BP GO:0052803 0.00487768983857811 0.00600126603876663 1400 2784.18181818182 3284 0.000488842936620996 1042 2.40349173062465 2.40349173062465 1 4.95687922409526 1396 3332 4212 4315 3784 1411 1042 2037 3821 3284 1992 3533 M11776 GO_CRISTAE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRISTAE_FORMATION.html The assembly of cristae, the inwards folds of the inner mitochondrial membrane. 5/13 Gene Ontology BP GO:0042407 0.00217333962208678 0.0027608251341584 2425 2764.63636363636 3285 0.000217546808469094 1019 0.571387382365975 -0.571387382365975 -1 1.35726111494381 2425 3285 3803 3520 3596 1019 1099 1947 3931 4378 1408 3534 M14352 GO_CYCLOOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLOOXYGENASE_PATHWAY.html The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. 5/22 Gene Ontology BP GO:0019371 0.0156535497091569 0.0184840873091596 1895 3084.09090909091 3285 0.00157649205560771 1349 2.48628549932511 2.48628549932511 1 4.00008569888603 1894 3502 4227 3108 3939 2137 1349 4107 3731 3285 2646 3535 M10160 GO_CERAMIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. 6/13 Gene Ontology BP GO:0046514 0.000647221705213552 0.000868762757243863 3290 3101.54545454545 3286 6.47410285689677e-05 2119 1.57938358218148 -1.5728432186629 -1 4.48780615138238 3286 2700 3546 2119 3307 2893 3666 3592 2757 2518 3733 3536 M12372 GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 29/55 Gene Ontology BP GO:0006220 0.0381047443509859 0.0434586902534089 2110 3317.90909090909 3286 0.0035255629304664 1990 0.769563494845929 -0.807345169310841 -1 0.972895468590735 2106 3922 3219 4589 3765 1990 2730 3286 3969 4070 2851 3537 M10638 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. 129/330 Gene Ontology BP GO:0050688 4.056922894572e-06 7.61062343414053e-06 3365 2957.90909090909 3287 3.68811852343978e-07 1084 1.41768461063856 -1.14821707334689 -1 6.73594030398749 3363 3287 2485 4172 2390 1084 3687 3515 2516 3634 2404 3538 M11085 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 268/605 Gene Ontology BP GO:1903829 1.68344971250246e-08 9.32227361461289e-08 3070 3025.36363636364 3287 1.53040884125845e-09 685 1.49061332643933 -1.11324547766985 -1 9.72789772271032 3069 3543 2449 2896 685 3391 3430 3287 2500 3770 4259 3539 M12373 GO_GLYCOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 6/13 Gene Ontology BP GO:0019377 0.000647221705213552 0.000868762757243863 3290 3135.36363636364 3287 6.47410285689677e-05 2120 1.57938358218148 -1.5728432186629 -1 4.48780615138238 3287 2701 3898 2120 3308 2894 3667 3589 2758 2533 3734 3540 M12577 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. 14/40 Gene Ontology BP GO:0000027 0.0740767691007438 0.0825980881207381 2730 3142.36363636364 3287 0.00697230280921979 1945 1.11171111127698 -1.11171111127698 -1 1.11763887162517 2726 4172 3287 3436 3912 1945 2215 2739 3782 3969 2383 3541 M13323 GO_HEART_VALVE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_FORMATION.html The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. 9/24 Gene Ontology BP GO:0003188 0.000592233866952661 0.00079841516964611 3290 3150.27272727273 3287 5.92391759607407e-05 2350 2.30027469252181 2.92015112841417 1 6.61451751635523 2772 3490 4053 4183 3287 3287 2350 2925 2569 2351 3386 3542 M10195 GO_NUCLEOSOME_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_DISASSEMBLY.html The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. 17/41 Gene Ontology BP GO:0006337 0.557443745451391 0.569212955823798 2570 3374.72727272727 3288 0.0714285714285714 2569 1.18301434950984 -1.19040980855787 -1 0.268743246402712 2569 3521 2829 3007 4183 3121 3288 3804 4354 2825 3621 3543 M14111 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein. 20/58 Gene Ontology BP GO:0042517 3.35523638690372e-05 5.31322051309481e-05 4350 3262.36363636364 3288 3.05026141723307e-06 1999 1.35433653410017 -0.924325440059385 -1 5.37397305437715 4346 3004 1999 3662 2832 2548 4067 4084 3416 2640 3288 3544 M10543 GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-DNA complex into its constituent components. 17/41 Gene Ontology BP GO:0032986 0.557443745451391 0.569212955823798 2830 3374.81818181818 3289 0.0714285714285714 2570 1.18301434950984 -1.19040980855787 -1 0.268743246402712 2570 3522 2830 3008 4184 3122 3289 3795 4355 2826 3622 3545 M14300 GO_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 40/100 Gene Ontology BP GO:0046631 3.11065617225001e-06 6.00531251881779e-06 4270 3344.45454545455 3289 2.82787324593016e-07 2259 1.37048087004028 -1.10941700421598 -1 6.64254380253099 4270 2943 2259 3289 2329 3015 4584 4620 3294 2424 3762 3546 M11389 GO_RELAXATION_OF_CARDIAC_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_CARDIAC_MUSCLE.html The process in which the extent of cardiac muscle contraction is reduced. 14/30 Gene Ontology BP GO:0055119 8.72254792512994e-05 0.000129182743273934 3290 3315.63636363636 3290 7.92990343220786e-06 2260 2.03388488844273 -3.00447382713426 -1 7.34193617810224 3290 3869 2260 3887 3012 3659 2474 3329 3265 3037 4390 3547 M12941 GO_CHROMATIN_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DISASSEMBLY.html The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. 17/41 Gene Ontology BP GO:0031498 0.557443745451391 0.569212955823798 2575 3376.63636363636 3290 0.0714285714285714 2571 1.18301434950984 -1.19040980855787 -1 0.268743246402712 2571 3523 2831 3009 4185 3123 3290 3803 4356 2829 3623 3548 M15053 GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT.html The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. 9/24 Gene Ontology BP GO:0061377 4.41196626619858e-06 8.21691110066586e-06 4175 2740.45454545455 3290 4.4119750256739e-07 977 2.32177718473598 -3.00509687787145 -1 10.9598729202102 4172 977 4340 1003 2433 4400 3646 3290 1079 1143 3662 3549 M15528 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. 15/55 Gene Ontology BP GO:0046638 0.000217432510015881 0.000307692515697572 4325 3332 3290 1.97685456807399e-05 2228 1.48345821166811 -1.22825288241922 -1 4.83597990960816 4321 2825 2228 3290 3153 3075 4406 3735 3503 2610 3506 3550 M12552 GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 79/187 Gene Ontology BP GO:0042990 1.51985962143906e-05 2.54754809470815e-05 3295 3188.45454545455 3291 1.38170011038101e-06 1568 1.41667721838499 -1.03142203108605 -1 6.04114775724184 3291 3839 2872 3982 2682 1568 3833 3904 2498 3878 2726 3551 M14044 GO_REGULATION_OF_MITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOPHAGY.html Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy). 34/62 Gene Ontology BP GO:1903146 8.75087929676274e-06 1.53148633904521e-05 3435 3271.36363636364 3291 7.95537645917064e-07 2559 1.26978881959776 1.65350355406831 1 5.67527242181739 3431 3291 3039 4043 2559 3735 3099 2714 2903 3385 3786 3552 M15098 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. 5/16 Gene Ontology BP GO:0003198 0.000275734936379592 0.000385613647473026 1370 2753.36363636364 3291 2.75769155745357e-05 511 1.09002388354129 1.09002388354129 1 3.45421416336079 1370 3360 4352 4242 3321 1313 511 2710 3895 3291 1922 3553 M13947 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. 18/38 Gene Ontology BP GO:0070229 0.000664362223669769 0.000890226206204541 3090 3257.09090909091 3292 6.04148122285782e-05 1837 1.88398783231651 1.72542853545692 1 5.33480064751192 3087 3519 1837 3580 3292 4634 3473 4578 2718 1933 3177 3554 M13856 GO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING.html The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. 105/235 Gene Ontology BP GO:0006457 2.64040623753484e-05 4.25969637278467e-05 4160 3378.27272727273 3294 2.40039811619797e-06 1747 1.41021887277878 -0.945292017971671 -1 5.7213541691633 4157 4120 3242 2568 2780 1747 3294 4610 2928 3930 3785 3555 M15339 GO_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G2_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. 22/46 Gene Ontology BP GO:0031572 0.0347470925288801 0.0397954490901801 2785 3308.81818181818 3294 0.0032098493557726 2386 0.924645667213239 -0.888506941666527 -1 1.20177763634297 2781 3294 2827 3535 3756 2386 2926 3451 4244 3966 3231 3556 M14705 GO_ACTIVATION_OF_MAPKKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKKK_ACTIVITY.html Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). 7/13 Gene Ontology BP GO:0000185 6.83662934032699e-05 0.000102626802544902 3840 3370.63636363636 3295 6.83683967718766e-06 1819 1.42502506016314 1.34010410388863 1 5.27627312710585 3840 1819 4275 2823 2986 4579 3014 3705 3295 2745 3996 3557 M10281 GO_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGY.html Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 168/374 Gene Ontology BP GO:0010506 4.42092440095579e-08 1.81102323401297e-07 4035 3208.54545454545 3296 4.01902226344979e-09 1030 1.26997541099772 -1.00744394882339 -1 7.94800416097203 4033 2608 3214 4267 1030 1535 4107 4334 3296 3831 3039 3558 M16755 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 28/72 Gene Ontology BP GO:0032784 0.0109882993336004 0.0131457546523851 2650 3200.18181818182 3296 0.00100396084140048 1413 0.925554043541173 -0.80374085937545 -1 1.61625239820357 2650 4042 3296 3922 4461 1413 2163 3083 4216 4148 1808 3559 M11368 GO_POSTREPLICATION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTREPLICATION_REPAIR.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. 26/72 Gene Ontology BP GO:0006301 0.000563994167671865 0.000762558217967521 1635 2967.90909090909 3298 5.12853459714927e-05 1234 0.9253612438005 -1.06151117103052 -1 2.6780488751762 1633 4416 3298 4504 4396 1234 1959 1237 4243 4031 1696 3560 M10361 GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. 9/20 Gene Ontology BP GO:0002861 1.75289223569223e-05 2.91499951658991e-05 3815 3233.81818181818 3300 1.75290606268609e-06 1641 1.57693517122564 -1.37350612673371 -1 6.6388809189409 3812 3015 3573 3151 2724 4561 3357 3300 2424 1641 4014 3561 M12431 GO_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MEMBRANE.html A process in which a protein is transported to, or maintained in, a specific location in a membrane. 223/589 Gene Ontology BP GO:0072657 7.49069431735806e-06 1.3345853306022e-05 3065 3271.54545454545 3300 6.80974529295725e-07 2056 1.47404658664251 1.66166121560969 1 6.66997341124989 3062 3811 3300 2957 2521 2700 3548 3935 2056 3869 4228 3562 M13250 GO_POST_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_MORPHOGENESIS.html The process, occurring after embryonic development, by which anatomical structures are generated and organized. 6/17 Gene Ontology BP GO:0009886 0.0256051130290788 0.0296385449139856 3130 3270.09090909091 3300 0.0025905017844582 2140 1.95570987435906 1.95570987435906 1 2.77419873773345 3128 3499 4038 3162 4304 3647 2661 2140 2658 3434 3300 3563 M11242 GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html The directed killing of a target cell by a leukocyte. 26/73 Gene Ontology BP GO:0001909 1.69501795757011e-07 4.96214903972132e-07 3450 3153.72727272727 3301 1.5409255346954e-08 1507 1.05031030559012 -0.782040766564885 -1 6.14646915195063 3449 3395 2864 3460 1507 4565 2252 3301 3292 3238 3368 3564 M13067 GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 17/33 Gene Ontology BP GO:0010869 0.0587331171602091 0.0659806104463709 2910 3203.18181818182 3301 0.00548748511912564 2269 1.20316254396374 -0.633505682364423 -1 1.31853040922028 2910 3370 2269 3301 4232 3694 2829 2365 3834 2831 3600 3565 M14713 GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. 15/27 Gene Ontology BP GO:0009081 4.54974869462407e-06 8.44641470977192e-06 4260 3347 3303 4.13614373076284e-07 2415 1.1852762058242 -0.672816508557501 -1 5.58189418440003 4257 3213 2460 3141 2415 2539 3894 3890 3303 3690 4015 3566 M15724 GO_LONG_CHAIN_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_TRANSPORT.html The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 19/73 Gene Ontology BP GO:0015909 5.07690700112193e-05 7.78984772181399e-05 3595 3324.18181818182 3303 4.61547651266232e-06 1902 1.58049871013681 1.77127450907211 1 6.0275872075172 3594 2515 1902 3221 2919 4113 4437 3303 3636 3030 3896 3567 M11982 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 27/45 Gene Ontology BP GO:0071353 0.0116667682603546 0.013911394462285 4265 3265.90909090909 3304 0.0010662819362022 1895 1.79313056013463 -1.64049220762746 -1 3.09033979083549 4265 3977 2172 3016 4002 2970 4398 1895 3473 3304 2453 3568 M12953 GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION.html Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 10/19 Gene Ontology BP GO:0051127 0.000346268223956216 0.000479774205857568 4385 3353.27272727273 3304 3.14838851575987e-05 1872 0.909006913729794 -1.24841230658143 -1 2.80052027782588 4385 2336 2800 2991 3217 4602 3304 1872 3425 3806 4148 3569 M13550 GO_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. 334/846 Gene Ontology BP GO:0006325 0.0029868001668815 0.00375107199751983 1615 2909.36363636364 3306 0.000271896625426118 967 1.35161214514549 -1.15459383910815 -1 3.04357617043462 1615 4532 3406 4236 3649 967 2123 2237 3306 4140 1792 3570 M10466 GO_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DEGRANULATION.html The regulated exocytosis of secretory granules by a leukocyte. 20/68 Gene Ontology BP GO:0043299 0.0426245568635946 0.0484232487197626 3310 3289.18181818182 3307 0.00395213801800078 2267 1.13541139291066 -0.749986557292319 -1 1.38589481456075 3307 3211 2476 2746 3932 4405 2527 2267 3647 3598 4065 3571 M15005 GO_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 290/763 Gene Ontology BP GO:0043900 4.5645830226169e-08 1.84611140888591e-07 4470 3138.72727272727 3307 4.14962101574849e-09 1000 1.44675550126695 -1.24974502740657 -1 9.04317121682599 4469 3419 2390 4317 1044 1000 4448 4432 2857 3307 2843 3572 M11186 GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. 7/23 Gene Ontology BP GO:0031645 0.044736410883177 0.0507355045751322 3310 3277 3308 0.00456633912997428 1974 3.10631889590407 -2.74653942733724 -1 3.73319164471335 3308 3284 3703 2974 3791 4581 2480 3920 1974 2717 3315 3573 M12035 GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. 11/36 Gene Ontology BP GO:0060706 0.00139306104112699 0.00180821426165855 4315 3215.45454545455 3308 0.00012672217486093 1958 1.49001247669645 1.11860574409656 1 3.79354521737298 4313 2369 2271 3336 3393 3308 4346 1958 3086 2657 4333 3574 M12901 GO_G1_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage. 45/99 Gene Ontology BP GO:0044783 1.5948961865189e-06 3.34920985708154e-06 3795 3131.54545454545 3308 1.44990667522232e-07 2097 1.48253212662368 -1.34200332194827 -1 7.53463015630656 3794 3814 2534 3308 2137 2219 3475 4283 2097 3701 3085 3575 M15353 GO_SPERMATID_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_DIFFERENTIATION.html The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 70/283 Gene Ontology BP GO:0048515 4.55705804632454e-05 7.04341561554089e-05 4235 3446 3309 4.14286585773422e-06 2134 1.2869850242621 -1.46844136923329 -1 4.96046770960285 4231 4036 3102 4573 2896 2134 4423 2319 3309 3998 2885 3576 M15666 GO_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_EXTENSION.html Any process that modulates the frequency, rate or extent of dendrite extension. 7/29 Gene Ontology BP GO:1903859 0.00238933056747656 0.00302197271173894 3890 3266 3309 0.000239190346700409 1043 1.98009482053631 -1.03162437208451 -1 4.63132840498922 3887 3100 4436 2855 3476 3061 3629 3309 1043 2753 4377 3577 M10453 GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. 42/140 Gene Ontology BP GO:0046634 0.000717060136254377 0.000956423502622543 3020 3209.27272727273 3310 6.52085417249948e-05 1995 1.41205698830959 -1.13491814789949 -1 3.95762616674792 3018 3391 2433 3979 3310 1995 3612 4635 3729 2599 2601 3578 M11236 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. 2/18 Gene Ontology BP GO:0045955 0.158150628524436 0.165754710663422 2720 3410.9 3310.5 0.0189464577091156 2464 0.710644061081929 -0.710644061081929 -1 0.514888265051112 2716 2708 3713 NA 3951 2464 3276 3345 4439 4353 3144 3579 M14444 GO_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. 91/217 Gene Ontology BP GO:0035303 9.11765878316306e-06 1.58950294897295e-05 3470 3030.81818181818 3311 8.28881506410857e-07 1824 1.63192816379726 -1.00919743227869 -1 7.26937823971695 3467 3311 2054 1824 2572 3354 3730 3731 2099 3003 4194 3580 M13399 GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. 10/30 Gene Ontology BP GO:0033630 0.000942007289249814 0.00124218683441832 4385 3162.45454545455 3312 8.56737167931416e-05 1715 2.13071892144107 -1.86082132582945 -1 5.74728803987146 4383 2931 1715 2608 3349 4119 3845 3312 2797 1869 3859 3581 M14004 GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. 52/125 Gene Ontology BP GO:0060333 0.000460299053136074 0.000629134089994346 3315 3298.90909090909 3313 4.18541262066298e-05 2094 1.45309619999607 1.67772635315135 1 4.31801354475018 3313 3629 2417 3723 3246 4591 3007 2094 3494 2629 4145 3582 M16543 GO_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_PATTERNING.html The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. 19/52 Gene Ontology BP GO:0021532 0.000341081427116273 0.000473152395010713 4595 3555.90909090909 3313 3.1012210803845e-05 2798 1.25965398630881 -1.03046212290134 -1 3.88787146316504 4591 2919 2798 3057 3214 3674 4598 3313 3626 3032 4293 3583 M12177 GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of leukocyte differentiation. 132/409 Gene Ontology BP GO:1902105 6.76862963405505e-07 1.57764796139145e-06 3900 2996.09090909091 3316 6.15330156047843e-08 1580 1.60969522582829 -1.50345642650098 -1 8.66941427244911 3897 2648 1986 3547 1918 2497 4316 3832 3316 1580 3420 3584 M15568 GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 48/182 Gene Ontology BP GO:0033559 6.80797873095538e-09 5.53300965206403e-08 3480 2812.72727272727 3317 6.18907159274811e-10 337 1.3864534945528 1.36897366232162 1 9.33972031019505 3476 521 1944 3562 337 4280 3317 4412 2954 1774 4363 3585 M11777 GO_SYNAPTIC_VESICLE_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_RECYCLING.html The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. 15/39 Gene Ontology BP GO:0036465 0.000765239858928335 0.00101892992974025 4465 3093.63636363636 3318 6.95914697111185e-05 753 2.23416906835768 -1.66951459077615 -1 6.20477165229946 4462 3346 2082 2778 3318 3271 3696 3483 753 2603 4238 3586 M14184 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR.html Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. 38/91 Gene Ontology BP GO:0000731 0.0415411415923785 0.0472502499787882 1575 3154.45454545455 3318 0.00384971987440438 1571 0.768929463961864 -0.846949302028085 -1 0.946164610341645 1571 4260 3318 4150 4122 1721 2434 2359 4303 4141 2320 3587 M11514 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION.html A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. 14/25 Gene Ontology BP GO:0000132 0.00783978956755405 0.00947673599639507 3320 3444.72727272727 3319 0.000715260650452849 2536 1.87764406020291 2.20966895384343 1 3.52656191921113 3319 3246 2536 2989 3614 4638 3852 3095 3396 3038 4169 3588 M10860 GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. 19/40 Gene Ontology BP GO:0035872 0.0142336002304441 0.0168416426783771 4070 3371.90909090909 3320 0.00130241198965824 2192 1.03499137947553 -0.96456061495227 -1 1.70398320870692 4068 3320 3101 3295 3671 4245 2192 3232 3590 3020 3357 3589 M13224 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. 22/63 Gene Ontology BP GO:1903312 0.0169257250015837 0.019920441364348 4455 3229.36363636364 3320 0.00155066939326477 1442 0.92435994266353 -0.92435994266353 -1 1.45927847574559 1872 4453 3320 4230 4450 1442 1950 2545 4520 4454 2287 3590 M13734 GO_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_BURST.html A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 8/26 Gene Ontology BP GO:0045730 0.00709432377940908 0.00860474015355182 2980 3211.45454545455 3320 0.000711707430934545 2285 2.25349095486878 2.25349095486878 1 4.32016312565941 2979 3761 4124 3354 3613 3320 2343 2285 3193 2927 3427 3591 M12430 GO_DNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_MODIFICATION.html The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. 35/83 Gene Ontology BP GO:0006304 0.0150380424045828 0.0177844194815278 2590 3170.18181818182 3322 0.00137652992021564 1398 0.943797052585135 -0.7248853529036 -1 1.53311911730397 2590 4367 3322 4348 4289 1398 2728 2031 3564 4051 2184 3592 M13794 GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. 16/51 Gene Ontology BP GO:0045589 0.0839184282471183 0.0891201423493528 3150 3422.90909090909 3322 0.00793650793650794 2569 1.20400016260111 -0.903096587444651 -1 1.17353187763173 3146 3322 2569 3426 3984 2742 3518 4514 3856 3257 3318 3593 M14438 GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of B cell proliferation. 13/36 Gene Ontology BP GO:0030889 0.000672413027289303 0.000900234626788995 2695 3001.90909090909 3324 6.11471484661336e-05 1102 0.996662221326884 -0.996662221326884 -1 2.81770995434718 2692 3374 2818 4482 3946 1533 1728 3324 4079 3943 1102 3594 M14569 GO_REGULATION_OF_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_ORGANIZATION.html Any process that modulates the frequency, rate or extent of chromatin organization. 88/225 Gene Ontology BP GO:1902275 6.38440001583401e-06 1.15117550576766e-05 2590 3271.27272727273 3324 5.80401685767108e-07 2015 1.33216745676724 1.41328428983927 1 6.10737417056346 2587 4359 2930 3853 2487 4176 2015 2535 3324 3694 4024 3595 M13119 GO_GAS_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAS_TRANSPORT.html The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/23 Gene Ontology BP GO:0015669 9.01161369794717e-05 0.000133378777174271 3690 3418 3325 9.01197916012204e-06 2134 2.11416825928776 -2.07958611198898 -1 7.60450001621512 3687 2764 4016 3325 3026 3884 4600 3284 3253 2134 3625 3596 M14131 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. 10/23 Gene Ontology BP GO:1903019 0.000128798063717844 0.000186819559463277 4430 3187.90909090909 3325 1.17096004330691e-05 1696 1.29228368779578 1.35975788692693 1 4.47270420259595 4427 1696 2189 3194 3064 3349 4556 3325 3730 1874 3663 3597 M12063 GO_PEPTIDYL_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_AMINO_ACID_MODIFICATION.html The alteration of an amino acid residue in a peptide. 446/1025 Gene Ontology BP GO:0018193 9.43394817370593e-09 6.64805736677504e-08 3330 3141.81818181818 3326 8.57631655832747e-10 457 1.44139180073457 1.75055070166328 1 9.60312533126548 3326 4115 3190 3751 457 1774 3298 3497 2664 3995 4493 3598 M15481 GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 44/104 Gene Ontology BP GO:0046916 6.82296878140007e-08 2.43497648363109e-07 2695 3218.09090909091 3326 6.20269908454927e-09 1201 1.19184128054775 -0.92683797569325 -1 7.3167674994684 2694 2879 2732 3794 1201 4403 3454 4350 3326 2766 3800 3599 M10043 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY.html A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. 18/46 Gene Ontology BP GO:0045005 0.476035888592635 0.487802831766851 4300 3661.18181818182 3328 0.0570645613008631 2597 0.293458591950925 -0.316047622196041 -1 0.0849237782915674 2597 4582 3249 4071 4298 2709 3328 3308 4560 4299 3272 3600 M14393 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 26/56 Gene Ontology BP GO:0032206 0.00487804825119648 0.00600126603876663 2130 3193.81818181818 3328 0.000444445274225892 1082 0.621236924702275 -0.621236924702275 -1 1.28121765625339 2127 4417 3328 3763 4397 1082 1781 3039 4489 4517 2192 3601 M14517 GO_CELLULAR_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 39/108 Gene Ontology BP GO:0071277 4.52399526921488e-07 1.11787706412798e-06 3895 3001.09090909091 3328 4.11272381773828e-08 1492 1.65792695893635 -1.53116291305857 -1 9.15943522470348 3893 3574 1492 2790 1804 3328 4200 3390 3406 1998 3137 3602 M16293 GO_UTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. 6/13 Gene Ontology BP GO:0046051 0.0238139528025937 0.0276489579550994 2055 3150.27272727273 3330 0.00240730663940974 1577 0.46603115888249 -0.46603115888249 -1 0.674125807385328 2052 3330 4542 3414 3806 1577 1696 3033 4177 4613 2413 3603 M16875 GO_TRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. 32/58 Gene Ontology BP GO:0006400 0.0105837319807422 0.0126813593771835 1595 2978.72727272727 3330 0.000966817604581527 1425 0.892500339859428 -0.892500339859428 -1 1.57147271580463 1594 3815 3330 4025 3730 1425 2725 2259 4069 4003 1791 3604 M12282 GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 106/233 Gene Ontology BP GO:0010822 0.000234741299096092 0.000330574416652458 4155 3483.36363636364 3331 2.13423954430459e-05 1179 1.35015417154466 -0.768073953095382 -1 4.36237419555485 3954 4404 3278 4152 3162 1179 3057 4613 3034 4153 3331 3605 M15291 GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of macrophage differentiation. 12/25 Gene Ontology BP GO:0045649 5.30742216685482e-05 8.10071042758282e-05 3615 3153.27272727273 3331 4.82504564623777e-06 1438 1.76254745717659 1.17111310253088 1 6.69406694189988 3613 1863 1438 2596 2936 4606 4047 3373 3331 2811 4072 3606 M16160 GO_PROTEIN_INSERTION_INTO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_INSERTION_INTO_MEMBRANE.html The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. 11/30 Gene Ontology BP GO:0051205 0.0034835278005596 0.00435019353899898 4305 3138.54545454545 3331 0.000317186904800947 748 2.98122280426484 2.98122280426484 1 6.53506535980365 4304 2960 2398 2524 3512 3405 4216 2797 748 3331 4329 3607 M10441 GO_DENDRITIC_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_MIGRATION.html The movement of a dendritic cell within or between different tissues and organs of the body. 7/48 Gene Ontology BP GO:0036336 0.0765897756730953 0.0843068583333764 2615 3382.54545454545 3332 0.00793650793650794 2062 2.31268756327117 2.31268756327117 1 2.30592821625172 2612 4641 3585 4277 4077 3150 2062 2963 3794 2715 3332 3608 M12989 GO_ORGANELLE_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_FUSION.html The joining of two lipid bilayers to form a single organelle membrane. 51/104 Gene Ontology BP GO:0090174 1.35416622592596e-05 2.29299554594247e-05 3335 3104.81818181818 3332 1.23106778299869e-06 1539 1.10699628492539 -0.982834297457795 -1 4.76755296192864 2584 3469 3204 4449 2650 1539 3332 3332 3983 3707 1904 3609 M13819 GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that activates or increases the frequency, rate or extent of chromatin modification. 48/111 Gene Ontology BP GO:1903310 1.89723639651487e-07 5.42084220862679e-07 3715 3230.09090909091 3333 1.724760509208e-08 1551 1.40285062879203 -1.16326168917096 -1 8.15955220793083 3713 3861 2600 2808 1551 3715 3721 3175 2506 3333 4548 3610 M14552 GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER.html The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. 50/91 Gene Ontology BP GO:0006890 0.0854769909343702 0.0907545549755958 2665 3345.27272727273 3333 0.00809006613190691 1968 0.938547726026955 -0.979646482230078 -1 0.907920784717293 2664 4161 3333 3759 4008 1968 3018 3052 4183 4167 2485 3611 M15081 GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION.html Any process that activates or increases the frequency, rate or extent of dendrite extension. 7/29 Gene Ontology BP GO:1903861 0.00238933056747656 0.00302197271173894 3890 3258.63636363636 3333 0.000239190346700409 1042 1.98009482053631 -1.03162437208451 -1 4.63132840498922 3886 3099 4345 2854 3475 3060 3628 3333 1042 2747 4376 3612 M16547 GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION.html Any process that modulates the frequency, rate or extent of sister chromatid segregation. 40/81 Gene Ontology BP GO:0033045 0.13563136735937 0.142732647019391 2880 3551.18181818182 3335 0.013163138332811 2472 1.11126815529248 -1.11185121685158 -1 0.872146703071842 2876 4333 3335 4422 4561 2472 3096 2622 4184 4162 3000 3613 M10325 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. 9/25 Gene Ontology BP GO:0061339 9.27488200522967e-06 1.61346111466022e-05 3610 3058.45454545455 3336 9.27492071600334e-07 1440 1.55513256411646 -1.87647128895133 -1 6.91791530020528 3608 3756 3566 3472 2597 2328 3822 1440 3336 3060 2658 3614 M10506 GO_ICOSANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. 22/58 Gene Ontology BP GO:0046456 0.0839184282471183 0.0891201423493528 2275 3299.90909090909 3336 0.00793650793650794 1846 1.66853784143612 1.54831729539395 1 1.62631409985762 2275 3891 2266 4532 4398 3223 1846 3911 3765 3336 2856 3615 M11547 GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 342/771 Gene Ontology BP GO:0010638 6.63210604422521e-09 5.4988891267693e-08 3570 2950.54545454545 3336 6.02918733110755e-10 324 1.58917367630799 -1.169635797663 -1 10.7092897418439 3566 4213 2415 2259 324 1863 3985 3336 2368 3498 4629 3616 M14959 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 50/103 Gene Ontology BP GO:0043620 4.73121476675963e-05 7.28833117520404e-05 2445 3151.18181818182 3337 4.30119683369527e-06 1832 1.28260222376292 1.39564388035528 1 4.92590093533925 2443 3687 2757 3550 2906 4263 3337 1832 2853 3408 3627 3617 M16398 GO_APOPTOTIC_MITOCHONDRIAL_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_MITOCHONDRIAL_CHANGES.html The morphological and physiological alterations undergone by mitochondria during apoptosis. 46/85 Gene Ontology BP GO:0008637 1.22547933528276e-07 3.8465050004516e-07 4180 3355 3337 1.11407218504217e-08 1399 1.51303299952637 1.54809252473218 1 9.00968702080134 4178 2586 2660 3532 1399 2773 4630 4636 3337 2880 4294 3618 M16799 GO_RESPONSE_TO_LEPTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEPTIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. 11/27 Gene Ontology BP GO:0044321 1.60272277192624e-05 2.67389214159307e-05 3445 3230.54545454545 3338 1.45703131640601e-06 2296 1.38549527274256 -0.957390129245147 -1 5.88114262949166 3444 2399 2296 2495 2698 4503 3338 3602 3648 3332 3781 3619 M12877 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS.html The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. 68/130 Gene Ontology BP GO:0090501 0.0129902634080604 0.0154255225073209 2155 3166.72727272727 3340 0.00118796424409366 1359 0.959381421248173 -0.903107122334694 -1 1.61347071141107 2153 4362 3340 4600 3807 1359 2854 2092 3886 4174 2207 3620 M15813 GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of fatty acid derivative. 22/58 Gene Ontology BP GO:1901570 0.0839184282471183 0.0891201423493528 2280 3301.18181818182 3340 0.00793650793650794 1847 1.66853784143612 1.54831729539395 1 1.62631409985762 2276 3892 2267 4533 4399 3224 1847 3912 3766 3340 2857 3621 M11188 GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 8/17 Gene Ontology BP GO:0009129 0.0116672345544126 0.013911394462285 2225 3175.90909090909 3341 0.00117289470168217 1846 0.718311802721535 -0.718311802721535 -1 1.23796190662144 2223 3326 3704 3714 3660 1846 2226 3341 4158 4351 2386 3622 M12284 GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. 8/25 Gene Ontology BP GO:1901798 0.0765897756730953 0.0843068583333764 3785 3347.09090909091 3341 0.00793650793650794 2743 1.24934848858854 1.50063959160498 1 1.24569689426688 2913 2743 3883 3632 3928 3784 2983 2909 3341 2918 3784 3623 M14803 GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 20/51 Gene Ontology BP GO:0046685 0.000881498138343336 0.00116537467435311 4005 3365.72727272727 3341 8.01683214663428e-05 2169 1.15150853268016 -1.01157555118046 -1 3.13564915091653 4005 2514 2702 4323 3341 2677 4615 4025 3797 2169 2855 3624 M10566 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. 17/40 Gene Ontology BP GO:0051154 1.1012190521267e-05 1.89790648070685e-05 4225 3309.54545454545 3343 1.00111324032964e-06 1380 1.81522613202925 -1.81861170373662 -1 7.9561062317641 4221 3343 1867 4014 2606 4331 3926 3292 3058 1380 4367 3625 M14603 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE.html The directed movement of a protein to a specific location in a vacuole. 28/44 Gene Ontology BP GO:0072666 0.00184804367185637 0.00236885297312323 4275 2912.54545454545 3343 0.000168145263031 891 0.838632892714667 -0.838632892714667 -1 2.04383913374196 2011 3635 3343 4275 3844 891 1920 2075 4271 4146 1627 3626 M11304 GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 33/82 Gene Ontology BP GO:0033143 5.58598700133281e-08 2.13105020665705e-07 3820 3124.18181818182 3344 5.07817013015068e-09 1118 1.0012412596051 -1.01370519102011 -1 6.20047924059342 3818 2651 3066 3597 1118 2050 3789 4177 3880 3344 2876 3627 M11444 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. 123/266 Gene Ontology BP GO:0048002 5.1825821715342e-05 7.93102472723576e-05 3200 3271.54545454545 3344 4.71154932967495e-06 1849 1.36279494837432 -1.21603139855897 -1 5.187457300723 3198 3766 2949 4111 2926 1849 3419 3791 3344 3877 2757 3628 M12193 GO_SEXUAL_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEXUAL_REPRODUCTION.html A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. 320/1219 Gene Ontology BP GO:0019953 6.29761054407085e-08 2.30162001994041e-07 3395 3082.90909090909 3344 5.72510065849375e-09 1173 1.56244960000611 -1.38782002070157 -1 9.62742620219356 3395 4117 2311 3344 1173 2122 3636 3937 2610 3231 4036 3629 M12044 GO_HISTONE_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_EXCHANGE.html The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. 33/164 Gene Ontology BP GO:0043486 0.0678139022272514 0.0758333208191542 2215 3220.45454545455 3345 0.00636355793845332 2147 2.15022223639226 -1.74802329678563 -1 2.23575766621529 2212 4336 2147 3730 3842 2633 3427 3066 3400 3345 3287 3630 M12929 GO_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BINDING.html Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 64/163 Gene Ontology BP GO:0051101 6.94061397388626e-09 5.61415865518361e-08 4145 3247.27272727273 3345 6.30964908707516e-10 346 1.20826594330978 -0.928773866325221 -1 8.13228367921894 4143 2814 2709 3116 346 3301 3929 4538 3345 3347 4132 3631 M13261 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of B cell mediated immunity. 19/54 Gene Ontology BP GO:0002712 4.89656343040173e-05 7.53055449067745e-05 3990 3300.81818181818 3345 4.45152037921048e-06 2182 1.32507244939159 -1.25987497708414 -1 5.07154532415991 3986 2182 2590 3345 2913 4438 2223 4209 3513 2558 4352 3632 M13529 GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN.html The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. 7/25 Gene Ontology BP GO:0032490 0.00788262046780677 0.00952355108821932 2990 3409.09090909091 3345 0.000791072192871081 1829 1.78505299685981 1.78505299685981 1 3.34911262854388 2989 3855 4092 3227 4543 3805 3266 1829 3816 2733 3345 3633 M14890 GO_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTHENED_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. 34/88 Gene Ontology BP GO:0007224 0.00016153201307759 0.000232124152497446 3110 3438.36363636364 3346 1.46858067786942e-05 2955 1.21382629353629 -1.00574116753187 -1 4.09490665200178 3346 3265 3108 3471 3106 4381 2955 3139 3383 3716 3952 3634 M16453 GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the N-terminal amino acid residue in a protein. 10/27 Gene Ontology BP GO:0031365 0.192529129984 0.201195757487219 2950 3583.36363636364 3347 0.0192530016255737 2269 0.598482039778564 -0.598482039778564 -1 0.386871788935177 2946 4388 3309 4354 4013 2269 3083 3347 4245 4626 2837 3635 M16454 GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 72/204 Gene Ontology BP GO:0032479 0.000601509810384027 0.000810214693824497 3095 2952.27272727273 3347 5.46976667542262e-05 708 1.12134778505044 -1.172522840179 -1 3.21784136870254 3091 4122 3356 4559 3319 708 3347 1472 3672 3696 1133 3636 M14320 GO_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 13/38 Gene Ontology BP GO:0070741 7.54599720818971e-08 2.62836196831394e-07 3950 2714.72727272727 3348 6.85999769728846e-09 733 2.51979640588519 -2.25216257739681 -1 15.3915111377574 3948 3348 1053 1846 1246 4411 3526 3835 733 1296 4620 3637 M15765 GO_VESICLE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING.html The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. 25/63 Gene Ontology BP GO:0048278 0.000932752919229494 0.00123033289885868 3890 3314 3348 8.48316928548081e-05 2373 0.759489253932158 -0.566985525707767 -1 2.05154167209013 3890 2621 3161 3103 3348 2373 3574 2993 3997 4019 3375 3638 M11533 GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. 9/36 Gene Ontology BP GO:1903306 0.000863455742241487 0.00114347547382408 2870 3285.63636363636 3350 8.637914259449e-05 2158 1.44550811681129 -1.80563639203496 -1 3.94728817588864 4623 2158 3763 2869 3350 3840 2869 3423 3140 2338 3769 3639 M11705 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 93/207 Gene Ontology BP GO:1903828 7.38881739862172e-08 2.5901401979669e-07 4015 3231.81818181818 3350 6.71710695161735e-09 1235 1.10677663715728 -0.802913658937807 -1 6.76698885439676 4015 3230 2998 3652 1235 2701 4104 1980 3350 3925 4360 3640 M12847 GO_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_VACUOLE.html A process in which a protein is transported to, or maintained at, a location in a vacuole. 35/61 Gene Ontology BP GO:0072665 0.0115434831093952 0.0137815356330475 2975 3280.36363636364 3350 0.00105495462748516 1325 0.838632892714667 -0.838632892714667 -1 1.44849796122441 2971 3658 3350 4220 3831 1325 3278 3192 4065 4186 2008 3641 M13470 GO_PROTEIN_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MONOUBIQUITINATION.html Addition of a single ubiquitin group to a protein. 31/65 Gene Ontology BP GO:0006513 0.129550041750316 0.13648759787763 3025 3576.36363636364 3350 0.0125339697178881 2132 0.768732642529285 -0.813125990715697 -1 0.617182549317443 3024 4566 3262 3995 4216 2132 3350 3288 4500 4171 2836 3642 M11293 GO_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 305/702 Gene Ontology BP GO:0030163 6.76621855940216e-06 1.21342420901136e-05 2850 3099 3351 6.15112669941961e-07 179 1.3348793392184 -1.05145563874774 -1 6.09146699127556 2846 4319 3351 4465 3553 179 2777 4510 2860 4195 1034 3643 M15483 GO_CELL_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_RECOGNITION.html Cell recognition between cells. May involve the formation of specialized cell junctions. 42/135 Gene Ontology BP GO:0009988 1.88767385706086e-07 5.39684095956501e-07 4400 3375.63636363636 3351 1.71606729002694e-08 1550 1.61354938813305 -1.16768178426993 -1 9.38794873936651 4400 3920 2235 3189 1550 3008 4388 4153 3351 3263 3675 3644 M12250 GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 140/301 Gene Ontology BP GO:0010821 1.57803162586553e-07 4.71480105462911e-07 3915 3239.63636363636 3352 1.43457430823246e-08 769 1.22414791545497 -0.785656560519594 -1 7.18900944297484 3915 4187 3352 4370 1481 769 3013 4590 3082 4131 2746 3645 M14986 GO_HISTONE_H3_K4_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_TRIMETHYLATION.html The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. 7/18 Gene Ontology BP GO:0080182 0.000880399222689857 0.00116458506864644 3415 2708.45454545455 3352 8.80748213554141e-05 1300 1.43473722650267 -1.43473722650267 -1 3.90729544796437 2255 3413 4331 3709 3352 1300 1498 1352 3415 3574 1594 3646 M16113 GO_MIDGUT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDGUT_DEVELOPMENT.html The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. 9/25 Gene Ontology BP GO:0007494 5.91032172277622e-05 8.96785090158497e-05 4420 3401.18181818182 3352 5.91047892222345e-06 2381 2.65950947509166 -2.65950947509166 -1 9.99165245423001 4418 3352 4511 2924 2961 4044 3459 2899 2381 3094 3370 3647 M15752 GO_HETEROCHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. 3/13 Gene Ontology BP GO:0070828 0.0246996606611208 0.0286123379710469 3325 3429 3353 0.00249785665849704 2126 0.489576708065163 -0.489576708065163 -1 0.701425236576455 3322 3682 4452 3353 4301 2521 2614 2126 4262 4590 2496 3648 M12754 GO_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. 17/50 Gene Ontology BP GO:0009112 0.00182183205737048 0.00233667575756109 4130 3449.90909090909 3358 0.000165758407079524 2436 1.27236453860583 -1.10079437389634 -1 3.10790543587808 4130 2785 2436 2674 3425 3269 4320 4200 3131 3358 4221 3649 M14807 GO_CARDIOLIPIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOLIPIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. 6/15 Gene Ontology BP GO:0032048 0.00715995608781158 0.00867981099626871 3375 3067.45454545455 3358 0.000718313048158205 203 2.78207372425659 -0.593167781461455 -1 5.32376572654918 3373 3358 4296 3035 3615 4597 2802 2046 203 3450 2967 3650 M15649 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING.html The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. 15/29 Gene Ontology BP GO:0000717 0.00575345672905407 0.00703722328582668 2495 3192.72727272727 3358 0.000524414412176996 1126 0.399155863276969 -0.399155863276969 -1 0.79758065485167 2493 4383 3358 3927 3855 1126 2267 2722 4504 4582 1903 3651 M10299 GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION.html The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 8/22 Gene Ontology BP GO:0086069 0.000958956320679074 0.00126417779582991 3515 2869.45454545455 3359 9.59370390933443e-05 1081 2.31387958571276 1.9328642674588 1 6.22496640799125 3513 3459 3563 2212 3359 3619 2653 1450 1081 2123 4532 3652 M11260 GO_TELOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. 63/120 Gene Ontology BP GO:0032200 0.0141549702998196 0.0167571461249521 945 2947 3359 0.00129517030762974 941 1.07647063185301 -1.07647063185301 -1 1.77445633158723 941 4365 3359 3935 3981 1384 2150 2021 3959 4149 2173 3653 M12390 GO_REGULATION_OF_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEEDING_BEHAVIOR.html Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. 4/30 Gene Ontology BP GO:0060259 0.00121752077054923 0.00159058777086665 3340 3265.36363636364 3359 0.000121818834594378 2078 1.90586187844316 -1.40823202626166 -1 4.95081745973026 3340 2164 3901 3211 3386 3359 4186 3816 2792 2078 3686 3654 M14806 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. 37/110 Gene Ontology BP GO:0008543 0.0839184282471183 0.0891201423493528 2655 3361.54545454545 3359 0.00793650793650794 2302 1.40213342823299 1.51589828071244 1 1.36665123995053 2654 4222 2462 3329 4024 3643 2302 4175 3359 3265 3542 3655 M11477 GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 7/20 Gene Ontology BP GO:0010763 0.000973229190208648 0.00128190159720248 3510 3407 3360 9.73655681887912e-05 2719 1.13040594716164 1.28121925692477 1 3.0347551451597 3509 3327 3754 2949 3360 4302 3331 2743 3546 2719 3937 3656 M15048 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSMEMBRANE_TRANSPORT.html The directed movement of a protein across a membrane by means of some agent such as a transporter or pore. 35/79 Gene Ontology BP GO:0071806 0.000176923709391701 0.000253067400710311 2140 3014.81818181818 3361 1.60852671977424e-05 519 0.773228660846146 -0.713161825701692 -1 2.58160010110244 2138 4075 3361 4459 4540 519 1771 2671 4295 4187 1147 3657 M14880 GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that stops or reduces the activity of a monooxygenase. 5/24 Gene Ontology BP GO:0032769 2.21760157895832e-05 3.61909459792741e-05 3955 3564.36363636364 3362 2.21762370917457e-06 2294 1.09694168176795 -0.943034844990117 -1 4.5224373209425 3953 2294 4309 2374 2770 4426 3320 4543 3362 3289 4568 3658 M15194 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 17/29 Gene Ontology BP GO:1902253 1.14419255626474e-06 2.50234858160019e-06 4060 3196.27272727273 3362 1.04017559213223e-07 1778 1.11792623674053 -0.907669777504504 -1 5.81297447158081 4059 2186 2501 1778 2048 3924 4201 3941 2834 3362 4325 3659 M15254 GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN.html The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 30/58 Gene Ontology BP GO:0051220 1.84997057898491e-05 3.06108816757909e-05 3365 3189.54545454545 3362 1.68180557771948e-06 943 1.00592355994559 -0.737740838896471 -1 4.2150972731061 3362 4100 3144 3015 2718 943 4224 3718 3964 4083 1814 3660 M16191 GO_PEPTIDYL_LYSINE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_METHYLATION.html The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. 38/84 Gene Ontology BP GO:0018022 1.11166842984234e-05 1.91307506291994e-05 1655 2739.63636363636 3362 1.01061277016841e-06 216 0.976199413224413 -0.976199413224413 -1 4.27553305328029 1654 4496 3362 4558 4572 216 958 1587 4070 4201 462 3661 M13872 GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 113/242 Gene Ontology BP GO:0061136 1.06750227218075e-05 1.84458989569603e-05 2255 2712.81818181818 3363 9.70461320035567e-07 221 1.08275245683658 -1.12034845121902 -1 4.75812388042734 2252 4068 3363 4149 4285 221 1509 1802 3670 4125 397 3662 M14820 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. 15/39 Gene Ontology BP GO:0006360 0.0339560050107964 0.0389278348802784 2715 3295.81818181818 3364 0.00313561024978655 1656 0.509301442945895 -0.509301442945895 -1 0.666473462985456 2714 3895 3364 3610 4291 1656 2534 2887 4252 4537 2514 3663 M12682 GO_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 51/115 Gene Ontology BP GO:0051983 0.211815485399819 0.220754051338128 3070 3590.27272727273 3365 0.021406028117592 2313 0.964552481905287 -0.960525470695846 -1 0.587434088474843 3070 4440 3365 4157 4531 2313 3104 3058 4302 4214 2939 3664 M13062 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. 23/35 Gene Ontology BP GO:0000462 0.016694487198565 0.0196632430398116 2220 3223.45454545455 3366 0.00152932128392395 1436 0.528782813678074 -0.528782813678074 -1 0.837554689684516 2220 4577 3366 4293 4371 1436 2211 1994 4535 4446 2009 3665 M14667 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 5/14 Gene Ontology BP GO:0032740 0.0190887765626908 0.0223022620987855 2730 3156.81818181818 3367 0.0019254758382384 1732 0.828779327635385 -0.828779327635385 -1 1.27065101969571 2729 3678 4269 3367 3962 1732 1894 2195 4360 4529 2010 3666 M10227 GO_POSITIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA replication. 39/115 Gene Ontology BP GO:0045740 0.0839184282471183 0.0891201423493528 4530 3482.63636363636 3368 0.00793650793650794 2294 1.68329565068444 1.86444409638421 1 1.64069845223867 4529 3689 2294 3018 4152 2703 4609 3054 3368 3101 3792 3667 M13443 GO_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAPPING.html The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. 20/43 Gene Ontology BP GO:0036260 0.00171884873482181 0.00221192202765457 1470 2965.45454545455 3369 0.000156381193935199 881 0.67972840396511 -0.67972840396511 -1 1.6753543762613 1470 4292 3369 4216 4438 881 1548 2004 4181 4469 1752 3668 M11044 GO_MALE_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DETERMINATION.html The specification of male sex of an individual organism. 2/17 Gene Ontology BP GO:0030238 0.13411491204602 0.141232827541318 3160 3397.8 3369.5 0.0158730158730159 2578 1.0605218207371 -1.0605218207371 -1 0.836836176069306 3234 3505 3674 NA 4155 3156 3611 2800 4108 2578 3157 3669 M14394 GO_7_METHYLGUANOSINE_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_7_METHYLGUANOSINE_RNA_CAPPING.html The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. 20/43 Gene Ontology BP GO:0009452 0.00171884873482181 0.00221192202765457 1475 2987 3370 0.000156381193935199 882 0.67972840396511 -0.67972840396511 -1 1.6753543762613 1471 4293 3370 4217 4439 882 1549 2183 4182 4518 1753 3670 M11470 GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 15/27 Gene Ontology BP GO:0009067 3.36399806204914e-05 5.32527889604301e-05 4590 3293 3371 3.05822681973567e-06 1705 1.51473234593772 -1.31883648715258 -1 6.00903530249965 4589 3371 2351 1902 2833 3779 4640 3971 1705 3174 3908 3671 M11945 GO_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_FORMATION.html The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 8/26 Gene Ontology BP GO:0003272 0.000101369526590994 0.000149036957556043 3345 3348.81818181818 3372 1.01374150989301e-05 1751 1.362649829172 1.09002388354129 1 4.84036921430455 3342 3492 3831 2819 3045 3372 1751 4197 3736 2915 4337 3672 M13101 GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 7/19 Gene Ontology BP GO:0060192 0.000189152771527067 0.000269811464884845 4325 3607 3372 1.89168873903052e-05 2729 1.99078478544544 -2.37273008564036 -1 6.5952709166416 4325 2900 4013 3571 3145 4627 3372 3334 3310 2729 4351 3673 M13926 GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. 73/188 Gene Ontology BP GO:0050852 0.000688356491131861 0.000920253149532172 2465 2864 3372 6.25974513559449e-05 726 1.18826485152387 -1.00531324233312 -1 3.34886308846763 2465 3508 3372 3378 4076 726 2412 3018 3460 3961 1128 3674 M12048 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION.html The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. 15/30 Gene Ontology BP GO:0000715 0.0802109238620287 0.0882301159657425 4495 3386 3373 0.0075721764564281 1946 0.411521427841144 -0.411521427841144 -1 0.402772520749544 2339 4131 3373 3613 4492 1946 2270 3298 4493 4393 2898 3675 M10397 GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 85/214 Gene Ontology BP GO:0046488 4.93274542993173e-07 1.20098253965249e-06 4085 3336.18181818182 3374 4.48431503266459e-08 1834 1.49433143625136 -1.28111359350376 -1 8.21243146134193 4084 3048 2771 3802 1834 3079 4126 4217 2600 3374 3763 3676 M12046 GO_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). 83/171 Gene Ontology BP GO:0045333 0.00918077063882121 0.0110488123577104 1410 2887.54545454545 3375 0.00083811891300183 1241 0.957002063880566 -0.658645731655661 -1 1.73821201943898 1407 3599 3436 3375 3672 1241 1707 3711 3013 4228 2374 3677 M15696 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. 12/30 Gene Ontology BP GO:0015012 0.000872731467581802 0.00115477121800579 3165 3518.63636363636 3375 7.93707153789197e-05 2279 1.02001807886264 0.594286450672625 1 2.7813487864573 3164 3375 2902 4326 3339 3283 2279 4568 3745 3907 3817 3678 M10069 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. 58/140 Gene Ontology BP GO:1903214 0.00122465476666988 0.00159810907297589 3580 3285.54545454545 3376 0.000111394274207848 888 1.39301365568749 -0.774556906783581 -1 3.61595309600955 3577 4218 3176 4062 3376 888 2706 4000 3101 4066 2971 3679 M13046 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 19/36 Gene Ontology BP GO:0006294 0.0170323428355932 0.0200357658438458 2955 3326.27272727273 3376 0.00156051399789487 1598 0.535677302295585 -0.419665135273175 -1 0.844422113133688 2954 4295 3376 3553 3684 1598 2660 3302 4256 4445 2466 3680 M12563 GO_RNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. 61/121 Gene Ontology BP GO:0009451 0.00554607788922051 0.00679072775307248 1345 2999.18181818182 3378 0.000505464435304574 1114 0.955617364773687 -0.92760095531437 -1 1.92322089811498 1341 4098 3378 4495 4235 1114 2790 1717 3976 4133 1714 3681 M11438 GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. 39/164 Gene Ontology BP GO:0030518 0.00137637025556921 0.00178704896437579 4240 3294.27272727273 3379 0.000125202918109212 2037 1.59742969117521 -1.37333609981624 -1 4.07460989747457 4237 3863 2439 2677 3392 2381 4534 4316 2037 3379 2982 3682 M13990 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. 51/106 Gene Ontology BP GO:0042590 0.0090756814953106 0.0109308402549227 1710 3073.90909090909 3379 0.000828485378411221 1238 0.94680879008359 -0.754736363860093 -1 1.72379527671214 1707 3813 3379 4153 4009 1238 1859 3346 3952 4120 2237 3683 M11866 GO_AMINO_ACID_BETAINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_TRANSPORT.html The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/40 Gene Ontology BP GO:0015838 0.000518079268113383 0.000703345626272057 3385 3432.63636363636 3381 5.18200090516757e-05 1967 1.08874123191088 0.972617417385893 1 3.18635753654975 3381 1967 3818 2747 3274 4350 4191 4455 3582 3072 2922 3684 M16514 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 23/77 Gene Ontology BP GO:1903556 0.0212090795304995 0.0246863264628 2060 3281.90909090909 3381 0.0019469407601645 2057 1.80485195842416 -1.08378733202869 -1 2.69322995868456 2777 3955 2060 3596 4602 4155 2749 2057 3551 3381 3218 3685 M12830 GO_LYMPHANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHANGIOGENESIS.html Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. 4/15 Gene Ontology BP GO:0001946 0.0100152105587404 0.0120125607399203 3635 3289.72727272727 3382 0.00100606359555873 1258 2.11532840688171 -2.11532840688171 -1 3.77077455211278 3632 3382 3966 2605 3943 3338 4638 4502 1258 3114 1809 3686 M13660 GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. 38/88 Gene Ontology BP GO:1901222 1.35521532253951e-06 2.89966117168247e-06 3385 3199 3382 1.23201468851119e-07 2078 1.49926725343636 -1.0287371733202 -1 7.7067967364972 3382 3951 2078 2412 2103 4493 3898 3411 3110 2623 3728 3687 M14934 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. 22/45 Gene Ontology BP GO:0006383 0.014174809730549 0.0167763552329695 4100 3188.72727272727 3382 0.00129699743571299 1385 0.747173925644887 -0.747173925644887 -1 1.23129783255264 2382 4448 3382 4360 3903 1385 2692 2083 4099 4099 2243 3688 M12894 GO_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXIT_FROM_MITOSIS.html The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. 10/16 Gene Ontology BP GO:0010458 0.0266497170269287 0.0307874187997089 3385 3311.90909090909 3383 0.00245255651372667 1657 1.62369615523127 -0.565513175721606 -1 2.27833942779857 3383 4016 2514 2905 3727 4550 2781 4276 1657 3805 2817 3689 M15653 GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE.html The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. 22/47 Gene Ontology BP GO:0042769 0.10000144314488 0.105885222467886 2325 3459.09090909091 3383 0.00953264795145672 2018 0.426255103106889 -0.426255103106889 -1 0.38584817658486 2321 4382 3383 3931 4465 2018 2689 2939 4458 4583 2881 3690 M10225 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. 9/34 Gene Ontology BP GO:2000678 8.00339038834379e-06 1.41722889294738e-05 4640 3290.45454545455 3384 8.00341921290586e-07 1697 1.17957429262121 -1.07463082251262 -1 5.30893244573273 4636 1697 3556 2787 2561 3950 3924 3384 2994 2332 4374 3691 M11237 GO_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_TRANSPORT.html The directed movement of substances into, out of or within a vacuole. 156/316 Gene Ontology BP GO:0007034 0.000114175538324005 0.000166703466804514 1815 2847.09090909091 3385 1.03801331121324e-05 470 1.03472156175944 -0.996819623410449 -1 3.62878247337621 1814 3385 3392 4340 3743 470 2224 2387 3783 4150 1630 3692 M16031 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. 29/70 Gene Ontology BP GO:0042273 0.216286368964914 0.225009547637037 2435 3415.72727272727 3385 0.0219119665670134 2320 1.03059946385729 -1.03059946385729 -1 0.619725291837013 2434 4414 3385 3688 3997 2320 3070 2838 4359 4157 2911 3693 M10813 GO_COENZYME_A_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 7/17 Gene Ontology BP GO:0015936 0.000169442771617389 0.000243040713197262 3390 3323.09090909091 3386 1.69455692887824e-05 1837 0.812652204913889 -0.985659998425621 -1 2.72646888114245 3386 3592 3642 4191 3127 1837 2673 2767 4025 4331 2983 3694 M15860 GO_REGULATION_OF_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PERMEABILITY.html Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. 56/113 Gene Ontology BP GO:0090559 0.000247163532091006 0.000347435749166982 3205 3450.27272727273 3386 2.24719367777728e-05 2199 1.42193619241752 -0.99391334841498 -1 4.565785975728 3202 4192 3045 4065 3169 3806 2935 2199 3386 3876 4078 3695 M10980 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 8/24 Gene Ontology BP GO:0071276 0.0765897756730953 0.0843068583333764 3185 3371 3388 0.00793650793650794 1896 1.63468004753288 -2.02520344436302 -1 1.62990226945632 3217 3853 3665 3421 4149 3184 1896 3184 3388 2906 4218 3696 M14621 GO_DNA_GEOMETRIC_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_GEOMETRIC_CHANGE.html The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. 46/101 Gene Ontology BP GO:0032392 0.135118052563848 0.142224692372239 3390 3469.09090909091 3389 0.0131098759908224 1974 0.642356228754269 -0.642356228754269 -1 0.505057859521521 1974 4558 3389 3940 4227 2145 2813 3386 4541 4236 2951 3697 M14646 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that stops, prevents, or reduces the rate of leukocyte degranulation. 7/18 Gene Ontology BP GO:0043301 2.61928941685994e-05 4.22709793621157e-05 3590 3106.18181818182 3389 2.61932029041882e-06 978 1.62922413074363 -2.35313255751147 -1 6.61491915028422 3587 2113 4265 3389 2799 3827 978 3734 2893 1974 4609 3698 M14750 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. 17/30 Gene Ontology BP GO:1904376 0.0013717421858013 0.00178153817305607 3790 3415.18181818182 3390 0.000124781658247671 2646 0.889785450970719 -0.939668600767934 -1 2.27070913794034 3787 2921 2646 4090 3390 2706 3755 3132 4239 3779 3122 3699 M10766 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. 9/21 Gene Ontology BP GO:0043302 1.84594010446304e-08 9.93160681924959e-08 3395 2863.54545454545 3391 1.84594011979677e-09 759 1.2742839203264 -0.693413523133805 -1 8.28358342509008 3391 980 3630 1674 759 4279 3369 4080 1752 3738 3847 3700 M16531 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. 17/30 Gene Ontology BP GO:1903077 0.0013717421858013 0.00178153817305607 3790 3414.36363636364 3391 0.000124781658247671 2647 0.889785450970719 -0.939668600767934 -1 2.27070913794034 3788 2922 2647 4091 3391 2707 3756 3112 4240 3781 3123 3701 M12516 GO_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_PROLIFERATION.html The expansion of a leukocyte population by cell division. 38/127 Gene Ontology BP GO:0070661 5.35065475396614e-07 1.28854201362369e-06 3915 3251.54545454545 3392 4.86423277755251e-08 1853 1.61567387036747 1.52219942264076 1 8.83346025525678 3913 3392 2423 3239 1853 3652 4391 3620 2088 3342 3854 3702 M16638 GO_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. 37/88 Gene Ontology BP GO:0055072 1.2764688125158e-06 2.75145993338481e-06 3900 3327.72727272727 3393 1.16042686649121e-07 2085 1.44685268923679 -1.24907050218703 -1 7.4679664068382 3900 3393 2755 4548 2085 2760 3558 4013 3044 2948 3601 3703 M12380 GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. 61/149 Gene Ontology BP GO:0002220 0.000195808322865884 0.000278791181559736 1810 2754 3394 1.78023411562978e-05 528 0.915952343504234 -0.873528369433002 -1 3.02236914537844 1809 4005 3394 3686 4095 528 1613 2059 3899 4132 1074 3704 M15461 GO_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECOMBINATIONAL_REPAIR.html A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. 48/92 Gene Ontology BP GO:0000725 0.261160840785762 0.270481771975974 4240 3450.90909090909 3395 0.0271407973738983 1772 0.654445886263536 -0.711671982395133 -1 0.344973260308998 1772 4495 3395 3938 4240 2430 2803 3068 4514 4240 3065 3705 M16703 GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 9/13 Gene Ontology BP GO:0007260 0.00131355177358689 0.00171026945730901 3640 3380.63636363636 3396 0.000131432885835198 2489 2.0390980231845 2.6889778548893 1 5.2372856070242 3636 3130 4607 2489 3396 4625 3434 2659 2608 3096 3507 3706 M13599 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate, or extent of mast cell activation. 8/21 Gene Ontology BP GO:0033005 9.07116122290439e-08 3.0300288890608e-07 3400 2855.09090909091 3397 9.07116159319124e-09 757 1.26983972214709 1.47884518174531 1 7.68367974623794 3397 870 4101 1702 1333 4384 3862 4588 757 2925 3487 3707 M14124 GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. 18/30 Gene Ontology BP GO:0032469 0.00206203094078684 0.00262805645294353 2705 3240.54545454545 3397 0.000187633290460997 2142 1.09542320683563 0.86095666412137 1 2.62380913955141 2703 2142 2737 2531 3439 3989 2801 4267 3798 3842 3397 3708 M15602 GO_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINESIS.html The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. 48/118 Gene Ontology BP GO:0000910 0.00146457509586758 0.0018973276144289 4455 3571.90909090909 3397 0.000133231908775971 2273 1.59865819974539 -0.921414572992169 -1 4.03915158268871 4452 4330 2273 4198 3397 2678 4217 3372 2947 3334 4093 3709 M16950 GO_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MITOCHONDRION.html The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. 32/69 Gene Ontology BP GO:0006626 0.00664940164244436 0.00807775296333573 1905 3170.36363636364 3397 0.000606325874220507 1567 0.738616803909627 -0.627020817069114 -1 1.43481925517961 1905 4334 3397 4468 4383 1567 2354 1762 4247 4177 2280 3710 M15121 GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 22/55 Gene Ontology BP GO:0002756 0.00146941983152424 0.00190307288082762 2820 3211.90909090909 3398 0.000133672927487026 2311 1.02938007508638 -1.04924045907437 -1 2.59956518884064 2817 3550 3133 3424 3398 2311 3482 3125 3937 3710 2444 3711 M10659 GO_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 67/162 Gene Ontology BP GO:0042157 4.53761444987716e-08 1.84299195461185e-07 4020 3337.81818181818 3399 4.12510413042528e-09 1040 1.29015969992821 -0.860323118832869 -1 8.06522428035298 4017 3141 2892 4313 1040 2694 4259 3399 2764 3850 4347 3712 M12694 GO_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACETYLATION.html The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic 76/148 Gene Ontology BP GO:0006473 0.00133493251937783 0.00173567395336636 2485 3115.63636363636 3399 0.000121431202594436 839 1.05542955180683 -0.932148322505901 -1 2.70452576094261 2483 4406 3399 4471 4099 839 2605 2644 3711 4135 1480 3713 M12794 GO_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. 146/316 Gene Ontology BP GO:0019882 3.27090731839092e-06 6.27814083476191e-06 3400 3265.18181818182 3399 2.97355652864338e-07 1781 1.34087562628815 -1.17873621660354 -1 6.47503435964663 3399 3683 2956 4098 2342 1781 3703 4024 3274 3786 2871 3714 M16084 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. 17/42 Gene Ontology BP GO:0032733 0.00148514458411268 0.0019218300735884 3110 3174.27272727273 3399 0.000135104372986948 2107 1.68857584618174 1.88903203928899 1 4.25760171269655 3110 3931 2246 3595 3399 3417 2107 3744 3555 2836 2977 3715 M16676 GO_STABILIZATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_STABILIZATION_OF_MEMBRANE_POTENTIAL.html The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 5/16 Gene Ontology BP GO:0030322 0.000771370065501363 0.00102679793982879 3980 3405.63636363636 3399 7.71637951682307e-05 1942 1.60376068687831 -0.999783121227577 -1 4.44901763662578 3978 2497 4603 1942 3333 3399 4330 2867 3660 2294 4559 3716 M11322 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_ELONGATION.html Any process that modulates the frequency, rate, extent or accuracy of translational elongation. 16/25 Gene Ontology BP GO:0006448 0.161385165508919 0.168954075187804 2290 3433 3401 0.0158730158730159 2287 0.518865275719251 -0.518865275719251 -1 0.371938322347466 2287 4046 3381 3838 4123 2403 2645 3401 4176 4361 3102 3717 M12427 GO_LEYDIG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEYDIG_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. 3/13 Gene Ontology BP GO:0033327 0.0473292900302681 0.0535975350269597 2985 3502 3401 0.00483686102796368 2332 0.918968267115215 0.918968267115215 1 1.08409075332715 2985 3735 3906 3401 3897 3365 3008 2332 4124 4415 3354 3718 M16609 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_SNRNP_ASSEMBLY.html The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. 23/45 Gene Ontology BP GO:0000387 0.108136733813427 0.1143427135267 2270 3507.72727272727 3401 0.0103499258942202 2270 0.660495531342779 -0.660495531342779 -1 0.577422418767682 2270 4167 3401 4227 3885 2393 3039 3023 4461 4632 3087 3719 M11275 GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper cell differentiation. 9/40 Gene Ontology BP GO:0045622 3.9602687070678e-05 6.193171979426e-05 3870 3447.18181818182 3403 3.96033928561508e-06 2335 1.8055666853777 1.738663540917 1 7.0528940238824 3870 2988 3720 3403 2888 4389 3295 2977 3507 2335 4547 3720 M13221 GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. 21/44 Gene Ontology BP GO:0070911 0.018219770195932 0.0213352819721847 2795 3347.27272727273 3404 0.00167022128396952 1474 0.476708104577645 -0.476708104577645 -1 0.739388065386519 2794 4418 3404 3848 4079 1474 2769 2789 4450 4452 2343 3721 M16716 GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. 34/88 Gene Ontology BP GO:0009185 0.00122971881412816 0.0016042664945201 3260 3410.63636363636 3404 0.000111855156358647 2167 1.30988578079716 -0.980025772275302 -1 3.39814094906921 3257 4041 2749 3962 3377 2167 3998 3886 3404 3718 2958 3722 M13466 GO_BASIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASIC_AMINO_ACID_TRANSPORT.html The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/14 Gene Ontology BP GO:0015802 7.83666795294952e-06 1.3930187329841e-05 3405 3142.90909090909 3405 7.83669558910076e-07 1730 1.94080105316912 -1.53089058484225 -1 8.74848152313688 3405 3538 4080 3701 2550 2655 3592 4318 2220 1730 2783 3723 M11768 GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 68/154 Gene Ontology BP GO:0042177 0.00246264045813928 0.00311130330534441 3065 3239.18181818182 3407 0.000224127401943389 945 1.43166517546499 -1.17232310557075 -1 3.33176911027675 3740 4490 3010 4232 4172 945 3061 3064 3407 4095 1415 3724 M15044 GO_RESPONSE_TO_THYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_THYROID_HORMONE.html A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 16/42 Gene Ontology BP GO:0097066 4.09314145232886e-07 1.02949381165563e-06 4075 3163.63636363636 3408 3.72103837624157e-08 1382 2.12233279881504 -2.46356578465938 -1 11.7955764986784 4075 2729 1382 3076 1772 4434 3487 4196 3408 1687 4554 3725 M10052 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 6/19 Gene Ontology BP GO:0071402 4.26754323436412e-05 6.62018150255683e-05 1465 2782.18181818182 3409 4.26762519024287e-06 287 1.69143747178447 1.69143747178447 1 6.56161837427956 1465 4179 3526 3592 4436 1447 287 2580 4016 3409 1667 3726 M10864 GO_MATURATION_OF_SSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. 29/44 Gene Ontology BP GO:0030490 0.0292872865515336 0.0337505265472252 1960 3318.27272727273 3410 0.00269859959361547 1611 0.528782813678074 -0.528782813678074 -1 0.722389425031932 1956 4568 3410 4297 4640 1611 2574 2325 4527 4335 2258 3727 M13847 GO_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). 115/553 Gene Ontology BP GO:0002250 2.00720840219787e-07 5.66188858530056e-07 4470 3150 3410 1.82473507757187e-08 1327 1.64092101059303 -1.25144334574202 -1 9.51548663966738 4468 3767 1327 4252 1575 2610 4540 3410 3070 1767 3864 3728 M16244 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI.html The directed movement of a protein to a specific location in the Golgi apparatus. 9/19 Gene Ontology BP GO:0072600 0.00521012413884113 0.00639624705886816 2455 3309.18181818182 3410 0.000522238002661074 1144 0.706313349368641 -0.706313349368641 -1 1.43852667189229 2451 3410 4534 4178 4575 1144 2650 2773 4441 4610 1635 3729 M16669 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN.html The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. 5/23 Gene Ontology BP GO:0006123 0.000664943980955547 0.000890748673853608 3550 3412.45454545455 3410 6.65143032511491e-05 1642 0.465848462768493 -0.437522549679858 -1 1.31901106705466 3547 1642 4601 2328 3314 2929 3641 4089 3402 4634 3410 3730 M16827 GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 9/22 Gene Ontology BP GO:0071371 0.000251343995099014 0.000353098387063456 3190 3635.18181818182 3411 2.51372427836913e-05 2756 3.01085351443874 -3.57235249104043 -1 9.64811928208123 4236 3190 4622 3635 3188 4544 3411 2756 3115 3097 4193 3731 M10692 GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER.html The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 6/16 Gene Ontology BP GO:0090557 0.0518964964982441 0.0584985271282708 2535 3271.54545454545 3412 0.00531498539476364 2502 1.4850608061708 1.4850608061708 1 1.69951636715384 2532 3359 3619 2722 3819 3669 2579 4125 3649 3412 2502 3732 M13737 GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. 2/18 Gene Ontology BP GO:0021892 0.211067395279364 0.220023780036391 3110 3618.6 3412 0.0259976842942006 2796 0.409063847287827 -0.409063847287827 -1 0.249675373694559 3108 3567 4125 NA 4639 2796 3257 2876 4462 4487 2869 3733 M15332 GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 149/352 Gene Ontology BP GO:0010498 3.13020518193767e-05 4.98235949939547e-05 1555 2834.18181818182 3412 2.84568156366094e-06 307 1.14920420023633 -0.796787062790529 -1 4.58979999897384 1555 4066 3412 3991 4370 307 1529 3429 3017 4239 1261 3734 M15269 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html A process in which a protein is transported to, or maintained in, a location within the mitochondrion. 44/92 Gene Ontology BP GO:0070585 0.037813087712135 0.0431366501836469 2325 3239.18181818182 3413 0.0034980993148229 1690 0.854004846450057 -0.627020817069114 -1 1.08220842142759 2322 4220 3413 4067 3763 1690 2524 2688 4073 4126 2745 3735 M15977 GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. 53/146 Gene Ontology BP GO:0031098 9.07296904486767e-07 2.04394930981662e-06 4505 3398.72727272727 3413 8.24815707875633e-08 1995 1.19762209136234 -1.04925230460714 -1 6.32506960551012 4504 2998 2856 3413 1995 3532 3329 4482 3610 3011 3656 3736 M10642 GO_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION.html A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 63/129 Gene Ontology BP GO:0006261 0.383094674262073 0.393693796502613 1285 3464.72727272727 3414 0.0429624976470394 1281 0.78133005595899 -0.78133005595899 -1 0.293621815843273 1281 4494 3414 3856 4297 2607 3079 3271 4498 4246 3069 3737 M16153 GO_GLYCEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROL_TRANSPORT.html The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. 7/11 Gene Ontology BP GO:0015793 0.000240518373605645 0.000338299548212968 4025 3073.81818181818 3414 2.40544409661379e-05 1102 3.17665017885021 -2.73855951176499 -1 10.2342359118129 4024 1102 4519 2068 3182 3554 4177 3414 2246 1983 3543 3738 M14625 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION.html A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. 26/47 Gene Ontology BP GO:0033683 0.00679751380516922 0.00825120433918973 2510 3296.54545454545 3415 0.000619873447619344 1698 0.554904359272267 -0.472701998249631 -1 1.07319115876681 2510 4262 3415 4064 3605 1698 2767 2719 4222 4527 2473 3739 M10085 GO_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. 27/70 Gene Ontology BP GO:0002181 0.0181293016738478 0.021245418392649 2485 3271.54545454545 3416 0.00166185858692457 1471 0.889365271887003 -0.889365271887003 -1 1.38094478536218 2482 4501 3416 3764 4589 1471 1841 3248 4486 4134 2055 3740 M10780 GO_PROTEIN_N_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. 40/81 Gene Ontology BP GO:0006487 0.0016977544243588 0.0021859882951464 3310 3566.63636363636 3416 0.000154460546347372 3078 0.943587460812197 1.25289333498679 1 2.33018496638254 3306 3203 3269 4319 3416 4085 3160 3078 3488 4103 3806 3741 M11437 GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. 12/44 Gene Ontology BP GO:0045920 0.00158963845498706 0.00205247256576888 4615 3396.18181818182 3416 0.00014461711200748 2170 1.44550811681129 -1.80563639203496 -1 3.60640172270692 4615 2829 2170 3111 3408 3747 3562 3416 4134 2794 3572 3742 M14372 GO_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that modulates the frequency, rate or extent of the transcription of the viral genome. 34/86 Gene Ontology BP GO:0046782 0.00400181734705071 0.00496537625397019 2010 3178.09090909091 3416 0.000364465025101973 968 1.08230751360794 0.905618887387018 1 2.31478824982149 2009 3976 3261 3416 4273 2767 968 4388 3744 3927 2230 3743 M16423 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 5/33 Gene Ontology BP GO:0090208 0.0156040036672827 0.0184349590399984 3430 3447.18181818182 3417 0.00157146670985759 2208 2.96294571455731 2.96294571455731 1 4.77014435488763 3428 3381 4563 2822 3686 4502 3786 2208 2833 3293 3417 3744 M11357 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. 17/69 Gene Ontology BP GO:0002716 0.0839184282471183 0.0891201423493528 4065 3536.63636363636 3418 0.00793650793650794 2320 1.79706662191865 -0.927869007381074 -1 1.75159036806649 4062 3607 2320 3059 4045 3418 4469 3394 3023 3354 4152 3745 M12161 GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 2/10 Gene Ontology BP GO:0046133 0.00410186557959086 0.00508543708572506 3825 3251.1 3419 0.000456595873502324 2078 1.2461129267615 -1.2461129267615 -1 2.6531253486273 3825 2078 3860 NA 3564 3578 3440 3398 3232 2582 2954 3746 M14535 GO_PIRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. 5/15 Gene Ontology BP GO:0034587 0.00251254820792943 0.00317176762626872 3420 3348.27272727273 3419 0.000251539354102051 1192 2.27290818428332 -1.44426871454093 -1 5.27187249582777 3419 3710 4249 3256 3481 4485 4237 3190 1192 2282 3330 3747 M15795 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY.html Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. 17/69 Gene Ontology BP GO:0045953 0.0839184282471183 0.0891201423493528 4065 3538.18181818182 3419 0.00793650793650794 2321 1.79706662191865 -0.927869007381074 -1 1.75159036806649 4063 3608 2321 3060 4046 3419 4470 3391 3024 3365 4153 3748 M10252 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS.html The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. 38/67 Gene Ontology BP GO:0097031 0.00106696133603611 0.00139822226452601 890 2780.09090909091 3420 9.70435586496824e-05 796 0.734228844655145 -0.734228844655145 -1 1.94544514908471 890 4037 3420 3755 4481 796 1107 1956 4397 4198 1544 3749 M10915 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. 192/441 Gene Ontology BP GO:0090316 2.87895660264027e-08 1.33669955060588e-07 2965 3110.81818181818 3420 2.61723330937707e-09 885 1.55678866616376 2.02989089925421 1 9.93358898863563 2965 4250 2549 3992 885 3512 3420 2338 2556 3775 3977 3750 M13411 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. 38/67 Gene Ontology BP GO:0032981 0.00106696133603611 0.00139822226452601 895 2771.27272727273 3421 9.70435586496824e-05 797 0.734228844655145 -0.734228844655145 -1 1.94544514908471 891 4038 3421 3756 4482 797 1108 1849 4398 4199 1545 3751 M15064 GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. 38/67 Gene Ontology BP GO:0010257 0.00106696133603611 0.00139822226452601 895 2794.09090909091 3422 9.70435586496824e-05 798 0.734228844655145 -0.734228844655145 -1 1.94544514908471 892 4039 3422 3757 4483 798 1109 2090 4399 4200 1546 3752 M10934 GO_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLATION.html The modification of histones by addition of methyl groups. 42/94 Gene Ontology BP GO:0016571 6.08157099704917e-05 9.20362911971946e-05 4225 2725.36363636364 3424 5.52885374499193e-06 390 0.81605768028263 -0.806065522778757 -1 3.05735259419944 1547 4221 3424 4611 4135 390 951 1627 3970 4222 881 3753 M11307 GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 16/29 Gene Ontology BP GO:0071480 0.00512786191532542 0.00630025479567503 3990 3492.72727272727 3424 0.000467259392899427 2948 0.959816537202623 -0.660431941334687 -1 1.96067991678186 3988 3184 2971 3586 3566 2948 3395 4201 3903 3254 3424 3754 M14500 GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. 35/83 Gene Ontology BP GO:1901292 3.30621220527552e-07 8.60950267475841e-07 3935 3119.72727272727 3424 3.00564791103731e-08 1591 1.4517777614679 -0.824268607243504 -1 8.17337917275201 3933 3424 2325 3624 1712 3452 4457 1591 2129 3143 4527 3755 M15586 GO_PROTEIN_ACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACYLATION.html The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. 94/188 Gene Ontology BP GO:0043543 4.89240696756936e-05 7.52665525196307e-05 2095 2966.18181818182 3425 4.44774160849761e-06 362 1.03755325566822 -0.958482909052213 -1 3.97131897473723 2092 4484 3425 4593 3979 362 2256 2672 3753 4185 827 3756 M16777 GO_RESPONSE_TO_WATER_DEPRIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER_DEPRIVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. 4/17 Gene Ontology BP GO:0009414 0.00594650399463353 0.00725804890827641 3425 3271.36363636364 3425 0.000596247659162204 1503 2.2959962416554 -0.766114650273052 -1 4.55918953880035 3425 3168 4618 3330 3700 3863 3975 1760 1503 3129 3514 3757 M11026 GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 6/16 Gene Ontology BP GO:0009070 3.1691759953958e-05 5.03952061928537e-05 3430 3403.18181818182 3427 3.16922119284719e-06 1933 1.0171713455431 -1.21857637285511 -1 4.05779700647581 3427 1933 3671 2777 2843 3903 4062 4258 3097 3415 4049 3758 M16236 GO_SNRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. 42/91 Gene Ontology BP GO:0016073 0.0159193945280997 0.018774129741927 4605 3272.36363636364 3428 0.00145779721208231 1422 0.729732841083087 -0.71345896598495 -1 1.16945763761858 2274 4441 3428 4604 4601 1422 2457 2241 4095 4223 2210 3759 M12223 GO_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 40/79 Gene Ontology BP GO:0032204 0.0408282509581042 0.0464735398868541 3305 3578.54545454545 3430 0.00378238581067826 1714 0.6550589108292 -0.596665475893467 -1 0.810424386464532 3304 4564 3374 4076 4437 1714 2976 3430 4510 4400 2579 3760 M12689 GO_RESPONSE_TO_INACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. 12/23 Gene Ontology BP GO:0014854 0.0482293276271393 0.0545502480323527 3965 3427.36363636364 3430 0.00448366039113235 2309 1.57643932781586 -1.15527659338633 -1 1.84850060267674 3965 3430 2468 2830 3967 4260 4596 2309 2935 2800 4141 3761 M13747 GO_MRNA_CLEAVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE.html Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. 13/22 Gene Ontology BP GO:0006379 0.00187802958306702 0.00240476871323226 3180 3514 3430 0.000170875880114636 3032 0.921240295939841 -0.873568957087286 -1 2.23957375798731 3606 4076 3141 4187 3430 3032 3176 3180 3945 3516 3365 3762 M12983 GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. 6/20 Gene Ontology BP GO:0014821 8.04762971192656e-05 0.000119952310601846 4505 3441.54545454545 3431 8.04792116632952e-06 2056 1.62210661943902 -0.884542148485253 -1 5.9039736640947 4502 2076 3989 2056 3015 3961 4202 3342 3236 3431 4047 3763 M11842 GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. 11/54 Gene Ontology BP GO:0021522 0.0839184282471183 0.0891201423493528 3400 3405.81818181818 3433 0.00793650793650794 2059 1.70531993076902 1.05503165108901 1 1.66216539223939 3400 3777 2469 3525 4173 3433 2059 4634 3105 2655 4234 3764 M10596 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. 17/29 Gene Ontology BP GO:1902108 6.89358914562191e-05 0.000103348189871238 4460 3644.36363636364 3434 6.26709560203688e-06 2852 1.56170872040353 -1.26649015398701 -1 5.7779456947594 4458 3580 2852 3348 2974 3434 4476 4430 3036 3351 4149 3765 M12917 GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. 8/17 Gene Ontology BP GO:0006044 0.0765897756730953 0.0843068583333764 1985 3265.18181818182 3434 0.00793650793650794 1985 1.03319983961527 1.06385387546774 1 1.03017996904284 1985 2599 3980 3504 3975 3180 2753 3434 3223 3648 3636 3766 M13161 GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 9/21 Gene Ontology BP GO:0002183 0.148292549054458 0.155527965949819 2670 3355.36363636364 3434 0.0159230835444718 2227 1.05956456957549 -1.05956456957549 -1 0.794896786396728 2669 4311 4026 3434 4239 2316 2227 2818 4440 3749 2680 3767 M10585 GO_FOREBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 5/20 Gene Ontology BP GO:0048853 0.0359125537024759 0.0410694548868462 3435 3351 3435 0.00365064777906725 2502 1.74666645914289 -1.74666645914289 -1 2.24798301367919 3435 3881 3609 3815 3769 2780 2975 2502 3923 3268 2904 3768 M12251 GO_POLYAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. 8/17 Gene Ontology BP GO:0006595 0.000136295308170765 0.000196894559999023 2175 3258.90909090909 3435 1.36303668277384e-05 1566 0.677333721224165 0.619194481773884 1 2.32996730770942 2172 3435 3878 3783 3093 2256 1566 4519 4084 4406 2656 3769 M13628 GO_DNA_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION.html The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. 16/31 Gene Ontology BP GO:0022616 0.635038432341642 0.646030552445715 2575 3664 3435 0.0875600650982913 2574 0.399650916192813 -0.399650916192813 -1 0.0703920290907868 2574 4231 3312 3988 4340 2912 3075 3415 4540 4482 3435 3770 M15338 GO_GOLGI_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LOCALIZATION.html Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. 9/19 Gene Ontology BP GO:0051645 0.0296656342572869 0.0341441596074822 3440 3450.72727272727 3436 0.00300692610784999 2147 1.07704823006263 -1.07704823006263 -1 1.46636018777078 3436 3778 4391 3292 3988 2941 3886 3076 3266 3757 2147 3771 M11714 GO_PROTEIN_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLATION.html The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 60/135 Gene Ontology BP GO:0006479 3.00845867824167e-06 5.8249681580801e-06 1310 2659 3437 2.73496617478207e-07 142 0.919544343848225 -0.922593576669905 -1 4.46821571657655 1308 4325 3437 4612 4634 142 916 1362 4023 4211 279 3772 M12167 GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 83/200 Gene Ontology BP GO:0002221 1.02673580949274e-05 1.77811800204208e-05 4300 3394.90909090909 3437 9.33400546618652e-07 2371 1.57121939372896 -1.46700107886026 -1 6.92792495082332 4297 3200 2371 4028 2598 3437 3727 4134 3090 2822 3640 3773 M16145 GO_PROTEIN_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALKYLATION.html The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 60/135 Gene Ontology BP GO:0008213 3.00845867824167e-06 5.8249681580801e-06 1310 2660.18181818182 3438 2.73496617478207e-07 143 0.919544343848225 -0.922593576669905 -1 4.46821571657655 1309 4326 3438 4613 4635 143 917 1365 4024 4212 280 3774 M14423 GO_I_KAPPAB_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_PHOSPHORYLATION.html The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 20/54 Gene Ontology BP GO:0007252 6.64681193483178e-07 1.55471777397602e-06 4005 3442.63636363636 3439 6.04255813001762e-08 1910 1.1767120842434 -1.27102247930409 -1 6.3444211330825 4004 3007 2819 3307 1910 4171 3439 4457 3244 3604 3907 3775 M12288 GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING.html Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. 5/11 Gene Ontology BP GO:0006346 0.0102790287077199 0.0123194450929126 3120 3383 3440 0.0010326886855923 2206 0.597763298437309 -0.506548232228639 -1 1.05949091571022 3117 2206 3884 2892 3643 3327 2784 3746 3440 4410 3764 3776 M15919 GO_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION.html The process in which a methyl group is covalently attached to a molecule. 137/308 Gene Ontology BP GO:0032259 0.000172402810099563 0.000246905073193174 4610 2949.45454545455 3442 1.56742110830282e-05 514 1.03848412948137 -0.931930223650973 -1 3.47753658136627 1585 4610 3442 4608 4440 514 2030 1871 3950 4259 1135 3777 M11099 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. 51/89 Gene Ontology BP GO:0033108 0.000322797105426894 0.000448995494456881 540 2582 3443 2.93494979884062e-05 539 0.730853203449894 -0.730853203449894 -1 2.27118921322102 539 3573 3443 3678 4165 606 985 1550 4336 4213 1314 3778 M14006 GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. 6/15 Gene Ontology BP GO:0033004 0.0133281593548287 0.015814629155244 2140 3268.09090909091 3443 0.00134087786373194 1309 0.905315703975791 0.905315703975791 1 1.51345188957129 2137 4025 4169 4443 4395 2460 1309 2422 4269 3443 2877 3779 M16613 GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. 10/21 Gene Ontology BP GO:0034616 7.86755598389583e-05 0.000117381306019371 4025 3382.18181818182 3443 7.15257941319604e-06 2154 1.08774165859109 1.18783809864298 1 3.96854902842259 4023 2401 2154 2606 2990 4187 3801 3903 3443 3221 4475 3780 M11482 GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. 42/77 Gene Ontology BP GO:0072384 0.00561782475364697 0.00687495000821899 3410 3116.36363636364 3444 0.000512020152982704 1116 1.08100750484439 -1.03845788125672 -1 2.17020223540606 3407 3444 3058 3665 4044 1116 4347 2273 3654 3584 1688 3781 M10781 GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. 46/97 Gene Ontology BP GO:0031145 0.0686909441090274 0.0767770952090068 1560 3324.36363636364 3445 0.00644858131289651 1558 0.635877667611427 -0.635877667611427 -1 0.6580019788339 1558 4073 3445 3766 4327 1893 2956 3053 4476 4235 2786 3782 M13150 GO_TETRAHYDROFOLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. 9/20 Gene Ontology BP GO:0046653 0.0765897756730953 0.0843068583333764 3185 3546.18181818182 3445 0.00793650793650794 2911 1.37690660224797 -0.557211901599992 -1 1.37288220203467 3181 3353 4023 2976 3902 4480 3640 3445 2911 3748 3349 3783 M15179 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 13/18 Gene Ontology BP GO:0045717 2.16146151396838e-05 3.53492983774398e-05 4580 3372.36363636364 3445 1.96498431840157e-06 1692 0.959210503429916 -0.80330062102116 -1 3.96370251861689 4577 1692 2826 2578 2745 3445 4170 4624 3493 2967 3979 3784 M13410 GO_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 26/73 Gene Ontology BP GO:0042116 1.9444027524646e-06 3.95265410669577e-06 4465 3350.27272727273 3446 1.76764042815242e-07 2202 1.54875739981881 -1.64545830228347 -1 7.76777129219259 4461 2916 2355 4027 2202 3523 4446 3446 3134 2381 3962 3785 M14029 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION.html The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. 48/108 Gene Ontology BP GO:0006369 0.0645953620425208 0.0723038249670742 2105 3337 3446 0.00605216373858812 1862 0.806855095242404 -0.776893969756326 -1 0.854454300617191 2104 4258 3446 4472 4132 1862 2575 2623 4361 4155 2719 3786 M11047 GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. 87/342 Gene Ontology BP GO:0050851 0.00552078405395508 0.00676154058626047 3700 3261.18181818182 3448 0.000503153367227032 1125 1.29502622905458 -1.03484332881276 -1 2.60854461227893 3700 3544 3326 3440 4174 1125 3448 4275 3301 3911 1629 3787 M13743 GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 253/528 Gene Ontology BP GO:0042176 8.65641984092337e-06 1.5172426319897e-05 2970 3124.18181818182 3448 7.86950354712755e-07 199 1.14290619288861 -0.975426018858674 -1 5.11248064850133 2968 4429 3448 4519 4104 199 2774 3051 3559 4244 1071 3788 M14606 GO_APOPTOTIC_DNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_DNA_FRAGMENTATION.html The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. 6/18 Gene Ontology BP GO:0006309 0.0765897756730953 0.0843068583333764 2610 3306.45454545455 3448 0.00793650793650794 2114 1.20871230768181 -1.20871230768181 -1 1.20517947811152 2610 4246 4256 4034 4253 2315 2114 2521 3881 3448 2693 3789 M15177 GO_INTRACELLULAR_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIPID_TRANSPORT.html The directed movement of lipids within cells. 16/57 Gene Ontology BP GO:0032365 0.0839184282471183 0.0891201423493528 4560 3341.09090909091 3448 0.00793650793650794 2187 1.11714907104583 1.12394434907404 1 1.08887861476667 4558 2187 2374 2339 4475 2612 3582 3448 3974 2701 4502 3790 M10886 GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 91/209 Gene Ontology BP GO:0031330 3.0844127717224e-08 1.39444289183127e-07 4470 3234.27272727273 3449 2.80401164996913e-09 914 1.26895165635226 -1.1294526619706 -1 8.07531797012551 4467 4090 3002 4541 914 1770 4451 3605 3449 3390 1898 3791 M12638 GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0034030 0.00196280943479853 0.00250641479806644 3200 3258.27272727273 3449 0.000196454527242367 1294 0.552338190204965 -0.465031969007773 -1 1.33353881171946 3199 2802 3943 4103 3449 1294 2154 3606 4217 4425 2649 3792 M10239 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of mRNA metabolic process. 72/183 Gene Ontology BP GO:1903311 0.00219884321222328 0.00279245870742688 2125 3259.54545454545 3450 0.000200094907211467 923 0.95379920957812 -0.878523865780091 -1 2.26125325815722 2124 4552 3450 4564 4284 923 2247 3056 4400 4243 2012 3793 M13640 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0034033 0.00196280943479853 0.00250641479806644 3200 3279.27272727273 3450 0.000196454527242367 1295 0.552338190204965 -0.465031969007773 -1 1.33353881171946 3200 2803 4110 4104 3450 1295 2155 3604 4218 4483 2650 3794 M10847 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. 8/15 Gene Ontology BP GO:0043923 0.0127185417873377 0.0151105909720084 3455 3144.81818181818 3451 0.00127919261854317 1850 1.52279908873774 -1.88477020510974 -1 2.57367991359875 3451 2742 3647 1850 3669 3933 2165 4225 2091 2905 3915 3795 M14655 GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. 8/19 Gene Ontology BP GO:0006646 0.00165579401512925 0.00213432859862441 4565 3631.90909090909 3451 0.000165702905469362 2797 1.39998601456279 -1.44791763418247 -1 3.4707570633989 4561 2797 4267 3451 3424 4095 3867 3092 3060 2932 4405 3796 M14952 GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0033866 0.00196280943479853 0.00250641479806644 3205 3304.54545454545 3451 0.000196454527242367 1296 0.552338190204965 -0.465031969007773 -1 1.33353881171946 3201 2804 4324 4105 3451 1296 2156 3603 4219 4540 2651 3797 M16937 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. 114/261 Gene Ontology BP GO:1903322 0.000578648494558899 0.000781007255882839 2010 3064 3451 5.26182498123134e-05 701 0.907894929435605 -0.811388575533258 -1 2.61875074512308 2006 4189 3451 4160 4367 701 2609 2357 4081 4163 1620 3798 M13298 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING.html Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. 14/30 Gene Ontology BP GO:0006297 0.583078720037967 0.594213015174776 2485 3574 3452 0.0764520253889844 2484 0.736801864681223 -0.736801864681223 -1 0.154610455408474 2484 4304 3252 3551 4320 2906 3363 3452 4456 3970 3256 3799 M13663 GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. 61/139 Gene Ontology BP GO:0051351 0.0327411277799813 0.03759076564848 1645 3304.72727272727 3452 0.00302170840512106 1641 0.756014111609746 -0.733357929482724 -1 0.999974858138966 1642 4124 3452 4074 4425 1641 2773 3035 4346 4215 2625 3800 M10174 GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST.html Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. 6/28 Gene Ontology BP GO:0044144 0.0466944760828804 0.0529044539904377 4575 3326.72727272727 3453 0.00477056801818692 1823 1.27564511426573 -1.43534934081592 -1 1.51154963986782 4574 1823 3549 3146 3798 4212 3412 2529 3453 2519 3579 3801 M10410 GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. 62/127 Gene Ontology BP GO:2000058 0.00247774071670016 0.00312867831048106 1185 3042.27272727273 3453 0.000225503242695143 938 0.810063121910833 -0.810063121910833 -1 1.88335899546775 1183 4289 3453 3939 4617 938 2160 2496 4257 4220 1913 3802 M10749 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. 6/29 Gene Ontology BP GO:0051150 0.000139683504301899 0.000201601029056176 3690 3281.36363636364 3453 1.39692285245344e-05 2124 1.11971978418653 -0.950302688228747 -1 3.84107272739776 3690 2494 3628 3453 3098 3988 3056 2124 3929 2522 4113 3803 M12918 GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. 41/90 Gene Ontology BP GO:0006368 0.0398554488603991 0.0454107605052351 2340 3371.09090909091 3454 0.00369057590908129 1706 0.735350590779352 -0.673374800885106 -1 0.916617525946898 2340 4259 3454 4366 4389 1706 2520 3225 4082 4169 2572 3804 M14615 GO_MUSCLE_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_FATE_COMMITMENT.html The process in which the cellular identity of muscle cells is acquired and determined. 4/19 Gene Ontology BP GO:0042693 1.52286706326614e-08 8.78206701948561e-08 4605 2709.90909090909 3454 1.5228670737022e-09 684 2.58478228063507 -2.09642357510996 -1 16.9307616712633 4603 739 4258 953 684 4039 4610 3454 853 1237 4379 3805 M15352 GO_TROPHECTODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHECTODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. 6/14 Gene Ontology BP GO:0001829 0.000140258170205181 0.000202367521523509 4600 3555.27272727273 3454 1.40267023551074e-05 2698 0.888570136554009 -1.05871301605348 -1 3.04678046355472 4597 2806 4393 2698 3100 3464 4095 3001 3321 3454 4179 3806 M11511 GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 24/83 Gene Ontology BP GO:0048260 4.9600117257145e-05 7.62308323154334e-05 4575 3343.72727272727 3455 4.50920323202504e-06 1747 1.68127155458569 -1.4596594579292 -1 6.42657463900835 4573 2551 1862 3514 2915 3905 4486 4384 3455 1747 3389 3807 M13340 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 151/356 Gene Ontology BP GO:0090068 6.81645815416891e-09 5.53300965206403e-08 3555 3318.36363636364 3455 6.1967801593536e-10 339 1.57873329856902 1.65287397309666 1 10.6349960890566 3551 4607 2215 3072 339 3217 3455 4509 3032 3884 4621 3808 M13972 GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 10/26 Gene Ontology BP GO:0045073 0.000289587694853807 0.000404013121155716 4640 3393.45454545455 3455 2.63296200482979e-05 1872 1.65370121983592 -1.44078116502477 -1 5.20939636800327 4637 3455 1899 2956 3193 3832 4046 4257 3052 1872 4129 3809 M12321 GO_REGULATION_OF_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. 10/20 Gene Ontology BP GO:0090231 0.0115896859771883 0.0138331393295849 3595 3298.18181818182 3456 0.00105919954742033 2558 1.06609202799581 -1.2643069486722 -1 1.83976220693552 3592 3456 2828 2573 3645 2930 3834 3455 3607 3802 2558 3810 M11656 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL.html A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. 60/138 Gene Ontology BP GO:0070646 0.0010123531667883 0.00132928612935466 2655 3188.81818181818 3457 9.20744829171296e-05 787 0.819113351945771 -0.771653688897153 -1 2.18705446153125 2653 4409 3457 4516 4042 787 2146 2724 4379 4210 1754 3811 M16621 GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. 11/24 Gene Ontology BP GO:0043011 0.00675223621759771 0.00819838722759052 3260 3280.27272727273 3457 0.000615731787025831 1768 0.844134728771171 -0.949145762366922 -1 1.63475131970603 3260 3584 2848 3889 3604 2663 3457 1768 4206 3867 2937 3812 M12241 GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS.html The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. 134/275 Gene Ontology BP GO:0090305 0.00335487759883805 0.00419517820937383 2090 3165 3458 0.000305454959045987 982 1.00942927755724 -0.851932565009236 -1 2.2275106020895 2086 4611 3458 4602 3752 982 2570 2751 3713 4248 2042 3813 M10062 GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 25/50 Gene Ontology BP GO:0050856 3.94402184388632e-05 6.17192228552888e-05 3015 3086.90909090909 3459 3.58553868327983e-06 1149 1.78965892305189 -1.87647954601692 -1 6.9932349724843 3015 3888 1614 3792 2866 3708 2044 4311 3459 1149 4110 3814 M12055 GO_NUCLEAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSPORT.html The directed movement of substances into, out of, or within the nucleus. 218/481 Gene Ontology BP GO:0051169 0.019012256420668 0.0222184511857944 2995 3341.45454545455 3459 0.00174350680466433 1566 1.32855878305601 -1.3728961429736 -1 2.03890935813455 2995 4475 3459 4305 4081 1566 3418 2613 3630 4233 1981 3815 M11254 GO_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 72/165 Gene Ontology BP GO:0051340 0.00985519196506102 0.0118236837968419 1480 3144 3460 0.000899965316048096 1263 0.817134944266329 -0.812916237916704 -1 1.46184149971261 1477 4097 3460 3852 4588 1263 2514 2834 4092 4221 2186 3816 M12633 GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 7/15 Gene Ontology BP GO:0006244 0.000342631765862955 0.000475019196447209 1875 2637.27272727273 3461 3.42684605766721e-05 666 0.72954414711682 -0.72954414711682 -1 2.2505505366957 1874 3461 3942 4438 3728 666 905 1739 3723 3559 975 3817 M13579 GO_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR.html A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). 66/133 Gene Ontology BP GO:0006289 0.0839184282471183 0.0891201423493528 2775 3505.27272727273 3461 0.00793650793650794 2191 1.07390259469702 -0.582995645663693 -1 1.04672652128362 2775 4620 3461 3619 4349 2191 2954 4263 3048 4250 3028 3818 M14758 GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. 21/55 Gene Ontology BP GO:0060338 0.000452943920560498 0.000619557155757183 3165 3117.63636363636 3461 4.1185200106692e-05 1194 1.13934014602789 -1.18558814402961 -1 3.39270312966726 3162 3984 3104 4221 4198 1574 3461 1194 3898 3670 1828 3819 M13204 GO_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an mRNA molecule. 59/117 Gene Ontology BP GO:0031124 0.0226407479518968 0.0263197277768295 4325 3342.72727272727 3462 0.0020797420754625 1699 0.756025171993568 -0.784216100612575 -1 1.10862597947122 2388 4324 3462 4542 3712 1699 2688 2930 4322 4172 2531 3820 M14908 GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of cellular protein catabolic process. 168/354 Gene Ontology BP GO:1903362 4.58646474292171e-05 7.08650775420482e-05 2115 2942.27272727273 3463 4.16960032940327e-06 354 1.09925410267385 -1.03659479923255 -1 4.23418739052001 2111 4323 3463 4078 4596 354 1980 2498 3757 4238 967 3821 M10473 GO_REGULATION_OF_T_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. 5/13 Gene Ontology BP GO:0010819 0.000654451449205333 0.000877959571990859 4330 3370.72727272727 3464 6.54644267145166e-05 1492 1.80261847725038 -1.40724703130601 -1 5.11447386979831 4327 3464 3592 2829 3311 3621 4490 3377 2399 1492 4176 3822 M15974 GO_MACROMOLECULE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_METHYLATION.html The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. 102/226 Gene Ontology BP GO:0043414 4.11219685443159e-05 6.39843498496175e-05 4615 2870.36363636364 3464 3.7384306552911e-06 342 0.934706240308163 -0.858455619190125 -1 3.63885749465152 1602 4543 3464 4614 4615 342 1738 1486 4043 4255 872 3823 M12169 GO_LATERAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. 4/14 Gene Ontology BP GO:0048368 0.0207180623667375 0.0241329562390271 3520 3263.27272727273 3465 0.00209137927107825 2079 2.18052766606412 -2.18052766606412 -1 3.27374862507594 3519 3465 3864 2079 3713 3557 4337 3156 2723 3112 2371 3824 M10038 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION.html The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. 8/46 Gene Ontology BP GO:0050908 0.00221244270473633 0.00280675068403353 3850 3434.72727272727 3466 0.000221464850238259 963 1.320195225157 1.45899616704162 1 3.12718267696097 3846 2531 3522 3390 3466 4451 3321 4599 3278 963 4415 3825 M13163 GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY.html Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. 7/17 Gene Ontology BP GO:0006957 0.0352035884200068 0.040298387828918 2455 3272.54545454545 3467 0.00357740302744204 2011 1.60510167359752 -1.15214528075526 -1 2.07805140644974 2455 3414 4027 4089 4539 3514 2011 2234 3467 2730 3518 3826 M14779 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. 8/46 Gene Ontology BP GO:0050962 0.00221244270473633 0.00280675068403353 3850 3506.09090909091 3467 0.000221464850238259 970 1.320195225157 1.45899616704162 1 3.12718267696097 3847 2532 4291 3391 3467 4452 3322 4600 3279 970 4416 3827 M15816 GO_PYRUVATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRUVATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. 29/83 Gene Ontology BP GO:0006090 0.0839184282471183 0.0891201423493528 3735 3422.90909090909 3467 0.00793650793650794 2267 1.93910467511079 -1.53350483598345 -1 1.8900340472235 3732 4375 2356 3534 3923 2267 4506 3351 3287 3467 2854 3828 M11348 GO_RIBOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_ASSEMBLY.html The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. 36/75 Gene Ontology BP GO:0042255 0.0396997295155308 0.0452444389152208 2560 3217.09090909091 3468 0.00367588747544034 1705 0.833755291974807 -0.833755291974807 -1 1.0405127442763 2559 4369 3468 3617 4001 1705 2383 2723 4053 4194 2316 3829 M16840 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. 31/108 Gene Ontology BP GO:0046635 0.0032029121847748 0.00401271486074187 3145 3320.18181818182 3468 0.000291598612030673 2240 1.46804691120893 -1.07806094490015 -1 3.26586074888921 3142 3471 2402 4207 3500 2240 3468 4523 3686 2821 3062 3830 M10274 GO_NUCLEAR_ENVELOPE_REASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_REASSEMBLY.html The reformation of the nuclear envelope following its breakdown in the context of a normal process. 17/24 Gene Ontology BP GO:0031468 0.00258525916907626 0.00326178215272312 3665 3369.18181818182 3469 0.000235300196414105 1868 1.53671957337634 -0.639879210743106 -1 3.54699088034072 3661 4170 2685 2676 3469 3682 4119 4627 1868 3350 2754 3831 M11270 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. 23/62 Gene Ontology BP GO:0086004 0.00285877730147171 0.00359807617531394 3470 3378.90909090909 3469 0.000260227172300214 2360 1.65771139397603 -1.97242157505158 -1 3.76068312136454 3469 4166 2360 3673 3483 4206 2862 2717 3276 2458 4498 3832 M16023 GO_RNA_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_LOCALIZATION.html A process in which RNA is transported to, or maintained in, a specific location. 111/248 Gene Ontology BP GO:0006403 0.0643558511472901 0.0720878689690875 2245 3309.90909090909 3469 0.00602902998412169 1921 1.05593451398943 -1.1940455550268 -1 1.11950118712565 2243 4483 3469 3857 4100 1921 3210 2389 3992 4265 2480 3833 M16344 GO_FOLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 11/20 Gene Ontology BP GO:0046655 3.01878120181326e-05 4.82153461300962e-05 4455 3448.09090909091 3469 2.74438420501624e-06 2015 1.7038797417268 -1.37577567627251 -1 6.82765356173169 4455 3278 2015 3696 2812 3469 4459 4060 2769 2675 4241 3834 M12743 GO_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYUBIQUITINATION.html Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. 135/313 Gene Ontology BP GO:0000209 0.000106880355231993 0.000156692607938788 1900 3057 3470 9.7168680040388e-06 461 0.930241158280864 -0.808187573308323 -1 3.28559319628806 1898 4033 3470 4594 4456 461 2334 2999 3801 4249 1332 3835 M10095 GO_REGULATION_OF_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_BURST.html Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 6/20 Gene Ontology BP GO:0060263 0.000224799261824746 0.000317150705758826 3730 3305 3471 2.24822005681573e-05 2212 1.14464988324599 1.18796300646413 1 3.71751518877144 3729 2534 3531 3331 3170 3471 2212 4046 3699 2515 4117 3836 M10677 GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of dendritic cell differentiation. 18/50 Gene Ontology BP GO:2001198 0.0839184282471183 0.0891201423493528 2595 3458 3471 0.00793650793650794 2446 1.40663334608119 -1.13421074498127 -1 1.37103728417465 2591 3930 2693 4213 4043 2446 3345 4331 3897 3471 3078 3837 M12286 GO_PEPTIDYL_LYSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_MODIFICATION.html The modification of peptidyl-lysine. 179/381 Gene Ontology BP GO:0018205 0.00108579876053915 0.00142210540061588 2780 3280 3471 9.87577292312061e-05 800 1.15499376885518 -0.938469342079575 -1 3.05243642380315 2790 4606 3471 4565 4598 800 2776 2779 3813 4254 1628 3838 M10356 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. 95/205 Gene Ontology BP GO:1903321 0.000320103915052783 0.000445382822172631 4095 2848.54545454545 3472 2.91045909301694e-05 603 0.927693595876378 -0.911910597133869 -1 2.88590905059208 1417 4093 3472 3689 4369 603 1732 2443 4091 4218 1207 3839 M10912 GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. 18/42 Gene Ontology BP GO:0033006 8.62352516234406e-06 1.51376284796837e-05 3695 3277.45454545455 3472 7.83959905898812e-07 2054 1.00593103057803 1.19855596096139 1 4.50069055821352 3691 2054 2751 2518 2551 4034 3963 3784 2761 3472 4473 3840 M13717 GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 9/34 Gene Ontology BP GO:0002323 0.00963181723337182 0.0115616668600169 3715 3369.72727272727 3472 0.000967382104680454 1874 1.05447011277486 -0.690258987527879 -1 1.89595666097931 3712 3097 4121 2601 4063 4608 3472 1874 2214 3080 4225 3841 M12670 GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 70/262 Gene Ontology BP GO:0038095 0.000323055164723474 0.000449219865172534 1600 2867.81818181818 3473 2.93729648136975e-05 607 0.919352303837727 -0.891521772601057 -1 2.85678127726763 1597 4257 3473 3618 4488 607 2013 2333 3875 4142 1143 3842 M13892 GO_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BIOSYNTHETIC_PROCESS.html The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 63/137 Gene Ontology BP GO:0071897 0.0839184282471183 0.0891201423493528 2365 3553.36363636364 3473 0.00793650793650794 2361 1.00205699356053 -0.87326044620287 -1 0.976699024221778 2361 4364 3345 4068 4106 2544 3287 3473 4028 4184 3327 3843 M10199 GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. 48/104 Gene Ontology BP GO:0006354 0.0362814968482315 0.0414403419105385 2310 3330.63636363636 3474 0.00335400237946582 1674 0.722408340329307 -0.665062358143884 -1 0.927130828559631 2310 4329 3474 3760 4525 1674 2500 3234 4086 4196 2549 3844 M16225 GO_EPITHELIAL_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MATURATION.html The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 14/25 Gene Ontology BP GO:0002070 0.00271676326052899 0.00342211932138798 3475 3184.90909090909 3474 0.000247283998402444 1893 1.59207324292623 1.63153719591078 1 3.64395706404814 3474 3373 1893 2598 3478 4235 3719 4141 2162 1911 4050 3845 M10560 GO_REGULATION_OF_PROSTAGLANDIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROSTAGLANDIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. 10/18 Gene Ontology BP GO:0032306 0.00107262731548587 0.00140525074091447 2760 3544.63636363636 3475 9.75591491474989e-05 2759 1.0036036731902 -0.684431101129569 -1 2.65716398733521 2759 3851 2881 3368 3361 3611 3431 4057 4407 3790 3475 3846 M15413 GO_NUCLEAR_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXPORT.html The directed movement of substances out of the nucleus. 106/222 Gene Ontology BP GO:0051168 0.188977778228874 0.197573479918186 2755 3606.36363636364 3475 0.0188616524080078 2260 1.07203853572005 -1.12784368569321 -1 0.700840893677324 2752 4546 3475 4238 4292 2260 3311 3246 4270 4262 3018 3847 M12708 GO_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of mast cell degranulation. 18/42 Gene Ontology BP GO:0043304 8.62352516234406e-06 1.51376284796837e-05 3695 3281.18181818182 3476 7.83959905898812e-07 2055 1.00593103057803 1.19855596096139 1 4.50069055821352 3692 2055 2752 2519 2552 4035 3964 3812 2762 3476 4474 3848 M13357 GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS.html A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 11/28 Gene Ontology BP GO:0097067 2.0342152194273e-05 3.3409484484616e-05 3750 3350.90909090909 3476 1.84930366264104e-06 1166 2.43522523128141 -2.65649764450926 -1 10.1183799055742 3748 3158 1166 4312 2732 4412 3445 4506 3476 1449 4456 3849 M15016 GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 20/45 Gene Ontology BP GO:0002753 0.0062373875351489 0.00760109982301742 4250 3378.18181818182 3476 0.000568649285458098 2378 0.986305364209546 -0.910486346484541 -1 1.94015654182124 4249 3821 3106 3476 3590 2879 3593 3178 3724 3166 2378 3850 M15487 GO_RNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an RNA molecule. 70/144 Gene Ontology BP GO:0031123 0.0361592480682176 0.0413210408025435 2230 3343.72727272727 3476 0.00334250979939386 1673 0.713712039692027 -0.720750858722435 -1 0.916799604200161 2229 4288 3476 4561 3880 1673 2622 2982 4298 4216 2556 3851 M13854 GO_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_RECOMBINATION.html Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 112/230 Gene Ontology BP GO:0006310 0.228580031614711 0.237586095094494 1725 3519.63636363636 3477 0.0233168031642698 1725 0.822553461375575 -0.698704073051835 -1 0.476587042072978 1725 4545 3477 4163 4236 2348 3026 3359 4425 4278 3134 3852 M12198 GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 18/38 Gene Ontology BP GO:0044275 0.0727529446054446 0.0811609615096298 3365 3326.54545454545 3478 0.00684331696962042 1860 1.35818068399165 -0.771199068504717 -1 1.37503310016679 3364 3606 2730 3636 3907 4598 3145 2429 1860 3839 3478 3853 M12963 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. 43/66 Gene Ontology BP GO:0042274 0.0074855680776808 0.00906270993081407 4445 3201.63636363636 3478 0.000682832722360266 1191 0.497811766983944 -0.497811766983944 -1 0.943947211408775 1910 4442 3478 4075 4388 1191 2415 2397 4480 4441 2001 3854 M10557 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. 7/24 Gene Ontology BP GO:0032692 0.00472971922884709 0.00582959553478551 2010 3021.81818181818 3480 0.000473981609684095 1578 1.39314002112718 1.39314002112718 1 2.88946430907756 2007 3593 3602 3480 3570 2554 1578 2584 4351 3541 2380 3855 M13239 GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. 176/377 Gene Ontology BP GO:1903320 3.34324076970826e-05 5.29603101117552e-05 2000 2977.81818181818 3480 3.03935597864655e-06 316 0.990673937830149 -0.963580543706704 -1 3.93226320656602 1996 4032 3480 4303 4460 316 2439 2560 4007 4179 984 3856 M10862 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. 45/87 Gene Ontology BP GO:0006283 0.0783011067503569 0.0861497721900254 2325 3468.36363636364 3481 0.00738502197143643 1934 0.590750092130048 -0.493095521719126 -1 0.583873482352617 2324 4625 3481 4001 4311 1934 2770 3167 4370 4334 2835 3857 M13567 GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. 6/12 Gene Ontology BP GO:0008655 0.00416818324818436 0.00516159665137726 2195 2958.18181818182 3481 0.00041760221378121 1414 0.875704597020179 -0.875704597020179 -1 1.85923331368034 2191 2025 4098 3861 3547 1414 1710 3481 4000 4478 1735 3858 M14850 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 443/1011 Gene Ontology BP GO:0080135 4.9315955455701e-09 4.70279390287928e-08 3545 3153.09090909091 3481 4.48326868784086e-10 227 1.36932024033939 -1.08684885777852 -1 9.31404914945084 3544 3652 2802 4356 227 2259 3359 3726 3164 3481 4114 3859 M10551 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION.html The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. 68/151 Gene Ontology BP GO:0006353 0.0175561431880067 0.020615369960019 1540 3172.81818181818 3482 0.00160889343789861 1454 0.799383431970968 -0.779638019091515 -1 1.25092867542509 1539 4123 3482 4426 4350 1454 2276 2373 4274 4205 2399 3860 M16719 GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 18/72 Gene Ontology BP GO:0060119 0.000345103199660669 0.000478302733141638 3480 3563.63636363636 3482 3.13779405633598e-05 2510 1.46348672220747 1.94397301789727 1 4.51060565618169 3482 3478 2510 3051 3216 4343 4054 3788 3754 3478 4046 3861 M10141 GO_DENTATE_GYRUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENTATE_GYRUS_DEVELOPMENT.html The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. 6/19 Gene Ontology BP GO:0021542 0.000279993467323913 0.000390980351514264 4530 2952.09090909091 3484 2.80028751934849e-05 185 2.76712813336615 -2.11532840688171 -1 8.75342961413611 4526 3252 3542 1636 3484 3499 4385 1109 185 2516 4339 3862 M11429 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION.html Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. 12/23 Gene Ontology BP GO:0010569 0.251345148681763 0.260431940488602 3420 3605 3484 0.0259728591645746 2835 0.681356587677796 -0.619534056777357 -1 0.369558779643241 3416 3484 2842 3011 4000 2835 3416 4254 4434 4365 3598 3863 M11040 GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. 12/31 Gene Ontology BP GO:0045606 0.00435076461461038 0.00537679002013202 2795 3337.45454545455 3485 0.000396308424785877 1980 0.761410560615773 -0.491417854247319 -1 1.60403468217574 2791 3485 2893 4402 3542 1980 2320 4326 4362 3893 2718 3864 M14337 GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE.html Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. 6/12 Gene Ontology BP GO:0043097 0.00416818324818436 0.00516159665137726 2195 2973.90909090909 3485 0.00041760221378121 1415 0.875704597020179 -0.875704597020179 -1 1.85923331368034 2192 2026 4226 3862 3548 1415 1711 3485 4001 4511 1736 3865 M10630 GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. 10/23 Gene Ontology BP GO:0045618 0.00518147093145574 0.00636275311683391 2555 3122.18181818182 3487 0.000472155890491031 1302 0.761410560615773 -0.491417854247319 -1 1.55235306717128 2551 3487 2913 4203 3569 1302 1734 4458 4258 3791 2078 3866 M11708 GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/16 Gene Ontology BP GO:0032239 0.0765897756730953 0.0843068583333764 3235 3485.45454545455 3487 0.00793650793650794 2674 1.22703895073626 1.22703895073626 1 1.22345255906547 3232 3829 3793 4182 4214 3487 2674 3011 3982 3070 2866 3867 M13855 GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION.html The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. 19/34 Gene Ontology BP GO:0043687 0.00289220798847749 0.00363817981319452 3705 3331 3487 0.000263274292134713 1962 1.31083686856708 -0.66951645045855 -1 2.96790630817306 3704 3665 2847 4088 3487 1962 2835 3331 2484 4061 4177 3868 M14921 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT.html Any process that activates or increases the frequency, rate or extent of protein import. 82/215 Gene Ontology BP GO:1904591 4.94437725754074e-07 1.20298465477503e-06 4100 3370.36363636364 3488 4.49488942614754e-08 1835 1.63502620933494 -1.16288844486771 -1 8.9845530486219 4098 4190 2511 3761 1835 3202 3969 2861 3016 3488 4143 3869 M10079 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. 24/56 Gene Ontology BP GO:1903573 5.91660470954044e-07 1.40682090357639e-06 3975 3220.90909090909 3489 5.37873300066587e-08 1564 0.999531260124318 -0.924972130081751 -1 5.42940328239269 3972 2722 2957 3720 1877 1564 4269 3915 4283 3489 2662 3870 M12729 GO_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. 455/1026 Gene Ontology BP GO:0009894 1.59674592755709e-05 2.66700259284717e-05 3655 3300.27272727273 3489 1.45159774250424e-06 246 1.24143403995314 -1.02062704823792 -1 5.27092346041856 3652 4212 3435 4606 3280 246 3425 4154 3489 4232 1572 3871 M13244 GO_COVALENT_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COVALENT_CHROMATIN_MODIFICATION.html The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. 184/403 Gene Ontology BP GO:0016569 4.16805464132506e-05 6.47883418134323e-05 4605 2988.27272727273 3491 3.78921237285873e-06 344 0.90514053629328 -0.832660899483684 -1 3.51920022675691 1973 4604 3491 4605 4272 344 1977 2460 4027 4264 854 3872 M16704 GO_METAPHASE_PLATE_CONGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAPHASE_PLATE_CONGRESSION.html The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. 29/51 Gene Ontology BP GO:0051310 0.0867953591375651 0.0921332538810504 2500 3560.45454545455 3491 0.00822014489106546 1975 0.83134552172283 -0.570938744743904 -1 0.799163708009222 2496 4633 3013 4373 4412 1975 3038 3491 4573 4158 3003 3873 M14249 GO_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOR_SIGNALING.html Any process that modulates the frequency, rate or extent of TOR signaling. 45/108 Gene Ontology BP GO:0032006 0.00526358266129099 0.00645846043773099 4615 3401.72727272727 3492 0.000479656211336938 1506 1.07496941508712 -0.827757323351093 -1 2.18516251211687 4613 2462 3079 3492 3573 1506 3917 4498 3328 3885 3066 3874 M14653 GO_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ORGANELLE.html A process in which a protein is transported to, or maintained in, a location within an organelle. 334/807 Gene Ontology BP GO:0033365 0.000153766786712657 0.000221376493242439 3055 3232 3492 1.39797759217531e-05 499 1.24075511064132 -0.881136871039969 -1 4.20946545103547 3055 4469 3492 4165 3931 499 3153 3714 3262 4283 1529 3875 M15275 GO_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_MOVEMENT.html A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. 122/278 Gene Ontology BP GO:0007018 0.00021325284669754 0.000302146160273628 4400 3575.27272727273 3492 1.93885018877545e-05 2496 1.29101540904803 -1.17133631653533 -1 4.2180956798101 4398 4157 3004 4358 3150 2496 3664 3169 3492 3994 3446 3876 M16503 GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. 96/203 Gene Ontology BP GO:2001020 8.45376670136852e-05 0.000125482221209891 3625 3530.81818181818 3492 7.68553778643552e-06 2997 1.15823413238783 1.33045408676479 1 4.19457478308918 3625 3420 2997 3171 3004 3631 3906 3492 3469 3618 4506 3877 M16511 GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. 448/916 Gene Ontology BP GO:0006974 0.0353733823652758 0.0404727980093582 2250 3361.09090909091 3493 0.00326866236710637 1662 1.1637853180929 -1.03267775109589 -1 1.50467318316905 2246 4530 3493 4082 4287 1662 3110 3040 3739 4268 2515 3878 M10424 GO_RIBOSOME_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. 195/424 Gene Ontology BP GO:0042254 0.0403809771321184 0.0459756931889224 1525 3267.63636363636 3494 0.00374016305238434 1523 0.655010142506167 -0.653980802441325 -1 0.813208040870657 1523 4476 3494 3860 4029 1709 2917 2845 4249 4316 2526 3879 M11883 GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. 9/22 Gene Ontology BP GO:0035067 0.0414675673977475 0.0471781218886895 2810 3421.90909090909 3494 0.00422623226258954 1638 0.597763298437309 -0.506548232228639 -1 0.735913428694648 2806 3905 3820 3494 4151 2952 1638 3202 4294 4381 2998 3880 M16658 GO_LOCOMOTORY_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_EXPLORATION_BEHAVIOR.html The specific movement from place to place of an organism in response to a novel environment. 8/24 Gene Ontology BP GO:0035641 0.000123798029802021 0.000179904304341403 4580 3395.63636363636 3495 1.23804927021288e-05 871 1.07557679818802 -0.884542148485253 -1 3.73901792288671 4580 871 4597 2287 3082 3495 4152 3918 3334 2944 4092 3881 M10818 GO_RNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_STABILIZATION.html Prevention of degradation of RNA molecules. 26/44 Gene Ontology BP GO:0043489 0.0558210438246829 0.0628155856708684 3250 3432.72727272727 3496 0.00520816826942804 2172 1.91265399815163 1.80695569525725 1 2.13395679994511 3250 4291 2346 4188 3813 3726 2172 3496 3240 2783 4455 3882 M11015 GO_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_PROCESSING.html Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. 235/527 Gene Ontology BP GO:0006397 0.0532024352942379 0.059883371411187 2240 3490.27272727273 3496 0.00495766758597711 1802 0.95740265737865 -0.784847600224572 -1 1.08662923209959 2238 4473 3496 4430 4606 1802 3074 3367 4002 4292 2613 3883 M14943 GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. 8/29 Gene Ontology BP GO:1900271 0.000472695183496384 0.000645317182291594 2045 3046.09090909091 3496 4.72795761939646e-05 1215 0.834412992399079 0.834412992399079 1 2.47099416183269 2045 3496 4322 3729 3972 2402 1818 1215 4162 3656 2690 3884 M11750 GO_RNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLATION.html Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. 30/57 Gene Ontology BP GO:0001510 0.0364125589647797 0.0415798109378928 2470 3452.72727272727 3497 0.00336632497147837 1678 0.724738571093378 -0.733601755957706 -1 0.92913976511844 2470 4337 3245 4470 4612 1678 3497 2555 4431 4376 2309 3885 M12260 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. 101/247 Gene Ontology BP GO:1900182 2.86636537379348e-07 7.64833009489568e-07 4490 3395.18181818182 3497 2.60578704295489e-08 1671 1.44977001833677 -1.0488391550297 -1 8.23126332200117 4488 4216 2750 3497 1671 2602 4482 2836 3285 3874 3646 3886 M13085 GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION.html The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. 8/16 Gene Ontology BP GO:0071425 4.05584832841351e-05 6.32135071796707e-05 3075 3332.36363636364 3497 4.05592235489052e-06 2133 1.89806486473413 1.97376406752975 1 7.39853474281528 3072 3497 4009 2939 2892 4062 3537 4235 2472 2133 3808 3887 M11045 GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. 11/21 Gene Ontology BP GO:0003323 0.00314829468935684 0.00394577548526512 4100 3284.81818181818 3498 0.000286619007414556 374 1.96358351675683 -1.25795242863109 -1 4.38156288495187 4096 3991 2291 2996 3498 4016 4531 3084 374 3312 3944 3888 M11119 GO_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING.html The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. 254/612 Gene Ontology BP GO:0006605 0.000241309692674045 0.000339309782884795 3135 3193.09090909091 3498 2.19396513716588e-05 558 1.14490354230755 -0.930837123457101 -1 3.68716730756537 3135 4470 3498 4079 3664 558 3268 3330 3544 4269 1309 3889 M11174 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. 428/988 Gene Ontology BP GO:0070647 5.98587758064851e-05 9.07952617018981e-05 2540 3193 3499 5.44185495800827e-06 386 1.01930028387239 -0.899655799487813 -1 3.82437776445473 2539 4468 3499 4610 4529 386 2775 3007 3792 4294 1224 3890 M11875 GO_MEMBRANE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DOCKING.html The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. 33/78 Gene Ontology BP GO:0022406 0.0031486319562583 0.00394577548526512 4435 3577.54545454545 3499 0.000286649756064567 2453 0.993002662070717 -0.598242228270916 -1 2.21579748137923 4433 2775 2922 2453 3499 2918 4500 4110 3456 3888 4399 3891 M11272 GO_RRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. 157/371 Gene Ontology BP GO:0016072 0.0479736350435169 0.0542874939086154 4300 3372.27272727273 3501 0.00445935019329582 1771 0.631715658140064 -0.62932971203565 -1 0.741966408310805 1856 4479 3501 4003 4180 1771 3004 3138 4299 4298 2566 3892 M11476 GO_MALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GAMETE_GENERATION.html Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. 215/832 Gene Ontology BP GO:0048232 5.00337947031752e-09 4.71210768370877e-08 3440 3274.09090909091 3501 4.54852680154229e-10 237 1.46540773798773 1.66405842973781 1 9.96646277990536 3437 4472 2879 3969 237 2705 3655 3501 2693 3954 4513 3893 M13768 GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 40/88 Gene Ontology BP GO:0072527 0.00013047962028408 0.000189140454879483 3505 3381.09090909091 3501 1.18624872301671e-05 2516 1.20877042308349 -0.801899424655321 -1 4.17764110978222 3501 3656 2725 3565 3068 2516 3113 4530 2895 3924 3699 3894 M14179 GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION.html The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. 7/21 Gene Ontology BP GO:0043046 0.00291584584644508 0.00366592804360804 3570 3488.54545454545 3501 0.000291967889749453 1582 1.84662657559832 -0.591705497170933 -1 4.17534813931207 3317 3968 4199 3412 3501 4551 3570 3499 1582 3566 3209 3895 M10260 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. 61/134 Gene Ontology BP GO:0002504 3.80786588605203e-08 1.6146046857479e-07 4385 3207.09090909091 3502 3.461696319964e-09 991 1.40752479772324 -1.52746064415202 -1 8.87398378779898 4381 2845 2278 3622 991 3502 3697 4079 3182 2949 3752 3896 M11490 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE.html The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 223/551 Gene Ontology BP GO:0072594 4.4410450253881e-05 6.87325735095899e-05 2055 2963.81818181818 3502 4.037395161255e-06 352 0.943229778673829 -0.835365482220026 -1 3.64481985772221 2053 4537 3502 4167 4161 352 2216 2426 3986 4289 913 3897 M16590 GO_AZOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AZOLE_TRANSPORT.html The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/15 Gene Ontology BP GO:0045117 0.0903806016466909 0.095873231310392 3505 3661.54545454545 3502 0.00942817446714064 2490 1.19306608944343 -1.19306608944343 -1 1.12774376112773 3502 4524 4587 3836 4571 2713 2797 3250 4544 3463 2490 3898 M11964 GO_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PROCESSING.html Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. 477/1051 Gene Ontology BP GO:0006396 0.0137840855357426 0.0163430820077765 1620 3312.63636363636 3503 0.00126101953357684 1373 0.89668526655636 -0.741132524490092 -1 1.48714220581729 1620 4529 3503 4521 4496 1373 2865 2855 3963 4387 2327 3899 M13258 GO_FC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 108/363 Gene Ontology BP GO:0038093 0.00698152130778326 0.00847234799582793 3505 3159.72727272727 3503 0.000636706866575968 1176 1.54623394009915 -0.993412301496947 -1 2.9739473246458 3503 3884 3228 2959 4497 1176 3809 3974 1887 4023 1817 3900 M15120 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. 61/134 Gene Ontology BP GO:0002495 3.80786588605203e-08 1.6146046857479e-07 4385 3209.72727272727 3503 3.461696319964e-09 992 1.40752479772324 -1.52746064415202 -1 8.87398378779898 4382 2846 2279 3623 992 3503 3698 4098 3183 2950 3753 3901 M13429 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 122/268 Gene Ontology BP GO:0015931 0.0182088501811928 0.0213278737112206 2720 3331.18181818182 3505 0.0016692118263582 1889 1.11403888922627 -1.19600930108815 -1 1.72806280047025 2719 4431 3440 4427 3834 1889 3505 2001 3857 4230 2310 3902 M12423 GO_NCRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_PROCESSING.html Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. 239/510 Gene Ontology BP GO:0034470 0.0065428157240126 0.00795451516276264 1120 3065.09090909091 3506 0.000596577773576655 1119 0.716547880083519 -0.704712391720847 -1 1.39638974334684 1119 4357 3506 4309 3985 1155 2519 2296 4085 4414 1971 3903 M11110 GO_NCRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of a non-coding RNA molecule. 10/22 Gene Ontology BP GO:0043628 0.00329926186420834 0.00412674375956879 3360 3485.72727272727 3507 0.000300383642096814 2459 0.530355133052018 -0.530355133052018 -1 1.17385266391802 3358 3531 3159 3591 3507 2459 2978 4101 4254 4348 3057 3904 M12606 GO_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR.html The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 285/574 Gene Ontology BP GO:0006281 0.0172834658709282 0.0203157296300556 935 3122.36363636364 3507 0.00158370539029009 935 1.03368893677725 -0.936275750662795 -1 1.62368704280595 935 4535 3507 4166 4204 1450 2384 2645 3971 4287 2262 3905 M16759 GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA.html The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. 12/29 Gene Ontology BP GO:0070918 0.11721143248013 0.123572361717812 3900 3474.54545454545 3507 0.0112696126531558 2809 0.93952851895675 -0.733883906717752 -1 0.79195857284367 3622 3898 3085 2841 3896 2809 3433 3507 4286 3908 2935 3906 M11898 GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. 13/28 Gene Ontology BP GO:1903205 0.000922932498061403 0.00121841785285729 4040 3446.54545454545 3508 8.39381735846878e-05 2340 1.19855601085044 -0.568048229897021 -1 3.24225643840335 3173 3960 2632 4037 3346 4036 2340 3532 3858 3508 3490 3907 M14464 GO_DSRNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DSRNA_FRAGMENTATION.html Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. 12/29 Gene Ontology BP GO:0031050 0.11721143248013 0.123572361717812 3625 3473.36363636364 3508 0.0112696126531558 2808 0.93952851895675 -0.733883906717752 -1 0.79195857284367 3621 3897 3084 2840 3895 2808 3432 3508 4285 3903 2934 3908 M10418 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 33/100 Gene Ontology BP GO:0042509 9.89333565531958e-07 2.20187705721744e-06 3725 3439.18181818182 3509 8.9939455493877e-08 2013 1.33165304230575 -0.933980713398055 -1 6.99297990401543 3723 3204 2295 4139 2013 3935 4203 3179 3509 3000 4631 3909 M13371 GO_NCRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). 313/678 Gene Ontology BP GO:0034660 0.00357346448880887 0.00445531568784629 870 2976.81818181818 3509 0.000325389282561314 870 0.824554724744505 -0.77299367855185 -1 1.79954890591856 870 4320 3509 4476 3794 997 2388 2068 3934 4463 1926 3910 M12244 GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE.html Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. 9/12 Gene Ontology BP GO:0048875 0.00406825941710649 0.00504511978462217 4610 3039.90909090909 3511 0.000407572649430945 1134 2.18896767289264 -2.57543709502381 -1 4.66760143402631 4607 2963 3874 2201 3544 4265 3857 2047 1436 1134 3511 3911 M12535 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. 33/88 Gene Ontology BP GO:0032735 0.0521025069656699 0.0587164902528168 3515 3269.81818181818 3511 0.00485263431219572 2222 1.51858608780462 -1.49158956906615 -1 1.73560620174063 3511 3717 2222 3601 3800 2858 4052 3147 3562 2612 2886 3912 M13539 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. 123/271 Gene Ontology BP GO:0071826 0.00327835894436274 0.00410170320093672 4275 3125.36363636364 3511 0.000298477677297106 980 0.878698251814824 -0.894763000633143 -1 1.94700822354933 1868 4433 3511 4164 4290 980 2357 2442 4275 4272 1787 3913 M12744 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION.html Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. 82/173 Gene Ontology BP GO:0071166 0.264590770347443 0.273911916772169 2980 3690.72727272727 3512 0.0275522414107065 2438 0.933394795991695 -1.08844274318098 -1 0.487271723229823 2980 4618 3465 4308 4237 2438 3512 3364 4342 4266 3068 3914 M13799 GO_PROTEIN_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION.html The process in which one or more ubiquitin groups are added to a protein. 303/718 Gene Ontology BP GO:0016567 8.03529538588266e-07 1.83241043598493e-06 2430 3019.72727272727 3512 7.30481665518278e-08 79 0.988075022572686 -0.884043522098177 -1 5.26189495144795 2426 4400 3512 4609 4329 79 2510 2790 3702 4277 583 3915 M14381 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. 273/602 Gene Ontology BP GO:0022613 0.0177009177899366 0.0207643661694481 1425 3284.72727272727 3513 0.00162226929894931 1421 0.694135249467804 -0.694258032439752 -1 1.08421405688182 1421 4471 3513 4170 4212 1459 2804 2959 4300 4516 2307 3916 M16723 GO_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_TRANSPORT.html The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 35/102 Gene Ontology BP GO:0015833 0.0237312699914821 0.0275667467026398 3340 3451.81818181818 3513 0.00218101742160189 1818 1.57187929805433 -0.851900227457864 -1 2.27565047179113 3336 3513 1818 4022 3715 4630 3231 3583 3197 2779 4146 3917 M12311 GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. 17/50 Gene Ontology BP GO:0000060 0.000507831777787238 0.000690443029067686 3435 3551.09090909091 3514 4.61771854388203e-05 2561 1.30244031703857 -0.958736280719652 -1 3.8215001459791 3432 4129 2627 4134 3256 3693 2561 4601 3514 3357 3758 3918 M12920 GO_APOPTOTIC_NUCLEAR_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_NUCLEAR_CHANGES.html Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. 13/32 Gene Ontology BP GO:0030262 0.00238843304767288 0.00302197271173894 3620 3577.54545454545 3514 0.000217366363756252 2522 1.02873066560449 -0.970966598300953 -1 2.40614202376685 3619 4508 2777 4502 3462 2522 3094 3895 4344 3514 3116 3919 M13704 GO_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_LOCALIZATION.html Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. 13/39 Gene Ontology BP GO:0051647 0.00206160661070296 0.00262805645294353 4160 3182.72727272727 3515 0.000187594642551135 521 2.65759692803388 -1.07704823006263 -1 6.36560133471584 4158 4267 2253 3287 4265 3350 4131 1502 521 3515 3761 3920 M15918 GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. 4/13 Gene Ontology BP GO:0002320 0.00262280184407333 0.00330735170071496 4235 3115.72727272727 3515 0.00026259025862615 1021 1.45463075908332 -1.47606136589554 -1 3.34938097475174 4233 1827 4479 1714 3486 3515 3784 4346 1021 2094 3774 3921 M16331 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. 272/624 Gene Ontology BP GO:0045786 6.44959692983495e-08 2.33310263660409e-07 3050 3387.36363636364 3516 5.86327010810327e-09 1182 1.36331416264736 1.59828010918072 1 8.39293631541793 3047 4249 3072 3846 1182 3516 3675 3436 3222 3765 4251 3922 M16770 GO_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METABOLIC_PROCESS.html Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. 418/1006 Gene Ontology BP GO:0006259 0.0693603263512776 0.0774693277000198 1420 3352.81818181818 3519 0.00651352245948517 1419 1.09453135477835 -0.888064044816075 -1 1.12865339607343 1419 4531 3519 4168 4128 1896 2848 3337 3941 4297 2797 3923 M11003 GO_POLYOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 47/118 Gene Ontology BP GO:0019751 1.41362248768803e-07 4.29322199725598e-07 4495 3362.45454545455 3521 1.28511143501923e-08 1448 1.22669451946177 -1.18076192164616 -1 7.25028673856006 4495 3470 2625 4523 1448 3188 3521 3654 3677 3537 2849 3924 M12293 GO_ANDROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 10/34 Gene Ontology BP GO:0006702 0.000355309211521623 0.000492007357320279 3570 3144.90909090909 3523 3.23060553113799e-05 1144 4.18058173273891 -4.18058173273891 -1 12.837341180194 3567 3992 2117 3523 3829 3361 4509 1144 2269 3801 2482 3925 M15572 GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION.html Any process that modulates the frequency, rate or extent of cytoplasmic translation. 8/17 Gene Ontology BP GO:2000765 0.000163271716693634 0.000234478991836851 3530 3401 3526 1.63283713878288e-05 2193 1.0333822121652 -1.0333822121652 -1 3.48196409229553 3526 2193 4426 3147 3125 2975 4290 4072 3569 3659 2429 3926 M11060 GO_3_UTR_MEDIATED_MRNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_UTR_MEDIATED_MRNA_STABILIZATION.html An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. 11/16 Gene Ontology BP GO:0070935 0.0117751601714772 0.0140364746280279 3970 3386.09090909091 3527 0.00107624193104553 1939 1.48849821140587 -1.51895849684099 -1 2.55995517552014 3967 3527 2671 2825 3650 4274 2994 4213 1939 2650 4537 3927 M11747 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion. 8/14 Gene Ontology BP GO:2000484 0.0205227411548409 0.0239114396943354 2915 3396.81818181818 3527 0.00207147742037811 2553 2.09319985054377 -1.74666645914289 -1 3.15041991605781 2912 3759 3799 3527 3711 3727 2553 3235 3826 2913 3403 3928 M10061 GO_L_PHENYLALANINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. 7/12 Gene Ontology BP GO:0006558 2.71222983949232e-05 4.36041660137218e-05 4255 3590.18181818182 3528 2.71226294291911e-06 2712 1.03742048211165 -1.05009187337811 -1 4.19911185036666 4253 3161 3528 3385 2807 3387 4433 4552 3603 2712 3671 3929 M14652 GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. 5/12 Gene Ontology BP GO:0051292 0.275742742869669 0.285011922338351 3300 3707.72727272727 3528 0.0317460317460317 2968 0.763325331403914 -0.763325331403914 -1 0.386263993260086 3297 4031 4266 3364 4094 2968 3076 3528 4231 4528 3402 3930 M13735 GO_POSITIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPAIR.html Any process that activates or increases the frequency, rate or extent of DNA repair. 27/61 Gene Ontology BP GO:0045739 0.000170951439933415 0.000244902047396127 3530 3408.18181818182 3529 1.55422477449573e-05 2241 0.977316529782127 -0.830462541798367 -1 3.27591602145153 3529 3636 3000 3743 3118 2241 3209 4266 3933 3922 2893 3931 M11879 GO_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 21/48 Gene Ontology BP GO:0032069 0.000118455836473554 0.000172464863200599 4570 3613.63636363636 3531 1.07692922762328e-05 2360 0.888390796008319 -0.826885946433046 -1 3.10342984381967 4570 3956 3093 3249 3058 2360 4458 3478 4049 3948 3531 3932 M13124 GO_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that modulates the frequency, rate, or extent of mast cell activation. 25/56 Gene Ontology BP GO:0033003 1.26802653073708e-05 2.15973851144983e-05 4100 3439.81818181818 3533 1.15275803581163e-06 2358 1.02211950114854 1.11983445250082 1 4.4266806249019 4100 2358 2772 3045 2631 3313 3819 4622 3533 3536 4109 3933 M10114 GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 8/25 Gene Ontology BP GO:0090185 7.10535122231347e-08 2.51449281442084e-07 4120 2460.09090909091 3535 7.10535144950054e-09 48 2.76368875376083 -2.57190783236841 -1 16.9306084335811 4120 235 3535 198 1260 3741 4560 4228 48 644 4492 3934 M12690 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. 31/84 Gene Ontology BP GO:0032873 4.14545417577099e-07 1.03927341998406e-06 3535 3280.36363636364 3535 3.76859541536184e-08 1779 1.47385216403211 -0.897680200246583 -1 8.18581017055032 3535 3472 2517 4114 1779 4468 3545 2358 2390 3585 4321 3935 M14492 GO_TRACHEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_MORPHOGENESIS.html The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. 8/21 Gene Ontology BP GO:0060439 0.00383198584672398 0.00476356366434791 3540 3343.63636363636 3536 0.000383860978015601 1907 1.79756298236359 -1.90738190147614 -1 3.87461159542001 4448 3494 4245 1936 3539 3536 4393 2635 1907 2929 3718 3936 M14839 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 31/84 Gene Ontology BP GO:0070303 4.14545417577099e-07 1.03927341998406e-06 3540 3271.81818181818 3536 3.76859541536184e-08 1780 1.47385216403211 -0.897680200246583 -1 8.18581017055032 3536 3473 2518 4115 1780 4469 3546 2254 2391 3586 4322 3937 M14997 GO_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_RESORPTION.html Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). 16/43 Gene Ontology BP GO:0045124 0.00416603077751748 0.00516159665137726 3355 3466.09090909091 3536 0.000379449160124767 2174 1.84061466111193 -2.54130270645391 -1 3.9078615139811 4449 3553 2174 3905 3536 3353 4283 2548 3355 3260 3711 3938 M10119 GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that stops or reduces the activity of a phosphoprotein phosphatase. 8/18 Gene Ontology BP GO:0032515 0.0765897756730953 0.0843068583333764 4530 3469.63636363636 3537 0.00793650793650794 2122 1.25272983729114 -1.43426068869622 -1 1.24906836051918 4530 2896 3537 2654 3883 4211 3684 2705 3389 2122 4555 3939 M15445 GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. 5/20 Gene Ontology BP GO:0036148 0.0158658706234055 0.0187205177393829 3540 3540 3537 0.00159802987605182 1986 1.47157038893948 -1.47157038893948 -1 2.36001079733676 3537 4397 4406 4199 4573 2730 2884 1986 4170 3292 2766 3940 M15796 GO_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. 8/31 Gene Ontology BP GO:0032528 0.00492280660623603 0.00605312263579287 2100 3250.90909090909 3538 0.000493374603958339 1046 0.702454944442714 0.702454944442714 1 1.44628244882097 2099 3674 4458 3538 4610 2214 1046 2573 4220 4592 2736 3941 M10125 GO_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION.html A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. 530/1244 Gene Ontology BP GO:0051276 0.0389302191455494 0.0443783470397215 1610 3359.18181818182 3539 0.00396295268472742 1608 1.21585834029597 -1.03754508706931 -1 1.52684491752677 1608 4528 3539 4239 4604 1731 2814 3129 3888 4288 2583 3942 M12117 GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. 17/35 Gene Ontology BP GO:0060765 5.64980881346383e-07 1.35426238104866e-06 4225 3330.54545454545 3539 5.13619114944443e-08 1400 0.864573628538111 -0.755732632955899 -1 4.70959115720875 4223 1400 2846 2615 1862 3756 4559 3539 3850 3356 4630 3943 M10534 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS.html Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 9/17 Gene Ontology BP GO:0010561 0.00490749645023023 0.00603589563401827 3600 3176.54545454545 3540 0.00049183678392625 2071 1.37680554347179 1.52027777000652 1 2.83628302344528 3540 2071 3600 3383 3576 2581 3751 3596 3772 2334 2738 3944 M14470 GO_LYMPH_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. 5/17 Gene Ontology BP GO:0036303 0.0500885438291034 0.0565704473360563 4575 3590.90909090909 3540 0.00512546999880761 2528 2.11532840688171 -2.11532840688171 -1 2.44938054359929 4572 3540 4241 2528 3810 4470 3604 3517 2841 3287 3090 3945 M16567 GO_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. 22/56 Gene Ontology BP GO:0051972 8.13754643990064e-05 0.000121098167052752 4480 3242.45454545455 3540 7.39804313995682e-06 1500 1.94328226768692 2.12231936216139 1 7.0655070788019 4478 3661 2392 2952 2996 2743 3540 3860 1500 3712 3833 3946 M14071 GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 47/90 Gene Ontology BP GO:0071479 0.00430855257548714 0.0053260408966951 2905 3434.09090909091 3541 0.000392455799556087 2020 1.20342837647724 1.51005874983527 1 2.53981776625171 2904 3919 2920 3684 3541 4498 3441 2020 3166 3772 3910 3947 M15279 GO_RESPONSE_TO_HYDROPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROPEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. 13/26 Gene Ontology BP GO:0033194 0.00129515639232122 0.00168726462669681 3965 3449.36363636364 3541 0.000117810862686473 2067 1.81845987613383 -1.81845987613383 -1 4.68051910892611 3964 3935 2409 3659 3383 3558 4510 2067 3398 3519 3541 3948 M15678 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 5/16 Gene Ontology BP GO:0043455 0.000133497762953915 0.000193033358266904 3935 3106.18181818182 3541 1.3350578337576e-05 112 3.40604878429556 -1.74666645914289 -1 11.7436982863818 3934 3541 4439 1893 3090 4168 4124 2750 112 2290 3827 3949 M16752 GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT.html Any process that modulates the frequency, rate or extent of synaptic vesicle transport. 22/58 Gene Ontology BP GO:1902803 1.08848261943613e-05 1.87734948069909e-05 3635 3381.54545454545 3541 9.8953454991144e-07 2319 1.18320647080926 1.10962334759355 1 5.1911691114882 3631 2319 2760 3104 2605 4194 4070 3859 3541 2877 4237 3950 M10919 GO_CHROMOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION.html Any process in which a chromosome is transported to, or maintained in, a specific location. 40/72 Gene Ontology BP GO:0050000 0.09417392919645 0.0998103283081594 4165 3646.27272727273 3543 0.00895132944581058 1999 0.916756239016953 -0.570938744743904 -1 0.851688626498942 3056 4627 3188 4161 4458 1999 3201 3543 4531 4161 3184 3951 M10940 GO_CELLULAR_RESPONSE_TO_SUPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_SUPEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. 7/21 Gene Ontology BP GO:0071451 0.0512692603411065 0.0578195714752872 3425 3552.63636363636 3543 0.00524919967179087 2619 0.845176327750378 -0.845176327750378 -1 0.97120465510189 3421 4146 3660 3486 3815 2745 2968 4540 4136 3543 2619 3952 M11057 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 6/14 Gene Ontology BP GO:0033147 0.00152697557325547 0.00197486005198473 3545 3380.72727272727 3543 0.000152802583356885 1811 1.42327525591595 -1.42327525591595 -1 3.57305062154729 3543 4148 3679 3717 3414 2658 3691 1811 4288 3416 2823 3953 M10151 GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION.html The acetylation of the N-terminal amino acid of proteins. 6/15 Gene Ontology BP GO:0006474 0.0644500060697102 0.0721759233433827 2760 3409.63636363636 3544 0.00663992699739915 1902 0.542534159845371 -0.542534159845371 -1 0.574927321126138 2760 3969 3544 3903 4345 1902 2559 3433 4251 4306 2534 3954 M14828 GO_MEMBRANE_HYPERPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_HYPERPOLARIZATION.html The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. 8/21 Gene Ontology BP GO:0060081 1.67962817182275e-06 3.49380175732097e-06 4185 3290.63636363636 3544 1.67962944134196e-07 1534 1.46042294947228 -1.34246701239513 -1 7.39738113595116 4184 3561 4299 3282 2187 3919 4085 1534 2669 2933 3544 3955 M10159 GO_NEURONAL_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_DIVISION.html The self-renewing division of a neuronal stem cell. 6/21 Gene Ontology BP GO:0036445 1.38822885066795e-07 4.23213824927858e-07 4200 3164.90909090909 3545 1.38822893739103e-08 1468 1.32265195591073 -1.42965528460233 -1 7.82507703298287 4198 1639 3545 2672 1468 3811 4021 4145 2443 2517 4355 3956 M11046 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION.html Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. 7/17 Gene Ontology BP GO:0032928 0.182211247122061 0.19067090835874 2440 3343.72727272727 3545 0.0199141630264511 2282 0.989238738547773 -0.989238738547773 -1 0.660892796160209 2438 3806 3675 4403 4124 2282 2305 3065 4313 3545 2825 3957 M13091 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. 63/138 Gene Ontology BP GO:0002474 0.0155123969007124 0.0183313969992384 2400 3166.90909090909 3545 0.00142026075192086 1409 1.15996417655969 -0.791355154568462 -1 1.87009897365605 2399 3916 3323 3609 4016 1409 2250 3686 3545 4054 2629 3958 M14426 GO_GROOMING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROOMING_BEHAVIOR.html The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. 6/18 Gene Ontology BP GO:0007625 0.00413054873823758 0.00511963101752191 4185 3284.81818181818 3545 0.000413824652820235 1017 1.92618884805006 -0.976344355556222 -1 4.09588570844525 4181 2340 4235 2009 3545 4059 4466 3109 1017 2544 4628 3959 M13615 GO_DIOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. 6/12 Gene Ontology BP GO:0034311 1.69718034883518e-07 4.96534868282404e-07 3880 3130 3546 1.69718047845414e-08 1422 1.08617962426447 -1.06047086957244 -1 6.35609597173884 3877 1422 4105 2504 1545 3546 4027 3628 3529 2538 3709 3960 M11283 GO_RESPONSE_TO_FUNGICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. 7/20 Gene Ontology BP GO:0060992 0.000612222021894775 0.00082321078704241 4510 3495.18181818182 3549 6.12390754434748e-05 2492 2.18046988939203 2.18046988939203 1 6.24313089031131 4510 2570 3723 2701 3295 2910 3741 4349 2492 3549 4607 3961 M15153 GO_REGULATION_OF_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_MOVEMENT.html Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. 7/27 Gene Ontology BP GO:0003352 0.219805793572135 0.228619690760624 2940 3664.27272727273 3549 0.0245157267379012 2542 0.21787992825891 -0.21787992825891 -1 0.129618417859347 2939 4280 4362 3549 4025 2542 3346 2811 4590 4555 3308 3962 M13181 GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 11/22 Gene Ontology BP GO:0071243 0.149862663847851 0.157103713760572 4190 3536.54545454545 3550 0.0146513696242982 2245 0.973174992625261 -0.882847773266104 -1 0.726131509687668 3550 3452 2857 4189 4088 2245 4132 4190 4236 3322 2641 3963 M15211 GO_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRITY_CHECKPOINT.html A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. 92/197 Gene Ontology BP GO:0031570 0.0683475750511721 0.0764117002077034 3845 3428.36363636364 3551 0.00641528530072199 2495 1.30183716725382 -1.20282933405333 -1 1.34963631764391 2701 4253 3018 3845 3843 2495 3250 3551 3560 4081 3115 3964 M10192 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT.html The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/32 Gene Ontology BP GO:0043252 0.000395953045594487 0.000545037056239313 2255 3174.90909090909 3552 3.96023613757968e-05 552 0.580788816455334 0.832742822181803 1 1.75946567031865 2003 4181 3552 4588 4026 2253 552 2253 4308 4308 2900 3965 M10528 GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/20 Gene Ontology BP GO:0010766 0.00430127778057027 0.00531846411056931 3550 3436.81818181818 3552 0.000430962597698027 2232 1.37816321076759 -0.900158819796175 -1 2.90938401622146 3549 2763 3599 3110 3552 3492 2232 4174 3628 3636 4070 3966 M10208 GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION.html The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. 6/25 Gene Ontology BP GO:0021889 0.0765897756730953 0.0843068583333764 4205 3565.36363636364 3553 0.00793650793650794 2520 1.85752509393684 -1.74666645914289 -1 1.85209602098113 4202 3416 3553 2714 4562 3609 4411 3439 2807 2520 3986 3967 M10211 GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. 9/14 Gene Ontology BP GO:0008608 0.201182709006575 0.210144278496632 2220 3418.36363636364 3554 0.0222119039666574 2216 0.526191726343499 -0.526191726343499 -1 0.330910788360167 2216 4241 3554 3675 4170 2325 2447 3148 4575 4309 2942 3968 M11010 GO_NEGATIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RNA_SPLICING.html Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. 18/50 Gene Ontology BP GO:0033119 0.0367746027426376 0.0419725861686495 4200 3445 3554 0.00340037261123588 1683 1.21907478952994 1.21907478952994 1 1.55827529135209 3130 4197 3308 3554 4197 1683 3011 3815 4436 4041 2523 3969 M12155 GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. 271/568 Gene Ontology BP GO:0010608 0.00208938660398696 0.00266146008293867 3565 3484.18181818182 3555 0.000190124871010173 1606 1.32722767070563 -0.947314494553086 -1 3.17228021823805 3565 4356 3447 3854 3442 1606 3555 4292 2975 4138 3096 3970 M13953 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. 15/41 Gene Ontology BP GO:1904358 0.089151889216069 0.0945914583250019 3065 3564.54545454545 3555 0.00845308132503251 1986 0.902795291110037 -0.902795291110037 -1 0.858264360837305 3061 4385 3196 3555 4623 1986 2272 4073 4582 4498 2979 3971 M15900 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein. 4/20 Gene Ontology BP GO:0042510 0.0039776642534641 0.00493936751239203 3555 3828.63636363636 3555 0.000398480205731047 3218 0.699236980605126 -0.796724734759611 -1 1.49697541384234 3555 3438 4476 3469 3543 3218 4508 3555 4384 4595 3374 3972 M12541 GO_ARACHIDONIC_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_SECRETION.html The controlled release of arachidonic acid from a cell or a tissue. 2/14 Gene Ontology BP GO:0050482 0.0699546487562971 0.0781143420335467 3375 3565.2 3556 0.00802561354693126 2473 0.265026543363888 -0.265026543363888 -1 0.272402705947941 3375 3737 3927 NA 4071 2955 2995 2473 4537 4422 3160 3973 M15723 GO_ARACHIDONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONATE_TRANSPORT.html The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 2/14 Gene Ontology BP GO:1903963 0.0720212565812217 0.0803640217031032 3380 3636.4 3557 0.00827076878708683 2491 0.265026543363888 -0.265026543363888 -1 0.269369145166865 3376 3738 4448 NA 4072 2956 2996 2491 4538 4588 3161 3974 M16045 GO_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 667/1589 Gene Ontology BP GO:0033043 5.50335883279789e-09 4.97122471997677e-08 3325 3304.90909090909 3557 5.50335884642702e-10 297 1.48547983023566 -1.07333990158883 -1 10.07091900193 3324 4466 4500 3557 297 2375 3573 2864 2778 4055 4565 3975 M14373 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 94/240 Gene Ontology BP GO:0043242 0.00127765493315473 0.00166493175824794 3920 3504.72727272727 3558 0.000116217957997223 2387 1.44477267462484 -1.17453487474352 -1 3.72644937696328 3916 4405 2527 4136 3381 2387 4614 3558 3254 3702 2672 3976 M14409 GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of a different species. 430/1069 Gene Ontology BP GO:0044419 0.000870956062577477 0.0011527505697113 3125 3672.45454545455 3558 7.92091868938127e-05 1614 1.43359569274287 -1.07169365414979 -1 3.91008967684122 4450 4597 3430 3558 3337 1614 4502 4435 3124 4225 3125 3977 M11225 GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. 202/480 Gene Ontology BP GO:1903651 2.84494246809862e-08 1.32355389572965e-07 3560 3174.27272727273 3559 2.58631136808015e-09 883 1.52449332493939 -1.10871184613233 -1 9.73359216717333 3559 3948 2548 4231 883 2659 3791 2269 2864 3590 4575 3978 M16124 GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. 430/1069 Gene Ontology BP GO:0044403 0.000870956062577477 0.0011527505697113 4455 3672.45454545455 3559 7.92091868938127e-05 1615 1.43359569274287 -1.07169365414979 -1 3.91008967684122 4451 4598 3431 3559 3338 1615 4503 4425 3125 4226 3126 3979 M12863 GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). 7/17 Gene Ontology BP GO:1901070 0.0111425055817325 0.0133199416621997 1850 2987.72727272727 3560 0.00111987730082266 1434 1.15376761301191 -1.15376761301191 -1 2.00864862898383 1849 3854 3971 4016 3753 1434 1861 2819 3902 3560 1846 3980 M10289 GO_NCRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). 9/26 Gene Ontology BP GO:0034661 0.000674477922876698 0.000902478673174787 3485 3664.63636363636 3562 6.7468272457792e-05 2815 0.579852364825619 -0.579852364825619 -1 1.63874542989632 3481 3586 3562 4327 3315 2815 3478 3741 4316 4311 3379 3981 M15870 GO_CELLULAR_MACROMOLECULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULE_LOCALIZATION.html Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 715/1626 Gene Ontology BP GO:0070727 2.04921116378759e-06 4.12955183744175e-06 3565 3158.81818181818 3562 2.04921305345992e-07 361 1.37740221614021 -1.1235799136165 -1 6.88403054426615 3562 4318 4470 4289 2250 361 3651 3459 2593 4208 1586 3982 M11463 GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL.html The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. 983/2289 Gene Ontology BP GO:0051649 1.66544489356245e-06 3.46911648309128e-06 3525 3185.27272727273 3563 1.66544614173178e-07 517 1.37870388272933 -1.12449629857399 -1 6.98739605643637 3524 4594 3750 4563 2183 517 3563 3657 2859 4252 1576 3983 M14154 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. 26/69 Gene Ontology BP GO:0060761 4.3614864294198e-06 8.12941850333043e-06 4525 3518.09090909091 3563 3.96499552369431e-07 2407 1.15898297983646 1.12267480676479 1 5.475942654459 4521 2915 2694 4186 2407 3410 4513 3945 3563 2788 3757 3984 M14674 GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. 96/234 Gene Ontology BP GO:1901796 6.29720128695295e-06 1.13910715604202e-05 4000 3501.09090909091 3563 5.72474482900803e-07 2353 1.15438705310037 -0.811203208921875 -1 5.29723741482552 3999 3440 3152 3984 2480 2353 3689 4589 3249 4014 3563 3985 M14802 GO_ACETYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. 7/12 Gene Ontology BP GO:0006085 0.00454596290135803 0.00560906344698521 2635 3200.09090909091 3563 0.000455528936490263 1236 0.328789034457426 -0.328789034457426 -1 0.687041526040206 2634 3707 4295 3975 3563 1236 1943 2427 4588 4536 2297 3986 M13952 GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE.html Any process that modulates the frequency, rate or extent of stem cell population maintenance. 7/22 Gene Ontology BP GO:2000036 0.000374138814667303 0.000516694383254101 2510 2869.81818181818 3564 3.74201820531031e-05 17 4.44455821572974 4.44455821572974 1 13.5602143566718 2506 4081 4164 1643 4168 3849 3864 1169 17 3564 2543 3987 M13203 GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE.html Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 21/43 Gene Ontology BP GO:0072595 0.00788171330961968 0.00952355108821932 2570 3325.45454545455 3566 0.000719099341375556 1209 0.769188710877941 -0.679211495147541 -1 1.44315010408894 2567 4379 3253 4057 4037 1209 2711 3566 4320 4089 2392 3988 M16342 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM.html Any process that modulates the frequency, rate or extent of defense response to bacterium. 7/15 Gene Ontology BP GO:1900424 3.0020324902853e-05 4.79643387900711e-05 3595 2943.36363636364 3566 3.00207304595221e-06 913 1.50253364424977 -2.07093884071082 -1 6.0239968472932 3595 983 4551 1227 2829 3852 3566 3653 913 2759 4449 3989 M15635 GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. 10/22 Gene Ontology BP GO:0000097 0.000233967074340306 0.000329584079539454 4475 3508.63636363636 3567 2.12719963757091e-05 2308 1.65288607905469 -2.1122449745662 -1 5.34250610360693 4472 3062 2367 3567 3161 4239 4218 3396 2308 3820 3985 3990 M14554 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. 93/194 Gene Ontology BP GO:1901988 1.16597312056576e-05 1.99911861107342e-05 3585 3516.09090909091 3568 1.05998118193336e-06 2619 1.43101563089605 1.60237770561903 1 6.24214526081089 3581 4092 2899 3548 2619 3664 4154 3568 2924 3301 4327 3991 M12573 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 149/314 Gene Ontology BP GO:0010948 2.67138276104444e-06 5.2334304470588e-06 3570 3697.09090909091 3570 2.42853273165114e-07 2294 1.29095431368679 1.58747939550467 1 6.32868863900682 3570 4478 3147 4070 2294 3517 4228 3513 3339 4065 4447 3992 M11297 GO_CARBOHYDRATE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHORYLATION.html The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. 10/24 Gene Ontology BP GO:0046835 0.000524361627354853 0.000711250667779312 2740 3175.90909090909 3571 4.76806044248029e-05 1048 1.13980806829516 -1.13980806829516 -1 3.33067637324433 2737 4208 2991 4116 3571 1994 3828 2447 4199 3796 1048 3993 M12360 GO_ENAMEL_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENAMEL_MINERALIZATION.html The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. 4/13 Gene Ontology BP GO:0070166 2.59772906270882e-05 4.19376079212693e-05 2080 3170.27272727273 3571 2.59775943009171e-06 1974 1.24806512969931 1.18140756846498 1 5.0713343600939 3571 1974 3896 2076 2796 4290 3797 4336 2363 2077 3697 3994 M11125 GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. 35/118 Gene Ontology BP GO:0045824 0.00766898945779413 0.00927268699284848 4595 3383.45454545455 3572 0.000699623092645075 2055 1.89274852040888 -0.926335083796436 -1 3.57153975335405 4593 3632 2166 3522 3612 3572 4409 2055 2277 2778 4602 3995 M15932 GO_RNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 148/362 Gene Ontology BP GO:0006401 0.0276094294557477 0.0318644247981697 3030 3495.63636363636 3572 0.00254201211800517 1596 0.925162074619216 -0.77263794975293 -1 1.28534552004872 3029 4612 3517 4004 4263 1596 3150 3572 4035 4290 2384 3996 M11436 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 9/31 Gene Ontology BP GO:0010804 0.0222075070631171 0.0258225532917738 3705 3491.18181818182 3574 0.00224326075845924 2699 1.29976591004911 -1.25307885451008 -1 1.91595347950475 3701 2699 3746 3574 3720 2959 4100 4083 3495 3069 3257 3997 M11114 GO_MITOCHONDRIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSPORT.html Transport of substances into, out of or within a mitochondrion. 120/271 Gene Ontology BP GO:0006839 0.0498103902359882 0.056283680181478 3485 3531.63636363636 3575 0.00463411330662986 1803 1.21027181747646 -0.882814782595482 -1 1.40387714162034 3485 4403 3360 3993 3793 1803 3575 3932 3231 4107 3166 3998 M15152 GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 7/21 Gene Ontology BP GO:0071450 0.0512692603411065 0.0578195714752872 3425 3620.54545454545 3575 0.00524919967179087 2620 0.845176327750378 -0.845176327750378 -1 0.97120465510189 3422 4147 4361 3487 3816 2746 2969 4546 4137 3575 2620 3999 M16029 GO_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group. 34/62 Gene Ontology BP GO:0043967 0.0170794757840586 0.0200810347088843 3200 3425.09090909091 3577 0.00156486634885993 1445 0.753130857185451 -0.630724941622506 -1 1.18652281313704 3196 4626 3403 4363 4271 1445 2531 3577 3991 4118 2155 4000 M10393 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM.html A process in which an organism has a negative effect on the functioning of the second organism's cells. 9/82 Gene Ontology BP GO:0044364 0.0106865817211311 0.0127913892578529 3790 3284 3578 0.00107383236270613 1835 1.64231803615526 1.64231803615526 1 2.88599693404277 2130 4515 3578 3786 4067 3305 2189 3194 3789 3736 1835 4001 M10405 GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. 9/30 Gene Ontology BP GO:0001516 0.147859119791321 0.155108425935631 4145 3564.18181818182 3579 0.0158730158730159 2308 2.48628549932511 2.48628549932511 1 1.86794593587947 2959 4144 3579 3372 4145 3449 2308 3820 4167 3737 3526 4002 M14756 GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. 7/14 Gene Ontology BP GO:0046341 0.000584622657025148 0.000788612143105102 4575 3209.63636363636 3579 5.84776516639417e-05 427 2.13011887447393 -1.53288900445695 -1 6.13583756032824 4571 1930 4287 2268 3286 3579 4374 3806 427 2746 4032 4003 M16265 GO_RESPONSE_TO_MISFOLDED_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MISFOLDED_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. 7/17 Gene Ontology BP GO:0051788 0.00760771101511328 0.00920099042541572 2235 3193.63636363636 3579 0.000763388197084777 1497 1.12798705117047 -1.12798705117047 -1 2.13199544616389 2235 3945 4538 4394 4613 1497 2067 2382 4149 3579 1731 4004 M11518 GO_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_CHECKPOINT.html A cell cycle checkpoint that originates from the mitotic or meiotic spindle. 13/31 Gene Ontology BP GO:0031577 0.682206365789624 0.692952123465593 2875 3710.63636363636 3580 0.0989674668232267 2841 0.232529191759204 -0.253529658276384 -1 0.0343835741381622 2872 4512 3243 3928 4364 3045 2841 3444 4616 4372 3580 4005 M13330 GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. 12/61 Gene Ontology BP GO:0006775 0.00544402836662188 0.00666929385388532 4250 3597.72727272727 3580 0.000496140617153143 2531 0.911373029194382 -0.792047402476451 -1 1.84080684076805 4248 3642 2531 4254 3580 2828 3877 3494 4175 3401 3545 4006 M15704 GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. 148/343 Gene Ontology BP GO:0043123 1.26020444403684e-06 2.72525814329905e-06 3350 3582.45454545455 3580 1.14564105991635e-07 2080 1.36860124512027 -1.0761650738886 -1 7.0693488812178 3349 4002 3068 4454 2080 3580 3306 3782 3357 3837 4592 4007 M16959 GO_FRUCTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRUCTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. 7/26 Gene Ontology BP GO:0006000 0.00739051278451353 0.00894996110028595 2430 3132.54545454545 3581 0.000741520730538269 1546 1.32590168415172 -1.32590168415172 -1 2.52085756179355 2427 3878 4641 4485 3619 1546 1984 2089 4210 3581 1998 4008 M12598 GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 13/35 Gene Ontology BP GO:0033146 0.0194983685637248 0.0227636221376349 3585 3342.63636363636 3582 0.00178848688103619 1707 1.15595395324404 -1.42327525591595 -1 1.76272021267944 3582 3961 3090 4346 3799 1707 2717 3406 4237 3939 1985 4009 M13358 GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. 936/2297 Gene Ontology BP GO:0006796 2.52675736618476e-09 3.40132659424763e-08 4175 2690.27272727273 3582 2.52675736905778e-10 81 1.36725490176841 -1.15000422159244 -1 9.47858221728292 4173 886 4059 4310 81 372 4232 3688 2756 3582 1454 4010 M11104 GO_ATP_GENERATION_FROM_ADP http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_GENERATION_FROM_ADP.html The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. 19/54 Gene Ontology BP GO:0006757 0.0839184282471183 0.0891201423493528 3585 3516.81818181818 3583 0.00793650793650794 2461 2.12307293717679 -1.29304160142445 -1 2.06934686147396 3583 4294 2461 3721 4362 4537 2602 2994 2916 3526 3689 4011 M11953 GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. 10/21 Gene Ontology BP GO:0051560 0.0345933268814563 0.039638898497187 4030 3502.27272727273 3583 0.00319541498653359 2318 1.62324877771875 -2.07507927915049 -1 2.11234346771523 4026 2987 2318 3042 3754 4325 3918 3458 3583 2471 4643 4012 M13667 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. 22/49 Gene Ontology BP GO:0061418 0.0839184282471183 0.0891201423493528 2035 3389.81818181818 3583 0.00793650793650794 2035 1.0088499895802 1.13341961142021 1 0.983320118642081 2035 3982 3075 3680 4107 3583 3235 2712 3618 3709 3552 4013 M15146 GO_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. 523/1375 Gene Ontology BP GO:0061024 2.98381790544958e-08 1.37166995396063e-07 4370 3181.90909090909 3583 2.98381794551384e-09 672 1.47460229881715 -1.19534108016418 -1 9.39382016015216 4369 3568 4360 3750 941 672 4426 4571 2367 3583 2394 4014 M11809 GO_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 19/55 Gene Ontology BP GO:0035456 1.67545372015336e-06 3.48683622710536e-06 4270 3267.63636363636 3584 1.52314090557254e-07 1154 0.959911651499947 -0.927687341573645 -1 4.8629474746973 4267 1154 2851 2168 2156 3826 4461 4113 3584 3022 4342 4015 M14719 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. 6/27 Gene Ontology BP GO:2000136 0.011223729856289 0.0134135849994209 4490 3424 3584 0.00112808235694674 1922 1.41100499773511 -0.964258822814558 -1 2.45250035311922 4490 3254 4281 2295 3652 3584 4359 1922 2702 2547 4578 4016 M13745 GO_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_POLARITY.html The maintenance of established anisotropic intracellular organization or cell growth patterns. 3/17 Gene Ontology BP GO:0030011 0.0765897756730953 0.0843068583333764 3585 3460.63636363636 3585 0.00793650793650794 2030 1.00960302349912 1.00960302349912 1 1.00665211782292 3939 2030 4126 2475 3982 4355 4205 2932 3581 2857 3585 4017 M15712 GO_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that modulates the frequency, rate, or extent of receptor recycling. 11/26 Gene Ontology BP GO:0001919 0.108331227156513 0.114522287724884 3045 3402.09090909091 3585 0.0103695476783888 2136 0.644735808344599 -0.731183831608206 -1 0.563236975430559 3043 3585 2764 3744 3886 2502 2136 4198 4319 4585 2661 4018 M13590 GO_SULFUR_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSPORT.html The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/34 Gene Ontology BP GO:0072348 0.00544219578359999 0.0066688083988532 3765 3534.63636363636 3586 0.000545556977584836 2799 1.10659725086921 -0.665509054967467 -1 2.23515658168527 4065 3763 4099 3577 3586 2883 2799 2900 3882 3562 3765 4019 M11887 GO_PHAGOLYSOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOLYSOSOME_ASSEMBLY.html The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. 13/19 Gene Ontology BP GO:0001845 0.0839184282471183 0.0891201423493528 3310 3521.54545454545 3587 0.00793650793650794 2050 1.21330023461828 -0.695674664209628 -1 1.18259660470695 3310 3896 2689 4530 4084 3587 2050 3249 3524 3936 3882 4020 M11667 GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 227/602 Gene Ontology BP GO:0045088 3.33313292203936e-08 1.469616730815e-07 3840 3227.54545454545 3588 3.03012088412577e-09 946 1.42158298212619 -1.19038905965673 -1 9.01653758449621 3839 4153 2925 4545 946 1256 3956 4603 3215 3588 2477 4021 M13069 GO_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JNK_CASCADE.html An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 39/112 Gene Ontology BP GO:0007254 1.94936108989072e-06 3.96099936120902e-06 4170 3398.45454545455 3589 1.77214801560866e-07 2207 1.25213847818947 -1.0372641437603 -1 6.27901852959751 4170 2650 2787 3639 2207 4149 2736 4429 3589 3102 3925 4022 M16731 GO_REGULATION_OF_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING.html Any process that modulates the frequency, rate or extent of protein targeting. 212/501 Gene Ontology BP GO:1903533 1.7999308902744e-08 9.77436154800475e-08 3945 3184.27272727273 3589 1.63630082272777e-09 705 1.4242256405927 -0.995868219951803 -1 9.2674547494748 3942 4001 2915 3929 705 2041 3887 2967 2787 3589 4264 4023 M12066 GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE.html Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. 5/16 Gene Ontology BP GO:0010889 5.98180802919299e-06 1.08660151328416e-05 3590 3280.18181818182 3590 5.98182413116627e-07 2274 1.48645040582106 1.41730824735867 1 6.84928401285013 3590 2871 3844 2390 2495 3629 3167 4088 3885 2274 3849 4024 M15710 GO_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLATION.html The covalent attachment and further modification of carbohydrate residues to a substrate molecule. 126/292 Gene Ontology BP GO:0070085 1.51587796154101e-08 8.7711799069668e-08 4505 3152.63636363636 3591 1.37807088362358e-09 644 1.18130018613023 -0.990918917219438 -1 7.73830690534238 4501 1510 3076 3620 644 1981 4617 4204 2964 3591 3971 4025 M16841 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 8/24 Gene Ontology BP GO:0060260 0.0126687846155915 0.015059182532051 2785 3619.45454545455 3591 0.00127415936329929 2435 0.604227060652858 -0.380353983170169 -1 1.02203304138449 2782 3591 4624 3123 3668 3525 2435 4139 3936 4638 3353 4026 M13146 GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that modulates I-kappaB kinase/NF-kappaB signaling. 192/420 Gene Ontology BP GO:0043122 1.59009869410546e-07 4.7477995091522e-07 4055 3287.36363636364 3592 1.44554437184853e-08 1482 1.3149210868117 -1.0764465846002 -1 7.71839263949431 4053 3336 2942 3809 1482 2368 3935 3852 3050 3592 3742 4027 M14021 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 29/78 Gene Ontology BP GO:0002066 4.64008764268927e-06 8.59350894495662e-06 4375 3333.09090909091 3593 4.21827039024516e-07 1771 1.92169916936991 1.97221011254533 1 9.03660087000167 3593 4373 2385 2621 2422 4521 3817 3730 1771 3058 4373 4028 M16645 GO_ORGANELLE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_DISASSEMBLY.html The disaggregation of an organelle into its constituent components. 121/263 Gene Ontology BP GO:1903008 6.12293933340014e-06 1.11006666634037e-05 4130 3197.36363636364 3594 5.56632397686465e-07 1329 1.68429826931418 -1.30028584346037 -1 7.74642278919184 4129 4188 1998 4432 2477 1329 3996 3326 2074 3594 3628 4029 M10871 GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. 85/179 Gene Ontology BP GO:0035567 0.0246525634528473 0.0285654734493561 3630 3491.63636363636 3595 0.00226665690693985 2416 1.44542512767101 1.57099807197326 1 2.07184182902686 3630 3046 3127 3068 3722 2926 4105 4419 2416 3595 4354 4030 M10482 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. 9/23 Gene Ontology BP GO:0045603 3.44934957129332e-05 5.44739117670574e-05 4590 3343.27272727273 3596 3.4494031135191e-06 1642 1.92787173260679 -1.97514534666173 -1 7.63036400477764 4588 2637 3596 2122 2854 4314 3724 4359 2871 1642 4069 4031 M15420 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. 7/16 Gene Ontology BP GO:1903203 0.0765897756730953 0.0843068583333764 3345 3751.45454545455 3596 0.00793650793650794 3170 1.42956389771125 -0.678657906030477 -1 1.4253855994085 3343 3996 4402 3423 4017 4335 3916 3170 3596 3576 3492 4032 M16102 GO_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that modulates the frequency, rate or extent of muscle adaptation. 48/102 Gene Ontology BP GO:0043502 0.0839184282471183 0.0891201423493528 2540 3439.09090909091 3596 0.00793650793650794 1952 1.60697590608598 -1.98118735919247 -1 1.56631003309974 2537 4328 2307 4416 4228 3250 1952 3538 3844 3596 3834 4033 M10523 GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. 8/19 Gene Ontology BP GO:0048715 2.39094864039607e-05 3.88017285472176e-05 3520 3473 3598 2.39097436564492e-06 2257 0.707510319611326 -0.687272028560328 -1 2.89703412502268 3520 2488 3598 2257 2779 4228 3017 3880 3944 4318 4174 4034 M10265 GO_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXPORT_FROM_NUCLEUS.html The directed movement of a protein from the nucleus into the cytoplasm. 23/55 Gene Ontology BP GO:0006611 0.161385165508919 0.168954075187804 3120 3658 3600 0.0158730158730159 2878 1.05987109505814 -1.23291286572581 -1 0.759747868564011 3118 4447 3266 4219 4336 2945 3600 2878 4163 3984 3282 4035 M12896 GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. 122/332 Gene Ontology BP GO:0043903 4.40768789950842e-07 1.0955511197761e-06 3885 3171.72727272727 3602 4.00698980235137e-08 1258 1.33040999450164 -1.27139120481799 -1 7.36084472110632 3883 3857 2748 4391 1794 1258 4293 3609 3602 3264 2190 4036 M10132 GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION.html Any process that set the alignment of spindle relative to other cellular structures. 18/33 Gene Ontology BP GO:0051294 0.00669610725534794 0.0081323635852944 4270 3618.36363636364 3603 0.000610597760773234 2581 1.81549128823259 -1.42131362262174 -1 3.52179864945886 4266 3342 2581 2791 3603 4013 4120 4476 3502 2983 4125 4037 M14440 GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. 6/14 Gene Ontology BP GO:0006851 0.00144751307452701 0.00187574747558719 3605 3417.90909090909 3603 0.000144845682217579 1453 1.43627254619114 -1.43627254619114 -1 3.63549326432617 3603 3782 4237 3806 3950 2950 3202 1453 4152 3447 3015 4038 M13543 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 7/12 Gene Ontology BP GO:1902222 2.71222983949232e-05 4.36041660137218e-05 3390 3643.18181818182 3604 2.71226294291911e-06 2734 1.03742048211165 -1.05009187337811 -1 4.19911185036666 4254 3162 4094 3386 2808 3388 4434 4539 3604 2734 3672 4039 M16112 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 7/12 Gene Ontology BP GO:1902221 2.71222983949232e-05 4.36041660137218e-05 3390 3684.81818181818 3605 2.71226294291911e-06 2757 1.03742048211165 -1.05009187337811 -1 4.19911185036666 4255 3163 4510 3387 2809 3389 4435 4550 3605 2757 3673 4040 M16388 GO_L_PHENYLALANINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. 7/12 Gene Ontology BP GO:0006559 2.71222983949232e-05 4.36041660137218e-05 3390 3690.09090909091 3606 2.71226294291911e-06 2760 1.03742048211165 -1.05009187337811 -1 4.19911185036666 4256 3164 4556 3388 2810 3390 4436 4551 3606 2760 3674 4041 M12907 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. 8/16 Gene Ontology BP GO:0070198 0.103411279069307 0.109370972373301 3365 3700.81818181818 3607 0.0108564415298231 2536 0.381397825521973 -0.35425617048029 -1 0.340263006541283 3365 4277 3979 3607 4592 2702 3370 3357 4484 4440 2536 4042 M15787 GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. 32/77 Gene Ontology BP GO:0000245 0.042157416491789 0.0479277386805525 2595 3448.45454545455 3607 0.00390796507469352 1725 0.989375171345119 -0.989375171345119 -1 1.21174393757575 2595 4376 3396 4073 4518 1725 2824 3607 4393 4176 2250 4043 M11762 GO_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_PROCESS.html Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. 289/703 Gene Ontology BP GO:0007017 8.87937400661169e-07 2.0022794323797e-06 3600 3510.81818181818 3608 8.07216144581753e-08 1992 1.40578961780981 -1.07355524083929 -1 7.43614985431265 3597 4355 3020 3608 1992 2772 3657 3938 3098 4068 4514 4044 M11360 GO_PROTEIN_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEALKYLATION.html The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 15/32 Gene Ontology BP GO:0008214 0.247701038486992 0.256828030749242 3370 3723.45454545455 3609 0.0255427989631006 2395 0.449273527812808 -0.449273527812808 -1 0.246203801790847 3367 4344 3336 4284 4410 2395 3609 3565 4368 4363 2917 4045 M13827 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. 4/17 Gene Ontology BP GO:0001956 0.000199088542775196 0.000283027588519668 4140 3319.45454545455 3609 1.9910638133603e-05 1269 1.12118365208795 1.12118365208795 1 3.69275457605291 3609 1269 4139 2569 3155 4185 4140 3814 2544 3120 3970 4046 M16750 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. 20/47 Gene Ontology BP GO:0002483 0.0839184282471183 0.0891201423493528 3630 3349.18181818182 3609 0.00793650793650794 2324 1.73197026583201 -0.985287520948843 -1 1.68814132160457 3628 3772 2324 2523 3879 2817 3709 4184 3227 3169 3609 4047 M13741 GO_PROTEIN_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMETHYLATION.html The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 15/32 Gene Ontology BP GO:0006482 0.247701038486992 0.256828030749242 3370 3734.90909090909 3610 0.0255427989631006 2396 0.449273527812808 -0.449273527812808 -1 0.246203801790847 3368 4345 3337 4285 4411 2396 3610 3557 4369 4488 2918 4048 M11243 GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of vacuolar transport. 13/23 Gene Ontology BP GO:1903337 0.136241683590942 0.143342428486913 2480 3349.63636363636 3611 0.013226503126644 2120 0.83462377731287 -0.904385440534073 -1 0.653595909548582 2479 3611 2703 3664 3916 3854 2120 3266 4248 3933 3052 4049 M15790 GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT.html The progression of the atrioventricular valve over time, from its formation to the mature structure. 10/30 Gene Ontology BP GO:0003171 0.0839184282471183 0.0891201423493528 2290 3284.27272727273 3611 0.00793650793650794 2286 1.18296196308442 1.18296196308442 1 1.15302606472827 2286 3828 2587 3894 4186 2671 2379 3611 3860 3823 3002 4050 M10626 GO_RESPONSE_TO_IMMOBILIZATION_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IMMOBILIZATION_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. 7/28 Gene Ontology BP GO:0035902 0.00814093717325338 0.00982286156325765 3875 3481 3612 0.000817091554149704 1959 1.34555653617416 -1.09318666275909 -1 2.50774447559252 3871 3220 3612 2581 3628 4572 4377 3048 3113 1959 4310 4051 M11252 GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. 14/35 Gene Ontology BP GO:0010833 0.326761018408151 0.336546452632884 3215 3718.27272727273 3612 0.0353294438224097 2889 0.564087932140356 -0.564087932140356 -1 0.247648327160306 3212 4270 3301 3612 4038 2889 3589 3669 4468 4355 3498 4052 M16096 GO_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING.html The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 204/464 Gene Ontology BP GO:0008380 0.0839184282471183 0.0891201423493528 2240 3600.18181818182 3612 0.00793650793650794 2028 0.974354732800209 -0.80177795989157 -1 0.949697788887766 2240 4541 3518 4520 4621 2028 3339 3612 4080 4293 2810 4053 M11985 GO_SPERM_CAPACITATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_CAPACITATION.html A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. 8/27 Gene Ontology BP GO:0048240 1.14327619156181e-06 2.50152278860578e-06 4415 3445 3614 1.14327677974843e-07 1870 1.3493683652894 -1.52780862935745 -1 7.01660303720199 4412 2895 3838 3505 2078 3909 4576 1870 3614 2916 4282 4054 M15405 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. 10/38 Gene Ontology BP GO:1901984 0.00162327323250809 0.00209473530253893 3845 3709.63636363636 3614 0.00014767929143278 2468 0.624728167635032 -0.592603069129558 -1 1.55350247404961 3845 3614 3129 3243 3409 4402 2468 3352 4233 4570 4541 4055 M13030 GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 3/21 Gene Ontology BP GO:0042423 0.020255944848934 0.0236124408570426 3620 3408.27272727273 3616 0.00204429853367206 2333 1.47606136589554 -1.47606136589554 -1 2.22906873873996 3616 3228 3997 3090 3709 3657 3775 3922 3311 2853 2333 4056 M12625 GO_COBALAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COBALAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. 9/42 Gene Ontology BP GO:0009235 0.0072895452392798 0.00882999179388889 4000 3314.72727272727 3617 0.000731356808162648 1136 1.63098795369908 1.61135595777192 1 3.10977308524976 3997 2834 3939 2465 3617 4534 4037 3379 2001 1136 4523 4057 M13444 GO_MALE_MEIOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. 18/155 Gene Ontology BP GO:0007140 0.0523849797656459 0.0590204952807313 2700 3688.27272727273 3617 0.00487959734914921 1678 0.323288083280892 0.364312882439156 1 0.36881576313039 2696 4637 2977 4515 4574 3396 1678 3376 4635 4470 3617 4058 M16878 GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. 3/21 Gene Ontology BP GO:0009713 0.020255944848934 0.0236124408570426 3620 3467.36363636364 3617 0.00204429853367206 2334 1.47606136589554 -1.47606136589554 -1 2.22906873873996 3617 3229 4628 3091 3710 3658 3776 3921 3312 2865 2334 4059 M11710 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. 19/53 Gene Ontology BP GO:0036092 0.036500565835262 0.0416700583164794 3620 3535.36363636364 3618 0.00337460032106545 2556 1.4735943701642 -1.52342811893867 -1 1.88791086598344 3618 2951 2556 3470 3761 4105 3054 4375 3669 3021 4309 4060 M15972 GO_MATERNAL_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PLACENTA_DEVELOPMENT.html Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 16/41 Gene Ontology BP GO:0001893 0.00807821297488234 0.00974971220233395 3255 3224.54545454545 3618 0.000737093533931939 1512 1.69045875072638 1.42701291477884 1 3.15564059567994 3255 3796 1512 4030 3618 3771 2345 3260 3954 1689 4240 4061 M15922 GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX.html The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. 6/16 Gene Ontology BP GO:0030150 0.0195586626787122 0.0228282732069535 2695 3407.09090909091 3619 0.00197329693320004 2162 0.595484657682265 -0.595484657682265 -1 0.907376725858861 2695 3619 4480 3890 3706 2162 2921 2575 4428 4597 2405 4062 M12872 GO_PROTEIN_O_LINKED_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_FUCOSYLATION.html The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. 6/19 Gene Ontology BP GO:0036066 1.85336733695271e-05 3.06561615442516e-05 3620 3463.45454545455 3620 1.85338279450133e-06 1726 1.37803380161761 1.25897163281909 1 5.77352078634751 3620 2992 3973 4083 2734 4158 3529 4440 2614 1726 4229 4063 M10698 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 8/14 Gene Ontology BP GO:0034244 0.000217112109486804 0.00030733278181318 1865 2829.90909090909 3621 2.17133324354637e-05 684 0.988255275015897 -0.988255275015897 -1 3.2221156593475 1861 4242 3621 4122 4641 857 684 1294 4585 4327 895 4064 M13503 GO_MEGAKARYOCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. 10/21 Gene Ontology BP GO:0035855 2.9568585541966e-05 4.72914029181358e-05 4280 3640 3621 2.6880893599185e-06 2805 1.02429993157394 -0.730668743612887 -1 4.11248423645755 4276 3128 2860 3003 2805 4319 4260 3621 3510 3810 4448 4065 M16839 GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-12 production. 41/124 Gene Ontology BP GO:0032655 0.0839184282471183 0.0891201423493528 3975 3439.45454545455 3622 0.00793650793650794 2339 1.48183395063618 -1.49158956906615 -1 1.44433488390549 3975 3769 2339 3749 4226 2779 4266 3622 3600 2512 2997 4066 M11779 GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 17/63 Gene Ontology BP GO:0045979 0.0839184282471183 0.0891201423493528 4605 3562.09090909091 3623 0.00793650793650794 2418 1.34557823468877 -1.27199946731547 -1 1.31152721583351 4604 3152 2418 2953 4210 3332 4421 3623 3703 2827 3940 4067 M11823 GO_NAD_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 32/75 Gene Ontology BP GO:0019674 0.000487062008208035 0.000664149457888373 3795 3011.90909090909 3623 4.4288170289772e-05 676 1.27823668428882 -1.2346310959636 -1 3.77049145597929 2327 3792 2963 4444 3682 676 2125 4413 3795 3623 1291 4068 M10719 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. 7/15 Gene Ontology BP GO:0002583 0.0161832127748811 0.0190707251050185 3900 3174 3625 0.00163022884201566 336 2.555945411184 -1.15754306165215 -1 4.07996477266075 3898 3967 3625 2029 3688 4494 3254 2742 336 2716 4165 4069 M12009 GO_DECIDUALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DECIDUALIZATION.html The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. 12/25 Gene Ontology BP GO:0046697 0.00858696809904592 0.010350283718554 3660 3272.63636363636 3625 0.000783697161073739 1251 1.76902274425912 1.47899744609106 1 3.25966889893471 3657 3403 1251 4176 3625 4233 2873 2664 3951 1597 4569 4070 M16252 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. 59/208 Gene Ontology BP GO:1902106 0.0150200757677819 0.0177676972712895 4110 3587.81818181818 3625 0.0013748739488824 2403 1.55925441044617 -1.63756497597627 -1 2.53346941299403 4106 3859 2403 4557 3675 2776 4475 3625 3543 3105 3342 4071 M15333 GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. 7/14 Gene Ontology BP GO:0006047 0.0765897756730953 0.0843068583333764 4020 3629.54545454545 3626 0.00793650793650794 2642 1.04364643461097 -1.05244077893124 -1 1.04059603244748 4016 2642 4390 4008 4326 3626 4593 2848 3300 2750 3426 4072 M13414 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS.html Splicing of RNA via a series of two transesterification reactions. 157/364 Gene Ontology BP GO:0000375 0.134828747673907 0.141952352709739 2240 3577.45454545455 3627 0.0130798699264961 2143 0.970391820157677 -0.818389125604356 -1 0.763728453405055 2237 4480 3510 4080 4489 2143 3251 3627 4290 4285 2960 4073 M15525 GO_CARDIAC_CHAMBER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_FORMATION.html The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. 6/19 Gene Ontology BP GO:0003207 2.83289423568639e-07 7.57232466107766e-07 3905 2721.36363636364 3629 2.83289459682449e-08 335 1.88387462949863 -1.0661739347796 -1 10.7035353239854 3903 985 4418 785 1694 4223 4273 4606 335 1084 3629 4074 M11924 GO_NUCLEAR_PORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. 7/17 Gene Ontology BP GO:0006999 0.275742742869669 0.285011922338351 3210 3698.45454545455 3632 0.0317460317460317 3078 0.763325331403914 -0.763325331403914 -1 0.386263993260086 3206 3997 3824 3432 4182 3078 3140 3632 4241 4382 3569 4075 M13274 GO_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. 8/19 Gene Ontology BP GO:0046931 0.147859119791321 0.155108425935631 3635 3715 3633 0.0158730158730159 2982 0.763325331403914 -0.763325331403914 -1 0.573486069746812 3633 3944 4042 3370 4049 2982 3228 3437 4164 4459 3557 4076 M10374 GO_REGULATION_OF_ICOSANOID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ICOSANOID_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. 12/42 Gene Ontology BP GO:0032303 0.00300009070263306 0.00376674449224589 3300 3683.54545454545 3634 0.000273108153346021 2788 1.05428911587186 -0.920045551182376 -1 2.37228851329085 3299 3963 2788 4205 3491 4261 3634 3025 4376 3391 4086 4077 M11854 GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. 59/129 Gene Ontology BP GO:1901800 7.49333412121181e-09 5.86332115310401e-08 4415 3190.09090909091 3634 6.81212195157689e-10 367 1.06004985601493 -1.05130912355874 -1 7.11615190489187 4414 2941 3067 4501 367 2209 3649 4156 3634 3783 2370 4078 M11752 GO_PURINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. 9/17 Gene Ontology BP GO:0043101 9.08246921451604e-05 0.000134256302333645 3460 3507.90909090909 3635 9.08284044648196e-06 2191 0.948028541999648 0.657483850365247 1 3.40747912417896 3459 2191 3800 4010 3030 4030 3068 3871 3635 3071 4422 4079 M12137 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 15/30 Gene Ontology BP GO:0051985 0.785385951987544 0.794108661820159 3050 3792.63636363636 3635 0.130555930170361 2985 0.270258297111999 -0.278045677830752 -1 0.0251168853894331 3046 4384 3201 4367 4457 3179 2985 3465 4605 4395 3635 4080 M13355 GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 27/57 Gene Ontology BP GO:0090199 4.08854145989223e-06 7.66374565937813e-06 3905 3237.81818181818 3636 3.71686278015606e-07 1937 1.62673446192774 -0.892669661332478 -1 7.72465138675059 3904 3819 2545 3014 2393 3636 3881 2227 1937 3677 4583 4081 M14247 GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 9/27 Gene Ontology BP GO:0071360 0.00938996130001927 0.0112859410603131 3875 3633.18181818182 3636 0.000942987599501264 2781 1.01496770800622 -0.897027302736431 -1 1.83480688361142 3874 3906 4213 3604 3636 2781 3514 3328 4008 3753 3348 4082 M16674 GO_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_ASSEMBLY.html The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 6/22 Gene Ontology BP GO:0046847 0.000105283997345265 0.000154498609252233 4315 3668.18181818182 3637 1.05288985801941e-05 2555 1.49221902074005 -1.6258720361239 -1 5.27897057194794 4312 3498 4602 2904 3053 3666 4440 3637 3220 2555 4463 4083 M11089 GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 175/351 Gene Ontology BP GO:0045732 0.000264173511742853 0.000370113945389881 3040 3324.72727272727 3639 2.40186580666474e-05 572 1.06037781765899 -0.895572945923819 -1 3.37780503359966 3036 4215 3439 4584 4632 572 2928 3639 3665 4189 1673 4084 M11241 GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that activates or increases the frequency, rate or extent of viral release from host cell. 8/18 Gene Ontology BP GO:1902188 0.0130630141500256 0.0155079454611528 2210 3132.27272727273 3639 0.00131404445755092 1412 0.670671107040231 -0.670671107040231 -1 1.12648191534886 2208 3908 3715 4120 3936 1412 2613 1949 4594 3639 2361 4085 M10088 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR.html Any process that modulates the frequency, rate or extent of double-strand break repair. 17/48 Gene Ontology BP GO:2000779 0.05860630241308 0.0658540808576793 3555 3678.72727272727 3640 0.00547530510045759 2753 0.654206010916949 -0.645723591856543 -1 0.717442133133618 3554 3640 2986 3671 3822 2753 3408 4524 4388 4302 3418 4086 M13353 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION.html Any recombinational process that contributes to the maintenance of proper telomeric length. 18/33 Gene Ontology BP GO:0000722 0.618223374046146 0.629614197345088 2325 3680.90909090909 3642 0.0838160764532755 2323 0.394893287541691 -0.394893287541691 -1 0.0736516909931642 2323 4505 3307 3762 4377 2885 3174 3642 4591 4462 3462 4087 M14052 GO_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G2_M_PHASE_TRANSITION.html The cell cycle process by which a cell in G2 phase commits to M phase. 80/243 Gene Ontology BP GO:0044839 0.0839184282471183 0.0891201423493528 2225 3499.63636363636 3642 0.00793650793650794 1907 1.54208720053433 2.04462639362839 1 1.50306338242823 2221 4617 3247 3850 4552 3808 1907 3383 3642 4123 3146 4088 M10053 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. 11/25 Gene Ontology BP GO:1900225 0.00101625684682395 0.001334034645124 4065 3702.36363636364 3643 9.24296904707502e-05 2911 0.570984383192287 -0.51198739246544 -1 1.5237226360474 3453 3350 2911 3676 3353 4064 3637 3643 4061 4301 4277 4089 M12031 GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that activates or increases the frequency, rate or extent of translational initiation. 13/25 Gene Ontology BP GO:0045948 0.00933753488114723 0.0112258349179613 3905 3729.72727272727 3643 0.000852491236636472 2961 1.25231687304985 -1.23122498456277 -1 2.2665705777876 3901 3799 2961 4398 3631 3323 4562 3374 3925 3510 3643 4090 M16432 GO_TEMPERATURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TEMPERATURE_HOMEOSTASIS.html A homeostatic process in which an organism modulates its internal body temperature. 10/35 Gene Ontology BP GO:0001659 0.0839184282471183 0.0891201423493528 4470 3556.18181818182 3643 0.00793650793650794 2585 1.39815078862164 -1.12682446711275 -1 1.3627693838693 4470 3096 2585 3643 4282 3004 3674 2788 3835 3219 4522 4091 M12893 GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT.html The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 11/44 Gene Ontology BP GO:0015697 0.00193832285539658 0.00247992091970414 3815 3578.18181818182 3644 0.000176366612322412 2570 1.08874123191088 0.972617417385893 1 2.63326895381487 3811 2597 2570 3644 3434 3737 4088 4596 3990 3319 3574 4092 M14408 GO_CELLULAR_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 23/62 Gene Ontology BP GO:0071359 0.000611169348819362 0.000822033397036008 3935 3544.45454545455 3644 5.55762909386305e-05 2611 0.977248113481483 -0.815455604727091 -1 2.79862481425927 3935 4339 3216 3021 3281 2611 3718 3644 4064 3986 3174 4093 M14785 GO_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-8 secretion. 10/21 Gene Ontology BP GO:2000482 0.000341535650065942 0.000473640986635654 3830 3498.45454545455 3644 3.10535166158559e-05 1764 1.81646309845822 -1.504828026715 -1 5.60568473673023 3828 3644 1764 3578 3215 4449 3138 4255 3855 2488 4269 4094 M10223 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein. 3/14 Gene Ontology BP GO:0042511 0.0336347311521788 0.0385881039633225 3540 3743.27272727273 3645 0.00341549300237432 2747 0.764110799700849 -0.942779340480439 -1 1.00261802925342 3848 2747 3555 3406 3762 3540 4471 3645 4353 4310 3539 4095 M10592 GO_MYELOID_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. 28/60 Gene Ontology BP GO:0061515 2.64434320735431e-07 7.17993304780471e-07 3645 3281.27272727273 3645 2.40394865927054e-08 1643 1.24033792314955 1.38595768873146 1 7.07378488750005 2526 3842 2845 4133 1643 4108 3787 2217 3645 3704 3644 4096 M12528 GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING.html Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. 8/18 Gene Ontology BP GO:0006349 0.00661114492482803 0.00803338023710457 2840 3119.18181818182 3646 0.000663089593048328 1679 1.20610785032769 -1.20610785032769 -1 2.34563456694518 2837 3805 3925 4337 4087 1679 2118 1793 4154 3646 1930 4097 M16898 GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS.html A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. 24/66 Gene Ontology BP GO:0061640 0.0162926482892337 0.019194815023322 4575 3480.27272727273 3646 0.00149223396114094 1855 2.18070722086334 -1.00983215984377 -1 3.47528357573878 4575 4632 1855 3646 3681 3084 4093 2919 2203 3055 4540 4098 M12559 GO_ATRIAL_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_MORPHOGENESIS.html The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. 8/20 Gene Ontology BP GO:0060413 0.0765897756730953 0.0843068583333764 2710 3590.45454545455 3647 0.00793650793650794 2707 1.46182390985512 1.46182390985512 1 1.4575513272905 2707 4178 3930 3819 4618 3146 2794 3440 3727 3647 3489 4099 M15324 GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 92/255 Gene Ontology BP GO:0043901 1.25493742551572e-06 2.71639835275968e-06 4565 3393 3647 1.14085285578669e-07 2077 1.32762741338864 -1.19379561548525 -1 6.85944618227989 4563 3787 2638 3793 2077 2257 3925 4380 3439 2817 3647 4100 M10851 GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a sphingolipid. 5/14 Gene Ontology BP GO:0090520 0.249127481948728 0.25819171845713 2850 3528.18181818182 3648 0.028245364617827 2733 0.980424834300267 -0.980424834300267 -1 0.535184115958299 2850 4029 3648 3656 4010 2733 2880 2998 4323 4333 3350 4101 M15831 GO_PEPTIDYL_ASPARAGINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ASPARAGINE_MODIFICATION.html The modification of peptidyl-asparagine. 18/40 Gene Ontology BP GO:0018196 0.0839184282471183 0.0891201423493528 3650 3579.36363636364 3648 0.00793650793650794 1750 1.05968375731942 1.39800977514386 1 1.03286750170647 3648 3693 3195 4324 4485 4091 3186 3495 1750 4047 3459 4102 M10881 GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. 8/20 Gene Ontology BP GO:0000380 0.203987094842991 0.212882014240505 2855 3691.81818181818 3651 0.0225557168439971 2202 0.137259109019241 0.147014308389994 1 0.0856029505790429 2852 4312 3651 4061 4451 3519 2202 3062 4545 4336 3619 4103 M13938 GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. 11/18 Gene Ontology BP GO:0007004 0.215550160094111 0.22429390258112 3285 3659.81818181818 3651 0.0218284748223263 2778 0.564087932140356 -0.564087932140356 -1 0.339924538256553 3284 3942 3279 3438 3973 2778 3733 3651 4321 4496 3363 4104 M10884 GO_SNORNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. 5/12 Gene Ontology BP GO:0016074 0.717772719174366 0.728122948465497 3310 3774.63636363636 3652 0.118829601807858 2942 0.474577719534452 -0.474577719534452 -1 0.0607028907652885 3309 4247 3652 4035 4213 3112 2942 3626 4470 4337 3578 4105 M11000 GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION.html The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. 14/26 Gene Ontology BP GO:0006271 0.857739432639484 0.865569264452321 3110 3824 3653 0.16245589710739 3109 0.470198936567835 -0.470198936567835 -1 0.0273654401327247 3109 4305 3258 4145 4463 3238 3415 3570 4564 4344 3653 4106 M13097 GO_PROTEIN_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_STABILIZATION.html Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. 83/182 Gene Ontology BP GO:0050821 0.00304546336857674 0.00382267813471257 3825 3237.72727272727 3653 0.000277244308791922 979 1.29372156562126 -1.48860440651726 -1 2.90335521117126 3821 3653 2983 3725 4274 979 4360 2989 3526 3833 1472 4107 M10795 GO_MALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. 6/30 Gene Ontology BP GO:0030539 0.139555884358779 0.146729613015809 3955 3646.54545454545 3654 0.0149182644012132 2523 1.76720671952787 -1.76720671952787 -1 1.36726524861104 3951 3620 3637 3642 4335 3723 3938 2656 4433 2523 3654 4108 M11870 GO_GABAERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABAERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. 4/21 Gene Ontology BP GO:0097154 0.347420489008521 0.357348987697511 3660 3663.63636363636 3656 0.0417841652263144 3073 0.83521893693098 -0.659029050744653 -1 0.346486890654341 3656 3596 3819 3178 4059 3192 3212 3721 4414 4380 3073 4109 M15471 GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 5/14 Gene Ontology BP GO:0003376 0.249127481948728 0.25819171845713 2855 3620.90909090909 3657 0.028245364617827 2734 0.980424834300267 -0.980424834300267 -1 0.535184115958299 2851 4030 4412 3657 4011 2734 2881 3005 4324 4574 3351 4110 M13248 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 20/47 Gene Ontology BP GO:0071157 6.66802555416748e-06 1.19673918237339e-05 3670 3416.09090909091 3661 6.06185978591814e-07 2155 0.709682999520693 -0.7015619657197 -1 3.24246404749155 3666 4043 3175 4536 2500 2155 2658 3661 4165 4457 2561 4111 M14662 GO_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_ANION_GENERATION.html The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. 6/16 Gene Ontology BP GO:0042554 0.0118523132737724 0.014124817897876 3820 3428.45454545455 3661 0.00119160067074994 1733 1.96919506098012 1.8189723056467 1 3.38168854630172 3817 2938 4268 2289 3661 4323 2832 4097 3548 1733 4207 4112 M15584 GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. 10/16 Gene Ontology BP GO:0070234 0.000674194326681633 0.000902359255918945 3975 3298 3661 6.13091839585568e-05 961 3.72113223684694 -3.03901622561265 -1 10.5166496945706 3974 4272 1505 2802 3296 4401 3661 4348 961 2497 4561 4113 M16594 GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process that decreases the concentration of calcium ions in the cytosol. 8/20 Gene Ontology BP GO:0051481 0.049025400311752 0.0554236507541915 2740 3498.36363636364 3663 0.00501417940650607 1687 1.6963348236266 1.6963348236266 1 1.97822514899299 2740 3758 4589 3655 3900 3157 1687 3361 4144 3663 3828 4114 M15237 GO_MITOCHONDRIAL_GENOME_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_GENOME_MAINTENANCE.html The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. 19/31 Gene Ontology BP GO:0000002 1.75182782937203e-05 2.91427323961817e-05 4225 3458.18181818182 3664 1.59258343552397e-06 2592 1.47686154358374 -0.867911078901155 -1 6.21772031669945 4222 3664 2813 4032 2707 3029 3710 3929 2592 3881 3461 4115 M13491 GO_REGULATION_OF_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_CYCLE.html Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. 27/54 Gene Ontology BP GO:0046605 0.0663515230454698 0.0742516561822407 3320 3768.27272727273 3665 0.00622195159310691 2697 0.570454218810989 -0.49227174192176 -1 0.597993902160766 3316 4500 3165 4371 3837 2697 3665 3567 4521 4476 3336 4116 M16685 GO_GLYCOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. 9/26 Gene Ontology BP GO:0016137 0.0125274756473763 0.0149064760201866 3680 3702.90909090909 3666 0.00125986630466895 2138 0.946983420925608 -0.946983420925608 -1 1.60568689763299 3678 3412 4605 3641 3666 3087 4382 2138 4179 4635 3309 4117 M12156 GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. 4/13 Gene Ontology BP GO:2000105 0.117003095715941 0.123408762700843 2850 3546.72727272727 3667 0.0123662599639144 2230 0.41394676498631 -0.41394676498631 -1 0.349149902594641 2849 4062 3858 3667 4611 2230 2600 3593 4562 4398 2584 4118 M15861 GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an androgen binding to its receptor. 24/55 Gene Ontology BP GO:0030521 0.0141029314868372 0.0166997987486318 3925 3351.90909090909 3670 0.00129037791076577 2049 2.16631221422882 2.62911392794665 1 3.57394743591192 3925 4194 2268 2548 3670 3736 4353 2556 2049 3053 4519 4119 M14809 GO_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 77/173 Gene Ontology BP GO:0071156 5.22700408024688e-08 2.02704238929598e-07 3190 3288.27272727273 3671 4.75182200403261e-09 1097 1.3101911240574 1.57819632104065 1 8.14017065676786 3187 4256 2726 4059 1097 3671 3994 2375 2862 4064 3880 4120 M10140 GO_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 55/151 Gene Ontology BP GO:0016052 0.0839184282471183 0.0891201423493528 3885 3547.45454545455 3672 0.00793650793650794 2384 1.40251711247145 -1.2479330821903 -1 1.36702521478624 3884 3789 2653 4384 4069 2384 4380 3672 3172 3383 3252 4121 M11027 GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION.html The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 9/25 Gene Ontology BP GO:0021694 0.0765897756730953 0.0843068583333764 4355 3648.36363636364 3672 0.00793650793650794 1645 1.42236697853069 -1.25933949291975 -1 1.41820971420057 4351 3488 3672 3706 4432 4247 4401 3571 3420 1645 3199 4122 M15874 GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 21/58 Gene Ontology BP GO:0072523 3.64640255490604e-07 9.38062286621005e-07 4450 3469.27272727273 3672 3.31491196298295e-08 1734 1.40354762745005 -0.94659735921762 -1 7.85331174081387 4447 3983 2630 4011 1734 3397 4622 2870 2861 3672 3935 4123 M12650 GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. 8/11 Gene Ontology BP GO:0070129 0.000970863028893739 0.00127914785560546 1950 2822.27272727273 3673 9.71287448643549e-05 1003 0.598816902609437 -0.598816902609437 -1 1.60813857107002 1948 3673 3945 3959 4269 1003 1135 1368 3705 4427 1613 4124 M15065 GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 12/32 Gene Ontology BP GO:0050995 5.72320040702367e-06 1.04411864400043e-05 3675 3319.18181818182 3675 5.20292299611333e-07 1914 1.07957720940178 1.11122703123948 1 4.99184606025124 3675 1914 2261 3724 2465 4418 3262 4268 3893 2810 3821 4125 M14058 GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of ATP metabolic process. 17/63 Gene Ontology BP GO:1903580 0.0839184282471183 0.0891201423493528 4605 3568.27272727273 3676 0.00793650793650794 2419 1.34557823468877 -1.27199946731547 -1 1.31152721583351 4605 3153 2419 2954 4211 3333 4422 3676 3704 2833 3941 4126 M16240 GO_PEPTIDYL_LYSINE_DIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_DIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. 7/15 Gene Ontology BP GO:0018027 0.111248524098479 0.117579535030557 4330 3629.09090909091 3676 0.0117244898908821 2405 0.38372333031837 -0.406683255107724 -1 0.331142622976659 3242 3676 4532 4329 4413 2405 2810 3009 4326 4608 2570 4127 M16259 GO_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. 928/2309 Gene Ontology BP GO:0009056 4.62031212279442e-09 4.5728211272053e-08 3680 3055.18181818182 3676 4.6203121324007e-10 239 1.54738127422162 -1.18188744507146 -1 10.5426947177811 3676 4354 4536 4585 239 243 3669 4181 2394 4080 1650 4128 M16408 GO_REGULATION_OF_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROPTOTIC_PROCESS.html Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. 10/18 Gene Ontology BP GO:0060544 0.000813581097962053 0.00108112679961014 4055 3398.63636363636 3676 7.3989283992458e-05 1566 1.08148669992805 -0.98768143789197 -1 2.97769015900638 4055 1566 2698 2686 3327 4562 4080 4171 3676 2502 4062 4129 M12021 GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition. 38/93 Gene Ontology BP GO:1902749 0.0839184282471183 0.0891201423493528 3680 3688.36363636364 3678 0.00793650793650794 2803 1.71966111815559 2.09406531974555 1 1.67614366567144 3001 4559 2803 3441 3978 4504 3676 2941 3678 3871 4120 4130 M12475 GO_LONG_TERM_SYNAPTIC_DEPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_DEPRESSION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. 7/24 Gene Ontology BP GO:0060292 1.11032838015117e-05 1.91147744495436e-05 3865 3700.18181818182 3678 1.11033392792119e-06 2624 0.886370898598065 -1.06024589932487 -1 3.88240295147066 3863 2866 3915 3582 2624 4600 3678 3412 4117 3556 4489 4131 M12737 GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS.html Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. 14/57 Gene Ontology BP GO:0036473 0.0158178945822141 0.0186686539260854 3800 3665.63636363636 3678 0.00144843478350564 2491 1.19505553800536 -0.851160438178686 -1 1.91789043115826 3800 3323 2491 3417 3678 4577 3142 4014 3762 3611 4507 4132 M14119 GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a virus effects a change in the structure or processes of its host organism. 27/58 Gene Ontology BP GO:0019048 4.55821427641704e-06 8.45874855531747e-06 4520 3477.72727272727 3678 4.14383974607237e-07 2297 1.4776623064758 -0.90598612040776 -1 6.95797685720855 4518 3205 2297 3826 2416 2463 3977 3775 3588 3678 4512 4133 M11928 GO_HISTONE_H3_K9_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K9_MODIFICATION.html The modification of histone H3 at a lysine in position 9 of the histone. 12/20 Gene Ontology BP GO:0061647 0.0839184282471183 0.0891201423493528 3660 3587.18181818182 3679 0.00793650793650794 2568 0.661773727538841 -0.648171408985272 -1 0.645026868451813 3659 2761 3054 3966 3944 2568 3679 4329 3996 4384 3119 4134 M12781 GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 254/577 Gene Ontology BP GO:0009896 2.34159345860632e-05 3.8040652303391e-05 3205 3332.45454545455 3680 2.12874398361579e-06 282 1.11881451539443 -0.969474948639179 -1 4.59013142621382 3205 4321 3456 4603 4551 282 2855 4216 3680 4229 1259 4135 M12471 GO_LAGGING_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAGGING_STRAND_ELONGATION.html The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. 6/11 Gene Ontology BP GO:0006273 0.669023335394917 0.680007737793038 3555 3793.72727272727 3681 0.104677007716096 3128 0.470198936567835 -0.470198936567835 -1 0.0731018657329115 3552 4084 3914 3602 4259 3166 3128 3681 4536 4419 3390 4136 M10906 GO_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_SECRETION.html The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. 15/51 Gene Ontology BP GO:0030073 0.0608594893439951 0.0682867590681897 3600 3716.81818181818 3684 0.00569193668242701 2681 1.36470566047982 -0.6976031183132 -1 1.47666258980143 3599 3666 2681 3748 3827 4558 3614 3723 3497 3684 4288 4137 M14289 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleoside across a membrane. 7/13 Gene Ontology BP GO:1901642 0.000503095770938046 0.000684204353973446 4235 3591.27272727273 3685 5.03209704651745e-05 2585 1.6572298748341 -1.60088860161528 -1 4.86855512458746 4232 3221 4219 4013 3271 3685 4149 2585 3616 2742 3771 4138 M10139 GO_RESPONSE_TO_UV_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_C.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. 9/13 Gene Ontology BP GO:0010225 0.275742742869669 0.285011922338351 3500 3842.72727272727 3686 0.0317460317460317 3210 0.759486289062597 0.754475936452915 1 0.384321329304443 3496 3588 3541 4484 4546 3686 3443 3210 4242 4305 3729 4139 M13231 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. 12/36 Gene Ontology BP GO:2000142 0.0839184282471183 0.0891201423493528 2815 3601.54545454545 3687 0.00793650793650794 2000 0.604227060652858 -0.380353983170169 -1 0.588936460931645 2813 3900 3276 3374 4133 3687 2000 4386 4072 4455 3521 4140 M11299 GO_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT.html The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. 86/210 Gene Ontology BP GO:0017038 1.68030569116901e-06 3.49380175732097e-06 3690 3150.09090909091 3688 1.52755179504217e-07 953 1.20076746344843 -0.947427522181195 -1 6.08216580891791 3688 4217 3314 4233 2157 953 3771 3710 3477 4085 1046 4141 M12018 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. 205/532 Gene Ontology BP GO:0000226 2.91252220757007e-08 1.34823934294594e-07 3970 3372.18181818182 3689 2.64774749648018e-09 889 1.53360287892804 -1.17827563598156 -1 9.78033013716195 3966 4430 2767 3369 889 2692 4214 3689 2948 3957 4173 4142 M11611 GO_REGULATION_OF_INTERLEUKIN_10_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-10 secretion. 7/20 Gene Ontology BP GO:2001179 0.0765897756730953 0.0843068583333764 4485 3631.72727272727 3690 0.00793650793650794 2376 1.480862799003 -1.480862799003 -1 1.47653457270204 4485 2376 3776 3394 4300 3959 3185 4301 3690 3552 2931 4143 M13481 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE.html The directed movement of a protein to a specific location in a membrane. 163/432 Gene Ontology BP GO:0090150 0.0157954444763487 0.018646897712608 4540 3471.81818181818 3690 0.00144636408801581 1419 1.51984992499438 -1.34598336835194 -1 2.43985272674357 4536 4477 3441 3769 3690 1419 4456 3665 2098 4190 2449 4144 M16541 GO_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION.html The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. 124/248 Gene Ontology BP GO:0006260 0.557443745451391 0.569212955823798 1865 3600.81818181818 3690 0.0714285714285714 1863 0.830157006230249 -0.768890990817239 -1 0.188585216257882 1863 4251 3466 3859 4205 2882 3353 3690 4366 4263 3411 4145 M11327 GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. 84/198 Gene Ontology BP GO:0098780 1.21313584531703e-08 7.66338738749247e-08 4640 3059.81818181818 3691 1.10285077455143e-09 559 1.80959983032023 -1.29377452294533 -1 11.9525877253744 4638 4094 1309 3691 559 1909 4242 3770 1689 3133 4624 4146 M11109 GO_IMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving IMP, inosine monophosphate. 7/14 Gene Ontology BP GO:0046040 0.0424365455925437 0.0482332634482694 3850 3752.63636363636 3692 0.00432694062105454 2505 0.965278996696693 -1.26822912868535 -1 1.17975920115682 3849 3594 3692 4527 3785 3567 4341 2505 4312 3546 3561 4147 M11899 GO_ADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. 24/64 Gene Ontology BP GO:0046031 0.0839184282471183 0.0891201423493528 3665 3656.54545454545 3692 0.00793650793650794 2659 1.60344196204962 -1.01737145391047 -1 1.5628655180326 3665 4126 2659 3651 4356 4131 3019 3692 3126 3828 3969 4148 M13888 GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION.html The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential. 84/198 Gene Ontology BP GO:0098779 1.21313584531703e-08 7.66338738749247e-08 4640 3063.90909090909 3692 1.10285077455143e-09 560 1.80959983032023 -1.29377452294533 -1 11.9525877253744 4639 4095 1310 3692 560 1910 4243 3805 1690 3134 4625 4149 M16751 GO_HISTONE_H3_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_DEACETYLATION.html The modification of histone H3 by the removal of one or more acetyl groups. 15/23 Gene Ontology BP GO:0070932 0.000284011184008647 0.000396352247475848 4625 3481.63636363636 3692 2.58225323038487e-05 965 0.80200200245351 -0.773072756169339 -1 2.53261099063093 4621 965 2897 2689 3191 4208 3943 4616 3553 3692 3923 4150 M13578 GO_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_GENOME_REPLICATION.html Any process involved directly in viral genome replication, including viral nucleotide metabolism. 15/31 Gene Ontology BP GO:0019079 0.0186680260957114 0.0218381570074044 4110 3628.72727272727 3693 0.00171166734098069 2228 1.09858277955113 -0.951304158763111 -1 1.69361633350567 4109 4104 3107 3738 3693 3197 4493 2228 4235 3689 3323 4151 M15648 GO_MACROMITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMITOPHAGY.html Degradation of a mitochondrion by macroautophagy. 84/198 Gene Ontology BP GO:0000423 1.21313584531703e-08 7.66338738749247e-08 4640 3055 3693 1.10285077455143e-09 561 1.80959983032023 -1.29377452294533 -1 11.9525877253744 4640 4096 1311 3693 561 1911 4244 3697 1691 3135 4626 4152 M16258 GO_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progress through the mitotic cell cycle. 310/683 Gene Ontology BP GO:0007346 0.00801512474703918 0.00967608533554417 3175 3551.09090909091 3693 0.000731315961154447 1211 1.19659767942998 -0.949455818465291 -1 2.23738889691056 3174 4533 3411 4237 4542 1211 3312 4172 3693 4260 2517 4153 M15873 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. 39/96 Gene Ontology BP GO:2001022 1.72703540130089e-06 3.57814608132086e-06 3830 3618.81818181818 3697 1.57003341550269e-07 2167 1.11879791119752 1.27898422753038 1 5.65621197923204 3829 3512 2999 3971 2167 3755 4210 3349 3695 3697 4623 4154 M11133 GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 8/125 Gene Ontology BP GO:0048385 0.0765897756730953 0.0843068583333764 4055 3811.90909090909 3698 0.00793650793650794 2905 1.48187060274341 -1.48187060274341 -1 1.4775394309993 4052 3675 3698 3654 4626 3709 4538 2905 4041 3638 3395 4155 M11959 GO_HEXOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 27/78 Gene Ontology BP GO:0019320 0.0839184282471183 0.0891201423493528 4035 3735.27272727273 3701 0.00793650793650794 2669 1.58353341490624 -1.0676718734344 -1 1.54346077084509 4035 4413 2669 4050 4373 3335 3509 3545 3538 3920 3701 4156 M14613 GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. 4/13 Gene Ontology BP GO:0048484 2.95192761379016e-05 4.72288074115359e-05 4195 3081.90909090909 3704 2.95196682696814e-06 1094 1.26214799915921 -0.972396520363794 -1 5.06809962741104 4191 1190 4257 1733 2823 4476 3911 3704 1094 2089 4433 4157 M15564 GO_RRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. 8/20 Gene Ontology BP GO:0016075 0.000478177570877096 0.000652418002228139 3550 3736.81818181818 3705 4.78280496254161e-05 2857 0.579852364825619 -0.579852364825619 -1 1.71459122488822 3548 3411 4424 3873 3263 2857 3705 3758 4309 4579 3378 4158 M14095 GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. 6/21 Gene Ontology BP GO:1900273 0.203878899249947 0.212816935525518 3270 3663.63636363636 3706 0.0225424320473241 2743 0.547642332710209 0.547642332710209 1 0.341610468070169 3268 3706 4184 3974 4102 3255 2743 2786 4281 4501 3500 4159 M10168 GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of mitosis. 24/63 Gene Ontology BP GO:0045840 0.0217197909557745 0.0252681005782162 4295 3715 3707 0.00199429399050534 1917 2.04048391410344 -1.81760252881268 -1 3.02568295484995 4294 4378 1917 3435 3707 3585 4357 3962 3531 3490 4209 4160 M13019 GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION.html The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. 9/25 Gene Ontology BP GO:0021702 0.0765897756730953 0.0843068583333764 4355 3677.45454545455 3707 0.00793650793650794 1653 1.42236697853069 -1.25933949291975 -1 1.41820971420057 4352 3489 3994 3707 4433 4248 4402 3553 3421 1653 3200 4161 M16659 GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 24/47 Gene Ontology BP GO:0072528 0.0839184282471183 0.0891201423493528 3265 3706.81818181818 3707 0.00793650793650794 3026 0.877172551293014 -0.997095009830152 -1 0.854974871655437 3265 3867 3041 4574 3964 3026 3707 3548 4071 4115 3597 4162 M15459 GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. 6/18 Gene Ontology BP GO:0014741 0.00859999133143006 0.0103632908777134 4410 3308.90909090909 3708 0.00086334556776336 1193 0.920494757702828 0.920494757702828 1 1.69567266308228 1830 3708 4410 4106 4134 2170 1193 3146 4409 4572 2720 4163 M10089 GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS.html A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. 13/26 Gene Ontology BP GO:0006278 0.246990318577286 0.25620555164306 3355 3716.09090909091 3709 0.025459144006256 2782 0.564087932140356 -0.564087932140356 -1 0.309674470476309 3353 4175 3313 3495 3996 2782 3865 3709 4327 4303 3559 4164 M11365 GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 26/67 Gene Ontology BP GO:0032480 0.025610562609285 0.0296385449139856 3710 3660.09090909091 3709 0.00235578642413855 2065 0.99577648374857 -1.01653653046495 -1 1.41252120510777 3709 4338 3303 4555 4603 2258 4332 3427 4052 3619 2065 4165 M13890 GO_OOCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. 13/45 Gene Ontology BP GO:0001556 0.042616649005562 0.0484232487197626 4395 3410.81818181818 3710 0.00395139008538505 2112 2.6607988714629 -2.83861490172976 -1 3.2477987208574 4394 4346 2112 3821 4090 3468 3714 2266 2637 2961 3710 4166 M12141 GO_REGULATION_OF_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of bone development. 9/31 Gene Ontology BP GO:1903010 0.0304961581350164 0.0350652952503421 3340 3608.81818181818 3712 0.00309229314010633 2342 1.88134430295309 1.87804557462821 1 2.54118887932817 3338 3377 3856 3712 3748 4427 3888 3536 3622 2342 3851 4167 M13407 GO_REGULATION_OF_FEVER_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEVER_GENERATION.html Any process that modulates the rate or extent of fever generation. 3/13 Gene Ontology BP GO:0031620 0.0765897756730953 0.0843068583333764 4630 3658.27272727273 3713 0.00793650793650794 2748 1.59486697271216 -1.59486697271216 -1 1.59020555374779 4629 3169 4069 2748 3866 4397 3653 3713 2894 2855 4248 4168 M15485 GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. 76/170 Gene Ontology BP GO:0051053 0.0181656105501832 0.0212825964634117 4455 3805.09090909091 3713 0.00166521480975761 2936 1.3761144280831 -0.855284642088517 -1 2.13576531709244 4453 4488 3099 4512 3689 2936 4300 3213 3343 4110 3713 4169 M16760 GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 121/280 Gene Ontology BP GO:0009895 2.08193447904812e-08 1.05867127625077e-07 4015 3287.54545454545 3713 1.89266772613652e-09 768 1.32688674841917 -1.09770635937781 -1 8.59136308793783 4012 4155 2745 4578 768 1718 4030 4302 3391 3713 2751 4170 M13698 GO_AMINO_SUGAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 7/17 Gene Ontology BP GO:0046348 0.0765897756730953 0.0843068583333764 3715 3159.54545454545 3714 0.00793650793650794 116 1.78254967530673 -0.953007973519374 -1 1.77733972818309 3714 1929 4118 1947 3969 4642 4133 2730 116 3563 3894 4171 M15825 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION.html The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. 15/30 Gene Ontology BP GO:0040001 0.0839184282471183 0.0891201423493528 3330 3617 3715 0.00793650793650794 2539 1.87764406020291 2.20966895384343 1 1.83012873692199 3329 3752 2539 2927 4195 4633 3927 3319 3715 3183 4268 4172 M12199 GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. 7/26 Gene Ontology BP GO:0002829 0.0765897756730953 0.0843068583333764 3060 3561.63636363636 3719 0.00793650793650794 2663 1.0561870577882 1.0561870577882 1 1.05310000395223 3058 3328 3867 3719 4302 3248 2663 3789 3890 3554 3760 4173 M15431 GO_STRIATUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATUM_DEVELOPMENT.html The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. 10/37 Gene Ontology BP GO:0021756 0.00398352533192695 0.00494400110027716 3835 3593.36363636364 3719 0.000362796055674763 2705 1.12902921572344 1.12902921572344 1 2.41667802710296 3835 3063 2705 3408 3529 3759 4365 3719 4159 3213 3772 4174 M13708 GO_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. 301/698 Gene Ontology BP GO:0070925 1.11294474127595e-08 7.24740874297928e-08 4495 3080.27272727273 3721 1.01176795173287e-09 530 1.55315132056354 -1.21199096366365 -1 10.2936642653112 4493 4000 2682 3970 530 869 4501 3936 2448 3721 2733 4175 M14115 GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 16/23 Gene Ontology BP GO:0014733 0.161385165508919 0.168954075187804 3345 3496.45454545455 3722 0.0158730158730159 2197 1.86246095872969 -2.33436934501449 -1 1.33506887196618 3345 3722 2197 3973 3948 3794 2638 3608 4123 2699 4414 4176 M16744 GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION.html A cellular localization which involves only one organism. 533/1309 Gene Ontology BP GO:1902580 4.90319171718623e-07 1.19629632910644e-06 3725 3338 3722 4.90319279904455e-08 1044 1.49214084702015 -1.10704745206768 -1 8.20274437168582 3722 4399 4615 3765 1855 1044 3766 3295 2464 4072 3721 4177 M16379 GO_SUBPALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBPALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. 10/44 Gene Ontology BP GO:0021544 0.00398352533192695 0.00494400110027716 3840 3595.09090909091 3724 0.000362796055674763 2706 1.12902921572344 1.12902921572344 1 2.41667802710296 3836 3064 2706 3409 3530 3760 4366 3724 4160 3218 3773 4178 M10920 GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. 11/30 Gene Ontology BP GO:0044065 0.00485305806575864 0.00597368732749665 3410 3649.09090909091 3726 0.000442163343444712 2954 0.964066741793299 1.15045956965138 1 1.99004834486493 3409 3013 2954 3726 3556 4207 3880 3959 3868 3311 4257 4179 M12355 GO_ATRIAL_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_DEVELOPMENT.html The progression of the atrial septum over time, from its initial formation to the mature structure. 9/26 Gene Ontology BP GO:0003283 0.0765897756730953 0.0843068583333764 2095 3278.45454545455 3726 0.00793650793650794 2094 1.18296196308442 1.18296196308442 1 1.1795043923895 2094 4055 3895 3972 4154 2466 2121 3111 3726 3746 2723 4180 M15415 GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. 6/13 Gene Ontology BP GO:1904293 0.0242020865569627 0.0280715183322453 3315 3583.63636363636 3726 0.00244697824648433 1957 0.849527854053564 -0.849527854053564 -1 1.22366910711724 3315 3833 4401 4387 3726 1957 3417 3013 4549 4571 2251 4181 M11320 GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM.html Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 9/82 Gene Ontology BP GO:0031640 0.0106865817211311 0.0127913892578529 3790 3296.45454545455 3730 0.00107383236270613 1836 1.64231803615526 1.64231803615526 1 2.88599693404277 2131 4516 3730 3787 4068 3306 2190 3168 3790 3739 1836 4182 M12157 GO_STARTLE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STARTLE_RESPONSE.html An action or movement due to the application of a sudden unexpected stimulus. 6/45 Gene Ontology BP GO:0001964 8.40362057530566e-09 6.20318129270973e-08 4000 2951.27272727273 3730 8.40362060708502e-10 451 3.59687787655333 -2.22053514483406 -1 24.0642640584523 3998 4061 3859 735 451 4375 3980 2549 2195 2531 3730 4183 M13106 GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION.html Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. 12/20 Gene Ontology BP GO:0000394 0.407591064930751 0.418497415849951 3735 3785.09090909091 3731 0.0464812523164965 3047 0.617522178531077 -0.721986796362604 -1 0.216853243908342 3731 4347 3255 4130 4101 3284 3326 3047 4417 4449 3549 4184 M15741 GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. 85/214 Gene Ontology BP GO:0060759 2.5011961543587e-05 4.04495079926418e-05 3910 3653.09090909091 3731 2.27384053735824e-06 2775 1.37840044059503 -1.24064287308338 -1 5.62100937638679 3909 4070 2927 3915 2775 3329 3731 4416 3547 3375 4190 4185 M11831 GO_MRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. 5/13 Gene Ontology BP GO:0016556 0.000333468269433763 0.000462867914792515 3085 3354.54545454545 3732 3.33518320493722e-05 1150 0.999492613825375 -0.999492613825375 -1 3.09374856463258 3085 4112 3814 3732 3986 2046 3510 1150 4517 4379 2569 4186 M13939 GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. 6/18 Gene Ontology BP GO:0032645 0.145180867645345 0.152609184622444 3320 3710.09090909091 3732 0.0155641444352364 2047 0.66494201173207 0.701425530546816 1 0.503925130862741 3320 3732 4160 3600 4476 3394 2047 3327 4385 4497 3873 4187 M15436 GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. 9/22 Gene Ontology BP GO:0044320 3.07347078494421e-05 4.90550871588036e-05 3845 3395.72727272727 3732 3.07351329377365e-06 2107 1.38549527274256 -0.957390129245147 -1 5.54220404837564 3843 2107 4404 2297 2835 4339 3914 3732 2670 3089 4123 4188 M15308 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of magnesium ion across a membrane. 5/18 Gene Ontology BP GO:1903830 0.0644901977072051 0.0722035177126967 1920 3535.09090909091 3733 0.00664419459828307 1778 0.836679566006545 0.836679566006545 1 0.886506486704195 1920 3733 4383 4190 4250 2863 1778 3474 4374 4566 3355 4189 M11352 GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. 9/12 Gene Ontology BP GO:0051103 0.114579171236885 0.120907066375649 3735 3477.45454545455 3734 0.0120954778725381 2577 0.741559493332346 -0.741559493332346 -1 0.631602650262866 3008 3943 3734 3735 4169 2695 3021 3409 4221 3740 2577 4190 M16510 GO_ERYTHROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. 16/33 Gene Ontology BP GO:0048821 0.0839184282471183 0.0891201423493528 2985 3660.36363636364 3734 0.00793650793650794 2628 1.45650763467054 1.45650763467054 1 1.41964946839199 2984 3776 2636 4489 4479 4415 3659 2628 3640 3734 3824 4191 M10297 GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. 10/17 Gene Ontology BP GO:1904872 0.114557279653049 0.120907066375649 2370 3457.27272727273 3736 0.0109997382857266 2077 0.850934129786478 -0.850934129786478 -1 0.724759481476229 2366 4135 3060 3736 4418 2077 2325 4210 4459 4312 2932 4192 M14404 GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. 10/17 Gene Ontology BP GO:1904874 0.114557279653049 0.120907066375649 2370 3477.72727272727 3737 0.0109997382857266 2078 0.850934129786478 -0.850934129786478 -1 0.724759481476229 2367 4136 3061 3737 4419 2078 2326 4218 4460 4520 2933 4193 M10644 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process. 120/244 Gene Ontology BP GO:1903364 0.00719116757439669 0.00871537223908218 3230 3470.27272727273 3740 0.000655889233380893 1182 1.04786339548026 -0.9005710752776 -1 2.00346011583305 3230 4034 3417 4374 4507 1182 3407 3740 3817 4183 2282 4194 M14287 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. 245/631 Gene Ontology BP GO:1901361 0.0313233936658091 0.0359897344197852 4150 3584.72727272727 3744 0.00288895186835686 1624 1.51226489071479 -1.08653768768166 -1 2.02679782724938 4146 4536 3429 3997 3744 1624 3950 3529 2819 4224 3434 4195 M14831 GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of chromosome organization. 82/184 Gene Ontology BP GO:2001252 0.0175881741455829 0.0206477604444858 3745 3550.90909090909 3745 0.00161185265368875 1455 1.26281481984674 -1.01076967152737 -1 1.9753379919416 3745 4485 3139 4000 4222 1455 3273 4340 3558 4102 2741 4196 M14369 GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. 9/19 Gene Ontology BP GO:0036499 0.000228861963707347 0.000322686333888009 2785 3524.45454545455 3746 2.28885537133585e-05 2038 0.748588787843166 0.748588787843166 1 2.4259931451736 2783 4209 4231 3746 3171 4002 2038 2637 4525 4515 2912 4197 M14417 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. 30/115 Gene Ontology BP GO:0002707 0.0839184282471183 0.0891201423493528 3750 3490.63636363636 3747 0.00793650793650794 2331 1.88045546193866 -1.53661711750043 -1 1.83286899413572 3747 3818 2331 3895 4202 2966 4355 3982 2939 2709 3453 4198 M16491 GO_PROTEIN_TARGETING_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_LYSOSOME.html The process of directing proteins towards the lysosome using signals contained within the protein. 16/25 Gene Ontology BP GO:0006622 0.112816368821817 0.119182343672286 3670 3543.27272727273 3747 0.0108231215074847 2390 0.965497579663755 -0.965497579663755 -1 0.827928014738522 3668 3822 3180 3747 4633 2390 4036 2619 4339 4009 2533 4199 M12024 GO_SOMATIC_CELL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_CELL_DNA_RECOMBINATION.html Recombination occurring within or between DNA molecules in somatic cells. 16/36 Gene Ontology BP GO:0016444 0.0839184282471183 0.0891201423493528 4200 3779.63636363636 3750 0.00793650793650794 2945 1.29964575718168 -0.855352604318068 -1 1.26675709236332 4200 3750 2945 3528 4318 3411 4389 4135 3174 3726 4000 4200 M14068 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS.html The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 16/36 Gene Ontology BP GO:0002562 0.0839184282471183 0.0891201423493528 4205 3781.63636363636 3751 0.00793650793650794 2946 1.29964575718168 -0.855352604318068 -1 1.26675709236332 4201 3751 2946 3529 4319 3412 4390 4144 3175 3730 4001 4201 M11487 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. 59/102 Gene Ontology BP GO:0000070 0.568590787756011 0.580085042309637 2645 3833.54545454545 3752 0.0735795597825987 2641 0.601863901758316 -0.618624326715589 -1 0.132133584032387 2641 4624 3354 4306 4464 2832 3716 3752 4627 4369 3484 4202 M11474 GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 5/18 Gene Ontology BP GO:0051571 0.0716860639242235 0.0800092295192716 2835 3415.27272727273 3753 0.00741093362046331 2006 0.92435994266353 -0.92435994266353 -1 0.941155380160016 2833 4028 3753 3891 4511 2006 2707 2455 4410 4368 2606 4203 M14086 GO_DETECTION_OF_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_BIOTIC_STIMULUS.html The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. 24/76 Gene Ontology BP GO:0009595 0.0245298088608553 0.0284303301400277 3725 3669.63636363636 3753 0.00225524192161722 2427 1.4649450073263 -1.0470463267709 -1 2.10262185450796 3753 3981 2427 4210 3721 3207 4387 3978 3927 3051 3724 4204 M11168 GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. 17/51 Gene Ontology BP GO:0034122 0.0029280900035687 0.00368032536182174 3775 3296.45454545455 3754 0.000266544947465775 1565 1.69919738470531 -0.794441717936119 -1 3.83931571138855 3754 3773 2500 2883 3528 4291 3773 1565 2340 4025 3829 4205 M11479 GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. 8/22 Gene Ontology BP GO:0051131 0.0765897756730953 0.0843068583333764 3545 3671.09090909091 3755 0.00793650793650794 2530 1.35066541984371 -1.35066541984371 -1 1.34671771304584 3542 3779 3755 3728 4053 2971 4092 4362 3930 3640 2530 4206 M14642 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 34/84 Gene Ontology BP GO:0010803 0.0839184282471183 0.0891201423493528 3755 3686.54545454545 3755 0.00793650793650794 2871 1.4071944627383 -1.3714739137125 -1 1.37158420137537 3755 3770 2871 3361 3994 4000 3595 3587 3867 3386 4366 4207 M11499 GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that activates or increases the frequency, rate or extent of membrane depolarization. 8/17 Gene Ontology BP GO:1904181 0.0475019273224014 0.053779919180178 3805 3573.72727272727 3759 0.0048548962503332 2323 1.57251292222954 -1.4317769069241 -1 1.85291253422588 3126 3731 3759 3805 3801 4010 2323 4251 3554 2910 4041 4208 M15043 GO_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. 346/813 Gene Ontology BP GO:0016071 0.0344774946085162 0.0395159238379019 2830 3576.45454545455 3761 0.00318454289901964 1657 0.940193989568636 -0.741982024966799 -1 1.22465776144984 2826 4534 3515 4169 4515 1657 3271 3761 3978 4547 2568 4209 M16690 GO_PROSTANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. 9/30 Gene Ontology BP GO:0046457 0.147859119791321 0.155108425935631 2960 3659.36363636364 3762 0.0158730158730159 2309 2.48628549932511 2.48628549932511 1 1.86794593587947 2960 4145 4606 3373 4146 3450 2309 3807 4168 3762 3527 4210 M16882 GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. 9/22 Gene Ontology BP GO:0000737 0.00591475255018859 0.0072230920806222 2200 3093.63636363636 3763 0.00059305547114153 1093 1.20871230768181 -1.20871230768181 -1 2.40250815878377 2197 4057 4631 4344 4139 1444 1093 2324 3932 3763 2106 4211 M11541 GO_MAGNESIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSPORT.html The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 3/15 Gene Ontology BP GO:0015693 0.226118037661457 0.235079724330977 2620 3620.90909090909 3766 0.0253078408520715 2619 0.836679566006545 0.836679566006545 1 0.488348858496996 2619 3882 3766 4096 4629 3140 2716 2827 4311 4373 3471 4212 M14777 GO_POSITIVE_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SIZE.html Any process that increases cell size. 12/21 Gene Ontology BP GO:0045793 0.0839184282471183 0.0891201423493528 2975 3634.09090909091 3766 0.00793650793650794 2533 2.18046988939203 2.18046988939203 1 2.12529134295968 2974 4051 2533 3317 4143 3766 3742 4099 4044 3905 3401 4213 M12536 GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of T cell death by apoptotic process. 23/41 Gene Ontology BP GO:0070232 0.00309667248106333 0.00388380613981011 4570 3532.90909090909 3773 0.000281912718114982 1463 2.43599103571717 -1.95722062026253 -1 5.45124408182744 4569 4127 1463 3739 3495 3773 4605 4183 2138 2462 4308 4214 M13471 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. 17/54 Gene Ontology BP GO:0046641 0.0839184282471183 0.0891201423493528 3370 3627.90909090909 3774 0.00793650793650794 2484 1.44955335065792 -0.927869007381074 -1 1.4128711674862 3369 3774 2484 3976 3873 3038 3899 4637 3853 3359 3645 4215 M12306 GO_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_ACTIVATION.html The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. 8/42 Gene Ontology BP GO:0045576 0.0177245971334678 0.020786891763246 2980 3623.18181818182 3776 0.00178675774067132 1380 0.574826072255345 0.65181956031562 1 0.897606165488974 2976 4276 3888 3753 4422 3153 1380 3393 4427 4411 3776 4216 M11628 GO_MEMBRANE_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. 8/24 Gene Ontology BP GO:0046466 0.000401125240289192 0.000551666022115734 4555 3578.72727272727 3777 4.01197664345188e-05 2230 1.41427975341491 -1.5728432186629 -1 4.27758532884015 4552 2530 3777 2230 3243 3858 4588 4561 2698 2912 4417 4217 M15017 GO_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location. 977/2309 Gene Ontology BP GO:0008104 1.43302481203506e-07 4.33454996891125e-07 3715 3051.90909090909 3777 1.43302490444527e-08 212 1.40214159706929 -1.10993957442142 -1 8.28183835402084 3711 3837 4334 4041 1480 212 3777 3955 2502 4117 1605 4218 M16333 GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. 20/61 Gene Ontology BP GO:0046640 0.0303329010044049 0.0348862173305553 4425 3711.36363636364 3778 0.00279630696648254 2477 1.34171245720429 1.65209504457171 1 1.81506111993757 4421 3318 2477 3533 3741 3803 4529 4385 3778 2644 4196 4219 M12508 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that activates or increases the frequency, rate or extent of response to oxidative stress. 10/22 Gene Ontology BP GO:1902884 0.0839184282471183 0.0891201423493528 4275 3754.27272727273 3780 0.00793650793650794 2624 1.26837455180048 -0.910321144168735 -1 1.23627722709234 3756 4206 2624 4273 4131 3451 4272 4402 3780 3196 3206 4220 M11141 GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. 20/52 Gene Ontology BP GO:0050869 1.91209825104784e-07 5.44989084077049e-07 4500 3522.18181818182 3781 1.73827128839557e-08 1556 1.22633404775756 -0.996662221326884 -1 7.13021748809823 4499 2980 2643 3879 1556 3478 4442 3447 3781 3912 4127 4221 M11801 GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. 22/37 Gene Ontology BP GO:1900087 0.0455230616848765 0.0516150367284204 3670 3634.72727272727 3781 0.00422666034175755 2632 1.0033945158293 1.05996881591555 1 1.19893279183063 2750 4228 2833 4343 3781 3816 2632 3668 4297 3965 3669 4222 M13425 GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM.html Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. 8/41 Gene Ontology BP GO:0030277 0.0292804549970858 0.0337505265472252 3750 3447.63636363636 3781 0.002967357018286 1618 2.47691599538954 -1.52600985665715 -1 3.38380573774151 3749 3781 4074 2369 3745 4575 4116 3848 1618 2137 3912 4223 M14763 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE.html Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. 3/43 Gene Ontology BP GO:0050884 0.00060180359826697 0.000810375320984206 3995 3610.54545454545 3782 6.01966635817802e-05 2540 0.490848666676342 -0.525763901960058 -1 1.40850952009465 3994 2540 4290 3782 3291 2833 3821 2983 4202 4535 3445 4224 M15886 GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. 9/26 Gene Ontology BP GO:0042762 0.0417400577890066 0.04746487590359 3110 3627.72727272727 3782 0.00425454361562552 2176 1.28699254634582 -0.328789034457426 -1 1.58128790397487 3106 3803 4474 3893 3782 4386 2176 2567 4305 3758 3655 4225 M11663 GO_CYTOKINETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINETIC_PROCESS.html A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). 9/20 Gene Ontology BP GO:0032506 0.0910426800147406 0.0965314371565291 2415 3529.18181818182 3785 0.00950029815859542 2017 0.844742172349594 -0.844742172349594 -1 0.796161093713228 2411 4423 3785 4535 4607 2017 2070 4146 4467 3742 2618 4226 M15375 GO_PROTEIN_K63_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. 18/32 Gene Ontology BP GO:0070536 0.675053693362 0.685986933307019 3665 3908.45454545455 3788 0.0971424443551416 2972 0.578077241586382 -0.578077241586382 -1 0.0878335935027974 3663 4420 3267 4063 4372 2972 3788 3647 4534 4569 3698 4227 M11686 GO_REGULATION_OF_PROTEIN_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_GLYCOSYLATION.html Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. 5/16 Gene Ontology BP GO:0060049 0.0466877703640395 0.0529044539904377 3765 3702.27272727273 3790 0.00476986795850397 3077 1.52143248146692 1.52143248146692 1 1.80279040293964 3761 3077 3790 4246 3797 4112 3114 3087 4126 3274 4341 4228 M10874 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. 36/130 Gene Ontology BP GO:0002704 0.0839184282471183 0.0891201423493528 4075 3607.36363636364 3791 0.00793650793650794 2327 1.65477942233387 -1.4774750296585 -1 1.61290384734365 4074 3791 2327 4202 4194 3158 4474 4284 3194 2451 3532 4229 M11204 GO_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_PROLIFERATION.html The expansion of a B cell population by cell division. Follows B cell activation. 13/53 Gene Ontology BP GO:0042100 0.0839184282471183 0.0891201423493528 3800 3291.81818181818 3791 0.00793650793650794 1575 2.11865536407215 2.49734992197818 1 2.06504107820104 3797 3989 2440 2461 4536 3870 4049 2747 1575 2955 3791 4230 M10868 GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 10/20 Gene Ontology BP GO:0090153 0.000279852611102337 0.000390901225435665 4330 3575.18181818182 3792 2.54443832999722e-05 2604 0.968022802284197 -1.15641772561943 -1 3.06228597037632 4330 2831 2604 3063 3189 3455 4240 3950 4012 3792 3861 4231 M11066 GO_RESPONSE_TO_PHENYLPROPANOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PHENYLPROPANOID.html Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. 5/17 Gene Ontology BP GO:0080184 0.0765897756730953 0.0843068583333764 3800 3682.09090909091 3793 0.00793650793650794 2506 4.16275638951858 -4.16275638951858 -1 4.15058996537507 3798 3783 3682 4314 3974 3916 4352 2506 3114 3271 3793 4232 M14871 GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. 22/42 Gene Ontology BP GO:0045839 0.0839184282471183 0.0891201423493528 3920 3657.90909090909 3793 0.00793650793650794 2724 1.89053000366538 2.62477993260421 1 1.84268859241325 3920 3793 2724 3118 4313 3460 3222 4323 2949 4098 4317 4233 M11098 GO_RESPONSE_TO_TYPE_I_INTERFERON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TYPE_I_INTERFERON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 50/123 Gene Ontology BP GO:0034340 5.83936434273001e-05 8.86598058969766e-05 4240 3827.54545454545 3796 5.30865394563495e-06 2859 1.19957267010443 1.29334877735029 1 4.5122630037335 4240 3714 2859 4570 2949 3796 4518 4230 3655 3148 4424 4234 M13873 GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is regionalized in the dorsoventral axis. 5/25 Gene Ontology BP GO:0021904 0.435369722646862 0.446525651038078 3730 3759.27272727273 3796 0.0555555555555556 3054 1.04291378532163 -1.04291378532163 -1 0.338981400420629 3727 3226 4150 3054 4494 3548 3904 3866 4306 3281 3796 4235 M11494 GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. 10/20 Gene Ontology BP GO:1905038 0.000279852611102337 0.000390901225435665 4335 3577.09090909091 3797 2.54443832999722e-05 2605 0.968022802284197 -1.15641772561943 -1 3.06228597037632 4331 2832 2605 3064 3190 3456 4241 3957 4013 3797 3862 4236 M15508 GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. 15/31 Gene Ontology BP GO:0006760 0.00173725414809802 0.00223436870072552 4245 3677.36363636364 3798 0.00015805704622087 2347 1.50018031295586 -1.19695717483825 -1 3.69144957987242 4241 3798 2347 3950 3417 3282 4309 4237 3085 3182 4603 4237 M11783 GO_AEROBIC_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AEROBIC_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. 33/63 Gene Ontology BP GO:0009060 0.0526420077688204 0.059295691914273 3055 3647.63636363636 3802 0.00490413793925263 2532 0.592837040492358 -0.58246390570424 -1 0.675212872988266 3054 3921 3388 4415 3802 2532 3261 3808 4318 4181 3444 4238 M16462 GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT.html The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. 81/166 Gene Ontology BP GO:0030705 0.029857794935669 0.034356813354724 4375 3670.72727272727 3802 0.00275189884450758 2660 1.02376756072505 -0.980191831972853 -1 1.3912580815596 4374 4121 3332 4135 3737 3036 3426 2660 3845 3910 3802 4239 M12540 GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. 10/22 Gene Ontology BP GO:0031061 0.298735036746822 0.308022823809792 3705 3811.09090909091 3803 0.0317460317460317 2978 0.778881889185178 -0.776387701637905 -1 0.369756447288995 3702 4134 2978 4108 4382 3230 3774 3924 4253 3803 3634 4240 M11399 GO_MULTICELLULAR_ORGANISMAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MOVEMENT.html Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. 30/75 Gene Ontology BP GO:0050879 0.0531128590652728 0.0597970428322167 4205 3487.45454545455 3804 0.00494910971293063 1751 1.91103018394022 -1.84372593146506 -1 2.1700854148238 4205 3314 1751 3954 3804 3910 3699 4313 2704 2328 4380 4241 M12266 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. 4/13 Gene Ontology BP GO:0043371 0.0360152492936387 0.0411666180380021 3805 3821.63636363636 3804 0.00366126150411286 2992 0.660651854809574 0.660651854809574 1 0.849638261210159 3804 3383 3879 3410 3770 3952 3735 2992 4382 4408 4323 4242 M14514 GO_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. 11/26 Gene Ontology BP GO:0030219 0.000122811895965668 0.000178527123659549 3930 3719.09090909091 3805 1.11653411183938e-05 2816 1.02429993157394 -0.730668743612887 -1 3.56393780513036 3926 3558 2816 3237 3062 4599 3805 3476 3960 3863 4608 4243 M15233 GO_MUSCULOSKELETAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCULOSKELETAL_MOVEMENT.html The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. 30/75 Gene Ontology BP GO:0050881 0.0531128590652728 0.0597970428322167 4210 3486.81818181818 3805 0.00494910971293063 1752 1.91103018394022 -1.84372593146506 -1 2.1700854148238 4206 3315 1752 3955 3805 3911 3700 4296 2705 2329 4381 4244 M15480 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. 4/17 Gene Ontology BP GO:0046639 0.0360152492936387 0.0411666180380021 3805 3886.09090909091 3805 0.00366126150411286 2990 0.660651854809574 0.660651854809574 1 0.849638261210159 3805 3384 4414 3411 3771 3953 3736 2990 4383 4576 4324 4245 M16197 GO_HISTONE_H3_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_ACETYLATION.html The modification of histone H3 by the addition of an acetyl group. 30/51 Gene Ontology BP GO:0043966 0.0839184282471183 0.0891201423493528 3430 3669.09090909091 3809 0.00793650793650794 2323 0.928650162163683 -0.750253014249856 -1 0.905149804942559 3429 4498 3274 4467 4032 2323 3602 3809 4021 4084 2821 4246 M16605 GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY.html Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex. 6/15 Gene Ontology BP GO:0051488 0.0358600249691459 0.0410194865562317 2510 3380.81818181818 3810 0.00364521925840242 1702 0.648233651182285 -0.648233651182285 -1 0.834603366074386 2507 4083 4590 3810 4308 1702 1993 2553 4566 4631 2446 4247 M13928 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 10/28 Gene Ontology BP GO:0010592 0.000440125809168747 0.000603159425020807 3960 3640.72727272727 3811 4.00194440153316e-05 2712 1.0195021244022 -0.950403130838328 -1 3.04687638275576 3957 2792 2882 2712 3242 4354 3198 4288 4296 3811 4516 4248 M10901 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. 9/29 Gene Ontology BP GO:2000144 0.0504993087948307 0.0570066352381227 3880 3862.45454545455 3812 0.00516849918251054 3130 0.604227060652858 -0.380353983170169 -1 0.697775324459364 3879 3757 3654 3130 3812 4357 3305 3560 4213 4338 4482 4249 M13633 GO_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIVISION.html Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. 152/381 Gene Ontology BP GO:0051302 6.57168882684058e-09 5.47858747037603e-08 4585 3309.54545454545 3812 5.97426258770096e-10 321 1.7511696764129 -1.33391057759525 -1 11.8035765531894 4582 4402 2121 3493 321 2380 4265 4207 2820 4002 3812 4250 M13959 GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 10/23 Gene Ontology BP GO:1900103 0.00924300913680303 0.0111150715934153 3990 3676.18181818182 3812 0.000843824761667647 2649 0.994024225982994 -1.04641466939113 -1 1.80305976021781 3989 3850 2773 2767 3630 3793 4295 2649 4365 3812 4515 4251 M14924 GO_NEUROBLAST_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_DIVISION.html The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. 6/21 Gene Ontology BP GO:0055057 1.38822885066795e-07 4.23213824927858e-07 4200 3239 3812 1.38822893739103e-08 1469 1.32265195591073 -1.42965528460233 -1 7.82507703298287 4199 1640 4319 2673 1469 3812 4022 4147 2444 2548 4356 4252 M15072 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. 10/39 Gene Ontology BP GO:0046636 0.100691820359215 0.106591911064258 3630 3698.81818181818 3812 0.00960174246942901 2686 0.844790713301431 0.844790713301431 1 0.762443404145873 3626 3530 2686 3812 3878 4242 3542 2871 4207 3817 4476 4253 M14797 GO_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_REACTION.html The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. 6/28 Gene Ontology BP GO:0007340 1.9238775008929e-06 3.91779089326567e-06 4175 3446.18181818182 3813 1.92387916648202e-07 1705 1.11611218906676 -0.950692637670347 -1 5.60183140102689 4175 1705 4293 2469 2233 4423 3873 3813 2901 3449 4574 4254 M11449 GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 4/12 Gene Ontology BP GO:0046349 0.0510962725948888 0.0576524893458248 4635 3810.90909090909 3814 0.00523106327396053 2810 0.983647739014141 -0.941237732057863 -1 1.13147180392807 4635 2810 3747 3570 3814 4068 4099 3796 4188 3111 4082 4255 M14660 GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 10/35 Gene Ontology BP GO:0032660 0.0839184282471183 0.0891201423493528 3920 3481.45454545455 3816 0.00793650793650794 2697 1.34820872780202 -0.828779327635385 -1 1.31409114244622 3918 4054 2697 2759 3925 2810 3360 3145 3907 3816 3905 4256 M11462 GO_DETECTION_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_OTHER_ORGANISM.html The series of events in which a stimulus from another organism is received and converted into a molecular signal. 20/63 Gene Ontology BP GO:0098543 0.0564485948353904 0.063475617781719 3045 3547.63636363636 3818 0.00526829470859576 2550 1.36609283080738 -1.0470463267709 -1 1.51839943721084 3045 3868 2550 4211 3818 2741 3859 4612 3957 3158 3205 4257 M10697 GO_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_DNA_REPLICATION.html The DNA-dependent DNA replication that takes place as part of the cell cycle. 4/13 Gene Ontology BP GO:0044786 0.939610620218653 0.945311399712938 3475 3879.45454545455 3819 0.244740743129704 3363 0.626084966781134 -0.626084966781134 -1 0.014194909131436 3472 4064 3620 3363 4344 3470 3823 3799 4574 4326 3819 4258 M16281 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. 46/94 Gene Ontology BP GO:1901989 0.0839184282471183 0.0891201423493528 2670 3697.45454545455 3819 0.00793650793650794 2445 1.2565776422625 1.41233182685863 1 1.22477884674696 2666 4623 2784 4364 4586 4246 2445 3358 3819 4011 3770 4259 M16319 GO_KINETOCHORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 5/12 Gene Ontology BP GO:0051383 0.67725561156488 0.688073917832765 3480 3948.36363636364 3820 0.106929240794794 3025 0.717412076866619 -0.717412076866619 -1 0.108125758575461 3479 4248 4549 3820 4407 3025 3435 3489 4581 4617 3782 4260 M10234 GO_NUCLEOTIDE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. 28/76 Gene Ontology BP GO:0046939 0.0839184282471183 0.0891201423493528 3575 3785 3822 0.00793650793650794 2755 1.66252704292281 -1.01723842791965 -1 1.62045540887903 3573 4224 2805 4031 4500 2755 4481 4623 3118 3703 3822 4261 M12841 GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. 9/19 Gene Ontology BP GO:0007007 0.0477221741781007 0.054016103049469 2440 3297.45454545455 3823 0.00487790946116933 1791 0.571387382365975 -0.571387382365975 -1 0.672263695127599 2439 4078 3967 3823 4129 1791 2026 3117 4100 4433 2369 4262 M10521 GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 19/37 Gene Ontology BP GO:0006221 0.0839184282471183 0.0891201423493528 3290 3715.09090909091 3824 0.00793650793650794 2911 0.854281570676082 -0.998917528314312 -1 0.832663163596239 3288 4128 2995 4488 3940 2911 3824 3564 4011 4060 3657 4263 M15691 GO_POSITIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_STORAGE.html Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 13/29 Gene Ontology BP GO:0010884 0.0839184282471183 0.0891201423493528 3465 3718.45454545455 3824 0.00793650793650794 1940 1.61164602331363 -1.38844000175055 -1 1.57086196968688 3461 3824 1940 3631 4201 4529 3280 4581 4015 2970 4471 4264 M15862 GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 9/16 Gene Ontology BP GO:0032785 0.000313422574818047 0.000436348130398858 1675 2843.63636363636 3824 3.13466788764492e-05 528 0.988255275015897 -0.988255275015897 -1 3.08247172488462 1674 4056 4469 3824 4516 746 528 1270 4567 4593 1037 4265 M16064 GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. 10/29 Gene Ontology BP GO:0045346 0.751985672431077 0.761812184800062 4180 3801.63636363636 3824 0.119047619047619 2815 0.686305750764614 -0.685414879470825 -1 0.0752708802582536 4180 3408 2815 3071 4181 3533 4611 4149 4435 3824 3611 4266 M15466 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. 104/264 Gene Ontology BP GO:0031110 0.0839184282471183 0.0891201423493528 3280 3640 3825 0.00793650793650794 1964 1.31222897708637 -0.856352895967093 -1 1.2790218849319 3278 4614 3134 4077 4537 1964 3617 4106 3825 4139 2749 4267 M16358 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE.html Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. 13/40 Gene Ontology BP GO:0043576 0.0839184282471183 0.0891201423493528 3080 3658.54545454545 3825 0.00793650793650794 2939 0.918227457394226 1.02720958116659 1 0.894990854135911 3078 3186 2939 4333 4117 3837 3314 3825 4017 3522 4076 4268 M16380 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 10/23 Gene Ontology BP GO:0016447 0.0839184282471183 0.0891201423493528 3665 3644.36363636364 3825 0.00793650793650794 2838 0.822366318637927 -0.822366318637927 -1 0.801555549727381 3662 3848 3105 3882 4262 2891 4246 3469 4060 3825 2838 4269 M16234 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 220/537 Gene Ontology BP GO:0010639 0.0839184282471183 0.0891201423493528 3760 3875.81818181818 3826 0.00793650793650794 3113 1.24904734746865 -0.909444726807316 -1 1.21743911142275 3758 4474 3306 3999 4446 3113 3800 3826 3474 4193 4245 4270 M13895 GO_SPERMATID_NUCLEUS_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_NUCLEUS_DIFFERENTIATION.html The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. 11/134 Gene Ontology BP GO:0007289 0.0126731836141043 0.0150605558024793 4535 3851.54545454545 3827 0.00115879838299616 2875 0.998312295636785 0.765614279838307 1 1.688580541972 4535 3827 2875 3742 3658 3597 4591 3800 4046 3859 3837 4271 M11674 GO_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPAIR.html Any process that modulates the frequency, rate or extent of DNA repair. 48/109 Gene Ontology BP GO:0006282 0.0608892978154498 0.0683036989024241 3430 3650.18181818182 3828 0.00569480576913731 2457 0.925995617341401 -0.745534499373625 -1 1.00186924809382 3430 3862 3205 4058 3828 2457 3438 4406 4042 4109 3317 4272 M12348 GO_ERROR_FREE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_FREE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. 9/26 Gene Ontology BP GO:0070987 0.131828215095076 0.138856261952459 3240 3682.45454545455 3828 0.0140371154208521 2503 0.4490424784433 -0.483182950224738 -1 0.357402256398204 3237 4079 3893 3828 3921 2503 3275 3534 4420 4413 3404 4273 M14015 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. 11/42 Gene Ontology BP GO:0042534 0.0258206903217354 0.0298519584571259 4320 3650.18181818182 3828 0.00237534676157502 2111 1.10532316306121 -1.26579613952213 -1 1.56471749497404 4318 3699 2673 4113 3884 3925 4484 2111 3828 3323 3794 4274 M12966 GO_PHOTORECEPTOR_CELL_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_MAINTENANCE.html Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. 17/52 Gene Ontology BP GO:0045494 0.0064893563727041 0.00789158764758123 3865 3763.81818181818 3831 0.000591688863441212 2986 1.05269741108652 -0.741393146416544 -1 2.054839843167 3865 3429 2994 4546 3597 4232 2986 3965 3831 3776 4181 4275 M15684 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. 8/30 Gene Ontology BP GO:0060850 0.0765897756730953 0.0843068583333764 3990 3715.90909090909 3831 0.00793650793650794 2374 1.65326839877358 1.42223839471952 1 1.64843629371884 3990 2374 4440 2742 4581 4264 3831 3683 3716 2935 4319 4276 M16185 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 6/23 Gene Ontology BP GO:0032700 0.00902329191643755 0.0108705615900414 4615 3774.36363636364 3832 0.000906014158681879 1972 1.34820872780202 -0.828779327635385 -1 2.45760453885382 4614 3832 4525 1972 3635 3477 4161 3946 3272 3457 4627 4277 M10176 GO_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 159/308 Gene Ontology BP GO:0007059 0.579202092395104 0.590521588711126 2705 3857.63636363636 3833 0.0756746367060241 2704 0.833744728583361 -0.771400231483767 -1 0.177047518286472 2704 4613 3467 4375 4417 2849 3802 3833 4515 4291 3568 4278 M12587 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization. 11/39 Gene Ontology BP GO:0031113 0.0839184282471183 0.0891201423493528 4470 3816.45454545455 3833 0.00793650793650794 3151 0.940468139992467 -0.630087761439151 -1 0.916668720430647 4466 4238 3151 3833 4453 3309 3281 3652 4009 3857 3732 4279 M14974 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. 5/20 Gene Ontology BP GO:0032691 0.0602073382892006 0.0675876865756186 2550 3556.54545454545 3834 0.00619036034733672 1753 0.406189353344464 0.430305056356184 1 0.441196937417236 2548 3834 4326 3818 3901 3035 1753 3884 4505 4542 2976 4280 M13490 GO_INOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. 5/13 Gene Ontology BP GO:0006020 0.00076433179995175 0.00101801277888008 4250 3807.54545454545 3835 7.64594818677126e-05 2501 0.692533682487282 -0.648445721632418 -1 1.92356738139212 4247 3103 4085 3705 3331 3408 4641 2501 4552 4475 3835 4281 M13712 GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT.html A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. 59/132 Gene Ontology BP GO:0044774 0.0186657286241207 0.0218381570074044 4210 3726.90909090909 3838 0.00171145487125921 2721 1.43503552303204 -1.2650462180929 -1 2.21230453890438 4209 4408 2721 3552 3692 2962 4142 4450 3094 3928 3838 4282 M14528 GO_MITOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_RECOMBINATION.html The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. 24/43 Gene Ontology BP GO:0006312 0.782832250634147 0.791871490129487 2645 3857.18181818182 3839 0.129620474245231 2642 0.473866387420793 -0.473866387420793 -1 0.0445786222086058 2642 4634 3275 3996 4365 3128 3717 3839 4626 4522 3685 4283 M16076 GO_POSITIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the cell cycle. 202/497 Gene Ontology BP GO:0045787 9.59783276884492e-09 6.67334137483928e-08 3840 3406.36363636364 3840 8.72530255519721e-10 467 1.42954657289408 -1.29867010402278 -1 9.5220200589089 4064 4538 2657 3851 467 2494 3838 4465 3216 4040 3840 4284 M10426 GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 41/93 Gene Ontology BP GO:0036498 0.017956460356237 0.0210534963217192 4170 3530 3841 0.00164588349007998 1466 0.781668484986697 -0.7838770139821 -1 1.21658024674803 3783 3841 3405 4414 4167 1466 3264 3940 4089 4168 2293 4285 M12249 GO_EPITHELIAL_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_CELL_ADHESION.html The attachment of an epithelial cell to another epithelial cell via adhesion molecules. 9/22 Gene Ontology BP GO:0090136 0.000180732378336318 0.000258117635378507 2680 3585.27272727273 3841 1.8074707890569e-05 2296 0.77518151178035 -0.722262885425152 -1 2.58194517576427 2677 4077 3877 3603 3137 3555 2296 4002 3968 4405 3841 4286 M14604 GO_FUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. 5/15 Gene Ontology BP GO:0006004 0.0615751523560611 0.0690230401712196 3215 3827.90909090909 3841 0.00633509843529741 3213 0.740401489009284 0.740401489009284 1 0.797940938906292 3213 3786 4255 4026 3841 3667 3933 3216 4415 4525 3230 4287 M14166 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. 10/21 Gene Ontology BP GO:0032717 0.101731924274665 0.107668412219573 4370 3725.63636363636 3843 0.00970592953128825 2527 0.882141652724181 -1.01624829428454 -1 0.792579974638836 4370 3902 2898 4040 4193 3415 3843 2527 4180 3813 3801 4288 M16625 GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that modulates the frequency, rate or extent of viral release from host cell. 17/50 Gene Ontology BP GO:1902186 0.404278594128646 0.415188124870449 4085 3764 3845 0.0459977865562619 2637 0.872681628363281 -0.882169631693334 -1 0.309249858995664 4085 3845 2797 4118 4499 2637 4369 3712 4343 3782 3217 4289 M13829 GO_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENETIC_IMPRINTING.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 9/23 Gene Ontology BP GO:0071514 0.0675481621218262 0.0755543523805442 3850 3568 3846 0.00696937817002125 2448 1.65136544689796 -1.20610785032769 -1 1.7195099334302 3892 3704 4140 4099 3850 2525 3846 4191 3472 3081 2448 4290 M15764 GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. 162/617 Gene Ontology BP GO:0002768 0.0293724043097759 0.0338402166774912 4305 3399.18181818182 3849 0.00270654983863625 1612 1.51060395325901 -1.01036475699087 -1 2.06207516775883 4305 4186 3083 3849 3891 1612 3993 3223 2726 3999 2524 4291 M11864 GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE.html The movement of organelles or other particles from one location in the cell to another along microtubules. 67/133 Gene Ontology BP GO:0010970 0.0436438076410356 0.0495447919015473 4125 3454.27272727273 3851 0.0040485867554341 1899 1.03092759769357 -0.984865085413461 -1 1.24884463216733 4122 3915 3311 4272 3908 1899 4234 2276 3800 3851 2409 4292 M15581 GO_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 8/25 Gene Ontology BP GO:0000305 0.0689417662357176 0.0770388978658091 4020 3840.27272727273 3851 0.00711789234778315 3226 0.845176327750378 -0.845176327750378 -1 0.873423051487291 4019 3995 4428 3313 3851 3300 3670 4640 4141 3660 3226 4293 M11279 GO_MONOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 34/87 Gene Ontology BP GO:0046365 0.0839184282471183 0.0891201423493528 3865 3584.63636363636 3853 0.00793650793650794 1984 1.43078633829907 -1.09648202925956 -1 1.39457906773297 3864 4261 2711 4046 4352 1984 3936 3853 3540 3714 3170 4294 M11859 GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 16/35 Gene Ontology BP GO:0090200 0.0443911421483349 0.0503562357670948 3855 3505.72727272727 3854 0.0041193642425198 1661 2.90167615571405 -0.717988052112597 -1 3.49602822675138 3854 4130 2586 3832 3780 3890 4344 2304 1661 4004 4178 4295 M15079 GO_PROTEIN_K63_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. 23/59 Gene Ontology BP GO:0070534 0.0765525440513208 0.0843068583333764 3930 3802 3854 0.00721397866972703 3185 0.965312125797912 -1.12351219983038 -1 0.962490666278724 3927 3926 3185 4055 3854 3249 4578 3578 4335 3769 3366 4296 M12451 GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. 6/12 Gene Ontology BP GO:0009396 0.101855937286507 0.10777509499117 3855 3784.18181818182 3855 0.010684985362366 3102 0.52302519556291 -0.52302519556291 -1 0.469714829913674 3855 3102 3909 3347 3892 3167 3460 4312 4408 4418 3756 4297 M12981 GO_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. 108/204 Gene Ontology BP GO:0000819 0.660402298994951 0.671392133618033 2515 3818.36363636364 3856 0.0935153986360139 2514 0.783601226835645 -0.793732730217269 -1 0.125854651119847 2514 4549 3391 4081 4421 2946 3856 3818 4559 4276 3591 4298 M16264 GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that activates or increases the frequency, rate or extent of receptor recycling. 8/17 Gene Ontology BP GO:0001921 0.0738996030088957 0.0824203355201303 3685 3928.72727272727 3857 0.00764786810218723 2964 0.644735808344599 -0.731183831608206 -1 0.648733471316162 3682 2964 4537 4100 3857 3371 3530 4641 4284 4611 3639 4299 M12389 GO_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE.html Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. 468/1049 Gene Ontology BP GO:0000278 0.0839184282471183 0.0891201423493528 3185 3746.18181818182 3858 0.00793650793650794 2531 1.21877359638471 -0.916288212384112 -1 1.18793145915808 3184 4599 3487 4006 4083 2531 3848 3858 3876 4296 3440 4300 M15478 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY.html The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 87/229 Gene Ontology BP GO:0000184 0.0839184282471183 0.0891201423493528 4280 3806.45454545455 3858 0.00793650793650794 2538 1.06818016361067 -0.533803773482689 -1 1.041148900389 4168 4489 3516 3560 4109 2538 3858 4278 3696 4279 3380 4301 M15293 GO_NUCLEUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. 79/272 Gene Ontology BP GO:0006997 0.0839184282471183 0.0891201423493528 3710 3789.54545454545 3859 0.00793650793650794 2576 1.16321846846546 -0.979203175490442 -1 1.13378219329356 3708 4550 3186 4511 4403 2576 3987 3224 3859 4119 3562 4302 M13843 GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. 6/11 Gene Ontology BP GO:0002676 0.075960423976099 0.0843068583333764 4300 3189.27272727273 3860 0.00786891442072224 1437 2.91596964975348 -2.96311648239729 -1 2.90744712899537 4298 2573 4143 1853 3860 4172 4074 2663 1437 1731 4278 4303 M11074 GO_CELLULAR_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. 27/63 Gene Ontology BP GO:0006879 8.72614984186459e-05 0.000129194877920208 3775 3865.18181818182 3864 7.93317816169386e-06 2866 1.34955140036033 -1.06878938584238 -1 4.87157175412688 3773 3864 2866 4498 3013 4137 4427 4531 3521 3303 4584 4304 M11658 GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. 11/35 Gene Ontology BP GO:0046471 0.0181135283057969 0.0212322928361058 3870 3277.18181818182 3868 0.00166040060565524 970 2.34523927915089 -1.03236908520047 -1 3.64210971348373 3868 4133 2256 3871 3949 4162 3456 1997 970 3316 4071 4305 M15372 GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle phase transition. 209/442 Gene Ontology BP GO:1901987 0.0158927538948367 0.018747473662024 4025 3687.63636363636 3868 0.00145533977579494 1985 1.15552098121574 -1.00528090116621 -1 1.85248057897685 4022 4322 3407 3941 3680 1985 3868 4233 3701 4170 3235 4306 M10437 GO_MULTI_ORGANISM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_TRANSPORT.html The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. 38/115 Gene Ontology BP GO:0044766 0.0839184282471183 0.0891201423493528 3120 3721.90909090909 3870 0.00793650793650794 2752 1.20565885281289 -1.26064688500309 -1 1.17514859350708 3637 4370 3116 3933 4321 3118 4311 2752 4066 3870 3447 4307 M12215 GO_MEMBRANE_TUBULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_TUBULATION.html A modification in a plasma membrane resulting in formation of a tubular invagination. 8/14 Gene Ontology BP GO:0097320 0.000627669534598274 0.000843005394602195 3755 3770.81818181818 3870 6.27846891175933e-05 2587 0.848655575377315 -1.13251504956554 -1 2.42174495969425 3751 2990 3870 4181 3299 4334 2587 4343 4215 3644 4265 4308 M13896 GO_MULTI_ORGANISM_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_LOCALIZATION.html A localization which involves another organism. 38/115 Gene Ontology BP GO:1902579 0.0839184282471183 0.0891201423493528 3120 3727.18181818182 3873 0.00793650793650794 2798 1.20565885281289 -1.26064688500309 -1 1.17514859350708 3638 4371 3117 3934 4322 3119 4312 2798 4067 3873 3448 4309 M12129 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition. 11/30 Gene Ontology BP GO:1902751 0.0496696263780111 0.0561382851200354 4145 3763.27272727273 3874 0.00462070908164226 2852 0.944308437497106 0.880549631834605 1 1.09635264545803 4142 3874 2908 3477 3792 4313 3891 2852 4404 3317 4426 4310 M14253 GO_REGULATION_OF_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ISOTYPE_SWITCHING.html Any process that modulates the frequency, rate or extent of isotype switching. 10/29 Gene Ontology BP GO:0045191 0.0839184282471183 0.0891201423493528 4635 3838.18181818182 3874 0.00793650793650794 2863 1.14025079420111 -0.828779327635385 -1 1.11139573237429 4631 3280 2863 4102 4224 3706 3989 3927 3874 3814 3810 4311 M16412 GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. 7/15 Gene Ontology BP GO:0048711 0.0173431244585241 0.0203806952318217 4080 3942.72727272727 3874 0.00174799829054214 3072 1.16356076110323 1.31134322920884 1 1.82618815283499 4079 3072 4561 3874 3696 4249 3643 4256 3811 3580 4549 4312 M11748 GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. 10/22 Gene Ontology BP GO:0006206 0.0839184282471183 0.0891201423493528 4380 3514.36363636364 3875 0.00793650793650794 2232 1.62140178096695 -0.817743168341432 -1 1.58037085094888 4379 2962 2405 2232 3875 4033 4055 4242 2409 3799 4267 4313 M15284 GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS.html Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. 8/15 Gene Ontology BP GO:0051457 0.0160288555919463 0.0188984196326579 2145 3116.90909090909 3875 0.00161456589865854 1456 0.650872126494299 -0.650872126494299 -1 1.04134537787244 2141 3875 4380 3968 3898 1456 1553 2344 4062 4564 2045 4314 M14484 GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 120/307 Gene Ontology BP GO:0051494 0.00195181079143082 0.00249648967069237 3880 3716.63636363636 3876 0.000177594960535307 2666 1.39647052087491 -1.06075037655813 -1 3.37380542515541 3876 4482 2666 3916 3435 3608 3424 3989 3308 3981 4198 4315 M14886 GO_MACROMOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. 509/1194 Gene Ontology BP GO:0009057 4.27411185920735e-05 6.62815676763518e-05 3500 3365.36363636364 3876 4.27419406757752e-06 357 1.37438387481365 -0.98662075828668 -1 5.33100055712429 3498 4527 4310 4162 4244 357 3226 3876 2865 4271 1683 4316 M13860 GO_REGULATION_OF_MRNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_POLYADENYLATION.html Any process that modulates the frequency, rate or extent of mRNA polyadenylation. 8/13 Gene Ontology BP GO:1900363 0.00287005800238392 0.00361129520462562 1855 2992.54545454545 3877 0.000287377150903782 922 0.92435994266353 -0.92435994266353 -1 2.09563579233959 1852 3877 4146 4039 4220 1123 922 1842 4474 4494 1929 4317 M15403 GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. 8/17 Gene Ontology BP GO:0033235 0.275742742869669 0.285011922338351 4395 3979.72727272727 3879 0.0317460317460317 3504 1.08860111796607 1.08860111796607 1 0.550862736909462 3504 4394 4398 4209 4393 3879 3656 3708 4255 3658 3723 4318 M12290 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY.html Any process that modulates the activity of the enzyme lipoprotein lipase. 5/17 Gene Ontology BP GO:0051004 0.0765897756730953 0.0843068583333764 4395 3542.36363636364 3885 0.00793650793650794 2145 1.99078478544544 -2.37273008564036 -1 1.98496624296336 4391 3256 3885 3267 4080 3991 3919 3769 2145 2276 3987 4319 M13508 GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. 131/273 Gene Ontology BP GO:0045930 1.00589564686798e-06 2.22716904549738e-06 4345 3477.90909090909 3885 9.14451006172003e-08 2024 1.41595649548494 -1.1377768799386 -1 7.42916764165093 4345 4154 2973 3250 2024 2451 3885 4051 3189 4022 3913 4320 M15661 GO_MATURATION_OF_5_8S_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA.html Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. 15/29 Gene Ontology BP GO:0000460 0.380500188221954 0.39111409650532 3100 3814.09090909091 3885 0.0425972896386101 2603 0.483560490027723 -0.483560490027723 -1 0.183002272816505 3099 4300 3234 4458 4111 2603 3693 3885 4550 4584 3438 4321 M16521 GO_MONOAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOAMINE_TRANSPORT.html The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/24 Gene Ontology BP GO:0015844 0.000112188310535207 0.000164059945138571 4390 3875.54545454545 3892 1.12193974735326e-05 3063 1.44623908529539 -0.678657906030477 -1 5.08129967996877 4388 3075 4574 3457 3063 3845 4536 4544 3962 3295 3892 4322 M12352 GO_CENTRIOLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE_ASSEMBLY.html A cellular process that results in the assembly of one or more centrioles. 9/27 Gene Ontology BP GO:0098534 0.284324315731912 0.293489950632118 3275 3727.09090909091 3894 0.0328994590986145 2512 0.817855228956749 -0.817855228956749 -1 0.404193125608181 3271 4390 3894 4553 4330 2512 2721 3909 4494 3745 3179 4323 M10706 GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization of an epithelial cell. 15/37 Gene Ontology BP GO:0090162 6.63336686756506e-07 1.55313778951612e-06 4410 3625.54545454545 3897 6.03033533421512e-08 1908 1.00493932936066 -1.10419450990048 -1 5.41869424388981 4406 4421 2862 3897 1908 3009 4546 2844 3806 3993 4189 4324 M15250 GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME.html The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. 8/23 Gene Ontology BP GO:0045292 0.0953241348234556 0.10100181606237 2265 3403.36363636364 3898 0.00996784436964267 2010 0.715902882948594 -0.715902882948594 -1 0.66166612079946 2262 4059 4375 3898 4241 2039 2010 2701 4488 4561 2803 4325 M15316 GO_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_LOCALIZATION.html A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. 32/79 Gene Ontology BP GO:0031503 0.0839184282471183 0.0891201423493528 3180 3572.90909090909 3898 0.00793650793650794 2390 1.42896411205287 -0.992655377935071 -1 1.39280295421895 3176 3952 2684 4524 3911 4252 2390 4016 3200 3299 3898 4326 M11451 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. 6/12 Gene Ontology BP GO:0070202 0.033299462667799 0.0382223498557703 2865 3515.09090909091 3899 0.00338092313159598 1681 0.902795291110037 -0.902795291110037 -1 1.18805724496686 2862 4150 3748 4112 3899 1681 1883 4595 4548 4366 2822 4327 M16132 GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. 3/22 Gene Ontology BP GO:0002523 0.176746056121435 0.184993674159563 3665 3850.45454545455 3899 0.0192611440215771 2126 0.41786887179364 -0.274617942138078 -1 0.284262693947101 3664 4184 4515 3899 4189 3785 2126 2979 4584 4604 3826 4328 M14069 GO_CELLULAR_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 3/13 Gene Ontology BP GO:0071294 0.386086746459241 0.396680850588682 4225 3888.36363636364 3901 0.0476190476190476 3088 0.593913242201241 -0.593913242201241 -1 0.221381262562047 4225 3736 4179 3173 4230 3618 3840 3088 4282 4500 3901 4329 M15817 GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. 14/49 Gene Ontology BP GO:1901186 0.0839184282471183 0.0891201423493528 4045 3705.27272727273 3901 0.00793650793650794 2375 1.6593369472074 -1.87946802604613 -1 1.61734604080632 4042 4301 2375 3901 4427 4533 2598 3763 3866 3046 3906 4330 M11867 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT.html The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. 13/52 Gene Ontology BP GO:0072488 0.0839184282471183 0.0891201423493528 3770 3636.45454545455 3902 0.00793650793650794 2414 1.01954178112607 0.972617417385893 1 0.993741346792737 3766 2861 2414 3225 3958 4539 3955 3928 3946 3507 3902 4331 M14634 GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. 4/19 Gene Ontology BP GO:0021527 0.000275236653908797 0.000385032776167082 4420 3439.09090909091 3902 2.75270749699452e-05 2090 2.04049539257963 -3.00589649012904 -1 6.46743625008713 4419 2250 4264 2669 3201 4471 3902 4252 2150 2090 4162 4332 M14979 GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS.html The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. 5/26 Gene Ontology BP GO:0006607 0.562604368603265 0.574103754598893 3900 3865.18181818182 3905 0.0793650793650794 2283 1.27553285387293 -1.5063336552028 -1 0.285361149835765 3899 3622 4328 3040 4517 4390 3620 3905 4375 2283 4538 4333 M12278 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C.html The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. 5/17 Gene Ontology BP GO:0006122 0.606828352985884 0.618144809766007 3300 3840.27272727273 3906 0.0891261815587805 2924 0.421834005345458 -0.421834005345458 -1 0.0818028441329915 3300 4282 3880 3906 4280 2924 3323 3934 4539 4409 3466 4334 M14164 GO_REGULATION_OF_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTON_TRANSPORT.html Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/21 Gene Ontology BP GO:0010155 0.000199900212971596 0.000284007554720661 3910 3780.81818181818 3906 1.9991819729133e-05 2528 1.00729494786111 -1.04452613650349 -1 3.31624467659307 3906 2528 4195 2880 3156 4495 4284 3961 3869 3752 4563 4335 M15465 GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 12/29 Gene Ontology BP GO:0032075 0.111394759726596 0.117707298454844 3930 3651.09090909091 3906 0.0106791316737595 2559 0.861492854797607 1.0803542860524 1 0.743067588669692 3930 4011 2988 2809 4175 3436 3796 2559 4325 3906 4227 4336 M15253 GO_VIRAL_LATENCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LATENCY.html The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. 5/16 Gene Ontology BP GO:0019042 0.332771038365283 0.342632787315143 3790 4005.09090909091 3907 0.0396545371475906 3375 0.484341082948553 -0.484341082948553 -1 0.209137896013428 3790 3971 4376 3900 4052 3375 3907 3881 4364 4562 3878 4337 M11083 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. 14/46 Gene Ontology BP GO:0002719 0.0839184282471183 0.0891201423493528 3800 3605.45454545455 3908 0.00793650793650794 2616 1.11406201043544 -1.18208960098484 -1 1.08586967442232 3796 3936 2616 4349 3913 2777 3908 3964 3998 3036 3367 4338 M10904 GO_NEGATIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPAIR.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. 6/17 Gene Ontology BP GO:0045738 0.307315862781467 0.316659465356048 3730 3761.45454545455 3909 0.0360521828410127 2546 0.57289517244245 -0.57289517244245 -1 0.265582255051779 3730 4352 3656 3909 4065 2546 3193 4011 4472 4339 3103 4339 M13478 GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY.html Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. 7/26 Gene Ontology BP GO:0001539 0.115243109444244 0.12158004025213 3830 3879.90909090909 3909 0.0121695815041269 3299 0.687345822303159 -0.769238398119287 -1 0.583889604274423 3827 3378 4084 3584 3909 3299 4308 4222 4169 4474 3425 4340 M16116 GO_PEPTIDYL_METHIONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_METHIONINE_MODIFICATION.html The modification of peptidyl-methionine. 7/12 Gene Ontology BP GO:0018206 0.113718582778713 0.120080823252573 2640 3565.63636363636 3909 0.0119995000527495 2114 0.598482039778564 -0.598482039778564 -1 0.511394805713333 2636 3909 4513 4197 3922 2114 3036 3339 4151 4603 2802 4341 M12849 GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. 2/14 Gene Ontology BP GO:0072283 0.822186329212759 0.830232954879261 3855 4039.2 3910 0.174603174603175 3694 0.27285108157725 -0.459375948207312 -1 0.0204645419143403 3852 3836 3968 NA 4363 3841 3694 4137 4478 4435 3788 4342 M13754 GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION.html The directed movement of the nucleus to a specific location within a cell. 8/29 Gene Ontology BP GO:0040023 3.32485439944557e-06 6.36327245532803e-06 3725 3267.27272727273 3910 3.3248593740516e-07 89 5.81869432397637 5.81869432397637 1 28.0666466154069 3724 4274 4129 3053 4138 4528 3910 428 89 3654 4013 4343 M14299 GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. 7/22 Gene Ontology BP GO:0006577 0.0765897756730953 0.0843068583333764 3870 3905.36363636364 3910 0.00793650793650794 3080 0.984740061604904 -1.01668768916401 -1 0.981861821307737 3867 4107 4221 4386 3910 3080 4523 4028 3848 3567 3422 4344 M15714 GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 127/307 Gene Ontology BP GO:0043244 0.0804372231322294 0.0884580831366511 3910 3572.72727272727 3910 0.00759437629037785 1948 1.35431345261555 -1.05632366598563 -1 1.3241124829002 3910 4481 2765 4365 4136 1948 4235 3613 3424 3990 2433 4345 M13659 GO_TRNA_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_TRANSPORT.html The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 18/40 Gene Ontology BP GO:0051031 0.0839184282471183 0.0891201423493528 3805 3788.90909090909 3913 0.00793650793650794 2735 1.45118586597148 -1.85140898805718 -1 1.41446237083776 3803 4343 2912 3920 4366 3459 4573 2735 3913 4044 3610 4346 M13243 GO_TOXIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. 3/16 Gene Ontology BP GO:0009404 0.0269643902747536 0.0311432000113634 3250 3928.09090909091 3914 0.00272972745979277 3246 0.397952660709683 0.397952660709683 1 0.556556112446381 3246 3914 4036 4024 3735 3656 3557 4227 4592 4456 3766 4347 M13366 GO_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_GROWTH.html The increase in size or mass of an entire multicellular organism, as opposed to cell growth. 48/121 Gene Ontology BP GO:0035264 0.0839184282471183 0.0891201423493528 3725 3961.18181818182 3915 0.00793650793650794 3157 1.28638758942375 -1.50809228849322 -1 1.25383443197734 4367 4439 3157 4469 3915 3859 4072 4061 3725 3787 3722 4348 M15868 GO_DNA_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. 13/17 Gene Ontology BP GO:0006266 0.220868531991483 0.22967359328924 3660 3742.18181818182 3916 0.0224332277076617 3046 0.626200029552523 -0.655820023204415 -1 0.37137045875743 3658 4050 3046 4124 3976 3063 3621 3916 4543 3945 3222 4349 M13932 GO_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. 207/504 Gene Ontology BP GO:0051052 0.0839184282471183 0.0891201423493528 4080 3747.36363636364 3918 0.00793650793650794 2069 1.31722388650719 -0.972572381915249 -1 1.28389039461458 4077 4539 3297 3858 3918 2069 4063 4231 3786 4180 3203 4350 M12624 GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE.html A cascade of processes induced by the detection of DNA damage within a cell. 60/128 Gene Ontology BP GO:0042770 0.0839184282471183 0.0891201423493528 3920 3672.09090909091 3919 0.00793650793650794 2345 1.48999236710459 -1.28025864370813 -1 1.45228684583821 3919 4553 2972 4234 4514 2345 3463 4033 3130 4088 3142 4351 M12504 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY.html The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. 8/14 Gene Ontology BP GO:0000244 0.0438820367816687 0.0497908838654174 3110 3504.81818181818 3920 0.00447734477802074 2308 0.233908358299001 -0.240497226501614 -1 0.282884428470532 3107 4058 3920 3981 4144 2454 2766 2308 4449 4420 2946 4352 M14472 GO_NUCLEAR_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_IMPORT.html The directed movement of substances into the nucleus. 72/180 Gene Ontology BP GO:0051170 0.0509687445673639 0.0575225768172753 4180 3710.45454545455 3920 0.00474448608907539 2511 1.24416965826598 -1.06476153330596 -1 1.43227690714594 4177 4361 3295 4158 3796 2600 4541 3441 3920 4015 2511 4353 M10447 GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. 32/77 Gene Ontology BP GO:2000573 0.0839184282471183 0.0891201423493528 4210 3734.27272727273 3921 0.00793650793650794 2432 1.65401065057308 1.79079662876446 1 1.61215452989946 4210 4223 2432 3921 4473 2928 4213 3717 3519 3297 4144 4354 M10217 GO_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_RECOMBINATION.html Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. 32/91 Gene Ontology BP GO:0000018 0.1497329666903 0.157003198812796 3395 3755.09090909091 3926 0.0146377046604866 2549 0.775612374542233 -0.599237584251973 -1 0.578920847873088 3392 4372 3212 4229 3926 2549 4024 3841 4345 4175 3241 4355 M10491 GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. 151/367 Gene Ontology BP GO:0032886 0.0839184282471183 0.0891201423493528 4165 3885.72727272727 3926 0.00793650793650794 3017 1.41462935126703 -0.866341386611372 -1 1.37883094475792 4163 4609 3065 3770 3894 3017 4449 3926 3608 4078 4164 4356 M16283 GO_MYELOID_DENDRITIC_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_ACTIVATION.html The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 14/33 Gene Ontology BP GO:0001773 0.00134521989143853 0.00174855989808206 4590 3695.27272727273 3927 0.000122367559023089 2188 0.836019210141041 -0.949145762366922 -1 2.13979637619953 4586 3401 2952 4256 3388 3927 4118 2188 4048 3979 3805 4357 M14323 GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. 20/54 Gene Ontology BP GO:0031663 0.048753941852598 0.055130188022799 4285 3785.90909090909 3928 0.00453355714428671 2232 1.30279959203203 -1.11310497182257 -1 1.52208202643794 4551 3928 2232 3248 3790 3774 4282 4376 4014 3165 4285 4358 M11828 GO_PROTEIN_LOCALIZATION_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_LYSOSOME.html A process in which a protein is transported to, or maintained in, a location within a lysosome. 18/30 Gene Ontology BP GO:0061462 0.212385615394845 0.221298566489736 4305 3755.72727272727 3929 0.0214704003660225 2764 0.965497579663755 -0.965497579663755 -1 0.587050779828004 4302 3929 3222 4212 4587 3011 3871 2764 4341 4042 3032 4359 M12121 GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 15/43 Gene Ontology BP GO:0010743 0.0839184282471183 0.0891201423493528 4155 3727.54545454545 3929 0.00793650793650794 1973 1.93409495617176 -2.25850478180566 -1 1.88515110278802 4155 3797 1973 4101 3929 4520 3830 4163 3354 3176 4005 4360 M13037 GO_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_CYCLE.html The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. 27/66 Gene Ontology BP GO:0007098 0.0839184282471183 0.0891201423493528 3930 3868.27272727273 3929 0.00793650793650794 2932 1.20656905524368 -0.941090326069591 -1 1.17603576261751 3929 4225 2932 3839 4354 3145 3896 4081 3975 3921 4254 4361 M16327 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. 15/37 Gene Ontology BP GO:0000083 0.984032135556253 0.985943289898076 3795 4036.18181818182 3929 0.313471132516056 2910 0.736097392128064 -0.725956903944529 -1 0.00420070079544198 3795 4202 2910 3754 4501 3650 4568 3925 4546 4618 3929 4362 M14673 GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 37/68 Gene Ontology BP GO:1901028 0.000461971561548066 0.000631234243751521 4230 3746.63636363636 3930 4.20062361938619e-05 2978 1.30565783627484 -0.746833831356358 -1 3.87813225473057 4230 4410 3007 3930 3247 2978 4544 3045 3403 4071 4348 4363 M15996 GO_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_DUPLICATION.html The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 17/48 Gene Ontology BP GO:0051298 0.0839184282471183 0.0891201423493528 4275 3851.27272727273 3934 0.00793650793650794 2712 1.37158740295642 -1.005648292321 -1 1.33687820358548 4275 4102 2712 3182 3987 3934 4548 3715 3843 3780 4286 4364 M16224 GO_TRANSCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCYTOSIS.html The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. 6/12 Gene Ontology BP GO:0045056 0.0765897756730953 0.0843068583333764 4440 3874.90909090909 3934 0.00793650793650794 3074 1.57997594425984 -2.27131923794754 -1 1.57535804634623 4439 3074 4530 3521 3934 3635 3866 4169 3973 3458 4025 4365 M11206 GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. 102/249 Gene Ontology BP GO:0051054 0.0560531405291353 0.0630614808521384 3965 3640 3936 0.00523040150726443 1820 1.28514123025203 1.49710224930687 1 1.43181374299449 3963 4089 3074 3936 4243 1820 3832 4306 3803 4021 2953 4366 M13570 GO_TRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. 13/23 Gene Ontology BP GO:0030488 0.41434042400569 0.425333316086319 3650 3775.18181818182 3939 0.0474739959406658 2838 0.694542598218007 -0.694542598218007 -1 0.239363660196387 3647 4105 3028 4278 4085 2838 3939 3525 4533 4479 3070 4367 M14424 GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. 11/29 Gene Ontology BP GO:0031442 0.0459912222867207 0.0521331164739366 4345 3907.81818181818 3940 0.00427107170227217 3235 0.531628279846785 0.531628279846785 1 0.63308970169882 4344 3940 3235 4121 3783 3347 3854 3954 4419 4521 3468 4368 M11012 GO_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PHASE_TRANSITION.html The cell cycle process by which a cell commits to entering the next cell cycle phase. 152/387 Gene Ontology BP GO:0044770 0.0839184282471183 0.0891201423493528 4545 4103.09090909091 3942 0.00793650793650794 3402 1.3103567068792 -0.787038291773047 -1 1.27719699385496 3607 4542 3402 3942 4624 3857 3905 4556 3900 4256 4543 4369 M11077 GO_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 93/281 Gene Ontology BP GO:0006413 0.0941781280030253 0.0998103283081594 3535 3648.45454545455 3944 0.008951747068673 2000 0.657534866236144 -0.586288411080955 -1 0.610865670083522 3533 4487 3497 3944 4089 2000 2905 4298 4367 4274 2739 4370 M13681 GO_ACROSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_ASSEMBLY.html The formation of the acrosome from the spermatid Golgi. 8/18 Gene Ontology BP GO:0001675 0.0765897756730953 0.0843068583333764 4130 3989.27272727273 3944 0.00793650793650794 3616 0.891156720509499 -1.11647336267651 -1 0.88855199022215 4126 3616 4115 3797 3930 4392 4379 3944 3771 3653 4159 4371 M16277 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. 22/34 Gene Ontology BP GO:0000291 0.499676804480374 0.511915137511557 4455 3866.63636363636 3944 0.0610139313128567 2731 0.620758609460121 -0.620758609460121 -1 0.167567116499531 2970 4502 3338 4577 4455 2731 3944 3720 4451 4612 3233 4372 M14534 GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. 43/110 Gene Ontology BP GO:0031023 0.0839184282471183 0.0891201423493528 3650 3810.36363636364 3945 0.00793650793650794 2992 1.16833038698392 -1.03101160795311 -1 1.13876475107538 3649 4332 3153 3614 4264 2992 3673 4199 4036 4057 3945 4373 M12680 GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING.html Any process that activates or increases the frequency, rate or extent of telomere capping. 5/20 Gene Ontology BP GO:1904355 0.0334361141954097 0.0383697177976488 3155 3383.27272727273 3947 0.00339501210517401 1577 0.404995102375355 -0.659493962915331 -1 0.532335581389881 3152 4315 3947 4339 4471 1776 1577 2480 4403 4428 2328 4374 M12696 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 6/15 Gene Ontology BP GO:0032968 0.000420064889466442 0.000576688729093048 4635 4030.36363636364 3952 4.20144315127859e-05 3248 0.684151629604833 0.564047473075484 1 2.05702827633483 4633 3380 3952 3346 3248 3885 4590 4468 4508 4429 3895 4375 M12762 GO_MYELOID_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_ACTIVATION.html A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. 60/180 Gene Ontology BP GO:0002274 6.74338003018639e-05 0.000101390911529001 4035 3868.18181818182 3953 6.13053339573016e-06 2931 1.21656556502477 -1.27818967122251 -1 4.51037663185584 4034 4072 2931 4560 2967 3945 3577 4604 3840 3953 4067 4376 M14922 GO_MULTI_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_METABOLIC_PROCESS.html A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. 92/247 Gene Ontology BP GO:0044033 0.0839184282471183 0.0891201423493528 4060 3752.09090909091 3953 0.00793650793650794 2571 0.958579566601217 -0.950528604622863 -1 0.934321824497805 4057 4486 3514 3444 4231 2571 3953 3660 4050 4273 3034 4377 M16532 GO_CELLULAR_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_DEFENSE_RESPONSE.html A defense response that is mediated by cells. 29/121 Gene Ontology BP GO:0006968 0.013170780483731 0.0156318849146122 4585 3884.63636363636 3953 0.00120457250051083 2564 1.45768314244543 -0.997292970788151 -1 2.44369642912206 4585 3953 2564 4500 3662 3489 4171 4567 3707 3469 4064 4378 M10674 GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 28/65 Gene Ontology BP GO:0009247 0.000112875751633284 0.000165013260337953 3955 3719.54545454545 3955 1.02619584894128e-05 2851 0.931172491778491 -0.750651814765588 -1 3.26945998132884 3955 2851 3109 4009 3047 3798 4020 4173 3409 4144 4400 4379 M12341 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 13/19 Gene Ontology BP GO:0033160 0.0692480532050002 0.0773625387465871 4120 3883.27272727273 3956 0.00650262714447146 2639 1.72067215658873 -0.739338359774914 -1 1.77527112736656 4116 4269 2639 3682 3845 4031 4495 3140 3956 3938 4605 4380 M11741 GO_HISTONE_H2A_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_MONOUBIQUITINATION.html The modification of histone H2A by addition of a single ubiquitin group. 13/15 Gene Ontology BP GO:0035518 0.0387503927767868 0.0441842027658696 4365 3997.45454545455 3961 0.00358638683998194 3138 0.597695846060434 -0.411521427841144 -1 0.75162802455297 4365 4233 3138 3917 3766 3319 4473 3867 4558 4375 3961 4381 M10352 GO_CELLULAR_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 12/40 Gene Ontology BP GO:0098586 0.0839184282471183 0.0891201423493528 4015 3739 3963 0.00793650793650794 2529 1.14236843199695 1.36645801168862 1 1.11345978183842 4014 3847 2781 4204 3963 4193 2529 2976 4090 3891 4641 4382 M13222 GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. 6/14 Gene Ontology BP GO:0050812 0.0991569140074113 0.105014952494619 4355 4011.54545454545 3963 0.0103880864201947 3139 0.328789034457426 -0.328789034457426 -1 0.298715280961451 4354 3621 4035 3963 3887 3139 4285 3931 4529 4453 3930 4383 M12616 GO_MICROTUBULE_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_DEPOLYMERIZATION.html The removal of tubulin heterodimers from one or both ends of a microtubule. 7/16 Gene Ontology BP GO:0007019 0.0765897756730953 0.0843068583333764 3405 4045 3964 0.00793650793650794 3403 1.55163135403748 -0.961194012720058 -1 1.54709629703401 3403 4519 3938 3964 4582 4481 3928 3861 4093 3558 4168 4384 M15517 GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA.html Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. 13/32 Gene Ontology BP GO:0060330 0.0176316482316134 0.0206935648987313 4525 3862.45454545455 3965 0.00161586919599744 2868 1.19635167272057 -0.961351507242609 -1 1.87030533607644 4522 3988 2868 4129 3687 3653 4452 3972 3965 3520 3731 4385 M13655 GO_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_SALVAGE.html Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. 8/17 Gene Ontology BP GO:0043174 8.515867621733e-06 1.49656220165429e-05 4025 3591.72727272727 3967 8.51590025590961e-07 1760 0.787447295489648 -0.875704597020179 -1 3.52678837102172 4021 1760 4111 3697 2582 3199 4122 4285 3967 4484 3281 4386 M12862 GO_PROTEIN_O_LINKED_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_MANNOSYLATION.html The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. 8/16 Gene Ontology BP GO:0035269 0.0765897756730953 0.0843068583333764 3970 3837.54545454545 3970 0.00793650793650794 2489 0.858111047816013 -0.866828471031667 -1 0.855602897990069 4372 2489 3970 3269 3956 4297 3967 4522 2827 4437 4107 4387 M13272 GO_PROTEIN_AUTOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOUBIQUITINATION.html The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. 27/55 Gene Ontology BP GO:0051865 0.0837036270585649 0.0891201423493528 3970 3723.54545454545 3970 0.00791536316322557 2471 0.899943659979748 -0.984566764045891 -1 0.877169741228952 3970 4377 3209 4505 4535 2845 4268 2471 4315 3676 2788 4388 M13834 GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. 3/19 Gene Ontology BP GO:0060707 0.286888145194252 0.296070606387399 3035 3783.45454545455 3972 0.0332464720148379 2387 0.716623747885129 0.716623747885129 1 0.351634203460924 3035 3972 4141 3583 4247 3632 2387 4176 4464 4490 3491 4389 M16958 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 31/73 Gene Ontology BP GO:0090502 0.059524344251109 0.0668532971354376 4515 3651.90909090909 3972 0.00556351283340659 2003 0.624236432310462 -0.646472206632644 -1 0.680785956429302 3151 4629 3331 4514 4495 2003 3972 2609 4512 4641 2314 4390 M15236 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI.html The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. 46/82 Gene Ontology BP GO:0042147 0.102100675292994 0.108009440734876 4045 3801.54545454545 3973 0.00974289360335143 2565 0.903828187829265 -1.02360082715992 -1 0.81091246250397 4044 3790 3283 4107 3881 2565 4553 3973 4234 4092 3295 4391 M11966 GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 9/24 Gene Ontology BP GO:0045723 0.000392036605753345 0.000539806038111738 4635 3629.90909090909 3974 3.92105784645492e-05 1131 2.3243917230779 -1.57364866809798 -1 7.05064588394718 4634 3434 3835 4015 3238 3974 4462 4150 1131 3074 3982 4392 M12879 GO_REGULATION_OF_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXCRETION.html Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. 8/33 Gene Ontology BP GO:0044062 0.0011342636228229 0.00148348901430048 4140 3594.90909090909 3974 0.000113484298834797 2112 3.82922814775975 -3.83257846248176 -1 10.0547128378293 4138 3067 3974 2404 3379 4573 4278 4398 2112 2919 4302 4393 M14885 GO_LATERAL_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. 14/49 Gene Ontology BP GO:0021670 0.00290287879639886 0.00365061382764895 4110 3277 3974 0.000264246927969491 623 2.50697249243799 3.40751808100709 1 5.67266599185726 4110 3483 2157 3164 4036 4267 4136 1564 623 3974 4533 4394 M13607 GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. 12/22 Gene Ontology BP GO:0034315 7.90797696858462e-08 2.71774515656095e-07 4535 3305.90909090909 3976 7.18907022985419e-09 228 0.580612891083718 -0.582048884555681 -1 3.53869280798334 4533 228 3040 2741 1266 4057 3976 4399 3985 3898 4242 4395 M15875 GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE.html Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 7/17 Gene Ontology BP GO:0010984 0.0765897756730953 0.0843068583333764 3900 3893.54545454545 3976 0.00793650793650794 2756 1.24075848208579 1.6501384785175 1 1.23713199322345 3896 3019 4471 3788 4208 4322 4535 4241 3617 2756 3976 4396 M15645 GO_PROTEIN_K48_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. 28/61 Gene Ontology BP GO:0070936 0.557443745451391 0.569212955823798 4560 4006.90909090909 3978 0.0714285714285714 3198 0.852470349302679 -0.915911261647755 -1 0.193654102199175 4557 3978 3198 4457 4256 3772 3945 3616 4358 3932 4007 4397 M12790 GO_PROSTAGLANDIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. 13/44 Gene Ontology BP GO:0006693 0.0839184282471183 0.0891201423493528 3980 3772.63636363636 3979 0.00793650793650794 2583 1.42705679516027 -0.897442443077854 -1 1.3909439033379 3979 4013 2583 3545 4509 4336 3165 3206 4033 3513 4617 4398 M15959 GO_PROSTANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. 13/44 Gene Ontology BP GO:0006692 0.0839184282471183 0.0891201423493528 3980 3771.18181818182 3980 0.00793650793650794 2584 1.42705679516027 -0.897442443077854 -1 1.3909439033379 3980 4014 2584 3546 4510 4337 3166 3173 4034 3521 4618 4399 M14587 GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 8/26 Gene Ontology BP GO:0032924 0.00195556366995282 0.00250060096931725 4035 3675.18181818182 3983 0.000195728670752882 1876 1.07364932085837 1.20207617909558 1 2.59317271924285 4032 1876 4254 2881 3448 3914 3983 4528 4143 2930 4438 4400 M15474 GO_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of DNA replication. 86/211 Gene Ontology BP GO:0006275 0.0839184282471183 0.0891201423493528 4070 3674.90909090909 3983 0.00793650793650794 2296 1.57423550017163 2.00353491406349 1 1.53439814646085 4154 4360 2741 3998 4070 2296 4068 3792 3623 3983 3339 4401 M10686 GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE.html Any process in which a protein is transported to, or maintained at, the kinetochore. 7/13 Gene Ontology BP GO:0034501 0.981477999924634 0.983596450172691 3510 3908.72727272727 3984 0.328928510540028 2766 0.691041069495191 -0.691041069495191 -1 0.00460746994751704 3506 3912 3617 2766 4447 3672 3984 4119 4596 4325 4052 4402 M14361 GO_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. 10/18 Gene Ontology BP GO:0030851 0.0839184282471183 0.0891201423493528 3985 3925 3984 0.00793650793650794 2617 1.47652893383765 -0.449273527812808 -1 1.43916411433302 3984 3901 2617 3663 4218 4009 4310 4180 3939 3815 4539 4403 M11336 GO_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION.html The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 23/52 Gene Ontology BP GO:0006306 0.0839184282471183 0.0891201423493528 4500 3900.81818181818 3985 0.00793650793650794 3071 1.17700324311008 -0.748709504309276 -1 1.14721813440414 4496 4449 3166 4455 4162 3071 4128 3666 3428 3985 3903 4404 M12020 GO_HISTONE_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MONOUBIQUITINATION.html The modification of histones by addition of a single ubiquitin group. 19/26 Gene Ontology BP GO:0010390 0.0362641044964031 0.0414306685966534 4230 3929.63636363636 3986 0.00335236724755571 2964 0.662844978657796 -0.667940685252337 -1 0.850750239169782 4226 4342 3103 3986 3759 2964 4525 3540 4586 4392 3803 4405 M10731 GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA processing. 21/61 Gene Ontology BP GO:0050685 0.287943656322029 0.297093865845151 3855 3794.54545454545 3987 0.0304008758114296 2477 0.531628279846785 0.531628279846785 1 0.260120809163643 3851 4419 3321 4368 4058 2477 3141 3987 4576 4329 3213 4406 M11505 GO_HISTONE_H2A_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_UBIQUITINATION.html The modification of histone H2A by addition of one or more ubiquitin groups. 15/20 Gene Ontology BP GO:0033522 0.0467635293729044 0.0529697650349829 4195 3924.54545454545 3987 0.004344378787147 3124 0.597695846060434 -0.411521427841144 -1 0.707930108149699 4195 4302 3238 3987 3786 3124 4261 3646 4557 4371 3703 4407 M16784 GO_DNA_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_ALKYLATION.html The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. 23/52 Gene Ontology BP GO:0006305 0.0839184282471183 0.0891201423493528 4500 3904.54545454545 3987 0.00793650793650794 3072 1.17700324311008 -0.748709504309276 -1 1.14721813440414 4497 4450 3167 4456 4163 3072 4129 3696 3429 3987 3904 4408 M10118 GO_ACYLGLYCEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. 14/41 Gene Ontology BP GO:0055090 0.000326353349446267 0.000453398743710059 4595 3801 3988 2.96728883229315e-05 2782 0.989351396189135 -1.0592325414552 -1 3.07060228801769 4595 3933 2782 4109 3210 4308 4111 4271 3988 3035 3469 4409 M11593 GO_TRIGLYCERIDE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. 14/41 Gene Ontology BP GO:0070328 0.000326353349446267 0.000453398743710059 4600 3802.09090909091 3989 2.96728883229315e-05 2783 0.989351396189135 -1.0592325414552 -1 3.07060228801769 4596 3934 2783 4110 3211 4309 4112 4270 3989 3039 3470 4410 M13105 GO_MATURATION_OF_LSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_LSU_RRNA.html Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. 7/17 Gene Ontology BP GO:0000470 0.916464257705497 0.922824452076908 3450 4012.90909090909 3991 0.219833615611689 3407 0.329569586722602 -0.329569586722602 -1 0.010670769407812 3448 4462 4014 3841 4374 3407 3991 3733 4637 4448 3787 4411 M13865 GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. 7/15 Gene Ontology BP GO:0051988 0.2542745383176 0.263408451898397 4420 3801.18181818182 3991 0.0289135434997371 2763 0.667488783361651 -0.656743992719487 -1 0.35897903988229 4420 3070 4148 2763 4012 3264 3900 3991 4276 4495 3474 4412 M16040 GO_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_PHOSPHORYLATION.html The modification of histones by addition of phosphate groups. 18/59 Gene Ontology BP GO:0016572 0.35943518917414 0.369543308975982 3225 3772.09090909091 3993 0.0396825396825397 2704 0.878081510197579 0.956970307444571 1 0.352390160971574 3224 3985 2704 3672 4086 4012 3471 3993 4280 4048 4018 4413 M10931 GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 30/61 Gene Ontology BP GO:0043647 0.0839184282471183 0.0891201423493528 3720 3822.90909090909 3994 0.00793650793650794 2374 1.13992030647474 -1.18582189087326 -1 1.11107360787506 3720 4335 2849 4587 4127 4268 2374 3526 3994 3784 4488 4414 M13210 GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. 9/17 Gene Ontology BP GO:2000303 0.00169521149849674 0.00218331955271022 4545 3777.72727272727 3995 0.000169650607252262 2337 0.968022802284197 -1.15641772561943 -1 2.39100465660888 4542 2337 4032 3002 3429 3786 4631 4005 3995 3751 4045 4415 M13028 GO_REGULATION_OF_HEXOKINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEXOKINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hexokinase activity. 5/14 Gene Ontology BP GO:1903299 0.972016813397458 0.974746018273089 3795 4085.18181818182 3996 0.300657829884276 3542 0.443198945692661 0.443198945692661 1 0.00456988304195628 3791 3913 3996 3542 4337 4256 3988 3824 4612 4443 4235 4416 M13431 GO_METHIONINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 8/16 Gene Ontology BP GO:0009086 0.00468808607382319 0.00578135023658992 3670 4036 3997 0.000469800570707071 3493 0.680329744701294 -0.626491201370914 -1 1.41332792187918 3667 3493 4075 3718 3568 4628 3889 3997 4340 4468 4553 4417 M12813 GO_CELL_REDOX_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_REDOX_HOMEOSTASIS.html Any process that maintains the redox environment of a cell or compartment within a cell. 35/76 Gene Ontology BP GO:0045454 0.0839184282471183 0.0891201423493528 4335 3699.54545454545 3999 0.00793650793650794 2420 1.5086407852477 -1.37331560903964 -1 1.47046335248674 4335 4368 2420 4538 3999 2618 4407 4281 3810 3142 2777 4418 M13456 GO_DNA_REPLICATION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INITIATION.html The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. 15/31 Gene Ontology BP GO:0006270 0.971189336678723 0.974547674562202 3095 3909.27272727273 3999 0.275631782251011 3094 0.428724180681131 -0.428724180681131 -1 0.00445579761099029 3095 4457 3094 3442 4368 3539 3909 3999 4611 4471 4017 4419 M10103 GO_REGULATION_OF_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GOLGI_ORGANIZATION.html Any process that modulates the frequency, rate or extent of Golgi organization. 7/19 Gene Ontology BP GO:1903358 0.435369722646862 0.446525651038078 4305 3973.54545454545 4003 0.0555555555555556 3101 0.664522554402306 -0.664522554402306 -1 0.215991688025625 4578 3101 3533 3716 4147 3724 4301 3995 4307 4304 4003 4420 M15463 GO_RECIPROCAL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_DNA_RECOMBINATION.html A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules. 23/42 Gene Ontology BP GO:0035825 0.625266237660124 0.636507595144915 4575 3946.09090909091 4003 0.0853656043162638 2901 0.423640781855426 -0.423640781855426 -1 0.0771537094755084 3698 4575 3163 4295 4206 2901 4003 3648 4629 4573 3716 4421 M16397 GO_RECIPROCAL_MEIOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_MEIOTIC_RECOMBINATION.html The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. 23/42 Gene Ontology BP GO:0007131 0.625266237660124 0.636507595144915 3700 3951.27272727273 4004 0.0853656043162638 2902 0.423640781855426 -0.423640781855426 -1 0.0771537094755084 3699 4576 3164 4296 4207 2902 4004 3650 4630 4619 3717 4422 M13031 GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. 16/36 Gene Ontology BP GO:0014742 0.127259738389055 0.134105076109938 3040 3719.54545454545 4005 0.0122980523965235 1973 1.19581872849386 -1.8156830586317 -1 0.968561284240367 3037 4580 2969 4543 4490 2976 1973 3939 4348 4005 4055 4423 M13065 GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT.html Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. 7/19 Gene Ontology BP GO:2000641 0.268943090789899 0.27835549945107 3590 3914.81818181818 4005 0.0308408093119267 2892 0.685532053659898 -0.482431456747664 -1 0.35342940929452 3589 3879 4005 3827 4343 4436 2980 2892 4463 4447 4202 4424 M13145 GO_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other. 68/132 Gene Ontology BP GO:0007062 0.909197801749093 0.915904836954012 3415 3988.72727272727 4006 0.195952904395352 3326 0.932869715594934 -0.946952583281239 -1 0.0330352794752893 3413 4554 3334 3943 4406 3326 4233 4006 4507 4237 3917 4425 M13619 GO_OXYGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORT.html The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/19 Gene Ontology BP GO:0015671 0.0765897756730953 0.0843068583333764 3980 4065.63636363636 4006 0.00793650793650794 3279 1.49912582466066 -0.780336948137207 -1 1.49474422218966 3976 3784 4106 3789 4353 4516 3839 4607 4006 3279 4467 4426 M11524 GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 9/20 Gene Ontology BP GO:0019370 0.0765897756730953 0.0843068583333764 4040 3896.36363636364 4007 0.00793650793650794 3149 1.84203342485072 1.84203342485072 1 1.8366496283995 4039 3645 3761 4179 4007 4203 4130 3149 3814 3741 4192 4427 M12247 GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. 5/14 Gene Ontology BP GO:0045898 0.815426880026028 0.823586470298205 4010 4047.27272727273 4007 0.155466570012613 3435 0.380353983170169 -0.380353983170169 -1 0.0297600936376526 4007 3998 3876 3543 4209 3435 4271 4310 4502 4403 3966 4428 M15074 GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 24/87 Gene Ontology BP GO:0002275 0.281709477500081 0.290855482328858 3985 3956.18181818182 4008 0.0296322017010616 3037 0.728489296827743 -0.78631135602356 -1 0.362675559357611 3983 4008 3119 3843 4014 4459 3037 3952 4272 4548 4283 4429 M15139 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY.html Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. 16/36 Gene Ontology BP GO:0010613 0.127259738389055 0.134105076109938 3040 3724.72727272727 4008 0.0122980523965235 1974 1.19581872849386 -1.8156830586317 -1 0.968561284240367 3038 4581 2970 4544 4491 2977 1974 3984 4349 4008 4056 4430 M13184 GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 9/16 Gene Ontology BP GO:0010870 0.0765897756730953 0.0843068583333764 3455 3781.27272727273 4010 0.00793650793650794 2940 1.18783610104061 -0.439718521492972 -1 1.18436428501629 3455 3703 4030 2940 4508 4184 4014 4382 4010 3079 3289 4431 M14364 GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 8/13 Gene Ontology BP GO:0009263 0.562604368603265 0.574103754598893 3450 3926.54545454545 4013 0.0793650793650794 3285 0.891553049943931 -1.04935237573788 -1 0.199457445893405 3447 4019 4230 4440 4376 3422 4013 3933 4372 3655 3285 4432 M14223 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. 6/28 Gene Ontology BP GO:0032695 0.0765897756730953 0.0843068583333764 4145 4011.81818181818 4015 0.00793650793650794 3364 1.3433637243196 1.3433637243196 1 1.33943735771745 4144 4149 4208 4486 4015 3364 4635 4009 3987 3446 3687 4433 M10379 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 7/25 Gene Ontology BP GO:1900153 0.27555016189509 0.285011922338351 4020 4019.09090909091 4020 0.0317202888234845 2912 0.267208690083834 -0.288648380078365 -1 0.135214947378431 4512 4020 3576 4263 4018 3969 4192 2912 4444 4315 3989 4434 M11084 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. 9/25 Gene Ontology BP GO:0034143 0.147859119791321 0.155108425935631 3770 3859.81818181818 4020 0.0158730158730159 2724 1.36846908369914 -1.58188673426127 -1 1.02813053290478 3770 3903 3686 4020 4093 4215 2724 4369 4150 3067 4461 4435 M12109 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 7/21 Gene Ontology BP GO:0060213 0.2093205118317 0.218349839684247 4515 4041.45454545455 4021 0.0232126035440068 2796 0.267208690083834 -0.288648380078365 -1 0.163915560648823 4513 4021 3851 4264 4019 3970 4193 2796 4445 4394 3990 4436 M12888 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 7/21 Gene Ontology BP GO:0060211 0.239518316676171 0.248621404946895 3975 4062.27272727273 4022 0.0270088819564693 2849 0.267208690083834 -0.288648380078365 -1 0.149929731258069 4514 4022 3975 4265 4020 3971 4194 2849 4446 4438 3991 4437 M11331 GO_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEPARATION.html The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). 14/21 Gene Ontology BP GO:0051304 0.698311849456277 0.708846068435832 3080 3851.81818181818 4028 0.103217522465002 2837 0.853085630094522 -0.853085630094522 -1 0.118345382353357 3079 4638 2837 4417 4323 2998 4028 3443 4580 4362 3665 4438 M11645 GO_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 20/62 Gene Ontology BP GO:0043330 0.0839184282471183 0.0891201423493528 3785 3990.72727272727 4028 0.00793650793650794 3032 0.984476099748943 1.14496288501687 1 0.959563027441729 3782 4196 3032 4359 4116 4028 3826 3948 4063 3913 4635 4439 M12685 GO_PROTEIN_K11_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K11_LINKED_UBIQUITINATION.html A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. 17/35 Gene Ontology BP GO:0070979 0.442052255859452 0.453279289742808 3915 3873.09090909091 4028 0.0516622299642927 2887 0.76878837894011 -0.849923761730737 -1 0.245229026671397 3911 4230 3172 4462 4563 2887 4395 3101 4473 4028 3382 4440 M16916 GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. 9/21 Gene Ontology BP GO:0046112 0.191722073230138 0.200397475463199 4540 4077.18181818182 4029 0.0210600056051003 3160 0.822573785960302 0.637327634218739 1 0.533047981363858 4538 3160 4637 3722 3970 4029 4585 3827 4330 3764 4287 4441 M12433 GO_RNA_SURVEILLANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SURVEILLANCE.html The set of processes involved in identifying and degrading defective or aberrant RNAs. 9/14 Gene Ontology BP GO:0071025 0.0765897756730953 0.0843068583333764 4280 4088.54545454545 4031 0.00793650793650794 3409 0.598590308160849 -0.510820554651856 -1 0.596840642902994 4277 3409 3907 4383 4579 3413 4007 4526 4031 4416 4026 4442 M14250 GO_DNA_REPLICATION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_CHECKPOINT.html A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. 8/15 Gene Ontology BP GO:0000076 0.971884108050661 0.974746018273089 3615 4087.54545454545 4032 0.300326884784557 3607 0.246326817302393 -0.302201658401445 -1 0.00253981788145193 3615 4314 4214 3681 4347 3607 4012 4032 4614 4508 4019 4443 M14518 GO_DNA_METHYLATION_OR_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_OR_DEMETHYLATION.html The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. 26/65 Gene Ontology BP GO:0044728 0.0839184282471183 0.0891201423493528 4380 3884.63636363636 4032 0.00793650793650794 2899 1.17700324311008 -0.748709504309276 -1 1.14721813440414 4376 4446 3244 4218 4512 2899 4455 3353 3570 4032 3626 4444 M11647 GO_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CONTRACTION.html A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. 22/55 Gene Ontology BP GO:0003009 0.0839184282471183 0.0891201423493528 4415 3535.09090909091 4034 0.00793650793650794 1495 2.22666158959487 -1.91957230595011 -1 2.1703141293108 4415 3746 1495 4244 4215 3285 4289 4109 2659 2395 4034 4445 M16660 GO_NUCLEAR_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 128/255 Gene Ontology BP GO:0098813 0.692016124577486 0.702608980190961 2930 3921.36363636364 4034 0.101532145268531 2928 0.835271103253146 -0.762373569803561 -1 0.118850005487713 2928 4544 3423 4431 4415 2993 4034 3888 4526 4275 3678 4446 M12238 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 4/21 Gene Ontology BP GO:0051589 0.0273334615069872 0.0315537697108259 4420 3879.45454545455 4035 0.00276756025877125 2754 0.710644061081929 -0.710644061081929 -1 0.990118207202839 4416 3137 3872 2754 3739 4316 4134 3640 4229 4402 4035 4447 M13249 GO_DNA_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEMETHYLATION.html The removal of a methyl group from one or more nucleotides within an DNA molecule. 3/14 Gene Ontology BP GO:0080111 0.832245759815318 0.840208102374978 4180 4031 4037 0.163497293172664 3573 0.3080204702859 -0.39556344330366 -1 0.0216193120251556 4176 3681 4037 3650 4223 3846 4450 3573 4501 4458 3746 4448 M16204 GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. 34/68 Gene Ontology BP GO:0008156 0.0839184282471183 0.0891201423493528 3650 3857.45454545455 4037 0.00793650793650794 2774 1.58932776133855 2.24694384500224 1 1.54910848721665 3650 4445 2774 4069 4118 4318 3876 2918 3612 4037 4615 4449 M11965 GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. 11/22 Gene Ontology BP GO:1903894 0.304112283835872 0.313428043029956 4040 3936.27272727273 4038 0.032423350220033 3034 0.941633782574858 0.941633782574858 1 0.440415613310264 4038 4236 3034 3319 4028 3633 4314 3153 4522 4388 4634 4450 M15690 GO_REGULATION_OF_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H4_ACETYLATION.html Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. 10/16 Gene Ontology BP GO:0090239 0.0839184282471183 0.0891201423493528 4140 3847.45454545455 4038 0.00793650793650794 2363 1.12827611599382 -1.34792499166774 -1 1.0997240819223 4136 4349 2768 3918 4242 4288 2363 4038 3953 3821 4446 4451 M12000 GO_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule. 22/83 Gene Ontology BP GO:0070988 0.161385165508919 0.168954075187804 3820 3853.27272727273 4040 0.0158730158730159 2487 0.687175418829344 -0.449273527812808 -1 0.492588189483701 3820 4380 3353 4418 4426 2487 4040 3631 4185 4391 3255 4452 M15475 GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the C-terminal amino acid residue in a protein. 8/16 Gene Ontology BP GO:0018410 0.00213407542854945 0.00271317420995484 4620 4092.27272727273 4040 0.000213612762787713 3460 0.644290077161112 -0.692020670049287 -1 1.53495473455752 4617 3804 4413 4392 3460 4019 3965 3670 4040 4575 4060 4453 M13289 GO_PROTEIN_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MANNOSYLATION.html The addition of a mannose residue to a protein acceptor molecule. 8/21 Gene Ontology BP GO:0035268 0.0765897756730953 0.0843068583333764 4375 3846.81818181818 4045 0.00793650793650794 2490 0.858111047816013 -0.866828471031667 -1 0.855602897990069 4373 2490 4045 3270 3957 4298 3968 4518 2828 4460 4108 4454 M14852 GO_MISMATCH_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR.html A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. 18/34 Gene Ontology BP GO:0006298 0.0839184282471183 0.0891201423493528 4400 3714.18181818182 4045 0.00793650793650794 1260 2.77302396929055 -0.460683679265589 -1 2.70285042010132 4396 4264 2718 3980 4578 3605 4141 3590 1260 4045 4279 4455 M12643 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. 8/15 Gene Ontology BP GO:0071459 0.971516841428327 0.974665664380234 4050 4012.45454545455 4048 0.299418258203502 3439 0.691041069495191 -0.691041069495191 -1 0.00714849630488018 3489 4110 3944 3439 4459 3603 4048 4050 4597 4426 3972 4456 M13328 GO_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_NUCLEAR_DIVISION.html A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. 222/475 Gene Ontology BP GO:0007067 0.161385165508919 0.168954075187804 3470 3943.18181818182 4051 0.0158730158730159 2797 0.966846793870392 -0.784718310746599 -1 0.693065199466631 3468 4605 3479 4566 4462 2797 4051 3842 4186 4286 3633 4457 M13695 GO_HISTONE_H4_K8_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K8_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. 11/16 Gene Ontology BP GO:0043982 0.0839184282471183 0.0891201423493528 3335 3736.18181818182 4051 0.00793650793650794 2685 0.513937006732257 -0.37497386476094 -1 0.500931261091689 3331 4386 3289 4051 4191 2685 2890 4404 4103 4485 3283 4458 M14479 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition. 17/33 Gene Ontology BP GO:1902750 0.298735036746822 0.308022823809792 4040 4022.81818181818 4052 0.0317460317460317 2903 1.37311275176076 1.81193153787152 1 0.651854178429938 4040 4266 2903 3752 4159 4052 4414 4001 4246 3778 4640 4459 M14977 GO_HISTONE_H4_K5_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K5_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. 11/16 Gene Ontology BP GO:0043981 0.0839184282471183 0.0891201423493528 3335 3742.54545454545 4052 0.00793650793650794 2686 0.513937006732257 -0.37497386476094 -1 0.500931261091689 3332 4387 3290 4052 4192 2686 2891 4407 4104 4543 3284 4460 M10610 GO_NEGATIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. 35/78 Gene Ontology BP GO:0051782 0.0839184282471183 0.0891201423493528 4155 4031.72727272727 4053 0.00793650793650794 2761 1.46346100717058 1.82182833999156 1 1.42642688085169 4152 4443 2761 4053 4478 3833 4035 4351 3682 4050 4511 4461 M13377 GO_GRANULOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_ACTIVATION.html The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 11/32 Gene Ontology BP GO:0036230 0.00627739571646609 0.00764784789072476 4360 4004.09090909091 4053 0.000572307207008085 3026 0.616654588889598 -0.689062002425705 -1 1.21149397158016 4360 3801 3026 4336 3592 4004 3971 4053 4225 4464 4213 4462 M11286 GO_PROTEIN_NEDDYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_NEDDYLATION.html Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. 7/16 Gene Ontology BP GO:0045116 0.147859119791321 0.155108425935631 3655 4006.54545454545 4054 0.0158730158730159 3537 1.02788829713402 1.02788829713402 1 0.772252209312211 3654 3537 3725 3880 4324 4488 4515 4054 4125 3550 4220 4463 M14726 GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT.html The directed movement of substances from early endosomes to the Golgi. 11/16 Gene Ontology BP GO:0034498 0.419840419791359 0.430788744550559 4020 3903 4054 0.0482906954476935 2806 0.748844619092629 -0.748844619092629 -1 0.254230589971359 4020 4204 3210 4054 4576 2806 4472 3563 4416 4533 3079 4464 M13342 GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. 8/24 Gene Ontology BP GO:0031272 0.0765897756730953 0.0843068583333764 4010 4075.09090909091 4055 0.00793650793650794 3258 2.77204231200345 2.77204231200345 1 2.76394043841501 4010 4392 4055 4490 4638 4570 3258 3550 3685 3650 4528 4465 M15083 GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 28/59 Gene Ontology BP GO:0051784 0.0839184282471183 0.0891201423493528 3905 3836.81818181818 4058 0.00793650793650794 2723 1.67846429206628 1.99257282863592 1 1.63598935458918 3902 4101 2723 3478 4346 4127 4094 4047 2995 4058 4334 4466 M16063 GO_PEPTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 9/24 Gene Ontology BP GO:0043171 0.00173218648957771 0.00222846823804636 4480 3785 4058 0.000173353818420753 2933 1.26673187049069 -0.979081093310683 -1 3.11836017183698 4476 2933 4503 3339 3431 3040 4280 4058 4230 3093 4252 4467 M13792 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. 80/189 Gene Ontology BP GO:1903747 0.00911848690179393 0.0109795473768229 4460 3754 4059 0.000832409243125752 2053 1.44886042351954 2.07040305461441 1 2.63525236282117 4456 4548 3150 4154 3629 2053 3973 4059 2944 4122 4206 4468 M15760 GO_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 360/808 Gene Ontology BP GO:0010564 0.0561787421871177 0.0631874757690861 4060 3761.90909090909 4060 0.00524243533842154 1822 1.30578221300219 -1.09590191011504 -1 1.4537597718224 4060 4600 3384 3771 4544 1822 4097 4143 3475 4242 3243 4469 M12317 GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. 67/140 Gene Ontology BP GO:0007006 0.0839184282471183 0.0891201423493528 4125 3799.45454545455 4061 0.00793650793650794 2739 1.31561759116108 -0.900018689292979 -1 1.28232474771552 4124 4363 3273 4294 4061 2739 4096 3252 3438 4030 4124 4470 M12388 GO_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MEMBRANE.html The process of directing proteins towards a membrane, usually using signals contained within the protein. 100/285 Gene Ontology BP GO:0006612 0.0839184282471183 0.0891201423493528 3490 3942.45454545455 4062 0.00793650793650794 2762 1.22817673098768 -0.858772821198431 -1 1.19709664074701 4185 4434 3490 4002 4062 2762 4480 4327 3490 4245 3890 4471 M11049 GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. 77/173 Gene Ontology BP GO:0045931 0.0839184282471183 0.0891201423493528 3630 3921.90909090909 4063 0.00793650793650794 2873 1.28662494021247 -1.18814595628199 -1 1.25406577643541 3627 4616 2873 4156 4359 4070 3232 3874 4005 4063 4266 4472 M14109 GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. 78/183 Gene Ontology BP GO:0072331 4.91526038618645e-08 1.94060833104283e-07 4435 3610.63636363636 4063 4.46841863273059e-09 1078 1.40135093304747 -1.2386541462211 -1 8.7311611820977 4069 4435 2890 4142 1078 2986 4542 4063 3065 4013 4434 4473 M16564 GO_RNA_INTERFERENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_INTERFERENCE.html The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. 4/12 Gene Ontology BP GO:0016246 0.570356708549291 0.581758830798409 4360 4027.45454545455 4063 0.0810099621878408 3259 0.19424883348128 -0.298925634950592 -1 0.0424197454212018 4358 4063 4582 3740 4569 3378 3603 3259 4506 4630 3614 4474 M14998 GO_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 33/99 Gene Ontology BP GO:0051225 0.698707235477011 0.70909239220104 3590 3973.63636363636 4066 0.103324431975744 3000 0.730227314964682 -0.56252673740258 -1 0.10119939799087 3588 4499 3227 4424 4637 3000 4057 4066 4453 4182 3577 4475 M15090 GO_REGULATION_OF_CHOLESTEROL_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_STORAGE.html Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 9/23 Gene Ontology BP GO:0010885 0.0765897756730953 0.0843068583333764 4260 3961.27272727273 4068 0.00793650793650794 3153 1.90135216915445 1.90135216915445 1 1.89579500562585 3153 3966 4348 3817 4137 4083 3726 4260 4068 3756 4260 4476 M13379 GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 6/15 Gene Ontology BP GO:0009113 0.00391373929193386 0.0048612871943416 4630 3964 4069 0.000392064923563981 2868 0.822573785960302 0.637327634218739 1 1.76630739823483 4627 2868 4063 3518 3540 4069 4603 4085 4352 3435 4444 4477 M11531 GO_BLASTOCYST_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_FORMATION.html The initial formation of a blastocyst from a solid ball of cells known as a morula. 13/34 Gene Ontology BP GO:0001825 6.02789537076315e-05 9.13728965277614e-05 3465 3830 4070 5.48005503505934e-06 2834 0.825898216266071 0.670688349741132 1 3.09662866356804 3465 4132 2834 3902 2952 4455 4071 4070 4161 3934 4154 4478 M10723 GO_MEMBRANE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DISASSEMBLY.html The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. 28/57 Gene Ontology BP GO:0030397 0.0839184282471183 0.0891201423493528 3605 3856.09090909091 4075 0.00793650793650794 2970 1.45118586597148 -1.85140898805718 -1 1.41446237083776 3604 4630 3055 4291 4466 3385 4221 2970 4075 4145 3575 4479 M13452 GO_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that modulates the amount of sodium excreted in urine over a unit of time. 8/27 Gene Ontology BP GO:0035813 0.0011342636228229 0.00148348901430048 4140 3605.27272727273 4076 0.000113484298834797 2113 3.82922814775975 -3.83257846248176 -1 10.0547128378293 4139 3068 4076 2405 3380 4574 4279 4397 2113 2924 4303 4480 M15629 GO_NUCLEAR_ENVELOPE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_DISASSEMBLY.html The controlled breakdown of the nuclear envelope in the context of a normal process. 28/57 Gene Ontology BP GO:0051081 0.0839184282471183 0.0891201423493528 3605 3855.90909090909 4076 0.00793650793650794 2957 1.45118586597148 -1.85140898805718 -1 1.41446237083776 3605 4631 3056 4292 4467 3386 4222 2957 4076 4147 3576 4481 M13459 GO_ERYTHROCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. 5/16 Gene Ontology BP GO:0043249 0.236800584081119 0.245910335917834 3860 4125.90909090909 4078 0.0266617221475029 3679 0.613928369603466 0.613928369603466 1 0.347186664370737 3859 3679 4078 3731 4004 4617 4065 4262 4418 4472 4200 4482 M15791 GO_RRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. 13/28 Gene Ontology BP GO:0000154 0.878859116702268 0.886303839888929 4085 4100.27272727273 4082 0.174603174603175 3187 0.684015646120212 -0.684015646120212 -1 0.033281871326685 4082 4307 3187 4361 4315 3734 4078 4012 4479 4591 3957 4483 M16295 GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. 14/20 Gene Ontology BP GO:0000028 0.232850105696956 0.241861977796636 4445 3946 4082 0.0238095238095238 3191 0.373927580207424 -0.373927580207424 -1 0.213964481157028 4444 4173 3408 3191 4082 3504 4010 4133 4227 4614 3620 4484 M16175 GO_IMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. 4/11 Gene Ontology BP GO:0006188 0.0399652802680491 0.0455247292160333 3005 3902.81818181818 4085 0.0040702767557709 2513 0.662328864708037 0.662328864708037 1 0.824926342126604 3005 4085 4524 4389 3777 3161 2513 4357 4503 4606 4011 4485 M16707 GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 4/13 Gene Ontology BP GO:0051533 0.147859119791321 0.155108425935631 4080 3959.45454545455 4086 0.0158730158730159 3070 1.59486697271216 -1.59486697271216 -1 1.19822325272552 4078 4086 4608 3070 4599 4177 4642 3176 4113 3128 3877 4486 M14586 GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. 7/27 Gene Ontology BP GO:0051580 0.147859119791321 0.155108425935631 4560 4043.54545454545 4087 0.0158730158730159 3414 1.37607614472097 -1.37607614472097 -1 1.03384571737353 4559 3705 4253 3668 4027 4543 3414 4501 4153 3569 4087 4487 M15131 GO_HISTONE_H4_K16_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K16_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. 13/21 Gene Ontology BP GO:0043984 0.0839184282471183 0.0891201423493528 4090 4037.36363636364 4087 0.00793650793650794 3258 0.513937006732257 -0.37497386476094 -1 0.500931261091689 4087 4271 3319 4056 4504 3258 3761 4642 4102 4553 3858 4488 M10037 GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that activates or increases the frequency, rate or extent of viral transcription. 22/51 Gene Ontology BP GO:0050434 0.0839184282471183 0.0891201423493528 4090 3975.18181818182 4088 0.00793650793650794 3203 1.21270515786781 0.876672634246854 1 1.18201658679722 4088 4227 3292 4038 4114 4349 3203 4205 3824 3962 4425 4489 M16081 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. 26/60 Gene Ontology BP GO:1904356 0.20266161564125 0.211641448812939 4575 3856.18181818182 4093 0.0203782370320127 2292 0.77145969038307 -0.712873210288539 -1 0.482946798806853 4093 4573 3294 3937 4538 2292 3274 4170 4571 4601 3075 4490 M16321 GO_GLUCOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. 20/52 Gene Ontology BP GO:0006007 0.232850105696956 0.241861977796636 4095 3866 4095 0.0238095238095238 2672 1.19523519111042 -1.0676718734344 -1 0.683923996275155 4095 4503 3011 4223 4278 2672 4340 3703 4214 3916 3571 4491 M14810 GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. 39/107 Gene Ontology BP GO:0048024 0.244378154735725 0.253552574846474 3485 3817.90909090909 4096 0.0251522959386009 2388 1.05210161251755 -0.713492519197231 -1 0.582000509055712 3483 4563 3377 4235 4361 2388 3581 4096 4412 4209 3292 4492 M11148 GO_OXIDATIVE_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. 5/41 Gene Ontology BP GO:0070989 0.214139132665174 0.222875586855952 3470 3881.54545454545 4097 0.0238095238095238 3255 0.92507730984588 0.92507730984588 1 0.55982588560253 3470 3255 3699 3341 4097 4190 4185 3797 4198 4350 4115 4493 M16090 GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. 9/32 Gene Ontology BP GO:1902187 5.24299896003731e-05 8.01819636740883e-05 4520 4016 4098 5.24312266481645e-06 2945 0.953771749326483 -1.05134057719691 -1 3.62631385336282 4519 3587 4506 3711 2945 4098 4031 4472 4146 3759 4402 4494 M15192 GO_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 34/99 Gene Ontology BP GO:0043331 0.0642993642836658 0.0720419759577848 4195 3942.72727272727 4100 0.00602357484471591 3073 0.970991825511285 -0.755849794322121 -1 1.02969426186034 4193 4560 3280 3379 3832 3073 4160 4586 4171 4036 4100 4495 M13742 GO_MITOTIC_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. 39/105 Gene Ontology BP GO:0007052 0.0839184282471183 0.0891201423493528 3020 3934 4101 0.00793650793650794 3016 1.1457940516987 -0.735251667035944 -1 1.11679871379535 3016 4562 3203 4369 4405 4373 3092 3760 4101 4094 4299 4496 M13783 GO_VIRAL_LIFE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LIFE_CYCLE.html A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. 184/480 Gene Ontology BP GO:0019058 0.0839184282471183 0.0891201423493528 4105 3890.54545454545 4101 0.00793650793650794 2737 1.3510081372354 -0.935857340958629 -1 1.31681971083133 3882 4540 3427 3381 4560 2737 4101 4104 3517 4165 4382 4497 M12565 GO_ORGANELLE_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FISSION.html The creation of two or more organelles by division of one organelle. 284/735 Gene Ontology BP GO:0048285 0.0839184282471183 0.0891201423493528 4105 3929.36363636364 4103 0.00793650793650794 2673 0.969304316184904 -0.772687842016807 -1 0.944775176659671 3512 4603 3488 4567 4545 2673 4103 3776 4105 4295 3556 4498 M13303 GO_TRANSEPITHELIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSEPITHELIAL_TRANSPORT.html The directed movement of a substance from one side of an epithelium to the other. 6/18 Gene Ontology BP GO:0070633 0.00534720536394181 0.00655933276216164 4105 3928.72727272727 4103 0.000536011577971652 2954 0.860309694238512 -0.742743977986827 -1 1.74343420387142 4103 3463 4048 3294 3585 4310 4412 2954 4156 4461 4430 4499 M15720 GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 6/17 Gene Ontology BP GO:0002283 0.00381421908024083 0.00474274750657691 4605 4047.09090909091 4104 0.000382078165906971 3134 0.460397250041576 -0.448954738265769 -1 0.993189891343734 4602 3134 4447 4029 3538 3565 4361 3850 4301 4587 4104 4500 M13816 GO_NEGATIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BEHAVIOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 5/21 Gene Ontology BP GO:0048521 0.0765897756730953 0.0843068583333764 4285 3688.45454545455 4105 0.00793650793650794 2279 1.79827891003404 -1.19306608944343 -1 1.79302299208809 4285 2644 4136 3784 4105 4321 3378 4221 2863 2279 4557 4501 M14751 GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. 9/19 Gene Ontology BP GO:0071071 0.640661047585957 0.651607720469135 3605 4022.45454545455 4105 0.0972854765240759 2974 1.04641466939113 -1.04641466939113 -1 0.180683122193404 3601 4590 4286 4362 4595 2974 3979 4105 4625 3754 3376 4502 M16675 GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 95/214 Gene Ontology BP GO:0035966 0.00439820702120385 0.00543397424147138 4160 3660.81818181818 4105 0.000400638594511943 1051 0.986723744185047 -0.882269342269754 -1 2.07448519760929 4159 4035 3409 4506 4628 1051 4196 4265 3796 4105 2119 4503 M15571 GO_RESPONSE_TO_SALT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. 7/19 Gene Ontology BP GO:1902074 0.0831585436952187 0.0891201423493528 4330 4026.90909090909 4109 0.00864449120995293 2752 1.42565640390478 -1.55681215778553 -1 1.38957894997989 4326 4109 4425 3888 3869 4050 4220 3844 4317 2752 4496 4504 M10182 GO_CYTOKINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 6/19 Gene Ontology BP GO:0042107 0.0102750595850956 0.0123178677132969 3240 3822.63636363636 4112 0.00103228806595143 1881 0.359900814556347 0.367219963981473 1 0.637915880062757 3236 4396 3551 4591 4526 3949 2991 1881 4509 4307 4112 4505 M10769 GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. 74/160 Gene Ontology BP GO:0042787 0.0839184282471183 0.0891201423493528 4220 3887.72727272727 4112 0.00793650793650794 3042 1.25073028933282 -0.904323324513667 -1 1.21907946524517 4220 4551 3293 3685 4112 3042 4169 4203 3241 4227 4022 4506 M11930 GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. 6/29 Gene Ontology BP GO:0045947 0.752131607823278 0.761812184800062 4115 4075.36363636364 4113 0.13019456914291 3383 0.234873543499911 -0.282223135562382 -1 0.0257597234350834 4584 4111 3827 3544 4178 3383 4113 3942 4578 4385 4184 4507 M13676 GO_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the cell cycle. 560/1342 Gene Ontology BP GO:0051726 9.33634196923159e-09 6.62823176806457e-08 3995 3578.09090909091 4113 9.33634200845688e-10 498 1.34328403662562 -1.10263143915515 -1 8.95110972099676 3992 4526 4113 4304 498 2049 4225 4300 3373 4156 3823 4508 M15019 GO_NUCLEAR_ENVELOPE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. 50/100 Gene Ontology BP GO:0006998 0.00380382022627161 0.00473235190529987 4435 3936.81818181818 4116 0.000346401184597346 3128 1.25724802150274 -1.01125689856533 -1 2.71330514536593 4434 4555 3128 4413 3523 3171 4564 3502 3625 4116 4274 4509 M12040 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. 88/246 Gene Ontology BP GO:0070972 0.0989072309684713 0.104774417838606 4120 3792.90909090909 4117 0.00942323535518453 2013 0.705018555128617 -0.589621762947822 -1 0.641183729757061 4117 4436 3504 3772 4276 2013 3608 4379 4396 4281 2940 4510 M13159 GO_CARNITINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARNITINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. 6/16 Gene Ontology BP GO:0009437 0.0765897756730953 0.0843068583333764 4610 4167.63636363636 4122 0.00793650793650794 3433 1.08621300184363 -1.25158119720057 -1 1.08303819311285 4608 4313 4025 4549 4503 3958 3922 4492 3919 3433 4122 4511 M13729 GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. 6/24 Gene Ontology BP GO:0042753 0.0765897756730953 0.0843068583333764 4595 4132.54545454545 4122 0.00793650793650794 3305 0.869396880725913 -0.617610109363877 -1 0.866855746522259 4592 3305 4122 4439 4385 4104 4511 4117 4087 3438 4358 4512 M15516 GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION.html Any process that modulates the frequency, rate or extent of interferon-gamma secretion. 6/15 Gene Ontology BP GO:1902713 0.00186727017052054 0.00239231109319174 1885 3204.90909090909 4123 0.000186884104260951 865 0.612017545210521 0.721620598887403 1 1.48912169064505 1884 4281 4416 4123 4381 2135 865 1501 4402 4577 2689 4513 M16908 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 3/32 Gene Ontology BP GO:0032225 0.973411028095464 0.975933362869194 4635 4182.18181818182 4125 0.304222861982336 3668 0.185656707718948 -0.185656707718948 -1 0.00182309845168148 3746 4284 4635 4125 4513 3668 3931 3908 4634 4640 3920 4514 M16313 GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. 9/18 Gene Ontology BP GO:1903209 0.147859119791321 0.155108425935631 4525 4092.54545454545 4126 0.0158730158730159 3369 1.15954374482992 -0.568048229897021 -1 0.871164938911579 4523 4273 4546 4126 3995 3978 4558 3369 4142 3761 3747 4515 M11845 GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 75/171 Gene Ontology BP GO:0035967 0.0123078524822192 0.0146526561730625 4415 3724.27272727273 4130 0.00112520478820495 1341 0.851750614402275 -0.70502201205312 -1 1.45010908670128 4411 3467 3433 4556 4130 1341 4212 4488 3977 4173 2779 4516 M13765 GO_REGULATION_OF_GROWTH_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. 5/17 Gene Ontology BP GO:0060123 0.742829351267896 0.752718611509568 4445 4019.09090909091 4131 0.126984126984127 3066 0.325796148313848 0.314732632429445 1 0.0373089421261696 3961 3677 4131 3066 4443 4456 3494 3739 4443 4489 4311 4517 M16619 GO_NUCLEOTIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SALVAGE.html Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. 8/14 Gene Ontology BP GO:0043173 0.000119546031388911 0.000173943034703452 4185 3952.09090909091 4131 1.19552462939995e-05 2373 0.813367137838072 -0.942850808708764 -1 2.83855007620196 4182 2373 4593 4086 3072 4614 4637 4299 3822 3664 4131 4518 M13021 GO_LYSOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_LOCALIZATION.html Any process in which a lysosome is transported to, and/or maintained in, a specific location. 15/47 Gene Ontology BP GO:0032418 0.514011397665828 0.526252462924463 4115 4042 4132 0.0634920634920635 2809 0.578631536489735 -0.578631536489735 -1 0.14975197067255 4114 3986 2809 4132 4452 4496 3591 3879 4337 4442 4224 4519 M11004 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 5/18 Gene Ontology BP GO:0060261 0.0633654692467666 0.0710127621802407 4135 3843.54545454545 4133 0.0065248317068164 2993 0.604227060652858 -0.380353983170169 -1 0.644261282938543 4133 2993 3670 3005 3846 4251 4296 3073 4133 4345 4534 4520 M13409 GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. 2/12 Gene Ontology BP GO:0070897 0.00601664775229997 0.00733980439146841 4580 4022 4133 0.00067031087539481 2811 0.360608865872168 -0.358367786762868 -1 0.714437166793117 4576 2811 4070 NA 3609 3975 3559 4609 4196 4466 4349 4521 M16816 GO_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_SPLICING.html Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 59/150 Gene Ontology BP GO:0043484 0.112969099145101 0.119316543978777 4105 3895.81818181818 4136 0.0108386035055278 2068 1.09775321076275 -0.701908698519711 -1 0.94084111235072 4102 4622 3418 4298 4472 2068 3997 4136 4268 4203 3270 4522 M11209 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html The directed movement of a protein to a specific location in the endoplasmic reticulum. 71/216 Gene Ontology BP GO:0072599 0.317414517404371 0.326992590261481 4140 3838.72727272727 4137 0.0341195674233668 2528 0.594213945661407 -0.540788128747265 -1 0.26777311549485 4137 4437 3500 3561 4153 2528 3605 4545 4347 4352 3061 4523 M11124 GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that activates or increases the frequency, rate or extent of viral genome replication. 20/50 Gene Ontology BP GO:0045070 0.46565726771514 0.477378382424685 3995 3901.36363636364 4138 0.0553816993502487 2870 0.954666137306041 -0.707287848456931 -1 0.284584364257119 3993 4296 2962 4138 4435 2870 4153 4445 4413 4074 3136 4524 M15953 GO_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXECUTION_PHASE_OF_APOPTOSIS.html A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. 32/76 Gene Ontology BP GO:0097194 0.00323394020462367 0.00405049483951112 4145 3844.90909090909 4141 0.000294427619549357 2627 1.02876672951553 -1.06397017837343 -1 2.28473846463435 4141 4444 3063 4281 3504 2627 4318 4615 4223 3624 3454 4525 M12629 GO_TELOMERE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_LOCALIZATION.html Any process in which a telomere is transported to, and/or maintained in, a specific location. 5/12 Gene Ontology BP GO:0034397 0.932189169062675 0.938251530881855 4145 4107.72727272727 4145 0.23593570289749 3352 0.160752780196285 -0.225923847996612 -1 0.00413031860772539 4145 4353 3941 3983 4505 3543 3352 4294 4622 4424 4023 4526 M12154 GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. 10/32 Gene Ontology BP GO:0048026 0.290311000758494 0.299469890362516 3735 3853 4148 0.0306943729176204 2484 0.245740376100544 -0.234569034698788 -1 0.119449243527402 3734 4640 3043 4148 4541 2484 3155 4280 4618 4397 3343 4527 M12575 GO_REGULATION_OF_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_SILENCING.html Any process that affects the rate, extent or location of chromatin silencing. 12/33 Gene Ontology BP GO:0031935 0.850621352955467 0.858572813428746 4150 4098.54545454545 4148 0.158730158730159 3156 0.597763298437309 -0.506548232228639 -1 0.036745483090779 4148 4456 3156 3615 4360 4081 4110 3778 4471 4423 4486 4528 M10298 GO_REGULATION_OF_RNA_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_STABILITY.html Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. 92/186 Gene Ontology BP GO:0043487 0.0839184282471183 0.0891201423493528 4010 3946.09090909091 4151 0.00793650793650794 2674 1.26581588185128 -0.982879926646757 -1 1.2337833061074 4006 4547 3419 4159 4416 2674 4334 4520 3732 4151 3449 4529 M13502 GO_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SUMOYLATION.html The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. 71/158 Gene Ontology BP GO:0016925 0.0839184282471183 0.0891201423493528 4310 4012.54545454545 4152 0.00793650793650794 2983 1.35153216290224 -1.1259435935172 -1 1.31733047565569 4307 4621 3239 4300 4375 2983 4618 4019 3921 4152 3603 4530 M10569 GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 20/50 Gene Ontology BP GO:0090329 0.989778913686225 0.991273402986441 4335 4147.90909090909 4155 0.340757516347248 3145 1.11242630096685 1.11242630096685 1 0.00393051066841248 4332 4504 3145 4155 4493 3690 4595 3949 4563 4073 4128 4531 M13612 GO_MEIOTIC_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEPARATION.html The process in which chromosomes are physically detached from each other during meiosis. 8/12 Gene Ontology BP GO:0051307 0.967814177670512 0.971370779706915 4160 4206.90909090909 4156 0.290803700305037 3586 0.270988091698664 -0.288499597201148 -1 0.00317305420746371 4156 4591 4104 3758 4424 3586 4627 3831 4638 4481 4080 4532 M13413 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G1_S_PHASE_TRANSITION.html The cell cycle process by which a cell in G1 phase commits to S phase. 65/140 Gene Ontology BP GO:0044843 0.0839184282471183 0.0891201423493528 4365 4080.27272727273 4160 0.00793650793650794 3271 1.14091874968446 -0.849268222827576 -1 1.11204678476869 4361 4492 3271 3767 4245 3612 4612 4160 4054 4191 4118 4533 M11699 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT.html Any process that modulates the frequency, rate or extent of cellular response to heat. 53/95 Gene Ontology BP GO:1900034 0.0839184282471183 0.0891201423493528 3305 4059.54545454545 4161 0.00793650793650794 3232 1.18959535013071 1.12042986131395 1 1.15949158919388 3302 4438 3232 4475 4283 4393 3671 4161 4004 4086 4610 4534 M14382 GO_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE.html Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. 95/350 Gene Ontology BP GO:0051321 0.0839184282471183 0.0891201423493528 2970 3994.72727272727 4166 0.00793650793650794 2969 1.40648616075995 1.90509679623075 1 1.37089382348274 2969 4615 3048 4301 4268 4346 3728 4129 3961 4166 4411 4535 M13759 GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of a protein along a microtubule, mediated by motor proteins. 19/44 Gene Ontology BP GO:0098840 0.0839184282471183 0.0891201423493528 4525 3862.36363636364 4168 0.00793650793650794 2442 1.05364964213324 -0.92928326458303 -1 1.02698608410001 3411 4168 3096 4525 4248 4277 2442 4352 3914 3528 4525 4536 M14407 GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. 65/140 Gene Ontology BP GO:0000082 0.0839184282471183 0.0891201423493528 4365 4081.90909090909 4168 0.00793650793650794 3272 1.14091874968446 -0.849268222827576 -1 1.11204678476869 4362 4493 3272 3768 4246 3613 4613 4168 4055 4192 4119 4537 M16836 GO_INTRACILIARY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT.html The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. 19/44 Gene Ontology BP GO:0042073 0.0839184282471183 0.0891201423493528 4530 3862.09090909091 4169 0.00793650793650794 2443 1.05364964213324 -0.92928326458303 -1 1.02698608410001 3412 4169 3097 4526 4249 4278 2443 4338 3915 3530 4526 4538 M13851 GO_METHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 9/21 Gene Ontology BP GO:0006555 0.581427416937915 0.59266026275362 3745 4217.81818181818 4174 0.0834058569443975 3743 0.680329744701294 -0.626491201370914 -1 0.143477964511517 3743 3852 4144 4196 4120 4607 4174 4055 4411 4493 4601 4539 M14133 GO_TOXIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_TRANSPORT.html The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/59 Gene Ontology BP GO:1901998 0.0125974279085736 0.0149820332427016 4505 3774.45454545455 4174 0.00115183142757769 1919 1.06423706194804 -0.893669789687127 -1 1.80233076976652 4503 4565 2951 4283 4559 2727 4350 1919 4174 3705 3783 4540 M16418 GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 13/30 Gene Ontology BP GO:0051984 0.726270090971166 0.7364210597028 4560 4128 4174 0.111111111111111 3017 0.667488783361651 -0.656743992719487 -1 0.0823287260624008 4556 4174 3017 4460 4519 3637 4059 3887 4430 4621 4048 4541 M15433 GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification. 22/71 Gene Ontology BP GO:1903309 0.0839184282471183 0.0891201423493528 4100 4181.27272727273 4175 0.00793650793650794 3344 0.70643445288603 -0.686441211834816 -1 0.688557422355714 4310 4572 3344 4287 4636 4015 4075 4383 4097 4100 4175 4542 M14955 GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM.html A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). 10/21 Gene Ontology BP GO:0034975 0.184776763296018 0.193311967549214 4465 3918.09090909091 4176 0.0184007185078929 2249 0.260590952356155 -0.249711362699931 -1 0.172650867550639 4464 4018 3082 2958 4614 2249 4176 4554 4604 4541 3839 4543 M13885 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE.html A process of chromosome organization that is involved in a meiotic cell cycle. 20/56 Gene Ontology BP GO:0070192 0.78350570796374 0.792380091935448 4385 4118 4177 0.12986619604569 3241 0.711515515664781 -0.511060123013746 -1 0.0667512154151687 4384 4298 3241 4580 4177 3526 4571 3845 4496 4077 4103 4544 M14993 GO_MEIOTIC_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE_PROCESS.html A process that is part of the meiotic cell cycle. 76/298 Gene Ontology BP GO:1903046 0.0839184282471183 0.0891201423493528 2945 4012.54545454545 4178 0.00793650793650794 2941 1.46455952436347 2.04391850300033 1 1.42749759928511 2941 4619 2979 4428 4334 4421 3704 4114 4029 4178 4391 4545 M11691 GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. 12/19 Gene Ontology BP GO:2000104 0.572929286103103 0.58425448613589 3410 4013.27272727273 4180 0.0744304213651913 2732 1.11242630096685 1.11242630096685 1 0.241011102631298 3410 4639 3071 4575 4594 4051 2732 4467 4532 3895 4180 4546 M16661 GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS.html Any process that alters the size or shape of an auditory receptor cell. 8/25 Gene Ontology BP GO:0002093 0.76527490244494 0.77444886051697 3975 4230.45454545455 4181 0.134920634920635 3871 0.400186417248359 -0.347883561100333 -1 0.0412363960663482 3971 4143 4598 4351 4394 3871 4181 4020 4455 4633 3918 4547 M10661 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. 6/23 Gene Ontology BP GO:0051818 0.278830811075077 0.287947387860672 3355 4060.63636363636 4182 0.0321596674778787 3354 0.956236661165351 0.956236661165351 1 0.479932500229931 3354 4182 3615 4445 4022 4440 3476 4461 4394 4323 3955 4548 M11527 GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. 3/16 Gene Ontology BP GO:2000400 0.18769940521067 0.196281157295752 4430 3849.36363636364 4183 0.0205738907634671 2699 1.19306608944343 -1.19306608944343 -1 0.783118539791389 4428 3105 3762 2699 3965 4463 4183 4246 4260 2849 4383 4549 M10789 GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 7/25 Gene Ontology BP GO:0002281 0.214139132665174 0.222875586855952 3655 3876.81818181818 4189 0.0238095238095238 3001 0.98081006321927 -0.98081006321927 -1 0.593553498467875 3651 4279 3635 4453 4474 3001 4189 3285 4224 4330 3124 4550 M14395 GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. 2/11 Gene Ontology BP GO:0045741 0.929280684998797 0.93552693418244 4150 4220.1 4191 0.254974918022496 3722 0.174896305115381 -0.174896305115381 -1 0.00469877932029728 4149 4114 4233 NA 4428 3948 4335 3722 4606 4519 4147 4551 M10434 GO_MRNA_SPLICE_SITE_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_SPLICE_SITE_SELECTION.html Selection of a splice site by components of the assembling spliceosome. 15/42 Gene Ontology BP GO:0006376 0.514011397665828 0.526252462924463 4395 4071.63636363636 4192 0.0634920634920635 3177 1.81499225586142 -1.81499225586142 -1 0.469727109562757 4393 4584 3177 4510 4468 3983 3553 4192 4334 3992 3602 4552 M14150 GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The regulation of blood pressure mediated by detection of stimuli and a neurological response. 6/22 Gene Ontology BP GO:0001976 0.0765897756730953 0.0843068583333764 4505 3829.90909090909 4192 0.00793650793650794 1728 4.53762937542826 -4.53762937542826 -1 4.52436733412835 4505 4024 4192 3661 4277 4420 4623 3016 1728 3444 4239 4553 M10241 GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 8/21 Gene Ontology BP GO:0051532 0.214139132665174 0.222875586855952 4370 3970.18181818182 4195 0.0238095238095238 3363 1.59486697271216 -1.59486697271216 -1 0.965160362781802 4368 4275 3558 3683 4333 4369 3567 3363 4195 3635 4326 4554 M15172 GO_ESTROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 5/23 Gene Ontology BP GO:0006703 0.963050259283485 0.967007429466528 4550 4220.36363636364 4195 0.280946607676564 3722 0.290517038785892 -0.307806487405514 -1 0.00392901248194342 4547 4151 4367 4045 4619 3764 3722 4195 4572 4557 3885 4555 M16889 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 7/25 Gene Ontology BP GO:1900151 0.202807030741131 0.211745681072875 4025 4134.72727272727 4195 0.0224109103782492 2780 0.267208690083834 -0.288648380078365 -1 0.167223981419815 4515 4023 4632 4266 4021 3972 4195 2780 4447 4639 3992 4556 M15208 GO__DE_NOVO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_PROTEIN_FOLDING.html The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. 13/33 Gene Ontology BP GO:0006458 0.721042506805127 0.731280113389297 4200 4169.18181818182 4196 0.109581106618828 3137 0.584999239239211 0.584999239239211 1 0.0738064955957521 4196 4509 3137 4146 4156 3985 4441 3777 4587 4559 4368 4557 M16773 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. 2/23 Gene Ontology BP GO:0014857 0.00156813988284277 0.00202584125654952 4585 3837.4 4200.5 0.000174359319989654 1882 1.15547486740105 -1.40823202626166 -1 2.88888064008082 4583 1882 4617 NA 3433 4364 4019 4485 4109 2590 4292 4558 M14187 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE.html The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. 7/15 Gene Ontology BP GO:1990126 0.205069939536945 0.213963984105626 4205 4222 4203 0.0226887635346536 3711 0.741757306678501 -0.749929740687383 -1 0.461088938157903 4203 4082 4200 4400 3977 3915 3711 4358 4519 4504 4573 4559 M16147 GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS.html The process in which the structure of the atrioventricular valve is generated and organized. 9/26 Gene Ontology BP GO:0003181 0.214139132665174 0.222875586855952 2940 3969.90909090909 4206 0.0238095238095238 2937 0.68974608898113 0.68974608898113 1 0.417411240137606 2937 3994 4518 4206 4386 3596 2940 4507 4226 4605 3754 4560 M11161 GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL.html Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 4/21 Gene Ontology BP GO:0045760 0.214139132665174 0.222875586855952 4480 4094.81818181818 4208 0.0238095238095238 3110 1.31259556379598 -1.31259556379598 -1 0.794339073205499 4477 3734 3700 3640 4234 4473 4639 4628 4200 3110 4208 4561 M11946 GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. 6/11 Gene Ontology BP GO:0033262 0.947121885976207 0.952043064859824 4125 4164.18181818182 4211 0.254706050196973 3538 0.303178968530001 -0.340355198106661 -1 0.00600644082251394 4121 4211 3832 4276 4470 3538 4491 4086 4570 4386 3825 4562 M12072 GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. 20/57 Gene Ontology BP GO:0031057 0.0839184282471183 0.0891201423493528 4215 4152.36363636364 4214 0.00793650793650794 3310 0.70643445288603 -0.686441211834816 -1 0.688557422355714 4214 4452 3310 4222 4616 4179 3829 4437 4096 4075 4246 4563 M15695 GO_REGULATION_OF_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_COHESION.html Any process that modulates the frequency, rate or extent of sister chromatid cohesion. 11/21 Gene Ontology BP GO:0007063 0.232850105696956 0.241861977796636 3740 3917.27272727273 4214 0.0238095238095238 2393 1.55112493926463 1.55112493926463 1 0.887567273480605 3737 4514 2937 4214 4548 4394 2393 3851 4228 3866 4408 4564 M16727 GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. 9/19 Gene Ontology BP GO:0006515 0.00133217672834781 0.00173257606434703 3050 3374.36363636364 4215 0.00013329760154743 1286 0.457438553763565 -0.457438553763565 -1 1.17251021230347 3048 4459 4612 4215 4590 1426 1490 2755 4601 4636 1286 4565 M10086 GO_MEIOTIC_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. 29/69 Gene Ontology BP GO:0045132 0.85857463161967 0.866223818907025 3825 4171.18181818182 4221 0.162904107754056 3160 1.04975115888804 1.22811806322721 1 0.0607755567418225 3824 4569 3160 4601 4221 4361 3915 4077 4491 4069 4595 4566 M13719 GO_MALE_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS_I.html A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. 11/129 Gene Ontology BP GO:0007141 0.908853417764908 0.915756601276577 3955 4064.81818181818 4222 0.195676154258542 2926 0.328010257887439 -0.241238484964365 -1 0.0116369450361199 3952 4389 2926 3989 4255 4222 3272 4023 4613 4486 4586 4567 M10662 GO_IRON_COORDINATION_ENTITY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_COORDINATION_ENTITY_TRANSPORT.html The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 4/13 Gene Ontology BP GO:1901678 0.685292826051428 0.695934949990547 4600 4102.27272727273 4223 0.109178553111102 3371 0.544642102909819 -0.544642102909819 -1 0.0795921923662778 4598 3680 3616 3960 4258 4124 4545 3371 4426 4324 4223 4568 M13842 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. 16/25 Gene Ontology BP GO:0090083 0.0839184282471183 0.0891201423493528 4520 3822.09090909091 4229 0.00793650793650794 2535 1.71235677313653 -1.11362986462925 -1 1.66902416230214 4520 4229 2535 3490 4351 3263 4238 4381 2932 3729 4375 4569 M11281 GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. 27/77 Gene Ontology BP GO:1903313 0.0290960869594376 0.0335468417563121 3395 3654.63636363636 4233 0.00268074330866374 1608 0.672436411050189 -0.813244542253592 -1 0.920280836560615 3394 4571 3342 4372 4233 1608 2619 4470 4554 4357 2681 4570 M16642 GO_SYNAPSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSIS.html The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. 13/41 Gene Ontology BP GO:0007129 0.557443745451391 0.569212955823798 4165 4158.18181818182 4237 0.0714285714285714 3118 0.902721825588275 -0.693017350209701 -1 0.205069648531539 4165 4237 3118 4592 4275 4338 4146 4074 4371 3946 4478 4571 M11753 GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. 10/36 Gene Ontology BP GO:0060122 0.63389956273523 0.645013296028856 3960 4097 4239 0.0873015873015873 2901 0.867995824892017 -0.867995824892017 -1 0.153435060396309 3959 4239 2901 4404 4642 3661 4445 4202 4391 4377 3846 4572 M14284 GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 9/38 Gene Ontology BP GO:0060117 0.742829351267896 0.752718611509568 4235 4301.45454545455 4240 0.126984126984127 4084 0.367243958530839 -0.347883561100333 -1 0.0420554144553676 4235 4240 4217 4407 4580 4157 4275 4164 4448 4509 4084 4573 M11992 GO_REGULATION_OF_CENTRIOLE_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTRIOLE_REPLICATION.html Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. 9/18 Gene Ontology BP GO:0046599 0.0353451423582194 0.040450455008433 4375 3980.45454545455 4243 0.00359202340272077 2238 0.397256247604204 -0.397256247604204 -1 0.513706072734106 4375 4243 3840 4137 4325 3485 4326 2238 4619 4390 3807 4574 M14711 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization. 7/22 Gene Ontology BP GO:0031116 0.0765897756730953 0.0843068583333764 4190 4087.09090909091 4244 0.00793650793650794 3315 1.25084851854578 1.25084851854578 1 1.24719254018307 4186 4244 4278 3315 3905 4269 4386 4484 3791 3570 4530 4575 M15036 GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. 3/16 Gene Ontology BP GO:0033089 0.18769940521067 0.196281157295752 4430 3903.54545454545 4248 0.0205738907634671 2700 1.19306608944343 -1.19306608944343 -1 0.783118539791389 4429 3106 4337 2700 3966 4464 4184 4248 4261 2860 4384 4576 M11278 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY.html Any process that increases the activity of triglyceride lipase. 3/15 Gene Ontology BP GO:0061365 0.995738886031923 0.996382682725478 4250 4234.81818181818 4250 0.420634920634921 3722 0.195213046145496 -0.238475416890497 -1 0.000284986961409938 4250 4185 3722 4258 4404 4071 4247 4417 4579 4356 4094 4577 M14122 GO_PROTEIN_K48_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. 13/28 Gene Ontology BP GO:0071108 0.80434346180892 0.812922658506491 4280 4052 4250 0.13783498342613 3015 0.794812099980959 -0.794812099980959 -1 0.066364705184061 4280 3962 3115 4448 4286 4011 3015 4187 4516 4502 4250 4578 M14217 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. 9/16 Gene Ontology BP GO:1904814 0.263614916734419 0.272962546475894 3025 3825.90909090909 4250 0.0301367614516536 2473 0.712873210288539 -0.712873210288539 -1 0.373147843692701 3025 4351 4207 4450 4314 2473 2705 4250 4551 4506 3253 4579 M13802 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. 55/128 Gene Ontology BP GO:2001251 0.807360195845509 0.815793991144875 4245 4085.63636363636 4251 0.139052019532173 3164 0.656074614162902 -0.590531707994713 -1 0.0538479006004472 4242 4556 3434 4302 4477 3164 4424 3998 4495 4251 3599 4580 M14367 GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING.html The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. 12/28 Gene Ontology BP GO:0051084 0.753105012427053 0.762631749770732 4015 4178.45454545455 4251 0.1194098099909 3113 0.584999239239211 0.584999239239211 1 0.0639064371606442 4011 4510 3113 4286 4166 4142 4251 3883 4583 4514 4504 4581 M15562 GO_PROTEIN_REFOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_REFOLDING.html The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. 17/28 Gene Ontology BP GO:0042026 0.966484997128523 0.970246452252483 4405 4123.27272727273 4253 0.265603088283068 3225 0.584999239239211 0.584999239239211 1 0.00712323941175878 4401 4422 3225 3932 4445 3518 4253 3828 4598 4578 4156 4582 M16726 GO_PHAGOCYTOSIS_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_RECOGNITION.html The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. 6/130 Gene Ontology BP GO:0006910 0.742829351267896 0.752718611509568 4335 4206.72727272727 4257 0.126984126984127 3464 1.04291378532163 -1.04291378532163 -1 0.119430989178052 4334 3911 4611 4257 4390 4253 4164 3967 4442 3464 4481 4583 M10990 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. 4/12 Gene Ontology BP GO:0090220 0.955630906970874 0.960180545567143 4260 4154.54545454545 4258 0.267667926442033 3521 0.153015730306284 -0.243035282116773 -1 0.0025063584585261 4258 4398 3668 4128 4553 3521 3783 4422 4615 4342 4012 4584 M16317 GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS.html The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. 7/16 Gene Ontology BP GO:0071428 0.769018083285452 0.77806732636617 3695 4170.81818181818 4259 0.136310185311052 3009 0.117287127060637 0.119276080440599 1 0.0118650637677411 3695 4464 4547 3844 4444 4259 3009 4116 4639 4615 4247 4585 M10604 GO_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION.html The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. 272/718 Gene Ontology BP GO:0051301 0.0839184282471183 0.0891201423493528 4195 4131.09090909091 4260 0.00793650793650794 3276 1.28739635922006 -0.924037288918397 -1 1.25481767413593 4192 4602 3329 4518 4260 3276 4597 4363 3751 4219 4335 4586 M13603 GO_PARTURITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARTURITION.html The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. 4/26 Gene Ontology BP GO:0007567 0.987478019489479 0.989182404420637 4645 4246 4272 0.354691623801659 3822 0.275211872254946 -0.275211872254946 -1 0.00120652867255878 4272 4643 4102 3837 4567 3822 4304 3899 4641 4480 4139 4587 M16540 GO_THYROID_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. 8/35 Gene Ontology BP GO:0030878 0.275742742869669 0.285011922338351 4580 4032.45454545455 4272 0.0317460317460317 2245 0.673725218655047 -0.596537758914796 -1 0.340923803185753 4612 2245 4576 2494 4357 4082 4263 4577 4250 4629 4272 4588 M14706 GO_RRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an rRNA molecule. 7/14 Gene Ontology BP GO:0031125 0.562604368603265 0.574103754598893 4535 4097 4276 0.0793650793650794 3109 0.524313106562879 -0.524313106562879 -1 0.117298772314188 4217 3618 4276 4531 4549 3109 3464 4521 4377 4531 3874 4589 M11073 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. 8/18 Gene Ontology BP GO:0002204 0.33296556889208 0.342632787315143 4245 4203.45454545455 4277 0.0396825396825397 3684 0.631812587178997 -0.631812587178997 -1 0.272815975921702 4244 4140 3684 4260 4520 4327 3752 4317 4277 4347 4370 4590 M13836 GO_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOTYPE_SWITCHING.html The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 8/18 Gene Ontology BP GO:0045190 0.33296556889208 0.342632787315143 4145 4256.18181818182 4278 0.0396825396825397 3753 0.631812587178997 -0.631812587178997 -1 0.272815975921702 4245 4141 4142 4261 4521 4328 3753 4287 4278 4491 4371 4591 M16318 GO_MITOTIC_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. 8/13 Gene Ontology BP GO:0007064 0.938021636224195 0.943917307539865 4560 4203.27272727273 4278 0.242776627126433 3465 0.233368592753276 -0.228769346815146 -1 0.00542976653136177 4560 4278 4548 3919 4358 3465 4139 3736 4636 4616 3981 4592 M11032 GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 7/16 Gene Ontology BP GO:0071545 0.302371538623778 0.311703164704752 4405 4163.81818181818 4279 0.0353663247203394 3607 0.614331425000703 -0.614331425000703 -1 0.288698244028202 4404 4463 3673 4279 4039 3843 3607 4166 4617 4346 4365 4593 M14018 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE.html The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. 8/18 Gene Ontology BP GO:0002208 0.33296556889208 0.342632787315143 4250 4259.81818181818 4279 0.0396825396825397 3754 0.631812587178997 -0.631812587178997 -1 0.272815975921702 4246 4142 4171 4262 4522 4329 3754 4282 4279 4499 4372 4594 M16550 GO_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PROCESS.html The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. 626/1538 Gene Ontology BP GO:0022402 0.0765897756730953 0.0843068583333764 4400 4156.18181818182 4280 0.00793650793650794 2807 1.26582396487487 -0.970544082240371 -1 1.2621242187387 4397 4596 4578 4005 4643 2807 4526 4259 3774 4280 3853 4595 M10606 GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 13/39 Gene Ontology BP GO:0061013 0.147443143879905 0.154952131515256 3710 3727.54545454545 4281 0.0143967592003636 2252 0.813244542253592 -0.813244542253592 -1 0.611320892658394 3710 4348 3179 4461 4281 2252 2990 4342 4485 4320 2635 4596 M13544 GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. 21/62 Gene Ontology BP GO:0000381 0.514011397665828 0.526252462924463 3995 4211.45454545455 4281 0.0634920634920635 3268 1.39071070583787 1.39071070583787 1 0.359921333812839 3991 4635 3268 4579 4299 4281 4098 4279 4338 4090 4468 4597 M14734 GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 9/18 Gene Ontology BP GO:0009219 0.210550916803462 0.219534674762738 3030 3746.90909090909 4284 0.0233647115121797 2349 0.471259757294478 -0.471259757294478 -1 0.288059968047365 3030 4589 4284 4537 4420 2349 2852 3142 4530 4534 2949 4598 M10625 GO_POSITIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RNA_SPLICING.html Any process that activates or increases the frequency, rate or extent of RNA splicing. 14/44 Gene Ontology BP GO:0033120 0.238757537121031 0.247887129886616 3675 3839.81818181818 4288 0.024495304541686 2369 0.626084966781134 -0.626084966781134 -1 0.352040587072067 3674 4583 3125 4288 4534 2369 3340 4373 4555 4321 3076 4599 M14987 GO_PRE_MIRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MIRNA_PROCESSING.html Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. 4/13 Gene Ontology BP GO:0031054 0.950890490373012 0.955624360779631 4635 4237 4289 0.260196196555598 3729 0.18489270387603 -0.280213375740092 -1 0.00338306848879922 4632 4283 4332 3745 4312 4110 4084 3729 4547 4544 4289 4600 M14947 GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. 18/50 Gene Ontology BP GO:0045143 0.91119225863579 0.917714893025157 4295 4219.72727272727 4292 0.197574686767938 3208 0.902721825588275 -0.693017350209701 -1 0.0312491704680662 4292 4454 3208 4581 4257 4305 4291 4082 4513 4046 4388 4601 M11466 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING.html Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. 12/21 Gene Ontology BP GO:0000469 0.764920450698206 0.774427748057516 4370 4080.45454545455 4294 0.123326833797314 3053 0.570919009938468 -0.570919009938468 -1 0.0588355505932117 4070 4511 3053 4411 4294 3096 4370 4269 4565 4367 3879 4602 M10472 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. 9/16 Gene Ontology BP GO:0032211 0.814680562148455 0.82301171672221 3675 4095.27272727273 4296 0.155125704305709 3069 0.705791890019587 -0.522951129467041 -1 0.0554221892078737 3673 4424 3591 4144 4296 4121 3069 4304 4599 4317 4510 4603 M13382 GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. 8/19 Gene Ontology BP GO:0007095 0.598881260040338 0.61018338608016 4600 4127.36363636364 4303 0.0873015873015873 3297 1.03131439250307 -0.495475179539245 -1 0.205384327161471 4600 3762 4064 3297 4303 3581 4632 4630 4390 3651 4491 4604 M15180 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 19/31 Gene Ontology BP GO:0032205 0.944432313346934 0.949750753924586 4510 4177.54545454545 4306 0.231059142056499 3182 0.593124815758991 -0.49462220415461 -1 0.0123273292472365 4506 4299 3182 4151 4306 3712 4594 4328 4542 4558 3775 4605 M15166 GO_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. 160/378 Gene Ontology BP GO:0033044 0.0839184282471183 0.0891201423493528 4535 3989 4307 0.00793650793650794 2609 1.2108150449547 -1.07849855469764 -1 1.1801743045367 4531 4608 3375 4307 4328 2609 4487 4344 3832 4197 3261 4606 M12195 GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. 13/31 Gene Ontology BP GO:0070193 0.865412014258462 0.872932431501638 3440 4079.63636363636 4308 0.166666666666667 3126 1.11242630096685 1.11242630096685 1 0.0609443592569878 3440 4308 3126 4576 4523 4639 3496 4034 4477 3937 4320 4607 M14912 GO_TETRAHYDROFOLATE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_INTERCONVERSION.html The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. 6/13 Gene Ontology BP GO:0035999 0.351951568446546 0.3619293759241 4210 4240.45454545455 4315 0.0424515747543578 3539 0.481683169101187 -0.481683169101187 -1 0.197350868975754 4207 3539 4315 3883 4060 4330 4629 4108 4511 4539 4524 4608 M15129 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 3/21 Gene Ontology BP GO:0033139 0.534200027008845 0.546319543040103 4270 4186.45454545455 4316 0.073554351245509 3214 0.323151709505006 -0.448254393665765 -1 0.0787574954321139 4268 4316 4358 4047 4430 3895 4497 3214 4481 4552 3993 4609 M15888 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 3/21 Gene Ontology BP GO:0033141 0.529333454930554 0.541461826667232 4270 4201 4317 0.0725909427541041 3207 0.323151709505006 -0.448254393665765 -1 0.0799210408268914 4269 4317 4475 4048 4431 3896 4498 3207 4482 4594 3994 4610 M10549 GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION.html Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. 7/14 Gene Ontology BP GO:1901970 0.0238842190650116 0.0277097524035105 4625 4039.09090909091 4319 0.00241448758414981 2118 0.22399979170814 -0.160978225725164 -1 0.323822894317063 4624 4520 3601 4408 4554 3955 3515 2118 4631 4319 4185 4611 M10647 GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. 7/14 Gene Ontology BP GO:0045842 0.0288750036140827 0.0333084824298599 4625 4046.54545454545 4322 0.00292572065636764 2176 0.22399979170814 -0.160978225725164 -1 0.307204686248329 4625 4521 3614 4409 4555 3956 3516 2176 4632 4322 4186 4612 M10353 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. 9/23 Gene Ontology BP GO:0033962 0.514224749016284 0.526354830176942 4330 4124.72727272727 4328 0.0696560484735125 3219 0.266349193152754 -0.248031160754342 -1 0.068911156406741 4328 4461 3571 4060 4454 3219 4533 4619 4593 4313 3221 4613 M10699 GO_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CONDENSATION.html The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. 16/40 Gene Ontology BP GO:0030261 0.945980760404871 0.951101920866136 4290 4239.09090909091 4328 0.233032196123306 2923 0.526649286078539 0.54320241440786 1 0.0106438666134757 4288 4507 2923 4147 4279 4340 4299 4433 4628 4328 4458 4614 M14208 GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 9/24 Gene Ontology BP GO:0002381 0.632427457617131 0.643656441410859 3770 4123.72727272727 4331 0.0952380952380952 3171 0.631812587178997 -0.631812587178997 -1 0.112221415672588 3769 4139 4203 4345 4331 4396 3171 3546 4406 4505 4550 4615 M15037 GO_ORGANELLE_INHERITANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INHERITANCE.html The partitioning of organelles between daughter cells at cell division. 9/16 Gene Ontology BP GO:0048308 0.519561398625271 0.531582982330792 3525 4042.09090909091 4338 0.0706831976622917 2704 0.204014688302707 0.20451635534851 1 0.0519707241255719 3521 4391 4338 3842 4597 3420 2704 4512 4624 4546 3968 4616 M10992 GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. 12/16 Gene Ontology BP GO:0045910 0.239865821978421 0.2489264665726 3810 4043.27272727273 4343 0.0246245016062275 2812 0.25831682885095 -0.204904220952018 -1 0.144812837151134 3808 4586 3206 4507 4217 4583 3301 2812 4553 4343 4560 4617 M16056 GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. 53/124 Gene Ontology BP GO:0048524 0.0839184282471183 0.0891201423493528 4345 3803.27272727273 4343 0.00793650793650794 2367 1.39681108944548 -1.16182744324447 -1 1.36146358673435 4343 4366 2933 4447 4429 2367 4463 4374 3532 3929 2653 4618 M16780 GO_MITOTIC_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CHROMOSOME_CONDENSATION.html The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. 10/15 Gene Ontology BP GO:0007076 0.883739596958266 0.89103212783436 4350 4255.63636363636 4347 0.177683022538904 2992 0.526649286078539 0.54320241440786 1 0.0244952726154754 4347 4137 2992 4492 4238 4209 4322 4426 4528 4637 4484 4619 M14138 GO_REGULATION_OF_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. 6/19 Gene Ontology BP GO:0033127 0.76527490244494 0.77444886051697 4350 4223.72727272727 4348 0.134920634920635 3429 0.587725859007199 0.587725859007199 1 0.0605611122492078 3802 4180 4190 3429 4348 4531 4349 4372 4457 4503 4300 4620 M11137 GO_POLYOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 11/24 Gene Ontology BP GO:0046174 0.712149691925757 0.722576708831138 4465 4038.54545454545 4349 0.107037263173992 2877 0.677893196067789 -0.677893196067789 -1 0.0887985358697829 4465 4587 2981 4539 4190 3404 2877 4418 4608 4349 4006 4621 M11284 GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. 5/16 Gene Ontology BP GO:0043922 0.517264715415336 0.529349806848889 4390 4253.27272727273 4358 0.0702399008932313 3724 0.205374079702246 -0.191438790592068 -1 0.0526655666880473 4051 4427 3724 4274 4103 4387 3895 4387 4610 4358 4570 4622 M14218 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. 39/67 Gene Ontology BP GO:0000288 0.642617547609388 0.653454505814802 3910 4108.45454545455 4368 0.0892991378917212 2925 0.578568655022456 -0.58837281755578 -1 0.0992405189693439 3908 4628 3444 4583 4533 2925 4368 4319 4497 4507 3481 4623 M11670 GO_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_PRODUCTION.html The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 11/37 Gene Ontology BP GO:0032612 0.466738071388703 0.47838076500171 3575 4162.18181818182 4374 0.0555555555555556 2766 0.425947835508192 -0.322321006699535 -1 0.126614033400864 3574 4517 2766 4508 4423 4202 4245 4449 4328 4374 4398 4624 M15234 GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. 6/23 Gene Ontology BP GO:0051883 0.278830811075077 0.287947387860672 3355 4151.81818181818 4374 0.0321596674778787 3355 0.956236661165351 0.956236661165351 1 0.479932500229931 3355 4183 4374 4446 4023 4441 3477 4460 4395 4560 3956 4625 M14695 GO_HISTONE_H2A_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_ACETYLATION.html The modification of histone H2A by the addition of an acetyl group. 12/18 Gene Ontology BP GO:0043968 0.891073518496821 0.898036541432763 4380 4176.18181818182 4377 0.182539682539683 3339 0.418472248558595 -0.418472248558595 -1 0.0181427668383822 4377 4585 3339 3924 4480 3648 4521 3914 4487 4530 4133 4626 M15325 GO_COENZYME_A_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 6/11 Gene Ontology BP GO:0015937 0.416526975299923 0.427483365675849 4245 4095.63636363636 4378 0.052450125909836 2679 0.639644411402157 0.639644411402157 1 0.219143592905121 4243 3831 4387 4395 4532 2679 3677 4436 4378 4567 3927 4627 M16419 GO_RRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. 9/20 Gene Ontology BP GO:0031167 0.942782599431097 0.948297142365377 4565 4326.63636363636 4378 0.248804785896982 3390 0.568958323777506 -0.568958323777506 -1 0.0121763736531178 4620 4395 4562 4280 4378 4311 3390 4353 4561 4622 4121 4628 M11745 GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. 11/25 Gene Ontology BP GO:0044818 0.891073518496821 0.898036541432763 4620 4064.54545454545 4391 0.182539682539683 2884 1.03131439250307 -0.495475179539245 -1 0.0447126937798488 4619 4207 2884 3127 4391 3775 4416 4513 4483 3855 4440 4629 M14460 GO_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE.html The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. 744/1842 Gene Ontology BP GO:0007049 0.0765897756730953 0.0843068583333764 4605 4215.09090909091 4411 0.00793650793650794 2944 1.27076983184627 -0.984012282804909 -1 1.26705563074292 4601 4595 4238 4477 4527 2944 4604 4411 3746 4284 3939 4630 M12435 GO_MITOTIC_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis. 20/58 Gene Ontology BP GO:0090307 0.995466716848964 0.996325062800116 4425 4262.72727272727 4425 0.387724865505376 3220 0.555475123248156 -0.555475123248156 -1 0.000824251616504269 4425 4578 3220 4473 4583 3850 4255 4494 4568 4417 4027 4631 M11926 GO_INTRA_S_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_S_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. 6/13 Gene Ontology BP GO:0031573 0.99757458836727 0.998004484763895 4075 4380 4426 0.452380952380952 3826 0.231950568928312 0.177973227756227 1 0.00018657924198203 4072 4426 3826 4406 4498 4629 4114 4643 4589 4383 4594 4632 M15903 GO_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 939/2159 Gene Ontology BP GO:0033554 1.25297975532604e-08 7.81933468276719e-08 4590 3559.90909090909 4428 1.25297976239085e-09 605 1.44541900736859 -1.15832538551102 -1 9.53539818808477 4590 4428 4477 4582 605 1353 4624 4462 2888 4053 3097 4633 M12271 GO_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOSIS_I.html The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. 44/204 Gene Ontology BP GO:0007127 0.956860614316309 0.961000180028255 4610 4211.72727272727 4429 0.248554250227637 3315 0.66318130372185 -0.513432971306851 -1 0.0106352972874649 4606 4561 3315 4429 4600 3480 4522 3868 4621 4231 4096 4634 M13474 GO_RNA_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DESTABILIZATION.html Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. 8/23 Gene Ontology BP GO:0050779 0.974058538794575 0.976371717535236 4285 4329.18181818182 4430 0.305936120379017 3535 0.574637850184293 -0.574637850184293 -1 0.00553918550381268 4284 4523 4083 4226 4408 4430 3535 4575 4607 4473 4477 4635 M12787 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. 9/20 Gene Ontology BP GO:0000466 0.99967295139151 0.999888305323305 4230 4334.45454545455 4432 0.551810961589469 3960 0.574048493591306 -0.574048493591306 -1 2.56460161479825e-05 4228 4460 3960 4463 4609 4116 4018 4290 4620 4432 4483 4636 M13041 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. 12/21 Gene Ontology BP GO:1904357 0.95587185006586 0.960214842028514 3965 4186.27272727273 4444 0.247004573890369 2948 0.705791890019587 -0.522951129467041 -1 0.0115512639203233 3962 4518 2948 4066 4409 4576 3387 4639 4595 4444 4505 4637 M15715 GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. 7/14 Gene Ontology BP GO:1902101 0.0432788493258645 0.0491545248091949 4630 4158.72727272727 4446 0.00441455792584238 2306 0.22399979170814 -0.160978225725164 -1 0.27206274855988 4626 4522 4446 4410 4556 3957 3517 2306 4633 4586 4187 4638 M13120 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS.html Any microtubule cytoskeleton organization that is involved in mitosis. 20/58 Gene Ontology BP GO:1902850 0.995466716848964 0.996325062800116 4430 4266.72727272727 4450 0.387724865505376 3221 0.555475123248156 -0.555475123248156 -1 0.000824251616504269 4426 4579 3221 4474 4584 3851 4256 4496 4569 4450 4028 4639 M15633 GO_FOREBRAIN_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. 2/14 Gene Ontology BP GO:0021877 0.788934193620593 0.797522634657177 4340 4321.8 4451.5 0.158730158730159 2995 0.88202239114554 -0.400256186801117 -1 0.0804472260889449 4338 2995 4434 NA 4622 4569 4403 4214 4469 4581 4593 4640 M11414 GO_DNA_INTEGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRATION.html The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. 2/7 Gene Ontology BP GO:0015074 0.999983277087056 0.999983277087056 4595 4386.9 4461.5 0.705383625407153 3741 0.0302413341015999 0.0302413341015999 1 0 4140 4593 3741 NA 4593 4479 4444 4341 4643 4364 4531 4641 M14619 GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. 17/32 Gene Ontology BP GO:0000289 0.341363171745924 0.351196367475365 3870 3993.72727272727 4475 0.037250562109646 2593 0.56189700880339 -0.574637850184293 -1 0.237034511245359 3866 4506 3371 4513 4585 2593 3892 4626 4475 4526 2978 4642 M16035 GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION.html Any process that modulates the frequency, rate or extent of protein polyubiquitination. 8/20 Gene Ontology BP GO:1902914 0.539313306734431 0.551427369118689 4560 4227.09090909091 4509 0.0745764081157209 2733 0.184276315102138 0.181532968125732 1 0.0442198060091317 3525 4642 4497 4509 4557 3907 2733 4558 4640 4599 4331 4643 M16444 GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that activates or increases the frequency, rate or extent of gluconeogenesis. 4/18 Gene Ontology BP GO:0045722 0.994365263811796 0.99565191284843 4190 4382.90909090909 4530 0.404218026383288 3734 0.0604839229261107 0.0444907897115687 1 0.000106048225379628 4188 4592 4567 3840 4506 4530 3734 4378 4642 4624 4611