Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M12305 GO_HEMIDESMOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMIDESMOSOME_ASSEMBLY.html Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. 13/25 Gene Ontology BP GO:0031581 1.13950183044588e-08 2.27068969903872e-07 5 103.545454545455 25 1.03591076031636e-09 1 2.83358068766313 2.83358068766313 1 22.3014428786184 1 309 230 1 232 3 2 28 25 290 18 2 M16608 GO_POSITIVE_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELINATION.html Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 8/16 Gene Ontology BP GO:0031643 2.63427464895274e-09 6.33727315807646e-08 35 535.454545454545 34 2.63427465207547e-10 4 3.46472014868952 3.46472014868952 1 29.543637642673 36 477 4591 34 35 23 13 4 10 663 4 3 M13905 GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a neurophysiological process. 14/34 Gene Ontology BP GO:0031646 1.30268072206383e-08 2.55204497575628e-07 10 170 44 1.18425520888852e-09 3 3.16045098538614 3.16045098538614 1 24.684115135324 9 461 450 53 173 10 3 6 44 655 6 4 M15056 GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. 31/101 Gene Ontology BP GO:0042475 2.75517876910954e-09 6.56015129485927e-08 125 101.818181818182 46 2.50470797505453e-10 1 2.53072931139677 2.8489378565549 1 21.5345022432545 123 110 333 35 19 46 38 1 72 299 44 5 M13801 GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 264/821 Gene Ontology BP GO:0000904 4.79702036505159e-22 1.23736475305192e-19 20 152.363636363636 49 4.36092760459236e-23 6 1.83731089514046 1.96252425776022 1 41.1523741316183 49 17 17 6 168 40 259 140 847 30 103 6 M14840 GO_STRIATED_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_PROLIFERATION.html The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. 13/29 Gene Ontology BP GO:0014855 3.02242059904426e-07 2.2381337865012e-06 65 169.181818181818 53 2.74765546752074e-08 10 2.21108689252229 2.32595409587689 1 14.7992964415425 65 154 614 29 439 33 17 37 53 410 10 7 M11549 GO_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_PROLIFERATION.html The expansion of a muscle cell population by cell division. 14/33 Gene Ontology BP GO:0033002 1.92331132970842e-07 1.75506689760962e-06 40 208.909090909091 55 1.74846499804596e-08 5 2.21108689252229 2.32595409587689 1 15.0758736839689 91 152 716 36 682 37 5 45 55 472 7 8 M16906 GO_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS.html The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. 56/161 Gene Ontology BP GO:0042476 8.13628642404801e-15 5.03690371558066e-13 30 57.2727272727273 56 7.39662402186184e-16 7 2.48299002753716 2.62092304264242 1 36.172769943324 26 77 70 18 62 15 30 7 175 94 56 9 M13894 GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. 36/71 Gene Ontology BP GO:0034446 1.05748546006649e-07 1.27201868213151e-06 10 159.090909090909 57 9.61350464452e-09 6 1.93907566008495 2.00030737028089 1 13.5423466357997 10 101 369 57 386 6 21 19 508 256 17 10 M14224 GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. 39/74 Gene Ontology BP GO:0007044 2.88315232516912e-09 6.82983481926541e-08 25 131.181818181818 57 2.6210475717705e-10 2 2.3664669750731 2.58699443133456 1 20.08771122181 21 270 225 12 277 22 57 2 143 402 12 11 M10925 GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of neuron differentiation. 181/480 Gene Ontology BP GO:0045666 2.98609631570359e-12 1.136429933919e-10 30 141.727272727273 60 2.71463301427967e-13 20 1.88950503744757 2.05022612609472 1 22.2590800737739 106 28 113 31 185 28 252 60 678 58 20 12 M13718 GO_CARDIAC_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 82/191 Gene Ontology BP GO:0003231 2.88550080441987e-13 1.31346865048249e-11 60 122.909090909091 60 2.62318254947294e-14 38 2.15196046832546 2.23876645840803 1 27.7398644880957 38 57 95 48 59 60 215 230 416 75 59 13 M16018 GO_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. 131/386 Gene Ontology BP GO:0042692 5.07488655134113e-17 5.1223257082341e-15 45 144.818181818182 68 4.61353322849193e-18 27 2.30158668542301 2.46665885402808 1 38.9631302966809 44 39 44 27 105 31 126 264 633 68 212 14 M10489 GO_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 85/264 Gene Ontology BP GO:0050808 5.67271250765182e-16 4.248129705327e-14 15 87.1818181818182 69 5.15701137059256e-17 14 1.95675936568146 2.1399749444476 1 30.9959851422178 14 53 57 14 109 69 164 121 212 45 101 15 M10077 GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. 29/69 Gene Ontology BP GO:0007528 9.61102328601321e-09 1.96581414612156e-07 5 140.636363636364 70 8.73729393454582e-10 4 2.08462043672938 2.28753468227071 1 16.5614450600701 4 105 204 60 812 7 15 70 121 96 53 16 M11939 GO_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHESION.html The attachment of a cell to the underlying substrate via adhesion molecules. 108/262 Gene Ontology BP GO:0031589 1.37786489588227e-13 6.66398615789726e-12 5 215 79 1.25260445080214e-14 2 1.92623571950194 2.07658981067831 1 25.5025866191706 2 237 89 132 1042 9 56 22 650 79 47 17 M16960 GO_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. 90/259 Gene Ontology BP GO:0048592 2.79867616875571e-11 9.56956380061175e-10 50 119.636363636364 83 2.54425106253755e-12 50 2.01336364519562 2.07999846000603 1 21.5111619884196 50 55 126 62 83 71 221 195 291 50 112 18 M13140 GO_CHEMOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of chemicals. 6/29 Gene Ontology BP GO:0007635 1.13012526637432e-06 4.79631774385374e-06 85 633.363636363636 86 1.13012584110714e-07 51 2.3748268651246 2.3748268651246 1 14.9639935552556 82 723 4018 311 1028 86 59 72 78 459 51 19 M11606 GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 237/649 Gene Ontology BP GO:0051962 1.71944777976967e-13 8.23030519739234e-12 25 168.545454545455 90 1.56313434524528e-14 21 1.8712174858893 2.04039556770941 1 24.5709382393748 107 217 90 26 291 24 181 21 816 48 33 20 M13631 GO_NEURON_PROJECTION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MORPHOGENESIS.html The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. 201/670 Gene Ontology BP GO:0048812 1.32192167893926e-13 6.46071826875262e-12 35 160.090909090909 93 1.20174698085395e-14 21 1.73353280632073 1.88494470114748 1 22.9789046431547 32 26 88 244 97 21 118 81 856 93 105 21 M16341 GO_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 42/169 Gene Ontology BP GO:0030814 8.23188796505734e-08 1.08928103117624e-06 15 595.090909090909 99 7.48353479370496e-09 11 1.74600500782572 1.87314725936819 1 12.3332673129104 94 99 430 760 80 11 58 1010 2828 1163 13 22 M11134 GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. 96/294 Gene Ontology BP GO:0051146 6.96003396359277e-13 2.96471905440011e-11 45 133.818181818182 100 6.32730360326813e-14 20 2.39707653401953 2.52763752510824 1 29.8955489697847 41 244 100 44 58 20 80 122 443 162 158 23 M13349 GO_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFIBRIL_ASSEMBLY.html Formation of myofibrils, the repeating units of striated muscle. 34/82 Gene Ontology BP GO:0030239 7.52652678339699e-11 2.29923457862557e-09 140 105.727272727273 100 6.84229707604953e-12 11 2.56920408484216 2.7389355308779 1 26.2912253907517 11 100 139 17 50 47 74 202 137 131 255 24 M13993 GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. 98/268 Gene Ontology BP GO:0048738 2.37669369718391e-13 1.11464533697221e-11 30 142.909090909091 100 2.16063063380379e-14 16 2.2613296390058 2.36825384655702 1 29.3406424502259 27 52 92 68 205 16 122 327 414 100 149 25 M11323 GO_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATRIX_ADHESION.html The binding of a cell to the extracellular matrix via adhesion molecules. 71/186 Gene Ontology BP GO:0007160 3.19375204052747e-11 1.06680508806972e-09 15 196.909090909091 103 2.90341094597622e-12 15 2.00110216238492 2.16963783328974 1 21.2682851902238 15 66 128 136 895 32 103 55 516 170 50 26 M14009 GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. 13/32 Gene Ontology BP GO:0072498 6.83575194688132e-08 9.61769584526363e-07 5 233.909090909091 104 6.21432014479917e-09 3 2.72205244787767 2.72205244787767 1 19.4021311943989 3 313 248 86 1343 8 18 185 76 189 104 27 M15451 GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 274/721 Gene Ontology BP GO:0010720 1.7223599578372e-15 1.19356974391614e-13 35 217 112 1.565781779852e-16 32 1.88577130730643 2.11957251031938 1 28.8692538288081 155 364 62 32 338 112 307 71 826 34 86 28 M12415 GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. 26/50 Gene Ontology BP GO:0048745 1.52508401210856e-07 1.53951377426715e-06 65 140.909090909091 114 1.38644010711859e-08 52 2.05424552809631 2.32707522995303 1 14.1449711085415 64 114 273 88 218 91 67 52 190 185 208 29 M13090 GO_CARDIAC_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_MORPHOGENESIS.html The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 47/124 Gene Ontology BP GO:0003208 1.15786369811619e-14 6.98176772773181e-13 90 150.363636363636 115 1.05260336192382e-15 42 2.46775107816974 2.66396065042761 1 35.5362305753039 89 88 72 42 115 186 296 299 161 109 197 30 M11013 GO_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of a tissue are generated and organized. 311/815 Gene Ontology BP GO:0048729 2.83490296637132e-25 1.19658677026019e-22 15 181.363636363636 116 2.57718451488301e-26 11 2.00871396967367 2.11391018010969 1 52.1647903722887 95 12 11 11 122 116 323 517 520 15 253 31 M14697 GO_CELLULAR_COMPONENT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MORPHOGENESIS.html The process in which cellular structures, including whole cells or cell parts, are generated and organized. 484/1351 Gene Ontology BP GO:0032989 2.22796537413168e-18 3.13467976730103e-16 5 183.454545454545 118 2.02542306739244e-19 4 1.76296071720834 1.88465120540679 1 32.3786742689003 135 4 32 5 118 34 394 199 928 40 129 32 M12096 GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 58/202 Gene Ontology BP GO:0030799 4.19128961429743e-08 6.65956588649098e-07 130 455.090909090909 127 3.81026335831546e-09 30 1.63565263635916 1.75876868802713 1 11.9678287715502 127 83 276 317 33 30 77 785 2743 499 36 33 M14533 GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 233/622 Gene Ontology BP GO:0010975 1.57899387189499e-14 9.3990622400108e-13 140 259.090909090909 131 1.43544897444999e-15 23 1.9015039175869 2.07913533593367 1 27.0912820607498 139 871 73 23 265 98 342 131 768 57 83 34 M13335 GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. 51/122 Gene Ontology BP GO:0031032 2.08317972749697e-09 5.14478908232364e-08 20 155.454545454545 132 1.89379975406322e-10 17 2.31810180046834 2.47791323296732 1 20.0150471818589 17 87 174 198 441 19 71 89 200 282 132 35 M11569 GO_SARCOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOMERE_ORGANIZATION.html The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. 26/61 Gene Ontology BP GO:0045214 5.3835545974846e-08 8.14196872837817e-07 20 155.272727272727 133 4.89414066293088e-09 16 2.77011296437949 2.98135507285577 1 19.9820856794947 16 118 241 133 142 56 89 246 103 336 228 36 M14876 GO_UROGENITAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UROGENITAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. 164/437 Gene Ontology BP GO:0001655 7.27748784191459e-22 1.7378921543808e-19 20 232.181818181818 133 6.61589803810415e-23 18 2.12392588599635 2.25519093149481 1 47.2008424345777 236 29 18 22 102 133 381 600 664 19 350 37 M15495 GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. 19/33 Gene Ontology BP GO:0033627 2.03099793739834e-07 1.82750453940707e-06 5 235.363636363636 135 1.84636193172383e-08 4 2.43391071765496 2.43391071765496 1 16.5445118176261 8 135 299 337 1002 5 4 48 391 311 49 38 M12192 GO_DETECTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS.html The series of events by which a mechanical stimulus is received and converted into a molecular signal. 29/82 Gene Ontology BP GO:0050982 1.14937938226447e-07 1.31726257509087e-06 10 242 142 1.04489040210295e-08 2 2.01619684815819 2.13820631624996 1 14.0447012764532 6 279 285 332 992 2 19 67 511 142 27 39 M12279 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE.html Any process that modulates the size of an anatomical structure. 270/671 Gene Ontology BP GO:0090066 3.77253498326969e-15 2.46702534187622e-13 100 281.363636363636 144 3.4295772575179e-16 63 1.83399016873671 1.93477040410391 1 27.3914673705791 101 213 66 144 254 63 189 529 1340 99 97 40 M11475 GO_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 277/850 Gene Ontology BP GO:0031175 9.47545828227247e-13 3.89332325704346e-11 150 244.272727272727 149 8.61405298388778e-14 16 1.7251571100489 1.88150768896627 1 21.2737513872071 149 16 104 350 242 65 375 167 968 124 127 41 M15608 GO_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_GUIDANCE.html The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. 96/347 Gene Ontology BP GO:0097485 4.40175234643036e-11 1.43924902425888e-09 20 168.454545454545 150 4.00159304228949e-12 20 1.9944176463371 2.17437552381455 1 20.8899792277496 20 243 131 247 159 74 150 33 421 260 115 42 M15954 GO_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 704/2148 Gene Ontology BP GO:0048468 4.92355643394919e-13 2.11667338174316e-11 155 652.636363636364 151 4.92355643395028e-14 8 1.83155177868301 1.98291306831887 1 23.1599998975127 151 190 4487 8 119 66 546 211 1242 16 143 43 M10631 GO_CARDIAC_CHAMBER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_MORPHOGENESIS.html The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. 74/183 Gene Ontology BP GO:0003206 6.11536198525042e-14 3.22654837471792e-12 115 252.181818181818 152 5.55941998659145e-15 64 2.16498651161082 2.35561568347318 1 29.471415248763 113 64 82 152 103 257 688 429 513 113 260 44 M10365 GO_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_TISSUE_DEVELOPMENT.html The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. 155/442 Gene Ontology BP GO:0060537 8.12263179305605e-15 5.03690371558066e-13 35 189.272727272727 154 7.38421072096006e-16 29 2.1470615109596 2.31279013047703 1 31.2788858045473 34 378 69 214 143 29 154 233 585 82 161 45 M14608 GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. 28/84 Gene Ontology BP GO:0007157 2.80473099372467e-08 4.89562631724197e-07 75 165.363636363636 155 2.54975548134687e-09 35 2.07226968933203 2.40429957689572 1 15.4905516799683 74 112 224 288 204 82 35 130 344 171 155 46 M10039 GO_CARDIAC_CHAMBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_DEVELOPMENT.html The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. 99/257 Gene Ontology BP GO:0003205 6.25946751473131e-12 2.27052403678887e-10 70 224.818181818182 156 5.69042501340828e-13 31 2.01076720352319 2.1197217353974 1 22.9716074286525 67 50 119 156 31 187 467 373 669 132 222 47 M11450 GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 390/1070 Gene Ontology BP GO:0051960 2.94082443757127e-18 3.95250640493276e-16 130 245.545454545455 156 2.67347676142842e-19 24 1.7760799860071 1.97783933820945 1 32.4077968302704 156 206 33 24 320 126 378 129 1109 29 191 48 M16634 GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 152/389 Gene Ontology BP GO:0010976 1.56559931665896e-10 4.57174693537583e-09 90 256.909090909091 157 1.42327210615489e-11 26 1.99453047403517 2.13488996676547 1 19.7051847877077 86 1064 147 201 261 39 212 157 535 98 26 49 M15330 GO_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron. 417/1295 Gene Ontology BP GO:0030182 3.78683932982514e-18 4.75197162388598e-16 215 258.363636363636 158 3.44258120893195e-19 9 1.7968602416781 1.9294722505582 1 32.6166802350536 211 9 36 21 158 153 675 227 1076 84 192 50 M15276 GO_SENSORY_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_MORPHOGENESIS.html Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 133/407 Gene Ontology BP GO:0090596 2.56784757644812e-15 1.70321661392123e-13 160 311.363636363636 159 2.3344068876801e-16 37 1.9167100804692 1.97969665341999 1 28.9922693671382 159 37 65 54 48 398 611 800 781 43 429 51 M12739 GO_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of neuron differentiation. 298/801 Gene Ontology BP GO:0045664 1.07326823873722e-16 9.77094986756258e-15 165 229.909090909091 162 9.75698398852015e-18 20 1.83330931037921 2.04425722123327 1 30.4266344274529 162 211 48 20 163 131 468 244 910 46 126 52 M16122 GO_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. 70/195 Gene Ontology BP GO:0055001 1.0488228487424e-09 2.75123417328304e-08 40 168.454545454545 164 9.53475317493105e-11 37 2.39055016906198 2.5462804898033 1 21.4104041237608 37 72 164 148 198 41 85 231 394 194 289 53 M15398 GO_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_GROWTH.html The increase in size or mass of the heart. 20/43 Gene Ontology BP GO:0060419 1.27830925421962e-07 1.40269020941895e-06 80 234.181818181818 166 1.16209938954159e-08 9 2.04008554201119 2.11487916964375 1 14.1451575545181 76 450 701 209 166 12 9 49 266 619 19 54 M13376 GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of cardiac muscle tissue are generated and organized. 43/112 Gene Ontology BP GO:0055008 4.8517990993858e-13 2.1053180577989e-11 120 315.272727272727 168 4.41072645398805e-14 56 2.73449629892003 2.98972695905608 1 34.5853153287905 119 94 99 56 539 387 490 781 152 168 583 55 M10531 GO_CIRCULATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. 197/596 Gene Ontology BP GO:0003013 5.83198350921596e-21 1.11690274045895e-18 25 287.545454545455 170 5.30180319019633e-22 22 2.11240013448175 2.33455729330633 1 44.9227919629275 22 224 23 147 584 59 170 514 1086 65 269 56 M14070 GO_REGULATION_OF_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GASTRULATION.html Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. 31/69 Gene Ontology BP GO:0010470 1.51391495994156e-09 3.82016693424385e-08 10 216.363636363636 170 1.37628632816668e-10 1 2.026473542959 2.1517357141048 1 17.8074202053739 7 276 170 353 729 1 52 58 544 174 16 57 M12556 GO_MESENCHYMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. 69/195 Gene Ontology BP GO:0048762 9.59984583719466e-14 4.79269722818224e-12 175 260.909090909091 171 8.72713257926823e-15 40 2.06517282476953 2.31836138997663 1 27.6922760091547 171 70 87 40 145 319 425 404 848 221 140 58 M15968 GO_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. 64/190 Gene Ontology BP GO:0048593 6.41767020179751e-08 9.22515255323401e-07 75 191.272727272727 172 5.83424580818985e-09 56 1.91176745059164 2.00101022756856 1 13.6676008993493 202 75 365 73 56 143 172 440 292 209 77 59 M15881 GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 56/141 Gene Ontology BP GO:0007229 9.69920756382997e-08 1.20410215825836e-06 115 231.909090909091 173 8.81746181040175e-09 79 2.25947690708058 2.32607485081804 1 15.843787318233 111 84 339 79 114 236 502 123 351 439 173 60 M12440 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD.html The morphogenetic process in which an epithelial sheet bends along a linear axis. 11/25 Gene Ontology BP GO:0060571 2.46411461567703e-08 4.45170589906166e-07 15 431.727272727273 174 2.24010422116036e-09 11 2.35909379503618 2.69604391752007 1 17.7499756517835 260 598 845 231 14 170 63 11 150 2233 174 61 M10101 GO_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 336/1049 Gene Ontology BP GO:0048666 2.46746986151489e-15 1.66035689377009e-13 200 282.181818181818 176 2.243154419559e-16 10 1.74679975452836 1.87397016319149 1 26.4450994331288 199 10 64 142 176 130 624 335 1149 69 206 62 M10733 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. 21/59 Gene Ontology BP GO:0050974 1.96965797426494e-07 1.78267484883277e-06 15 280.909090909091 178 1.79059831873477e-08 4 2.33822574622579 2.44597825443776 1 15.9239700907869 12 290 269 178 1555 4 43 107 328 275 29 63 M12450 GO_CELL_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. 131/292 Gene Ontology BP GO:0034330 2.21617683171155e-18 3.13467976730103e-16 265 214.363636363636 180 2.01470621064686e-19 2 2.19554778090557 2.28096985609914 1 40.3236024905959 261 36 31 2 153 180 465 544 384 67 235 64 M14884 GO_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ASSEMBLY.html A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. 102/211 Gene Ontology BP GO:0034329 2.90211242178334e-17 3.06238817598638e-15 45 222.181818181818 184 2.63828401980304e-18 4 2.30077341263369 2.45028254168831 1 39.5582662809415 218 42 42 4 300 129 427 554 440 104 184 65 M16767 GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM.html A circulatory process that occurs at the level of the vasculature. 84/233 Gene Ontology BP GO:0003018 1.32551651710752e-10 3.89517290438621e-09 40 317.272727272727 184 1.2050150156249e-11 40 2.01701188845827 2.08746266279527 1 20.0934873240223 40 247 146 357 274 43 99 687 1304 184 109 66 M15892 GO_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. 73/178 Gene Ontology BP GO:0007498 1.32054802410434e-07 1.42588476184103e-06 85 518.272727272727 186 1.20049827579102e-08 67 1.80449548414888 1.88367467837993 1 12.4964421105266 85 647 825 891 177 67 139 186 1235 1285 164 67 M16921 GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 204/508 Gene Ontology BP GO:0031346 5.13438042708446e-09 1.1406185800456e-07 190 307.181818181818 187 4.66761858097011e-10 61 1.83003213947716 2.01736737419977 1 15.0513394514771 237 872 190 61 91 144 330 116 1059 187 92 68 M11506 GO_TOOTH_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOOTH_MINERALIZATION.html The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. 13/32 Gene Ontology BP GO:0034505 3.83931999258892e-07 2.57804519639595e-06 310 229.545454545455 188 3.49029151146025e-08 19 2.15564808653914 2.25973604379879 1 14.2714285317378 19 151 314 308 516 77 188 374 147 121 310 69 M12926 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 26/63 Gene Ontology BP GO:2001240 5.60774419413128e-06 1.5360918167169e-05 540 514.636363636364 190 5.09796226198181e-07 45 2.11302739874887 2.16144403529057 1 12.049017032957 98 1401 539 190 1928 83 45 155 536 576 110 70 M16493 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. 26/63 Gene Ontology BP GO:1901099 5.17829695002568e-06 1.4428358505804e-05 540 515.090909090909 191 4.70755376235709e-07 46 2.11302739874887 2.16144403529057 1 12.1171027690253 99 1402 540 191 1929 84 46 150 537 577 111 71 M16562 GO_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. 767/2129 Gene Ontology BP GO:0009888 1.46950575751065e-24 5.2483963324015e-22 535 702 193 1.46950575751065e-25 2 1.913659880728 2.0060336665661 1 48.240735309932 157 189 4581 193 75 119 532 534 1052 2 288 72 M14474 GO_DETECTION_OF_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_ABIOTIC_STIMULUS.html The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. 70/227 Gene Ontology BP GO:0009582 1.15380265591205e-10 3.43404213551258e-09 125 260.454545454545 194 1.04891150542959e-11 66 1.94081255831113 2.02894859307347 1 19.4601994106549 125 71 144 358 328 89 194 452 805 66 233 73 M12572 GO_MUSCLE_STRUCTURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_STRUCTURE_DEVELOPMENT.html The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. 239/653 Gene Ontology BP GO:0061061 2.49395226266938e-21 5.51400969313045e-19 200 227.090909090909 196 2.26722932969943e-22 20 2.05843914323332 2.24569423100969 1 44.5227504262922 35 216 20 196 241 42 261 247 988 56 196 74 M14065 GO_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 140/418 Gene Ontology BP GO:0008544 5.01412733280839e-18 5.82014830155734e-16 35 212.909090909091 196 4.55829757528035e-19 9 2.32898111191961 2.63925780073038 1 42.0328065698223 273 35 39 9 87 479 733 196 219 32 240 75 M10110 GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS.html The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 507/1359 Gene Ontology BP GO:0048646 2.48083276219464e-08 4.46453740886423e-07 160 675.181818181818 198 2.48083278989003e-09 59 1.81309924911137 1.92778527406747 1 13.6391918823923 160 198 3534 137 77 179 498 772 1423 59 390 76 M16957 GO_DETECTION_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CALCIUM_ION.html The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. 6/20 Gene Ontology BP GO:0005513 5.61417300542654e-09 1.22955685208469e-07 30 629.545454545455 199 5.61417301961007e-10 1 2.71582799521927 2.71582799521927 1 22.2317769379358 46 484 4640 199 266 27 1 465 6 761 30 77 M15430 GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION.html The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. 183/616 Gene Ontology BP GO:0048667 2.05263653991044e-10 5.91949779801502e-09 120 284.272727272727 201 1.86603321827451e-11 114 1.75436780899188 1.93134273136463 1 17.099285190542 120 512 149 154 201 138 395 114 829 241 274 78 M10670 GO_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_PRIMARY_GERM_LAYER.html The formation of the ectoderm, mesoderm and endoderm during gastrulation. 77/178 Gene Ontology BP GO:0001704 4.70688504002445e-08 7.21256344581964e-07 40 286.272727272727 210 4.27898649157084e-09 39 2.00980279035506 2.07170301072317 1 14.6229491514155 39 63 239 87 552 107 147 313 942 450 210 79 M13648 GO_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 296/777 Gene Ontology BP GO:0007507 1.67777533133312e-14 9.8606466625059e-13 215 312.454545454545 212 1.52525030121193e-15 62 1.8879418738785 2.09936836576054 1 26.851494003167 62 212 74 69 256 212 418 434 1214 92 394 80 M14856 GO_MYELIN_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_ASSEMBLY.html The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. 9/30 Gene Ontology BP GO:0032288 1.27182954925419e-08 2.50216296490983e-07 390 696.363636363636 213 1.27182955653316e-09 3 2.83993082596103 2.83993082596103 1 22.2095924746978 387 941 4306 165 3 325 213 34 63 1209 14 81 M14930 GO_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_SYSTEM_PROCESS.html A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. 161/419 Gene Ontology BP GO:0003012 1.88133266332344e-16 1.61759769552051e-14 145 348 216 1.71030242120312e-17 31 2.0734308269646 2.38425719484198 1 33.8740767513575 144 31 50 197 305 216 469 887 921 123 485 82 M16360 GO_CELLULAR_GLUCURONIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCURONIDATION.html The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. 3/23 Gene Ontology BP GO:0052695 3.36497179339577e-08 5.74395736644726e-07 220 746.272727272727 216 3.36497184434943e-09 1 3.55389468427202 3.55389468427202 1 26.2737529911114 216 862 4552 134 93 423 372 10 1 1424 122 83 M16294 GO_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXONOGENESIS.html Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. 97/250 Gene Ontology BP GO:0050770 1.96828160190077e-08 3.73009448066337e-07 105 328.909090909091 217 1.78934692682769e-09 95 1.9008916898772 2.06900945917173 1 14.4753882160663 105 1150 217 298 169 136 426 113 635 274 95 84 M15728 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. 11/23 Gene Ontology BP GO:0016338 5.62339369018172e-08 8.3684028536903e-07 55 303.545454545455 218 5.11217621265512e-09 54 2.38686681802452 -2.62139603407537 -1 17.1838718381711 54 156 243 465 1202 111 165 218 116 314 295 85 M10820 GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 208/544 Gene Ontology BP GO:0010769 2.62896807417735e-12 1.01719156403379e-10 220 272.090909090909 220 2.38997097652772e-13 45 1.77091155859192 1.94307345020792 1 20.9629946252027 175 220 111 45 388 217 401 290 751 71 324 86 M15304 GO_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 96/277 Gene Ontology BP GO:0048863 5.39407593909044e-17 5.21764470524936e-15 155 346.272727272727 221 4.90370539917313e-18 45 2.00469943748084 2.21083181008757 1 33.9181656363363 154 48 45 518 648 221 312 352 1203 163 145 87 M14932 GO_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_DEVELOPMENT.html The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. 97/268 Gene Ontology BP GO:0060485 4.43066774784453e-16 3.48671022936308e-14 95 267.181818181818 222 4.02787977076774e-17 55 2.11272777308313 2.36280230559142 1 33.6812906687489 92 242 55 145 301 222 285 375 923 120 179 88 M12873 GO_CEREBRAL_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_DEVELOPMENT.html The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. 65/190 Gene Ontology BP GO:0021987 7.83350201016792e-07 3.73418376110982e-06 165 382 223 7.12136799948259e-08 21 1.93602218922158 2.03360513877584 1 12.4483719243935 164 532 404 182 1033 141 223 64 876 562 21 89 M13151 GO_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MORPHOGENESIS.html Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 425/1215 Gene Ontology BP GO:0009887 1.82537714068836e-37 4.23761303210803e-34 5 365.909090909091 223 1.65943376426215e-38 2 2.00948672282383 2.17444386625927 1 79.4432318532907 223 6 2 125 96 577 831 727 794 3 641 90 M14026 GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT.html The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. 642/1793 Gene Ontology BP GO:0006928 3.62211788546542e-13 1.61706666752076e-11 150 670.818181818182 224 3.62211788546601e-14 14 1.85602369715125 1.96778402156683 1 23.7265301462643 150 191 4173 127 224 147 337 378 1381 14 257 91 M14896 GO_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_DEVELOPMENT.html The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. 191/528 Gene Ontology BP GO:0001654 2.53887252408429e-13 1.16712724052706e-11 220 342.181818181818 227 2.30806593098599e-14 27 1.91190054371715 2.04118410534811 1 24.7615611003961 217 27 94 164 227 382 524 666 806 149 508 92 M11955 GO_REPLACEMENT_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLACEMENT_OSSIFICATION.html Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. 18/52 Gene Ontology BP GO:0036075 3.55370022108821e-08 5.94005221467394e-07 135 359 228 3.2306366168107e-09 132 2.35897211970303 2.50634475790102 1 17.3990130590385 188 132 228 174 1616 243 280 220 392 135 341 93 M15454 GO_ENDOCHONDRAL_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_OSSIFICATION.html Replacement ossification wherein bone tissue replaces cartilage. 18/52 Gene Ontology BP GO:0001958 3.55370022108821e-08 5.94005221467394e-07 230 360.454545454545 229 3.2306366168107e-09 133 2.35897211970303 2.50634475790102 1 17.3990130590385 189 133 229 175 1617 244 281 226 393 136 342 94 M14538 GO_CARDIOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. 58/192 Gene Ontology BP GO:0035051 2.54115850857189e-08 4.55544361208467e-07 535 282.181818181818 231 2.31014412538555e-09 97 2.49409602614318 2.57557295593909 1 18.7361834098025 147 535 219 98 231 97 168 468 533 338 270 95 M12997 GO_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_MORPHOGENESIS.html The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 149/374 Gene Ontology BP GO:0003007 9.26298002305029e-14 4.67478437467636e-12 90 280.090909090909 232 8.42089093004604e-15 82 2.06152237960471 2.29224166228904 1 27.6697463310252 100 232 86 82 458 215 271 342 839 86 370 96 M12628 GO_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CONTRACTION.html A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. 128/347 Gene Ontology BP GO:0006936 4.92078151950559e-14 2.71990340417434e-12 210 362.818181818182 235 4.47343774500518e-15 78 2.12714383075513 2.50193213733612 1 29.1432067834691 209 235 78 139 276 219 433 977 736 167 522 97 M13073 GO_ENDODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. 31/73 Gene Ontology BP GO:0035987 4.39865502492497e-08 6.92303568838191e-07 65 329.181818181818 235 3.99877737533745e-09 55 2.2071673000371 2.28470954972583 1 16.1054592144208 61 108 235 260 1155 75 55 252 844 383 193 98 M14014 GO_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYSTEM_PROCESS.html A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. 606/2821 Gene Ontology BP GO:0003008 5.25941746261785e-17 5.1956330380712e-15 170 680.818181818182 237 5.25941746261787e-18 5 1.96009619945626 2.11733872080307 1 33.1677720246344 166 192 4170 126 273 81 529 492 1218 5 237 99 M12538 GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. 35/94 Gene Ontology BP GO:0003229 1.31535708154738e-10 3.88993817173533e-09 235 337.181818181818 238 1.19577916511457e-11 102 2.58145655287442 2.77135311571977 1 25.7182757314916 235 102 145 157 452 426 883 494 163 238 414 100 M14229 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. 4/32 Gene Ontology BP GO:1902547 1.98743074525238e-08 3.75107355699463e-07 10 866 238 1.98743076302684e-09 8 2.15960325051275 2.15960325051275 1 16.4392589332827 238 619 4209 314 1868 174 199 8 9 1708 180 101 M16349 GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 461/1347 Gene Ontology BP GO:0007417 9.38755393982829e-13 3.89164401273417e-11 455 418.818181818182 238 8.5341399453021e-14 103 1.87167702856756 2.08065146868953 1 23.0809753213824 452 869 103 213 238 151 630 491 1161 165 134 102 M10383 GO_EPIDERMIS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_MORPHOGENESIS.html The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 27/52 Gene Ontology BP GO:0048730 1.1616940003059e-06 4.90532505507653e-06 350 385.545454545455 240 1.0560860124822e-07 76 2.8616969556581 3.32564855049269 1 17.9987192550487 350 1172 329 212 1000 134 76 240 136 478 114 103 M15872 GO_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 66/188 Gene Ontology BP GO:0072006 3.58147109518853e-18 4.6191028597112e-16 60 251.636363636364 245 3.25588281380774e-19 15 2.2619336190908 2.56329092544274 1 41.0917131353527 60 68 35 15 528 245 494 511 283 53 476 104 M11392 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE.html A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. 14/27 Gene Ontology BP GO:0035584 2.93025309172731e-06 9.31860623622595e-06 35 566.272727272727 249 2.66386999512367e-07 33 2.34618385082093 2.34618385082093 1 13.9818330010438 33 1418 536 744 2214 58 151 110 249 654 62 105 M15958 GO_TELENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. 135/430 Gene Ontology BP GO:0021537 7.23696629599329e-08 9.94119364269137e-07 250 382.909090909091 250 6.57906048550498e-09 24 2.01046288541927 2.13641563092648 1 14.2958744902521 247 635 250 180 1131 95 385 24 855 369 41 106 M10841 GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 247/769 Gene Ontology BP GO:0071407 1.04584777719197e-09 2.75123417328304e-08 165 466.454545454545 251 9.50770706990138e-11 81 1.91302509002879 2.00154526038539 1 17.1335619738998 357 1229 163 101 464 165 618 251 1455 247 81 107 M15221 GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of embryonic development. 68/180 Gene Ontology BP GO:0045995 1.62817455981873e-09 4.06430886088084e-08 100 265.818181818182 253 1.48015869183974e-10 27 2.12663996914543 2.29860982500591 1 18.6198431372999 96 400 172 303 717 53 260 27 583 253 60 108 M14813 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. 560/1430 Gene Ontology BP GO:0022603 8.23302419955775e-09 1.72188879993453e-07 245 727.181818181818 258 8.23302423005996e-10 55 1.77906710907771 1.95450173151304 1 14.2552110823104 245 195 4297 141 258 268 605 182 1426 55 327 109 M12483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. 16/34 Gene Ontology BP GO:0014912 9.36106096521457e-08 1.18752475577845e-06 165 497.545454545455 259 8.51005578502755e-09 15 2.06904134935979 2.29934154344901 1 14.5231815695771 161 1982 895 259 947 52 26 15 284 807 45 110 M13089 GO_RENAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_TUBULE_DEVELOPMENT.html The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. 46/137 Gene Ontology BP GO:0061326 3.17872301638551e-12 1.19990333049414e-10 270 311.181818181818 266 2.88974819671827e-13 38 2.0595351390808 2.32546226369196 1 24.2045116472895 266 86 114 38 323 523 1159 266 156 73 419 111 M13393 GO_MUSCLE_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_MORPHOGENESIS.html The process in which the anatomical structures of muscle are generated and organized. 51/133 Gene Ontology BP GO:0048644 5.79578343505958e-14 3.09308304471053e-12 80 295 267 5.26889403187246e-15 79 2.60246977751228 2.80591632725785 1 35.4833262310269 79 262 81 151 497 267 537 615 279 114 363 112 M15223 GO_SENSORY_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. 257/760 Gene Ontology BP GO:0007423 3.52394269495694e-17 3.6359257628189e-15 270 387.090909090909 267 3.20358426814266e-18 20 1.86604805512271 2.00196065814273 1 31.9190236433695 267 20 43 58 86 478 709 890 1073 101 533 113 M12444 GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 325/835 Gene Ontology BP GO:0031344 7.94696220430273e-11 2.41161735389396e-09 140 347.454545454545 268 7.22451109508165e-12 13 1.73141786348222 1.90557539399262 1 17.675467212755 351 13 141 204 140 288 622 392 1265 138 268 114 M16262 GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of cation channel activity. 48/127 Gene Ontology BP GO:2001257 9.21307228406026e-08 1.17841031996947e-06 235 524.090909090909 268 8.3755206089833e-09 101 1.74115120277207 1.94180049782582 1 12.2285301261066 234 268 888 1079 101 137 193 377 1471 814 203 115 M12378 GO_PALATE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALATE_DEVELOPMENT.html The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. 67/155 Gene Ontology BP GO:0060021 1.31086242853887e-07 1.42077719221115e-06 160 388.272727272727 271 1.19169318786015e-08 74 1.81525465301701 2.00604274438698 1 12.5743024840547 97 74 262 279 1167 158 396 271 1108 300 159 116 M16228 GO_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 461/1233 Gene Ontology BP GO:0060284 2.08690508435112e-17 2.36329275771763e-15 275 344.090909090909 274 1.8971864403192e-18 40 1.78165661858512 1.97530273039057 1 30.870380228386 274 201 40 140 340 383 539 253 1164 52 399 117 M11417 GO_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELINATION.html Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 25/53 Gene Ontology BP GO:0031641 1.04202274530398e-07 1.26675905597665e-06 360 420.818181818182 275 9.47293449690047e-09 32 2.40400163868945 3.01880579076323 1 16.7944768211153 360 679 792 92 123 275 371 228 73 1604 32 118 M16151 GO_AORTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_MORPHOGENESIS.html The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. 25/54 Gene Ontology BP GO:0035909 4.0681562501696e-06 1.19471533646663e-05 180 450.636363636364 275 3.69833070260795e-07 116 2.33119002003786 2.36756096717033 1 13.5944684194337 116 1175 360 179 1488 240 383 176 256 309 275 119 M16378 GO_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 153/370 Gene Ontology BP GO:0009612 1.10420326529527e-09 2.86414288310947e-08 505 362.454545454545 276 1.00382115077226e-10 166 1.89029718474164 2.13066077745555 1 16.8908910247498 177 229 166 267 504 315 501 255 1005 292 276 120 M10785 GO_LOOP_OF_HENLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOOP_OF_HENLE_DEVELOPMENT.html The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. 8/16 Gene Ontology BP GO:0072070 9.10735007532714e-08 1.16810570165038e-06 1525 1320.90909090909 277 9.10735044857438e-09 18 2.13448023509002 2.64287293511445 1 15.0006212154283 1521 170 3633 149 219 3797 4279 18 46 421 277 121 M12296 GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. 8/21 Gene Ontology BP GO:0048714 3.90583252158689e-06 1.15508155399541e-05 200 822.545454545455 277 3.90583938659133e-07 58 4.50570101208555 4.50570101208555 1 26.3534600576684 198 610 3886 105 1508 305 277 144 58 1739 218 122 M16857 GO_REGULATION_OF_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. 325/834 Gene Ontology BP GO:0022604 3.3404264233404e-12 1.25077418415883e-10 315 344.090909090909 279 3.03675129395043e-13 39 1.80544792628484 1.99096687764998 1 21.1798054697184 312 208 115 39 257 407 667 279 964 83 454 123 M10505 GO_COLLAGEN_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_FIBRIL_ORGANIZATION.html Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. 27/60 Gene Ontology BP GO:0030199 2.8038851947039e-08 4.89562631724197e-07 5 392.090909090909 281 2.54898657312657e-09 5 2.33876049991426 2.33876049991426 1 17.4826138825758 5 281 223 527 1896 99 49 326 402 207 298 124 M13430 GO_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_MIGRATION.html Any process that modulates the frequency, rate or extent of neuron migration. 27/79 Gene Ontology BP GO:2001222 8.13181216237345e-07 3.81373776463635e-06 55 405.454545454545 281 7.39255924374459e-08 55 2.35173059207782 2.53976844443074 1 15.0958181567018 55 431 305 91 1927 220 214 281 348 364 224 125 M14257 GO_HEAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_DEVELOPMENT.html The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. 399/1144 Gene Ontology BP GO:0060322 1.61587970238351e-11 5.72712172379133e-10 505 420.636363636364 281 1.46898154763216e-12 122 1.82278420212954 2.02913331848575 1 19.9564033531172 505 502 122 216 281 200 854 298 1252 228 169 126 M14962 GO_ENDODERM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_FORMATION.html The formation of the endoderm during gastrulation. 37/84 Gene Ontology BP GO:0001706 7.91169143521816e-08 1.06475314010777e-06 120 505.454545454545 281 7.19244701794568e-09 98 2.16310757302315 2.28470954972583 1 15.3049031785774 117 98 252 266 1548 281 128 608 1312 444 506 127 M16461 GO_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIOR.html The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 235/825 Gene Ontology BP GO:0007610 2.07330545872141e-12 8.29858383176165e-11 225 322 281 1.88482314429397e-13 85 1.89905020010342 2.12983434076683 1 22.6786896388067 224 218 107 409 298 156 304 308 1152 85 281 128 M10308 GO_BODY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_MORPHOGENESIS.html The process in which the anatomical structures of the soma are generated and organized. 34/79 Gene Ontology BP GO:0010171 6.13748218006917e-07 3.23212152206309e-06 90 423.909090909091 282 5.57953081116628e-08 88 1.69300396685116 1.87904034317097 1 11.0115608063613 88 104 718 659 748 115 157 205 861 726 282 129 M13053 GO_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DIFFERENTIATION.html The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. 37/95 Gene Ontology BP GO:0002062 2.93398232907689e-07 2.20765613742814e-06 285 485.909090909091 284 2.66725701851015e-08 51 2.10937566756371 2.1887701730485 1 14.1333999178843 68 665 284 598 1861 51 96 328 881 283 230 130 M14928 GO_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. 43/111 Gene Ontology BP GO:0030510 8.55300690085581e-08 1.11549469215375e-06 130 500.454545454545 285 7.77546112124882e-09 90 1.75659934989582 1.8022947957667 1 12.3866120330442 130 787 1008 546 90 285 267 152 1469 520 251 131 M15499 GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS.html The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. 14/31 Gene Ontology BP GO:0035313 3.84733662276469e-08 6.23261737178407e-07 220 402.272727272727 286 3.49757880913318e-09 150 2.60562684832483 2.47643612406294 1 19.1538081786672 220 150 232 329 959 206 286 960 289 220 574 132 M12201 GO_TAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAXIS.html The directed movement of a motile cell or organism in response to an external stimulus. 219/733 Gene Ontology BP GO:0042330 1.3978891095421e-15 9.83393808424846e-14 140 440.272727272727 287 1.27080828140191e-16 61 1.93616807663326 2.09428134860726 1 29.833717441873 137 745 61 851 287 256 412 269 1331 195 299 133 M10682 GO_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CYCLE.html The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. 47/143 Gene Ontology BP GO:0042633 4.6575967840557e-09 1.04489494798054e-07 370 320.454545454545 289 4.23417890356023e-10 187 2.55202224270642 2.74222649563801 1 21.1045279169548 366 542 187 289 521 296 233 237 204 271 379 134 M13884 GO_MOLTING_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLTING_CYCLE.html The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. 47/143 Gene Ontology BP GO:0042303 4.6575967840557e-09 1.04489494798054e-07 370 321.909090909091 290 4.23417890356023e-10 188 2.55202224270642 2.74222649563801 1 21.1045279169548 367 543 188 290 522 297 234 243 205 272 380 135 M11108 GO_NEGATIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LOCOMOTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. 165/444 Gene Ontology BP GO:0040013 3.61730350229549e-16 2.94651581774701e-14 55 402.909090909091 292 3.28845772935953e-17 53 1.83709828370741 1.94656139074588 1 29.4462809650575 53 375 53 292 756 168 263 498 1492 186 296 136 M10152 GO_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of neurological system. 333/2079 Gene Ontology BP GO:0050877 2.97949007479316e-18 3.95250640493276e-16 210 379.727272727273 293 2.70862734072106e-19 34 1.89599446184465 2.03434175583389 1 34.5958537884216 293 207 34 466 251 208 754 395 1207 47 315 137 M10512 GO_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 74/204 Gene Ontology BP GO:0051216 1.2033826667174e-07 1.35944178140362e-06 105 443.363636363636 293 1.09398430231044e-08 35 1.95233659613132 2.03894206741677 1 13.5681968740388 103 888 258 387 1322 35 308 93 1118 293 72 138 M15217 GO_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. 194/509 Gene Ontology BP GO:0035239 2.95155913306042e-12 1.13256934337186e-10 205 386.545454545455 293 2.68323557551308e-13 87 1.86293427132842 1.96488195383567 1 21.9493278733572 203 225 112 161 293 483 523 775 747 87 643 139 M13531 GO_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SIZE.html Any process that modulates the size of a cell. 113/258 Gene Ontology BP GO:0008361 3.72455465635889e-08 6.08912227798392e-07 230 457.727272727273 296 3.38595883583167e-09 31 1.80816912448587 1.90069982227334 1 13.3134111725843 230 962 231 482 615 44 253 296 1572 319 31 140 M16534 GO_BIOLOGICAL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOLOGICAL_ADHESION.html The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. 492/1424 Gene Ontology BP GO:0022610 7.37472029836257e-48 3.42408263452974e-44 5 463 296 6.70429118032967e-49 1 1.94212718701768 2.06919534785908 1 100 214 197 1 124 296 645 921 923 1016 1 755 141 M16556 GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/22 Gene Ontology BP GO:0051957 1.09020459586762e-07 1.29465148368895e-06 130 427 297 9.91095136265853e-09 20 2.89675832538471 2.89675832538471 1 20.2044417186882 129 595 727 414 1449 246 65 20 89 666 297 142 M14182 GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in an epithelial cell. 26/55 Gene Ontology BP GO:1904019 1.84088515592517e-06 6.69803448568157e-06 415 359.727272727273 299 1.67353336028822e-07 87 2.14952987210224 2.19107505001526 1 13.1750530429201 412 119 341 95 1183 451 458 267 299 245 87 143 M15345 GO_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. 19/91 Gene Ontology BP GO:0048663 8.77748572162486e-08 1.141564879706e-06 295 439.272727272727 302 7.97953279256914e-09 63 2.36614325226747 2.48547591744324 1 16.6566721921582 294 302 501 320 94 745 1478 66 218 751 63 144 M15227 GO_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MORPHOGENESIS.html The process in which bones are generated and organized. 47/125 Gene Ontology BP GO:0060349 7.99759783112832e-07 3.78906599284988e-06 305 508 305 7.27054612588541e-08 161 1.91044426970634 2.0997579612581 1 12.2695688088939 305 779 303 692 1376 299 668 161 629 176 200 145 M13139 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET.html The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. 42/92 Gene Ontology BP GO:0002011 2.61036907516909e-08 4.62593267786645e-07 530 695 306 2.37306282376541e-09 76 2.04921628123142 2.06340284920115 1 15.3779628492993 529 91 221 76 306 1250 2127 2061 303 193 488 146 M10470 GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. 25/70 Gene Ontology BP GO:0060688 5.35251391264492e-07 3.01598569131194e-06 285 404.818181818182 307 4.86592292262822e-08 15 2.28749576676857 2.3154775130238 1 14.9596808991178 282 676 334 64 693 124 97 1524 337 307 15 147 M15118 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. 42/84 Gene Ontology BP GO:0045669 2.76270345153919e-08 4.85880004753654e-07 215 299.727272727273 307 2.51154862384774e-09 15 2.13958693680519 2.21653926455343 1 16.0020705853494 215 414 401 307 15 470 229 408 239 315 284 148 M10455 GO_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. 152/408 Gene Ontology BP GO:0007517 6.6250582613476e-14 3.41779394527076e-12 155 395 308 6.02278023758888e-15 84 2.12240007717792 2.42279859940385 1 28.8288216779399 153 517 84 294 567 308 735 261 837 183 406 149 M10722 GO_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that modulates the frequency, rate or extent of developmental growth. 164/478 Gene Ontology BP GO:0048638 9.35277013492535e-09 1.92145627152471e-07 430 441.545454545455 308 8.502518340624e-10 85 1.94849927196892 2.17195923595135 1 15.5028977572103 426 1063 203 85 308 334 875 259 810 229 265 150 M12951 GO_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. 25/52 Gene Ontology BP GO:0045445 3.17392266196182e-07 2.31342589002963e-06 315 307.727272727273 308 2.88538465441931e-08 120 2.01710944436768 2.10219692085678 1 13.4666260046523 313 120 448 256 454 204 218 519 375 308 170 151 M15575 GO_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. 28/74 Gene Ontology BP GO:0060350 1.3434187568764e-06 5.44314265028097e-06 230 478.454545454545 309 1.22129052475355e-07 172 2.07481674217355 2.22137833620637 1 12.9385636975613 227 427 320 384 2098 227 279 245 575 172 309 152 M15224 GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. 19/42 Gene Ontology BP GO:0061298 8.23594169608167e-07 3.83930494928787e-06 310 553.818181818182 310 7.48722252663502e-08 69 2.40181038237352 2.29770100797278 1 15.4090254083049 69 579 307 402 2477 80 91 919 626 310 232 153 M16477 GO_INNERVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNERVATION.html The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. 7/39 Gene Ontology BP GO:0060384 1.13520631399976e-07 1.30788161684886e-06 85 754.363636363636 310 1.13520637199097e-08 5 2.50179089331824 2.50179089331824 1 17.4365184333218 84 717 4570 310 1400 18 90 69 453 582 5 154 M14448 GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. 15/36 Gene Ontology BP GO:0060351 4.65919363072672e-05 9.2171435992604e-05 30 493.818181818182 311 4.23572027887942e-06 29 2.17334993236404 2.17334993236404 1 10.3895005740152 29 311 487 501 2499 121 98 537 203 254 392 155 M13997 GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. 28/57 Gene Ontology BP GO:0045992 1.10596145354011e-06 4.71531591256818e-06 115 382.909090909091 312 1.00542000865283e-07 112 2.21081853577009 2.34170963951998 1 13.9499354377037 192 115 312 112 1076 249 339 607 554 302 354 156 M11112 GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE.html A process that modulates the size of a cellular component. 206/480 Gene Ontology BP GO:0032535 5.54525404935079e-08 8.29891725982205e-07 280 439.818181818182 313 5.04114017192983e-09 160 1.72085675431963 1.7938888088331 1 12.3964186884759 280 632 242 160 381 193 313 714 1378 358 187 157 M14391 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND.html The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. 11/35 Gene Ontology BP GO:0050910 2.14048976659535e-05 4.7167982849085e-05 90 474 313 1.94591872070177e-06 87 2.37052802245625 2.55986121885254 1 12.1491265684819 87 591 468 401 2183 108 251 411 226 313 175 158 M15980 GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. 32/73 Gene Ontology BP GO:0051057 9.66518246077157e-09 1.96822114760361e-07 230 379.909090909091 316 8.78652954839386e-10 89 2.25789479857103 2.49122527177723 1 17.9366167041828 228 554 205 89 316 753 703 287 424 146 474 159 M16290 GO_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of dendrite development. 76/194 Gene Ontology BP GO:0050773 1.78269270255538e-06 6.54417064190877e-06 75 449.090909090909 318 1.62063104281765e-07 55 1.98079757454275 2.08686696751323 1 12.1645293228758 72 1533 634 391 1172 55 68 112 483 318 102 160 M12312 GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of adenylate cyclase activity. 21/86 Gene Ontology BP GO:0045761 2.13279326797506e-07 1.8810845092294e-06 265 930.090909090909 321 1.93890315885368e-08 85 1.45573713994581 1.55308279057765 1 9.8737326572667 264 296 998 1515 321 85 86 1762 3097 1682 125 161 M13035 GO_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_GROWTH.html Any process that modulates the frequency, rate, extent or direction of cell growth. 238/558 Gene Ontology BP GO:0001558 5.24549945304533e-08 7.95910260146715e-07 325 571.727272727273 321 4.7686359801043e-09 40 1.84522636843649 2.0241863090291 1 13.3320216142559 321 1730 240 820 600 103 653 145 1457 180 40 162 M14400 GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein homooligomerization. 10/19 Gene Ontology BP GO:0032462 1.4942027901451e-07 1.52810210454707e-06 510 515.363636363636 323 1.35836626511712e-08 101 1.58001241913933 -1.91268353109435 -1 10.8855795209919 506 164 1122 914 211 101 177 323 561 1374 216 163 M10205 GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 11/30 Gene Ontology BP GO:0035588 1.51552337458045e-07 1.53788119794373e-06 180 537.454545454545 324 1.37774861725542e-08 25 1.94563204287606 1.94563204287606 1 13.398150405545 180 324 822 683 215 36 27 787 1832 981 25 164 M13518 GO_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_GROWTH.html The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. 39/100 Gene Ontology BP GO:0035265 1.06108153012083e-06 4.57862597058646e-06 200 458.363636363636 324 9.64620038082897e-08 125 2.05692288286692 2.10349683337367 1 13.0100066331706 196 900 473 301 970 140 125 1090 341 324 182 165 M14237 GO_REGULATION_OF_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. 248/729 Gene Ontology BP GO:0044057 1.38402076275235e-15 9.83393808424846e-14 95 373.454545454545 325 1.25820069341123e-16 60 1.89642242944371 2.0583650364811 1 29.2212910265481 121 368 60 571 325 94 340 527 1441 95 166 166 M16902 GO_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a synapse. 39/123 Gene Ontology BP GO:0007416 9.44364361756303e-08 1.19473671161703e-06 175 307.727272727273 325 8.58513092994331e-09 108 1.8485356291231 1.88923054541896 1 12.9696317116739 173 269 355 245 108 409 392 530 182 325 397 167 M11062 GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. 15/37 Gene Ontology BP GO:0035025 1.79517680423149e-06 6.56816855953254e-06 330 372.181818181818 326 1.63198024461682e-07 83 2.33695683198996 2.51449308709412 1 14.3473839387753 83 455 326 99 1187 313 332 624 166 179 330 168 M13572 GO_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION.html A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. 102/242 Gene Ontology BP GO:0007369 1.09115496196837e-08 2.20270977757354e-07 75 422 328 9.91959061254796e-10 75 2.05563226358115 2.13291235640676 1 16.2108141191649 75 390 207 328 596 173 317 338 1459 532 227 169 M13677 GO_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. 311/798 Gene Ontology BP GO:0035295 4.24002667375738e-18 5.18064311743566e-16 330 435.636363636364 329 3.8545697034158e-19 20 1.82365505938392 1.88893932560078 1 33.0220271243405 329 209 37 143 72 505 623 997 1157 20 700 170 M16560 GO_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_AGGREGATION.html The adhesion of one platelet to one or more other platelets via adhesion molecules. 30/83 Gene Ontology BP GO:0070527 7.57588424868748e-08 1.02572947949697e-06 185 365 329 6.88716773597219e-09 64 2.58370532875063 2.87302132248982 1 18.3304435793783 181 433 566 799 69 64 185 314 350 725 329 171 M13192 GO_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE.html Any process that modulates the frequency or rate of heart contraction. 58/161 Gene Ontology BP GO:0002027 2.31833964080478e-10 6.6444758964547e-09 195 549.272727272727 331 2.10758149186281e-11 150 2.26252850699064 2.49068844816789 1 21.9176893180285 193 773 150 249 1267 331 306 1257 634 273 609 172 M13461 GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of dendrite development. 48/107 Gene Ontology BP GO:1900006 1.75025617460384e-06 6.46494782711663e-06 50 537.727272727273 332 1.59114324278038e-07 39 2.01235323579256 2.08171341572866 1 12.3709295463774 48 1539 1041 720 1220 79 39 87 332 650 160 173 M13107 GO_REGULATION_OF_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ORGANIZATION.html Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 69/183 Gene Ontology BP GO:0050807 6.92222020007962e-07 3.47082811975915e-06 145 456.272727272727 334 6.29292943466551e-08 50 1.81929305954095 1.96501894233251 1 11.7662722733196 142 1073 443 593 1265 110 117 50 627 265 334 174 M15988 GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 40/141 Gene Ontology BP GO:0030801 2.14371626131088e-08 3.94971214335969e-07 335 599 335 1.94883298381782e-09 9 1.71653786436003 1.89410493511677 1 13.0210020896884 335 273 383 368 9 188 254 945 2859 825 150 175 M14199 GO_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSSIFICATION.html The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. 166/459 Gene Ontology BP GO:0001503 2.63671755913421e-07 2.07508518573853e-06 340 519.181818181818 336 2.3970162501336e-08 258 1.82140417594895 1.87299001571972 1 12.2619426430766 336 960 279 275 472 333 507 681 1319 291 258 176 M15889 GO_SKIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_DEVELOPMENT.html The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. 118/353 Gene Ontology BP GO:0043588 7.87307770868512e-17 7.310939960285e-15 480 353.545454545455 336 7.15734337153193e-18 30 2.29178497760304 2.47129063225903 1 38.3777324022939 479 521 47 30 250 626 802 334 336 39 425 177 M10607 GO_INTERMEDIATE_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_ORGANIZATION.html Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 12/32 Gene Ontology BP GO:0045109 2.3747379284149e-06 8.01301468141744e-06 170 446 337 2.1588549925213e-07 78 2.57982251629199 2.50506956528224 1 15.5745208079444 170 589 337 351 1591 106 78 876 202 363 243 178 M16303 GO_PENTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. 6/18 Gene Ontology BP GO:0019321 1.4649212643711e-06 5.76656072488019e-06 300 1147.27272727273 341 1.46492223006944e-07 7 1.24443588997116 -1.24443588997116 -1 7.72335192520223 296 341 4544 2151 1822 88 7 104 817 2201 249 179 M11226 GO_MORPHOGENESIS_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIUM.html The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. 242/611 Gene Ontology BP GO:0002009 7.34681467226053e-19 1.13704201744352e-16 30 412.727272727273 342 6.67892242932772e-20 21 1.97052048798716 2.05347879358828 1 37.2188037083624 342 21 29 28 155 639 827 1184 574 28 713 180 M10429 GO_SINGLE_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BEHAVIOR.html The specific behavior of a single organism in response to external or internal stimuli. 185/632 Gene Ontology BP GO:0044708 1.83371495729284e-07 1.73047531437208e-06 270 421.909090909091 343 1.66701373648568e-08 157 1.75415539249449 1.98625164504386 1 11.9731077286578 276 513 268 521 268 209 366 343 1193 157 527 181 M12413 GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 42/99 Gene Ontology BP GO:0070167 2.45994457928833e-07 2.00203502611962e-06 420 329.090909090909 343 2.23631350395338e-08 68 2.05535450926635 2.2494593448344 1 13.8748245716864 418 271 400 168 371 581 343 68 308 488 204 182 M13364 GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. 17/41 Gene Ontology BP GO:0048485 3.48507291618158e-06 1.06245525606245e-05 395 549.181818181818 343 3.16825312452878e-07 119 2.59818228638971 2.88787969028432 1 15.3082775571315 395 827 659 343 1428 242 250 225 316 1237 119 183 M16913 GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 113/273 Gene Ontology BP GO:0010770 1.99783186429721e-06 7.14082628632173e-06 245 496.090909090909 344 1.81621243503764e-07 227 1.79476732646358 2.06594746435202 1 10.9415084183991 242 755 344 379 1209 318 568 254 890 227 271 184 M15544 GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH.html Any process that modulates the extent of cell growth. 66/153 Gene Ontology BP GO:0061387 4.561440159474e-07 2.78667982374181e-06 95 401.818181818182 345 4.14676464112274e-08 57 1.84489179009702 2.01747778050247 1 12.1402098968898 93 1241 346 365 611 72 293 91 906 345 57 185 M13908 GO_NEUROGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROGENESIS.html Generation of cells within the nervous system. 683/1999 Gene Ontology BP GO:0022008 1.17432115339587e-09 3.01236083713648e-08 350 755 347 1.17432115401643e-10 44 1.76660028870639 1.94448678005463 1 15.7397312115256 347 354 4153 347 217 252 770 303 1313 44 205 186 M11811 GO_FOREBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 187/610 Gene Ontology BP GO:0030900 4.65848059943939e-09 1.04489494798054e-07 410 461.272727272727 348 4.23498237209426e-10 85 1.92319886607671 2.01475903181128 1 15.9043296810823 408 746 189 177 918 273 592 85 1225 348 113 187 M11740 GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 169/414 Gene Ontology BP GO:0051961 3.01406113682088e-10 8.43029268569839e-09 210 411.454545454545 350 2.74005557930347e-11 154 2.00447000067136 2.28354797564195 1 19.1723272383662 207 377 154 219 774 360 742 169 929 350 245 188 M14241 GO_RESPONSE_TO_BMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 44/151 Gene Ontology BP GO:0071772 4.11769503087062e-07 2.61980478260637e-06 355 278.272727272727 351 3.74335981961036e-08 13 2.24392932909648 2.42525687864927 1 14.8373429672455 24 411 352 536 876 13 36 35 359 351 68 189 M15229 GO_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. 472/1348 Gene Ontology BP GO:0030030 1.66807717851491e-07 1.62026827193405e-06 425 431.545454545455 352 1.51643391362851e-08 5 1.59528316243692 1.72258570736535 1 10.9427219104631 425 5 340 352 244 152 666 479 1360 379 345 190 M13576 GO_SKIN_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. 45/111 Gene Ontology BP GO:0098773 2.37043921228259e-07 1.9759334403282e-06 325 361.636363636364 353 2.1549449706281e-08 272 2.43948061608157 2.5948993032819 1 16.4843672454128 353 544 272 299 447 361 324 324 323 376 355 191 M15778 GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 44/151 Gene Ontology BP GO:0071773 4.54141558113186e-07 2.77810178434719e-06 355 279.909090909091 353 4.12856047146125e-08 14 2.24392932909648 2.42525687864927 1 14.769614156045 25 412 353 537 877 14 37 42 360 353 69 192 M16602 GO_NEURAL_CREST_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. 40/108 Gene Ontology BP GO:0014033 1.11184779526559e-09 2.86794961856564e-08 225 400.272727272727 353 1.01077072347955e-10 95 2.02516291536441 2.28958494199725 1 18.0946100477193 221 95 167 208 353 519 428 797 979 423 213 193 M13006 GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS.html The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 78/326 Gene Ontology BP GO:0050953 3.35903716257307e-06 1.03490441578147e-05 355 513.545454545455 355 3.05367481025435e-07 67 1.82972635328755 2.06705754122491 1 10.8053298995906 355 67 388 860 1412 265 520 307 811 346 318 194 M14540 GO_RESPONSE_TO_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 294/708 Gene Ontology BP GO:0070848 1.09661051353903e-09 2.86042843503468e-08 315 437.636363636364 355 9.96918649168773e-11 107 1.8209714267868 1.94806641303687 1 16.2726412563794 314 627 165 107 355 235 422 612 1301 224 452 195 M14110 GO_BLOOD_VESSEL_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_REMODELING.html The reorganization or renovation of existing blood vessels. 20/45 Gene Ontology BP GO:0001974 2.94516035553768e-06 9.35320077343463e-06 225 551.272727272727 357 2.67742208932589e-07 111 2.45111462281666 2.58867612122233 1 14.6024840407893 222 920 357 265 1883 527 554 111 547 343 335 196 M15406 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 615/1669 Gene Ontology BP GO:0051094 2.30468468279871e-17 2.48852348424056e-15 360 809.909090909091 359 2.30468468279871e-18 4 1.80811126428225 1.96108200628341 1 31.2807233125886 359 356 4400 131 199 501 744 288 1447 4 480 197 M16144 GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 75/173 Gene Ontology BP GO:0010811 3.98323390421185e-12 1.47953240138045e-10 120 454.454545454545 359 3.62112173110825e-13 62 1.93150204488141 2.08635763238165 1 22.4916470455266 297 62 116 210 359 718 704 583 965 118 867 198 M11775 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of hair follicle development. 7/18 Gene Ontology BP GO:0051797 2.32782138119771e-06 7.90641892677468e-06 490 722.545454545455 362 2.32782381963988e-07 20 3.31239349837248 3.4320743413189 1 20.0199118353839 487 849 3802 70 1312 270 20 362 60 578 138 199 M14729 GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. 105/287 Gene Ontology BP GO:0001763 7.55222408288168e-14 3.85329411173842e-12 80 406.909090909091 362 6.86565825716539e-15 46 2.13027843278928 2.22007649587478 1 28.8043912457822 362 46 85 78 221 663 869 911 422 80 739 200 M11140 GO_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING.html Any process that mediates the transfer of information from one cell to another. 311/1050 Gene Ontology BP GO:0007267 5.87511462103007e-20 1.01030211797936e-17 30 449.363636363636 363 5.3410132918455e-21 26 1.88475055783896 2.0051892864832 1 37.9461006377979 268 363 26 406 583 195 589 918 1350 26 219 201 M12438 GO_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 86/203 Gene Ontology BP GO:0043279 1.2003084349575e-06 4.9965450210294e-06 90 477.636363636364 367 1.0911900816727e-07 43 1.84735525971591 1.95689932776815 1 11.6014778548531 187 644 367 380 1015 90 224 86 1489 729 43 202 M14503 GO_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 258/735 Gene Ontology BP GO:0042493 1.06458309322268e-15 7.72321765911389e-14 315 516 367 9.67802812020612e-17 59 1.92100118962452 2.21154793831669 1 29.8387985926134 311 367 59 158 1257 692 918 235 1030 211 438 203 M11956 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. 190/470 Gene Ontology BP GO:0032970 4.59931081891798e-07 2.78730492769333e-06 275 463.545454545455 368 4.18119252768024e-08 96 1.74535060539948 1.84144093210387 1 11.4849830632614 271 227 313 96 617 368 273 387 1448 476 623 204 M12499 GO_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPROUTING_ANGIOGENESIS.html The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. 25/83 Gene Ontology BP GO:0002040 4.30936348357035e-07 2.70268065982377e-06 135 396.727272727273 368 3.91760393426308e-08 35 1.9124221229445 1.86041596572089 1 12.6147032758505 134 677 558 184 587 109 130 368 1041 541 35 205 M15086 GO_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 7/21 Gene Ontology BP GO:0010463 2.62285482186368e-09 6.33727315807646e-08 335 1002.45454545455 370 2.62285482495939e-10 3 3.0226988036749 3.0226988036749 1 25.7745253824113 334 720 4346 821 2445 292 370 3 35 1510 151 206 M12034 GO_AORTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_DEVELOPMENT.html The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. 38/106 Gene Ontology BP GO:0035904 3.71700934711852e-06 1.11678460702133e-05 115 531.909090909091 371 3.37910511564128e-07 112 2.31359196475515 2.41557841552154 1 13.5721338197739 112 1085 371 342 1451 541 692 166 305 230 556 207 M15342 GO_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_GROWTH.html Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 28/75 Gene Ontology BP GO:0060420 1.72089217163497e-06 6.39323889408018e-06 375 571.818181818182 371 1.56444865250828e-07 119 2.81160886782237 3.12069646315279 1 17.3004835802091 371 1478 538 119 1157 439 290 127 302 1103 366 208 M12564 GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS.html The cellular component assembly that is part of the initial shaping of the component during its developmental progression. 147/381 Gene Ontology BP GO:0010927 6.86700202101825e-08 9.63247443612922e-07 250 383.363636363636 372 6.24272930487494e-09 60 1.79695617900506 1.94709842998021 1 12.8068487863198 246 379 655 255 60 150 408 353 616 723 372 209 M14835 GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). 19/87 Gene Ontology BP GO:0007193 1.86918298896009e-07 1.73572332354834e-06 255 994.363636363636 372 1.69925740706477e-08 166 2.01832574596312 2.01832574596312 1 13.7730765073621 255 1801 1264 1830 283 320 166 372 2385 2026 236 210 M13025 GO_CELL_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGGREGATION.html The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. 17/45 Gene Ontology BP GO:0098743 2.44181955915894e-07 1.99953584006613e-06 380 446.090909090909 378 2.21983620925538e-08 136 2.26094419001592 2.40441503353191 1 15.2641262285984 378 136 274 166 820 508 779 916 215 233 482 211 M11163 GO_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of muscle contraction. 89/232 Gene Ontology BP GO:0006937 1.26755103860865e-07 1.3946065100142e-06 260 575.545454545455 379 1.15231919239983e-08 59 1.76874734517151 1.93366480538047 1 12.2690634280555 257 59 379 586 165 197 382 1255 1751 969 331 212 M16745 GO_CARTILAGE_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_CONDENSATION.html The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. 17/45 Gene Ontology BP GO:0001502 2.44181955915894e-07 1.99953584006613e-06 380 447.090909090909 379 2.21983620925538e-08 137 2.26094419001592 2.40441503353191 1 15.2641262285984 379 137 275 167 821 509 780 917 216 234 483 213 M16818 GO_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_CIRCULATION.html Any process that modulates the frequency, rate or extent of blood circulation. 141/435 Gene Ontology BP GO:1903522 1.00422563177867e-12 4.0900172003056e-11 190 477.181818181818 379 9.12932392526487e-14 105 1.87356059280475 1.99938298345101 1 23.0562804085958 190 233 105 470 505 196 379 1245 1329 125 472 214 M10398 GO_CELL_PART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PART_MORPHOGENESIS.html The process in which the anatomical structures of a cell part are generated and organized. 338/988 Gene Ontology BP GO:0032990 1.12936271907986e-07 1.30763867947327e-06 290 402.818181818182 380 1.02669343368666e-08 11 1.57049250097468 1.69936213709707 1 10.9458769933203 286 11 382 471 141 118 515 604 1212 380 311 215 M15272 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. 15/52 Gene Ontology BP GO:0001937 5.51330438305094e-06 1.51558746302578e-05 175 650.181818181818 383 5.01210745427435e-07 44 2.13990240226387 2.13990240226387 1 12.2170596200928 174 1422 852 445 2506 231 44 154 228 713 383 216 M13989 GO_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSPORT.html The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 97/297 Gene Ontology BP GO:0006816 8.51527703818925e-08 1.11370228981163e-06 300 604.272727272727 385 7.7411612434363e-09 89 1.73683444861323 1.79684246107781 1 12.2486772938399 298 641 385 1162 89 213 402 523 2313 327 294 217 M16868 GO_CELLULAR_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 22/52 Gene Ontology BP GO:0071312 2.54384133073459e-07 2.04343517276828e-06 385 393.363636363636 385 2.31258329534259e-08 99 2.25386872424911 2.19588858401534 1 15.1911759147122 254 444 505 425 385 330 384 580 363 558 99 218 M12477 GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 53/128 Gene Ontology BP GO:0071300 3.25645142527664e-10 9.05371495063438e-09 65 414 386 2.96041038705333e-11 63 2.21012944002138 2.21998631046629 1 21.0582945731918 63 537 155 386 834 349 291 501 756 134 548 219 M16952 GO_POSITIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSSIFICATION.html Any process that activates or increases the frequency, rate or extent of bone formation. 57/117 Gene Ontology BP GO:0045778 2.07191865463031e-08 3.86889012325632e-07 380 455.181818181818 386 1.88356243103932e-09 5 1.97605913763622 2.14623434951422 1 15.0106506461286 376 260 423 323 5 862 328 1059 446 386 539 220 M11227 GO_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DIFFERENTIATION.html The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. 104/262 Gene Ontology BP GO:0001649 1.89978194211189e-07 1.74321888482718e-06 270 610.727272727273 388 1.72707464196832e-08 55 1.80782802191367 1.7990668743183 1 12.3326297984235 269 2050 623 346 292 135 388 463 1464 633 55 221 M11568 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of epithelial cell proliferation. 98/243 Gene Ontology BP GO:0050679 2.6985794066562e-09 6.45850731190967e-08 210 589.181818181818 388 2.45325400906032e-10 178 1.91249383648551 2.15454745721775 1 16.2891719882286 721 388 178 300 210 1161 1113 336 1001 208 865 222 M14953 GO_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 17/46 Gene Ontology BP GO:0010226 7.24751235253268e-06 1.89578590720052e-05 390 781 390 6.58866929845018e-07 101 3.91034111825401 3.91034111825401 1 21.8744969737291 390 2197 637 451 2068 253 305 174 101 1800 215 223 M13755 GO_ENDODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. 46/113 Gene Ontology BP GO:0007492 6.15078462548956e-09 1.31604115281788e-07 130 511.272727272727 393 5.59162240244183e-10 92 2.13344400960785 2.36892750364335 1 17.38977085075 126 92 197 258 1411 475 192 656 1282 393 542 224 M12404 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 249/586 Gene Ontology BP GO:0044089 4.47250252724608e-08 6.94509338929884e-07 780 674 396 4.06591147106369e-09 84 1.78092200086179 2.02451342543938 1 12.9922787936339 779 215 237 84 369 1787 1106 221 960 396 1260 225 M12965 GO_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 31/83 Gene Ontology BP GO:0061383 1.98915356698364e-06 7.12626544097611e-06 75 452.363636363636 399 1.80832305954584e-07 73 2.2451718427918 2.42544693116904 1 13.6896847758135 73 423 331 530 1494 286 485 206 399 495 254 226 M10301 GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 204/507 Gene Ontology BP GO:0010721 5.90516358967224e-11 1.89087410667919e-09 325 437.818181818182 400 5.36833053620977e-12 134 1.89832327701646 2.14897308850999 1 19.6169238905801 322 223 134 217 400 566 760 427 973 304 490 227 M16924 GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. 154/418 Gene Ontology BP GO:0043062 6.88047457164479e-27 6.38920868722935e-24 30 425.090909090909 403 6.25497688331345e-28 5 2.11748454428982 2.30721414921685 1 58.1814236834009 28 30 5 668 1101 403 685 354 820 11 571 228 M16833 GO_CARDIAC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. 37/93 Gene Ontology BP GO:0055006 8.22011132332237e-08 1.08928103117624e-06 205 348.363636363636 406 7.47282875496346e-09 79 2.3845822081483 2.50019988266939 1 16.8439899913253 204 668 490 281 79 127 116 456 406 569 436 229 M14176 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a ventricular cardiac muscle cell. 7/30 Gene Ontology BP GO:0086005 5.23961363277525e-08 7.95910260146715e-07 410 804.363636363636 410 5.23961375631622e-09 47 1.79484171681858 -1.77473364669931 -1 12.9679853308923 984 172 4198 410 47 582 833 406 271 192 753 230 M14929 GO_HEART_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_PROCESS.html A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 63/167 Gene Ontology BP GO:0003015 2.88379749116213e-07 2.19492466551396e-06 585 554.454545454545 410 2.62163442652299e-08 76 2.16759122636815 2.65035940212801 1 14.5299100378264 582 76 315 211 422 705 410 1665 260 298 1155 231 M10386 GO_COGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COGNITION.html The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. 123/419 Gene Ontology BP GO:0050890 9.32008390526123e-08 1.18752475577845e-06 340 485.909090909091 413 8.47280390917949e-09 106 1.66898322116158 1.79551114611855 1 11.7150610316299 339 383 827 261 106 357 499 724 1009 427 413 232 M12344 GO_NEPHRIC_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. 16/29 Gene Ontology BP GO:0072176 5.07284788663495e-07 2.91500405168887e-06 170 440.181818181818 415 4.61168096032078e-08 59 1.6315079124452 1.80250433778302 1 10.6982601522481 168 925 981 609 663 159 72 59 655 415 136 233 M13352 GO_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULUS_DEVELOPMENT.html The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. 36/90 Gene Ontology BP GO:0032835 5.72353325790488e-12 2.10907658067082e-10 35 558.272727272727 415 5.20321205265434e-13 31 2.42200316626831 2.6508361833104 1 27.7616002661121 31 415 117 474 2235 223 319 937 541 201 648 234 M16001 GO_POSITIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 65/178 Gene Ontology BP GO:0050921 4.56343061261163e-06 1.3043326921893e-05 180 936.090909090909 415 4.14858188954753e-07 179 1.73855096155291 1.80259090967422 1 10.0599423720696 179 2386 415 1631 1527 189 348 419 2555 263 385 235 M15679 GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 96/308 Gene Ontology BP GO:0006140 6.91519718367129e-08 9.64181997711286e-07 415 742 416 6.28654309184974e-09 61 1.48400463044982 1.58220635377812 1 10.5757125125361 415 246 588 663 61 300 416 734 3009 1443 287 236 M15294 GO_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_FORMATION.html The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 16/51 Gene Ontology BP GO:0060343 4.97617250674352e-06 1.39603437757161e-05 75 494.181818181818 417 4.52380342033346e-07 71 2.10319015423144 2.24607485139291 1 12.0963712820913 71 304 359 374 1699 250 470 543 442 417 507 237 M11764 GO_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. 61/145 Gene Ontology BP GO:0019722 2.70210409870238e-07 2.10849698183809e-06 265 586.363636363636 418 2.45645857325703e-08 114 2.17451633913904 2.13304549452768 1 14.6212728251209 114 1075 282 418 1444 148 262 860 1022 564 261 238 M14858 GO_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a second cell of the identical type via adhesion molecules. 40/108 Gene Ontology BP GO:0034109 7.48357562403129e-08 1.01895136722514e-06 425 437.454545454545 418 6.80325079872229e-09 68 2.48195355461932 2.59426643404058 1 17.6170177764953 423 418 438 318 68 120 309 1270 352 543 553 239 M10257 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 144/369 Gene Ontology BP GO:0090287 6.56719654754877e-07 3.37668810301982e-06 330 639.090909090909 423 5.97018046174222e-08 270 1.80753218593906 1.81900215433144 1 11.7157798074136 306 1529 330 270 778 393 670 665 1337 329 423 240 M13215 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). 248/1835 Gene Ontology BP GO:0007186 3.57202241105594e-16 2.94651581774701e-14 185 816.363636363636 424 3.24729310095994e-17 52 1.752452088998 1.7943045741986 1 28.0895131772403 182 1060 52 1777 289 370 424 1323 2745 152 606 241 M15117 GO_EPITHELIAL_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MORPHOGENESIS.html The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. 28/69 Gene Ontology BP GO:0003382 1.87402217017502e-11 6.59173101221411e-10 4480 1887.72727272727 424 1.70365651835544e-12 10 2.07099332763805 -2.16014063651932 -1 22.5240654716746 4478 109 123 10 424 4241 3996 2334 318 126 4606 242 M16337 GO_AXONAL_FASCICULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_FASCICULATION.html The collection of axons into a bundle of rods, known as a fascicle. 14/43 Gene Ontology BP GO:0007413 1.6439683730849e-07 1.61692190219132e-06 425 924.363636363636 424 1.49451681448348e-08 153 1.81348842862903 2.06045166285884 1 12.4414132625866 424 2226 1281 1739 234 412 153 283 1725 1400 291 243 M13527 GO_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. 32/126 Gene Ontology BP GO:0021675 6.97899059008805e-07 3.49175143424341e-06 45 367 425 6.34453891273835e-08 17 2.04487006501324 2.13724053418799 1 13.2188681217407 42 425 575 438 936 17 25 51 642 849 37 244 M15904 GO_PATTERN_SPECIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_SPECIFICATION_PROCESS.html Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. 210/609 Gene Ontology BP GO:0007389 1.0422183058003e-07 1.26675905597665e-06 320 617.181818181818 425 9.47471231976264e-09 124 1.82304531189779 1.88935625609694 1 12.735886184415 317 1308 267 1137 124 284 354 425 1529 609 435 245 M12381 GO_PATTERNING_OF_BLOOD_VESSELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERNING_OF_BLOOD_VESSELS.html The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. 30/76 Gene Ontology BP GO:0001569 9.1694774876808e-06 2.29756524421489e-05 105 497.727272727273 426 8.33592336888669e-07 102 2.22708494855018 2.2990030780013 1 12.2381034692691 102 432 426 241 1732 181 274 603 788 449 247 246 M10268 GO_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 497/1356 Gene Ontology BP GO:0060429 8.06725198452873e-33 1.24854169880556e-29 5 380.727272727273 428 7.33386544048066e-34 3 1.985643685507 2.09952741199408 1 67.9878491998349 428 199 3 3 84 442 940 705 822 8 554 247 M15274 GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that activates or increases the frequency, rate or extent of blood circulation. 44/135 Gene Ontology BP GO:1903524 1.04707712101927e-06 4.53928951717317e-06 255 719.545454545455 430 9.51888744881663e-08 183 1.83217454094801 1.82843853067716 1 11.5966097328817 252 662 376 798 964 218 183 1599 2108 430 325 248 M15828 GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. 80/235 Gene Ontology BP GO:0060041 9.95045617337275e-10 2.6399981721697e-08 185 427.090909090909 430 9.04586925261204e-11 162 1.97839000533372 2.08777202707713 1 17.7609947693263 185 395 162 430 636 356 541 430 863 182 518 249 M11503 GO_KIDNEY_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 68/192 Gene Ontology BP GO:0072073 2.27435471472704e-09 5.56906153308588e-08 435 371.181818181818 432 2.06759519734388e-10 40 1.92677114182714 2.08581538061143 1 16.5576535888303 432 252 175 52 40 515 439 1037 473 148 520 250 M13864 GO_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MIGRATION.html The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. 63/181 Gene Ontology BP GO:0001764 1.27094318767226e-08 2.50216296490983e-07 320 450.454545454545 434 1.15540290455865e-09 1 1.90675280183974 2.04868340402634 1 14.9117016239861 319 648 491 434 1021 142 202 23 967 707 1 251 M12057 GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 48/106 Gene Ontology BP GO:0010812 3.47459678835098e-06 1.06151839136267e-05 30 518.181818181818 435 3.15872934182714e-07 30 1.75251098442758 1.78773952681358 1 10.3264462474228 30 265 546 502 1424 194 61 647 1208 435 388 252 M13356 GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. 15/46 Gene Ontology BP GO:0086019 3.57001300445222e-06 1.07843658943862e-05 240 616.181818181818 436 3.24547163422177e-07 187 2.2190336803787 2.09918212487978 1 13.0573202944392 240 1006 462 625 1439 314 187 1327 436 375 367 253 M12574 GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. 24/49 Gene Ontology BP GO:0036296 1.94385175889945e-05 4.34326454117909e-05 395 600.090909090909 437 1.7671535767119e-06 200 1.93679925733123 2.15332984500655 1 10.0084446323392 200 437 394 393 1985 420 706 658 580 279 549 254 M13343 GO_PALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. 98/287 Gene Ontology BP GO:0021543 2.13862860469207e-07 1.8810845092294e-06 330 485.545454545455 437 1.94420801144457e-08 11 1.90499050757528 2.03757816892968 1 12.9208544769656 330 761 475 403 1215 117 437 26 1028 538 11 255 M15782 GO_RESPONSE_TO_HYPEROXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYPEROXIA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. 24/49 Gene Ontology BP GO:0055093 1.94385175889945e-05 4.34326454117909e-05 395 600.090909090909 438 1.7671535767119e-06 201 1.93679925733123 2.15332984500655 1 10.0084446323392 201 438 395 394 1986 421 707 648 581 280 550 256 M11382 GO_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins. 22/47 Gene Ontology BP GO:0097435 3.63816519934479e-05 7.402279150113e-05 445 530.363636363636 442 3.30747760499307e-06 66 2.28129719367083 2.25105307505595 1 11.1628907619445 66 442 518 610 2154 139 155 444 572 408 326 257 M12995 GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of cell junction assembly. 21/50 Gene Ontology BP GO:1901890 3.46072278225199e-06 1.05850697483504e-05 210 689.909090909091 443 3.14611656924914e-07 140 2.13992901871619 2.12126112124924 1 12.6123853833798 206 443 345 727 2307 437 140 847 896 276 965 258 M11440 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. 166/433 Gene Ontology BP GO:0030111 1.38927497471452e-05 3.25449228435898e-05 445 677.454545454545 444 1.26298522536865e-06 137 1.97841290108113 2.04052647749829 1 10.517222226764 308 1458 507 444 1880 303 441 417 966 591 137 259 M16954 GO_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of vasculature development. 147/372 Gene Ontology BP GO:1901342 5.37948124144123e-15 3.42149745260433e-13 70 597 445 4.89043749221931e-16 68 1.90243557169597 1.94994306389558 1 28.0936147854256 70 519 68 1016 1024 369 445 402 1953 139 562 260 M15331 GO_FLAVONOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVONOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. 4/29 Gene Ontology BP GO:0009812 6.57808425374535e-08 9.31159914333526e-07 5 960.272727272727 446 6.57808444846572e-09 3 3.55389468427202 3.55389468427202 1 25.3904388537291 446 1524 4389 55 1563 597 239 31 5 1711 3 261 M10415 GO_SKELETAL_MUSCLE_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_TISSUE_REGENERATION.html The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. 23/42 Gene Ontology BP GO:0043403 2.10245390723311e-07 1.86648059106755e-06 395 643.818181818182 453 1.91132191650584e-08 22 1.93222769732321 1.83232854701944 1 13.113342111542 393 1096 1192 453 317 149 119 973 1589 779 22 262 M13165 GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. 49/157 Gene Ontology BP GO:0055007 1.37249677672747e-07 1.45174832762246e-06 185 500.090909090909 453 1.24772442032033e-08 100 2.36787138490545 2.39971536475481 1 16.3760192663897 184 973 529 979 188 100 132 421 688 854 453 263 M11002 GO_SINGLE_ORGANISM_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELL_ADHESION.html The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. 262/734 Gene Ontology BP GO:0098602 7.48607432427655e-22 1.7378921543808e-19 455 463.090909090909 454 6.80552211297869e-23 13 1.93825858793841 2.18595244199612 1 43.0746847136747 454 629 19 13 352 721 1011 359 1008 49 479 264 M11366 GO_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_ASSEMBLY.html The aggregation, arrangement and bonding together of the extracellular matrix. 14/22 Gene Ontology BP GO:0085029 3.79169631204957e-06 1.1305000062821e-05 380 747.272727272727 454 3.44700258822507e-07 125 3.1582282026531 3.53575600030055 1 18.5071577258673 377 1272 820 1000 1959 454 238 125 160 1385 430 265 M16753 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. 9/16 Gene Ontology BP GO:2000727 2.03709151388159e-06 7.23658446744621e-06 260 1179.90909090909 458 2.03709338126782e-07 96 2.57660629861253 2.57660629861253 1 15.6902058346465 258 2931 4616 1154 1295 329 272 96 458 1213 357 266 M16714 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. 14/36 Gene Ontology BP GO:0043206 8.09763325483818e-05 0.000149909534299097 45 596.090909090909 459 7.36175574837959e-06 45 2.38747881009065 2.38747881009065 1 10.8157050336104 45 697 467 608 2408 241 315 634 349 334 459 267 M11847 GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 52/124 Gene Ontology BP GO:0006023 5.52361851464163e-06 1.51752430553142e-05 55 713.727272727273 460 5.02148398457865e-07 52 1.77706284246705 1.77309969202748 1 10.1443801695065 52 264 460 1714 1589 294 216 365 1486 797 614 268 M12273 GO_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_PAIN.html The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. 38/149 Gene Ontology BP GO:0019233 2.99129659248857e-07 2.22573558957122e-06 725 588.545454545455 460 2.71936090837213e-08 167 1.93828330703055 2.13626947640326 1 12.9789004871069 407 978 446 724 435 460 584 332 1219 722 167 269 M16002 GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rho protein signal transduction. 57/144 Gene Ontology BP GO:0035023 2.69847582430215e-07 2.10849698183809e-06 460 747.909090909091 460 2.45316014117439e-08 78 1.82902575471748 1.99973484047589 1 12.2982216787858 460 78 296 203 401 2184 1431 655 682 255 1582 270 M10469 GO_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_PRESSURE.html Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 89/298 Gene Ontology BP GO:0008217 6.29619232290817e-11 1.98054415237877e-09 60 749.363636363636 464 5.72381120280761e-12 57 2.66628181848584 2.87694099980019 1 27.4893114672932 57 1966 136 1145 2035 185 220 464 1068 534 433 271 M16925 GO_DIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 112/346 Gene Ontology BP GO:0072511 7.07730165867879e-08 9.80892883619272e-07 360 654.636363636364 464 6.43391080577493e-09 64 1.75201564212004 1.80291966518114 1 12.4701965787257 358 524 393 1385 64 359 514 605 2229 306 464 272 M15599 GO_KIDNEY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MORPHOGENESIS.html Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 38/117 Gene Ontology BP GO:0060993 1.11455271359068e-07 1.29695946095276e-06 1625 1254.45454545455 466 1.01322979095962e-08 138 1.74991167317452 1.98180588759209 1 12.203759356792 1623 272 457 297 138 2254 2046 3802 466 381 2063 273 M10452 GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. 47/108 Gene Ontology BP GO:0050848 2.03620273341358e-07 1.82864396348922e-06 310 817.454545454545 467 1.8510935653397e-08 276 1.76249681810818 2.18461484078456 1 11.980009172695 438 547 1040 1138 307 309 276 467 1978 2206 286 274 M10751 GO_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. 270/646 Gene Ontology BP GO:0030029 4.48499531808076e-09 1.02077614028672e-07 470 474.818181818182 467 4.07726847929456e-10 18 1.74844040047999 1.90651448479192 1 14.4801314092485 467 18 186 138 194 536 698 931 1034 181 840 275 M13575 GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. 51/151 Gene Ontology BP GO:1901343 4.00866661562032e-09 9.21397975065601e-08 55 791.454545454545 469 3.64424238447691e-10 51 2.04492942335447 2.08743081137448 1 17.0433360000732 51 1537 184 957 2564 413 373 469 1201 347 610 276 M13784 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell migration. 47/93 Gene Ontology BP GO:0014910 7.61091526883355e-07 3.66370740073268e-06 20 713 470 6.91901627439658e-08 18 1.98866523390425 2.15797807419567 1 12.8063540097988 18 1894 470 793 1814 49 163 54 1334 1172 82 277 M16051 GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE.html The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. 89/250 Gene Ontology BP GO:0048754 3.33776845395207e-13 1.50458824579606e-11 475 530 471 3.0343349581387e-14 56 2.13436074931516 2.23969166465599 1 27.3638246740833 471 56 96 77 419 1021 1210 1119 471 89 801 278 M11376 GO_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_CONTRACTION.html Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. 110/333 Gene Ontology BP GO:0008016 6.82939311584089e-10 1.82234897912927e-08 290 569.181818181818 472 6.20853919814629e-11 161 1.88121452676102 2.08659350190282 1 17.2473313063299 290 386 161 472 951 347 566 1073 1171 287 557 279 M15108 GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. 7/19 Gene Ontology BP GO:0002313 3.12528220905935e-07 2.29236734544433e-06 1210 964.545454545455 475 3.12528264859193e-08 77 2.19028667354113 -1.5724816405354 -1 14.6330963037177 1207 178 4354 436 475 234 141 1170 77 1511 827 280 M10349 GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION.html A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. 46/78 Gene Ontology BP GO:0061572 1.4794457878764e-07 1.52301086663364e-06 480 871.909090909091 478 1.34495080669591e-08 206 1.45044458429403 1.64405625925208 1 9.99540524225118 478 898 2002 969 206 279 389 443 1139 2465 323 281 M16086 GO_BASEMENT_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. 19/31 Gene Ontology BP GO:0071711 3.30423944320167e-06 1.02005211002562e-05 15 707 478 3.00385855085328e-07 13 2.19392723499089 2.30880039372176 1 12.972410828909 13 1094 342 1239 2671 178 102 697 549 414 478 282 M10576 GO_HEART_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 16/39 Gene Ontology BP GO:0061384 2.24571032371205e-08 4.1050523751949e-07 750 750.727272727273 479 2.04155486057795e-09 11 2.12459880228563 2.5050496616638 1 16.0742320456372 750 147 683 257 11 1506 2087 333 479 1610 395 283 M16139 GO_RENAL_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_FILTRATION.html A renal system process in which fluid circulating through the body is filtered through a barrier system. 3/13 Gene Ontology BP GO:0097205 2.67637884186692e-05 5.70281182321621e-05 305 1092.09090909091 480 2.67641107592998e-06 123 1.89314819411127 1.89314819411127 1 9.51763180481839 403 732 4517 480 2190 304 123 302 1206 1423 333 284 M16274 GO_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 27/68 Gene Ontology BP GO:0051489 1.86960068995771e-05 4.2097749774363e-05 415 750.272727272727 481 1.699651434872e-06 262 1.73978979388179 2.05892848535319 1 9.0183361537837 414 675 639 481 1973 354 362 262 1240 1412 441 285 M10363 GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. 126/300 Gene Ontology BP GO:0045665 1.38475448089315e-07 1.45791724598342e-06 290 563.090909090909 482 1.25886778914026e-08 263 1.95602171102611 2.26072187453717 1 13.523430704933 289 752 263 635 459 506 928 344 1174 482 362 286 M13797 GO_RESPONSE_TO_AUDITORY_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AUDITORY_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. 16/48 Gene Ontology BP GO:0010996 6.75540781636927e-08 9.53354361440807e-07 405 479.727272727273 482 6.14128002163958e-09 13 2.15689257198486 2.36485089910289 1 15.3835599738512 402 587 920 508 270 558 482 13 345 810 382 287 M16748 GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structure of the retina is generated and organized. 23/80 Gene Ontology BP GO:0060042 1.05750422421443e-07 1.27201868213151e-06 130 525.727272727273 486 9.61367522769949e-09 127 1.6290218527347 1.733602537044 1 11.3769558041027 759 128 963 486 127 649 751 401 769 446 304 288 M16350 GO_RESPONSE_TO_WATER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. 12/31 Gene Ontology BP GO:0009415 2.83718533120962e-08 4.93372715086376e-07 410 481.636363636364 487 2.57925942527163e-09 9 2.05109992773094 2.42161648282338 1 15.3241235561704 410 158 679 696 621 487 939 9 478 742 79 289 M12752 GO_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. 53/141 Gene Ontology BP GO:0060070 1.44665105682214e-07 1.49928590554134e-06 385 495.272727272727 489 1.31513741086309e-08 202 1.96428387028287 1.96067713598969 1 13.5522773301158 385 406 612 500 202 365 232 763 920 574 489 290 M14576 GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of adherens junction organization. 20/47 Gene Ontology BP GO:1903393 5.6379185452531e-06 1.54253717180967e-05 280 697.818181818182 489 5.12539363049437e-07 196 2.19680420944926 2.18764456038223 1 12.5220013604166 279 297 366 726 2260 489 196 835 900 344 984 291 M16870 GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. 111/365 Gene Ontology BP GO:0010466 4.84054907983478e-07 2.86654203278225e-06 275 640.272727272727 490 4.4005001317061e-08 246 1.8952310569623 2.04671299061874 1 12.4439142916818 490 1234 291 1075 872 272 727 274 1209 246 353 292 M16106 GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT.html The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. 4/18 Gene Ontology BP GO:0021891 3.41559207770209e-05 6.99540980007535e-05 610 1033.54545454545 492 3.41564457704936e-06 81 1.61470460015734 -1.61470460015734 -1 7.94806937160688 606 492 4508 734 2165 161 81 380 179 1714 349 293 M13921 GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. 33/112 Gene Ontology BP GO:0031644 5.18028723436899e-06 1.4428358505804e-05 80 627.272727272727 493 4.70936312027936e-07 80 2.82682483308656 2.82682483308656 1 16.2103568714924 80 671 361 493 1600 191 256 758 1247 1159 84 294 M16923 GO_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSSIFICATION.html Any process that modulates the frequency, rate or extent of bone formation. 113/250 Gene Ontology BP GO:0030278 7.57754063035665e-08 1.02572947949697e-06 510 515.454545454545 493 6.88867353759334e-09 45 1.78132134012387 1.82850622370502 1 12.6378223588972 507 45 277 93 70 698 775 1648 891 173 493 295 M12003 GO_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MOTILITY.html Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. 429/1223 Gene Ontology BP GO:0048870 6.33660308579993e-26 4.20297830390987e-23 335 510 494 5.76054825981811e-27 6 1.83061746195657 1.87535449165378 1 48.5251331662244 331 203 6 129 494 592 824 856 1493 17 665 296 M13227 GO_LOCALIZATION_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_OF_CELL.html Any process in which a cell is transported to, and/or maintained in, a specific location. 429/1223 Gene Ontology BP GO:0051674 6.33660308579993e-26 4.20297830390987e-23 335 529.090909090909 495 5.76054825981811e-27 7 1.83061746195657 1.87535449165378 1 48.5251331662244 332 204 7 130 495 593 825 1056 1494 18 666 297 M16725 GO_NEGATIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a lower concentration of a chemical. 30/67 Gene Ontology BP GO:0050919 1.65703548405509e-06 6.23469671999008e-06 90 625.363636363636 495 1.50639702921102e-07 38 1.87050219006188 2.00476189611045 1 11.5337995985011 90 906 699 495 2208 62 40 90 981 1270 38 298 M16429 GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. 72/262 Gene Ontology BP GO:0098742 1.68428864575881e-18 2.5226297362123e-16 1230 944.727272727273 496 1.53117149614437e-19 24 2.07812517091744 2.10979207976665 1 38.3992533645831 1227 61 30 242 450 1460 1203 3394 496 24 1805 299 M13078 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of multicellular organismal development. 850/2329 Gene Ontology BP GO:2000026 3.07134776851757e-14 1.76052687521322e-12 500 857.636363636364 497 3.0713477685176e-15 9 1.72812927176211 1.87681609023726 1 24.0631892830947 497 351 4007 25 421 522 971 433 1684 9 514 300 M13373 GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. 24/58 Gene Ontology BP GO:0030514 7.0567442965714e-07 3.50691032959052e-06 150 473.181818181818 497 6.41522414554683e-08 53 1.84142482009867 1.92693308294555 1 11.8996115839554 146 803 814 911 809 145 60 53 882 497 85 301 M16206 GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels. 458/1179 Gene Ontology BP GO:0072358 1.12782948026676e-25 5.81834697430951e-23 80 516.454545454545 499 1.02529952751523e-26 8 1.88233121891926 1.99352940714794 1 49.5809883501562 77 499 8 468 548 378 551 889 1647 41 575 302 M16442 GO_CIRCULATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. 458/1179 Gene Ontology BP GO:0072359 1.12782948026676e-25 5.81834697430951e-23 80 522.636363636364 500 1.02529952751523e-26 9 1.88233121891926 1.99352940714794 1 49.5809883501562 78 500 9 469 549 379 552 947 1648 42 576 303 M16623 GO_COPULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPULATION.html The act of sexual union between male and female, involving the transfer of sperm. 7/20 Gene Ontology BP GO:0007620 2.25051239264863e-05 4.92651062662309e-05 180 979.818181818182 500 2.25053518460062e-06 179 2.15579336633476 2.43579835739732 1 11.0003493502297 345 179 4594 1001 2141 358 180 284 500 583 613 304 M10678 GO_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 123/292 Gene Ontology BP GO:0002064 5.10979448691258e-14 2.79115009443942e-12 45 826.545454545455 502 4.64526771537518e-15 40 2.03974369724404 2.12942538923564 1 27.9186354512066 1140 40 79 41 42 1786 1438 2206 502 116 1702 305 M14034 GO_SYNAPTIC_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_SIGNALING.html Cell-cell signaling to or from a synapse. 168/577 Gene Ontology BP GO:0099536 2.97525363224901e-07 2.21840465441196e-06 505 684 502 2.70477639510802e-08 261 1.64383714684032 1.75929108142234 1 11.0100552485979 502 1232 425 740 433 266 637 1378 1279 261 371 306 M16017 GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/55 Gene Ontology BP GO:0032892 1.65444099649088e-06 6.22998341176575e-06 365 716.181818181818 502 1.50403840060241e-07 83 2.4242958409375 2.69852743813931 1 14.9495188037912 364 1258 828 823 1829 502 357 83 371 1043 420 307 M10869 GO_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WOUNDING.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. 333/807 Gene Ontology BP GO:0009611 2.19585382622396e-17 2.42746412265663e-15 260 530.636363636364 504 1.99623075111269e-18 41 1.97282921022401 2.08651113459458 1 34.1555944584342 256 504 41 150 1037 589 985 460 1115 88 612 308 M11315 GO_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGENERATION.html The regrowth of a lost or destroyed body part, such as an organ or tissue. 104/245 Gene Ontology BP GO:0031099 4.62394410770581e-06 1.31792341878932e-05 290 686.363636363636 506 4.20359438755158e-07 157 1.8523723169129 1.86455155442475 1 10.7086792633318 287 878 506 424 1532 384 722 842 1335 483 157 309 M11839 GO_AMEBOIDAL_TYPE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMEBOIDAL_TYPE_CELL_MIGRATION.html Cell migration that is accomplished by extension and retraction of a pseudopodium. 90/270 Gene Ontology BP GO:0001667 3.30775082126598e-08 5.70925169633382e-07 180 660.545454545455 508 3.00704624636253e-09 178 1.78681430993943 1.92382971355466 1 13.2153927936157 178 1069 226 701 508 282 347 791 2130 627 407 310 M15789 GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cell differentiation. 460/1237 Gene Ontology BP GO:0045597 6.01390663611323e-21 1.11690274045895e-18 510 507.454545454545 508 5.46718785101202e-22 10 1.81975861258191 1.98726536277886 1 38.6994091456415 510 361 24 243 209 826 1049 508 1254 10 588 311 M11371 GO_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). 238/666 Gene Ontology BP GO:0001501 7.50487074507623e-11 2.29923457862557e-09 275 597.545454545455 509 6.82260976848386e-12 138 1.83727210244387 1.88261193323561 1 18.8012054019229 275 509 138 485 885 444 878 700 1452 200 607 312 M16028 GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of embryonic development. 18/48 Gene Ontology BP GO:0040019 7.51190495185486e-07 3.64068629347204e-06 740 634.727272727273 510 6.82900683345247e-08 154 2.43273679205755 2.63508050302355 1 15.673919216811 738 1263 751 322 841 424 510 351 278 1350 154 313 M11553 GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 113/320 Gene Ontology BP GO:0071229 2.23872785441725e-11 7.75702494631289e-10 495 839.636363636364 511 2.03520714040003e-12 125 1.93226583531125 2.02236160855802 1 20.8534468558965 493 384 125 511 442 1454 1343 1329 1714 199 1242 314 M13649 GO_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REGENERATION.html The regrowth of lost or destroyed tissues. 31/80 Gene Ontology BP GO:0042246 1.94893732225587e-07 1.77429725239883e-06 655 729.727272727273 511 1.7717613590077e-08 176 2.00545059280787 1.88870483519811 1 13.6625382445765 652 429 765 176 297 511 658 2284 1327 496 432 315 M10583 GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 2/13 Gene Ontology BP GO:0010455 2.85668349831047e-06 9.13469799080958e-06 680 922.5 515.5 3.17409680585375e-07 50 1.6432603264234 -1.6432603264234 -1 9.80968611590865 680 187 3608 NA 1828 351 50 1117 338 1000 66 316 M11734 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 31/88 Gene Ontology BP GO:0001837 4.5782769121286e-07 2.78730492769333e-06 615 507.272727272727 516 4.16207078625846e-08 221 2.15422894891142 2.2385795868823 1 14.1755379141126 612 672 516 336 612 490 311 487 701 622 221 317 M12114 GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of epithelial cell proliferation. 173/422 Gene Ontology BP GO:0050678 6.31317110816409e-11 1.98054415237877e-09 435 508.272727272727 516 5.73924646213203e-12 65 1.81773796394388 2.12192247123987 1 18.7408410031194 433 516 137 65 934 613 842 208 1121 143 579 318 M13152 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 738/1994 Gene Ontology BP GO:0051240 1.65940840715221e-16 1.45370438385052e-14 390 864.454545454545 516 1.65940840715222e-17 6 1.76798837857688 1.94335434421034 1 28.9811667972713 388 353 4024 287 318 601 884 516 1606 6 526 319 M10094 GO_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. 57/154 Gene Ontology BP GO:0016358 3.12315182855733e-07 2.29236734544433e-06 520 615.727272727273 517 2.83922933811324e-08 81 1.56711387191058 1.75113961438942 1 10.4697377907494 517 81 719 506 449 441 423 623 1260 978 776 320 M10944 GO_PEPTIDE_CROSS_LINKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CROSS_LINKING.html The formation of a covalent cross-link between or within protein chains. 22/103 Gene Ontology BP GO:0018149 6.56354369463783e-08 9.31159914333526e-07 420 652.545454545455 517 5.96685808223319e-09 166 2.05701148855236 2.24465246658073 1 14.6961085074601 417 286 247 355 1369 874 679 1264 517 166 1004 321 M10764 GO_RESPONSE_TO_CORTICOSTEROID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTEROID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 107/288 Gene Ontology BP GO:0031960 2.3203293113241e-15 1.58430720477615e-13 65 606.181818181818 518 2.10939028302191e-16 43 2.11105749337362 2.26366248227405 1 32.010581150465 633 43 63 47 336 1587 1834 518 643 63 901 322 M12783 GO_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIOGENESIS.html The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. 101/263 Gene Ontology BP GO:0042063 5.37322993016761e-07 3.02032767140051e-06 485 678.818181818182 518 4.88475567501227e-08 235 2.048405472028 2.1790945071763 1 13.3945706966068 481 1235 413 235 696 860 1286 804 518 508 431 323 M10360 GO_BONE_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. 12/39 Gene Ontology BP GO:0061430 0.000241845735564042 0.00040640237069267 50 722.181818181818 519 2.19883932480953e-05 47 2.36574488329797 2.36574488329797 1 9.50340700714872 47 1011 519 775 2777 438 275 693 250 362 797 324 M10858 GO_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. 467/1187 Gene Ontology BP GO:0007010 1.54530528882137e-07 1.54964415896277e-06 785 666.636363636364 520 1.404823088514e-08 222 1.66572176076786 1.82882789439325 1 11.464082128655 784 953 431 520 222 404 800 441 1574 925 279 325 M12655 GO_BEHAVIORAL_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_PAIN.html Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 10/32 Gene Ontology BP GO:0048266 8.10036551767704e-07 3.80450762455325e-06 460 1016.27272727273 521 7.3639713638368e-08 57 2.17553162546628 2.17553162546628 1 13.9675045424684 457 1941 1347 1795 2735 455 316 57 521 1369 186 326 M12854 GO_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 43/117 Gene Ontology BP GO:0051963 8.1914428671147e-06 2.09547488881617e-05 600 582 524 7.44679397013981e-07 175 1.71064224726992 1.84035267784037 1 9.48121609564331 299 783 504 693 1698 274 175 524 596 259 597 327 M15024 GO_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOMINERAL_TISSUE_DEVELOPMENT.html Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. 39/111 Gene Ontology BP GO:0031214 2.04186861176118e-08 3.83821698963852e-07 765 475.818181818182 526 1.85624420973837e-09 96 2.10004221245179 2.09045139857787 1 15.9610577226562 176 96 218 634 762 492 627 526 762 155 786 328 M15014 GO_CONNECTIVE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNECTIVE_TISSUE_DEVELOPMENT.html The progression of a connective tissue over time, from its formation to the mature structure. 103/273 Gene Ontology BP GO:0061448 3.98506735565867e-09 9.20530732951403e-08 140 493.545454545455 527 3.62278851170655e-10 92 1.98365041242721 2.16642395235583 1 16.5335708809846 140 759 183 602 988 92 527 599 1079 216 244 329 M11868 GO_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH.html Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. 363/998 Gene Ontology BP GO:0040008 1.50162839155996e-08 2.91718017657443e-07 590 653.181818181818 528 1.36511672891768e-09 165 1.80844904968621 2.00749277479911 1 14.0001394365464 586 1526 212 528 423 344 1077 691 1431 202 165 330 M14752 GO_MULTICELLULAR_ORGANISMAL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_SIGNALING.html The transfer of information occurring at the level of a multicellular organism. 50/189 Gene Ontology BP GO:0035637 1.86418808241024e-06 6.75677226122619e-06 475 675.636363636364 530 1.69471787458837e-07 331 2.17239970393776 2.28194619498385 1 13.3054701611788 474 1160 350 413 1191 546 530 1199 435 331 803 331 M13048 GO_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEARNING.html Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. 65/227 Gene Ontology BP GO:0007612 6.01963708770282e-08 8.80184804655099e-07 385 551.545454545455 532 5.4723975021928e-09 52 1.51132564166855 1.62903656613825 1 10.8412858588012 384 768 1325 597 52 310 138 895 503 563 532 332 M11566 GO_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_MOVEMENT.html Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. 60/158 Gene Ontology BP GO:0030048 1.58227405887605e-09 3.97108024614136e-08 430 668 533 1.43843096364914e-10 171 2.46713498052476 2.80403426752771 1 21.6305091787398 427 533 171 741 182 847 719 1598 357 206 1567 333 M16150 GO_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION.html Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. 42/127 Gene Ontology BP GO:0061337 9.00037705977002e-07 4.10902169995204e-06 490 740.727272727273 534 8.18216431081711e-08 316 1.9995698099069 2.04306854921139 1 12.7585715957265 486 661 374 411 903 550 338 2755 534 316 820 334 M14073 GO_ACTIN_MEDIATED_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MEDIATED_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. 54/134 Gene Ontology BP GO:0070252 5.27733029397346e-11 1.70157253853603e-09 445 626 536 4.79757299463641e-12 133 2.46713498052476 2.80403426752771 1 25.6288110918511 444 536 133 669 200 784 598 1614 312 145 1451 335 M12865 GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 126/317 Gene Ontology BP GO:0090092 3.90243841055268e-07 2.57804519639595e-06 480 703.181818181818 537 3.54767191161935e-08 269 1.89459031681875 1.92306495749166 1 12.5431001624116 477 1734 373 269 537 617 998 873 1160 365 332 336 M13018 GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. 8/28 Gene Ontology BP GO:0045672 3.56469773387821e-07 2.49281718252034e-06 540 963.545454545455 540 3.56469830569648e-08 197 2.20517897777289 -2.20517897777289 -1 14.637486662448 536 1513 3993 1146 540 336 579 265 197 1054 440 337 M12811 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. 3/15 Gene Ontology BP GO:0048934 2.6076302226685e-06 8.56864229255907e-06 110 1124.27272727273 542 2.60763328255447e-07 107 2.88851526527842 2.88851526527842 1 17.3384860035333 469 1043 3963 1228 2593 461 542 109 432 1420 107 338 M14140 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 3/15 Gene Ontology BP GO:0048935 2.54264894885661e-06 8.44913067604104e-06 470 1145.27272727273 543 2.54265185813995e-07 103 2.88851526527842 2.88851526527842 1 17.3593588467368 470 1044 4191 1229 2594 462 543 103 433 1421 108 339 M10162 GO_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCRETION.html The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. 23/63 Gene Ontology BP GO:0007588 2.57823021343185e-10 7.34400176746263e-09 2750 1556.09090909091 544 2.3438456488491e-11 7 2.63679662127733 -2.22168670924632 -1 25.4075309875918 2746 121 151 7 923 3956 3455 4434 335 445 544 340 M16285 GO_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. 40/129 Gene Ontology BP GO:0001823 2.52426115171778e-07 2.03122088863529e-06 545 820.545454545455 544 2.29478312849944e-08 97 1.93648144744502 2.15676634897227 1 13.057944134342 1253 97 543 159 384 1285 983 2374 235 544 1169 341 M12726 GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 19/52 Gene Ontology BP GO:0051491 3.53763565584974e-06 1.07150184930832e-05 185 641.636363636364 545 3.21603758585274e-07 183 1.95517192208025 2.31090488631008 1 11.5111840272342 183 452 545 359 1435 446 197 674 1049 1038 680 342 M16055 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 23/54 Gene Ontology BP GO:0060999 1.60417965843633e-06 6.10008694031111e-06 145 848.545454545455 545 1.45834620741939e-07 80 2.07423138001557 2.07423138001557 1 12.8133170766582 141 1408 1760 1405 2014 207 95 80 545 1437 242 343 M10246 GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. 57/204 Gene Ontology BP GO:1900544 2.09151716764449e-08 3.86889012325632e-07 540 806.636363636364 546 1.90137926138939e-09 7 1.57126318952283 1.74164067783646 1 11.9357167409995 539 652 452 233 7 528 632 1044 3024 1216 546 344 M13998 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 57/204 Gene Ontology BP GO:0045981 2.09151716764449e-08 3.86889012325632e-07 540 804.181818181818 547 1.90137926138939e-09 8 1.57126318952283 1.74164067783646 1 11.9357167409995 540 653 453 234 8 529 633 1006 3025 1218 547 345 M16368 GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving mucopolysaccharide. 56/130 Gene Ontology BP GO:1903510 2.9104348385788e-06 9.27463895368661e-06 150 716 548 2.64585335352066e-07 148 1.92577272387603 1.97321806363455 1 11.4811230052573 148 1243 414 1348 1364 175 295 575 1429 548 337 346 M16413 GO_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized. 93/279 Gene Ontology BP GO:0048705 8.97807399496944e-09 1.85673702785213e-07 320 571 548 8.16188548328042e-10 196 1.86979896895835 1.97709345784751 1 14.9096917103596 318 640 201 529 502 548 669 768 1224 196 686 347 M11052 GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. 15/43 Gene Ontology BP GO:0045939 2.55037411930969e-07 2.04514456579532e-06 2850 1230 549 2.31852219542241e-08 21 2.76634464728484 -1.80932005424353 -1 18.6440968600215 2849 457 549 135 387 4254 3227 193 21 708 750 348 M11139 GO_SECOND_MESSENGER_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECOND_MESSENGER_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. 99/251 Gene Ontology BP GO:0019932 4.18604115257679e-09 9.57428033074584e-08 25 606.090909090909 551 3.80549196412889e-10 23 2.09309720870825 2.0557045756282 1 17.403481395593 23 879 185 680 1767 54 129 695 1557 551 147 349 M10442 GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS.html The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 22/50 Gene Ontology BP GO:0050951 6.47532598681817e-07 3.34426457806416e-06 505 578.909090909091 553 5.88666172065552e-08 217 2.25526283452535 2.24512699616225 1 14.6290057661467 503 808 567 507 772 503 217 1042 594 553 302 350 M10448 GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that stimulates, induces or increases the rate of macrophage activation. 7/16 Gene Ontology BP GO:0043032 9.06055609722542e-06 2.2753051624916e-05 325 1053.90909090909 555 9.06059303959197e-07 171 1.58210268366035 -1.77382673340849 -1 8.70177119283099 1010 944 3587 555 2640 324 321 200 171 1494 347 351 M15408 GO_OUTFLOW_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. 36/92 Gene Ontology BP GO:0003151 1.8034290389383e-06 6.5931661636146e-06 555 837.818181818182 555 1.63948228843979e-07 156 1.82168177078707 1.80969476233116 1 11.1803721502274 552 421 356 385 1177 795 981 1926 1912 156 555 352 M11136 GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of smooth muscle contraction. 34/84 Gene Ontology BP GO:0006940 7.63908551864e-07 3.66584713430389e-06 365 626.090909090909 556 6.94462561015437e-08 107 1.81002041908449 1.96026417364483 1 11.6553959520953 361 107 696 1037 850 321 457 556 1368 939 195 353 M12799 GO_NEPHRON_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. 44/140 Gene Ontology BP GO:0072009 5.21510082625231e-09 1.14756934295211e-07 1400 899.454545454545 556 4.74100076237699e-10 37 1.87093957743719 2.12067798263793 1 15.3819402560928 1400 90 192 37 92 2163 1733 2057 556 222 1352 354 M16126 GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. 33/105 Gene Ontology BP GO:2000177 2.15133021553521e-06 7.56714105358332e-06 570 580.727272727273 556 1.95575665388657e-07 120 2.11581687461219 2.30040753070022 1 12.8356148900093 570 556 906 120 1230 417 241 215 791 905 437 355 M12906 GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 26/75 Gene Ontology BP GO:0086065 4.93938629737266e-06 1.3882306645703e-05 345 704.090909090909 557 4.49036126108824e-07 228 1.90676191168475 1.72157221668665 1 10.9721249010775 343 566 657 356 1556 271 228 2236 557 575 400 356 M10532 GO_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASODILATION.html Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. 20/71 Gene Ontology BP GO:0042312 5.07154753872931e-07 2.91500405168887e-06 440 971.090909090909 558 4.61049882531601e-08 101 1.94626217620113 1.73444298496158 1 12.7621934628605 437 301 410 1391 662 306 101 3085 2815 616 558 357 M14991 GO_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 86/261 Gene Ontology BP GO:0050920 1.48266403557701e-07 1.52301086663364e-06 115 864.363636363636 558 1.34787648681765e-08 115 1.74001476730618 1.84057274865327 1 11.9909118914543 115 1885 265 1010 1484 381 576 558 2505 204 525 358 M13463 GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 9/39 Gene Ontology BP GO:0086012 1.96043239416844e-05 4.37189606442079e-05 355 1007.63636363636 560 1.96044968921145e-06 114 2.74592881062981 3.00035830260788 1 14.1803544724827 354 1117 4079 478 2277 560 258 275 114 772 800 359 M12831 GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL.html Any process that modulates the potential difference across a post-synaptic membrane. 18/76 Gene Ontology BP GO:0060078 9.33605371958221e-07 4.20847547767187e-06 550 683.454545454545 561 8.48732516499006e-08 257 1.54866612426065 1.6274341614642 1 9.86245431011001 547 454 1233 874 922 906 442 257 795 527 561 360 M16302 GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 79/167 Gene Ontology BP GO:0071260 4.05509421898058e-07 2.61980478260637e-06 335 735.454545454545 561 3.68644996947794e-08 177 1.71970016820733 1.84683317058284 1 11.3710267003737 333 1380 781 897 561 199 361 381 1681 1339 177 361 M12233 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 27/43 Gene Ontology BP GO:0010656 7.17371639643639e-07 3.53667743070534e-06 885 596.636363636364 562 6.52156248693517e-08 23 2.059069999732 2.11434571374738 1 13.2971194478127 885 562 439 504 817 664 521 646 1023 479 23 362 M15978 GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. 6/24 Gene Ontology BP GO:0010640 1.24746983593575e-05 2.98911833640521e-05 560 1056 563 1.24747683880554e-06 225 1.59968236360287 1.59968236360287 1 8.5738963277251 559 855 4490 395 1855 504 225 277 563 1315 578 363 M12465 GO_EAR_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_DEVELOPMENT.html The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 112/339 Gene Ontology BP GO:0043583 1.92099584739998e-11 6.70615317253992e-10 565 847.272727272727 565 1.74635986128796e-12 124 1.88345975972557 2.03763588249196 1 20.4677796681146 565 240 124 169 333 1561 1775 1900 1318 190 1145 364 M16576 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 100/279 Gene Ontology BP GO:0007178 1.34387971709217e-06 5.44314265028097e-06 360 701.818181818182 566 1.22170958000703e-07 219 2.08174689273374 2.35935303555373 1 12.9817801437605 356 1834 459 841 1053 429 712 219 774 566 477 365 M11359 GO_ARTERY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_DEVELOPMENT.html The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. 56/156 Gene Ontology BP GO:0060840 2.55881152771042e-08 4.56944689352288e-07 135 474.090909090909 569 2.32619232497442e-09 131 1.99842931921575 2.07493691339137 1 15.0094730231865 131 261 220 278 1026 569 652 587 639 164 688 366 M15882 GO_NOTOCHORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTOCHORD_DEVELOPMENT.html The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. 24/52 Gene Ontology BP GO:0030903 1.87332204413655e-05 4.21406698203779e-05 460 706.636363636364 569 1.7030345416833e-06 189 2.27301386407578 2.4051873439135 1 11.7811536065417 459 569 560 189 1947 946 992 707 265 370 769 367 M11483 GO_CHONDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. 19/43 Gene Ontology BP GO:0002063 2.65378515980546e-06 8.67102357281965e-06 195 652.272727272727 570 2.41253487361966e-07 54 2.15173450583628 2.30295208769161 1 12.9027663554626 194 1635 584 844 2075 73 209 312 625 570 54 368 M14605 GO_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/46 Gene Ontology BP GO:0051955 3.02679709326142e-06 9.54581402769266e-06 710 628.272727272727 570 2.7516375068981e-07 139 2.65131611538445 2.838395411895 1 15.7673774557858 709 572 570 354 1381 978 500 232 139 413 1063 369 M13650 GO_MESODERM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_MORPHOGENESIS.html The process in which the anatomical structures of the mesoderm are generated and organized. 49/111 Gene Ontology BP GO:0048332 4.11963952615208e-07 2.61980478260637e-06 250 743.636363636364 571 3.74512754325538e-08 138 1.75664086567356 1.83576671341795 1 11.6152865586379 138 1161 1304 564 571 248 249 812 733 1996 404 370 M14191 GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 103/238 Gene Ontology BP GO:0031345 4.74378379981314e-07 2.83102675868026e-06 485 687.545454545455 571 4.31253165699919e-08 449 1.73527731222175 1.97293033872214 1 11.4048023802692 449 758 494 483 632 571 755 497 1745 698 481 371 M12492 GO_ARTERY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_MORPHOGENESIS.html The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. 41/97 Gene Ontology BP GO:0048844 5.75185464049131e-09 1.25379629557752e-07 575 522.545454545455 572 5.228958777754e-10 111 1.97214555518351 2.05989491869336 1 16.1241820826176 231 784 193 224 929 612 1008 572 573 111 511 372 M11704 GO_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 43/108 Gene Ontology BP GO:0045446 1.66069978696836e-08 3.18621037640251e-07 225 569 575 1.50972709045852e-09 76 2.1002299556518 2.07869414275271 1 16.1636495524575 225 976 215 575 1279 154 184 639 1170 766 76 373 M11375 GO_CARDIAC_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MYOFIBRIL_ASSEMBLY.html The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. 15/41 Gene Ontology BP GO:0055003 1.10427829224463e-06 4.71246701368732e-06 290 583.454545454545 576 1.0038898604833e-07 144 3.05689191263085 3.20670743829522 1 19.2894834552556 288 586 380 272 983 576 749 641 144 537 1262 374 M14574 GO_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT.html The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 87/290 Gene Ontology BP GO:0045165 1.07934244436065e-08 2.18837858915568e-07 1035 1027.54545454545 576 9.81220408778198e-10 58 2.24334023168241 2.60348287820445 1 17.6986218064851 1033 58 206 74 576 2967 2965 1151 546 356 1371 375 M13507 GO_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASODILATION.html An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. 18/34 Gene Ontology BP GO:0042311 4.4423928847068e-08 6.94479130090696e-07 155 451.272727272727 577 4.03853906764608e-09 2 2.38746612782298 2.38746612782298 1 17.4172264132385 152 305 649 577 769 61 70 662 764 953 2 376 M13732 GO_CELLULAR_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 16/40 Gene Ontology BP GO:0071361 1.92403413931358e-07 1.75506689760962e-06 580 647.363636363636 578 1.74912209780192e-08 203 2.17291790957783 2.22317895050687 1 14.815625734577 578 315 476 215 295 1075 1141 203 1303 809 711 377 M16425 GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. 59/153 Gene Ontology BP GO:0001936 1.02420822315816e-06 4.49016415778085e-06 440 688.818181818182 578 9.31098818161621e-08 310 2.01224912087431 2.0342047222331 1 12.7476430676804 440 650 310 715 1197 482 578 782 1526 354 543 378 M14286 GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE.html Any process in by an organism or tissue maintains a population of neuronal stem cells. 18/36 Gene Ontology BP GO:0097150 8.04219303438633e-07 3.79688087709529e-06 3935 1691.81818181818 581 7.31108724931411e-08 48 2.33554101927081 -1.76347449696177 -1 14.9972196420142 3933 573 581 205 864 4142 4581 291 48 528 2864 379 M10724 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 21/68 Gene Ontology BP GO:0051966 1.19431328133589e-06 4.98668755867136e-06 715 704.818181818182 582 1.08573993608441e-07 292 2.03315728441185 2.2905687703936 1 12.7703891250567 712 292 582 535 1014 1399 1082 320 300 509 1008 380 M15914 GO_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. 269/738 Gene Ontology BP GO:0030855 1.16471863658505e-24 4.50649052472033e-22 585 434 583 1.05883512416823e-25 12 2.11636892851058 2.2490243690906 1 53.516691469834 583 365 12 19 104 605 1063 616 638 38 731 381 M11800 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 664/1619 Gene Ontology BP GO:0051130 1.424085280801e-07 1.48251747954238e-06 900 1015.36363636364 587 1.42408537206185e-08 226 1.68653853737647 1.88966071822688 1 11.6457745065085 899 496 3807 432 226 1051 1266 394 1623 388 587 382 M15282 GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle development. 68/167 Gene Ontology BP GO:0048634 2.08139259919151e-07 1.85132295748011e-06 590 782.363636363636 587 1.89217526919045e-08 34 1.89997376197002 2.26397166807752 1 12.9024166299526 587 1536 969 848 315 457 538 135 1619 1568 34 383 M15288 GO_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_BEHAVIOR.html The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. 87/330 Gene Ontology BP GO:0007626 8.90032026751624e-08 1.14815172256589e-06 590 653.818181818182 588 8.09120057053423e-09 60 1.80872652819928 2.00720512718902 1 12.7273342571973 588 60 534 373 98 735 817 944 1786 491 766 384 M16435 GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity. 15/40 Gene Ontology BP GO:0035587 5.55408863726137e-08 8.29891725982205e-07 50 596.818181818182 588 5.04917161589008e-09 44 1.97312071261451 1.97312071261451 1 14.2136356435925 165 700 884 951 44 50 47 588 2034 1024 78 385 M11036 GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 36/90 Gene Ontology BP GO:0051965 6.00744104900076e-06 1.62733656887459e-05 210 579 589 5.46132495755686e-07 100 1.65752685155188 1.78267042391875 1 9.40243066430998 208 667 677 869 1605 225 100 370 641 418 589 386 M12903 GO_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 221/509 Gene Ontology BP GO:0070482 4.46033141981634e-08 6.94509338929884e-07 600 724.090909090909 597 4.05484682749649e-09 236 1.73335346937271 1.8624283207324 1 12.645254217258 597 371 236 277 467 778 1308 1126 1673 505 627 387 M13804 GO_EPIBOLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIBOLY.html The expansion of one cell sheet over other cells or yolk. 23/53 Gene Ontology BP GO:0090504 4.40401956555792e-07 2.73367150305955e-06 810 846.545454545455 597 4.00365495196975e-08 126 2.48395449387965 2.27074583934761 1 16.3700707268691 807 126 308 382 597 1266 1902 2203 356 340 1025 388 M15722 GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. 120/298 Gene Ontology BP GO:0090257 1.00392991527747e-07 1.23313402027336e-06 385 825.090909090909 599 9.12663600990902e-09 117 1.67524316775044 1.81794200174111 1 11.7265194775286 383 1530 599 1091 117 198 397 1070 2208 1177 306 389 M15855 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. 35/82 Gene Ontology BP GO:0032233 6.02554266299299e-07 3.23212152206309e-06 830 616 599 5.47776755756299e-08 240 1.85526840112607 1.82406048990947 1 12.0669540556382 830 552 790 316 736 481 240 1106 334 792 599 390 M10883 GO_ASSOCIATIVE_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASSOCIATIVE_LEARNING.html Learning by associating a stimulus (the cause) with a particular outcome (the effect). 33/113 Gene Ontology BP GO:0008306 1.45500665967604e-07 1.50458706478304e-06 555 741.454545454545 601 1.32273341445939e-08 156 1.46707578679774 1.34046545739457 1 10.1192014726394 664 553 1887 553 203 355 156 967 601 1465 752 391 M11608 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. 17/45 Gene Ontology BP GO:0060043 7.0625494476579e-07 3.50691032959052e-06 470 633.272727272727 601 6.42050155901244e-08 115 3.11402458111171 3.47839964419695 1 20.1233765906924 468 829 601 115 810 873 743 567 285 1233 442 392 M15681 GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. 40/181 Gene Ontology BP GO:0007156 1.12158475858678e-08 2.24461984229242e-07 615 617.181818181818 601 1.01962251300431e-09 16 2.2221658516519 2.46180762723452 1 17.5025583860202 614 660 209 16 499 740 1001 1768 412 269 601 393 M16895 GO_RECEPTOR_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CLUSTERING.html The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. 23/64 Gene Ontology BP GO:0043113 2.01415314281073e-06 7.18257530112921e-06 605 712.272727272727 602 1.83104998801723e-07 97 1.47202403406117 1.87642384420847 1 8.96954111332436 602 802 880 360 1212 717 547 97 269 1903 446 394 M11423 GO_REGULATION_OF_DOPAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of dopamine. 5/27 Gene Ontology BP GO:0014059 2.26851834406739e-06 7.80780627984053e-06 325 997.090909090909 604 2.26852065984968e-07 100 3.21226081045252 3.21226081045252 1 19.4354575982614 325 1522 3743 1120 1735 400 186 100 146 1087 604 395 M11646 GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM.html The process in which the anatomical structures of embryonic epithelia are generated and organized. 86/203 Gene Ontology BP GO:0016331 9.64584891138235e-08 1.20322857466072e-06 1360 1150.36363636364 604 8.76895394027489e-09 112 1.68174877929145 1.8091070754351 1 11.7932994827532 1357 249 604 309 112 2533 1971 2300 555 559 2105 396 M14273 GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 126/288 Gene Ontology BP GO:0010810 4.5882591026154e-10 1.25313453020255e-08 605 578.454545454545 604 4.17114463961119e-11 158 1.76520147950687 1.92456216229455 1 16.5237833507657 197 234 158 628 604 674 603 810 1446 178 831 397 M13455 GO_SPINAL_CORD_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_PATTERNING.html The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. 7/34 Gene Ontology BP GO:0021511 1.11442955599632e-06 4.74706094356963e-06 960 920.545454545455 605 1.11443011487567e-07 52 1.98201751034001 1.84370797555081 1 12.4993929910366 959 176 4077 588 1023 624 314 207 52 1501 605 398 M13499 GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 10/37 Gene Ontology BP GO:0061037 9.4356629664229e-07 4.2305182501105e-06 370 796.727272727273 606 8.57787910302036e-08 24 1.98341131643002 1.98341131643002 1 12.6257354534908 369 1863 1275 606 1169 128 69 1561 329 1371 24 399 M15663 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. 34/90 Gene Ontology BP GO:1901379 4.50765875689046e-07 2.76473706846003e-06 250 846.909090909091 606 4.09787243680097e-08 88 1.55648072943847 1.6218207613606 1 10.2486666858298 250 987 849 819 606 96 88 2903 1944 469 305 400 M10367 GO_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_SECRETION.html The controlled release of acid by a cell or a tissue. 28/113 Gene Ontology BP GO:0046717 5.98129925871045e-06 1.62120096078182e-05 570 803.636363636364 607 5.43755956414875e-07 347 2.40535564571241 2.6467636944275 1 13.6492142788262 568 1170 398 534 1604 1106 782 347 607 516 1208 401 M13010 GO_LEUKOCYTE_TETHERING_OR_ROLLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_TETHERING_OR_ROLLING.html Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). 10/17 Gene Ontology BP GO:0050901 2.92050358839787e-06 9.29396721105642e-06 1140 710.272727272727 607 2.65500678670759e-07 66 2.16484622456497 2.59211696388914 1 12.9041193258085 1137 159 441 66 1366 863 301 1434 937 607 502 402 M13039 GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. 57/171 Gene Ontology BP GO:0071774 4.3360610224944e-07 2.70268065982377e-06 425 1056.18181818182 608 3.9418744337317e-08 360 1.89834276496142 2.12358756524843 1 12.5218331166853 421 2888 987 2089 590 556 608 360 1515 1217 387 403 M14170 GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL.html The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. 10/17 Gene Ontology BP GO:0061756 2.92050358839787e-06 9.29396721105642e-06 1140 713.363636363636 608 2.65500678670759e-07 67 2.16484622456497 2.59211696388914 1 12.9041193258085 1138 160 442 67 1367 864 302 1458 938 608 503 404 M12172 GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. 40/92 Gene Ontology BP GO:0001954 1.99584343968057e-07 1.79935943503629e-06 400 582.090909090909 611 1.81440329158529e-08 214 2.10470781979248 2.22998594097708 1 14.3235603964308 397 663 270 284 1019 611 333 686 1032 214 894 405 M12549 GO_PROTEIN_HETEROTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTRIMERIZATION.html The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. 16/31 Gene Ontology BP GO:0070208 1.92473619127076e-05 4.30677114991332e-05 215 741.090909090909 615 1.74977548237334e-06 212 2.36953879328458 2.46002675872416 1 12.2549204657722 212 923 760 1181 1956 440 615 826 251 416 572 406 M15366 GO_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. 76/209 Gene Ontology BP GO:0010001 1.63904103891564e-07 1.61692190219132e-06 835 786.181818181818 615 1.49003741911569e-08 117 2.13812274363035 2.31345301516274 1 14.6685629671757 832 964 568 117 233 1628 1964 593 431 703 615 407 M16627 GO_NEPHRIC_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_MORPHOGENESIS.html The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. 14/25 Gene Ontology BP GO:0072178 5.38481740199866e-07 3.02318103959852e-06 145 472.636363636364 616 4.89528974546441e-08 29 1.73874025081302 1.8642748776403 1 11.3688177210526 143 837 1093 616 697 146 29 172 622 656 188 408 M16687 GO_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a cell of a different type via adhesion molecules. 15/46 Gene Ontology BP GO:0034113 3.04748301817515e-07 2.2530993078642e-06 620 856.909090909091 616 2.77043949119867e-08 262 1.96707261327354 1.8881494741506 1 13.1593100437037 616 927 1031 262 440 545 409 3068 441 1025 662 409 M12651 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate, or extent of leukocyte migration. 55/148 Gene Ontology BP GO:0002687 1.57529994156717e-08 3.04754901195681e-07 375 808.363636363636 617 1.43209086622457e-09 188 1.77728687005832 1.83227970609642 1 13.7189205972462 374 892 213 1389 998 406 516 617 2650 188 649 410 M15496 GO_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION.html The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. 21/98 Gene Ontology BP GO:0001708 2.74362616976027e-07 2.13021008464831e-06 310 755.727272727273 617 2.4942059199261e-08 226 2.94303639260197 3.21818424708805 1 19.7732279488925 307 2149 617 1059 406 476 349 806 694 1224 226 411 M10808 GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. 55/184 Gene Ontology BP GO:0048706 6.89381272886472e-08 9.64095557232497e-07 485 818.727272727273 619 6.26710267716899e-09 249 1.97147305875855 2.15523089169971 1 14.0497324843338 482 259 249 339 619 1415 1294 1308 1194 349 1498 412 M13126 GO_NEURON_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. 7/44 Gene Ontology BP GO:0048665 6.98242412339526e-08 9.70640574997731e-07 330 809.454545454545 619 6.98242434278939e-09 14 2.83769290223522 2.83769290223522 1 20.2129844666405 326 718 4017 704 1030 373 619 14 108 920 75 413 M10516 GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. 28/70 Gene Ontology BP GO:0055024 5.88276259530621e-06 1.60009764089085e-05 265 906.363636363636 620 5.3479802961566e-07 262 2.73046273986223 2.93593609331605 1 15.512443709709 262 2659 863 620 1601 499 320 515 730 1458 443 414 M13473 GO_FACE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FACE_DEVELOPMENT.html The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. 36/90 Gene Ontology BP GO:0060324 8.77487287503866e-07 4.02984517891241e-06 420 751.909090909091 620 7.97716034087963e-08 419 1.79989574949153 1.87960681213113 1 11.5025366309444 526 419 593 556 896 836 1366 1279 761 419 620 415 M16856 GO_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 13/37 Gene Ontology BP GO:0010453 9.62255650542432e-08 1.20322857466072e-06 860 731.363636363636 620 8.74777902391303e-09 16 1.61609032251549 1.74458599677572 1 11.3328680768921 857 319 720 632 1500 620 403 16 2052 604 322 416 M11149 GO_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that modulates the frequency or rate of macrophage activation. 11/34 Gene Ontology BP GO:0043030 8.12906092004125e-06 2.08410987585596e-05 560 842.818181818182 621 7.39008268845621e-07 22 1.4423675809616 -1.52945499027073 -1 7.99834198706517 558 1282 1841 805 2542 105 22 384 621 983 128 417 M13484 GO_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 212/583 Gene Ontology BP GO:0052547 7.22184463728258e-07 3.54825657681513e-06 600 774 622 6.56531546178847e-08 225 1.84209198636816 1.98938090711334 1 11.8928148889056 786 1369 302 600 822 622 1401 598 1405 225 384 418 M15529 GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 20/44 Gene Ontology BP GO:0002089 3.21801550688132e-07 2.33456968725781e-06 625 715 622 2.92546907053782e-08 303 1.68175267483265 1.7492519870332 1 11.2198450578022 622 303 1345 458 461 614 512 1243 656 834 817 419 M15511 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT.html Any process that modulates the frequency, rate or extent of the movement of a cellular component. 450/1139 Gene Ontology BP GO:0051270 4.37824862459663e-24 1.45201488314301e-21 250 659.454545454545 623 3.98022602236057e-25 13 1.78017293059489 1.87813975474244 1 43.9437296913071 248 623 13 517 901 549 788 922 1823 31 839 420 M15768 GO_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. 31/92 Gene Ontology BP GO:0048709 3.55661106112288e-08 5.94005221467394e-07 770 637.909090909091 623 3.23328283510958e-09 20 2.30587328797609 2.51442088820516 1 17.0073732646474 769 558 651 326 20 1392 1454 683 124 623 417 421 M12068 GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. 6/17 Gene Ontology BP GO:0032460 6.70708819752172e-07 3.41822101784941e-06 825 943.181818181818 624 6.70709022184901e-08 267 2.04269391522445 -2.47204549572382 -1 13.2271673525681 822 485 3846 954 830 397 557 293 267 1300 624 422 M12414 GO_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/110 Gene Ontology BP GO:0051952 1.59094318621238e-06 6.08463691399017e-06 625 765.363636363636 624 1.44631303337604e-07 106 2.3773253198966 2.73544247719569 1 14.6887456678512 624 106 454 853 1117 1397 1003 594 310 431 1530 423 M16939 GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of cell proliferation. 406/1017 Gene Ontology BP GO:0008285 6.04394429868359e-11 1.9220570807389e-09 475 628.636363636364 624 5.49449481713603e-12 135 1.7339814018827 1.95424449672213 1 17.9040533352746 472 624 135 253 664 761 1094 679 1562 141 530 424 M14175 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. 32/51 Gene Ontology BP GO:0014911 4.14706131917492e-06 1.21404827899932e-05 45 896.636363636364 625 3.77006285138339e-07 43 1.9969162689055 2.10469183585958 1 11.6286399124389 43 1790 625 918 2353 123 178 133 1656 1833 211 425 M14420 GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION.html A cardiac conduction process that modulates the frequency or rate of heart contraction. 22/62 Gene Ontology BP GO:0086091 5.57909226554069e-06 1.53004875303635e-05 370 727.818181818182 627 5.07191492172335e-07 210 2.10905047009637 2.09365663246619 1 12.0306166332032 370 997 627 487 1593 335 210 1236 775 557 819 426 M12990 GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 136/352 Gene Ontology BP GO:0070372 1.55280139448407e-07 1.55380536090292e-06 365 899.727272727273 629 1.4116377309852e-08 223 1.59456309052785 1.60194212538266 1 10.9721431705171 363 1675 573 1504 223 352 599 692 2561 629 726 427 M11649 GO_TONGUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TONGUE_DEVELOPMENT.html The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. 4/29 Gene Ontology BP GO:0043586 2.14047248561363e-05 4.7167982849085e-05 635 1148.63636363636 631 2.14049310319421e-06 36 3.88207138505673 3.88207138505673 1 19.8958960620433 631 2380 3782 829 2284 312 48 455 36 1697 181 428 M11927 GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY.html Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 120/367 Gene Ontology BP GO:0050803 3.93144575232425e-07 2.58975027627706e-06 615 761.454545454545 633 3.57404223171087e-08 394 1.65524560936507 1.7827180241333 1 10.9546650733004 615 1314 633 706 541 561 575 908 1233 394 896 429 M15636 GO_CELLULAR_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 29/58 Gene Ontology BP GO:0071295 1.24117943536603e-07 1.37865935846998e-06 320 679.181818181818 633 1.12834500489997e-08 243 2.32368779214916 2.30296304004833 1 16.1322034907232 320 280 260 557 1011 633 1428 982 1055 243 702 430 M13433 GO_MESONEPHRIC_TUBULE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHRIC_TUBULE_MORPHOGENESIS.html The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. 24/83 Gene Ontology BP GO:0072171 4.21007526232372e-07 2.6545881776399e-06 2670 1543.18181818182 634 3.82734187999423e-08 71 1.82811961211222 -1.48341559461168 -1 12.0755142729354 2666 122 618 71 581 3446 3040 3469 217 634 2111 431 M16887 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. 152/394 Gene Ontology BP GO:0032102 9.92212896485731e-08 1.22522459531469e-06 515 859.363636363636 634 9.02011764759198e-09 212 1.69431573293571 1.92934784064931 1 11.8656344050651 514 634 254 415 212 1124 848 1751 1966 281 1454 432 M11618 GO_CRANIAL_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 25/92 Gene Ontology BP GO:0021545 6.7529626459917e-06 1.78451938334317e-05 265 691.454545454545 636 6.13907579499265e-07 141 2.38649341310112 2.60684190558108 1 13.4243350929936 263 806 901 937 1652 251 243 171 636 1605 141 433 M12230 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WOUND_HEALING.html Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 31/82 Gene Ontology BP GO:0061045 5.22339795209707e-10 1.41001376113876e-08 565 817.545454545455 639 4.74854359394295e-11 128 2.13395056282276 2.11862649888004 1 19.8460938530582 563 557 159 293 1567 786 639 2327 1010 128 964 434 M13821 GO_DISTAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISTAL_TUBULE_DEVELOPMENT.html The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. 6/19 Gene Ontology BP GO:0072017 6.41392778248417e-08 9.22515255323401e-07 1425 1423.90909090909 642 6.41392796760727e-09 25 1.77099715855018 2.17592998929984 1 12.6612063160278 1423 1298 4138 642 63 3167 3897 25 210 460 340 435 M11508 GO_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_CYCLE.html Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 10/27 Gene Ontology BP GO:0042634 3.10285113687341e-06 9.72757449595088e-06 1215 694.272727272727 643 2.82077773918417e-07 75 3.0063139603764 3.4320743413189 1 17.8493769423389 1213 935 643 305 1387 945 438 726 75 606 364 436 M15116 GO_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 44/111 Gene Ontology BP GO:0034332 1.19441217627001e-07 1.35569481751838e-06 645 630.272727272727 644 1.08582931010582e-08 59 2.05557864587336 2.17459707907818 1 14.288619391228 644 93 488 59 147 1163 1234 1027 477 821 780 437 M13212 GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. 9/26 Gene Ontology BP GO:0030859 7.77338329066925e-09 1.64053720993533e-07 880 889.636363636364 645 7.77338331786071e-10 2 2.68363331460474 2.97063720674519 1 21.5700913827113 880 329 4033 94 2 936 1237 645 26 1201 403 438 M16968 GO_HEAD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_MORPHOGENESIS.html The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. 28/69 Gene Ontology BP GO:0060323 1.93101019444872e-06 6.96093193542345e-06 195 571.090909090909 645 1.75546535396369e-07 195 1.79128698599014 2.04293553049275 1 10.9438050226876 195 428 666 721 1198 263 664 325 809 645 368 439 M10898 GO_OTIC_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OTIC_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. 15/42 Gene Ontology BP GO:0071599 1.48800703370431e-06 5.82853325845031e-06 370 763.545454545455 646 1.35273458194897e-07 186 2.19619483230001 2.40544784408278 1 13.6181840446343 368 581 322 186 2326 770 646 840 800 374 1186 440 M10709 GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 128/326 Gene Ontology BP GO:0060828 7.40007199953455e-05 0.000138486635605961 400 856.818181818182 647 6.72756447744674e-06 319 2.08736387954945 2.14543712537566 1 9.54124535396603 398 1783 600 512 2450 656 697 459 904 647 319 441 M14313 GO_ACIDIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSPORT.html The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/26 Gene Ontology BP GO:0015800 3.5460772154847e-06 1.07330094599058e-05 650 1391 647 3.54608287409604e-07 128 2.20704106692212 2.20704106692212 1 12.9921730283197 647 1948 4223 1866 3013 634 360 128 467 1503 512 442 M14200 GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS.html A multicellular organism process which involves another multicellular organism of the same or different species. 112/337 Gene Ontology BP GO:0044706 1.15556739104345e-16 1.03178834550284e-14 650 891.272727272727 649 1.0505158100395e-17 49 2.19518237903761 2.19111744998875 1 36.3709734921644 649 238 49 146 405 1575 1897 2587 1081 119 1058 443 M13687 GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 265/679 Gene Ontology BP GO:0009991 2.51919998020073e-12 9.86202770796254e-11 890 728.090909090909 650 2.29018180018511e-13 109 1.93167790117443 2.21603489904166 1 22.8967976433919 888 743 109 643 474 908 1825 650 1168 342 259 444 M12853 GO_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_GROWTH.html Any process that modulates the frequency, rate or extent of growth of an organ of an organism. 40/110 Gene Ontology BP GO:0046620 5.80727061460671e-07 3.17155937022467e-06 685 650.272727272727 652 5.27933831594017e-08 118 2.7426704020236 3.06780423454048 1 17.8654455317893 684 1321 613 118 721 1036 562 132 287 1027 652 445 M14602 GO_DETECTION_OF_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_STIMULUS.html The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. 150/1291 Gene Ontology BP GO:0051606 6.70017883956944e-07 3.41822101784941e-06 655 927.727272727273 654 6.09107352739435e-08 142 1.91012802947619 2.05951940198569 1 12.3687561310407 654 2489 368 1535 785 452 1133 596 1622 429 142 446 M10248 GO_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION.html The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 213/1652 Gene Ontology BP GO:0007600 4.22617141250996e-16 3.38312308073858e-14 560 658.272727272727 656 3.84197401137269e-17 54 1.9887615769173 2.15176791826675 1 31.7358686410315 560 221 54 850 689 819 1511 561 1205 115 656 447 M11039 GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of vasculature development. 88/200 Gene Ontology BP GO:1904018 2.37974169769964e-07 1.97659046554909e-06 320 839.181818181818 657 2.16340177737865e-08 278 1.8944560261707 1.89796931375588 1 12.8011336838193 316 1237 278 1262 361 565 776 841 2426 512 657 448 M10703 GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS.html The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 73/306 Gene Ontology BP GO:0050954 2.27896121319474e-09 5.56906153308588e-08 940 850.818181818182 658 2.07178292323227e-10 73 2.48012313958851 2.69223331234335 1 21.3128688934993 937 73 176 488 1195 1373 2339 1024 658 457 639 449 M12350 GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. 17/72 Gene Ontology BP GO:0001754 2.3453885658013e-07 1.96311268848144e-06 2100 1507.72727272727 658 2.13217165076352e-08 144 1.83063084505403 1.79243648249902 1 12.3763008754179 2098 144 658 596 354 3199 3012 3550 631 339 2004 450 M12511 GO_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 47/116 Gene Ontology BP GO:0006029 2.36120242646303e-06 7.97893949495477e-06 60 623.818181818182 658 2.14654996425783e-07 32 2.0367336752115 2.01597041208353 1 12.3003307116198 56 658 492 1276 1283 78 32 929 1072 752 234 451 M11316 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. 9/16 Gene Ontology BP GO:0055022 6.57282052029282e-05 0.000124510835070255 660 1237.72727272727 659 6.57301493724919e-06 106 3.41504248625407 3.41504248625407 1 15.7969108198379 659 2327 3729 237 2797 743 297 496 106 1908 316 452 M12408 GO_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_DEVELOPMENT.html The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. 97/277 Gene Ontology BP GO:0060348 1.84358613729997e-06 6.69803448568157e-06 460 712.636363636364 660 1.67598880201396e-07 326 1.75270172236904 1.75323227166528 1 10.7427851052315 456 526 389 652 1185 660 1150 661 1042 326 792 453 M16216 GO_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_MIGRATION.html The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. 8/26 Gene Ontology BP GO:0014812 2.42899089355314e-07 1.99607163164022e-06 285 1102.09090909091 660 2.42899115905303e-08 30 1.67457586374196 1.67457586374196 1 11.3069195124771 283 1870 4528 660 1434 132 33 30 1320 1763 70 454 M16411 GO_NEGATIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_GROWTH.html Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 9/16 Gene Ontology BP GO:0061117 6.57282052029282e-05 0.000124510835070255 660 1317.45454545455 660 6.57301493724919e-06 107 3.41504248625407 3.41504248625407 1 15.7969108198379 660 2328 4560 238 2798 744 298 507 107 1935 317 455 M13079 GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 41/98 Gene Ontology BP GO:0060998 1.51890323958729e-06 5.92129953098553e-06 60 635.363636363636 663 1.38082208023195e-07 8 1.95224557984244 1.95626332486875 1 12.0896415327948 58 1474 1169 1102 1552 68 8 73 663 687 135 456 M13197 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 37/84 Gene Ontology BP GO:2001239 3.55336792356143e-06 1.0748069882147e-05 160 663 667 3.23033969350714e-07 74 1.98838960900521 2.012084184649 1 11.7036044562505 158 1086 794 667 2512 104 110 120 784 884 74 457 M16074 GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. 103/259 Gene Ontology BP GO:0030178 7.73832614770617e-06 1.99808790367567e-05 655 1047.18181818182 668 7.03486669708265e-07 179 2.10317987122814 2.18840988698343 1 11.7083452463952 653 2424 962 656 2665 1104 654 179 668 1106 448 458 M11957 GO_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING.html The series of events that restore integrity to a damaged tissue, following an injury. 278/666 Gene Ontology BP GO:0042060 4.11051068677365e-13 1.81762867797048e-11 300 712.272727272727 669 3.73682789706766e-14 97 1.9165845799665 2.01521693315654 1 24.3854262837493 300 1306 97 576 1116 669 1018 545 1259 159 790 459 M12594 GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 94/241 Gene Ontology BP GO:0071453 1.36636003912281e-07 1.45171845804284e-06 495 1035.45454545455 669 1.24214556725792e-08 187 1.43668784548565 1.56499410361184 1 9.93603893843581 492 1676 1235 1468 187 348 387 669 2280 2368 280 460 M16538 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. 43/230 Gene Ontology BP GO:0007187 1.64728122880017e-07 1.61692190219132e-06 220 882.454545454545 669 1.49752850194791e-08 199 1.83288926468496 1.81035544570756 1 12.5745124584944 219 1162 669 1569 237 328 283 865 2624 1552 199 461 M15388 GO_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_SECRETION.html Any process that modulates the frequency, rate, or extent of peptide secretion. 126/327 Gene Ontology BP GO:0002791 1.02297204509403e-05 2.52507134788494e-05 480 1031.72727272727 673 9.29978910740924e-07 277 1.57076747331771 1.65622282426781 1 8.55525649361912 476 1605 673 1289 1761 277 419 1339 2228 621 661 462 M12357 GO_DETECTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS.html The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. 20/46 Gene Ontology BP GO:0016048 2.32144190075718e-06 7.89630384264878e-06 570 769.909090909091 674 2.11040395486209e-07 235 2.15515429091772 2.11496803461485 1 13.027044830662 566 1256 674 730 1275 484 235 1478 752 617 402 463 M15877 GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the inflammatory response. 57/167 Gene Ontology BP GO:0050729 1.97369617265579e-07 1.7828543442881e-06 475 1806.72727272727 675 1.79426940883903e-08 85 1.9270153559234 1.85918814887225 1 13.1234124224982 2435 85 471 579 302 4102 3395 4011 675 471 3348 464 M10805 GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION.html Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 13/28 Gene Ontology BP GO:0010544 1.41707165922127e-07 1.47853117163244e-06 280 815.272727272727 678 1.28824704590745e-08 264 2.36420427149507 2.34834395439097 1 16.3284227844107 277 836 264 908 2077 588 678 1459 947 289 645 465 M15295 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION.html The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. 26/73 Gene Ontology BP GO:0006929 4.43302476992893e-06 1.27209728101236e-05 465 1018 679 4.03003063868086e-07 198 2.43970348884262 2.61384133767095 1 14.1484983716717 461 3208 1054 1379 1521 307 284 385 679 1722 198 466 M16970 GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of stem cell differentiation. 84/226 Gene Ontology BP GO:2000736 2.08761125862815e-05 4.6156090827669e-05 345 905 680 1.89784642593743e-06 341 1.86756049973941 2.05229570615521 1 9.59221798319132 341 2250 768 779 1980 647 503 570 680 819 618 467 M10819 GO_ACTIN_MYOSIN_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MYOSIN_FILAMENT_SLIDING.html The sliding movement of actin thin filaments and myosin thick filaments past each other. 26/58 Gene Ontology BP GO:0033275 5.23724210717749e-06 1.45346772884788e-05 110 735.909090909091 681 4.76114052255652e-07 108 3.13347927982932 3.35091539695219 1 17.9570238572542 108 916 363 681 1673 636 453 1053 208 961 1043 468 M13772 GO_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within an organism or cell. 46/109 Gene Ontology BP GO:0030104 9.65420750505193e-16 7.11499768983431e-14 1135 982.181818181818 681 8.7765522773199e-17 58 2.42888071061935 2.3342141800072 1 37.8301611176725 1133 539 58 405 378 1196 681 4261 746 127 1280 469 M14866 GO_MUSCLE_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FILAMENT_SLIDING.html The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. 26/58 Gene Ontology BP GO:0030049 5.23724210717749e-06 1.45346772884788e-05 110 736.818181818182 682 4.76114052255652e-07 109 3.13347927982932 3.35091539695219 1 17.9570238572542 109 917 364 682 1674 637 454 1051 209 964 1044 470 M12913 GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 24/48 Gene Ontology BP GO:0070169 3.45253483134171e-07 2.45108856604274e-06 685 809 684 3.13866852105442e-08 192 2.21456787609872 2.75881521028049 1 14.7190414604806 1150 681 767 439 478 1990 684 329 192 1121 1068 471 M13253 GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT.html The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. 64/205 Gene Ontology BP GO:0060538 9.18552045142721e-06 2.30034365997716e-05 385 843.181818181818 687 8.35050800306571e-07 379 2.38861337470827 2.67284585531583 1 13.1242368307999 381 2182 416 919 1733 699 753 379 494 632 687 472 M15176 GO_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. 358/940 Gene Ontology BP GO:0030155 3.34367356009495e-22 9.13216255265932e-20 535 862.636363636364 687 3.03970323644994e-23 16 1.8458258384751 2.02833985916185 1 41.6315580669023 531 625 16 569 687 1758 1605 978 1358 27 1335 473 M12870 GO_POSITIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION.html Any process that activates or increases the frequency, rate or extent of cell adhesion. 225/579 Gene Ontology BP GO:0045785 4.46633499115127e-13 1.95633899659579e-11 500 778.727272727273 688 4.06030453741108e-14 98 1.78541476182983 2.03367121246338 1 22.648951314189 498 744 98 688 382 1374 1299 651 1545 147 1140 474 M15199 GO_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 10/23 Gene Ontology BP GO:0009310 1.34862505838352e-05 3.18174092788348e-05 305 987.454545454545 688 1.22603029607245e-06 260 1.4117068699068 -1.52426260208801 -1 7.52103811116859 304 472 1636 1422 1847 260 518 688 999 2084 632 475 M13680 GO_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTION.html Self-propelled movement of a cell or organism from one location to another. 550/1674 Gene Ontology BP GO:0040011 1.28613326580726e-13 6.35267739696075e-12 400 908 689 1.28613326580733e-14 13 1.82474051138102 1.90643694186843 1 24.2037433546019 399 196 4114 128 418 750 1025 838 1418 13 689 476 M10497 GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH.html The activation of endogenous cellular processes that result in the death of a cell as part of its development. 20/41 Gene Ontology BP GO:0010623 1.68556032042128e-05 3.85900225232545e-05 450 990 690 1.53233930428409e-06 152 1.8060541471893 2.07560829187929 1 9.44266057459782 450 1696 1280 1736 2222 453 690 412 667 1132 152 477 M11796 GO_MEMBRANE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a membrane. 12/40 Gene Ontology BP GO:0071709 4.56797933634455e-06 1.30437441935103e-05 690 651.818181818182 690 4.15271711010491e-07 51 1.84856494191748 1.96777034517038 1 10.6964963862317 713 321 1131 690 1529 459 367 482 51 737 690 478 M13913 GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 18/47 Gene Ontology BP GO:0051954 4.85739502370185e-07 2.86654203278225e-06 375 551.636363636364 690 4.41581463288159e-08 43 2.2321814512324 2.62735873921381 1 14.6563001525526 372 142 805 749 993 703 573 43 185 690 813 479 M16048 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 18/29 Gene Ontology BP GO:0010662 3.43844016532126e-07 2.44717246315863e-06 180 789.090909090909 690 3.12585518429509e-08 172 2.4652201599755 2.56502346183406 1 16.3870205210032 1497 690 763 172 476 1707 1548 180 180 957 510 480 M16715 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 14/21 Gene Ontology BP GO:0010664 2.90072308209409e-07 2.20016607245287e-06 775 539.636363636364 690 2.63702133141594e-08 9 2.3912029874758 2.56502346183406 1 16.0259019812361 771 699 832 371 840 690 574 39 173 938 9 481 M11452 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. 12/24 Gene Ontology BP GO:2000725 1.66929101771906e-05 3.8236399581991e-05 350 1277.18181818182 691 1.51754880355494e-06 250 2.57660629861253 2.57660629861253 1 13.4835711694285 349 3888 1578 1712 2253 609 400 250 673 1646 691 482 M16217 GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS.html The process in which the branching structure of the salivary gland is generated and organized. 9/33 Gene Ontology BP GO:0060445 0.000276575831283512 0.000459113902270055 210 1367.81818181818 691 2.7661025970001e-05 210 2.54701300634192 2.54701300634192 1 10.0717717443135 210 1583 4529 877 2957 610 455 614 691 1934 586 483 M11625 GO_REGULATION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSITIVE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 16/34 Gene Ontology BP GO:0050926 2.92108350524581e-05 6.12859950965039e-05 235 940.727272727273 692 2.65556571917991e-06 109 2.08837532112758 2.08837532112758 1 10.4217536504571 232 2793 1060 1108 2310 290 109 300 692 1146 308 484 M14331 GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 29/118 Gene Ontology BP GO:0030816 1.28094044538797e-07 1.40269020941895e-06 240 888.363636363636 692 1.16449138179107e-08 64 1.72651981638552 1.84313624766269 1 11.9710148390938 239 915 692 1211 167 93 176 1107 3074 2034 64 485 M13427 GO_ENDOTHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 58/132 Gene Ontology BP GO:0003158 7.22452021445633e-09 1.53869024567526e-07 175 899.636363636364 695 6.56774567107339e-10 172 2.01109552059378 2.04099251897275 1 16.2307842885603 172 1469 198 994 2621 367 282 934 1783 695 381 486 M13542 GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. 39/94 Gene Ontology BP GO:0050891 2.52763578989348e-12 9.86202770796254e-11 1310 1099.09090909091 696 2.29785071808762e-13 110 2.46177909361445 2.36623722738554 1 29.18025754006 1309 546 110 408 460 1321 815 4526 696 249 1650 487 M15320 GO_RESPONSE_TO_MINERALOCORTICOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MINERALOCORTICOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. 20/50 Gene Ontology BP GO:0051385 8.44119266716294e-06 2.15224917922227e-05 235 789.727272727273 698 7.67384095945242e-07 100 2.40767131618599 2.40767131618599 1 13.311378890478 233 1799 830 929 1705 298 435 698 524 1136 100 488 M14727 GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. 59/151 Gene Ontology BP GO:1904064 1.01290543939484e-07 1.24087597760165e-06 690 895.454545454545 699 9.20823169118348e-09 120 1.61452651793898 1.70764667595183 1 11.2963108663689 686 651 1030 1440 120 657 699 702 2221 1071 573 489 M10771 GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 17/41 Gene Ontology BP GO:0043537 9.46102907637374e-06 2.35662864815468e-05 430 1073.27272727273 700 8.60097251224476e-07 198 1.73483996304162 1.8086217459343 1 9.51050263285621 430 2222 1753 1024 2170 697 700 198 395 1789 428 490 M14307 GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. 49/122 Gene Ontology BP GO:0006081 5.49552387355537e-07 3.07418281264067e-06 650 1401.45454545455 700 4.99593204210791e-08 167 1.37469559904052 -1.29184571808635 -1 8.97666605096243 650 2011 2359 2660 700 167 391 589 2346 3027 516 491 M15201 GO_MATURE_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION.html The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. 8/24 Gene Ontology BP GO:0002335 5.00683157897571e-07 2.89556769973244e-06 1305 1021.90909090909 701 5.00683270705237e-08 91 2.19028667354113 -1.5724816405354 -1 14.3698701630201 1304 177 4368 801 701 255 231 859 91 1757 697 492 M12265 GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. 24/72 Gene Ontology BP GO:1903792 3.44940084354417e-06 1.05643589159469e-05 275 700.545454545455 702 3.13582386536755e-07 272 2.12375250639983 2.20659138615246 1 12.5191836094228 272 918 583 702 1421 472 350 512 858 843 775 493 M13305 GO_VACUOLAR_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_ACIDIFICATION.html Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. 9/18 Gene Ontology BP GO:0007035 7.86832671960941e-06 2.02621414082898e-05 485 1119.45454545455 702 7.86835457950265e-07 332 1.8938522477583 -1.74144785371932 -1 10.5294042102501 483 332 4049 1207 1712 338 585 1112 702 1202 592 494 M14450 GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. 10/23 Gene Ontology BP GO:0042402 1.34862505838352e-05 3.18174092788348e-05 305 987.727272727273 706 1.22603029607245e-06 259 1.4117068699068 -1.52426260208801 -1 7.52103811116859 303 471 1635 1421 1846 259 517 706 998 2078 631 495 M12974 GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 16/43 Gene Ontology BP GO:0071377 2.20471299573563e-06 7.69082076574046e-06 490 1198.90909090909 707 2.00428655015893e-07 312 1.79402989094455 1.52302842184037 1 10.8685285880895 488 312 647 684 1241 707 583 4248 2151 808 1319 496 M16820 GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. 15/23 Gene Ontology BP GO:1900025 2.07634391083712e-06 7.35352004425382e-06 270 1244 708 1.88758715497992e-07 120 1.00987560222862 1.1204627245273 1 6.14129314841683 270 584 2366 1317 1223 428 120 708 2629 3344 695 497 M14392 GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoblast differentiation. 80/162 Gene Ontology BP GO:0045667 5.70931202711959e-08 8.44214514073766e-07 665 741.727272727273 709 5.19028379571303e-09 46 1.91330423392838 1.91182100335548 1 13.7658962175831 663 883 381 333 46 1160 991 1946 709 258 789 498 M11940 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. 50/126 Gene Ontology BP GO:0048640 6.24522454442896e-07 3.2678777741923e-06 755 730.636363636364 716 5.6774784702596e-08 433 1.88419636663701 2.06855484596579 1 12.2444410469981 753 541 520 433 757 1020 631 981 1187 498 716 499 M16105 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. 88/216 Gene Ontology BP GO:1903035 7.40864077424449e-08 1.01171526808286e-06 530 824.181818181818 716 6.73512820339563e-09 219 1.76856696625694 1.93656970883232 1 12.5598518328032 528 762 251 420 655 880 716 1767 1692 219 1176 500 M16467 GO_DERMATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. 7/14 Gene Ontology BP GO:0030205 1.75499626992949e-05 3.99238004962402e-05 170 1106.54545454545 716 1.75501013013713e-06 143 1.60267329629691 1.60267329629691 1 8.35129998535464 167 716 4569 1271 1957 190 143 765 415 1521 458 501 M15149 GO_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 13/35 Gene Ontology BP GO:0046058 1.24782581834518e-05 2.98911833640521e-05 245 1043.45454545455 718 1.13439354180817e-06 241 2.13864633264393 2.13864633264393 1 11.4626086161595 241 590 934 1472 1812 301 294 718 2998 1851 267 502 M13111 GO_OPTIC_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPTIC_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. 11/26 Gene Ontology BP GO:0021554 4.72022742798671e-06 1.33960977678131e-05 2235 1134.27272727273 719 4.29112505048953e-07 16 2.04428163572242 2.04428163572242 1 11.800953840939 632 2233 2112 1775 2108 345 16 149 719 2235 153 503 M14620 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 37/87 Gene Ontology BP GO:0071230 5.60819860518223e-07 3.10518604170987e-06 1225 1216.72727272727 720 5.09836366801289e-08 103 2.02172109905454 2.29747400831411 1 13.1912609679639 1223 103 386 559 708 2950 2975 1413 720 443 1904 504 M11397 GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 24/67 Gene Ontology BP GO:0009187 1.92351662670323e-05 4.30611750134189e-05 120 917.636363636364 726 1.74866676791823e-06 118 1.66717245838581 1.71425631749943 1 8.62251052427167 118 811 726 1350 1955 164 246 571 3095 841 217 505 M12779 GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. 34/99 Gene Ontology BP GO:0060401 1.3809595376079e-05 3.23991669182087e-05 410 1016.45454545455 727 1.25542564189976e-06 406 2.02575707518488 2.14773483926254 1 10.773581473856 406 1899 644 1085 1858 580 450 1015 1951 727 566 506 M16014 GO_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIOGENESIS.html Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. 54/139 Gene Ontology BP GO:0014013 5.27040421997113e-07 2.97564873462027e-06 730 864.636363636364 727 4.79127771142706e-08 183 2.38670448959911 2.85381819905658 1 15.6250156818996 727 1319 605 183 683 1602 1359 1311 211 702 809 507 M12944 GO_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MORPHOGENESIS.html The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. 30/93 Gene Ontology BP GO:0048813 3.85629208830143e-07 2.57804519639595e-06 1415 775.363636363636 728 3.50572069477784e-08 386 1.50442548588855 1.59961727425842 1 9.960020766873 728 555 864 456 520 855 386 1412 754 588 1411 508 M16717 GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of anion transport. 31/109 Gene Ontology BP GO:1903793 1.20385272130637e-05 2.90212262981594e-05 580 867.454545454545 729 1.09441755355322e-06 273 2.39279628295236 2.76176239563273 1 12.8611486229822 579 1088 729 640 1800 1242 1155 273 430 1003 603 509 M16433 GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION.html The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. 10/22 Gene Ontology BP GO:0060900 3.51591536767913e-06 1.06706110315891e-05 330 853.454545454545 730 3.19629180602587e-07 266 1.47658345914015 -1.46589228980303 -1 8.69662217189781 671 327 1481 1253 1432 326 266 613 909 1380 730 510 M10048 GO_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. 49/162 Gene Ontology BP GO:0021510 9.32843458246962e-06 2.331104508418e-05 295 846.090909090909 731 8.48043103373616e-07 108 1.70448851140893 1.72713464398214 1 9.35366348620524 295 971 731 1430 1739 427 108 499 1556 853 698 511 M10138 GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. 8/30 Gene Ontology BP GO:0019682 1.93973053023921e-06 6.98277533440277e-06 340 1329 732 1.93973222339083e-07 10 1.49486355302246 -1.49486355302246 -1 9.13040662401497 338 1293 3540 2230 2563 210 10 581 609 2513 732 512 M15773 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. 10/22 Gene Ontology BP GO:0055026 7.98654295345046e-05 0.000147970945462372 735 1147.09090909091 732 7.26075718127853e-06 109 3.41504248625407 3.41504248625407 1 15.493621103275 732 2898 1258 459 2737 899 533 432 109 2088 473 513 M15376 GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT.html The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis. 17/38 Gene Ontology BP GO:0090662 3.57891126050796e-05 7.29450613807658e-05 690 1240.54545454545 735 3.25360862069952e-06 269 1.41563960342452 -1.50117929424673 -1 6.93771814668557 690 2064 2504 1318 2151 269 660 477 735 2331 447 514 M11147 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 12/37 Gene Ontology BP GO:0055012 6.53812362485437e-06 1.73863161455892e-05 975 873.545454545455 736 5.9437664140157e-07 141 2.94522847630759 3.16260063010595 1 16.6067658495586 973 2198 730 803 1641 1016 544 197 141 736 630 515 M16155 GO_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 212/571 Gene Ontology BP GO:0097305 1.65495954248995e-19 2.64964729509685e-17 845 880.545454545455 737 1.50450867499087e-20 25 2.05200767874865 2.29892170920872 1 40.2956416322018 843 25 28 80 737 2214 2611 733 1278 81 1056 516 M11267 GO_CELLULAR_COMPONENT_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MAINTENANCE.html The organization process that preserves a cellular component in a stable functional or structural state. 10/26 Gene Ontology BP GO:0043954 6.028403357319e-08 8.80184804655099e-07 1575 1023.54545454545 738 5.48036683864393e-09 39 1.54541338431458 1.21892683630349 1 11.0858096129442 1571 167 1814 1003 53 738 405 3718 385 1366 39 517 M14345 GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. 12/42 Gene Ontology BP GO:0055083 1.77231508482138e-06 6.5308404276394e-06 285 1053.18181818182 739 1.61119682963278e-07 42 1.5065670011213 1.5065670011213 1 9.25375132613815 284 2232 1731 1833 2398 183 42 88 1939 739 116 518 M15566 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 22/65 Gene Ontology BP GO:0010596 2.83971642619217e-06 9.08670114873208e-06 195 1021.27272727273 740 2.58156371968047e-07 108 1.52617943829931 1.55218279081195 1 9.11489074904417 191 2147 1736 1291 2682 202 161 108 740 1820 156 519 M13724 GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of heart contraction. 22/57 Gene Ontology BP GO:0045823 1.30024641430063e-06 5.32367204726438e-06 475 724.090909090909 741 1.18204289343121e-07 28 2.15553284595538 2.4478168195614 1 13.4665211734825 475 817 741 543 1094 232 244 933 1533 1325 28 520 M13942 GO_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_MORPHOGENESIS.html The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. 293/783 Gene Ontology BP GO:0048598 6.5029093203217e-14 3.39247280609592e-12 355 723.727272727273 741 5.91173574574715e-15 83 1.82857373058707 1.95273096054924 1 24.8447376035614 352 741 83 526 523 839 867 1241 1594 244 951 521 M10963 GO_POSITIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LOCOMOTION.html Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. 278/658 Gene Ontology BP GO:0040017 5.25872132129652e-16 4.06937384912996e-14 60 719.545454545455 742 4.78065574663321e-17 56 1.77609239379357 1.83909235651773 1 28.1734173726668 337 742 56 479 905 602 947 984 1879 60 924 522 M15453 GO_REGULATION_OF_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_SPECIFICATION.html Any process that mediates the adoption of a specific fate by a cell. 10/24 Gene Ontology BP GO:0042659 2.46461161352269e-05 5.32489144792268e-05 515 1170.81818181818 742 2.24058111314326e-06 162 1.21344873091228 1.29798322326707 1 6.1433089123091 515 606 1351 1539 2352 316 162 742 3730 1377 189 523 M10170 GO_HINDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). 79/247 Gene Ontology BP GO:0030902 1.81906787321759e-06 6.63552696228699e-06 600 839.545454545455 743 1.65369943392167e-07 260 1.89436845764979 2.14810096376439 1 11.6202370508902 599 1534 743 605 1179 585 648 260 1158 946 978 524 M10964 GO_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of dendrite morphogenesis. 46/125 Gene Ontology BP GO:0048814 1.84241252610019e-06 6.69803448568157e-06 325 901.090909090909 743 1.67492188095385e-07 237 1.55521601534585 1.58334024549173 1 9.53234135604877 324 1839 1803 1103 1184 237 248 743 1376 610 445 525 M12688 GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. 4/16 Gene Ontology BP GO:2001053 2.55457679201073e-06 8.46649428237867e-06 745 1024.72727272727 743 2.55457972865365e-07 29 3.56197922737578 3.56197922737578 1 21.4029714392298 743 349 3951 116 1351 1054 902 533 29 1699 545 526 M10034 GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. 3/22 Gene Ontology BP GO:0042053 4.06810785479642e-07 2.61980478260637e-06 1275 888.272727272727 745 4.06810859952418e-08 31 2.48153461385199 3.46141101052175 1 16.4084403519194 1274 185 3520 745 1132 1164 136 40 31 1414 130 527 M10326 GO_NEURON_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_RECOGNITION.html The process in which a neuronal cell in a multicellular organism interprets its surroundings. 17/63 Gene Ontology BP GO:0008038 5.66825466731199e-08 8.40821291384331e-07 465 1200.90909090909 745 5.15295892123036e-09 45 1.81348842862903 2.06045166285884 1 13.0514961130167 463 2554 1502 2110 45 659 696 745 1987 1786 663 528 M15705 GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. 14/55 Gene Ontology BP GO:0042462 6.1233765002161e-07 3.23212152206309e-06 1975 1455.63636363636 745 5.5667074586987e-08 155 1.86402990496828 1.8361693452779 1 12.1239402464194 1972 155 678 645 745 2829 2759 3388 590 333 1918 529 M16665 GO_NEUROTROPHIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. 20/34 Gene Ontology BP GO:0038179 4.50165437954253e-08 6.96706042807198e-07 745 836.090909090909 745 4.09241315605061e-09 36 1.48269283506023 1.66226963662931 1 10.8142120101349 745 300 1547 880 36 870 1120 652 488 2143 416 530 M16783 GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 62/155 Gene Ontology BP GO:0010717 7.59711937778388e-06 1.97278664826905e-05 405 888.363636363636 745 6.90649601141588e-07 404 1.74722680349302 1.87022623304584 1 9.73821911805698 404 1889 879 778 1677 683 481 827 723 686 745 531 M15930 GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. 3/22 Gene Ontology BP GO:0042069 3.75166983563841e-07 2.5617691856508e-06 1275 976.727272727273 746 3.75167046901475e-08 32 2.48153461385199 3.46141101052175 1 16.4370401957239 1275 186 4481 746 1133 1165 137 36 32 1422 131 532 M14509 GO_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. 21/82 Gene Ontology BP GO:0046530 3.78314057279405e-08 6.16320058929221e-07 1205 884.818181818182 749 3.43921876168118e-09 28 1.75724738836901 1.70307950970901 1 12.9275461798692 1201 129 749 539 28 1385 1526 2197 671 278 1030 533 M12884 GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. 32/73 Gene Ontology BP GO:0019935 3.78341969447647e-06 1.1305000062821e-05 60 862.818181818182 750 3.43947836452366e-07 28 1.89440128236057 1.89440128236057 1 11.1011551267444 59 1164 750 1252 2157 38 28 242 2298 1432 71 534 M13312 GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 93/217 Gene Ontology BP GO:0010771 2.47428549352098e-07 2.00203502611962e-06 775 887.636363636364 752 2.24935070163435e-08 245 1.55741096948324 1.53128543484117 1 10.5134190003575 772 245 671 327 377 1209 752 1475 1740 679 1517 535 M16782 GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 184/547 Gene Ontology BP GO:0034762 5.90669256336239e-07 3.2075758563382e-06 730 990.636363636364 752 5.3697219538431e-08 248 1.5752052295784 1.70474619576675 1 10.251557304223 837 514 495 752 727 726 1099 2320 1954 248 1225 536 M11069 GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of epithelial cell migration. 117/251 Gene Ontology BP GO:0010632 3.66942101536126e-07 2.53906434788708e-06 415 929.545454545455 753 3.3358378430827e-08 287 1.70538027376537 1.6881080646927 1 11.3038058543836 413 753 287 700 1498 875 731 1683 1564 411 1310 537 M14639 GO_HEART_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_DEVELOPMENT.html The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. 21/47 Gene Ontology BP GO:0003170 9.87045034405087e-06 2.44418671719617e-05 705 991.545454545455 755 8.97317693525366e-07 356 1.81322273602293 1.99751002894021 1 9.90617118047414 704 1185 893 1537 1757 594 741 755 1726 659 356 538 M10857 GO_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ACTIVATION.html A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. 90/224 Gene Ontology BP GO:0030168 6.71423124763873e-07 3.41822101784941e-06 465 702.272727272727 757 6.10384845161044e-08 298 2.11821678429231 2.35484339923768 1 13.7162047691241 465 527 298 834 871 982 876 622 757 341 1152 539 M16570 GO_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_GROWTH.html The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. 88/205 Gene Ontology BP GO:0016049 3.84458191110636e-07 2.57804519639595e-06 765 785.636363636364 761 3.49507507541956e-08 473 1.68931418340331 2.04986977148381 1 11.1840731343807 819 765 761 705 519 473 522 928 1491 930 729 540 M13918 GO_RETINOIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. 6/33 Gene Ontology BP GO:0042573 2.08560733348542e-06 7.37507604674242e-06 685 1172.45454545455 763 2.08560929087908e-07 52 2.58605353049177 2.66478598027873 1 15.7225133626976 682 1950 4157 624 1649 1244 763 280 189 1307 52 541 M11086 GO_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. 121/310 Gene Ontology BP GO:0007009 1.57543627887151e-07 1.56968897914172e-06 1100 996.454545454545 766 1.43221490153607e-08 262 1.85579906520601 1.94042992910468 1 12.7599903699248 1096 382 266 419 651 1398 1603 2882 766 262 1236 542 M16573 GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. 9/31 Gene Ontology BP GO:0032331 2.21749694235587e-07 1.91728832464773e-06 535 1272.63636363636 768 2.21749716363407e-08 8 1.85720966279833 1.85720966279833 1 12.5785596737877 534 2171 4584 768 1355 211 169 1986 277 1936 8 543 M15042 GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of muscle tissue development. 33/88 Gene Ontology BP GO:1901863 1.40502697480056e-06 5.61567159777016e-06 450 1052.54545454545 769 1.27729806556355e-07 185 2.039320293427 2.25877654773343 1 12.6844686213325 448 2462 721 1027 1069 591 769 673 2165 1468 185 544 M10483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. 23/50 Gene Ontology BP GO:0048662 2.35045989464884e-07 1.96311268848144e-06 770 864.545454545455 771 2.13678195069988e-08 357 2.03962109433022 2.15792663041967 1 13.7892162993686 768 447 708 999 357 1103 1065 1574 771 597 1121 545 M12103 GO_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_EFFLUX.html The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 9/31 Gene Ontology BP GO:0033344 1.37469222688093e-05 3.22847547263943e-05 510 1216.45454545455 771 1.3747007309592e-06 412 2.38797166968421 2.38797166968421 1 12.7042933098772 509 1987 3850 1116 1877 771 535 528 600 1196 412 546 M10384 GO_INTERMEDIATE_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. 25/72 Gene Ontology BP GO:0045103 1.29802257154529e-06 5.31925754605894e-06 810 679.909090909091 773 1.18002121581141e-07 127 2.49294863152705 2.75054547317738 1 15.5755638643377 810 282 319 195 1061 1296 1405 811 127 400 773 547 M15848 GO_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 263/825 Gene Ontology BP GO:0043269 3.89321663739075e-11 1.29115748910037e-09 775 992.818181818182 773 3.53928785223605e-12 72 1.73509102878851 1.90713045771973 1 18.2706604896142 773 214 129 742 667 1152 1423 2715 1585 72 1449 548 M11696 GO_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that modulates the frequency, rate, or extent of leukocyte migration. 73/208 Gene Ontology BP GO:0002685 1.05040116422667e-07 1.27201868213151e-06 580 882.909090909091 778 9.54910194889646e-09 255 1.77449183703186 1.7881591971845 1 12.3929064643323 577 889 255 955 766 619 778 1097 2512 270 994 549 M11998 GO_FOREBRAIN_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_CELL_MIGRATION.html The orderly movement of a cell from one site to another at least one of which is located in the forebrain. 23/93 Gene Ontology BP GO:0021885 6.3550314421307e-06 1.70262036848314e-05 440 759.818181818182 779 5.77731799970062e-07 163 1.74657441900404 1.82077182518896 1 9.86692245685101 436 809 818 498 2101 606 886 163 779 1033 229 550 M14412 GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). 38/201 Gene Ontology BP GO:0007188 1.30442106228354e-07 1.41836697709192e-06 140 729.909090909091 780 1.18583739965919e-08 136 1.86330665086309 1.81035544570756 1 12.9087871952356 136 794 780 956 172 233 255 830 2200 1525 148 551 M13601 GO_REGULATION_OF_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS.html Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. 10/27 Gene Ontology BP GO:0042481 3.51626855014676e-06 1.06706110315891e-05 785 971 781 3.19661288202275e-07 119 2.79881484489715 3.28750506468609 1 16.4841596376714 781 2165 707 822 1557 1087 649 119 199 2071 524 552 M11151 GO_POSITIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. 254/658 Gene Ontology BP GO:0043410 8.13574184338763e-11 2.45287333628888e-09 1575 821.909090909091 782 7.39612894880774e-12 122 1.73587204279075 1.79397767386778 1 17.7057899314412 665 1143 142 629 389 907 1117 1572 1573 122 782 553 M11460 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/65 Gene Ontology BP GO:0010765 1.37042653665088e-06 5.51855195981792e-06 755 1151.45454545455 782 1.24584308210846e-07 570 1.76274642691279 1.57918201757067 1 10.980014229444 751 570 1055 637 1060 782 601 4611 749 1032 818 554 M12339 GO_REGULATION_OF_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_AGGREGATION.html Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. 10/26 Gene Ontology BP GO:0090330 6.67676339319876e-07 3.41753794909904e-06 795 712.454545454545 783 6.06978674502318e-08 238 2.14420194687837 2.0523641353847 1 13.8846883945146 793 326 559 906 783 886 1040 1338 238 391 577 555 M13032 GO_EMBRYONIC_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PATTERN_SPECIFICATION.html The process that results in the patterns of cell differentiation that will arise in an embryo. 32/93 Gene Ontology BP GO:0009880 2.07324402669028e-07 1.84881304042245e-06 1045 991.454545454545 785 1.88476747460858e-08 313 2.29041238874941 2.27083699908199 1 15.5554216044872 1041 561 485 330 313 1814 1297 2172 785 651 1457 556 M14048 GO_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. 280/697 Gene Ontology BP GO:0001944 4.26238280254528e-23 1.23689020951361e-20 85 763.181818181818 786 3.87489345685933e-24 15 2.00232975308362 2.02395373879415 1 47.2208820161258 81 628 15 786 1349 701 810 1376 1686 64 899 557 M14185 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 60/165 Gene Ontology BP GO:0002065 1.37732605204087e-07 1.45339201355131e-06 2100 1217.72727272727 786 1.25211467115398e-08 97 2.05588762452322 2.40322149359144 1 14.2171661124991 2100 891 370 97 191 3248 3043 786 346 440 1883 558 M14206 GO_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTION_POTENTIAL.html A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. 37/148 Gene Ontology BP GO:0001508 6.13542240097329e-09 1.31604115281788e-07 1560 1324 786 5.57765674371266e-10 90 2.2012618108176 2.56027594183324 1 17.9425559866054 1559 786 196 467 733 2461 1940 3793 272 90 2267 559 M11532 GO_REGULATION_OF_WATER_LOSS_VIA_SKIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WATER_LOSS_VIA_SKIN.html A process that modulates the rate or extent of water loss from an organism via the skin. 17/34 Gene Ontology BP GO:0033561 3.59688203590704e-09 8.43450671349313e-08 180 1601.81818181818 787 3.2698927652616e-10 138 2.63532850052041 -2.48269038168262 -1 22.083821007523 3798 138 180 671 787 2648 4006 2330 176 232 2654 560 M13402 GO_AMINOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 83/196 Gene Ontology BP GO:0006022 1.66852369096823e-06 6.26776334722126e-06 255 938.909090909091 787 1.51684086946461e-07 253 1.76674711303178 1.76236130818633 1 10.8892220218685 253 1152 526 1938 1142 500 553 1088 1645 787 744 561 M10338 GO_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT.html Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 36/89 Gene Ontology BP GO:0046324 1.85436964013195e-06 6.73169526124521e-06 790 762.545454545455 790 1.68579200288475e-07 324 1.70137239720117 1.7027192465684 1 10.4237858471851 790 420 607 324 1188 955 961 1055 982 542 564 562 M13617 GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 19/45 Gene Ontology BP GO:0060314 1.9530092455508e-07 1.77452483896132e-06 625 1126.27272727273 790 1.77546310811418e-08 143 1.57765342481764 1.88601084684848 1 10.7479789510532 623 1758 1447 1578 299 540 790 143 2372 2561 278 563 M16052 GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Ras protein signal transduction. 98/239 Gene Ontology BP GO:0046578 3.62131924168836e-08 5.99281766227978e-07 805 811.090909090909 790 3.29210845572477e-09 21 1.83154795662484 2.02258748917873 1 13.5005698389334 805 51 261 46 21 2467 1668 790 818 239 1756 564 M16721 GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. 9/30 Gene Ontology BP GO:0090025 1.0786203536821e-05 2.63719552509003e-05 245 1374.63636363636 791 1.07862558911626e-06 212 1.82089490512655 1.82089490512655 1 9.87688625883754 244 1658 4610 1577 2300 339 226 212 2386 778 791 565 M16808 GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase A. 9/16 Gene Ontology BP GO:0034199 1.88736792202697e-06 6.82417804908999e-06 110 1239.63636363636 791 1.88736952499984e-07 11 1.4409912407175 1.4409912407175 1 8.81839460652997 110 333 4620 791 1222 76 11 1496 2867 1938 172 566 M12140 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. 74/160 Gene Ontology BP GO:2001237 8.98089671410061e-06 2.25762335915372e-05 1080 967.909090909091 793 8.16448488759838e-07 375 1.64888570238087 1.90996316434411 1 9.07570467336756 1077 530 533 732 1727 1158 1373 457 1892 793 375 567 M14192 GO_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REMODELING.html The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. 74/161 Gene Ontology BP GO:0048771 2.631093292765e-09 6.33727315807646e-08 795 688.545454545455 794 2.39190299628333e-10 51 1.86385383982266 1.95119813966744 1 15.893064203532 794 645 177 364 849 1205 966 563 974 51 986 568 M15911 GO_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 177/435 Gene Ontology BP GO:0001525 5.55855653112378e-17 5.2670159130628e-15 795 849.272727272727 794 5.05323321011253e-18 46 2.02494683380144 2.05144073769153 1 34.2509266291623 132 747 46 794 1469 792 907 1542 1860 160 893 569 M12819 GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 118/257 Gene Ontology BP GO:0051495 3.58833200642354e-07 2.49410561464439e-06 800 803.727272727273 796 3.26212053791105e-08 114 1.8227493084092 1.93374635147266 1 12.0985188836598 796 754 631 114 496 954 826 1518 1101 972 679 570 M10687 GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. 31/54 Gene Ontology BP GO:0045599 1.5833034821886e-06 6.06541094703108e-06 800 817.363636363636 799 1.43936783787908e-07 382 1.99554379616704 2.15829013134888 1 12.3330865119024 799 560 555 544 1114 1625 1100 633 845 382 834 571 M13723 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. 13/32 Gene Ontology BP GO:1902307 5.404376386211e-07 3.0304975315432e-06 645 1272.63636363636 800 4.91307064892298e-08 289 1.94176673695388 1.71437956795592 1 12.6938993833253 645 931 1601 800 698 578 289 4355 1127 2479 496 572 M11856 GO_REGULATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 158/473 Gene Ontology BP GO:0042391 1.2388380020841e-09 3.16039826575632e-08 1155 860.363636363636 801 1.12621636616519e-10 32 1.84380158816686 2.02815712873433 1 16.3820578562269 1153 32 168 202 196 1077 924 3751 801 129 1031 573 M15971 GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 15/23 Gene Ontology BP GO:0048011 2.46455355196546e-07 2.00203502611962e-06 915 778.363636363636 802 2.24050348005228e-08 196 1.66484089253264 1.77557770441442 1 11.2386328308712 912 694 1365 802 374 986 1108 410 196 1477 238 574 M13346 GO_CARDIAC_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_FATE_COMMITMENT.html The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. 4/19 Gene Ontology BP GO:0060911 3.37557307739518e-06 1.03930940307333e-05 405 1102.45454545455 803 3.37557820492827e-07 184 3.97916693679371 3.97916693679371 1 23.4900182185575 609 184 4057 302 1450 803 937 1282 401 1701 401 575 M15026 GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 515/1522 Gene Ontology BP GO:0071495 2.38838449194917e-07 1.98022664216428e-06 735 1099.18181818182 805 2.38838474864633e-08 117 1.83239189118698 2.00546156265614 1 12.3800239804297 733 359 4335 250 397 818 1187 1628 1462 117 805 576 M15950 GO_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 125/310 Gene Ontology BP GO:0007584 1.31400874975781e-09 3.33384842903034e-08 1125 1033.09090909091 805 1.19455340958421e-10 169 1.92554382531639 2.26288135461454 1 17.0554032556505 1123 236 169 423 805 2594 2672 635 1117 355 1235 577 M11169 GO_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORT.html A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 78/301 Gene Ontology BP GO:0098656 1.15868314058161e-06 4.89960457351584e-06 650 868.636363636364 806 1.05334886439138e-07 336 1.52803229324014 1.58615430876813 1 9.6115163439492 601 646 806 1349 999 678 821 1115 1555 649 336 578 M14841 GO_MUSCLE_FIBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FIBER_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. 20/79 Gene Ontology BP GO:0048747 3.17558693709395e-05 6.5646705916862e-05 610 1003 806 2.88693888725973e-06 132 3.64249370325217 3.8829689445072 1 18.0485628795337 610 2400 469 541 2118 1171 806 506 132 833 1447 579 M16730 GO_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. 188/476 Gene Ontology BP GO:0048589 1.30316071184477e-07 1.41836697709192e-06 810 848.454545454545 806 1.18469162639723e-08 171 1.71835717557325 1.79838412706937 1 11.9045927576333 806 373 480 592 171 994 1050 1835 1612 398 1022 580 M10966 GO_CELLULAR_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 10/27 Gene Ontology BP GO:0071285 5.67011146765458e-07 3.12293327927879e-06 810 1477.36363636364 808 5.15464811729655e-08 44 2.79862745509792 2.79862745509792 1 18.2521896410702 808 3320 1577 2365 3540 671 590 44 315 2807 214 581 M16211 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. 41/115 Gene Ontology BP GO:0032755 1.51701397514156e-07 1.53788119794373e-06 3105 1270.63636363636 808 1.37910370886141e-08 216 1.67750160314511 -1.62215428608676 -1 11.551731179516 3105 664 881 274 216 1686 3462 625 808 688 1568 582 M16600 GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 49/125 Gene Ontology BP GO:0043266 6.71120257978472e-07 3.41822101784941e-06 375 1114.90909090909 808 6.10109511551748e-08 373 1.4226873019644 1.51372079132156 1 9.21240419355854 373 896 871 1163 788 396 414 3381 2709 465 808 583 M10568 GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/97 Gene Ontology BP GO:0032890 4.95439535629944e-06 1.39081338911221e-05 715 970.818181818182 809 4.504005921475e-07 476 2.06551982358983 2.314331984612 1 11.8836942560076 715 986 773 758 1558 1105 809 1523 476 692 1284 584 M10825 GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. 12/22 Gene Ontology BP GO:0034114 3.37771727622692e-08 5.74459388773685e-07 4210 2060 809 3.07065211644172e-09 18 2.45673493785899 -2.40651799948516 -1 18.1623691951313 4206 594 809 761 18 4435 3946 2659 90 735 4407 585 M13415 GO_BLOOD_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. 220/539 Gene Ontology BP GO:0048514 5.36750779254313e-21 1.08353646438164e-18 125 698.727272727273 811 4.87955253867556e-22 22 2.00882900104358 2.03352420474261 1 42.7515690079288 122 510 22 627 881 811 931 1334 1503 70 875 586 M15205 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. 14/41 Gene Ontology BP GO:0035850 2.70775476880402e-06 8.79783442376282e-06 815 863.818181818182 811 2.46159827409808e-07 72 2.47443830529023 2.8225595299936 1 14.819360668366 811 316 418 72 1335 1491 1026 1568 193 474 1798 587 M11087 GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. 32/90 Gene Ontology BP GO:0046928 5.15869880941661e-07 2.94248631107142e-06 1755 1114.18181818182 813 4.68972729005569e-08 421 1.77118454321744 1.85580280184369 1 11.6056089106294 522 1753 1398 2330 672 447 421 813 1752 1431 717 588 M13117 GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 31/45 Gene Ontology BP GO:0010837 5.55085198318332e-07 3.09395027105884e-06 495 817.818181818182 813 5.04623034884304e-08 248 2.14424237233524 2.66797424329015 1 13.9946828237638 491 1399 1077 1255 704 813 819 248 293 1334 563 589 M12221 GO_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_EXTRAVASATION.html The migration of a leukocyte from the blood vessels into the surrounding tissue. 20/37 Gene Ontology BP GO:0045123 3.20527726487847e-07 2.32896750247743e-06 815 865.181818181818 814 2.91388884715417e-08 428 2.02387636857837 -1.34984829012228 -1 13.5048317545401 814 575 428 855 457 673 1066 1342 1986 829 492 590 M13694 GO_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. 21/60 Gene Ontology BP GO:0086003 2.83514579121768e-07 2.17485745049544e-06 2170 1566.09090909091 814 2.5774055968943e-08 277 2.03189485075334 2.21558142507766 1 13.6299041096782 2168 814 509 751 414 2407 1877 4549 550 277 2911 591 M14957 GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM.html The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. 18/51 Gene Ontology BP GO:0001738 7.20670432388254e-08 9.9289994586904e-07 1440 790.909090909091 815 6.55154959996178e-09 66 2.01905538183976 2.52198811176756 1 14.3582484314792 1440 145 1082 335 66 1799 880 815 100 1346 692 592 M10713 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN.html The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. 17/37 Gene Ontology BP GO:0050965 6.69364726833821e-06 1.7698521792081e-05 820 839.090909090909 816 6.08515239481349e-07 203 2.35735540195423 2.38197508754482 1 13.270439296229 816 1260 833 618 1650 552 203 1416 665 879 338 593 M13795 GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 9/15 Gene Ontology BP GO:0030207 2.44208424566313e-06 8.19855180955454e-06 485 1163.90909090909 816 2.44208692936624e-07 12 1.79384952605659 1.79384952605659 1 10.8084357370159 484 1288 4133 1678 1805 102 12 816 504 1916 65 594 M14909 GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. 19/58 Gene Ontology BP GO:0031952 9.51662022637582e-07 4.24862189529451e-06 175 788.181818181818 816 8.65147667547038e-08 34 1.50151969337541 1.59269413210135 1 9.55487490078343 391 1905 1786 816 1154 172 34 61 1141 1039 171 595 M15576 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. 17/37 Gene Ontology BP GO:0050961 6.69364726833821e-06 1.7698521792081e-05 820 841.909090909091 817 6.08515239481349e-07 204 2.35735540195423 2.38197508754482 1 13.270439296229 817 1261 834 619 1651 553 204 1435 666 882 339 596 M15775 GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 73/203 Gene Ontology BP GO:0043271 3.87264784107596e-07 2.57804519639595e-06 670 955.363636363636 817 3.52058956616016e-08 458 1.59117598696239 1.86354593804696 1 10.5343509322604 670 766 661 827 524 817 897 2054 1739 458 1096 597 M13534 GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. 5/22 Gene Ontology BP GO:0021514 2.26674230983325e-06 7.80748111613931e-06 820 1259.90909090909 818 2.26674462199088e-07 99 2.78687053919202 2.78687053919202 1 16.8617364801256 818 727 4093 1009 3099 856 363 99 505 1978 312 598 M11377 GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. 44/102 Gene Ontology BP GO:0008652 4.17692078450159e-07 2.64473610582847e-06 995 898.545454545455 820 3.79720143412012e-08 389 1.83096071854597 2.01676654110623 1 12.0977835093069 994 413 1135 573 577 1459 672 1343 389 820 1509 599 M11817 GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 9/33 Gene Ontology BP GO:0061217 4.36293912658758e-06 1.26134037140387e-05 820 1129.54545454545 820 4.36294769246826e-07 144 1.60887954600116 1.79609996674595 1 9.33735476895841 820 1121 3811 712 1542 418 144 820 1522 1195 320 600 M16883 GO_POSITIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIOGENESIS.html Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. 26/67 Gene Ontology BP GO:0014015 1.73116441314284e-06 6.41996515193469e-06 1170 1013.63636363636 821 1.57378706853214e-07 153 2.41416904925819 2.87643473823098 1 14.849762332453 1170 434 821 222 1161 2157 1678 1850 153 721 783 601 M15404 GO_ADULT_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. 6/29 Gene Ontology BP GO:0007512 2.76614969905134e-06 8.9375316998576e-06 490 1197.45454545455 822 2.76615314227024e-07 129 3.81772039889016 3.81772039889016 1 22.8333083614405 489 2372 4399 1007 1383 694 356 209 129 1312 822 602 M10800 GO_RESPONSE_TO_DIETARY_EXCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DIETARY_EXCESS.html The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. 9/30 Gene Ontology BP GO:0002021 5.95307274284214e-07 3.22186943838406e-06 825 1090.09090909091 825 5.95307433760112e-08 102 2.30259484809831 2.07453299244179 1 14.9801987214948 825 847 3639 653 776 1208 1496 1300 102 769 376 603 M12749 GO_POSITIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 139/394 Gene Ontology BP GO:0043270 7.56608107068022e-07 3.65169588473682e-06 420 784 825 6.87825788432128e-08 237 1.76826030801328 1.98539382044901 1 11.3900055868268 420 875 323 825 845 762 1012 987 1554 237 784 604 M10640 GO_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 225/596 Gene Ontology BP GO:1901652 6.22817383948932e-08 9.03669098023403e-07 1780 1220.18181818182 829 5.66197637800742e-09 219 1.66433317929809 1.69568243821425 1 11.9163181416795 829 219 244 591 690 2064 1681 3226 1778 323 1777 605 M16575 GO_POSITIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXONOGENESIS.html Any process that activates or increases the frequency, rate or extent of axonogenesis. 46/107 Gene Ontology BP GO:0050772 8.02026785418792e-08 1.07314419731973e-06 80 812.727272727273 830 7.29115286052081e-09 76 1.73875300263059 2.01686714104249 1 12.2953923232661 365 2186 1027 1533 76 317 830 78 1309 1128 91 606 M13602 GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS.html The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. 53/145 Gene Ontology BP GO:0044236 8.12845395306127e-12 2.90310859262027e-10 245 719.545454545455 831 7.38950359371935e-13 102 2.2642009586987 2.20178392211882 1 25.5806191293969 243 404 121 852 484 1190 1142 1491 831 102 1055 607 M14476 GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a cardiac muscle cell. 24/74 Gene Ontology BP GO:0086001 1.81096325837907e-08 3.46020675253253e-07 1530 1295.18181818182 831 1.64633024844208e-09 106 2.27275394774547 2.54565207497419 1 17.3949570965835 1528 565 216 348 831 2257 1598 4589 227 106 1982 608 M10093 GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 54/171 Gene Ontology BP GO:0008277 2.34728594024077e-08 4.27390141981879e-07 835 1003.54545454545 833 2.13389633207737e-09 12 1.64670564237606 1.82074380638557 1 12.4244517053154 833 540 665 1720 12 757 472 1247 2586 877 1330 609 M12814 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. 14/35 Gene Ontology BP GO:0045987 1.54002872358268e-06 5.97169304825377e-06 760 786.636363636364 833 1.4000270923854e-07 74 1.89133196803863 2.23803093237964 1 11.7041766259662 760 465 812 833 1371 842 1016 74 840 1390 250 610 M13878 GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 269/752 Gene Ontology BP GO:1901699 1.33538938867654e-07 1.42862049115788e-06 835 939.363636363636 834 1.21399042703094e-08 19 1.66273121689689 1.73972690287016 1 11.5130603326167 834 19 271 497 181 1651 1407 1879 1947 503 1144 611 M15680 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 56/201 Gene Ontology BP GO:0070588 3.22451762957135e-07 2.3356373407332e-06 465 804.909090909091 834 2.93138009289611e-08 305 1.78401824597539 1.88749361744125 1 11.9016922204508 511 1076 465 945 462 760 879 834 1730 305 887 612 M14770 GO_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 28/98 Gene Ontology BP GO:0014902 5.85227518235261e-07 3.18921521967877e-06 955 902.363636363636 836 5.32025158102871e-08 347 2.89031701719547 3.50534696390804 1 18.8189440037428 951 1171 347 542 723 1451 836 1007 532 644 1722 613 M14946 GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 84/207 Gene Ontology BP GO:0051896 4.21372278035883e-07 2.6545881776399e-06 455 927 837 3.83065780675036e-08 188 1.64929424904019 1.81403308328775 1 10.8942958720339 451 1609 837 188 582 964 1479 1181 1614 681 611 614 M16709 GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 200/469 Gene Ontology BP GO:0071214 3.75190857797962e-07 2.5617691856508e-06 840 992.909090909091 838 3.4108265616683e-08 201 1.704670022168 1.95043672371055 1 11.2912905634821 838 1371 885 2145 512 774 812 239 2147 998 201 615 M11713 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 75/200 Gene Ontology BP GO:0034764 2.3761351245659e-07 1.97659046554909e-06 830 984.090909090909 839 2.16012307382102e-08 360 1.65375214914528 1.7201122097614 1 11.174659978307 828 767 796 839 360 1057 1154 1307 2037 592 1088 616 M12211 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. 14/40 Gene Ontology BP GO:0099623 1.28401966486062e-05 3.05885238786447e-05 765 976.454545454545 839 1.16729741731119e-06 473 2.09196397029135 2.3248954162244 1 11.1875828512973 764 839 684 1311 1824 1128 900 704 728 473 1386 617 M10535 GO_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COCAINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. 28/70 Gene Ontology BP GO:0042220 9.74234364109059e-08 1.20623204068223e-06 1950 841.090909090909 840 8.85667642955867e-09 17 1.95701244218743 2.05698091940687 1 13.7210820249901 145 2192 1063 840 1948 57 23 17 978 1947 42 618 M10559 GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cation channel activity. 25/56 Gene Ontology BP GO:2001259 8.45556089841716e-06 2.15472937713232e-05 580 968.454545454545 841 7.68690308818701e-07 222 1.71250151366777 1.68304605935436 1 9.4669534483316 576 805 1537 1520 1706 672 464 222 1126 1184 841 619 M10653 GO_CELLULAR_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 260/821 Gene Ontology BP GO:0071396 2.71104687822594e-14 1.57342383195038e-12 780 893.727272727273 844 2.46458807111451e-15 75 1.92716466302974 2.0071057332181 1 26.9460419774104 778 1057 75 223 844 1377 1651 1135 1659 197 835 620 M12364 GO_NEURAL_CREST_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_MIGRATION.html The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. 24/70 Gene Ontology BP GO:0001755 2.25355053727111e-06 7.77288853033298e-06 390 921.181818181818 844 2.04868440516271e-07 285 1.69150677064664 1.86505130757716 1 10.238189579898 386 285 406 578 1254 914 613 1678 2275 844 900 621 M16445 GO_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cell proliferation. 806/2183 Gene Ontology BP GO:0042127 7.50559032524195e-11 2.29923457862557e-09 745 1213.81818181818 844 7.50559032549545e-12 25 1.72845745157454 1.90325750799918 1 17.6876812908188 744 736 4568 570 235 1424 1537 868 1801 25 844 622 M12173 GO_EMBRYO_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT.html The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. 469/1244 Gene Ontology BP GO:0009790 7.5756428214344e-13 3.16880266846125e-11 525 760 848 6.88694801948819e-14 81 1.7749968928902 1.90240435615627 1 22.0763838519357 523 1052 102 861 81 848 946 993 1755 361 838 623 M16582 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 642/1720 Gene Ontology BP GO:0010648 2.41119994952966e-07 1.98730728824007e-06 870 1119.09090909091 848 2.41120021115453e-08 193 1.62470468351387 1.81858343614418 1 10.9738619948637 870 193 4586 321 399 972 1084 754 1899 384 848 624 M15548 GO_CELL_VOLUME_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_VOLUME_HOMEOSTASIS.html Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. 19/45 Gene Ontology BP GO:0006884 4.85317191520597e-07 2.86654203278225e-06 1170 1205.63636363636 849 4.4119754416453e-08 290 2.07831312390501 1.91096038623188 1 13.6460146102182 1168 818 587 995 637 849 434 4480 1963 1041 290 625 M10230 GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that activates or increases the frequency, rate or extent of reproductive process. 28/84 Gene Ontology BP GO:2000243 4.98309345102646e-08 7.61069174115653e-07 1780 1407.63636363636 851 4.53008505808696e-09 41 2.04162589005537 2.39565692019457 1 14.798052583472 1779 435 585 170 41 2823 3109 3570 782 851 1339 626 M16683 GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 9/30 Gene Ontology BP GO:0061213 4.36293912658758e-06 1.26134037140387e-05 825 1206.72727272727 851 4.36294769246826e-07 145 1.60887954600116 1.79609996674595 1 9.33735476895841 821 1122 4604 713 1543 419 145 851 1523 1212 321 627 M10213 GO_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 30/102 Gene Ontology BP GO:0051339 4.57105717520734e-08 7.05096958953079e-07 855 1182.36363636364 852 4.15550660925693e-09 39 1.27866330466075 1.45318659427975 1 9.31822053845315 852 117 1228 1357 39 488 407 2364 3266 2103 785 628 M15871 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. 43/118 Gene Ontology BP GO:1900076 7.68713267827337e-07 3.68331857845441e-06 605 1095.18181818182 852 6.98830487661372e-08 301 1.5176642808979 1.6148235620298 1 9.76909312286191 604 1544 1472 938 852 572 676 731 2077 2280 301 629 M11707 GO_INSEMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSEMINATION.html The introduction of semen or sperm into the genital tract of a female. 6/18 Gene Ontology BP GO:0007320 0.000207329296143764 0.000353129098310893 855 1340.27272727273 853 2.07348642130774e-05 242 1.81620459510644 2.08131364112756 1 7.42714539921002 637 853 3792 1990 2619 603 242 853 1465 757 932 630 M14669 GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. 170/456 Gene Ontology BP GO:0048871 1.58444013715476e-12 6.39700483200830e-11 855 908.272727272727 853 1.44040012468718e-13 106 2.15782838039553 2.21071704154279 1 26.0579710473475 853 515 106 574 843 1316 1262 1674 1097 322 1429 631 M13002 GO_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. 149/391 Gene Ontology BP GO:0046883 1.42864514732084e-05 3.33829865073512e-05 715 1197 855 1.29877674981859e-06 484 1.60330701539593 1.69565811005094 1 8.50219093772434 711 1604 521 1325 1865 586 855 2137 2264 484 815 632 M14927 GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. 62/168 Gene Ontology BP GO:0055067 2.78984296142442e-06 8.99530615964832e-06 720 1058.09090909091 855 2.53622409023607e-07 456 1.82800652888151 -1.84105745961137 -1 10.9270178067699 719 1613 799 1473 1346 456 1530 720 1289 839 855 633 M12252 GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of muscle contraction. 27/61 Gene Ontology BP GO:0045933 1.38656526493167e-06 5.56423727318732e-06 595 857.181818181818 857 1.26051467165892e-07 361 1.85685034629985 2.11301764370126 1 11.5583046349172 593 441 857 1045 1065 621 978 361 1611 1407 450 634 M16068 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. 14/30 Gene Ontology BP GO:1901380 2.76549078627444e-07 2.14002895344537e-06 1140 983.363636363636 857 2.51408284900737e-08 409 1.55380333062713 1.7724182102632 1 10.435781905598 1139 695 1415 787 409 898 766 2424 952 475 857 635 M10902 GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any neuron projection extension that is involved in neuron projection guidance. 5/17 Gene Ontology BP GO:1902284 0.000235433344166984 0.000396775686739495 295 1238.27272727273 858 2.35458290873608e-05 291 3.35384544736139 3.35384544736139 1 13.5140591739223 291 858 3655 1038 2654 390 451 839 984 1962 499 636 M11070 GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. 16/46 Gene Ontology BP GO:0045747 5.88170950162872e-07 3.20149791513038e-06 1600 1049.72727272727 858 5.34701006736989e-08 46 2.34369917409284 3.05150451120508 1 15.2552630192091 1599 825 1005 383 858 2816 1979 46 64 1143 829 637 M15092 GO_PROSTATE_GLAND_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_GROWTH.html The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. 5/17 Gene Ontology BP GO:0060736 7.67493971223972e-05 0.000143284057434375 655 1424.81818181818 858 7.67520479627314e-06 255 2.68948701263182 -2.68948701263182 -1 12.2464021401523 655 2079 4350 1323 2618 480 858 438 255 1984 633 638 M11804 GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE.html The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. 5/17 Gene Ontology BP GO:0048846 0.000235433344166984 0.000396775686739495 295 1253.45454545455 859 2.35458290873608e-05 292 3.35384544736139 3.35384544736139 1 13.5140591739223 292 859 3809 1039 2655 391 452 836 985 1970 500 639 M13923 GO_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. 13/54 Gene Ontology BP GO:0055078 8.01692125879224e-06 2.05877021042989e-05 545 848.454545454545 859 7.28813679367656e-07 165 2.39578815091648 -2.64468593298735 -1 13.3004116878696 544 1420 865 942 2167 450 1284 181 165 859 456 640 M14753 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 457/1268 Gene Ontology BP GO:0051093 1.08343498395558e-14 6.61893240856021e-13 860 928.272727272727 860 9.84940894505075e-16 71 1.82194274036963 1.9779510554783 1 26.2864531207137 860 501 71 587 816 1620 1389 1180 1717 154 1316 641 M14159 GO_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 625/1567 Gene Ontology BP GO:0009628 1.6512900539858e-07 1.61692190219132e-06 865 1118.63636363636 861 1.65129017668996e-08 169 1.73911994944258 2.01019449626469 1 11.9312092305509 861 194 4193 685 264 1332 1185 976 1596 169 850 642 M14994 GO_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_ACTIVATION.html Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 19/56 Gene Ontology BP GO:0010543 9.42312228874993e-06 2.35097027332971e-05 385 1159.45454545455 861 8.56651150041984e-07 378 2.21467228044482 2.16341150521618 1 12.1437132887292 382 1931 378 1387 2466 628 861 1618 1779 573 751 643 M14978 GO_REGULATION_OF_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUTAMATE_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of glutamate. 9/26 Gene Ontology BP GO:0014048 4.42289758563844e-06 1.2703362945654e-05 460 1106.18181818182 863 4.42290638857346e-07 147 3.06816288289115 3.06816288289115 1 17.7952909283008 458 1024 4327 828 1827 957 358 147 169 1210 863 644 M12333 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 79/210 Gene Ontology BP GO:0090288 1.37264164511363e-07 1.45174832762246e-06 545 885.545454545455 865 1.24785611886964e-08 189 1.6705185955572 1.68369601066678 1 11.5531796647972 542 1887 1127 240 189 865 1071 817 1341 947 715 645 M13417 GO_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. 18/65 Gene Ontology BP GO:0042461 9.66625583347943e-08 1.20322857466072e-06 1105 862.272727272727 865 8.78750568926435e-09 113 1.77790266860022 1.72470953519442 1 12.4675807955857 1103 140 788 865 113 1172 1481 1922 628 267 1006 646 M13940 GO_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell. 225/577 Gene Ontology BP GO:0040007 1.09729189329493e-07 1.29465148368895e-06 870 767.909090909091 866 9.97538134567685e-09 132 1.75138800156511 1.93010052252988 1 12.2156600252539 866 370 294 477 132 1066 1072 1565 1267 251 1087 647 M16011 GO_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). 117/281 Gene Ontology BP GO:0046777 4.85907621929996e-07 2.86654203278225e-06 390 1289.54545454545 867 4.41734299319125e-08 388 1.4151282996772 1.45115141948469 1 9.29160294245936 431 1833 2096 1860 638 388 463 867 2341 2879 389 648 M10347 GO_METENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. 58/189 Gene Ontology BP GO:0022037 1.12773874244928e-07 1.30763867947327e-06 985 892.545454545455 868 1.02521709114376e-08 139 1.99627181981083 2.42054346931034 1 13.9134357453903 982 1890 591 650 139 1169 1172 416 717 868 1224 649 M14319 GO_OLFACTORY_LOBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_LOBE_DEVELOPMENT.html The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. 16/61 Gene Ontology BP GO:0021988 2.23578864738943e-07 1.920433592552e-06 1250 846 869 2.03253534055038e-08 148 1.96370999008979 2.08004512006727 1 13.2982120822693 1248 148 869 375 335 1358 1575 1335 361 1150 552 650 M16681 GO_SYNCYTIUM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNCYTIUM_FORMATION.html The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. 16/57 Gene Ontology BP GO:0006949 6.29576001416648e-07 3.28071983678732e-06 1490 1030.36363636364 874 5.72341983257324e-08 585 2.06829720361926 2.61660571773475 1 13.4366461941833 1489 585 874 920 761 1961 838 766 807 1153 1180 651 M14579 GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 81/224 Gene Ontology BP GO:0050731 2.4759017970363e-05 5.34431057351907e-05 585 1173.45454545455 875 2.25084514683587e-06 190 1.69656337136412 1.74375850989268 1 8.58598959638978 585 2491 1216 1810 2315 430 629 304 2063 875 190 652 M16233 GO_REGULATION_OF_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. 20/51 Gene Ontology BP GO:0060306 1.26935281184968e-06 5.23410755365726e-06 910 785.090909090909 875 1.15395776749056e-07 242 1.90936248133474 2.0931672925438 1 11.9452579624324 439 999 524 909 1036 713 801 1188 875 242 910 653 M10474 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE.html Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. 8/21 Gene Ontology BP GO:0090178 2.17972844004888e-07 1.89522081407247e-06 880 1327.27272727273 878 2.17972865385363e-08 363 1.53659039690086 1.53683355961534 1 10.4162121923593 878 609 3593 709 363 970 1164 2481 2416 661 756 654 M11730 GO_RRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_TRANSCRIPTION.html The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. 11/27 Gene Ontology BP GO:0009303 7.43844869152662e-07 3.61865792670656e-06 1080 1136.36363636364 878 6.76222836959218e-08 224 1.30088675290353 -1.16503427743523 -1 8.38556531051958 1076 936 2347 2034 836 416 278 224 553 2922 878 655 M14248 GO_RESPONSE_TO_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TEMPERATURE_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. 100/246 Gene Ontology BP GO:0009266 2.15450377656087e-06 7.57256702087217e-06 445 1126.90909090909 878 1.95864171501108e-07 289 1.67824925651451 1.80815205817831 1 10.1804892595078 441 1919 670 2016 1231 289 460 1635 2382 878 475 656 M14370 GO_RESPONSE_TO_CORTICOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. 12/34 Gene Ontology BP GO:0051412 0.000242874385804375 0.000407835722708757 190 978.272727272727 878 2.20819275146895e-05 186 2.50783633767364 2.50783633767364 1 10.069658597148 186 1910 1039 1406 2652 346 417 878 324 1117 486 657 M14078 GO_CELLULAR_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 37/74 Gene Ontology BP GO:0031670 7.31018809539409e-07 3.58407638087801e-06 540 923.272727272727 879 6.64562774948533e-08 335 2.06483512965797 2.17206726131404 1 13.3202071437201 537 792 335 1025 825 1125 1869 955 1372 442 879 658 M16624 GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of cation transmembrane transport. 117/316 Gene Ontology BP GO:1904062 1.10105383208303e-07 1.29465148368895e-06 1090 1047.45454545455 879 1.00095807926224e-08 133 1.53470401540239 1.77641405694764 1 10.7043225775152 879 523 896 1089 133 608 1088 2249 2551 699 807 659 M11684 GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html A process in which a protein is transported to, or maintained in, the cell periphery. 84/212 Gene Ontology BP GO:1990778 5.65726085001122e-07 3.11955607204301e-06 2430 1711.90909090909 882 5.14296573160573e-08 306 1.67558430035068 1.66237618426927 1 10.9288182838249 2428 882 810 306 712 3308 2699 3808 586 518 2774 660 M10208 GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION.html The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. 6/25 Gene Ontology BP GO:0021889 2.42537442694492e-05 5.25724251368127e-05 1030 1178.63636363636 883 2.42540089833654e-06 124 1.61470460015734 -1.61470460015734 -1 8.18536294800214 1028 183 3553 1593 2047 295 124 676 883 2168 415 661 M13171 GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS.html The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. 20/73 Gene Ontology BP GO:0001658 8.43465848881321e-07 3.9201320684244e-06 2740 1507.45454545455 884 7.66787429328069e-08 134 1.88732567313385 -1.58731854987662 -1 12.0880738731795 2738 134 636 162 884 3511 2739 3416 183 618 1561 662 M12087 GO_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION.html The attachment of one cell to another cell via adhesion molecules. 290/888 Gene Ontology BP GO:0098609 4.86946858731733e-27 5.65223566272859e-24 950 804.727272727273 885 4.42678962483392e-28 4 1.9137103149706 2.0802648059605 1 52.7030522599955 948 505 4 194 362 1726 1471 1390 885 12 1355 663 M15023 GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of glia cell differentiation. 37/97 Gene Ontology BP GO:0045685 8.10393719724998e-07 3.80450762455325e-06 985 978.818181818182 886 7.36721834765833e-08 232 2.53012024979868 3.02299610126302 1 16.2440601941624 985 1620 693 462 870 1336 1239 1794 232 886 650 664 M15393 GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-glutamate across a membrane. 5/13 Gene Ontology BP GO:0089711 5.2114452888449e-05 0.00010179529018135 870 1564.36363636364 886 5.21156750910789e-06 317 2.68348100124955 2.68348100124955 1 12.6910257736738 867 2291 4395 1907 2845 853 471 389 317 1987 886 665 M12132 GO_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGING.html A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). 170/435 Gene Ontology BP GO:0007568 3.00283061668935e-09 7.07722972248155e-08 935 902.272727272727 887 2.72984601889817e-10 179 1.87917795615487 2.13813073169523 1 15.9169668007469 935 376 179 273 887 2101 2082 668 1143 321 960 666 M12776 GO_EMBRYONIC_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_MORPHOGENESIS.html Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 152/440 Gene Ontology BP GO:0048562 4.35718858500958e-11 1.43478202838294e-09 890 1070.18181818182 887 3.96108053190533e-12 130 1.84079588353344 2.00445552922615 1 19.2838540815609 887 231 130 228 275 2292 1726 2311 1649 212 1831 667 M11634 GO_THIOESTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 44/99 Gene Ontology BP GO:0035383 8.51359158986866e-07 3.9340057015628e-06 95 1293.81818181818 888 7.73963171315667e-08 25 1.26384280843886 -1.04377097695455 -1 8.09245009932271 400 416 2692 2797 888 25 92 1659 1735 3435 93 668 M10099 GO_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMORY.html The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). 43/156 Gene Ontology BP GO:0007613 1.49018738784441e-07 1.52735983261846e-06 865 930.818181818182 889 1.35471589889404e-08 208 2.04777372340722 2.15453617856921 1 14.108758251728 863 1749 889 218 208 1389 1194 1114 773 765 1077 669 M15311 GO_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 44/99 Gene Ontology BP GO:0006637 8.51359158986866e-07 3.9340057015628e-06 95 1280.18181818182 889 7.73963171315667e-08 26 1.26384280843886 -1.04377097695455 -1 8.09245009932271 401 417 2693 2798 889 26 93 1499 1736 3436 94 670 M16142 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. 38/115 Gene Ontology BP GO:0002690 9.86262281955832e-06 2.44355164093966e-05 745 1268.18181818182 890 8.96606094006929e-07 303 1.62796604331892 1.67048206873696 1 8.89427664587222 741 1969 572 1883 1756 854 890 752 2990 303 1240 671 M10339 GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 160/477 Gene Ontology BP GO:0045861 1.176925700571e-06 4.9407468605345e-06 895 1046.63636363636 891 1.0699330274427e-07 530 1.75233284177753 1.87611437042109 1 11.0148568271408 891 2085 641 1829 1007 530 956 579 1704 701 590 672 M12411 GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. 8/17 Gene Ontology BP GO:0050655 5.94960662181088e-06 1.61449582379123e-05 350 1197.36363636364 891 5.94962255088943e-07 348 1.60267329629691 1.60267329629691 1 9.09780208674545 348 940 3904 1474 1643 431 459 891 584 1740 757 673 M15200 GO_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. 50/124 Gene Ontology BP GO:0019218 7.52020348985254e-07 3.64090769586917e-06 2115 1336.45454545455 891 6.83655096405964e-08 431 2.09669045790344 -1.69601138947106 -1 13.5087350272601 2113 780 891 431 842 927 1695 3425 460 887 2250 674 M15038 GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. 22/69 Gene Ontology BP GO:0048483 1.97395724011564e-05 4.39577759341003e-05 675 1012.18181818182 893 1.79452268339493e-06 671 2.19698842436149 2.88787969028432 1 11.3393929733091 747 812 672 970 1964 893 976 915 695 1819 671 675 M12586 GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 4/20 Gene Ontology BP GO:0022010 1.4989996281165e-06 5.85846403480211e-06 2000 1563.72727272727 896 1.49900063926741e-07 19 3.44690055672014 3.97916693679371 1 21.3644887878975 1997 490 3935 206 1136 3677 4000 383 19 896 462 676 M11130 GO_GLIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DEVELOPMENT.html The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 46/123 Gene Ontology BP GO:0021782 3.75740860527287e-07 2.5617691856508e-06 975 1075.81818181818 897 3.41582658818703e-08 513 1.84109521057507 1.96553719220962 1 12.1949356395853 975 897 1227 770 513 1690 1990 626 687 1783 676 677 M12986 GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM.html The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 4/20 Gene Ontology BP GO:0032291 1.4989996281165e-06 5.85846403480211e-06 2000 1567.81818181818 897 1.49900063926741e-07 20 3.44690055672014 3.97916693679371 1 21.3644887878975 1998 491 3990 207 1137 3678 4001 364 20 897 463 678 M11203 GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 5/13 Gene Ontology BP GO:0009313 0.000106062840450101 0.000191316926266441 340 1328.90909090909 898 1.06067902986927e-05 340 1.65834754062486 -1.65834754062486 -1 7.30452101386786 340 1363 3709 1675 2820 432 444 473 499 1965 898 679 M11525 GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. 16/41 Gene Ontology BP GO:1900026 3.11544289823683e-07 2.29236734544433e-06 3675 2113.27272727273 899 2.83222121765276e-08 306 1.51259898102641 -1.25826069197198 -1 10.105528963836 3674 306 899 677 448 3427 4407 4415 654 804 3535 680 M11688 GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle tissue development. 67/167 Gene Ontology BP GO:1901861 8.91634530414869e-07 4.08270130642627e-06 900 982.454545454545 899 8.10577174349296e-08 48 1.98297118655926 2.30579094618022 1 12.6592172649565 594 2540 1050 899 899 469 610 272 1604 1822 48 681 M11882 GO_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 288/754 Gene Ontology BP GO:0010035 4.64676387315469e-18 5.53203196488647e-16 1010 757 899 4.22433079377699e-19 15 1.9645946930534 2.21062064955096 1 35.507776406979 1008 15 38 63 193 1975 1857 899 1250 103 926 682 M10337 GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-5 production. 7/42 Gene Ontology BP GO:0032674 5.00992291183325e-06 1.40380640190958e-05 905 1090.54545454545 901 5.0099342065665e-07 339 1.79596040177428 -1.9731847836585 -1 10.3242279612613 901 946 3567 1223 1588 512 563 339 403 1493 461 683 M10729 GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 203/467 Gene Ontology BP GO:0071496 6.26055860574924e-07 3.2678777741923e-06 790 1152.81818181818 901 5.69141853392946e-08 396 1.77430999562004 1.96148153054337 1 11.5303448941714 788 2419 396 1773 758 767 1287 901 1900 971 721 684 M16019 GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. 4/17 Gene Ontology BP GO:0007171 8.54270047091525e-07 3.93489665540273e-06 1030 1151 901 8.54270375491493e-08 28 2.28131117759875 1.98655088341834 1 14.6070876479113 1029 618 4494 421 926 1534 860 1473 28 901 377 685 M11906 GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 21/53 Gene Ontology BP GO:0045744 4.02448152921893e-08 6.46562897583511e-07 1065 991.636363636364 902 3.6586196389447e-09 32 1.60213236323533 1.98417543231181 1 11.7469258402838 1064 451 1124 1140 32 902 487 659 2554 1681 814 686 M14318 GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. 48/121 Gene Ontology BP GO:0032231 1.36948145080251e-06 5.51855195981792e-06 800 1014.90909090909 902 1.24498391208537e-07 420 1.82009674825131 1.77390366986538 1 11.3372451000865 800 1391 902 716 1059 691 420 1384 1674 1230 897 687 M11551 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. 22/70 Gene Ontology BP GO:0003333 1.34723474324497e-06 5.44314265028097e-06 1180 805.090909090909 903 1.22475960751319e-07 294 1.98475954838918 1.96287186733262 1 12.3769666822825 687 1179 1049 903 1055 1162 1178 294 398 555 396 688 M12259 GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. 17/55 Gene Ontology BP GO:0043534 2.60768717626232e-06 8.56864229255907e-06 250 853 903 2.37062751562843e-07 102 2.20059042219763 2.20059042219763 1 13.2091755015179 249 1978 903 1070 2364 171 148 102 1025 1234 139 689 M15173 GO_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. 74/169 Gene Ontology BP GO:0001952 4.17441145234779e-06 1.21821447977692e-05 410 963.363636363636 904 3.7949267028605e-07 354 1.78832426106786 1.96287381789501 1 10.4107942950228 409 1381 354 806 1788 1056 771 904 1472 405 1251 690 M14013 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of organic acid across a membrane. 40/133 Gene Ontology BP GO:1903825 1.11179133058503e-05 2.6998154539259e-05 905 875.090909090909 905 1.01072449924552e-06 146 1.88791746522958 1.86692952146754 1 10.2176362167798 639 901 755 905 1787 910 1060 305 1189 1029 146 691 M16537 GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. 102/257 Gene Ontology BP GO:0014074 8.14715778342669e-07 3.81707907047932e-06 765 883 905 7.40650981866121e-08 306 1.82326323170529 1.8597912288638 1 11.7027509640578 763 391 306 499 985 905 1085 1410 1766 533 1070 692 M10863 GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL.html The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 13/53 Gene Ontology BP GO:0086010 4.38915001393955e-06 1.26616711933525e-05 980 846 907 3.99014433692507e-07 198 2.48474056794057 3.00035830260788 1 14.4156537250975 976 1010 907 689 1513 1003 655 555 198 856 944 693 M11224 GO_CEREBELLAR_CORTEX_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 21/57 Gene Ontology BP GO:0021696 6.16322377420059e-07 3.23818309264637e-06 4495 2069.18181818182 907 5.60293227346096e-08 325 1.86137085930405 -1.54031117671865 -1 12.1048511355907 4492 683 798 325 752 4510 2937 2726 523 907 4108 694 M10937 GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that activates or increases the activity of a transporter. 42/118 Gene Ontology BP GO:0032411 4.45762068768502e-07 2.74343418554066e-06 615 917.090909090909 908 4.05238326444043e-08 602 1.71210226168942 1.7247266675628 1 11.2801720290946 613 977 1213 1130 602 834 715 709 1226 1161 908 695 M13891 GO_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 32/61 Gene Ontology BP GO:0071616 5.18133787191118e-07 2.94576129913833e-06 580 1294.81818181818 908 4.71030826563293e-08 113 1.31159807380709 -1.04018942743947 -1 8.59343770886716 580 908 2432 2567 673 113 200 1906 1498 3094 272 696 M15448 GO_THIOESTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 32/61 Gene Ontology BP GO:0035384 5.18133787191118e-07 2.94576129913833e-06 585 1291.36363636364 909 4.71030826563293e-08 114 1.31159807380709 -1.04018942743947 -1 8.59343770886716 581 909 2433 2568 674 114 201 1858 1499 3095 273 697 M10752 GO_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 29/52 Gene Ontology BP GO:0034405 1.61959138817313e-06 6.14359707131359e-06 610 920.818181818182 910 1.47235689134705e-07 392 1.69736436916227 1.76185984918467 1 10.4790592266933 607 1090 615 392 1127 1215 877 644 1617 910 1035 698 M11155 GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. 46/125 Gene Ontology BP GO:0044259 1.71263699976441e-09 4.25228534219581e-08 205 804.181818181818 910 1.5569427282706e-10 173 2.20843965354016 2.2700731843569 1 19.2846720999177 205 657 173 910 1566 1011 866 1136 1063 205 1054 699 M12397 GO_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 22/76 Gene Ontology BP GO:0090183 9.22263471680007e-07 4.18989168200614e-06 1375 1025.63636363636 910 8.3842168936629e-08 81 2.3176865469253 2.30644726381808 1 14.7651265342695 1373 131 449 81 910 1363 1241 3313 340 556 1525 700 M14457 GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 298/724 Gene Ontology BP GO:0051493 6.21389397372343e-07 3.25633292550766e-06 765 1383.54545454545 910 5.64899611712433e-08 627 1.73076462880833 1.89208023640145 1 11.2505168081275 761 3137 910 2297 755 965 689 627 2092 2267 719 701 M12371 GO_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BEHAVIOR.html Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 23/91 Gene Ontology BP GO:0050795 1.29869047204753e-05 3.08746536698242e-05 915 983.818181818182 911 1.18063467132784e-06 649 1.69555767497137 2.24058420321392 1 9.05952535759662 911 992 841 1049 1832 999 656 649 798 782 1313 702 M14234 GO_NEGATIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GROWTH.html Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. 136/323 Gene Ontology BP GO:0045926 1.08467653309511e-06 4.65448534488041e-06 735 1112 912 9.86070061707951e-08 421 1.70118482973798 1.83139782890767 1 10.7455865949034 734 2180 831 1451 976 931 912 685 2293 818 421 703 M15518 GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 25/58 Gene Ontology BP GO:0061001 8.13819017488999e-06 2.08529895044229e-05 285 1036.18181818182 912 7.39838207241334e-07 198 1.55591419966925 1.51812720524649 1 8.62753411604561 285 1972 1794 1460 1695 411 198 660 1237 912 774 704 M16377 GO_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that modulates the extent to which blood vessels can be pervaded by fluid. 11/38 Gene Ontology BP GO:0043114 4.69715606944769e-09 1.04850459761758e-07 530 1100.36363636364 912 4.27014189043314e-10 5 1.24741929077599 1.40509617872048 1 10.3136032703826 527 1815 1853 1698 912 238 376 5 2186 2246 248 705 M10295 GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 10/24 Gene Ontology BP GO:0009084 4.23946918691491e-06 1.23409751942608e-05 670 1110.27272727273 915 3.85407032411582e-07 173 2.15165943767389 2.15165943767389 1 12.5116241292986 668 1862 2081 1649 1503 915 344 173 242 2054 722 706 M15920 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT.html Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. 11/25 Gene Ontology BP GO:0061311 8.60899625642883e-07 3.96150343098108e-06 2665 1572.54545454545 915 7.82636329571451e-08 262 2.40582963868086 3.0671270605586 1 15.3960303026068 2665 599 915 651 892 4623 3607 1401 262 990 693 707 M10164 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 7/24 Gene Ontology BP GO:0051968 2.22877442751016e-07 1.920433592552e-06 1050 1003.72727272727 916 2.22877465104478e-08 29 2.1460725680374 2.50729463950708 1 14.5331686473124 1048 336 3547 369 1750 1157 1727 29 56 916 106 708 M12576 GO_MACROMOLECULAR_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_REMODELING.html The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. 9/28 Gene Ontology BP GO:0034367 8.62059124006301e-06 2.18718060806626e-05 775 1435.27272727273 916 8.62062468181258e-07 495 1.98788096294682 1.88653065634158 1 10.9740030571467 774 1207 3934 1307 1742 888 495 3087 916 771 667 709 M10737 GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN.html Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. 2/16 Gene Ontology BP GO:2000047 0.00057545912182833 0.000905714136491165 1200 1515.2 917 6.39562615975298e-05 195 1.53561774604294 -1.53561774604294 -1 5.53559499484177 1198 863 3627 NA 4169 648 432 764 195 2285 971 710 M14867 GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). 9/28 Gene Ontology BP GO:0034369 8.62059124006301e-06 2.18718060806626e-05 775 1469.36363636364 917 8.62062468181258e-07 496 1.98788096294682 1.88653065634158 1 10.9740030571467 775 1208 4308 1308 1743 889 496 3077 917 774 668 711 M15611 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 20/48 Gene Ontology BP GO:0050654 2.58088800134542e-06 8.51674697245686e-06 135 847.909090909091 917 2.34626457188171e-07 14 1.89980348738652 1.89980348738652 1 11.4096212514446 133 1257 917 2065 1317 48 14 678 1700 1137 61 712 M12681 GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/33 Gene Ontology BP GO:0051953 3.08403308730433e-06 9.68165356616228e-06 465 1104.81818181818 918 3.08403736737972e-07 110 2.97269639975697 2.97269639975697 1 17.657016296735 462 1360 3948 538 1415 1249 714 357 110 918 1082 713 M16168 GO_PROTEIN_LIPID_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_REMODELING.html The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. 9/28 Gene Ontology BP GO:0034368 8.62059124006301e-06 2.18718060806626e-05 780 1488.36363636364 918 8.62062468181258e-07 497 1.98788096294682 1.88653065634158 1 10.9740030571467 776 1209 4521 1309 1744 890 497 3063 918 776 669 714 M15683 GO_CARDIAC_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. 32/69 Gene Ontology BP GO:0060411 9.29886058432431e-07 4.19986475613013e-06 895 1214.72727272727 919 8.45351319520638e-08 406 1.62108552511631 1.67522868201002 1 10.3253549362509 895 907 843 1400 919 1419 1739 1507 2497 406 830 715 M15943 GO_REGULATION_OF_CELL_SHAPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SHAPE.html Any process that modulates the surface configuration of a cell. 82/204 Gene Ontology BP GO:0008360 8.04680332341538e-07 3.79688087709529e-06 520 984.545454545455 919 7.31527842422377e-08 520 1.79893982210734 2.01699225520508 1 11.5515396689168 520 1739 811 1122 865 885 919 535 1359 1048 1027 716 M12264 GO_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CONTRACTION.html A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. 76/194 Gene Ontology BP GO:0006941 1.59617814683761e-08 3.07512661235146e-07 1295 1016.90909090909 923 1.45107105310768e-09 214 2.22966781501498 2.73481023145804 1 17.2005269690784 1292 1072 214 296 579 1423 923 2705 512 317 1853 717 M13363 GO_POSITIVE_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HAIR_CYCLE.html Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 5/13 Gene Ontology BP GO:0042635 1.3205858675168e-06 5.36907196399344e-06 1260 1144.63636363636 923 1.32058665229362e-07 152 2.87681237736693 2.89119312762698 1 17.9600904479716 1260 1219 4061 790 1084 923 152 2024 187 625 266 718 M14080 GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/58 Gene Ontology BP GO:0010828 2.2394353579162e-05 4.90688927173426e-05 550 1057.45454545455 923 2.03587104910643e-06 546 1.50881651725312 1.60454497978126 1 7.70212312719283 546 919 1449 1084 1998 766 851 784 1089 1223 923 719 M16636 GO_ESTROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 10/50 Gene Ontology BP GO:0008210 2.30679391721139e-06 7.8854890531668e-06 925 921.909090909091 924 2.09708757816985e-07 66 2.03639185235427 2.39249087216561 1 12.3106092171645 924 846 1522 630 1268 1301 1064 309 66 2093 118 720 M14816 GO_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_DISASSEMBLY.html A process that results in the breakdown of the extracellular matrix. 44/149 Gene Ontology BP GO:0022617 2.26147129175479e-07 1.93727144051983e-06 2880 1826.54545454545 925 2.05588320383713e-08 281 2.03707309101218 -1.67114287533101 -1 13.7858771710234 2878 409 281 902 337 4527 4358 1638 925 352 3485 721 M14226 GO_MONOSACCHARIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSPORT.html The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 26/83 Gene Ontology BP GO:0015749 3.5087919288469e-07 2.47965310892483e-06 1090 1001 926 3.18981135315104e-08 380 1.75930775579467 1.76047002598619 1 11.6826849099791 1088 564 535 522 483 1667 926 2679 380 963 1204 722 M16849 GO_RESPONSE_TO_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. 50/150 Gene Ontology BP GO:0014823 3.72043265932575e-07 2.55493418140588e-06 930 1081.90909090909 928 3.38221208044582e-08 506 1.97584998249118 2.37611463299173 1 13.0902320936873 928 1471 530 894 506 1176 1409 794 1593 1675 925 723 M16180 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 71/173 Gene Ontology BP GO:0090101 9.50906187534301e-07 4.24862189529451e-06 390 1048.36363636364 931 8.64460544131648e-08 389 1.72968646325707 1.75830000067686 1 11.0068074568927 389 2385 1266 515 931 912 1221 717 1338 1181 677 724 M16583 GO_HEMOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOSTASIS.html The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. 183/448 Gene Ontology BP GO:0007599 8.89934613425686e-06 2.24188548050892e-05 555 1152.45454545455 931 8.09034739428727e-07 417 1.85614796485204 2.02414746339718 1 10.2231864396337 554 2421 417 1726 1722 925 1126 542 1437 876 931 725 M13157 GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). 14/36 Gene Ontology BP GO:0001941 1.88035967716311e-06 6.80476226116005e-06 3620 1572.54545454545 934 1.70941934938661e-07 96 1.62733772594393 -0.87921484721664 -1 9.96115971455441 3616 691 919 295 1193 4362 3969 117 96 934 1106 726 M13236 GO_RELAXATION_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_MUSCLE.html A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. 19/37 Gene Ontology BP GO:0090075 3.48319170441076e-07 2.46531388469195e-06 1195 1048.63636363636 934 3.16653841444892e-08 482 2.12910681464119 2.06484428936503 1 14.1446889098786 1191 689 1125 763 482 1083 840 2361 934 1450 617 727 M14468 GO_RESPONSE_TO_VITAMIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. 20/35 Gene Ontology BP GO:0033197 6.50076399934259e-07 3.34994975016067e-06 710 916.363636363636 935 5.90978720022674e-08 236 2.17603398662931 2.55090580786557 1 14.1131777090816 707 293 297 236 1384 1323 1232 1719 935 454 1500 728 M14888 GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. 20/59 Gene Ontology BP GO:0032881 6.34614690505522e-06 1.70172557435588e-05 2590 1311.90909090909 936 5.76924110118375e-07 162 1.85441830154932 2.05717898760675 1 10.4766665026435 422 2590 1602 1372 2589 709 596 162 936 2649 804 729 M10755 GO_TRANSITION_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSPORT.html The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 46/122 Gene Ontology BP GO:0000041 1.38041652149598e-06 5.55396352626157e-06 515 1060.18181818182 937 1.25492489786885e-07 350 1.31471508197368 -1.19003093616431 -1 8.18493404843766 513 781 2273 1559 1062 350 657 903 1502 1125 937 730 M13778 GO_ADRENAL_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENAL_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 13/28 Gene Ontology BP GO:0030325 3.77083585297072e-05 7.64875092413415e-05 1080 1164.36363636364 937 3.42809135205705e-06 331 2.75361093706986 2.74416030751307 1 13.4276247243828 1080 2473 686 1560 2296 937 390 331 933 1251 871 731 M12560 GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. 145/340 Gene Ontology BP GO:0051056 3.30705754579254e-08 5.70925169633382e-07 35 1121.09090909091 940 3.00641599591318e-09 16 1.74069558570877 1.8965833078891 1 12.8742957193323 1211 34 316 33 16 3388 2362 1389 940 297 2346 732 M13260 GO_APPENDAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APPENDAGE_DEVELOPMENT.html The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. 94/288 Gene Ontology BP GO:0048736 9.79316803108794e-07 4.33044563508012e-06 665 996.454545454545 940 8.90288399132787e-08 348 2.03314522407739 2.13955845296517 1 12.9179051613036 661 880 348 773 940 1411 944 1793 1135 451 1625 733 M14599 GO_LIMB_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMB_DEVELOPMENT.html The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. 94/288 Gene Ontology BP GO:0060173 9.79316803108794e-07 4.33044563508012e-06 945 993.909090909091 941 8.90288399132787e-08 349 2.03314522407739 2.13955845296517 1 12.9179051613036 662 881 349 774 941 1412 945 1755 1136 452 1626 734 M14491 GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE.html The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. 2/15 Gene Ontology BP GO:0007342 0.000468704096471272 0.00074731906590526 885 1385.7 942 5.20890847132429e-05 325 2.59816426782652 -2.59816426782652 -1 9.62281690261989 883 1223 4244 NA 3057 668 506 722 325 1001 1228 735 M15225 GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of MAP kinase activity. 128/335 Gene Ontology BP GO:0043406 9.8453638972213e-07 4.34938387961927e-06 855 1003.45454545455 942 8.95033482107933e-08 387 1.84218821721784 1.93623020036824 1 11.7004941260669 851 1312 387 595 942 1337 1475 1597 1116 515 911 736 M10067 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. 69/164 Gene Ontology BP GO:0050680 0.000212248865377348 0.000360846386652151 705 1106.09090909091 943 1.92972132023426e-05 646 1.57497110769293 1.93871971340676 1 6.42313334175982 703 1383 925 873 2601 1204 1023 729 1137 646 943 737 M15050 GO_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 75/182 Gene Ontology BP GO:0032526 1.80062603878611e-10 5.22519168630245e-09 435 829.636363636364 943 1.63693276266681e-11 148 2.20528748926088 2.32666893333665 1 21.6358094112553 435 398 148 381 943 1525 1510 1165 1067 175 1379 738 M16757 GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 51/105 Gene Ontology BP GO:0002088 6.4651840705503e-07 3.34274494872662e-06 1475 1207.90909090909 943 5.87744179135244e-08 89 1.61910242401281 1.82826535453317 1 10.5028607268729 1472 89 929 461 771 2100 1505 2438 943 624 1955 739 M16907 GO_CORPUS_CALLOSUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORPUS_CALLOSUM_DEVELOPMENT.html The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. 18/36 Gene Ontology BP GO:0022038 1.42237076957669e-06 5.6622369552097e-06 255 1097.54545454545 945 1.29306517198725e-07 24 1.37399641735577 1.37399641735577 1 8.5403500259114 251 2916 2202 1555 1074 155 24 316 945 2452 183 740 M10768 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 27/104 Gene Ontology BP GO:0035725 5.25286697463241e-07 2.97065302840661e-06 2565 1370.36363636364 948 4.77533475349314e-08 614 1.79865223867848 -1.93848744399775 -1 11.7767740189755 2562 800 732 944 681 1483 2855 1504 948 614 1951 741 M14001 GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the Notch signaling pathway. 34/96 Gene Ontology BP GO:0008593 1.01006037363307e-06 4.44101355566129e-06 950 1753.18181818182 948 9.1823712488238e-08 277 2.2892966825946 -1.4751231161217 -1 14.5157091846157 3906 277 620 948 946 2160 3644 1026 459 941 4358 742 M12269 GO_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION.html The movement of a leukocyte within or between different tissues and organs of the body. 130/380 Gene Ontology BP GO:0050900 5.68803424239672e-14 3.07087709156372e-12 805 1137.63636363636 949 5.17094022036078e-15 80 1.95826349113014 2.03656893002845 1 26.7071660427316 803 520 80 949 574 1957 1470 2201 1846 133 1981 743 M14984 GO_POSITIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_REMODELING.html Any process that activates or increases the frequency, rate or extent of bone remodeling. 4/15 Gene Ontology BP GO:0046852 0.000112346512399962 0.000201399558715453 855 1435.27272727273 950 1.12352192586609e-05 259 2.70931324468754 -2.70931324468754 -1 11.8621209238966 855 1592 4330 2232 2481 343 300 950 259 1710 736 744 M13501 GO_POSITIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_RESORPTION.html Any process that activates or increases the frequency, rate or extent of bone resorption. 4/15 Gene Ontology BP GO:0045780 0.000112346512399962 0.000201399558715453 855 1412.18181818182 954 1.12352192586609e-05 258 2.70931324468754 -2.70931324468754 -1 11.8621209238966 854 1591 4088 2231 2480 342 299 954 258 1702 735 745 M15890 GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). 22/109 Gene Ontology BP GO:0007189 7.01779400394023e-07 3.49773175348898e-06 555 1245.54545454545 956 6.37981476595618e-08 553 2.14824086174959 2.07814481155362 1 13.8852076189262 553 1557 956 1086 806 804 930 1927 2670 1821 591 746 M12631 GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of adherens junction organization. 52/107 Gene Ontology BP GO:1903391 6.38484641231243e-05 0.000121445480919159 305 1068.63636363636 957 5.80457429185491e-06 302 1.78023828375757 1.80565130710426 1 8.25765124440619 302 1745 508 1186 2319 896 525 957 1440 550 1327 747 M10876 GO_NEGATIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. 108/243 Gene Ontology BP GO:0030308 1.56936465132046e-06 6.04192377784486e-06 520 1120.09090909091 958 1.42669615529458e-07 303 1.66890552353972 1.83382399411144 1 10.3176905169785 519 2334 958 2091 1108 520 602 371 2408 1107 303 748 M13623 GO_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that modulates the frequency, rate or extent of reproductive process. 67/184 Gene Ontology BP GO:2000241 3.69729701894911e-07 2.54323684131157e-06 2625 1725.81818181818 958 3.36117967301193e-08 100 1.9963797737512 -1.68266125486458 -1 13.2309574520441 2622 770 717 100 503 3735 2877 4280 958 870 1552 749 M16803 GO_NEUROPEPTIDE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. 18/105 Gene Ontology BP GO:0007218 6.49650740061989e-07 3.34994975016067e-06 795 974.363636363636 958 5.90591756273816e-08 484 2.6319896534507 3.0652714600676 1 17.0703852525526 792 2023 511 1306 773 1112 536 1177 1046 958 484 750 M11652 GO_BONE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_GROWTH.html The increase in size or mass of a bone that contributes to the shaping of that bone. 6/26 Gene Ontology BP GO:0098868 8.60607252153241e-05 0.000158689415081314 550 1338.36363636364 961 8.60640582987866e-06 84 1.77076187028193 1.77076187028193 1 7.97001499887713 548 1825 3783 2243 2504 276 84 1373 961 756 369 751 M12590 GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. 6/18 Gene Ontology BP GO:0002830 8.66504133409548e-06 2.19524395639853e-05 825 1288.45454545455 961 8.66507512160449e-07 340 2.19812643063869 -2.32803259463844 -1 12.1304919510992 824 340 3936 540 1747 961 1804 1319 542 759 1401 752 M12042 GO_NEGATIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COAGULATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. 24/67 Gene Ontology BP GO:0050819 2.82367055930176e-11 9.56956380061175e-10 975 874.454545454545 963 2.56697323576182e-12 127 2.13281345830984 2.17395568909659 1 22.7873867212943 429 436 127 672 1793 963 974 1909 1188 153 975 753 M10221 GO_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 75/226 Gene Ontology BP GO:0045471 3.86685259824543e-09 8.97689830682676e-08 1105 985.090909090909 965 3.51532055003823e-10 171 2.38248193868047 2.70192624218296 1 19.8885979879443 1104 965 182 171 1129 1869 1853 852 780 507 1424 754 M12106 GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY.html The disaggregation of a beta-catenin destruction complex into its constituent components. 12/34 Gene Ontology BP GO:1904886 1.05967416002884e-06 4.57862597058646e-06 475 1094.81818181818 968 9.63340609493191e-08 310 1.40369164392302 1.40369164392302 1 8.87832823092996 473 1432 1628 1189 968 448 310 914 3145 1112 424 755 M15075 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 43/162 Gene Ontology BP GO:0050806 1.02961674338751e-06 4.49016470728422e-06 2575 1639.45454545455 968 9.36015659323908e-08 410 1.92452804845196 -1.45685857578125 -1 12.1919279226212 2573 410 734 868 953 3364 2559 2678 492 968 2435 756 M16202 GO_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 72/242 Gene Ontology BP GO:0044070 5.28290908562603e-06 1.46351711721728e-05 970 1050.27272727273 968 4.80265615603286e-07 497 1.99306886034616 2.30075742366062 1 11.4146102257878 968 885 497 531 1577 1309 1152 1868 902 716 1148 757 M12263 GO_PROXIMAL_DISTAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROXIMAL_DISTAL_PATTERN_FORMATION.html The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). 18/48 Gene Ontology BP GO:0009954 1.19057596689784e-05 2.87309990348581e-05 530 1053.18181818182 970 1.08234764545206e-06 213 2.39918055379528 2.76820104983658 1 12.9078696385068 530 2271 970 1692 1898 666 1057 213 408 1342 538 758 M14992 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 742/1992 Gene Ontology BP GO:0048585 2.19684603321856e-07 1.90297689034212e-06 970 1306.36363636364 970 2.19684625039455e-08 284 1.65646945818082 1.87472144760513 1 11.2253659196194 970 864 4333 748 368 1639 1272 822 1942 284 1128 759 M12407 GO_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. 13/55 Gene Ontology BP GO:0050433 6.13976215173983e-07 3.23212152206309e-06 905 957.545454545455 971 5.58160351384175e-08 160 2.19682588385393 2.8149673176728 1 14.2884973230943 902 320 971 1202 750 1729 1515 160 270 1246 1468 760 M15546 GO_ACTIN_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 118/243 Gene Ontology BP GO:0007015 7.45266490250423e-07 3.61953170944844e-06 1125 972.363636363636 972 6.77515220650138e-08 363 1.76391176186372 1.96345397531333 1 11.3700235644856 1124 637 626 363 838 1168 972 1577 1036 850 1505 761 M14322 GO_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULOGENESIS.html The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. 48/94 Gene Ontology BP GO:0001570 1.29563933321019e-06 5.31609973410392e-06 230 1005.36363636364 976 1.17785463295251e-07 226 1.79158996020318 1.73313255081651 1 11.1941284417899 226 1080 603 1635 1043 616 483 1580 2004 813 976 762 M14116 GO_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_MIGRATION.html The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. 27/59 Gene Ontology BP GO:0008347 2.75572177804644e-06 8.91003914726297e-06 395 824.545454545455 978 2.50520475442893e-07 58 1.66568676729465 1.66317475911877 1 9.9649034500495 394 1791 1176 978 1342 192 75 1194 862 1008 58 763 M15418 GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. 25/55 Gene Ontology BP GO:2000249 3.80478594597509e-06 1.13168617214365e-05 1610 1097.63636363636 978 3.45890229651915e-07 126 1.9631808093055 1.9631808093055 1 11.5031427144454 315 2267 978 1840 1884 401 650 126 1607 1608 398 764 M15864 GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of stem cell proliferation. 32/102 Gene Ontology BP GO:2000648 3.99683890439916e-06 1.17749511631506e-05 1075 966.545454545455 983 3.63349651423141e-07 559 1.66386722627945 1.8011730660766 1 9.71536484406211 1024 559 1359 737 1482 983 659 1072 742 1075 940 765 M12079 GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. 11/37 Gene Ontology BP GO:0030320 8.69816786207818e-06 2.19965105575321e-05 495 1424.81818181818 984 7.9074565930227e-07 104 1.41655387623952 1.41655387623952 1 7.81587494141111 494 2604 2012 2815 2895 371 104 191 2644 984 559 766 M16247 GO_LIMBIC_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMBIC_SYSTEM_DEVELOPMENT.html The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. 57/180 Gene Ontology BP GO:0021761 1.1231077534525e-06 4.77526492608055e-06 985 1014.72727272727 984 1.02100756982125e-07 386 1.69988363047148 1.77562437616619 1 10.7149633674965 909 1244 1523 984 987 984 845 590 1731 979 386 767 M10238 GO_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_SECRETION.html The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. 15/54 Gene Ontology BP GO:0014047 2.63320221515893e-07 2.07508518573853e-06 2485 1518.36363636364 986 2.39382048211783e-08 82 2.77830742978549 3.27196905888544 1 18.7039474313114 2485 317 926 638 398 4012 3840 986 82 1470 1548 768 M11609 GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 448/1229 Gene Ontology BP GO:1901701 4.24295885608284e-14 2.3735009600955e-12 990 1074.36363636364 986 3.85723532371173e-15 8 1.71314054435277 1.82946624357488 1 23.5911698618143 986 8 77 585 255 2300 2160 1908 1930 140 1469 769 M14261 GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 13/37 Gene Ontology BP GO:0009190 0.000105946562882826 0.000191181458012033 130 1249.18181818182 986 9.63196957740645e-06 113 1.57078398736364 1.57078398736364 1 6.91940229132108 128 841 986 1677 2446 201 113 1142 3888 1848 471 770 M13241 GO_CELLULAR_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions at the level of a cell. 11/37 Gene Ontology BP GO:0030002 1.44542176071582e-05 3.37410419054981e-05 495 1429.81818181818 987 1.31402841578828e-06 105 1.41655387623952 1.41655387623952 1 7.50408084439287 495 2605 2013 2816 2896 372 105 234 2645 987 560 771 M13871 GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that activates or increases the frequency, rate, or extent of tissue remodeling. 11/31 Gene Ontology BP GO:0034105 2.55852125494782e-05 5.49709124790502e-05 395 1086.81818181818 988 2.32595546374427e-06 111 1.66331500541173 -1.66331500541173 -1 8.39360573337428 392 1768 1762 2191 2031 162 111 1147 759 988 644 772 M15104 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION.html The process in which epiblast cells acquire specialized features of neuroepithelial cells. 33/104 Gene Ontology BP GO:0060563 4.43097991226129e-07 2.74343418554066e-06 2370 1540 988 4.02816436790649e-08 83 2.07776767057642 2.25991683468753 1 13.6893560040147 2370 988 455 83 598 3496 3575 2351 282 561 2181 773 M14165 GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION.html Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. 24/46 Gene Ontology BP GO:0070570 3.35087528354717e-07 2.39728491551567e-06 710 1065.18181818182 989 3.04625072175228e-08 470 1.76510286369419 1.98789921085275 1 11.7518445574677 710 1479 989 889 470 1298 1736 1349 880 1122 795 774 M14432 GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is increased. 14/50 Gene Ontology BP GO:0045777 0.000215331973081687 0.000365285477171455 870 1399.90909090909 989 1.95775502063264e-05 509 2.22309033077023 2.51757901694402 1 9.0523452444574 868 2861 1338 1951 3596 989 717 565 509 1397 608 775 M14290 GO_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. 17/63 Gene Ontology BP GO:0006939 1.15982132954182e-05 2.80617531686433e-05 945 1090.36363636364 990 1.05438858551506e-06 353 3.40277793051265 4.46309869873579 1 18.3486015463162 945 1489 481 657 1795 990 1567 1067 353 1799 851 776 M11938 GO_RESPONSE_TO_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METAL_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 199/517 Gene Ontology BP GO:0010038 4.8236028681543e-15 3.11055390511672e-13 1420 927 991 4.38509351650391e-16 67 2.01514256224977 2.25642469290163 1 29.856757280797 1417 511 67 200 131 2446 1923 1025 991 112 1374 777 M13949 GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY.html The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. 7/43 Gene Ontology BP GO:0060397 0.00100656429971856 0.00150854681846135 860 1640 992 0.000100702051784049 582 1.87083836224805 -1.87083836224805 -1 6.25295432578263 859 1722 4163 1964 2945 590 582 912 992 2391 920 778 M12571 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. 11/32 Gene Ontology BP GO:0006359 5.8945847176896e-07 3.20474904499213e-06 1405 1309.27272727273 993 5.35871481550881e-08 79 3.97916693679371 3.97916693679371 1 25.898533298288 1403 328 1781 875 725 2489 2137 663 79 2929 993 779 M16873 GO_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_FUSION.html A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 11/49 Gene Ontology BP GO:0007520 9.44815283048565e-06 2.35468457283655e-05 1595 1152.63636363636 993 8.58926673355251e-07 645 2.75943023623686 3.66769088753899 1 15.1285440527455 1593 707 645 646 1741 1948 1029 921 799 993 1657 780 M13803 GO_COENZYME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 76/138 Gene Ontology BP GO:0009108 1.14346911264541e-06 4.84156232568531e-06 375 1448 995 1.03951791543078e-07 125 1.12866899327401 -0.982472248965256 -1 7.10639010936447 328 887 3109 2464 995 125 374 1624 2029 3619 374 781 M15174 GO_VISUAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VISUAL_BEHAVIOR.html The behavior of an organism in response to a visual stimulus. 26/78 Gene Ontology BP GO:0007632 1.16516662486445e-06 4.91258112276232e-06 1030 1092.90909090909 995 1.05924294723804e-07 247 1.4491952877058 1.23213433798904 1 9.113649495631 1027 913 2217 885 1001 538 247 995 919 2211 1069 782 M15812 GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE.html Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. 7/23 Gene Ontology BP GO:0051969 2.39426132375792e-05 5.19708056391212e-05 260 1121.45454545455 995 2.39428712034188e-06 106 2.6743855165656 2.6743855165656 1 13.5730018100405 259 1034 4461 1095 2042 157 106 358 995 1515 314 783 M11627 GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. 14/44 Gene Ontology BP GO:0045746 3.44174804747488e-07 2.44717246315863e-06 3690 1677.36363636364 996 3.12886235082973e-08 463 2.63945052542992 -1.70033882717394 -1 17.5451795014657 3688 463 635 864 477 2288 2337 996 939 1386 4378 784 M12649 GO_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASOCONSTRICTION.html A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. 14/39 Gene Ontology BP GO:0042310 6.25174534197852e-05 0.000119304782666692 540 1205.09090909091 996 5.68356636822351e-06 538 3.40296671517808 3.40296671517808 1 15.8158282572882 538 1856 695 1326 2313 686 996 1785 683 1388 990 785 M16390 GO_EPITHELIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. 7/23 Gene Ontology BP GO:0072148 2.07797566851236e-06 7.35368980861499e-06 1710 1541 996 2.07797761160721e-07 75 2.47037963093543 3.0671270605586 1 15.0229377693322 1706 480 4557 75 1262 3267 3258 475 294 581 996 786 M16935 GO_ACTIVATION_OF_MAPKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). 27/76 Gene Ontology BP GO:0000186 1.14391425183648e-06 4.84156232568531e-06 880 946.363636363636 996 1.0399225878434e-07 369 1.43377220206366 1.57353122546095 1 9.02739879419706 877 1166 1593 959 996 891 1061 1028 369 1010 460 787 M12531 GO_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 26/57 Gene Ontology BP GO:0034333 4.12465495603114e-07 2.61980478260637e-06 1000 1063.27272727273 997 3.74968702667223e-08 271 2.06016374730015 2.53183992615445 1 13.6222453095887 997 678 1043 271 573 1968 1621 1375 568 1720 882 788 M16239 GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. 365/1026 Gene Ontology BP GO:0045596 3.95135346905032e-14 2.23733343375618e-12 1015 927.818181818182 999 3.59213951731853e-15 76 1.84363676220496 2.03176274758006 1 25.4442348950703 1014 503 76 264 592 1952 1607 999 1579 158 1462 789 M10215 GO_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 463/1225 Gene Ontology BP GO:1901698 5.93981099165141e-12 2.17153877434941e-10 1000 946.727272727273 1000 5.39982817424313e-13 118 1.70622529918502 1.86701225197542 1 19.5315570459372 1000 202 118 361 407 1705 1747 1691 1729 198 1256 790 M15319 GO_PROTEIN_HOMOTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTRIMERIZATION.html The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. 13/23 Gene Ontology BP GO:0070207 0.000101148550052322 0.000183378648142496 690 1151.27272727273 1000 9.19574552904457e-06 195 1.86252632778088 -1.96100948158066 -1 8.24447485216297 688 1569 1519 1780 2437 203 195 1729 1000 861 683 791 M15960 GO_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REPOLARIZATION.html The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. 11/28 Gene Ontology BP GO:0086009 3.94193996771399e-07 2.59241179463117e-06 1955 1121 1000 3.58358243093397e-08 544 1.81417382620094 1.73522279331225 1 12.0055174263854 1952 706 1000 858 544 1689 1281 1872 660 665 1104 792 M13320 GO_RENAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_WATER_HOMEOSTASIS.html Renal process involved in the maintenance of an internal steady state of water in the body. 19/53 Gene Ontology BP GO:0003091 2.09107622685632e-06 7.38316876144023e-06 305 1134.09090909091 1002 1.90098019491302e-07 114 1.82610128659097 1.82610128659097 1 11.1011762796084 301 1002 1080 1519 1226 291 114 970 3061 2559 352 793 M10373 GO_CARDIAC_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_DEVELOPMENT.html The progression of a cardiac septum over time, from its initial formation to the mature structure. 56/145 Gene Ontology BP GO:0003279 4.53728145748356e-07 2.77810178434719e-06 625 993.363636363636 1004 4.1248021756846e-08 608 1.6054260974666 1.67743916174794 1 10.5669651153325 625 1079 1004 1500 608 758 1073 1109 1854 639 678 794 M15095 GO_RESPIRATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_DEVELOPMENT.html The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. 114/307 Gene Ontology BP GO:0060541 4.20256903885819e-08 6.65956588649098e-07 75 1150.09090909091 1004 3.82051738103467e-09 73 1.73785713844769 1.63033418454002 1 12.715644123886 1004 385 233 783 73 1509 1618 3938 1785 74 1249 795 M15924 GO_MODULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 138/448 Gene Ontology BP GO:0050804 5.99223583127754e-07 3.22760452025773e-06 895 984.272727272727 1005 5.44748860309958e-08 510 1.83968432028276 1.92361744720267 1 11.9669164036879 893 1233 510 552 735 1029 1005 1722 1124 530 1494 796 M14525 GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. 27/57 Gene Ontology BP GO:0048635 1.76043266317602e-05 4.00082665449156e-05 1330 1060.54545454545 1009 1.60040613659754e-06 458 1.96525900582915 2.33057383680279 1 10.2385454890217 1330 1328 1298 565 1924 1467 674 458 722 1009 891 797 M14419 GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/49 Gene Ontology BP GO:0032369 1.49274286271051e-05 3.4714989797606e-05 575 1075.36363636364 1011 1.35704817396171e-06 498 1.77753426202349 1.95872170959021 1 9.39032261099914 575 1188 1557 1011 1871 742 651 1068 645 2023 498 798 M10935 GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 15/26 Gene Ontology BP GO:0071498 2.44603188521493e-06 8.19994660148226e-06 1305 1079.45454545455 1013 2.22366782254303e-07 240 1.93464283799145 2.03845474682795 1 11.6565848995368 1302 314 724 366 1294 2414 2554 382 240 1013 1271 799 M15832 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of endothelial cell proliferation. 44/103 Gene Ontology BP GO:0001938 2.15198363462516e-07 1.88521887086125e-06 1090 1174.45454545455 1013 1.9563489501152e-08 327 1.81041148849004 1.7485882574014 1 12.2773146113237 1090 1472 632 1502 327 1013 903 1873 2356 822 929 800 M11421 GO_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXON_GUIDANCE.html Any process that modulates the frequency, rate or extent of axon guidance. 15/47 Gene Ontology BP GO:1902667 0.000433156768855436 0.000693977528569975 375 1360.45454545455 1015 3.938564330589e-05 375 1.89686067764133 1.95706783290773 1 7.09766617865283 375 1934 553 1081 3141 943 807 1547 2581 1015 988 801 M12727 GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 36/61 Gene Ontology BP GO:0010660 1.45068168584653e-06 5.73723600288368e-06 1530 1015.63636363636 1015 1.3188024022073e-07 397 2.12508931171352 2.11434571374738 1 13.1945330943756 1527 903 551 397 1082 1462 1285 1725 1015 658 567 802 M13216 GO_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. 39/90 Gene Ontology BP GO:0048546 2.28406352605272e-06 7.83227987552643e-06 1265 1051.63636363636 1015 2.07642354308668e-07 620 1.9567879735251 2.34719426989673 1 11.8361955106028 620 1618 1011 739 1261 1015 635 1132 1264 1263 1010 803 M12585 GO_CEREBELLAR_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 34/95 Gene Ontology BP GO:0021695 1.20083677586457e-06 4.9965450210294e-06 425 1526.09090909091 1016 1.09167039211245e-07 423 2.31249527837068 -1.54031117671865 -1 14.5225794565565 2733 1622 547 429 1016 3337 2806 423 423 940 2511 804 M11019 GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein oligomerization. 17/43 Gene Ontology BP GO:0032459 2.4140454675154e-07 1.98730728824007e-06 370 1206.18181818182 1017 2.19458702946095e-08 366 2.07735701208057 -1.91268353109435 -1 14.0312452824174 1738 462 1064 1017 367 708 1217 3797 366 1790 742 805 M10259 GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING.html The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. 301/794 Gene Ontology BP GO:0009792 6.22015693274447e-08 9.03669098023403e-07 700 879.545454545455 1018 5.65468828055428e-09 54 1.66976114061796 1.79136285565481 1 11.9551813476056 700 626 288 1018 54 1203 1070 1127 1867 526 1196 806 M13963 GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. 15/29 Gene Ontology BP GO:0045683 2.49738004190771e-06 8.3419680104874e-06 2755 1474.54545454545 1018 2.27034806988179e-07 39 2.99163616089937 -1.57106605216834 -1 17.9987393096788 2754 698 868 227 1300 3901 3446 101 39 1018 1868 807 M10832 GO_ADULT_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_BEHAVIOR.html Behavior in a fully developed and mature organism. 56/246 Gene Ontology BP GO:0030534 2.34814630558352e-07 1.96311268848144e-06 1055 1047.27272727273 1019 2.13467868746402e-08 263 1.75603268013952 1.95614119310059 1 11.8719668303073 1053 263 867 1019 356 1119 977 1262 1877 640 2087 808 M14454 GO_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_POTENTIATION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. 15/63 Gene Ontology BP GO:0060291 2.36051267099246e-06 7.97893949495477e-06 875 1029.09090909091 1021 2.14592291248424e-07 153 1.70755600930874 1.83381607373197 1 10.3123463441242 872 153 1355 1230 1282 956 1236 1853 456 1021 906 809 M11051 GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type peptidase activity. 2/15 Gene Ontology BP GO:1902571 9.59416659278285e-05 0.000174418769979254 1230 1425.1 1022.5 1.06606396887385e-05 12 2.87307493963776 -2.87307493963776 -1 12.7917152000594 1230 1045 3676 NA 3005 798 723 476 12 2286 1000 810 M11683 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. 2/12 Gene Ontology BP GO:1902572 9.4771288709441e-05 0.000172965052467742 1235 1436.9 1023.5 1.05305867520682e-05 13 2.87307493963776 -2.87307493963776 -1 12.8040864143642 1231 1046 3789 NA 3006 799 724 471 13 2289 1001 811 M13174 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. 2/12 Gene Ontology BP GO:1900004 9.49437859700945e-05 0.000173075774738574 1235 1461.9 1024.5 1.05497547305736e-05 14 2.87307493963776 -2.87307493963776 -1 12.8031405104552 1232 1047 4028 NA 3007 800 725 472 14 2292 1002 812 M13099 GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 9/22 Gene Ontology BP GO:0009068 2.64802599895513e-07 2.0803358228678e-06 1085 1100.90909090909 1025 2.64802631449706e-08 32 1.55579097647043 -1.5950885950649 -1 10.4717751773046 1081 848 4012 1035 1025 695 1223 32 741 1198 220 813 M15052 GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. 2/15 Gene Ontology BP GO:1900003 9.57440506059346e-05 0.000174192643794418 1235 1494.2 1025.5 1.0638680559962e-05 15 2.87307493963776 -2.87307493963776 -1 12.7936327588015 1233 1048 4339 NA 3008 801 726 474 15 2295 1003 814 M11578 GO_ADULT_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_LOCOMOTORY_BEHAVIOR.html Locomotory behavior in a fully developed and mature organism. 40/161 Gene Ontology BP GO:0008344 3.93231519443318e-07 2.58975027627706e-06 755 963.909090909091 1026 3.5748326339106e-08 275 1.79420725932593 1.92956436328476 1 11.8743343709794 752 275 1445 1183 542 646 701 1082 1742 1026 1209 815 M10216 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 51/133 Gene Ontology BP GO:0034763 2.95762381178322e-07 2.21487860614669e-06 1005 1433.54545454545 1028 2.68874928127154e-08 432 1.29547703883023 1.32327029213514 1 8.67787663592796 1003 777 2169 1050 432 1028 908 3676 2205 928 1593 816 M10490 GO_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 37/113 Gene Ontology BP GO:0001656 1.24447076829175e-06 5.15439587616289e-06 1945 1334 1029 1.13133770204569e-07 274 2.01930446357995 2.17990645710098 1 12.6490146449442 1945 274 436 422 1029 2453 1962 2694 330 693 2436 817 M11055 GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. 13/34 Gene Ontology BP GO:0002042 1.29958083785815e-05 3.0880009366302e-05 165 943.454545454545 1029 1.18144410435172e-06 62 1.56585476831234 1.56585476831234 1 8.36637057565412 163 1644 1493 1029 1833 160 62 346 2236 1244 168 818 M14531 GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. 8/25 Gene Ontology BP GO:0035590 8.33902124310003e-05 0.000154071132637141 725 1662 1030 8.33933418636671e-06 559 2.46231791945969 2.46231791945969 1 11.1200517174306 725 2611 4248 2697 2410 665 559 1030 841 1749 747 819 M16275 GO_REGULATION_OF_CELL_PROJECTION_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_SIZE.html A process that modulates the size of a cell projection. 7/27 Gene Ontology BP GO:0032536 1.42953526726952e-06 5.6804125365022e-06 1385 1360.72727272727 1030 1.42953618687733e-07 65 2.11078680772665 -2.6059745564272 -1 13.1165389682871 1385 1030 4540 863 2085 976 1916 77 65 1518 513 820 M16741 GO_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 177/422 Gene Ontology BP GO:0009100 4.6044860640551e-07 2.78730492769333e-06 1035 1243 1031 4.18589729795496e-08 618 1.52504709614875 1.68544272640804 1 10.0353130455662 1031 748 1793 2265 618 1338 1010 963 1920 949 1038 821 M11158 GO_L_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSPORT.html The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/67 Gene Ontology BP GO:0015807 1.09311400644055e-06 4.67828054520338e-06 2345 1529.54545454545 1032 9.93740499614987e-08 618 2.07803489798604 2.28782059894228 1 13.1205204645277 2345 1180 996 1032 978 3588 2918 738 618 780 1652 822 M10877 GO_MODIFIED_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSPORT.html The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/36 Gene Ontology BP GO:0072337 5.3547960180133e-06 1.48166376112251e-05 2235 1132.54545454545 1033 4.86800822874685e-07 151 2.08456588780189 -2.69892651812586 -1 11.9254118402889 2231 322 975 1033 1642 1258 2526 151 411 539 1370 823 M11334 GO_TISSUE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. 109/311 Gene Ontology BP GO:0001894 3.75687646527125e-06 1.12474942512075e-05 740 920.636363636364 1035 3.41534807345094e-07 387 2.07505500554871 2.22090309167434 1 12.1652269107911 740 387 461 769 1457 1060 1035 1093 1096 871 1158 824 M14281 GO_MESODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. 18/48 Gene Ontology BP GO:0048333 1.26184976945944e-06 5.20779420408907e-06 345 1182.90909090909 1035 1.14713681201525e-07 344 1.99885745495483 1.99885745495483 1 12.510334900941 344 2273 1970 1409 1035 422 486 637 1646 2446 344 825 M11393 GO_NEURAL_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. 102/237 Gene Ontology BP GO:0021915 4.42172758790549e-08 6.93583824008284e-07 960 976.090909090909 1036 4.01975243343341e-09 34 1.45749334259075 1.50847313704954 1 10.6337841115651 958 54 1195 396 34 1390 1036 2343 1711 531 1089 826 M14244 GO_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 21/61 Gene Ontology BP GO:0009268 5.8344755260151e-08 8.59983170390098e-07 2715 1764.09090909091 1036 5.30406880067946e-09 49 1.7274337490329 1.49684908394527 1 12.4121429732614 2713 449 691 1036 49 3521 2748 2971 899 377 3951 827 M10875 GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. 19/37 Gene Ontology BP GO:0032793 1.30410802425755e-06 5.32539450890749e-06 105 1003.72727272727 1037 1.18555345209329e-07 6 1.28547371618298 1.28547371618298 1 8.03068087306917 104 1976 1820 1554 2008 70 6 350 1864 1037 252 828 M10927 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. 47/145 Gene Ontology BP GO:0048704 4.0838493066941e-07 2.61980478260637e-06 565 950.272727272727 1037 3.71259096797932e-08 266 2.03201378123227 2.25325561204204 1 13.4361116631363 562 266 289 450 1289 1643 1275 1462 1037 524 1656 829 M10632 GO_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 32/93 Gene Ontology BP GO:0061035 1.27871432400558e-06 5.26803070661748e-06 1110 1252.63636363636 1039 1.16246824294377e-07 331 1.85802246279305 1.94766167034437 1 11.6178916882509 1109 1397 1142 331 1039 1197 984 4153 703 848 876 830 M11993 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 15/33 Gene Ontology BP GO:0044253 1.08390827230788e-05 2.64316497286003e-05 980 1230.36363636364 1040 9.85376011458598e-07 426 2.03010313860901 2.3902295647837 1 11.0093109228158 980 1564 722 426 1779 1759 2355 1355 538 1016 1040 831 M12534 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/43 Gene Ontology BP GO:0043267 5.56910878522725e-07 3.09534389000729e-06 1375 1316.09090909091 1040 5.0628274499993e-08 571 1.50713275517043 1.66597653380548 1 9.83615255456647 1371 819 1260 762 705 1040 1109 3228 2677 571 935 832 M14949 GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS.html The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. 19/37 Gene Ontology BP GO:0046716 2.43581649650026e-08 4.41777187236356e-07 1580 1022.27272727273 1040 2.21437865769942e-09 13 1.69862789461277 1.78498173001343 1 12.7872736303737 1577 577 1413 437 13 2116 1503 924 429 1040 1216 833 M15830 GO_POST_ANAL_TAIL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_ANAL_TAIL_MORPHOGENESIS.html The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. 18/44 Gene Ontology BP GO:0036342 1.2869912741282e-06 5.2880535272365e-06 760 953.636363636364 1041 1.16999275183055e-07 274 2.52534290646826 2.72328793855333 1 15.7856023635207 758 1636 1167 817 1041 1082 353 863 274 1349 1150 834 M16187 GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. 15/33 Gene Ontology BP GO:0010714 1.08390827230788e-05 2.64316497286003e-05 985 1233.36363636364 1041 9.85376011458598e-07 427 2.03010313860901 2.3902295647837 1 11.0093109228158 981 1565 723 427 1780 1760 2356 1372 539 1023 1041 835 M10947 GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 137/324 Gene Ontology BP GO:0031668 1.07879906511386e-06 4.63668460806044e-06 1045 1305.90909090909 1042 9.80726903743273e-08 402 1.89129325885147 2.11679191498044 1 11.9501409287156 1042 2772 402 2020 972 1227 1863 849 1678 719 821 836 M10499 GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the rate of skeletal muscle tissue development. 14/40 Gene Ontology BP GO:0048643 1.63271960727969e-06 6.18186332649014e-06 930 1302.45454545455 1043 1.48429165363282e-07 82 1.95518020666395 2.18393924151462 1 12.0644974417364 927 2225 961 1184 2650 998 1043 82 1913 1998 346 837 M15259 GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/16 Gene Ontology BP GO:0032372 3.31230008759899e-05 6.8108987186546e-05 640 1314.72727272727 1043 3.31234945962812e-06 17 2.6981533162725 2.6981533162725 1 13.3182408716607 636 857 4377 252 2156 1541 1947 1043 17 1095 541 838 M12446 GO_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that modulates the activity of a transporter. 105/288 Gene Ontology BP GO:0032409 3.30967159349364e-07 2.38245041993658e-06 1075 1066.09090909091 1044 3.00879281036315e-08 47 1.54693529643517 1.72599400281359 1 10.3042507713723 1075 47 629 687 466 1044 1279 2522 1990 585 1403 839 M12632 GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. 361/914 Gene Ontology BP GO:0007167 4.08339235574396e-10 1.12184560400705e-08 810 873.545454545455 1045 3.71217486954716e-11 157 1.71325278279155 1.86748914479607 1 16.1350489053969 809 1139 157 673 445 1257 1495 1085 1291 213 1045 840 M13300 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 491/1400 Gene Ontology BP GO:0014070 1.81405320219461e-23 5.61509934519306e-21 1050 935.181818181818 1046 1.64913927472237e-24 14 1.83180652220157 1.99672682862419 1 43.9436871400913 1046 622 14 246 715 1446 1781 1739 1518 21 1139 841 M14849 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. 161/358 Gene Ontology BP GO:2000116 2.32754000641595e-06 7.90641892677468e-06 725 1215.09090909091 1047 2.11594769899405e-07 239 1.7576445126015 1.97646284115692 1 10.6230994544709 722 3332 966 2025 1276 544 1107 295 1813 1047 239 842 M16926 GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 18/56 Gene Ontology BP GO:0002312 3.16042564531489e-07 2.31084350727512e-06 1950 1278.27272727273 1047 2.87311463575289e-08 451 1.49585424622651 -1.19284931259463 -1 9.98748116015897 1948 1977 2152 1185 451 497 548 1047 462 3026 768 843 M11325 GO_MATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING.html The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. 13/48 Gene Ontology BP GO:0007618 2.31830785288706e-06 7.89630384264878e-06 1610 1136.27272727273 1048 2.10755481442594e-07 452 2.3160258859635 2.43579835739732 1 13.999449340175 1607 468 883 1201 1273 1048 987 1723 452 858 1999 844 M14755 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic hydroxy compound. 83/247 Gene Ontology BP GO:1901617 1.30789797496709e-06 5.32681605067737e-06 1155 1115.27272727273 1049 1.18899886591989e-07 528 1.61906851371067 -1.48350847641889 -1 10.1145104382373 1151 528 789 1598 1049 625 1404 716 2033 927 1448 845 M10247 GO_LENS_FIBER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. 23/49 Gene Ontology BP GO:0070306 4.96397429698911e-05 9.75358978456218e-05 1045 1170.27272727273 1050 4.51280573205304e-06 264 2.21258226375213 2.28577375491559 1 10.5126525431917 1308 1927 1045 464 2244 1378 1044 1553 264 596 1050 846 M10691 GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION.html A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. 8/20 Gene Ontology BP GO:0060231 3.67955392812038e-07 2.54228703694389e-06 4435 1931.54545454545 1050 3.67955453738079e-08 171 1.99314542140048 -2.34450851693191 -1 13.2099048867274 4431 171 3618 313 559 4137 2506 1050 569 662 3231 847 M14612 GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. 44/143 Gene Ontology BP GO:0002688 7.61790763947892e-06 1.97408945586421e-05 840 1213.45454545455 1051 6.92539456183957e-07 286 1.67144838066521 1.69516674521076 1 9.31529812279503 836 1786 592 1227 1680 997 1051 736 2755 286 1402 848 M12805 GO_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. 50/169 Gene Ontology BP GO:0030216 3.89055585212778e-07 2.57804519639595e-06 1760 1033.90909090909 1052 3.53686958195206e-08 163 2.36192167249806 2.76832539026558 1 15.6370591767758 1757 1389 375 163 527 2631 1839 1089 221 330 1052 849 M11202 GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/16 Gene Ontology BP GO:0032375 3.31230008759899e-05 6.8108987186546e-05 635 1253.36363636364 1054 3.31234945962812e-06 16 2.6981533162725 2.6981533162725 1 13.3182408716607 635 856 3708 251 2155 1540 1946 1054 16 1086 540 850 M15836 GO_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that modulates the frequency, rate or extent of viral genome replication. 54/138 Gene Ontology BP GO:0045069 8.92533162570121e-07 4.08278962937248e-06 975 1808.45454545455 1055 8.11394113334779e-08 466 1.33215324269086 -1.33533407576481 -1 8.50440336641018 972 3203 2001 4068 900 466 1055 1000 3332 1958 938 851 M16676 GO_STABILIZATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_STABILIZATION_OF_MEMBRANE_POTENTIAL.html The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 5/16 Gene Ontology BP GO:0030322 1.57276639906571e-05 3.63301213475727e-05 885 1430.27272727273 1055 1.57277753035025e-06 118 2.32630826184276 -2.21019403955111 -1 12.2349492664089 1739 487 4603 516 1919 1055 885 881 118 1098 2432 852 M14745 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 6/16 Gene Ontology BP GO:0034375 6.85348659765328e-06 1.80287468968296e-05 415 1206.54545454545 1056 6.85350773437036e-07 90 1.95410254555013 1.95410254555013 1 10.9817921712146 411 1589 4285 1121 1981 327 174 927 1056 1311 90 853 M14403 GO_POTASSIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_IMPORT.html The directed movement of potassium ions into a cell or organelle. 12/35 Gene Ontology BP GO:0010107 2.53051896181913e-06 8.44235570072336e-06 1065 1341.27272727273 1062 2.30047442956141e-07 447 1.53676592546473 1.23556704451797 1 9.23626790740757 1062 702 1666 1647 1302 667 447 4135 1002 740 1384 854 M14584 GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. 189/605 Gene Ontology BP GO:0051346 1.50964313858764e-07 1.53712129220667e-06 1255 934.272727272727 1062 1.37240294743598e-08 214 1.74267742864368 1.87886018797822 1 12.000992785135 1254 1062 377 857 214 1101 1375 1005 1406 453 1173 855 M16250 GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that increases the frequency, rate, or extent of monocyte chemotaxis. 8/23 Gene Ontology BP GO:0090026 2.0091002667626e-05 4.45475288375298e-05 1065 1640.27272727273 1062 2.00911843117119e-06 276 1.77210174656565 1.77210174656565 1 9.1342598846294 416 2117 4535 2204 2570 542 346 276 2914 1062 1061 856 M12916 GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. 95/216 Gene Ontology BP GO:0071559 3.73335905423497e-06 1.12049037419605e-05 805 1193.72727272727 1070 3.39396853608259e-07 407 2.06728270160197 2.22030032300683 1 12.1236959541057 801 2181 407 980 1454 1511 986 1426 1070 560 1755 857 M13394 GO_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/158 Gene Ontology BP GO:0006865 8.23568603984016e-07 3.83930494928787e-06 2310 1591.63636363636 1071 7.48699011169602e-08 438 2.06247423867656 2.21539185443052 1 13.231984344102 2306 895 556 1071 875 4010 2662 2389 610 438 1696 858 M16391 GO_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSPORT.html The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 43/164 Gene Ontology BP GO:0006814 7.98024155847243e-07 3.78470495975357e-06 3230 1566.54545454545 1073 7.25476768473889e-08 409 1.78401292257953 -2.00632432233069 -1 11.4586375272008 3229 975 756 1073 861 1569 3059 2027 1021 409 2253 859 M13613 GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. 11/24 Gene Ontology BP GO:0070884 2.84807776367372e-05 5.99173948635013e-05 720 1241.72727272727 1074 2.5891951227363e-06 615 2.57186609861609 3.04371071453936 1 12.8644319404259 716 2518 1074 1248 2079 930 784 1361 615 1541 793 860 M13777 GO_LONG_TERM_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_MEMORY.html The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. 14/45 Gene Ontology BP GO:0007616 4.65680113578426e-07 2.80251696730727e-06 1900 1120.18181818182 1075 4.23345647409327e-08 194 2.098730636324 2.07764168526005 1 13.8044638626686 1900 588 1311 551 625 1488 989 2208 194 1393 1075 861 M10810 GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 530/1413 Gene Ontology BP GO:0045937 1.52857172073478e-07 1.53951377426715e-06 935 1299.54545454545 1076 1.5285718258787e-08 107 1.56980745405047 1.68780456639613 1 10.8092630433512 932 866 3641 581 245 1850 1777 1076 2053 107 1167 862 M11600 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/67 Gene Ontology BP GO:0043268 1.71714190763438e-07 1.64715754041078e-06 820 1367.18181818182 1076 1.56103821969145e-08 252 1.23299439136628 1.23879804825537 1 8.44718875651327 949 284 1677 1439 252 820 816 3866 2760 1100 1076 863 M10515 GO_NEURON_PROJECTION_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION.html Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 29/84 Gene Ontology BP GO:1990138 0.000445601069069084 0.000712440001269889 795 1353.63636363636 1078 4.05173953961824e-05 563 1.64525329790566 1.80065831093499 1 6.13397822571032 795 563 1069 1395 2754 992 791 1078 2347 1561 1545 864 M12447 GO_EATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EATING_BEHAVIOR.html The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. 11/46 Gene Ontology BP GO:0042755 8.78855562207851e-05 0.000161541028318727 740 1270 1078 7.9899152061455e-06 393 2.31426662084165 2.67901612551717 1 10.3950685244835 739 1433 1078 2269 2400 769 393 845 1616 1536 892 865 M15883 GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 9/22 Gene Ontology BP GO:0043649 4.01829294854247e-06 1.18306494356897e-05 1075 1396.36363636364 1078 4.01830021456617e-07 168 1.09399180396985 -0.933324432335043 -1 6.3851905335841 1073 168 4472 1078 1518 551 564 2120 599 1929 1288 866 M16100 GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. 54/119 Gene Ontology BP GO:0032273 1.43361207900746e-06 5.68911186566806e-06 2865 2043.36363636364 1078 1.30328455746358e-07 268 1.77358484902357 1.91806533301886 1 11.0197518667232 2861 655 995 268 1078 4036 3021 4482 743 1066 3272 867 M13605 GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 10/20 Gene Ontology BP GO:0036109 8.73174333442093e-05 0.000160560333868184 1050 1819.90909090909 1081 7.93826355847539e-06 264 0.696190991208641 -0.696190991208641 -1 3.12928414455292 1050 605 3112 2501 2858 375 264 1081 3405 4425 343 868 M13935 GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 41/88 Gene Ontology BP GO:0043535 2.69908133774882e-06 8.77773743407253e-06 455 1113.54545454545 1081 2.45371331739669e-07 453 1.64854142409361 1.71308201045352 1 9.87502009647508 453 2542 1360 1341 1333 629 682 780 1249 1081 799 869 M14567 GO_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 46/134 Gene Ontology BP GO:0072091 5.91786097935774e-07 3.20988651018201e-06 1250 1003.54545454545 1081 5.37987506475049e-08 408 1.58695209404109 1.86441087730346 1 10.3274188850715 1247 408 1305 615 728 1524 1081 559 1458 1127 987 870 M16847 GO_INNER_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. 59/188 Gene Ontology BP GO:0042472 8.24697300926794e-08 1.08928103117624e-06 780 956.818181818182 1081 7.49724847128726e-09 231 1.85388788237882 2.00273181582676 1 13.0953204031451 777 402 253 390 1081 1873 1637 1134 1211 231 1536 871 M12187 GO_DIGESTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 94/259 Gene Ontology BP GO:0055123 8.06096770882704e-07 3.79970284995776e-06 1085 1100.36363636364 1083 7.32815514766234e-08 309 1.94039592543756 2.32451086970049 1 12.4591307772803 1083 763 309 404 866 1718 1430 1555 1544 390 2042 872 M12509 GO_PROTEIN_TRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRIMERIZATION.html The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. 30/65 Gene Ontology BP GO:0070206 1.45242803548999e-06 5.73925393087663e-06 2150 1706.54545454545 1083 1.32038999488724e-07 111 2.1667338070831 2.33892495873059 1 13.4527089216535 2147 111 542 922 1083 4363 4125 2177 484 268 2550 873 M12932 GO_TISSUE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MIGRATION.html The process in which the population of cells that make up a tissue undergo directed movement. 62/181 Gene Ontology BP GO:0090130 1.31826952842258e-06 5.36435181460651e-06 500 1146.36363636364 1083 1.19842756213458e-07 411 2.19959644331826 2.5127480804687 1 13.7331907798792 500 2749 411 1701 1050 752 663 1083 1362 1227 1112 874 M12976 GO_REGULATION_OF_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METAL_ION_TRANSPORT.html Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 174/505 Gene Ontology BP GO:0010959 2.29246010548963e-07 1.93916799831772e-06 1060 1347.45454545455 1083 2.08405485851843e-08 215 1.55578205152513 1.64972464039318 1 10.527959998541 1058 374 397 1083 346 1468 1690 3795 2447 215 1949 875 M13536 GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. 26/46 Gene Ontology BP GO:0070830 3.00810056088466e-06 9.51404012546832e-06 2765 1456.81818181818 1085 2.73464061265808e-07 482 1.87088502215949 -2.19344679109397 -1 11.1293622534473 2764 1169 700 785 1377 2256 4103 584 482 720 1085 876 M12946 GO_RESPONSE_TO_AMPHETAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMPHETAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. 17/46 Gene Ontology BP GO:0001975 2.35174056974864e-06 7.96435555459002e-06 920 1337.54545454545 1086 2.13794825790867e-07 98 2.42954328362124 2.21757385359257 1 14.674890655175 919 2954 1693 1021 2169 1282 936 98 229 2326 1086 877 M16268 GO_NEGATIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DEATH.html Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. 114/276 Gene Ontology BP GO:1901215 1.46537796201138e-06 5.76656072488019e-06 1265 1057.63636363636 1086 1.33216267097505e-07 192 1.67781414660963 2.07749673272162 1 10.4130312799613 1264 241 908 192 1086 1379 1369 449 1517 2274 955 878 M15138 GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. 20/55 Gene Ontology BP GO:0002053 8.08376488904289e-06 2.07364200993515e-05 580 1129.72727272727 1087 7.34890417499393e-07 580 1.64947192703703 1.8115635668525 1 9.15106828512943 1221 580 1562 777 1694 1079 580 1087 595 2141 1111 879 M12268 GO_HYALURONAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 21/45 Gene Ontology BP GO:0030212 3.20314495006126e-06 9.95461981468168e-06 1095 1175.72727272727 1091 2.91195419433606e-07 730 1.92371204345351 1.92196705398875 1 11.3988134515303 1091 1797 976 1725 1399 810 730 798 1454 908 1245 880 M10104 GO_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DEVELOPMENT.html The progression of an endothelial cell over time, from its formation to the mature structure. 27/70 Gene Ontology BP GO:0001885 1.48883059326342e-06 5.82853325845031e-06 660 1060.81818181818 1092 1.35348327347031e-07 393 1.66245498698811 1.4308550553404 1 10.3085649543242 657 1173 642 1115 1092 399 415 2906 1474 1403 393 881 M13699 GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 5/17 Gene Ontology BP GO:0010759 0.000269138414521782 0.000447247551404666 615 1529.18181818182 1092 2.69171016047768e-05 611 1.86336669532632 1.86336669532632 1 7.393500284133 611 1956 4119 1585 2762 924 794 611 1478 1092 889 882 M15818 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. 26/61 Gene Ontology BP GO:1901016 1.55610231372262e-06 6.01584882645259e-06 480 1228.18181818182 1092 1.41463946762255e-07 112 1.49812468510724 1.40481498550341 1 9.26520381751027 480 1092 1333 1314 1102 122 112 4000 2764 966 225 883 M12723 GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 114/303 Gene Ontology BP GO:0050730 6.48477523215859e-06 1.72895203454221e-05 1025 1375.90909090909 1096 5.8952675881125e-07 980 1.65673784980058 1.73414234132289 1 9.34632769248066 1022 2086 1462 1713 1636 1045 1028 1096 2021 980 1046 884 M13223 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 20/44 Gene Ontology BP GO:0030947 0.000296180809438773 0.000488167376011438 515 1788.45454545455 1097 2.69291537344906e-05 131 1.64267397709105 1.7137077968816 1 6.44384533738066 512 3212 1097 2967 3865 340 131 667 3884 2138 860 885 M16060 GO_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTOSIS.html A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. 267/858 Gene Ontology BP GO:0006897 2.91081283425705e-07 2.20016607245287e-06 1100 1411.18181818182 1097 2.64619383580529e-08 283 1.8185357774842 1.93918266520125 1 12.1878716733385 1097 366 283 1031 511 2575 1969 3153 1510 357 2671 886 M16223 GO_ADAPTATION_OF_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTATION_OF_SIGNALING_PATHWAY.html The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. 11/26 Gene Ontology BP GO:0023058 1.69514906730768e-06 6.33192045012837e-06 850 1035.18181818182 1101 1.54104579405387e-07 161 1.25677727090687 1.49889925954691 1 7.7394733975781 848 161 1555 1214 1150 635 355 1101 1658 2245 465 887 M13136 GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. 13/29 Gene Ontology BP GO:2001273 4.19210674608053e-05 8.39687300347364e-05 695 1346.90909090909 1105 3.81107875357652e-06 246 1.25024754049582 1.36201787758472 1 6.03664499021768 693 1273 1907 1105 2363 573 683 825 1975 3173 246 888 M15266 GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 13/33 Gene Ontology BP GO:0060317 1.76579662755679e-06 6.51198867493741e-06 1440 1054.54545454545 1105 1.60527094986206e-07 176 1.93390102496515 2.09433896478505 1 11.8814317226143 1007 1281 1105 1438 1168 843 891 400 1439 1852 176 889 M15449 GO_KERATINIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINIZATION.html The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. 13/66 Gene Ontology BP GO:0031424 1.30268604265898e-06 5.32427050710004e-06 4630 2006.90909090909 1105 1.18426074001739e-07 145 2.62494102673441 -1.81780771214993 -1 16.3989602637545 4630 1105 451 623 1046 4124 2393 2499 145 602 4458 890 M12445 GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH.html Any process that controls the length of actin filaments in a cell. 90/207 Gene Ontology BP GO:0030832 5.36392560848946e-07 3.01875231517777e-06 1090 1153.72727272727 1106 4.87629719663124e-08 248 1.67490562228865 1.79270014824145 1 10.9526958084429 1086 248 1217 372 695 1730 964 1996 1106 1626 1651 891 M15622 GO_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEEDING_BEHAVIOR.html Behavior associated with the intake of food. 30/131 Gene Ontology BP GO:0007631 4.15844206770418e-05 8.33303690994843e-05 555 1266.45454545455 1108 3.78047333881395e-06 380 2.33177540505411 2.47074506733399 1 11.267807037923 551 2144 800 2584 2194 496 380 1108 1547 1633 494 892 M15144 GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 80/237 Gene Ontology BP GO:0070374 2.17861846372979e-07 1.89522081407247e-06 685 1192.18181818182 1109 1.98056243588572e-08 332 1.7812112840445 1.75989163591019 1 12.0744442649388 685 2303 358 1540 332 1109 1074 1502 2492 525 1194 893 M16415 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 23/54 Gene Ontology BP GO:0044246 0.000129022896432811 0.00022882097331457 605 1318.45454545455 1109 1.17300421664016e-05 554 1.87534518076651 2.0662535032445 1 8.08762043887937 605 1691 554 1006 2490 966 953 1631 2060 1438 1109 894 M14023 GO_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 69/211 Gene Ontology BP GO:0042471 8.9977564347777e-09 1.85673702785213e-07 1110 1286.36363636364 1110 8.17977861052501e-10 202 1.8936822795522 2.00688365648256 1 15.1001361613696 1110 253 202 707 463 2788 2254 2465 1497 266 2145 895 M13214 GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS.html The process in which the right cardiac ventricle is generated and organized. 11/27 Gene Ontology BP GO:0003215 6.96955441856362e-07 3.49079192722663e-06 1290 1620.36363636364 1111 6.33596056955e-08 738 1.82291689110465 2.19633855448008 1 11.784330495503 2372 1021 1111 1053 803 3785 3375 1290 738 986 1290 896 M10229 GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. 88/229 Gene Ontology BP GO:0043524 2.06604169700865e-06 7.32261954138255e-06 1260 968.363636363636 1112 1.8782214884103e-07 122 1.77316587888262 2.35897696589142 1 10.7868851546364 1257 393 797 122 1221 1477 1298 478 1112 1824 673 897 M14790 GO_PEPTIDYL_PROLINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_MODIFICATION.html The modification of peptidyl-proline. 23/55 Gene Ontology BP GO:0018208 5.41278891119554e-06 1.49414856805475e-05 885 1120.90909090909 1113 4.92072929876649e-07 599 1.63973108417495 1.84251612084037 1 9.3735161661029 884 1253 1467 1113 1582 1441 1412 778 927 599 874 898 M14995 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. 22/54 Gene Ontology BP GO:0030837 7.1754256724627e-07 3.53667743070534e-06 1485 1310.90909090909 1113 6.52311637524531e-08 289 1.62385592069907 1.42677780289363 1 10.486581521983 1484 289 1425 996 818 1113 906 3567 298 1818 1706 899 M16190 GO_PROTEIN_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HYDROXYLATION.html The addition of a hydroxy group to a protein amino acid. 11/20 Gene Ontology BP GO:0018126 3.95006123981681e-06 1.1666752122436e-05 470 1109.90909090909 1114 3.590971211e-07 54 1.67893367543154 1.89969185630627 1 9.81131201749034 466 2112 1743 1518 2860 226 54 495 1114 1548 73 900 M12937 GO_ENSHEATHMENT_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENSHEATHMENT_OF_NEURONS.html The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. 40/139 Gene Ontology BP GO:0007272 2.91809764393719e-07 2.20016607245287e-06 1430 1114.36363636364 1115 2.65281639181462e-08 425 1.97535558571201 2.09650607553404 1 13.2388820443808 1428 550 1115 491 425 2060 2124 1296 426 1640 703 901 M14268 GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY.html Any process that modulates the activity of the enzyme phospholipase A2. 12/30 Gene Ontology BP GO:0032429 6.63605995284835e-05 0.000125503977030855 4395 2199.36363636364 1115 6.03296375528139e-06 550 2.28318887248728 -2.79781411577734 -1 10.5519798146036 4392 596 991 765 2331 4443 4271 550 670 1115 4069 902 M13182 GO_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT.html Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. 40/139 Gene Ontology BP GO:0008366 2.91809764393719e-07 2.20016607245287e-06 430 1125.09090909091 1116 2.65281639181462e-08 426 1.97535558571201 2.09650607553404 1 13.2388820443808 1429 551 1116 492 426 2061 2125 1404 427 1641 704 903 M15682 GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS.html The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. 63/167 Gene Ontology BP GO:0060560 4.12135982268445e-07 2.61980478260637e-06 1610 1307.45454545455 1116 3.74669144977971e-08 572 1.66415807603551 1.60808473875992 1 11.003770408746 1606 771 735 647 572 1614 1116 2556 1706 612 2447 904 M10293 GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of adipocyte differentiation. 70/139 Gene Ontology BP GO:0045598 3.51460213651402e-06 1.06706110315891e-05 1890 1254.18181818182 1118 3.19509795569696e-07 490 1.94467091830099 2.12604811083996 1 11.4535137906721 1035 1888 541 614 1431 1890 2213 1118 1539 490 1037 905 M15307 GO_DOPAMINERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. 18/46 Gene Ontology BP GO:0071542 2.04920697663451e-07 1.83676988272472e-06 965 1215.81818181818 1118 1.86291560682682e-08 310 1.46486090569813 1.42204842156692 1 9.95358235918184 963 826 1335 847 310 1315 1198 2118 2653 691 1118 906 M11145 GO_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_MORPHOGENESIS.html The process in which the anatomical structures of the lung are generated and organized. 24/70 Gene Ontology BP GO:0060425 6.36687261509423e-08 9.20915562363942e-07 2380 1435.18181818182 1120 5.78806618123058e-09 55 1.98623063744708 1.85008079612785 1 14.2017264125209 2378 288 784 590 55 3231 1895 1982 711 1120 2753 907 M15999 GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 312/759 Gene Ontology BP GO:0045936 1.22495191675962e-07 1.37047030108794e-06 1245 1167.72727272727 1121 1.11359271360409e-08 157 1.53707693108105 1.73106932078577 1 10.6758678435267 1242 1054 1121 1363 157 1073 1147 1021 1932 1717 1018 908 M16735 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL.html The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. 18/73 Gene Ontology BP GO:0003044 2.3174800079193e-06 7.89630384264878e-06 1125 1059.18181818182 1121 2.10680222650577e-07 458 2.09915750003204 2.62456462037782 1 12.6885666054663 1121 458 984 1480 1272 1369 963 609 1401 1352 642 909 M10321 GO_REGULATION_OF_COLLATERAL_SPROUTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COLLATERAL_SPROUTING.html Any process that modulates the frequency, rate or extent of collateral sprouting. 16/35 Gene Ontology BP GO:0048670 2.31448098865424e-05 5.05462616666116e-05 1050 1180.09090909091 1123 2.10409576200446e-06 475 1.67279127798369 1.91318019162456 1 8.51364385080821 1049 1979 1514 1293 2003 911 475 1123 770 1140 724 910 M16798 GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. 37/83 Gene Ontology BP GO:0007266 4.68251855214797e-07 2.8034116821602e-06 4000 1874.90909090909 1125 4.25683595343975e-08 568 1.78406783719907 -1.22282172253226 -1 11.7344666064137 3997 788 886 1390 629 2702 3687 1125 661 568 4191 911 M10433 GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of endocytosis. 73/190 Gene Ontology BP GO:0045807 6.87318462289086e-07 3.45538332145383e-06 1130 1190.18181818182 1128 6.24835160926803e-08 251 1.91257822021762 1.89120221735876 1 12.3739821751014 1128 251 444 950 801 1418 1713 1941 1894 456 2096 912 M15600 GO_LOCALIZATION_WITHIN_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_WITHIN_MEMBRANE.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. 83/194 Gene Ontology BP GO:0051668 1.62411683575452e-06 6.15573425992508e-06 1775 1217.27272727273 1128 1.47647094066866e-07 250 1.67576806638262 1.979638600221 1 10.3440280479316 1772 250 824 649 1128 2417 1819 1091 552 1290 1598 913 M10366 GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. 5/17 Gene Ontology BP GO:0031953 1.0878718190081e-05 2.65004661891638e-05 1560 1445.81818181818 1130 1.08787714463772e-06 214 1.40304945698407 1.61335788145614 1 7.60690237085976 1560 1130 3574 1094 2086 1976 850 214 734 1083 1603 914 M13374 GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. 15/57 Gene Ontology BP GO:2000179 6.39814245063656e-06 1.71182047075419e-05 2065 1200.45454545455 1130 5.81651005280741e-07 184 2.04422534724412 2.27870877761584 1 11.5427745136512 2064 1009 1332 665 1630 2352 1444 184 378 1017 1130 915 M14160 GO_AMELOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMELOGENESIS.html The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. 8/23 Gene Ontology BP GO:0097186 2.13868953497233e-05 4.7167982849085e-05 765 1363.63636363636 1130 2.13871011821931e-06 329 1.48450784491806 1.60775428857655 1 7.6082088205292 762 1359 4194 1602 2010 414 329 1516 1130 1056 628 916 M15524 GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. 39/105 Gene Ontology BP GO:0007422 8.80249202923827e-06 2.21998753350099e-05 215 1164.72727272727 1132 8.00229749943147e-07 209 1.59132143638932 1.64880354951608 1 8.77262567434726 213 1788 1132 2014 1721 224 449 546 2098 2418 209 917 M10348 GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 4/15 Gene Ontology BP GO:0035589 0.000146094807420516 0.000255487077534258 1035 1454.45454545455 1134 1.46104412971038e-05 186 2.62445051366694 2.62445051366694 1 11.1693794420873 1032 1134 3570 1516 2552 1110 1473 965 186 1694 767 918 M12526 GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. 9/23 Gene Ontology BP GO:0021681 7.62253144326464e-07 3.66370740073268e-06 2160 1585.45454545455 1134 7.62253405790025e-08 130 1.76749143876282 -1.45160946570171 -1 11.3820668839728 2159 166 3924 523 882 2007 3169 2576 130 770 1134 919 M16865 GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. 82/178 Gene Ontology BP GO:0071901 1.64214393748369e-06 6.20885529457392e-06 1055 1358.72727272727 1134 1.49285923929903e-07 437 1.7573138960179 2.04815212016224 1 10.8396183841648 2249 1608 1026 1052 1134 2526 1476 437 1053 1049 1336 920 M16165 GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. 20/59 Gene Ontology BP GO:0046622 1.65349750175355e-06 6.22998341176575e-06 1075 1117.54545454545 1139 1.50318067682425e-07 137 2.66830972923439 3.21483535060125 1 16.4542405296827 1072 1412 936 892 1139 1579 1433 137 843 1574 1276 921 M10496 GO_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. 361/931 Gene Ontology BP GO:0043408 1.14657153208414e-07 1.31726257509087e-06 990 992.818181818182 1140 1.04233781076353e-08 150 1.64864353123734 1.78076792254077 1 11.4843475281743 989 1140 256 757 150 1329 1456 1550 1850 285 1159 922 M10056 GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 283/699 Gene Ontology BP GO:0033674 4.31639842549019e-07 2.70268065982377e-06 1110 1251.90909090909 1141 3.92399933851589e-08 367 1.56790966968898 1.64824188267387 1 10.3422327266493 1106 1141 419 694 588 2220 2298 2008 1712 367 1218 923 M13900 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that activates, maintains or increases the rate of developmental growth. 97/260 Gene Ontology BP GO:0048639 3.97890748836616e-07 2.61302227277003e-06 1265 1156.45454545455 1141 3.61718927999026e-08 503 1.92354845939768 2.15886815002302 1 12.7214809325261 1261 1738 503 558 546 1879 2220 829 1375 671 1141 924 M11043 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of glia cell differentiation. 16/45 Gene Ontology BP GO:0045687 2.44049248257835e-06 8.19855180955454e-06 1705 1254.45454545455 1142 2.218631990779e-07 122 2.81961802152561 3.82427236841076 1 16.9889734177738 1702 926 916 338 1292 2309 2511 1760 122 1142 781 925 M15850 GO_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEATH.html The process of cell death in a neuron. 40/89 Gene Ontology BP GO:0070997 1.55837810585635e-06 6.01584882645259e-06 1000 1217.27272727273 1142 1.4167083724912e-07 76 1.73560631367141 2.05224597089634 1 10.7339174117896 998 1787 1312 1284 1146 1142 1101 76 905 2877 762 926 M10624 GO_RESPONSE_TO_STEROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 274/831 Gene Ontology BP GO:0048545 1.60003960798211e-20 2.85730149994651e-18 2165 1590 1144 1.45458146180191e-21 25 1.97460724609278 2.17529157585152 1 41.038220101245 2163 506 25 49 609 3784 3312 3050 1144 33 2815 927 M11126 GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. 3/20 Gene Ontology BP GO:2000311 3.1070427346039e-05 6.45458586879906e-05 1760 1343.18181818182 1144 3.10708617717426e-06 205 1.66347750193715 2.14462411182638 1 8.25700617999836 1759 621 3696 1144 2609 979 205 322 245 1417 1778 928 M15082 GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. 261/608 Gene Ontology BP GO:0042326 1.10800832097597e-07 1.29465148368895e-06 1055 1087 1145 1.00728034252702e-08 135 1.53953131813013 1.76012245709717 1 10.7379922709393 1054 1145 1203 1283 135 831 1087 1198 1780 1480 761 929 M13280 GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 312/759 Gene Ontology BP GO:0010563 1.22495191675962e-07 1.37047030108794e-06 1245 1188.54545454545 1146 1.11359271360409e-08 156 1.53707693108105 1.73106932078577 1 10.6758678435267 1241 1053 1120 1362 156 1072 1146 1260 1931 1716 1017 930 M16232 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html The directed movement of a protein to a specific location in the plasma membrane. 55/130 Gene Ontology BP GO:0090002 6.08550335752942e-07 3.23212152206309e-06 3340 2116.63636363636 1147 5.53227730987656e-08 507 1.80496222105132 -1.9056656118306 -1 11.7397547954612 3340 893 1147 826 741 4088 3206 3165 507 1104 4266 931 M14964 GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC.html Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. 4/18 Gene Ontology BP GO:0040034 2.82985570653601e-05 5.96685742300032e-05 2125 1760.18181818182 1148 2.82989174355682e-06 50 2.37194582521008 2.91184410497235 1 11.8695120208334 2124 730 4325 110 2105 3170 4019 1148 50 899 682 932 M10982 GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 13/54 Gene Ontology BP GO:0090184 2.57560325334478e-06 8.50683969416687e-06 1960 1473.63636363636 1149 2.34146024425682e-07 376 1.87937788542917 1.81354322929166 1 11.2880769103294 1956 929 667 376 1315 1623 1149 4443 1014 600 2138 933 M14911 GO_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of neuron death. 172/401 Gene Ontology BP GO:1901214 1.17871550724954e-06 4.94379051504932e-06 1150 1319 1149 1.0715601261654e-07 706 1.61051818043763 1.94602310562274 1 10.1229243422651 1149 1782 1261 781 1008 1118 1246 795 1934 2729 706 934 M13423 GO_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. 796/2245 Gene Ontology BP GO:0045595 5.66293069091364e-16 4.248129705327e-14 745 1195.54545454545 1150 5.66293069091364e-17 7 1.73567203226187 1.84087717839788 1 27.4938580059924 742 735 4073 407 341 1481 1390 1150 1638 7 1187 935 M11353 GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cell junction assembly. 66/135 Gene Ontology BP GO:1901888 4.04693909661094e-05 8.12915731657613e-05 265 1045.18181818182 1153 3.67910322062914e-06 265 1.76625431295639 1.6747118334081 1 8.55755551624281 265 1740 437 1153 2317 702 364 1405 1268 492 1354 936 M11091 GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme adenylate cyclase. 13/45 Gene Ontology BP GO:0007190 3.27323644543961e-05 6.74251855198585e-05 510 1273.18181818182 1155 2.97571376982115e-06 351 1.36657597571261 1.50449678387692 1 6.75259157715577 508 467 1155 1475 2129 425 642 1817 3198 1838 351 937 M10421 GO_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a gland are generated and organized. 69/166 Gene Ontology BP GO:0022612 1.52356276997764e-06 5.92553621667409e-06 2995 1784.90909090909 1157 1.3850580228085e-07 232 1.95855250251564 -1.66692154337901 -1 12.1279776273914 2994 1157 456 232 1096 3881 2706 2551 382 387 3792 938 M10422 GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. 19/70 Gene Ontology BP GO:0002820 2.23091777424008e-05 4.89284422569517e-05 1160 1486.81818181818 1157 2.02812763387434e-06 278 2.20694802861874 -2.44532057619951 -1 11.2691616120653 1157 2633 1076 2394 3288 913 1391 278 1058 747 1420 939 M15854 GO_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_MEDIATED_ENDOCYTOSIS.html An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. 103/399 Gene Ontology BP GO:0006898 1.47043320346088e-08 2.86858040490289e-07 825 1318.81818181818 1157 1.33675746662631e-09 192 1.82087730301432 1.80231994477958 1 14.1120912581711 823 757 211 1157 192 2170 2043 3616 1560 217 1761 940 M16041 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 57/140 Gene Ontology BP GO:0090100 9.27575340339619e-07 4.19986475613013e-06 1505 1253.27272727273 1158 8.43250664935407e-08 586 1.91430963681045 2.11128442810935 1 12.1930192114079 1505 1158 586 594 914 2516 1619 1778 1071 667 1378 941 M13295 GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 25/69 Gene Ontology BP GO:0060393 3.14809055547123e-06 9.83619411107194e-06 965 1252.09090909091 1160 2.8619046002193e-07 238 1.67097805590035 1.88613374160559 1 9.91154514418887 961 2549 1160 2422 1391 851 443 238 1272 2128 358 942 M16163 GO_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 223/596 Gene Ontology BP GO:0048568 5.03877058093137e-11 1.63601481169681e-09 1160 1190.90909090909 1160 4.58070052822433e-12 130 1.74314280773077 1.74837237235535 1 18.1431522813998 1160 372 132 442 130 2258 1740 2612 1765 240 2249 943 M11530 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 16/35 Gene Ontology BP GO:0043243 1.59488563869287e-06 6.08798146965442e-06 3765 1996.54545454545 1161 1.44989708627566e-07 413 1.96861985601395 -2.24329031464389 -1 12.1629262676728 3764 1343 1114 1043 1119 3622 3128 1161 413 1145 4110 944 M16678 GO_LENS_FIBER_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. 13/29 Gene Ontology BP GO:0070307 9.68538584527774e-07 4.29916314336755e-06 2220 1408.27272727273 1161 8.80490009929204e-08 121 2.11189064086926 2.16445703324316 1 13.4261037832058 2218 1427 1001 121 937 2326 1161 2796 174 603 2727 945 M11876 GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 14/42 Gene Ontology BP GO:0060079 4.54339799455489e-06 1.3005546787126e-05 1275 1132.72727272727 1162 4.13037034320074e-07 504 1.49812983412863 1.51880933121506 1 8.67100627661345 640 1271 1639 1494 1524 1274 504 1122 898 932 1162 946 M13852 GO_DICARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSPORT.html The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/107 Gene Ontology BP GO:0006835 1.75221983435727e-06 6.46705619310081e-06 4220 2102.09090909091 1166 1.5929283908528e-07 243 2.42240377142352 2.45650397146628 1 14.8913067499895 4220 283 557 946 1166 3488 4129 3220 243 517 4354 947 M14129 GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. 158/476 Gene Ontology BP GO:0072507 7.7901937911484e-07 3.71735557783165e-06 730 1389.27272727273 1166 7.0819968633229e-08 301 1.67985475544218 1.85242151443021 1 10.8051517986634 726 1732 301 1953 869 1149 1166 2722 2901 549 1214 948 M13149 GO_HEPATOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a hepatocyte, the main structural component of the liver. 9/17 Gene Ontology BP GO:0097284 1.74350280334042e-06 6.4451301878261e-06 1200 1235.63636363636 1167 1.74350417125285e-07 178 1.76832149164598 -2.02489433836318 -1 10.8735386861201 1196 478 4022 1167 1196 755 1449 1038 178 1200 913 949 M12547 GO_ETHANOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. 6/17 Gene Ontology BP GO:0006067 5.3543266108346e-05 0.000104060855814588 795 1536.81818181818 1168 5.35445562487012e-06 581 1.67438337723136 -1.67438337723136 -1 7.89972333752747 791 1037 3928 1989 2288 642 581 1168 2061 1301 1119 950 M12940 GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 530/1413 Gene Ontology BP GO:0010562 1.52857172073478e-07 1.53951377426715e-06 935 1340.27272727273 1168 1.5285718258787e-08 108 1.56980745405047 1.68780456639613 1 10.8092630433512 933 867 3985 582 246 1851 1778 1171 2054 108 1168 951 M16607 GO_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION.html The addition of tubulin heterodimers to one or both ends of a microtubule. 13/34 Gene Ontology BP GO:0046785 0.000326164665280091 0.0005330455969361 760 1322.54545454545 1170 2.96557301277347e-05 439 1.62522976671654 1.73879905568242 1 6.30187848907173 756 2029 2024 1170 2692 882 600 2095 439 1259 602 952 M11056 GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION.html The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. 4/18 Gene Ontology BP GO:0048505 2.82985570653601e-05 5.96685742300032e-05 2125 1702.36363636364 1172 2.82989174355682e-06 49 2.37194582521008 2.91184410497235 1 11.8695120208334 2123 729 3678 109 2104 3169 4018 1172 49 894 681 953 M12232 GO_FATTY_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. 28/61 Gene Ontology BP GO:0035337 1.8695184940381e-06 6.77080683917231e-06 925 1540 1174 1.69956371156503e-07 169 1.3042224070511 -0.970861691100455 -1 7.98668231353207 923 1174 2608 2310 1192 169 331 3971 713 3264 285 954 M12424 GO_NEGATIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 264/670 Gene Ontology BP GO:0051051 1.34490291498541e-07 1.43549062856948e-06 1570 1340 1174 1.22263908836541e-08 183 1.5329532651997 1.7337280302882 1 10.6106699811732 1568 507 409 953 183 2187 1833 3351 2073 502 1174 955 M14694 GO_COCHLEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_DEVELOPMENT.html The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. 21/75 Gene Ontology BP GO:0090102 4.64924319740696e-07 2.80251696730727e-06 1175 1281.18181818182 1175 4.2265856181166e-08 494 1.88736205457328 2.08557367110513 1 12.414180491641 1175 574 525 494 623 2479 1861 2757 1621 510 1474 956 M10621 GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 29/68 Gene Ontology BP GO:0010718 0.00338990589381747 0.00474648162394286 445 1232.72727272727 1176 0.000308649143767557 420 2.23845383543315 2.46703466240649 1 6.16158952707152 442 2096 850 1187 3149 1231 1205 1176 420 684 1120 957 M11200 GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. 13/26 Gene Ontology BP GO:2000251 1.7893350664828e-06 6.55195797608804e-06 445 1127.72727272727 1176 1.62666956528338e-07 283 1.79034611011397 1.79034611011397 1 10.9938279082658 445 1500 1313 2011 1176 380 577 439 1811 2470 283 958 M16698 GO_ASTROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DEVELOPMENT.html The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 11/39 Gene Ontology BP GO:0014002 2.1688651823042e-06 7.59752263029601e-06 1005 1377.36363636364 1177 1.97169756407104e-07 94 2.04000138021821 2.29443911937495 1 12.3714743707902 1005 2847 1607 1544 3115 1137 1177 94 437 1551 637 959 M11402 GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. 6/17 Gene Ontology BP GO:0045835 4.52359929460998e-06 1.29648589659717e-05 1180 1487.36363636364 1178 4.52360850296413e-07 146 1.76505107446414 1.48962880236821 1 10.2187619187051 1178 1299 3738 1013 1560 547 146 3854 489 2176 361 960 M16354 GO_REGULATION_OF_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of organ morphogenesis. 130/309 Gene Ontology BP GO:2000027 1.81181618448094e-06 6.61861726557435e-06 1355 1217.36363636364 1178 1.64710697873543e-07 221 1.77453893004839 1.94990593021654 1 10.8875206750367 1353 636 782 221 1178 2381 1562 2094 1147 789 1248 961 M11722 GO_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. 196/485 Gene Ontology BP GO:0016055 7.70025569310209e-06 1.99066186988157e-05 505 1293.72727272727 1179 7.00025695002185e-07 177 1.93547314544601 2.10945279709292 1 10.7784339851895 504 3082 1278 2037 2314 435 446 177 1179 2420 359 962 M11529 GO_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 12/54 Gene Ontology BP GO:0006584 5.73541738312644e-05 0.000110587802781794 1070 1642.36363636364 1180 5.21415173760757e-06 390 2.41033693048157 2.92711661963475 1 11.2965080050331 1069 2863 1180 3058 3123 806 478 390 1855 2342 902 963 M12838 GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 73/173 Gene Ontology BP GO:0010594 2.34179575933393e-06 7.94309415357294e-06 670 1163.63636363636 1181 2.12890750188024e-07 517 1.60740719543413 1.56459188987508 1 9.7112466992544 666 1240 517 810 1277 1181 997 2123 1825 552 1612 964 M13786 GO_REGULATION_OF_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. 19/38 Gene Ontology BP GO:0030823 2.43659284779595e-05 5.27714043120866e-05 1370 1222.63636363636 1181 2.21510894046228e-06 572 1.53680938145981 1.6280119491683 1 7.78750464837307 1367 1186 815 655 2015 1431 1173 888 2166 572 1181 965 M15740 GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. 12/54 Gene Ontology BP GO:0009712 6.87053666206286e-05 0.000129516450353057 1070 1647 1181 6.24613748756944e-06 413 2.41033693048157 2.92711661963475 1 11.1005820203916 1070 2864 1181 3059 3124 807 479 413 1856 2361 903 966 M13500 GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 10/29 Gene Ontology BP GO:0030206 2.17799735869971e-05 4.79262641537571e-05 170 1136.90909090909 1182 1.98001720104206e-06 73 1.85606970191585 1.85606970191585 1 9.49726129698181 169 1939 1172 1716 1989 247 73 1182 2096 1372 551 967 M13512 GO_POSITIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXON_EXTENSION.html Any process that activates or increases the frequency, rate or extent of axon extension. 26/54 Gene Ontology BP GO:0045773 2.35954800517031e-06 7.97893949495477e-06 560 1264.81818181818 1182 2.14504594167348e-07 289 2.0155570131464 2.11490932140916 1 12.1724396743415 556 3148 1118 2406 1281 662 1182 289 1528 1276 467 968 M10060 GO_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSPORT.html The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/175 Gene Ontology BP GO:0006813 3.40349899924245e-07 2.42741103740133e-06 1280 1187.54545454545 1183 3.09409047798106e-08 236 1.71222021576013 1.73159695422119 1 11.3887571687223 1276 405 594 1158 473 1840 1588 2745 1565 236 1183 969 M15489 GO_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 36/79 Gene Ontology BP GO:0046677 6.03844481270826e-07 3.23212152206309e-06 780 1454.27272727273 1184 5.48949679100874e-08 47 2.41675099816306 2.41675099816306 1 15.7189246501021 780 2835 1173 1673 2947 1804 1184 47 1038 2156 360 970 M11005 GO_APICAL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_ASSEMBLY.html The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. 35/65 Gene Ontology BP GO:0043297 4.68115869222828e-06 1.33177817451078e-05 3800 1778.72727272727 1185 4.25560786620422e-07 498 1.9967760989055 -2.12230661430315 -1 11.5327435641148 3796 1163 653 626 1535 3302 3909 1185 498 790 2109 971 M14342 GO_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASOCONSTRICTION.html Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. 35/92 Gene Ontology BP GO:0019229 4.71815519812383e-06 1.33960977678131e-05 735 1353.81818181818 1186 4.28924119707758e-07 506 1.72875178001108 1.70210853273299 1 9.97950530456389 735 1087 942 1369 1538 1186 793 2830 2050 506 1856 972 M14969 GO_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of MAP kinase activity. 194/484 Gene Ontology BP GO:0043405 8.22994089157683e-07 3.83930494928787e-06 1190 1175.27272727273 1186 7.48176724572944e-08 420 1.70862453124271 1.87137566933915 1 10.9618302271636 1186 1370 420 824 874 1793 1687 1882 1246 462 1184 973 M12569 GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. 19/63 Gene Ontology BP GO:0061005 2.02957279897222e-06 7.22646204419328e-06 1300 978 1188 1.84506788302065e-07 153 2.46846376142851 2.73046066736225 1 15.0334510285776 1300 294 351 153 1214 1751 1188 1730 177 412 2188 974 M16129 GO_NEGATIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXONOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. 45/105 Gene Ontology BP GO:0050771 3.44190297994504e-06 1.0555320697414e-05 650 1038.45454545455 1188 3.12900760438064e-07 267 1.74035848011202 1.80751722251598 1 10.2599027825356 648 267 598 698 1419 1626 1313 1208 1775 683 1188 975 M10979 GO_NOTCH_RECEPTOR_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_RECEPTOR_PROCESSING.html The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. 9/20 Gene Ontology BP GO:0007220 5.67677432417467e-05 0.00010959360992575 3065 1856 1191 5.67691934533889e-06 74 2.62338261184033 3.0671270605586 1 12.3071761577195 3061 845 3664 428 2311 3506 3866 451 74 1191 1019 976 M12652 GO_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT.html The directed movement of calcium ions into a cell or organelle. 38/111 Gene Ontology BP GO:0070509 0.000152100064978789 0.000264692879196596 420 1439.72727272727 1191 1.38282346951469e-05 345 1.73420821200561 1.75900302169018 1 7.3490207387964 419 3111 1196 1965 2535 434 345 1191 2772 1175 694 977 M14830 GO_CELLULAR_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a cell. 8/16 Gene Ontology BP GO:0009992 1.162177409314e-05 2.81041130804422e-05 1375 1739.54545454545 1194 1.16218348731222e-06 133 2.53328356226658 2.19544764136776 1 13.6581113116027 1372 1027 4300 1194 2247 1091 190 3878 2643 1060 133 978 M16246 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. 16/42 Gene Ontology BP GO:1901381 1.65356971572454e-06 6.22998341176575e-06 1625 1455 1194 1.50324632598747e-07 505 1.30877450512467 1.17228180321547 1 8.07061038833737 871 1194 1625 1432 1140 719 505 3653 2320 1624 922 979 M14077 GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. 13/40 Gene Ontology BP GO:0046460 1.95210905449862e-05 4.35542640078669e-05 1770 1388.63636363636 1196 1.77466034201156e-06 792 2.08226756377668 -1.99953365401592 -1 10.7571592798798 1770 1196 1088 1812 1961 1069 1703 1064 792 860 1960 980 M14022 GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that increases the extent to which blood vessels can be pervaded by fluid. 6/13 Gene Ontology BP GO:0043117 8.13388515691975e-05 0.000150520640827335 1200 1512 1197 8.13418289265245e-06 457 1.49094871908632 1.83492000843058 1 6.75114257699722 1197 2612 4172 1583 2404 823 901 489 457 1309 685 981 M16472 GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 13/40 Gene Ontology BP GO:0046463 1.95210905449862e-05 4.35542640078669e-05 1965 1387.54545454545 1197 1.77466034201156e-06 793 2.08226756377668 -1.99953365401592 -1 10.7571592798798 1771 1197 1089 1813 1962 1070 1704 1040 793 863 1961 982 M12235 GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. 13/19 Gene Ontology BP GO:0031065 7.25991746692452e-06 1.89796153147131e-05 1015 1884 1199 6.59994674953681e-07 175 2.79089953052212 2.79089953052212 1 15.6106794493734 1013 4165 1950 3500 4155 1199 829 175 379 2474 885 983 M15093 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. 11/16 Gene Ontology BP GO:0010667 3.67869456367937e-06 1.10694613474811e-05 1810 1285.54545454545 1199 3.34427337723966e-07 457 1.8861356373334 2.02059951133518 1 11.0731496670671 1806 1115 1299 1177 1448 1964 1199 1049 1084 1543 457 984 M10711 GO_NITROGEN_CYCLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_CYCLE_METABOLIC_PROCESS.html A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. 7/30 Gene Ontology BP GO:0071941 1.00596134512008e-06 4.42718343639102e-06 1000 1379.36363636364 1200 1.00596180050157e-07 313 1.88791112860017 -2.29236139968284 -1 11.9736789775371 996 719 3623 1200 984 1354 1934 405 313 2373 1272 985 M14332 GO_MECHANORECEPTOR_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANORECEPTOR_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. 25/96 Gene Ontology BP GO:0042490 3.55502248850698e-07 2.49281718252034e-06 1165 1576.45454545455 1202 3.2318391481546e-08 486 1.94560044509232 2.06066005986331 1 12.9144620078464 1161 1551 882 1281 486 3158 3961 2162 823 674 1202 986 M12866 GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. 959/2715 Gene Ontology BP GO:0071310 3.14579703616445e-07 2.30377533736775e-06 1125 1425.27272727273 1203 3.14579748148628e-08 223 1.71335551638746 1.86844965153932 1 11.4423885875521 1125 493 3972 580 480 1894 1791 1952 1965 223 1203 987 M10370 GO_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_BINDING.html Any process that modulates the frequency, rate or extent of protein binding. 119/277 Gene Ontology BP GO:0043393 1.97659037705984e-06 7.09768686828218e-06 570 1440 1204 1.79690195720913e-07 569 1.58142075004715 1.78148009398087 1 9.64580540209319 569 2001 1738 1459 1204 1026 1139 833 2068 3098 705 988 M10802 GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM.html The growth process in which a branch increases in length from its base to its tip. 10/23 Gene Ontology BP GO:0060602 4.40998326850542e-06 1.26937383633239e-05 1065 1184.63636363636 1205 4.00908373500782e-07 139 1.79095648554838 -2.09241912330046 -1 10.3882138695483 1065 938 1598 563 1703 1218 1624 139 922 2056 1205 989 M14938 GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase B. 16/37 Gene Ontology BP GO:0032148 4.32847642818e-07 2.70268065982377e-06 4130 2078.54545454545 1206 3.93497934527576e-08 149 1.79713950314195 1.80183820924171 1 11.8542768939869 4126 149 1206 772 589 3662 4403 3114 191 1151 3501 990 M15391 GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/39 Gene Ontology BP GO:0032891 4.86809267111594e-05 9.59768758895596e-05 680 1312.54545454545 1209 4.42563672192533e-06 679 1.85456200958758 2.08739249618046 1 8.82696290959583 679 1201 1209 1584 2236 1178 995 1317 889 1663 1487 991 M15515 GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 21/58 Gene Ontology BP GO:0071470 6.86757631192656e-07 3.45538332145383e-06 2065 1348.72727272727 1211 6.24325314157064e-08 295 1.63008919572198 1.89495591973638 1 10.5463368574398 2065 295 1211 1076 800 2664 1941 959 1705 511 1609 992 M14446 GO_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_REGENERATION.html The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. 19/47 Gene Ontology BP GO:0031102 7.39765836056697e-05 0.000138486635605961 770 1370.18181818182 1213 6.72537011260473e-06 397 1.74469237383809 1.61575296607987 1 7.97490921098687 767 578 1634 1213 2358 1027 757 3053 397 2024 1264 993 M14282 GO_METANEPHRIC_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. 9/23 Gene Ontology BP GO:0072075 1.89237131518121e-05 4.24663123073289e-05 1220 1249.81818181818 1216 1.89238743018572e-06 69 2.35955025883127 2.5827103846312 1 12.2203319223716 1216 330 4216 416 1977 1581 1665 445 69 522 1311 994 M14682 GO_KIDNEY_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. 9/27 Gene Ontology BP GO:0072074 1.89237131518121e-05 4.24663123073289e-05 1220 1255 1217 1.89238743018572e-06 70 2.35955025883127 2.5827103846312 1 12.2203319223716 1217 331 4273 417 1978 1582 1666 436 70 523 1312 995 M12067 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 6/15 Gene Ontology BP GO:0040037 3.90343694392925e-07 2.57804519639595e-06 1220 1285.09090909091 1219 3.90343762958631e-08 38 1.54848989969449 -1.72900968812067 -1 10.2517484428587 1219 339 3845 509 1902 1543 2588 38 126 1299 728 996 M12614 GO_SULFUR_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 23/44 Gene Ontology BP GO:0044273 1.35749194115426e-05 3.19454388382121e-05 610 1115.45454545455 1219 1.23409119774474e-06 230 2.01538919121103 2.07419413221844 1 10.7330651474749 608 1554 1403 2028 1852 486 230 1219 522 1898 470 997 M15797 GO_ADENOHYPOPHYSIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOHYPOPHYSIS_DEVELOPMENT.html The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. 3/17 Gene Ontology BP GO:0021984 1.5142275121889e-06 5.90803221772527e-06 1220 1458.45454545455 1220 1.51422854398812e-07 41 2.79141345529703 -2.79141345529703 -1 17.2895657666458 1359 2083 4459 344 2540 1220 1219 84 41 2596 98 998 M16251 GO_REGULATION_OF_CELLULAR_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. 38/95 Gene Ontology BP GO:0030641 1.20451798997865e-05 2.9022195264509e-05 1090 1297 1220 1.09502234987609e-06 696 1.66736997072522 -1.51241443253193 -1 8.96199288046433 1089 1619 1399 1605 1801 696 1808 712 1142 1176 1220 999 M16711 GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION.html Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. 8/23 Gene Ontology BP GO:0048070 5.25168006133953e-05 0.000102494958069775 1220 1800.27272727273 1220 5.25180417611328e-06 391 1.62175936420302 -1.65505307257002 -1 7.66409439729426 1220 1868 4609 2206 3364 841 832 391 1098 2551 823 1000 M12474 GO_REGULATION_OF_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_PLASTICITY.html A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 73/229 Gene Ontology BP GO:0048167 1.53957049180576e-07 1.54723502022817e-06 1135 1265.45454545455 1221 1.39960963595059e-08 220 1.69133657517555 1.81460848513594 1 11.6417261201038 1134 2456 1221 1340 220 1135 988 1352 1501 1069 1504 1001 M13662 GO_NEGATIVE_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANOIKIS.html Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. 21/35 Gene Ontology BP GO:2000811 1.09371670122287e-06 4.67828054520338e-06 2035 1734.09090909091 1222 9.94288404507176e-08 299 1.70998084750646 1.74323411895059 1 10.796660877271 2035 299 1187 735 979 2722 2670 4231 652 1222 2343 1002 M14845 GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 37/107 Gene Ontology BP GO:0042108 1.33521570319232e-07 1.42862049115788e-06 1975 1400.72727272727 1223 1.21383253111703e-08 180 1.21858995456407 -1.46605722762593 -1 8.43774314099453 1973 422 1956 1061 180 1223 3394 446 1753 1865 1135 1003 M16469 GO_TRIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 19/44 Gene Ontology BP GO:0072512 0.000124957025048625 0.000222204315320094 595 1406.36363636364 1223 1.13603748184634e-05 534 1.67054811086628 -1.53172782535829 -1 7.2296302313863 592 1414 2259 1909 2484 534 814 1223 1191 2029 1021 1004 M13824 GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. 13/40 Gene Ontology BP GO:0046885 1.8586787322182e-05 4.19127991922735e-05 1580 1249.81818181818 1224 1.68972221411362e-06 252 2.50666519045036 2.67123388474575 1 12.9991735613873 1579 2229 1062 766 1944 1151 922 1224 252 1252 1367 1005 M13979 GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 84/208 Gene Ontology BP GO:0090090 1.53035248552495e-05 3.54562205104409e-05 955 1387.18181818182 1225 1.39123920998772e-06 241 2.05797924903579 2.22554144083416 1 10.849483203155 952 2131 1346 1225 2828 2126 1208 241 772 1585 845 1006 M10180 GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. 62/154 Gene Ontology BP GO:0002244 5.57575806994875e-07 3.09534389000729e-06 1045 1400.90909090909 1226 5.06887225735379e-08 451 1.95190630165157 2.31551785038608 1 12.7389235204328 1045 3424 858 2716 706 1238 1502 548 1696 1226 451 1007 M10519 GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 13/54 Gene Ontology BP GO:0030800 1.06055925029737e-05 2.60263033780693e-05 485 1204.45454545455 1226 9.64149420904698e-07 171 1.78394837346099 1.78394837346099 1 9.68858994302802 485 1014 1226 1875 1772 184 171 1407 2442 2466 207 1008 M13657 GO_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE.html The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. 240/732 Gene Ontology BP GO:0006954 2.97859508294134e-16 2.51447581274484e-14 1180 1251.63636363636 1228 2.70781371176485e-17 51 1.81517029610588 1.96244944583227 1 29.2428752694212 1176 1228 51 1111 676 2324 1803 1606 1852 78 1863 1009 M10256 GO_CARBOHYDRATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORT.html The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. 48/126 Gene Ontology BP GO:0008643 7.34300868046059e-07 3.59637017968128e-06 1230 1919.72727272727 1229 6.67546466487334e-08 407 1.79567153521485 1.85756477858554 1 11.5806749466548 2854 407 458 679 826 4253 2701 3321 1227 1229 3162 1010 M12452 GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. 47/109 Gene Ontology BP GO:0035050 2.98341298832334e-06 9.46173941583695e-06 1330 1298.18181818182 1229 2.71219730375261e-07 617 1.76950195835366 1.97706397497635 1 10.5312814375617 1327 974 1079 617 1373 1996 1186 1824 1732 943 1229 1011 M14231 GO_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/57 Gene Ontology BP GO:0032371 3.21828974502413e-05 6.63816938522746e-05 930 1179.09090909091 1230 2.92576075002609e-06 262 2.47061215555493 2.47061215555493 1 12.2277352667717 930 1334 1230 561 2123 1478 1880 448 1039 1685 262 1012 M12714 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. 81/177 Gene Ontology BP GO:0017015 1.2020548758324e-06 4.9965450210294e-06 1270 1334.54545454545 1231 1.09277775692906e-07 448 1.87717702148347 1.80744786499791 1 11.7887599474944 1266 1967 747 448 1017 2094 2039 2050 1104 717 1231 1013 M15298 GO_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/57 Gene Ontology BP GO:0032374 3.21828974502413e-05 6.63816938522746e-05 935 1183 1231 2.92576075002609e-06 263 2.47061215555493 2.47061215555493 1 12.2277352667717 931 1335 1231 562 2124 1479 1881 480 1040 1687 263 1014 M13980 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 81/177 Gene Ontology BP GO:1903844 1.2020548758324e-06 4.9965450210294e-06 1270 1321.27272727273 1232 1.09277775692906e-07 449 1.87717702148347 1.80744786499791 1 11.7887599474944 1267 1968 748 449 1018 2095 2040 1894 1105 718 1232 1015 M13554 GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. 61/118 Gene Ontology BP GO:0048013 9.23913337484955e-06 2.31252270940304e-05 540 1228.09090909091 1233 8.39924743254397e-07 539 1.90788132522815 2.0543253606694 1 10.477671044338 798 1384 1695 1233 1736 1644 1053 539 540 1773 1114 1016 M13957 GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of glucose across a membrane. 6/22 Gene Ontology BP GO:1904659 0.00027885580107161 0.000461907771807166 575 1431.90909090909 1233 2.78890799503801e-05 335 2.39684298748768 2.39684298748768 1 9.47046619855401 574 1448 4165 1352 2674 734 335 1233 879 1308 1049 1017 M12634 GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). 18/46 Gene Ontology BP GO:0007205 4.21256820846505e-06 1.22703602207674e-05 720 1339.09090909091 1234 3.82961479520727e-07 718 1.92882925920787 2.02473857665525 1 11.2215894123576 718 2551 1234 2077 1502 812 837 1673 1626 952 748 1018 M15018 GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 33/83 Gene Ontology BP GO:0050810 1.42318124633421e-06 5.6622369552097e-06 2305 1609.09090909091 1235 1.29380196999254e-07 672 2.15218177273044 -1.8329796378424 -1 13.3773179718898 2303 1395 1059 771 1075 1235 2740 3845 672 1467 1138 1019 M12058 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation. 68/174 Gene Ontology BP GO:0030856 2.47823138215221e-07 2.00203502611962e-06 2525 1377.45454545455 1236 2.25293787392481e-08 254 1.95838384886215 -1.82666397557407 -1 13.2202167856709 2524 254 527 1135 379 1724 3182 1622 1236 626 1943 1020 M12792 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. 25/56 Gene Ontology BP GO:0010882 1.46464022032752e-05 3.41381754165696e-05 705 1407 1236 1.33149997381414e-06 377 1.83854461562804 1.68813844489352 1 9.72847547739133 701 1794 1236 1224 1867 458 377 2682 1878 2602 658 1021 M11198 GO_HEXOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. 6/22 Gene Ontology BP GO:0035428 0.00027885580107161 0.000461907771807166 575 1388.72727272727 1237 2.78890799503801e-05 334 2.39684298748768 2.39684298748768 1 9.47046619855401 573 1447 3705 1351 2673 733 334 1237 878 1297 1048 1022 M11589 GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 455/1065 Gene Ontology BP GO:0044087 2.27599225019713e-07 1.93897835186519e-06 1260 1077.27272727273 1238 2.069084077871e-08 205 1.63555483856396 1.81986769718407 1 11.0678639514693 1258 205 656 239 343 1974 1798 1238 1558 1228 1353 1023 M13475 GO_RESPONSE_TO_ESTROGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTROGEN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 127/351 Gene Ontology BP GO:0043627 5.73262576812479e-10 1.53853071915627e-08 1185 1318.09090909091 1238 5.21147797238052e-11 160 1.92886936539197 2.12047167123581 1 17.8522433793645 1184 522 160 554 1238 2275 1972 2825 1568 378 1823 1024 M15651 GO_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a T cell. 17/50 Gene Ontology BP GO:0002456 2.67549833172521e-06 8.71743070470187e-06 3185 1891.09090909091 1239 2.43227416863594e-07 617 1.67126380489541 -1.12978128406346 -1 10.017058430363 3181 830 1246 1134 1332 4612 4596 866 617 1239 1149 1025 M16261 GO_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. 70/170 Gene Ontology BP GO:0030217 2.31686844607663e-07 1.94997013488455e-06 2120 1651.18181818182 1241 2.10624426370108e-08 226 1.49428649551233 1.81518777566689 1 10.1075496333559 2118 890 941 226 350 4469 3436 2023 1241 669 1800 1026 M11066 GO_RESPONSE_TO_PHENYLPROPANOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PHENYLPROPANOID.html Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. 5/17 Gene Ontology BP GO:0080184 0.000663563269227402 0.0010290328186449 990 1630.90909090909 1243 6.63761494833637e-05 732 2.94763001384881 -2.94763001384881 -1 10.4320390478648 990 1725 3682 1718 2855 1175 1243 951 732 1085 1784 1027 M12292 GO_KIDNEY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. 15/30 Gene Ontology BP GO:0061440 0.000237105833341631 0.000398870429059852 630 1381.45454545455 1243 2.15573992153684e-05 514 2.53174270982925 3.07900062879068 1 10.1946013584428 629 832 514 1243 3014 1573 1952 1803 1216 709 1711 1028 M14598 GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. 15/30 Gene Ontology BP GO:0061437 0.000237105833341631 0.000398870429059852 630 1382.45454545455 1244 2.15573992153684e-05 515 2.53174270982925 3.07900062879068 1 10.1946013584428 630 833 515 1244 3015 1574 1953 1802 1217 712 1712 1029 M10050 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. 22/50 Gene Ontology BP GO:0048008 2.54115476957958e-06 8.44913067604104e-06 535 1105.81818181818 1246 2.31014336799714e-07 82 1.22793040220509 1.2077911654187 1 7.37959807734604 535 1410 1568 1246 1307 166 82 393 3383 1810 264 1030 M12343 GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. 31/66 Gene Ontology BP GO:1900024 1.06524423672909e-07 1.2747239667869e-06 1250 1167.81818181818 1246 9.68403898462205e-09 129 1.37303276615858 1.56408802112854 1 9.5876479042564 1246 278 1222 525 129 1981 1277 1570 1165 1332 2121 1031 M10669 GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epidermis development. 39/90 Gene Ontology BP GO:0045682 3.57023467238909e-07 2.49281718252034e-06 3290 1891.54545454545 1247 3.2456684107082e-08 355 2.67053568270816 3.31398176583968 1 17.726421126741 3290 1247 482 695 488 4542 3814 2161 355 628 3105 1032 M12883 GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS.html The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 13/31 Gene Ontology BP GO:0009072 1.3522415630298e-05 3.18865290865788e-05 890 1288.72727272727 1248 1.22931806793197e-06 531 1.70037009523452 -1.85538198516183 -1 9.0570281680778 889 1199 1838 2152 1848 531 758 1351 1364 1248 998 1033 M13807 GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. 50/130 Gene Ontology BP GO:0050728 2.75899087407595e-07 2.13856337701747e-06 975 1259.90909090909 1248 2.508173836434e-08 408 1.40898012513794 1.72098779160049 1 9.46360480589431 971 656 1501 2070 408 1248 764 938 2665 1355 1283 1034 M12859 GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT.html The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. 19/54 Gene Ontology BP GO:0048566 1.68598091228556e-07 1.63000144291059e-06 2360 1896.18181818182 1249 1.5327100377196e-08 247 1.84662489296701 1.96320473862977 1 12.6610914705622 2356 1100 823 1249 247 3587 3829 3632 990 749 2296 1035 M16135 GO_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOCLAST_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. 29/50 Gene Ontology BP GO:0030316 1.61758003098586e-06 6.14098453300682e-06 1130 1501.72727272727 1250 1.47052838212262e-07 888 1.43786296873326 1.47738154353535 1 8.87728357162166 1164 2142 2034 893 1126 1654 1250 2673 888 1566 1129 1036 M16914 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. 8/23 Gene Ontology BP GO:2000651 1.16214894692746e-06 4.90532505507653e-06 1130 1730.72727272727 1252 1.16214955469348e-07 87 2.6707660030338 2.58049129807786 1 16.7978538287903 1129 1719 4636 831 1038 1444 982 4156 87 1764 1252 1037 M16936 GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 24/58 Gene Ontology BP GO:0002067 4.30637466692174e-07 2.70268065982377e-06 3405 1751.27272727273 1252 3.9148868271548e-08 247 2.01057143216645 -1.54277772575154 -1 13.262115038542 3403 1252 965 611 586 2973 3481 1786 247 847 3113 1038 M10207 GO_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION.html The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. 22/80 Gene Ontology BP GO:0051899 2.24241530438342e-06 7.74667727548527e-06 2470 1706.09090909091 1253 2.0385614454864e-07 543 2.09647018391804 2.69177198807017 1 12.692956858555 2468 994 982 654 1253 3134 1865 3680 543 970 2224 1039 M12439 GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 21/63 Gene Ontology BP GO:0010464 1.56367747901898e-05 3.61561480830933e-05 1315 1254.54545454545 1253 1.42153508469324e-06 644 1.64947192703703 1.8115635668525 1 8.67927982396028 1312 688 1661 1109 1886 1253 671 1086 644 2217 1273 1040 M13991 GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that stops or reduces the activity of an enzyme. 416/1178 Gene Ontology BP GO:0043086 1.77301465700036e-07 1.69384918774746e-06 1760 1333.54545454545 1253 1.61183163626401e-08 259 1.64959723860412 1.8358164567631 1 11.2775940713491 1758 956 499 1204 259 2644 1738 1253 1814 638 1906 1041 M14453 GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. 13/25 Gene Ontology BP GO:0045605 2.28769943593532e-06 7.83317734590537e-06 4485 1870.36363636364 1254 2.07972892257604e-07 67 2.64778919065015 -1.57106605216834 -1 16.0157598565008 4484 592 1165 185 1264 3310 3505 680 67 1254 4068 1042 M13132 GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. 132/319 Gene Ontology BP GO:0043523 3.60752983359351e-06 1.08764681931004e-05 1065 1265.63636363636 1257 3.27957795380459e-07 815 1.70166618854598 2.14085111384454 1 10.0055619160018 1063 1462 967 815 1445 1556 1257 886 1419 2105 947 1043 M11113 GO_FERRIC_IRON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERRIC_IRON_TRANSPORT.html The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/44 Gene Ontology BP GO:0015682 0.000124957025048625 0.000222204315320094 595 1407.81818181818 1258 1.13603748184634e-05 533 1.67054811086628 -1.53172782535829 -1 7.2296302313863 591 1413 2258 1908 2483 533 813 1258 1190 2019 1020 1044 M16578 GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. 13/33 Gene Ontology BP GO:0045940 0.000114883475373741 0.000205550665187006 2430 1416.72727272727 1258 1.04444977272775e-05 470 2.13846079783621 -2.67278859041721 -1 9.34032544423082 2427 1566 786 967 2639 1437 2246 470 662 1258 1126 1045 M13154 GO_CELLULAR_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 20/64 Gene Ontology BP GO:0071320 2.28749462258712e-06 7.83317734590537e-06 720 1609 1263 2.07954272823592e-07 396 1.5059983128532 1.48666837066143 1 9.10937528105884 717 3578 1771 2670 1263 495 448 396 3049 2642 670 1046 M11264 GO_CAMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 8/17 Gene Ontology BP GO:0006171 4.31758389511404e-05 8.61105757088251e-05 310 1635.63636363636 1265 4.31766778429608e-06 211 1.77216024446095 1.77216024446095 1 8.5336636242098 310 1028 3719 1868 2228 311 211 1265 3997 2518 537 1047 M14623 GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of monocyte differentiation. 5/19 Gene Ontology BP GO:0045655 2.08829377728754e-06 7.3789558660168e-06 2020 1468.54545454545 1266 2.08829573972704e-07 99 1.58750173020285 1.87546379471739 1 9.65115546515591 2018 1131 4262 315 1266 2049 2042 597 99 1094 1281 1048 M12788 GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. 15/24 Gene Ontology BP GO:1903671 6.19274182764286e-05 0.000118276019357243 705 1542.90909090909 1267 5.62992377538906e-06 399 1.60543165138573 1.68375224781077 1 7.46865072790186 702 2893 2216 2053 2354 958 1267 399 827 2719 584 1049 M12731 GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. 95/268 Gene Ontology BP GO:0006109 2.54401996233155e-06 8.44913067604104e-06 1310 1203.18181818182 1269 2.31274809470143e-07 566 1.58289868148755 1.69741468254245 1 9.51288170935806 698 1151 1308 1062 1309 1269 1320 566 1782 2154 616 1050 M15198 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin polymerization. 47/97 Gene Ontology BP GO:0030838 2.30807228586123e-06 7.8854890531668e-06 3310 2127.81818181818 1269 2.0982497339257e-07 90 1.89066754378546 -1.58576021982969 -1 11.4296612506778 3310 659 870 90 1269 4534 3222 4136 653 944 3719 1051 M15416 GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 10/21 Gene Ontology BP GO:0009074 5.69023364445528e-05 0.000109807792232776 970 1274.81818181818 1269 5.17307347814708e-06 600 1.70037009523452 -1.85538198516183 -1 7.97530333177048 969 600 1573 1354 2281 858 1416 1842 970 891 1269 1052 M10494 GO_ENDOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. 40/73 Gene Ontology BP GO:0007032 3.694669100704e-07 2.54323684131157e-06 1210 1701.90909090909 1270 3.35879065562277e-08 485 1.0368092439431 -0.922097056195846 -1 6.87142674911911 1206 790 2889 2157 501 485 820 2475 2904 3224 1270 1053 M10663 GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. 15/30 Gene Ontology BP GO:0006656 2.3118061920038e-06 7.89243834520122e-06 3525 1794.09090909091 1270 2.10164420118351e-07 396 1.78111618564869 -1.65855618637711 -1 10.7665826318736 3525 1195 1583 750 1270 2252 2671 880 396 1012 4201 1054 M11723 GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS.html Any process that modulates levels of neurotransmitter. 88/285 Gene Ontology BP GO:0001505 6.12195158306044e-07 3.23212152206309e-06 1425 1194.54545454545 1274 5.56541207874526e-08 744 1.66908157210111 1.96364763972879 1 10.855965810831 1422 1238 754 767 744 1383 1274 1321 1652 799 1786 1055 M14082 GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 14/44 Gene Ontology BP GO:0044058 1.11640248272637e-05 2.70959578008287e-05 550 1516.36363636364 1274 1.01491649819487e-06 123 3.15656553850637 3.15656553850637 1 17.0778408511315 549 3583 1274 2076 3936 332 245 297 1641 2624 123 1056 M16172 GO_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_IMPORT.html The directed movement of amino acids into a cell or organelle. 7/29 Gene Ontology BP GO:0043090 1.45524901648163e-06 5.74551121047978e-06 1245 1427.63636363636 1275 1.45524996946987e-07 79 2.51967846793365 2.51967846793365 1 15.6426418824472 1245 1036 4523 1275 1318 1480 1585 79 725 1517 921 1057 M12075 GO_COFACTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. 15/37 Gene Ontology BP GO:0051187 5.62230117537062e-06 1.53917124747912e-05 1280 1279.63636363636 1277 5.11119594884255e-07 96 2.08207349388441 2.7707845245332 1 11.8703647639597 1277 1008 1356 473 2064 3395 1968 156 167 2116 96 1058 M14661 GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. 26/59 Gene Ontology BP GO:0050775 8.66655647658518e-06 2.19524395639853e-05 310 1125 1278 7.87871874301768e-07 287 1.54678902928898 1.58685410684057 1 8.53604711400066 309 1926 2166 1637 1713 374 287 737 1363 1278 585 1059 M15202 GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. 26/58 Gene Ontology BP GO:1901862 7.42918916355466e-05 0.000138975524924997 1350 1285 1279 6.75403641092201e-06 422 2.1786992001934 2.43925251382998 1 9.95478502563672 1350 2146 1486 983 2530 1499 881 422 640 1279 919 1060 M15745 GO_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON_REORGANIZATION.html A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. 30/107 Gene Ontology BP GO:0031532 5.58001903066143e-07 3.09534389000729e-06 1285 1533.36363636364 1281 5.07274585996591e-08 707 1.872612027957 2.30439129176712 1 12.2214172135468 2196 1167 913 835 707 3183 2132 1281 1281 1269 1903 1061 M10756 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. 44/124 Gene Ontology BP GO:0051149 1.15708595403357e-05 2.8010167281428e-05 1285 1319.27272727273 1283 1.0519018543188e-06 657 1.87461072829437 1.96201226040854 1 10.1101282105507 1283 2092 997 1495 1794 1405 1140 1526 1024 657 1099 1062 M14469 GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 49/134 Gene Ontology BP GO:0051897 7.36830568436193e-06 1.91873490142975e-05 750 1356.27272727273 1284 6.69848214784275e-07 410 1.68673648720801 1.78251394419324 1 9.42518234895111 746 2391 922 1662 1670 1037 1799 1284 2143 855 410 1063 M15540 GO_CELL_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between cells. 57/122 Gene Ontology BP GO:0007043 4.98725185443109e-07 2.89447629501544e-06 3095 1743.18181818182 1284 4.53386635000714e-08 293 2.01185959518442 -2.1829715419621 -1 13.1996491059412 3092 649 293 849 653 3090 2258 2749 1284 470 3788 1064 M12510 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. 79/170 Gene Ontology BP GO:0033135 4.58992895804407e-07 2.78730492769333e-06 1285 1387.72727272727 1285 4.17266355968693e-08 241 1.5629260520756 1.72522469782515 1 10.2845691145935 1285 2304 940 1237 614 1259 1609 2934 1504 1338 241 1065 M10726 GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 10/24 Gene Ontology BP GO:0070168 4.23199828367904e-05 8.45489157965654e-05 675 1234.45454545455 1286 3.84734517645126e-06 600 1.99676676516907 1.99676676516907 1 9.63403578086593 672 1580 1402 1286 2198 714 734 1406 932 2055 600 1066 M14356 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING.html Any cell surface receptor signaling pathway that is involved in cell-cell signaling. 24/99 Gene Ontology BP GO:1905114 2.39541038151801e-06 8.07157622232818e-06 1290 1511.45454545455 1286 2.17764817245424e-07 640 1.55683576345593 1.42376807903469 1 9.39286436525469 1286 1628 1700 1182 1286 2031 640 2765 1043 1123 1942 1067 M13574 GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 39/111 Gene Ontology BP GO:0051588 2.1685163590931e-07 1.8925604239228e-06 1030 1287.63636363636 1289 1.97137870258314e-08 331 1.74516592988503 1.85580280184369 1 11.8313618236698 1030 1323 1289 1765 331 995 893 1558 2291 1264 1425 1068 M15161 GO_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORT.html The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 24/72 Gene Ontology BP GO:0015918 4.9370988466548e-07 2.88338993019097e-06 650 1577.90909090909 1289 4.48827268600654e-08 646 2.13795878116831 1.8953050605555 1 14.0311968220931 1289 1629 795 648 646 2643 3693 2719 1483 845 967 1069 M14996 GO_DEVELOPMENTAL_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_CELL_GROWTH.html The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. 49/120 Gene Ontology BP GO:0048588 3.07064245684836e-05 6.3875416340264e-05 605 1278.27272727273 1290 2.79153210552059e-06 410 1.61729034715293 1.69952657002712 1 8.0364346523745 603 1540 1290 1749 2102 410 440 1029 2533 1593 772 1070 M10708 GO_EMBRYONIC_DIGIT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGIT_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. 30/89 Gene Ontology BP GO:0042733 1.78297994012806e-06 6.54417064190877e-06 1910 1437.45454545455 1292 1.62089216830695e-07 321 1.67922526502956 -1.76202549870745 -1 10.312504786723 1907 1477 1431 1292 1173 1167 3200 321 1230 1268 1346 1071 M16577 GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING.html The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. 29/65 Gene Ontology BP GO:0061077 3.85259785850103e-08 6.23261737178407e-07 2065 1564.54545454545 1292 3.50236175087909e-09 29 1.3845778684405 1.53451415104803 1 10.1779488740327 2062 801 2125 686 29 3284 2630 1961 1292 1169 1171 1072 M10790 GO_INDOLALKYLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLALKYLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. 6/18 Gene Ontology BP GO:0006586 0.000639098633491754 0.00099502611202502 3640 1589.90909090909 1295 6.39282509100561e-05 206 2.17344675209166 -2.17344675209166 -1 7.72968231369938 589 1587 3636 1570 2840 363 206 1057 3638 1295 708 1073 M11082 GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC.html The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. 6/32 Gene Ontology BP GO:0007271 6.99421525188989e-07 3.49403306044875e-06 2265 1887.09090909091 1296 6.99421745324797e-08 88 2.45982028730756 2.71014692372785 1 15.9004480675778 2262 615 3685 519 853 3420 3842 3691 88 1296 487 1074 M10136 GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 131/337 Gene Ontology BP GO:0046394 8.53229321876747e-07 3.9340057015628e-06 3155 2099.63636363636 1297 7.75663320714675e-08 380 1.68538866690138 1.82105535381033 1 10.7916303378256 3155 380 662 988 890 4280 3666 3710 1297 815 3253 1075 M12557 GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. 22/42 Gene Ontology BP GO:2000279 7.78852139048671e-05 0.000144996410649678 955 1669 1297 7.08072466933579e-06 431 2.47020225667828 2.68142426525674 1 11.2328056873188 954 3940 1297 2586 3479 779 484 431 1342 2304 763 1076 M11314 GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS.html Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 6/12 Gene Ontology BP GO:0050930 0.000591978442185814 0.000929508253996866 905 1837.72727272727 1298 5.92136198649233e-05 326 1.6540210079828 1.6540210079828 1 5.94034844929164 904 3235 3728 2819 2878 682 326 751 2646 1298 948 1077 M11689 GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. 131/337 Gene Ontology BP GO:0016053 8.53229321876747e-07 3.9340057015628e-06 3160 2104.90909090909 1298 7.75663320714675e-08 381 1.68538866690138 1.82105535381033 1 10.7916303378256 3156 381 663 989 891 4281 3667 3758 1298 816 3254 1078 M11991 GO_RESPONSE_TO_METHYLMERCURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METHYLMERCURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. 5/14 Gene Ontology BP GO:0051597 0.000114646357987837 0.000205205489644383 1205 1919.18181818182 1298 1.14652273121666e-05 485 2.20776032740042 -2.20776032740042 -1 9.64491954569943 1202 2453 3839 2851 3126 1232 968 485 676 2981 1298 1079 M16094 GO_SERTOLI_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. 16/26 Gene Ontology BP GO:0060008 1.52580701498902e-06 5.92830290426278e-06 1300 1444.81818181818 1298 1.38709824837403e-07 560 2.23886695473088 2.18118203913308 1 13.8632360913334 1298 1192 740 1521 1099 2086 1649 2869 560 589 2290 1080 M13978 GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 42/103 Gene Ontology BP GO:0061178 1.62065032304741e-05 3.72508883658867e-05 230 1250.45454545455 1300 1.47332932894623e-06 179 1.32902230500925 1.46914506412823 1 6.97272518596924 229 2187 1739 1300 1900 262 179 636 2827 1861 635 1081 M14931 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. 20/60 Gene Ontology BP GO:0035088 2.94322452954559e-07 2.20765613742814e-06 3435 2149.36363636364 1300 2.6756590211808e-08 230 1.62777685378887 -1.48268893423061 -1 10.906554387405 3435 815 1300 795 430 4511 4319 3084 230 1135 3589 1082 M16705 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. 24/61 Gene Ontology BP GO:0002763 1.81930342946184e-06 6.63552696228699e-06 1145 1369.36363636364 1300 1.65391357631606e-07 846 1.87873581429865 -1.99598222684819 -1 11.5243449096182 1625 2346 1144 1532 1180 1141 1300 975 1552 846 1422 1083 M15632 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. 20/60 Gene Ontology BP GO:0061245 2.94322452954559e-07 2.20765613742814e-06 3440 2148.72727272727 1301 2.6756590211808e-08 231 1.62777685378887 -1.48268893423061 -1 10.906554387405 3436 816 1301 796 431 4512 4320 3065 231 1138 3590 1084 M11276 GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. 9/32 Gene Ontology BP GO:1901385 1.08292852298153e-05 2.64316497286003e-05 1240 1471.09090909091 1303 1.08293380032156e-06 71 2.34376800600702 3.36732508591272 1 12.710325276508 1238 1441 3721 1040 1799 1918 1644 814 71 1193 1303 1085 M13498 GO_CELLULAR_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. 6/21 Gene Ontology BP GO:0006883 7.62515385161587e-06 1.97454485962367e-05 3230 1844.27272727273 1304 7.62518001607929e-07 187 1.6923581480732 -1.95567704460051 -1 9.43163140178835 3230 1031 4087 759 2062 2599 3927 187 206 1304 895 1086 M12126 GO_MELANIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. 5/18 Gene Ontology BP GO:0006582 4.10938195844876e-07 2.61980478260637e-06 920 1417.90909090909 1305 4.10938271836486e-08 41 1.74913134631479 -1.74913134631479 -1 11.5656319971376 918 346 3854 1686 2624 1305 1541 41 319 1974 989 1087 M14103 GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 14/30 Gene Ontology BP GO:0018146 4.83021821530141e-06 1.36415469426061e-05 950 1172.27272727273 1305 4.39111710939786e-07 318 2.01753568635484 2.27799317038786 1 11.6277124419394 947 318 785 1599 1547 1366 1078 1325 1305 1395 1230 1088 M12601 GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 278/886 Gene Ontology BP GO:0032870 3.51301768770635e-08 5.93125131782567e-07 1310 1256.72727272727 1307 3.19365249436649e-09 227 1.74493253909719 1.85197504076525 1 12.8713869471619 1307 1056 227 263 594 2102 1696 2992 1802 437 1348 1089 M16430 GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. 41/80 Gene Ontology BP GO:0043525 0.000127475974718321 0.000226163909292 700 1844.27272727273 1308 1.15893965216027e-05 486 2.06696348485303 2.21982717474198 1 8.92641479410658 699 4029 1938 3285 2913 1080 569 486 1308 3262 718 1090 M10188 GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 15/42 Gene Ontology BP GO:0052646 7.83359689076205e-06 2.01839014227571e-05 525 1374.63636363636 1310 7.1214770765383e-07 525 1.69651134233767 -1.69651134233767 -1 9.43560854741007 525 2729 1976 1786 1685 579 647 894 1310 2107 883 1091 M13311 GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 16/23 Gene Ontology BP GO:0035729 2.62319430935244e-07 2.07508518573853e-06 1850 1312.18181818182 1310 2.38472238375633e-08 394 2.11051856185794 1.89415215040485 1 14.2083005960943 1848 822 1149 440 394 1936 1310 1777 1082 1618 2058 1092 M14628 GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that modulates the frequency, rate or extent of lamellipodium organization. 34/81 Gene Ontology BP GO:1902743 2.15776232715412e-06 7.57828327154054e-06 1310 1503.36363636364 1310 1.96160403953873e-07 731 1.54735210948367 1.45466185722901 1 9.3858484547696 1310 905 1479 731 1232 1658 863 3016 1091 1577 2675 1093 M13705 GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 16/23 Gene Ontology BP GO:0035728 2.62319430935244e-07 2.07508518573853e-06 1850 1310.54545454545 1311 2.38472238375633e-08 395 2.11051856185794 1.89415215040485 1 14.2083005960943 1849 823 1150 441 395 1937 1311 1749 1083 1619 2059 1094 M13480 GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. 20/47 Gene Ontology BP GO:0000038 2.83731972719628e-06 9.08529344370504e-06 1155 1509.63636363636 1312 2.57938489678908e-07 248 1.68052768949898 -1.12608860881354 -1 10.0368479613306 1155 821 2122 1312 1358 700 406 4243 248 2644 1597 1095 M14668 GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. 134/297 Gene Ontology BP GO:2001234 1.72091493038613e-06 6.39323889408018e-06 2055 1669.09090909091 1313 1.56446934231444e-07 890 1.63274772868136 1.88261620390089 1 10.0466759837837 2053 1313 1086 1238 1158 3251 2420 1022 2162 1767 890 1096 M15858 GO_TRYPTOPHAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRYPTOPHAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. 6/13 Gene Ontology BP GO:0006568 0.000639098633491754 0.00099502611202502 590 1668 1314 6.39282509100561e-05 207 2.17344675209166 -2.17344675209166 -1 7.72968231369938 590 1588 4467 1571 2841 364 207 1058 3639 1314 709 1097 M11591 GO_IRON_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_TRANSPORT.html The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/73 Gene Ontology BP GO:0006826 7.49468849308635e-06 1.94926418170663e-05 905 1399.09090909091 1315 6.81337638653449e-07 710 1.48840289407411 -1.3721702511426 -1 8.30484150670034 903 1168 2227 2119 1672 710 933 1477 1315 1562 1304 1098 M16162 GO_ACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase (MAPK). 78/224 Gene Ontology BP GO:0000187 5.6178252746851e-07 3.10518604170987e-06 3510 2368.27272727273 1315 5.10711519020844e-08 550 1.696281626265 1.80900542853116 1 11.0678436656695 3508 1315 943 550 710 4314 4135 4143 1103 1079 4251 1099 M13685 GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of epidermis development. 18/47 Gene Ontology BP GO:0045684 2.27522618180917e-07 1.93897835186519e-06 3420 1701.63636363636 1316 2.06838765191969e-08 342 2.22008614162473 -1.88073711547632 -1 15.0234108815608 3417 1101 1012 1316 342 1998 3060 2019 729 954 2770 1100 M14465 GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. 4/18 Gene Ontology BP GO:0033604 3.81657837676042e-06 1.13446692722783e-05 785 1334.72727272727 1316 3.81658493159799e-07 38 3.53648509439499 3.53648509439499 1 20.7173629990263 782 1876 4240 173 1501 1789 1316 192 38 1709 1066 1101 M14860 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. 24/61 Gene Ontology BP GO:0030857 2.5830322856527e-06 8.51776910673686e-06 3935 2071.18181818182 1319 2.34821392582756e-07 134 2.53467163724886 -1.93327568823001 -1 15.2222834273861 3934 287 955 341 1319 4618 3851 2447 134 1124 3773 1102 M15186 GO_ENDOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_SYSTEM_DEVELOPMENT.html Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. 54/165 Gene Ontology BP GO:0035270 6.43182870763963e-07 3.33292195196103e-06 1845 1391.81818181818 1319 5.84711871638469e-08 540 1.84223387717792 2.11681484114232 1 11.9530685654063 1845 2184 597 933 768 2440 1931 540 1314 1319 1439 1103 M15939 GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS.html The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. 8/15 Gene Ontology BP GO:0003222 4.93112138771469e-06 1.3867472200581e-05 1320 1456 1319 4.93113232993002e-07 163 2.61789028344619 3.05980395603307 1 15.0656282156722 1319 1212 4482 697 1584 2111 2117 337 234 1760 163 1104 M11807 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. 18/47 Gene Ontology BP GO:0010881 0.000169196656956237 0.000291820237090567 670 1438.18181818182 1321 1.53826973510399e-05 369 1.95763090363559 2.0149859188651 1 8.19754981500163 669 2155 1626 1321 3004 465 369 1294 1466 3017 434 1105 M14188 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 68/153 Gene Ontology BP GO:0007179 2.74390370280629e-06 8.87801037779068e-06 895 1433.72727272727 1321 2.49446102280765e-07 892 1.89583403859968 2.19786210938964 1 11.3452627971537 892 2945 1240 1419 1341 1764 1151 941 1321 1281 1476 1106 M11265 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. 45/105 Gene Ontology BP GO:1901606 7.49813876486761e-06 1.94926418170663e-05 1325 1460.36363636364 1322 6.81651301862064e-07 794 1.70742759319215 -1.88388414158752 -1 9.52693384998418 1322 1543 1153 1899 1675 794 1547 1277 2488 1067 1299 1107 M13731 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of phagocytosis. 33/79 Gene Ontology BP GO:0050766 1.60844108526383e-06 6.11128638206215e-06 755 1308.09090909091 1325 1.4622202374652e-07 621 2.03759679030571 1.91247897141017 1 12.585088398535 755 1325 621 1443 1124 1145 1242 1399 2140 1466 1729 1108 M10667 GO_MEMBRANE_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. 16/45 Gene Ontology BP GO:0044091 4.01892317052476e-07 2.61980478260637e-06 2315 1371 1326 3.65356718608646e-08 62 1.68590428399359 1.96777034517038 1 11.1475610255442 2315 310 1326 532 553 2688 2431 1534 62 802 2528 1109 M14963 GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. 12/24 Gene Ontology BP GO:1903672 5.96941197927919e-06 1.61892405489447e-05 955 1336.72727272727 1327 5.42675288778056e-07 159 1.81564923462263 1.98047848056672 1 10.304231862183 955 2357 1327 1547 2485 1030 796 159 1461 1659 928 1110 M16427 GO_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATED_EXOCYTOSIS.html A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. 122/351 Gene Ontology BP GO:0045055 2.64709432320033e-06 8.66746046729135e-06 935 1590.18181818182 1327 2.40645228023177e-07 640 1.55963542619475 1.61024602949967 1 9.35260370964213 934 1066 640 1825 1327 1349 994 3044 3016 823 2474 1111 M14169 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. 10/21 Gene Ontology BP GO:0045986 2.53320920923496e-06 8.44342452152039e-06 1085 1322.54545454545 1329 2.30292011465957e-07 178 2.06990532439466 2.06990532439466 1 12.4404071728186 1085 602 1525 1611 1305 1317 1329 1511 2011 2074 178 1112 M16443 GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. 22/48 Gene Ontology BP GO:0035924 4.02898254503738e-07 2.61980478260637e-06 1330 1248.36363636364 1330 3.66271207535235e-08 555 1.53658938814667 1.53442306795612 1 10.1602587330075 678 1330 1072 881 555 1708 1365 1590 1395 1328 1830 1113 M12038 GO_SPECIFICATION_OF_SYMMETRY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_SYMMETRY.html The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 76/206 Gene Ontology BP GO:0009799 4.00740930445065e-07 2.61980478260637e-06 1450 1311.72727272727 1334 3.64310003129123e-08 399 1.56125570953958 1.54411683915857 1 10.3233577695874 1450 399 1090 664 551 1979 1334 2466 1669 865 1962 1114 M10905 GO_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSPORT.html The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 218/695 Gene Ontology BP GO:0030001 5.80990090975802e-09 1.26053130486012e-07 1335 1278.36363636364 1335 5.28172811372833e-10 24 1.66145253237562 1.75331134711113 1 13.5793889772521 1335 24 194 901 154 2347 2210 3194 1843 54 1806 1115 M11178 GO_REGULATION_OF_HORMONE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_LEVELS.html Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 229/704 Gene Ontology BP GO:0010817 1.28142693729294e-06 5.27452594844956e-06 1340 1324.09090909091 1336 1.16493425789289e-07 318 1.6569851350933 1.83946785323125 1 10.3597896060512 1336 1231 318 866 1225 1752 1455 2580 1916 389 1497 1116 M12554 GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. 11/26 Gene Ontology BP GO:0051447 2.71267875569078e-06 8.80766955431628e-06 2225 1471.09090909091 1336 2.46607463684233e-07 474 1.45596228521502 -1.69171266554151 -1 8.7188909113454 2225 474 1981 1054 1336 1210 634 2849 1166 1537 1716 1117 M14792 GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neuron migration. 9/24 Gene Ontology BP GO:2001224 4.33632991712494e-07 2.70268065982377e-06 1745 1676 1336 4.33633076329424e-08 633 1.84742590577421 2.26337419098348 1 12.1859756988551 1741 2038 4292 1198 633 2073 1336 1640 1245 1208 1032 1118 M15784 GO_REGULATION_OF_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_CONDUCTION.html Any process that modulates the frequency, rate or extent of cardiac conduction. 31/91 Gene Ontology BP GO:1903779 3.18598858983551e-05 6.57738773793076e-05 500 1458.09090909091 1336 2.89639520864838e-06 386 1.31593273993226 1.24660274399425 1 6.51913778433674 496 1623 1374 1278 2121 386 767 2711 3160 1336 787 1119 M10923 GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. 15/56 Gene Ontology BP GO:0045762 2.57270950648049e-05 5.51736269680782e-05 670 1439.09090909091 1337 2.33885417507553e-06 468 1.36657597571261 1.50449678387692 1 6.89357993259279 667 1266 1337 1648 2034 539 686 1844 3230 2111 468 1120 M12748 GO_REGULATION_OF_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 179/457 Gene Ontology BP GO:0090087 2.61087865010219e-06 8.57306193240768e-06 1340 1436 1339 2.37352886236507e-07 794 1.57991043621411 1.66067908474417 1 9.48308718500555 1339 1781 944 1417 1324 1071 1498 2497 1995 794 1136 1121 M12949 GO_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 69/175 Gene Ontology BP GO:0051591 1.86319823426438e-06 6.75677226122619e-06 2395 1788.36363636364 1339 1.69381801111298e-07 435 1.94286395341388 2.02444553494432 1 11.8996140196954 2395 531 435 838 1190 3327 2792 2573 1339 764 3488 1122 M14102 GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 37/103 Gene Ontology BP GO:0045912 6.57585235304514e-06 1.74466757001078e-05 545 1432.72727272727 1340 5.97806546227869e-07 168 1.67428790731531 1.67428790731531 1 9.43754046063082 541 2543 1340 2196 2128 909 534 168 2388 2635 378 1123 M12022 GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS.html The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. 6/15 Gene Ontology BP GO:0048703 0.000442389404865119 0.000707548745018515 1345 2035.72727272727 1341 4.42477498321633e-05 689 1.89770420604488 1.89770420604488 1 7.08191421031223 1341 2078 3842 2998 4033 1025 835 689 1290 3120 1142 1124 M10054 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. 32/82 Gene Ontology BP GO:0030858 6.73046416766968e-07 3.41898743221995e-06 1640 1502.90909090909 1344 6.11860566065703e-08 517 1.42887634962083 -1.43936338033055 -1 9.25231567103296 1640 797 1692 3152 792 517 1344 1231 3065 1430 872 1125 M15486 GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. 22/71 Gene Ontology BP GO:0035914 2.78743844915898e-06 8.99530615964832e-06 2615 1677.36363636364 1344 2.53403816445316e-07 261 2.31549895267901 2.84977467169826 1 13.8410332280347 2613 1630 872 870 1344 3799 3731 1476 261 704 1151 1126 M16485 GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin receptor signaling. 33/96 Gene Ontology BP GO:0046626 1.78718019815687e-06 6.54923256514786e-06 875 1529.36363636364 1346 1.62471059089331e-07 528 1.67324331270715 1.63909482554272 1 10.275102647282 875 2587 1587 2221 1175 975 909 1346 2282 2338 528 1127 M12706 GO_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_REMODELING.html The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. 34/78 Gene Ontology BP GO:0046849 6.22294422506782e-06 1.67205613639988e-05 1120 1337 1348 5.6572380249328e-07 594 1.51848474358528 1.60794311055253 1 8.59252657809017 1120 1547 1330 898 1622 1817 1323 1411 1348 594 1697 1128 M15140 GO_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHRONIC_INFLAMMATORY_RESPONSE.html Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. 12/23 Gene Ontology BP GO:0002544 2.79649506462994e-06 9.00424867203664e-06 1615 1245.63636363636 1348 2.54227147214233e-07 461 1.81839707501005 1.83690531063991 1 10.8686471523072 1613 843 855 1129 1348 1739 1818 1821 461 540 1535 1129 M12078 GO_VENTRAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. 16/71 Gene Ontology BP GO:0021517 0.000256845197053102 0.000428198294404866 800 1448.90909090909 1349 2.33522898246526e-05 292 2.06521511378134 1.98731883757098 1 8.24064438382416 797 2435 1349 2078 3474 746 292 739 1918 1615 495 1130 M13412 GO_CARDIOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. 5/19 Gene Ontology BP GO:0010002 3.25268424221095e-06 1.00994864568107e-05 1355 1540.54545454545 1352 3.2526890032004e-07 57 1.97646840991341 2.20457479132271 1 11.6967263251414 1352 617 4071 545 1441 1650 1691 3569 57 1091 862 1131 M13301 GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 13/33 Gene Ontology BP GO:0010644 6.07793283655348e-05 0.000116322515087048 3085 1930.36363636364 1353 5.52554614354628e-06 830 1.85889817191314 1.31372870583968 1 8.66373357122294 3082 1348 1119 921 2301 3344 1422 1353 830 1249 4265 1132 M10685 GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. 50/156 Gene Ontology BP GO:0045833 3.34933205516991e-08 5.73869454616986e-07 4525 2059.81818181818 1354 3.04484736923722e-09 17 1.91962368229092 2.04894353027243 1 14.19257954476 4525 972 877 111 17 2502 4388 2675 632 1354 4605 1133 M16466 GO_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION.html Long distance growth of a single axon process involved in cellular development. 19/63 Gene Ontology BP GO:0048675 0.00068671492469516 0.00106209773329768 325 1520.72727272727 1354 6.24481247065966e-05 323 1.74586213245773 1.86479654320802 1 6.15042139415721 323 1488 1354 2401 3284 574 508 761 2449 2563 1023 1134 M10509 GO_RESPONSE_TO_ESTRADIOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTRADIOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 82/226 Gene Ontology BP GO:0032355 1.10905202560269e-08 2.22914656055121e-07 1360 1297.45454545455 1356 1.00822911926689e-09 65 2.10992070470085 2.4602864391192 1 16.6259848980605 1356 65 208 230 1392 3022 3191 1759 996 399 1654 1135 M11901 GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of cell proliferation. 449/1274 Gene Ontology BP GO:0008284 7.33342093150117e-13 3.09537030772363e-11 1445 1205.81818181818 1356 6.66674630136692e-14 76 1.80503794232949 1.96397222149742 1 22.4717902695921 1443 954 101 583 349 2660 2443 1356 1708 76 1591 1136 M15435 GO_CELLULAR_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. 283/767 Gene Ontology BP GO:0055082 4.45161678824333e-07 2.74343418554066e-06 1275 1652.63636363636 1356 4.04692517182854e-08 290 1.60075028033895 1.67074729171116 1 10.5465302830468 1273 870 290 1356 688 2398 2229 3960 2718 368 2029 1137 M16286 GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. 40/98 Gene Ontology BP GO:0003143 1.42153976621726e-06 5.6622369552097e-06 1555 1251.81818181818 1356 1.2923097134112e-07 286 1.82980856583031 2.13040061418435 1 11.3735423191504 1427 982 1013 286 1073 2341 1551 1552 1356 826 1363 1138 M14645 GO_LEUKOCYTE_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CELL_CELL_ADHESION.html The attachment of a leukocyte to another cell via adhesion molecules. 152/415 Gene Ontology BP GO:0007159 3.84041975404225e-07 2.57804519639595e-06 2210 1580 1357 3.49129129494864e-08 292 1.71351373109648 2.11318978306574 1 11.3442858139258 2206 1460 292 484 517 4507 3155 848 1357 455 2099 1139 M16208 GO_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 56/135 Gene Ontology BP GO:0006970 1.66354601237938e-07 1.61925453573951e-06 2060 1323.27272727273 1357 1.51231467106331e-08 113 1.77122920494807 2.07024378810389 1 12.1501807252179 2057 1077 894 113 243 2789 2488 1357 1433 547 1558 1140 M16662 GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. 2/12 Gene Ontology BP GO:0042487 0.000138919776857001 0.000244319895434491 1025 1826.5 1357.5 1.54364838676959e-05 34 5.18989204084989 5.18989204084989 1 22.2069586498401 1025 2531 4599 NA 3549 1447 1268 531 34 2298 983 1141 M11988 GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. 47/117 Gene Ontology BP GO:0030004 3.00275040909423e-06 9.50359246722872e-06 1360 1313.36363636364 1358 2.72977682501428e-07 466 1.6693255625952 -1.58668052759994 -1 9.93128585986091 1358 1921 1379 1524 1375 828 2064 466 1195 1171 1166 1142 M13752 GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of chemokine production. 36/101 Gene Ontology BP GO:0032722 6.76420348337148e-07 3.42862410188797e-06 4065 2256.18181818182 1362 6.14927778465457e-08 794 1.57454461019873 1.49268957567208 1 10.1932726210906 4065 985 1110 1098 794 3968 3510 2166 1176 1362 4584 1143 M10375 GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-alpha-amino acid across a membrane. 10/33 Gene Ontology BP GO:1902475 2.03696930642281e-05 4.51223687486695e-05 1195 1337.45454545455 1363 1.85180742442463e-06 270 1.94643025628615 1.94643025628615 1 10.0199933746881 1194 1579 1717 1646 2489 1551 1058 270 578 1363 1267 1144 M13125 GO_MIDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). 68/187 Gene Ontology BP GO:0030901 2.90150912089437e-06 9.25254591230259e-06 1045 1346.54545454545 1363 2.6377390432803e-07 1043 2.07286630173615 2.14138780833927 1 12.3606129079445 1043 1242 1218 1174 1363 1474 1701 1492 1095 1567 1443 1145 M11102 GO_PENTOSE_PHOSPHATE_SHUNT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_PHOSPHATE_SHUNT.html The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. 5/16 Gene Ontology BP GO:0006098 0.00176382898529638 0.00255441608818812 600 2020.54545454545 1365 0.000176523054292836 322 0.751494248885936 -0.751494248885936 -1 2.30811325174681 596 1365 3691 2272 3049 521 322 1306 3654 4244 1206 1146 M14737 GO_RESPONSE_TO_PARATHYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PARATHYROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. 11/27 Gene Ontology BP GO:0071107 4.40863797314507e-05 8.77381316301438e-05 1115 1514.72727272727 1365 4.00793301952888e-06 254 2.21302858388865 1.92075717174165 1 10.6353037395436 977 1113 1113 964 2209 1365 1709 3177 254 2242 1539 1147 M14377 GO_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_FORMATION.html Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. 80/190 Gene Ontology BP GO:0035148 1.79385088199179e-07 1.70831545358101e-06 1685 1609.09090909091 1366 1.63077366205458e-08 260 1.39487103396124 1.34450501120195 1 9.53003637496489 1681 396 1366 389 260 2573 1680 4641 1232 696 2786 1148 M15624 GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. 293/689 Gene Ontology BP GO:0071900 1.34758163693119e-06 5.44314265028097e-06 1690 1473.09090909091 1367 1.22507496579605e-07 404 1.6115784300039 1.7705253026658 1 10.0498077576402 1690 1367 496 1042 1056 2813 2529 2022 1624 404 1161 1149 M16440 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. 39/112 Gene Ontology BP GO:1901019 1.31275773305747e-07 1.42077719221115e-06 1635 1246.81818181818 1368 1.19341619217345e-08 175 1.82289387949604 2.10840200670869 1 12.627219553943 1631 984 994 447 175 1805 1647 1991 1407 1266 1368 1150 M14232 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. 515/1312 Gene Ontology BP GO:1902533 2.79859364376163e-07 2.15487069452492e-06 1240 1611 1369 2.79859399620737e-08 105 1.59037429348385 1.70405368341188 1 10.6757479530082 1236 1226 4210 862 444 2325 2112 1899 1933 105 1369 1151 M16107 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 559/1448 Gene Ontology BP GO:0051241 2.59944717037337e-08 4.62422728430788e-07 865 1371.54545454545 1369 2.59944720078044e-09 61 1.74799056851271 1.95902606881682 1 13.1178018012482 862 357 4509 678 726 1673 1552 1369 1884 61 1416 1152 M11296 GO_INORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSPORT.html The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 33/147 Gene Ontology BP GO:0015698 5.99242776695127e-08 8.80184804655099e-07 1675 1472.27272727273 1372 5.44766175470441e-09 51 1.55402046620273 1.44170918002779 1 11.1475513362775 1673 426 1372 2185 51 1835 1613 3623 1172 904 1341 1153 M14269 GO_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 17/53 Gene Ontology BP GO:0033280 2.97934238316058e-06 9.45528823309268e-06 1225 1528.45454545455 1372 2.70849674357485e-07 468 2.18895346731085 2.20002861487096 1 13.0284370478386 1225 1491 548 1568 1372 2639 3229 1763 1288 468 1222 1154 M14935 GO_GLIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. 5/16 Gene Ontology BP GO:0021781 7.96320207486386e-05 0.000147656338792304 1105 1605.63636363636 1372 7.96348744589904e-06 37 2.88403511412533 2.88403511412533 1 13.0876647676256 1101 1999 4320 807 2399 1372 1033 1915 37 1983 696 1155 M13005 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 105/299 Gene Ontology BP GO:0051924 2.11915936956024e-07 1.8777207925321e-06 1130 1369.36363636364 1374 1.92650870335382e-08 319 1.5761494936786 1.76671528650523 1 10.6918970646923 1130 2049 689 982 319 1436 1374 2093 2657 648 1686 1156 M16599 GO_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 114/278 Gene Ontology BP GO:0030098 4.72057155271767e-07 2.82079970646952e-06 2740 1875.45454545455 1374 4.29142960510708e-08 276 1.62035625758535 1.98773183353894 1 10.6525209474442 2737 1374 702 276 631 3862 4024 2837 1238 733 2216 1157 M13800 GO_MAINTENANCE_OF_CELL_NUMBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_NUMBER.html Any process by which the numbers of cells of a particular type in a tissue are maintained. 94/209 Gene Ontology BP GO:0098727 2.84797184988419e-07 2.17485745049544e-06 2895 1847.45454545455 1376 2.58906565323956e-08 417 1.86344027596679 2.03387763042382 1 12.4999145417525 2892 1376 918 931 417 3997 2418 3301 1231 975 1866 1158 M16196 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. 56/124 Gene Ontology BP GO:0033138 6.45918155732518e-07 3.34274494872662e-06 1350 1622.36363636364 1376 5.87198495794205e-08 455 1.54964087094912 1.77158817175029 1 10.0522745726579 1348 3307 1376 2184 770 1291 1105 3151 1417 1442 455 1159 M11277 GO_PH_REDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PH_REDUCTION.html Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. 24/49 Gene Ontology BP GO:0045851 1.41373655076216e-05 3.30776415448723e-05 330 1219.54545454545 1377 1.28522330511029e-06 163 1.48914997207685 -1.38771798689311 -1 7.90386622271921 327 2099 1880 2353 1863 163 288 493 1377 2036 536 1160 M11378 GO_CRANIAL_NERVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 15/59 Gene Ontology BP GO:0021602 0.000150385471032572 0.000262200428841243 560 1441.27272727273 1377 1.3672341083724e-05 341 1.90270247852652 2.1673646067228 1 8.07230707636285 557 2860 1377 1934 2527 618 341 897 1893 2113 737 1161 M13195 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. 102/225 Gene Ontology BP GO:2001236 1.9805252530356e-05 4.40816384322829e-05 1855 1554.54545454545 1378 1.80049371156011e-06 639 1.56478996128775 1.87029591243743 1 8.07413928890233 1855 639 905 1378 1967 2951 2349 1048 2106 1070 832 1162 M14976 GO_FEMALE_MEIOTIC_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_MEIOTIC_DIVISION.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. 10/32 Gene Ontology BP GO:0007143 5.40796402041786e-05 0.000104971475530101 525 1306.09090909091 1379 4.91645178336073e-06 182 1.59352670666099 1.59352670666099 1 7.51109936872612 521 1439 2291 1872 2268 376 182 577 1379 2833 629 1163 M13189 GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of stem cell differentiation. 36/92 Gene Ontology BP GO:2000738 0.0197097551324568 0.0253286446388035 565 1476.63636363636 1380 0.00180805285722955 564 2.23845383543315 2.46703466240649 1 4.23315859130334 564 2308 945 1380 3388 1504 1321 1532 797 1064 1440 1164 M10784 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. 16/48 Gene Ontology BP GO:0045197 2.39993017060991e-07 1.98625236758321e-06 2005 1693.90909090909 1381 2.18175493855718e-08 275 1.55884013882595 1.80188235725879 1 10.529414030038 2002 693 1381 641 364 3024 2147 4563 275 1141 2402 1165 M10833 GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. 13/34 Gene Ontology BP GO:0031290 1.57513371121205e-05 3.63486372820953e-05 525 1255.90909090909 1381 1.43194998982533e-06 31 1.56739127369528 1.72271427460667 1 8.24310171374589 524 2227 1521 1381 2368 385 31 703 2069 1836 770 1166 M14720 GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY.html A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. 37/97 Gene Ontology BP GO:0060135 3.02866579421762e-06 9.54581402769266e-06 1785 1509.27272727273 1382 2.75333633062518e-07 596 1.92017481872004 1.44135806981954 1 11.4192795580237 1784 2138 596 1530 1382 1061 905 2915 2433 885 973 1167 M11251 GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic hydroxy compound. 212/648 Gene Ontology BP GO:1901615 1.26479832164236e-07 1.3946065100142e-06 1815 1222.90909090909 1383 1.14981672214243e-08 164 1.50466195787853 -1.44338508315571 -1 10.4372128700396 1812 222 478 1383 164 805 2512 1424 2173 745 1734 1168 M13653 GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. 12/31 Gene Ontology BP GO:0045879 0.000160554868126302 0.000277740779698369 1130 1447.54545454545 1383 1.45969624122979e-05 765 1.51288300442509 1.28098492694123 1 6.37366290926836 1127 1572 1383 1429 2551 1184 925 1866 765 1114 2007 1169 M15643 GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. 22/31 Gene Ontology BP GO:0046827 0.000202685704664995 0.000345727305936654 450 1802.63636363636 1384 1.84276709527856e-05 447 1.9563187944677 1.9563187944677 1 8.02144581308676 447 3432 1982 3486 2991 675 488 557 1384 3323 1064 1170 M10042 GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL.html A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. 25/78 Gene Ontology BP GO:0097553 1.91761500970686e-05 4.29586317034705e-05 1115 1739.27272727273 1386 1.74330156788309e-06 1096 1.81052689851541 1.90094876785352 1 9.36615155236432 1112 2974 1386 2283 1952 1352 1096 1596 2874 1183 1324 1171 M15677 GO_GANGLION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLION_DEVELOPMENT.html The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. 9/27 Gene Ontology BP GO:0061548 8.52196332490844e-07 3.9340057015628e-06 1190 1748.63636363636 1386 8.52196659298384e-08 335 1.95770492907607 1.76518802226915 1 12.5352856453781 1190 335 4438 1169 925 1386 1009 2451 2394 1925 2013 1172 M16606 GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL.html The directed movement of calcium ion into a cytosol. 25/78 Gene Ontology BP GO:1902656 1.91761500970686e-05 4.29586317034705e-05 1115 1746.18181818182 1387 1.74330156788309e-06 1097 1.81052689851541 1.90094876785352 1 9.36615155236432 1113 2975 1387 2284 1953 1353 1097 1658 2875 1188 1325 1173 M15479 GO_NEGATIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. 148/388 Gene Ontology BP GO:0007162 7.5646499517298e-12 2.72268757564972e-10 785 1265.36363636364 1388 6.87695450159619e-13 97 1.92623211817044 1.95805716353423 1 21.825879948394 785 751 120 856 1438 2255 1867 2344 1388 97 2018 1174 M16787 GO_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). 53/155 Gene Ontology BP GO:0003014 9.71425313487371e-06 2.41323046041833e-05 1755 1532.90909090909 1388 8.83117820827252e-07 474 1.70061498343524 1.69827388501577 1 9.30211353542643 748 1388 474 1118 1753 1604 1204 2671 2880 1271 1751 1175 M10051 GO_GLUCURONATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. 7/28 Gene Ontology BP GO:0019585 4.09619431839314e-08 6.53561175955304e-07 1460 1481.81818181818 1389 4.09619439389777e-09 7 2.15839927974996 2.61514199551168 1 15.8135525809712 1458 850 3525 50 37 2850 3541 1104 7 1489 1389 1176 M12693 GO_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PAIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 14/52 Gene Ontology BP GO:0048265 0.000262585283135153 0.000437140003440845 465 1332 1389 2.38742390682709e-05 464 2.28145166334762 2.28145166334762 1 9.07921612154719 464 2030 807 1920 2961 513 489 1463 2112 1389 504 1177 M14836 GO_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 65/167 Gene Ontology BP GO:0033273 1.08963019406781e-10 3.26396967164957e-09 1390 1452.72727272727 1389 9.90572903747066e-12 79 2.23327468002957 2.47552574861245 1 22.4510280122762 1389 79 143 490 1491 3407 3486 2190 1102 218 1985 1178 M14675 GO_URONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. 7/28 Gene Ontology BP GO:0006063 4.09619431839314e-08 6.53561175955304e-07 1460 1550.09090909091 1390 4.09619439389777e-09 8 2.15839927974996 2.61514199551168 1 15.8135525809712 1459 851 4270 51 38 2851 3542 1084 8 1507 1390 1179 M13528 GO_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neuroblast proliferation. 14/44 Gene Ontology BP GO:1902692 7.50580849605793e-05 0.000140352270830435 1250 1416.27272727273 1391 6.8236950784503e-06 480 1.64309443076393 1.73083072203352 1 7.49919767268739 1249 1639 2010 1188 2361 869 480 2221 1525 1391 646 1180 M16611 GO_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. 10/43 Gene Ontology BP GO:0030224 5.46003639862391e-06 1.50384851781915e-05 1290 1784.18181818182 1391 4.96368177234449e-07 153 3.31061317228526 3.31061317228526 1 18.9140871365577 1391 3811 1287 2733 3386 1580 1292 153 614 2092 1287 1181 M10701 GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that modulates the activity of a monooxygenase. 38/91 Gene Ontology BP GO:0032768 2.31987124752854e-06 7.89630384264878e-06 1700 1633.36363636364 1394 2.10897608527824e-07 859 1.91113085987662 2.37480500735592 1 11.552020699126 1696 1789 859 1376 1274 2428 2471 1394 1370 1946 1364 1182 M13964 GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. 9/36 Gene Ontology BP GO:0042430 5.62603374856194e-05 0.000108659212539821 1395 1706.36363636364 1394 5.62617618878817e-06 767 2.39735626371052 -2.17344675209166 -1 11.2573707395186 1394 1508 4167 1313 2308 802 917 2643 767 1205 1746 1183 M13561 GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 11/31 Gene Ontology BP GO:2000463 2.22428019359059e-05 4.88520952641491e-05 1395 1473.72727272727 1395 2.02209334744768e-06 610 1.38292421381064 -1.38342737980174 -1 7.06262534787253 1395 704 1456 1147 1994 1647 2741 610 1306 2237 974 1184 M10419 GO_ORGAN_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_REGENERATION.html The regrowth of a lost or destroyed organ. 58/128 Gene Ontology BP GO:0031100 1.86659435205143e-05 4.20504491827985e-05 710 1392.09090909091 1396 1.69691835399659e-06 162 1.71779914879667 1.87547230824344 1 8.90533945059024 706 2134 1318 1396 2250 1376 1763 832 1816 1560 162 1185 M14259 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. 14/47 Gene Ontology BP GO:0010574 1.06963757563404e-05 2.61937091965658e-05 1400 1195 1396 9.72402523850499e-07 303 1.57280643745035 1.62770455596487 1 8.53669384170542 638 2028 1400 1660 1775 737 303 525 1895 1396 788 1186 M16893 GO_EMBRYO_IMPLANTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_IMPLANTATION.html Attachment of the blastocyst to the uterine lining. 22/60 Gene Ontology BP GO:0007566 3.19489495098225e-06 9.94229038700441e-06 2015 1728.54545454545 1397 2.90445417336175e-07 412 2.32479061085506 2.2112688680634 1 13.7768574842032 2011 571 648 412 1397 3853 4184 2748 901 705 1584 1187 M14747 GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein depolymerization. 14/30 Gene Ontology BP GO:1901881 1.16598414759511e-06 4.91258112276232e-06 2870 1787.27272727273 1398 1.05998615050796e-07 567 1.82444481091847 -2.04649704399626 -1 11.473506229948 2867 1104 1362 1124 1003 2581 1794 2234 567 1398 3626 1188 M16198 GO_ENDOTHELIAL_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 8/17 Gene Ontology BP GO:0061154 1.88866439652824e-06 6.82417804908999e-06 710 1848 1400 1.88866600170411e-07 92 2.63294021096934 2.63294021096934 1 16.1127334463938 708 2870 4527 1791 4211 1400 1122 92 342 2545 720 1189 M15417 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. 77/211 Gene Ontology BP GO:1990267 3.25410978664416e-06 1.00994864568107e-05 1655 1517.18181818182 1401 2.95828599994611e-07 392 2.01151815326449 2.06396230916685 1 11.9041504927284 1654 1071 392 754 1401 3041 1716 3181 1202 631 1646 1190 M15697 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction. 45/122 Gene Ontology BP GO:0055117 4.99917847456986e-05 9.81445482343672e-05 695 1668.09090909091 1404 4.5448109792805e-06 507 1.71518692638569 1.63095813106718 1 8.1438859423294 692 2257 1065 1404 2245 507 732 4030 2499 2049 869 1191 M10335 GO_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMMONIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. 27/89 Gene Ontology BP GO:0060359 1.56381180782776e-07 1.56145768252566e-06 1200 1530.45454545455 1405 1.42164719907927e-08 225 1.59159455770012 1.80541646092399 1 10.9476940167292 1598 2546 927 1988 225 1591 1200 1200 2877 1405 1278 1192 M10510 GO_CORONARY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORONARY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. 27/93 Gene Ontology BP GO:0060976 0.00735129805525875 0.00991059142583228 695 1830.09090909091 1406 0.000670543449420572 691 1.8230165016906 1.88937490619124 1 4.3275756722103 691 3484 1296 2559 3349 1403 1212 1228 1911 1406 1592 1193 M13568 GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. 18/43 Gene Ontology BP GO:0048713 3.31097204167596e-06 1.02145137471771e-05 1540 1225.27272727273 1408 3.00997911332482e-07 131 3.52528130814544 4.50570101208555 1 20.8420518170633 1540 1341 1057 345 1408 1871 1420 1584 131 1877 904 1194 M14546 GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of activated T cell proliferation. 9/28 Gene Ontology BP GO:0042104 1.28252844823596e-05 3.05686837020511e-05 1410 1587.27272727273 1409 1.28253585025258e-06 270 1.85766028084765 -1.22712100352194 -1 9.9351735566281 1409 479 4250 1724 1862 650 270 3559 551 1207 1499 1195 M14556 GO_DIENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. 27/125 Gene Ontology BP GO:0021536 1.9950057205981e-06 7.14082628632173e-06 4605 2485.27272727273 1409 1.81364320883004e-07 187 2.10068516695159 2.28770057019102 1 12.8064872890062 4605 990 983 187 1207 3689 4288 4077 1295 1409 4608 1196 M15900 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein. 4/20 Gene Ontology BP GO:0042510 3.03394662686024e-06 9.55024690746582e-06 1405 1750.72727272727 1410 3.03395076904266e-07 731 1.9520357412761 -1.9520357412761 -1 11.6082902371389 1704 731 4476 2311 1410 1251 1118 1402 1738 1712 1405 1197 M14125 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that activates or increases the frequency, rate or extent of response to wounding. 85/245 Gene Ontology BP GO:1903036 5.68824496493558e-07 3.12841223324166e-06 1975 1800.27272727273 1411 5.17113312333575e-08 295 1.84137309891045 1.89107512125937 1 12.0074724486056 1971 392 295 753 724 3899 3389 3610 1411 332 3027 1198 M10254 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 52/124 Gene Ontology BP GO:1903845 2.1732893530314e-06 7.5983301702747e-06 850 1790.27272727273 1412 1.97571954539762e-07 849 1.67545415621866 1.65420304894608 1 10.160606187545 849 3958 2100 1068 1236 1905 2321 1095 1412 2506 1243 1199 M15113 GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. 52/124 Gene Ontology BP GO:0030512 2.1732893530314e-06 7.5983301702747e-06 850 1793.45454545455 1413 1.97571954539762e-07 850 1.67545415621866 1.65420304894608 1 10.160606187545 850 3959 2101 1069 1237 1906 2322 1120 1413 2507 1244 1200 M11016 GO_RESPONSE_TO_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANGIOTENSIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. 13/29 Gene Ontology BP GO:1990776 1.10775164268765e-07 1.29465148368895e-06 2605 1582.27272727273 1414 1.00704699860504e-08 134 1.63426131431386 -2.16875184909744 -1 11.3987194118417 2603 930 1582 886 134 2297 1414 1408 1107 1837 3207 1201 M11721 GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 33/133 Gene Ontology BP GO:0045913 4.58837640236738e-05 9.08866537380195e-05 1415 1662.90909090909 1414 4.17133827410571e-06 939 1.70649436601678 1.92156766688217 1 8.17006368733251 1414 2628 1310 1104 2220 1796 2273 1242 1031 2335 939 1202 M15210 GO_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS.html Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. 46/117 Gene Ontology BP GO:0050764 4.89696590981927e-07 2.87468262991078e-06 1015 1376.72727272727 1414 4.45178818166555e-08 484 2.0196658960593 1.81541172105553 1 13.2579955894726 1012 1246 484 1835 641 1414 1558 1332 2342 1429 1851 1203 M16194 GO_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TISSUE_REMODELING.html Any process that modulates the frequency, rate, or extent of tissue remodeling. 32/85 Gene Ontology BP GO:0034103 4.94911087088889e-05 9.72850202097253e-05 2075 1501.81818181818 1415 4.49929291762566e-06 1006 1.59705096804332 -1.69952383345605 -1 7.59019143530263 2073 1624 1256 1415 2243 1006 1288 1124 1826 1076 1589 1204 M13782 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. 11/24 Gene Ontology BP GO:1901018 3.40159127443431e-06 1.04524078671069e-05 655 1491.09090909091 1417 3.09236048537344e-07 127 1.33638570647051 0.957653279851712 1 7.88510550774781 651 933 1754 1575 1417 415 127 4118 2548 2239 625 1205 M10507 GO_POSITIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DEATH.html Any process that activates or increases the frequency, rate or extent of neuron death. 57/112 Gene Ontology BP GO:1901216 9.96708907424761e-06 2.46680141640361e-05 625 1710.09090909091 1420 9.06103111852871e-07 201 2.12392080144219 2.21677715058492 1 11.5935430822673 621 4373 1723 3015 1786 1032 1020 201 1420 3091 529 1206 M14997 GO_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_RESORPTION.html Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). 16/43 Gene Ontology BP GO:0045124 6.70200980091825e-05 0.00012669963968104 1425 1580 1421 6.09292179774029e-06 759 1.91484835528925 -2.14689019160183 -1 8.84031708579287 1421 1980 1414 2205 2333 884 1091 759 1737 2263 1293 1207 M15758 GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY.html Any process that initiates the activity of an inactive protein kinase. 166/415 Gene Ontology BP GO:0032147 2.23039520329695e-07 1.920433592552e-06 1555 1481.72727272727 1421 2.02763220856184e-08 312 1.54698176616024 1.59166957174724 1 10.4761349775664 1552 957 493 312 334 2892 2833 3188 1421 463 1854 1208 M10128 GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. 48/111 Gene Ontology BP GO:0043407 1.60326686190365e-06 6.10008694031111e-06 1895 1335.09090909091 1422 1.45751639117987e-07 447 1.79720453401066 2.21381665227679 1 11.1020165357965 2088 1893 1529 1790 1123 1422 789 447 753 1894 958 1209 M14397 GO_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 142/323 Gene Ontology BP GO:0006732 1.94007757514098e-06 6.98277533440277e-06 500 1646.09090909091 1423 1.76370844182471e-07 239 1.2904445035189 -1.16725951404003 -1 7.88184491838843 499 1832 2969 2976 1199 239 540 1423 2121 3625 684 1210 M12351 GO_RESPONSE_TO_TESTOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TESTOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. 24/66 Gene Ontology BP GO:0033574 0.00131097976066335 0.00193726258076382 1425 1622.09090909091 1424 0.00011925105688332 625 1.44376745240337 -1.54637811276582 -1 4.63975246036167 1424 1093 1935 2251 3648 725 625 871 2495 1485 1291 1211 M10948 GO_ROUNDABOUT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUNDABOUT_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 5/15 Gene Ontology BP GO:0035385 0.000597822723978144 0.000938367446731076 1175 1729.45454545455 1426 5.97983611300998e-05 246 4.17107737499882 4.17107737499882 1 14.9598995785672 1173 1995 3661 1834 2822 1426 853 1066 246 2971 977 1212 M12931 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. 15/35 Gene Ontology BP GO:0071634 9.63407652204339e-07 4.28458020036853e-06 1455 1395 1426 8.75825521902652e-08 62 1.83731574392903 2.36456203908958 1 11.6837367609132 1451 1762 1412 1416 1748 2310 1238 62 1047 1473 1426 1213 M10369 GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoclast differentiation. 41/137 Gene Ontology BP GO:0045670 2.34738545377234e-06 7.95540924223722e-06 1235 1452.09090909091 1427 2.13398905310986e-07 349 1.64896754435279 -1.98629238357415 -1 9.96102180221198 1234 2427 1460 1927 1280 959 2225 349 1618 1427 1067 1214 M11914 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. 13/66 Gene Ontology BP GO:0016339 4.1438869683142e-06 1.21404827899932e-05 1730 1314.27272727273 1427 3.76717706699824e-07 188 1.73283749423101 2.14820562158461 1 10.0908301048193 1726 1107 1527 1427 1493 1578 1162 1193 188 1245 1811 1215 M12360 GO_ENAMEL_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENAMEL_MINERALIZATION.html The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. 4/13 Gene Ontology BP GO:0070166 1.0750693386934e-05 2.63128462812517e-05 1825 1556.54545454545 1427 1.07507453971218e-06 519 1.38693018718312 1.5230110238034 1 7.52457835570298 1823 1042 3896 1310 1797 1563 1606 1244 519 895 1427 1216 M16539 GO_UTERUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTERUS_DEVELOPMENT.html The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. 11/24 Gene Ontology BP GO:0060065 5.72778632238786e-06 1.56435952322629e-05 1915 1465.09090909091 1427 5.20709203178059e-07 163 1.62308956732913 -1.8351046184855 -1 9.24004018733323 1911 163 1193 976 1597 1794 3608 819 1427 1550 1078 1217 M12672 GO_HIPPOCAMPUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPOCAMPUS_DEVELOPMENT.html The progression of the hippocampus over time from its initial formation until its mature state. 46/129 Gene Ontology BP GO:0021766 4.31279510940181e-05 8.60520313405785e-05 970 1507 1428 3.92079968917584e-06 595 1.64043338760841 1.77430084387506 1 7.89991973685629 812 3088 1872 2017 2203 967 958 969 1668 1428 595 1218 M10811 GO_THYMIC_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMIC_T_CELL_SELECTION.html The process of T cell selection that occurs in the thymus. 13/27 Gene Ontology BP GO:0045061 7.71755247046185e-06 1.99402315639145e-05 1050 1453.63636363636 1429 7.01598140327468e-07 178 1.48744892531827 1.61293913777752 1 8.2821456458901 1047 1429 2016 1793 2063 1834 1076 178 866 2467 1221 1219 M11681 GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 224/516 Gene Ontology BP GO:0090407 3.00200256102098e-07 2.22656515827802e-06 440 1813.09090909091 1429 2.72909360968937e-08 436 1.25174554530594 -1.15867474890912 -1 8.38154799331818 1259 2048 2908 3147 438 436 1429 1234 2924 3327 794 1220 M16598 GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 18/39 Gene Ontology BP GO:0010922 8.57996203659149e-06 2.18223556625645e-05 645 1309.27272727273 1433 7.79999590770735e-07 473 1.9396505695508 2.16219772385236 1 10.7100081266726 643 2103 1433 1926 1709 731 473 779 1442 2451 712 1221 M13093 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. 14/45 Gene Ontology BP GO:1904037 1.05768779355285e-06 4.5767422418135e-06 4545 2526.81818181818 1434 9.61534820049792e-08 779 1.92080406905439 -1.83581721673557 -1 12.149463696999 4543 928 779 1434 966 4118 3968 4535 1410 933 4181 1222 M15184 GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. 24/59 Gene Ontology BP GO:0030834 1.33990814202838e-06 5.43810620929874e-06 1550 1666.18181818182 1434 1.21809905281727e-07 871 1.56294226082588 1.30290232054926 1 9.74725677047519 1550 1403 1563 1353 1052 1434 871 3655 953 2039 2455 1223 M11144 GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. 10/23 Gene Ontology BP GO:0061099 0.00015938923427287 0.000275929983120408 1190 1810.09090909091 1435 1.44909802853481e-05 946 1.36203322207144 -1.31433646814749 -1 5.74272742090436 1188 1118 2360 1958 2549 1225 1435 946 2981 2809 1342 1224 M14879 GO_CELLULAR_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 80/199 Gene Ontology BP GO:0097306 7.62093645265223e-07 3.66370740073268e-06 950 1419.09090909091 1435 6.92812644781197e-08 328 2.11664786633116 2.13572999276672 1 13.6305204332143 946 2719 328 729 848 1907 1832 1774 2395 697 1435 1225 M14999 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. 22/62 Gene Ontology BP GO:2000649 1.10978094014258e-07 1.29465148368895e-06 2140 1523.18181818182 1435 1.00889181465912e-08 137 2.01115718612851 -1.87225227495133 -1 14.0275100994185 2138 682 1435 699 137 2069 1597 3571 602 1327 2498 1226 M13703 GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 15/45 Gene Ontology BP GO:0098815 3.16720561607553e-06 9.88438235217516e-06 2145 1557.90909090909 1436 2.87928197792471e-07 504 1.45604573869219 -1.4026279959089 -1 8.63299511829034 2144 696 1436 1141 1393 2435 2853 504 1085 1474 1976 1227 M16343 GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 18/55 Gene Ontology BP GO:0010862 6.10826341327113e-06 1.64887598998941e-05 1770 1256 1436 5.55298215711713e-07 258 1.82112779811854 2.21243560343678 1 10.3181482913919 1769 1490 1098 1436 1612 2323 927 258 576 1883 444 1228 M16931 GO_PROTEIN_HETEROOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 84/185 Gene Ontology BP GO:0051291 3.56722910159371e-06 1.078297182207e-05 3555 2018.27272727273 1437 3.24294080523079e-07 394 1.78962950426897 2.12289795991341 1 10.5307230143929 3552 394 564 1046 1437 3556 4227 2431 1090 425 3479 1229 M12118 GO_LEFT_RIGHT_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_PATTERN_FORMATION.html The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 14/39 Gene Ontology BP GO:0060972 1.99246763140967e-05 4.42421196204451e-05 1440 1956.81818181818 1438 1.81135061523853e-06 268 1.89376889211401 2.09430876759016 1 9.76809321682811 1437 4096 1991 3074 3298 1311 911 268 1438 2622 1079 1230 M12558 GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids with a chain length of less than C6. 10/26 Gene Ontology BP GO:0046459 0.00091201657552819 0.00137997952668474 680 1619.27272727273 1438 8.29449885725939e-05 227 1.08979709073927 -1.08979709073927 -1 3.69240151114717 676 1438 2670 2164 3172 445 227 1344 2046 2819 811 1231 M10407 GO_RESPONSE_TO_ORGANOPHOSPHORUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANOPHOSPHORUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. 88/232 Gene Ontology BP GO:0046683 1.21398701566518e-06 5.04162943983311e-06 1440 1339.63636363636 1439 1.10362516868967e-07 433 1.94507709596083 2.03865626052021 1 12.2061868234026 1439 529 433 930 1020 2047 1878 1901 1578 672 2309 1232 M13284 GO_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions within an organism or cell. 28/98 Gene Ontology BP GO:0055081 4.59675649308461e-06 1.31097913988894e-05 1420 1638.72727272727 1440 4.17887827066869e-07 828 1.46901997094152 1.5898036835119 1 8.49648798990771 1345 2265 1419 2175 1531 1440 1135 1418 3011 1459 828 1233 M11978 GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 113/267 Gene Ontology BP GO:0008654 2.22714751334404e-06 7.71689992869878e-06 2465 1545.09090909091 1443 2.02468160725205e-07 353 1.36590830164342 -1.28923689381772 -1 8.27251821548508 983 2002 2695 2461 1249 353 1443 366 2360 2462 622 1234 M12933 GO_ONE_CARBON_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_COMPOUND_TRANSPORT.html The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/11 Gene Ontology BP GO:0019755 3.26289586919206e-06 1.01132346599858e-05 1585 1624.63636363636 1443 3.26290066012221e-07 1011 3.59109335581366 -3.59108807873796 -1 21.2495536399298 1584 1025 3982 1030 1443 1753 2100 1011 1336 1053 1554 1235 M13011 GO_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a cell population. 391/1073 Gene Ontology BP GO:0008283 1.83847695796628e-07 1.73145000321246e-06 1745 1475.54545454545 1444 1.67134282872959e-08 269 1.73778486252505 1.92643916649515 1 11.8608661125978 1743 738 332 603 269 3603 2902 1724 1444 746 2127 1236 M12237 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. 37/95 Gene Ontology BP GO:0032024 0.00124258571698047 0.00184088241350999 865 1694.90909090909 1445 0.000113026190852796 778 1.72245852077383 2.10437071002944 1 5.58058769806276 864 3064 1552 2543 3559 881 1080 932 1946 1445 778 1237 M14252 GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. 115/250 Gene Ontology BP GO:0006575 4.16855116790985e-06 1.21726937563556e-05 1445 1394.72727272727 1445 3.78959915134984e-07 638 1.52279820558234 -1.60022354153728 -1 8.86563255616058 1445 638 1510 1740 1497 1121 2150 1197 1664 1004 1376 1238 M14020 GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 86/231 Gene Ontology BP GO:0072330 3.11833885405593e-06 9.75636610470464e-06 4440 2315.27272727273 1447 2.83485752189238e-07 705 1.69975309965314 1.91352738986169 1 10.0893527178908 4438 1070 705 1424 1390 1956 3325 3871 1393 1447 4449 1239 M16507 GO_PROTEIN_AUTOPROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPROCESSING.html Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. 10/19 Gene Ontology BP GO:0016540 3.77283207820194e-05 7.64945822667755e-05 1645 1476.81818181818 1449 3.42990616449618e-06 165 2.1505745818712 -2.18880131491892 -1 10.4868938841638 1643 165 1352 1603 2166 1449 3713 1744 865 892 653 1240 M13009 GO_TERPENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERPENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. 35/174 Gene Ontology BP GO:0006721 4.38839669726133e-06 1.26616711933525e-05 980 1297 1450 3.98945950084888e-07 138 1.7933212213358 1.86179257478759 1 10.4042638959644 978 2094 1083 1814 1907 1450 1499 138 1530 1283 491 1241 M13112 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). 31/111 Gene Ontology BP GO:0007200 3.07425696058968e-07 2.2692806149472e-06 1010 1698.45454545455 1450 2.79477944562109e-08 443 2.22439151400327 2.15235639313474 1 14.8725312342826 1009 1841 569 2263 443 1193 1521 4622 2439 1333 1450 1242 M10413 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION.html The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. 3/21 Gene Ontology BP GO:0021843 7.56242840755347e-07 3.65169588473682e-06 3100 1964.90909090909 1452 7.56243098111925e-08 3 2.96591118834833 -1.69379145427173 -1 19.1045101597091 3100 1452 3581 103 878 4300 4330 1627 3 1416 824 1243 M12174 GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of striated muscle contraction. 51/141 Gene Ontology BP GO:0006942 3.27891620165283e-06 1.01493386161827e-05 1165 1839.18181818182 1452 2.98083735328517e-07 1089 1.59004402908229 1.63095813106718 1 9.40584122064382 1165 2057 1251 1452 1403 1089 1222 3927 2612 2453 1600 1244 M15438 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. 18/30 Gene Ontology BP GO:0033137 9.57443298828881e-07 4.26622767414827e-06 1155 1344.81818181818 1452 8.70403377736268e-08 813 1.62242133386618 1.76507496174958 1 10.3207772332234 1152 828 1530 928 932 1693 1886 1452 813 1880 1699 1245 M10502 GO_FOCAL_ADHESION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOCAL_ADHESION_ASSEMBLY.html The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. 22/40 Gene Ontology BP GO:0048041 1.07911901828037e-06 4.63668460806044e-06 1455 1641.81818181818 1453 9.81017770543581e-08 973 1.78343643457899 2.18341146157146 1 11.2686472335765 1453 995 1214 1004 973 2907 2516 2298 1185 1812 1703 1246 M12613 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION.html The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. 3/21 Gene Ontology BP GO:0021826 7.56242840755347e-07 3.65169588473682e-06 3105 1997.81818181818 1453 7.56243098111925e-08 4 2.96591118834833 -1.69379145427173 -1 19.1045101597091 3101 1453 3937 104 879 4301 4331 1623 4 1418 825 1247 M16371 GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 833/2142 Gene Ontology BP GO:0051174 9.48987115583737e-08 1.19732260262372e-06 1245 1654.45454545455 1453 9.48987156109681e-09 125 1.54147732261977 1.67813994442921 1 10.8135449477097 1244 1050 4554 1567 125 2219 1868 1453 2296 441 1382 1248 M14304 GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction. 22/40 Gene Ontology BP GO:0007045 1.07911901828037e-06 4.63668460806044e-06 1455 1646.18181818182 1454 9.81017770543581e-08 974 1.78343643457899 2.18341146157146 1 11.2686472335765 1454 996 1215 1005 974 2908 2517 2333 1186 1816 1704 1249 M11493 GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 68/180 Gene Ontology BP GO:0051282 5.91382258081831e-06 1.60572387384441e-05 1160 1708.90909090909 1455 5.37621679802869e-07 1042 1.61516555875242 1.91049912672329 1 9.17324330929323 1159 2653 1238 2142 1603 1404 1042 1455 3070 1868 1164 1250 M12386 GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION.html Any process that activates or increases the frequency, rate or extent of vasoconstriction. 16/45 Gene Ontology BP GO:0045907 1.83633788766239e-05 4.1509818950421e-05 620 1421.36363636364 1456 1.66941201430566e-06 617 1.57447422008344 1.56661889948137 1 8.17280223143934 617 2223 1667 1659 1940 1456 1093 953 1386 806 1835 1251 M15753 GO_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. 218/611 Gene Ontology BP GO:0048732 8.8531753244658e-09 1.84328668302667e-07 2030 1496.63636363636 1456 8.0483412364477e-10 200 1.86725516894008 2.15229776707449 1 14.8963919273436 2028 1456 200 319 692 3526 3052 1962 963 264 2001 1252 M12982 GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. 17/32 Gene Ontology BP GO:0090049 2.79488336052437e-05 5.91460503323367e-05 880 1392.90909090909 1457 2.54083533399708e-06 363 1.45678369133196 1.54980086455838 1 7.29651833364247 876 2104 1883 1457 2067 1134 1136 363 1620 1794 888 1253 M14190 GO_POSITIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GROWTH.html Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. 157/393 Gene Ontology BP GO:0045927 5.52064478816106e-07 3.08451910366207e-06 1680 1329.09090909091 1459 5.01876924863937e-08 472 1.82996434057664 2.10847691741813 1 11.9463794533298 1678 1459 472 1222 702 2076 2255 1113 1521 595 1527 1254 M12968 GO_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 63/167 Gene Ontology BP GO:0090279 3.77653330356673e-06 1.12979665776162e-05 1255 1672.27272727273 1460 3.43321798763838e-07 1204 1.60944459775622 1.8540986045689 1 9.43182949143214 1204 2831 1254 1893 1460 1295 1252 1490 2909 1569 1238 1255 M10396 GO_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or around a point. 47/126 Gene Ontology BP GO:0009798 5.45408160923278e-07 3.05468044772832e-06 1525 1360.63636363636 1461 4.95825723760899e-08 699 2.04964581988306 2.13735795213007 1 13.3907554698378 1525 2058 733 714 699 2166 1652 1388 1061 1461 1510 1256 M11177 GO_REGULATION_OF_BODY_FLUID_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BODY_FLUID_LEVELS.html Any process that modulates the levels of body fluids. 309/777 Gene Ontology BP GO:0050878 1.08228330907269e-19 1.79465764429446e-17 790 1209.36363636364 1462 9.83893917338807e-21 27 2.03384821223941 2.0940389729936 1 40.3467154427044 789 1880 27 991 1104 1660 1462 2052 1520 144 1674 1257 M12956 GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of muscle cell differentiation. 91/264 Gene Ontology BP GO:0051147 4.66583160828886e-07 2.80251696730727e-06 1785 1599.18181818182 1463 4.24166599803083e-08 486 1.81529593984098 1.87227601294274 1 11.9401633974401 1785 1236 537 1366 627 2655 2297 3323 1463 486 1816 1258 M16502 GO_CELLULAR_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 45/137 Gene Ontology BP GO:0035690 0.000135492497552948 0.000238925813193444 930 1486.36363636364 1464 1.23182584469598e-05 502 2.01473256477999 2.37794231504911 1 8.64395156051918 926 3002 685 1464 2690 1293 1472 502 1695 1669 952 1259 M13564 GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 105/252 Gene Ontology BP GO:0010952 9.35033548771683e-07 4.2103568812085e-06 1435 1564.36363636364 1465 8.50030860159487e-08 586 1.79843159196155 1.94251835721114 1 11.4526359904104 1431 1465 694 1148 924 2815 3250 1801 1550 586 1544 1260 M12833 GO_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TASTE.html The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. 17/88 Gene Ontology BP GO:0050909 3.82562264853254e-06 1.13642776437214e-05 4640 2329.09090909091 1467 3.4778448190892e-07 456 2.17971627042059 -2.28952570370026 -1 12.7672310249395 4637 456 609 1196 1467 3582 3763 4066 1129 636 4079 1261 M12183 GO_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIVISION.html The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. 16/47 Gene Ontology BP GO:0017145 5.81304549657806e-07 3.17155937022467e-06 1985 1622.18181818182 1469 5.28458821141437e-08 626 1.60903329004357 1.5582625666045 1 10.4810606022595 1984 1419 1469 1131 722 3008 2463 2547 1670 805 626 1262 M10997 GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that activates or increases the frequency, rate, or extent of cellular extravasation. 6/16 Gene Ontology BP GO:0002693 3.48960754925537e-05 7.12813367848336e-05 945 1672 1470 3.4896623485903e-06 231 1.88314875415596 2.34804051426731 1 9.25122441080047 943 1446 3669 1643 2537 780 870 1470 2632 2171 231 1263 M10840 GO_ICOSANOID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_TRANSPORT.html The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. 7/31 Gene Ontology BP GO:0071715 0.00131398718673706 0.00194047153562983 535 1816.45454545455 1471 0.000131476478697478 268 1.59739987379694 1.59739987379694 1 5.13211215426556 532 2286 3646 2140 3169 763 268 913 3876 917 1471 1264 M13716 GO_FATTY_ACID_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_TRANSPORT.html The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/31 Gene Ontology BP GO:1901571 0.00131398718673706 0.00194047153562983 535 1860.36363636364 1472 0.000131476478697478 269 1.59739987379694 1.59739987379694 1 5.13211215426556 533 2287 4120 2141 3170 764 269 910 3877 921 1472 1265 M14328 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. 70/154 Gene Ontology BP GO:0048660 1.48152606154343e-07 1.52301086663364e-06 1475 1551.63636363636 1473 1.34684196482955e-08 207 1.88789823744829 1.99116918596501 1 13.010016983374 1473 1074 512 282 207 2923 2601 3333 1767 668 2228 1266 M12159 GO_MOTOR_NEURON_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_NEURON_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. 19/55 Gene Ontology BP GO:0008045 1.49684168343318e-05 3.47665629623824e-05 285 1197 1474 1.36077442525482e-06 94 1.64139287827006 1.64139287827006 1 8.66986388958743 281 1698 1474 1774 1874 264 94 582 2157 2558 411 1267 M10978 GO_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 52/130 Gene Ontology BP GO:0009408 0.000293577985422523 0.000484221167430471 620 1803.72727272727 1475 2.66924699201804e-05 392 1.58480583591588 1.6740535643948 1 6.22345916775719 618 3543 1475 2921 3427 392 617 956 3211 2160 521 1268 M12844 GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that activates or increases the activity of a phosphoprotein phosphatase. 13/27 Gene Ontology BP GO:0032516 8.71396805966224e-06 2.20124884118671e-05 700 1458.45454545455 1477 7.92182052269312e-07 651 1.74581271550143 1.97553719486605 1 9.63191784716074 697 2405 1477 2358 1717 724 768 1169 1600 2477 651 1269 M16601 GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 132/322 Gene Ontology BP GO:0034599 1.32808678218912e-07 1.42738586335742e-06 1480 1642.36363636364 1477 1.20735169305683e-08 179 1.61323463843833 1.92017765313512 1 11.1710543376746 1477 2382 890 1337 179 2492 2073 1825 2660 1444 1307 1270 M15928 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 13/27 Gene Ontology BP GO:0030949 2.95306524629953e-05 6.17616303539131e-05 575 1784.90909090909 1478 2.68464080555425e-06 51 1.92503932442296 1.92503932442296 1 9.59899080909564 572 4099 1478 3188 4181 293 51 386 3182 1856 348 1271 M11909 GO_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSPORT.html The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 104/370 Gene Ontology BP GO:0015849 5.90998025430369e-09 1.27628085212707e-07 2295 1864.54545454545 1481 5.37270933652725e-10 195 1.91843217937282 2.06272670209957 1 15.6674807759345 2293 877 195 784 1165 4238 3572 2843 1481 359 2703 1272 M13646 GO_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 265/645 Gene Ontology BP GO:0009314 3.82935946176464e-07 2.57804519639595e-06 1485 1378.54545454545 1481 3.48123648028179e-08 515 1.63893424597491 1.95510021538854 1 10.8505336454176 1481 1144 746 1878 515 2910 1501 715 1728 974 1572 1273 M11561 GO_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the meiotic cell cycle. 24/61 Gene Ontology BP GO:0051445 2.29445498447516e-07 1.93916799831772e-06 3495 1596.63636363636 1484 2.08586838524703e-08 291 1.79824982756346 -1.8804338395929 -1 12.1687370291866 3491 291 1651 604 347 2739 1850 1167 786 1484 3153 1274 M14288 GO_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_POLYMERIZATION.html Assembly of actin filaments by the addition of actin monomers to a filament. 20/38 Gene Ontology BP GO:0030041 0.000621972364713318 0.000971348028713063 3115 1999.36363636364 1484 5.65589340981972e-05 832 2.01063089517039 -2.31921092517155 -1 7.17555416258262 3115 1484 1085 1386 2811 3089 3931 1212 969 832 2079 1275 M11021 GO_ADULT_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_WALKING_BEHAVIOR.html The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 21/79 Gene Ontology BP GO:0007628 9.14920805548308e-06 2.2937242441473e-05 1185 1480.54545454545 1485 8.31749645890835e-07 560 2.05047550780074 2.00442797292912 1 11.2693779636768 1182 1485 1733 1466 1730 1063 560 2341 1261 1678 1787 1276 M14239 GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. 94/300 Gene Ontology BP GO:0051480 2.6368732706994e-07 2.07508518573853e-06 845 1675.90909090909 1486 2.3971578061359e-08 280 1.77842445652185 1.93263939127322 1 11.9725972393105 842 2301 280 1612 2146 1438 1235 3472 3003 620 1486 1277 M15963 GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. 5/24 Gene Ontology BP GO:0036152 6.24110509490972e-06 1.67499716506739e-05 1490 2059.81818181818 1486 6.24112262310577e-07 128 3.17112867683882 -3.17112867683882 -1 17.9413436212158 1486 3754 4488 2810 3604 1155 1095 170 128 3006 962 1278 M16566 GO_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_WALKING_BEHAVIOR.html The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 21/79 Gene Ontology BP GO:0090659 9.14920805548308e-06 2.2937242441473e-05 1735 1478.18181818182 1486 8.31749645890835e-07 561 2.05047550780074 2.00442797292912 1 11.2693779636768 1183 1486 1734 1467 1731 1064 561 2292 1262 1692 1788 1279 M12218 GO_ANATOMICAL_STRUCTURE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. 20/76 Gene Ontology BP GO:0071695 0.0123972802395845 0.0162646431625857 1070 1949.81818181818 1487 0.00113342696825137 1066 1.56470799127465 1.54862037895393 1 3.31560017969547 1066 1487 1154 2674 3399 1294 1143 2049 3783 2134 1265 1280 M14258 GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. 24/50 Gene Ontology BP GO:1901532 0.00064846879034184 0.00100764410761619 705 1559.36363636364 1487 5.89690919064126e-05 467 1.39255077023873 -1.22407420695441 -1 4.94346223259012 705 1627 1704 2319 2817 467 915 1299 2959 1487 854 1281 M10656 GO_SECRETION_BY_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION_BY_CELL.html The controlled release of a substance by a cell. 261/746 Gene Ontology BP GO:0032940 4.95122852601043e-07 2.88438570216643e-06 1500 1542.72727272727 1488 4.50111785483062e-08 336 1.68069583108966 1.87478885267678 1 11.0299296374164 1498 1058 336 1087 649 2278 1488 2727 2469 615 2765 1282 M14988 GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 18/66 Gene Ontology BP GO:0071391 7.1650122335929e-06 1.87843883684765e-05 930 1586.90909090909 1488 6.51366869898295e-07 88 2.24969768692632 2.2618029275272 1 12.5954756194552 929 2508 1370 1845 2607 535 740 1488 2322 3024 88 1283 M11471 GO_MANGANESE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_TRANSPORT.html The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/14 Gene Ontology BP GO:0006828 3.70909510011478e-06 1.1153710200669e-05 1610 1682.27272727273 1489 3.70910129095323e-07 345 1.64757937252449 -1.21963414682962 -1 9.66620336833405 1703 345 3752 1608 1489 1046 1260 3543 1064 1088 1607 1284 M12561 GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 9/50 Gene Ontology BP GO:0071378 0.00989845646583688 0.0131347623237727 1215 2095 1490 0.000994282561894257 1123 1.87083836224805 -1.87083836224805 -1 4.17000301800132 1215 2799 3931 2552 3329 1123 1490 1322 1196 2681 1407 1285 M11291 GO_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. 14/27 Gene Ontology BP GO:0055075 9.58210073941123e-08 1.20242415494828e-06 2910 1660.81818181818 1493 8.7110010515997e-09 111 1.96272604209345 -2.43504666063814 -1 13.7643341698481 2910 1497 1581 1132 111 3076 4598 190 297 1384 1493 1286 M16618 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM.html Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. 19/56 Gene Ontology BP GO:0010880 7.39447032045012e-05 0.000138486635605961 910 1580.27272727273 1493 6.72247169943556e-06 594 1.72777128308219 2.0149859188651 1 7.89756366112979 907 2063 1689 1493 2357 720 859 2130 1485 3086 594 1287 M10993 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte migration. 16/39 Gene Ontology BP GO:2000403 0.000188566659889945 0.000323545824785298 1380 1564.45454545455 1495 1.71438931161349e-05 654 1.91620255694431 2.14010624592972 1 7.92232839519056 1379 1495 752 962 2575 2531 2798 654 1727 803 1533 1288 M11703 GO_ENDOCARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. 7/14 Gene Ontology BP GO:0003157 5.95383152731751e-07 3.22186943838406e-06 3210 2022 1497 5.95383312248306e-08 614 2.01572276951075 -1.27495338520603 -1 13.1138689888101 3208 614 3791 1090 777 1428 2212 2851 1155 1497 3619 1289 M12205 GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE.html Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. 12/38 Gene Ontology BP GO:1902668 0.000813267442602835 0.00124047330354959 550 1721.36363636364 1498 7.39607487669806e-05 550 1.96890612824623 2.07722822379705 1 6.77891625787923 550 1568 611 1077 3294 1498 1302 2410 3652 1652 1321 1290 M12332 GO_CARDIAC_ATRIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_ATRIUM_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. 18/55 Gene Ontology BP GO:0003230 1.8424169146375e-05 4.16269670786468e-05 2325 1713.72727272727 1499 1.6749384948766e-06 699 2.47084969968442 3.15245329468666 1 12.8221387818263 2323 1265 801 1499 1941 2732 2429 1365 699 1343 2454 1291 M12059 GO_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 43/132 Gene Ontology BP GO:0043542 4.81900247598236e-06 1.36264485359233e-05 730 1549.63636363636 1503 4.38092093802366e-07 730 1.68840545832223 1.89618341473956 1 9.73178986543292 730 2625 964 2062 1545 1183 898 1034 2223 2279 1503 1292 M13538 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. 18/47 Gene Ontology BP GO:0055025 1.64527398344476e-05 3.77607864811369e-05 750 1650 1503 1.49571480707714e-06 749 2.31971489202713 2.57660629861253 1 12.1541771677393 749 2509 1201 2341 1904 1503 1417 1442 2026 1876 1182 1293 M16015 GO_AMINOGLYCAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 30/79 Gene Ontology BP GO:0006026 1.88936624488068e-05 4.24475095067846e-05 520 1279.81818181818 1504 1.71762042818792e-06 263 1.85360403305684 1.92392242039156 1 9.60041097386357 518 2014 1504 2796 2131 477 398 263 1581 2104 292 1294 M11815 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. 70/161 Gene Ontology BP GO:0097202 2.63828653956842e-06 8.64471729231912e-06 1450 1719.90909090909 1505 2.39844518496615e-07 811 1.73388044167225 2.01117812322655 1 10.3998357989651 1449 2008 1034 1802 1326 3137 3070 1160 1505 811 1617 1295 M10614 GO_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 202/549 Gene Ontology BP GO:0001101 2.50978396422716e-13 1.16529269459067e-11 1510 1622.81818181818 1506 2.28162178566131e-14 93 1.97887388791747 2.13597378627881 1 25.6305532769181 1506 226 93 334 1098 3580 3460 3007 1834 250 2463 1296 M12070 GO_POSITIVE_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASODILATION.html Any process that activates or increases the frequency, rate or extent of vasodilation. 12/43 Gene Ontology BP GO:0045909 1.87214580398777e-05 4.213462417797e-05 720 1550.18181818182 1506 1.70196521425197e-06 562 1.95059235650697 1.70195168921819 1 10.1101692622571 720 1709 562 1789 1946 1107 798 3172 3005 738 1506 1297 M16125 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST.html Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. 78/211 Gene Ontology BP GO:0050691 2.89029260694576e-06 9.22945569054276e-06 1875 1649.54545454545 1506 2.62754218557331e-07 689 1.76793109948446 -1.61116005562474 -1 10.5445403719834 1871 2007 1506 2977 1360 689 1933 1297 1285 2146 1074 1298 M12659 GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. 13/31 Gene Ontology BP GO:0052312 0.000147276678710272 0.000257263212660569 890 1819.45454545455 1510 1.33896853560234e-05 674 1.66230301443229 1.81657985611981 1 7.06865762209247 886 3551 2115 2637 2522 1252 1090 1510 674 2476 1301 1299 M16115 GO_MITOCHONDRION_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_DISTRIBUTION.html Any process that establishes the spatial arrangement of mitochondria between and within cells. 7/17 Gene Ontology BP GO:0048311 3.96815996939525e-05 8.00007240030488e-05 1510 1990.63636363636 1510 3.96823082949703e-06 345 1.80499014153528 2.38051469501332 1 8.76009590507743 1510 2871 4512 2712 3072 1484 1415 345 989 2406 581 1300 M11388 GO_MONOVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 164/504 Gene Ontology BP GO:0015672 1.7212036652165e-06 6.39323889408018e-06 3675 1799.18181818182 1511 1.56473182893455e-07 434 1.5735878193265 -1.46825622724046 -1 9.68265126057092 3673 1148 860 1511 1159 1457 3351 1608 1866 434 2724 1301 M16862 GO_ACUTE_PHASE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_PHASE_RESPONSE.html An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 24/111 Gene Ontology BP GO:0006953 6.01487185268617e-06 1.62839941761061e-05 2975 1639.90909090909 1511 5.46808027055018e-07 434 2.37358669483823 2.66648951619958 1 13.463530902731 2972 1178 434 475 1606 3938 2934 1675 681 635 1511 1302 M13460 GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. 36/97 Gene Ontology BP GO:0042439 5.99215929767064e-07 3.22760452025773e-06 2530 1646.27272727273 1513 5.44741902705541e-08 734 1.60156003398063 -1.57293487507856 -1 10.4179474871679 2527 1248 1541 1513 734 1700 2641 1062 1113 1361 2669 1303 M12935 GO_LEFT_RIGHT_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). 9/20 Gene Ontology BP GO:0070986 3.17491174943262e-06 9.89336594135278e-06 1420 1805.54545454545 1518 3.17491628547082e-07 118 2.22013508631275 2.68412799662636 1 13.1622965493875 1418 3292 3983 2705 2443 1518 955 118 750 1914 765 1304 M11941 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. 274/657 Gene Ontology BP GO:1902532 1.64586465058522e-07 1.61692190219132e-06 1015 1559.27272727273 1519 1.49624070337791e-08 236 1.39615815554726 1.57461211355946 1 9.57832408359345 1519 1779 2277 1594 236 1132 1406 1012 2529 2654 1014 1305 M13001 GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. 17/48 Gene Ontology BP GO:2000171 3.30248945576698e-05 6.79975988608697e-05 1900 1489.90909090909 1520 3.00230821047337e-06 659 2.15985482635685 2.41144435145366 1 10.6629868157319 1897 2552 1520 1652 2133 1780 756 776 659 1236 1428 1306 M13341 GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of chondrocyte differentiation. 22/71 Gene Ontology BP GO:0032330 2.82112490038945e-06 9.0576367324632e-06 1715 1597.27272727273 1520 2.56466228909785e-07 579 1.87779951201183 1.98653537178544 1 11.2179872874317 1713 1928 1464 867 1352 1967 1520 3155 579 1815 1210 1307 M12163 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 765/2167 Gene Ontology BP GO:0009719 2.82303688224058e-11 9.56956380061175e-10 1300 1393.36363636364 1521 2.82303688227644e-12 22 1.81282803869215 2.00398860769079 1 19.3686010737615 1296 352 3861 349 568 2129 1927 1775 1527 22 1521 1308 M15609 GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. 7/18 Gene Ontology BP GO:0051044 0.000651188182946301 0.00101153119217788 2040 1874.54545454545 1522 6.51379082403925e-05 224 1.95043586941541 -1.56398417590496 -1 6.92005430628178 2037 2175 4430 2160 2851 1068 1124 1522 224 1513 1516 1309 M10564 GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 9/17 Gene Ontology BP GO:0046130 9.36743195840701e-07 4.2103568812085e-06 1525 1566 1523 9.36743590710452e-08 326 1.27939373877687 1.51327270143228 1 8.14733792001317 1686 607 3604 1522 955 1853 1523 906 326 2669 1575 1310 M12028 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. 38/82 Gene Ontology BP GO:1904377 4.03719965842258e-07 2.61980478260637e-06 3450 2202.72727272727 1523 3.67018218116868e-08 548 1.53986838593128 -1.40002779980222 -1 10.1819401735068 3450 548 1321 710 557 3763 3027 4343 605 1523 4383 1311 M15401 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 4/13 Gene Ontology BP GO:0034374 3.07561988309317e-05 6.39503050479246e-05 1680 1782.90909090909 1523 3.07566245139184e-06 233 2.39562937601017 2.39680296933134 1 11.9026151835232 1677 1523 4397 1123 2142 1532 783 4169 233 900 1133 1312 M14254 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. 38/82 Gene Ontology BP GO:1903078 4.03719965842258e-07 2.61980478260637e-06 3455 2204.54545454545 1524 3.67018218116868e-08 549 1.53986838593128 -1.40002779980222 -1 10.1819401735068 3451 549 1322 711 558 3764 3028 4353 606 1524 4384 1313 M14324 GO_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. 212/578 Gene Ontology BP GO:0022407 2.74845701544716e-08 4.85212392498904e-07 2645 2102.09090909091 1524 2.49859731798508e-09 222 1.77181552934489 1.96427249167183 1 13.2527441275699 2643 1457 222 960 1182 4525 3615 3017 1524 226 3752 1314 M14480 GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 9/17 Gene Ontology BP GO:0006152 9.36743195840701e-07 4.2103568812085e-06 1525 1630.54545454545 1524 9.36743590710452e-08 327 1.27939373877687 1.51327270143228 1 8.14733792001317 1687 608 4243 1523 956 1854 1524 943 327 2695 1576 1315 M16959 GO_FRUCTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRUCTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. 7/26 Gene Ontology BP GO:0006000 5.52695778719903e-05 0.000106923604191521 1525 1882 1524 5.5270952546917e-06 748 1.67158935742355 -1.9829069372344 -1 7.86320222540937 1524 2041 4641 2853 2302 922 748 843 1271 2414 1143 1316 M14222 GO_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 161/453 Gene Ontology BP GO:0006066 1.02286637860318e-07 1.24978120943541e-06 2780 1647.36363636364 1525 9.29878569236599e-09 33 1.34400337148921 -1.32054070865672 -1 9.39860459109098 2778 33 1141 1939 121 1302 2811 1525 2584 1357 2530 1317 M15094 GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. 8/26 Gene Ontology BP GO:0043567 5.55882676675567e-08 8.29891725982205e-07 730 1645.09090909091 1525 5.55882690580817e-09 12 3.89925413065323 3.89925413065323 1 28.088793746777 729 2966 4351 1525 2606 1281 1748 12 140 1756 982 1318 M14311 GO_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PIGMENTATION.html The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. 22/53 Gene Ontology BP GO:0048066 6.07587913830978e-07 3.23212152206309e-06 3175 1739.27272727273 1527 5.52352801484036e-08 130 1.53552723818758 -1.31060382116581 -1 9.98730754290025 3175 130 1002 1117 740 2280 3813 1527 864 1817 2667 1319 M15027 GO_SCHWANN_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DEVELOPMENT.html The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 18/34 Gene Ontology BP GO:0014044 3.65648704544086e-06 1.10169171654652e-05 995 2136.27272727273 1527 3.32408465698286e-07 966 0.951265907049924 0.969134563934678 1 5.58703204613877 995 2350 2589 3577 1446 1527 1419 966 3719 3551 1360 1320 M13771 GO_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 15/44 Gene Ontology BP GO:0033198 0.000210299820668863 0.000358057230423737 965 1488.36363636364 1528 1.91199932812239e-05 351 1.95702806571433 2.09194648142981 1 7.98907190721337 964 1763 1826 2434 2596 564 351 1528 2065 1475 806 1321 M15965 GO_RESPONSE_TO_GONADOTROPIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GONADOTROPIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 17/37 Gene Ontology BP GO:0034698 0.000313511720436375 0.000514722389669763 1530 1729.18181818182 1530 2.85051278583825e-05 676 1.9918931033968 1.91833036231564 1 7.75947311891248 1530 1699 676 1428 2681 1597 1104 4170 2348 883 905 1322 M10096 GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION.html The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. 6/18 Gene Ontology BP GO:0002031 1.05979977106973e-05 2.60214190220875e-05 685 1295.54545454545 1531 1.05980482539365e-06 115 1.81669187736946 1.81669187736946 1 9.86659474562972 681 343 3532 1531 1796 322 115 2033 1588 2166 144 1323 M10648 GO_EMBRYONIC_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. 16/46 Gene Ontology BP GO:0000578 1.54083314060048e-06 5.97169304825377e-06 1535 1551.81818181818 1531 1.4007583816075e-07 75 1.92604984574117 -2.33445701550109 -1 11.9190221623196 1531 1703 1805 1026 2519 1517 3461 75 465 1611 1357 1324 M15041 GO_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXPLORATION_BEHAVIOR.html The specific behavior of an organism in response to a novel environment or stimulus. 14/41 Gene Ontology BP GO:0035640 7.01403574387135e-05 0.000131953678925424 1345 1657.63636363636 1531 6.37659943200458e-06 415 1.7140466373066 2.1950819509825 1 7.87744150417543 1344 3118 1744 2128 2929 1531 1083 415 869 2008 1065 1325 M16481 GO_DEVELOPMENTAL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. 114/357 Gene Ontology BP GO:0021700 5.271743676195e-06 1.46129587394468e-05 1220 1713.18181818182 1531 4.79250573512546e-07 502 1.48566953355868 1.62695454299333 1 8.50981718853431 1218 1464 502 2046 1576 1448 1531 3461 2964 873 1762 1326 M13739 GO_MAMMARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. 84/219 Gene Ontology BP GO:0030879 2.53107024238788e-06 8.44235570072336e-06 4055 1953.36363636364 1532 2.30097559486786e-07 424 1.89089018685593 -1.85614005909797 -1 11.3646253182968 4054 1532 445 455 1303 2391 3579 2813 983 424 3508 1327 M10345 GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. 26/73 Gene Ontology BP GO:0046470 4.6291739043434e-06 1.31860456674027e-05 1535 2116.27272727273 1533 4.20834876812795e-07 528 1.90215888908287 -1.91065160145406 -1 10.9959929224344 3984 2017 1533 1423 1533 2750 3318 1305 528 959 3929 1328 M11794 GO_COPPER_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_TRANSPORT.html The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/20 Gene Ontology BP GO:0006825 6.13984747460618e-07 3.23212152206309e-06 1795 1529.81818181818 1533 5.58168108012718e-08 597 1.26176477942203 -0.991630062411121 -1 8.20671371050752 1794 597 2066 1717 751 1009 1392 2990 1400 1533 1579 1329 M12642 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. 69/180 Gene Ontology BP GO:1903169 1.5093080820937e-07 1.53712129220667e-06 1230 1473.81818181818 1534 1.37209835058151e-08 213 1.62911613101256 1.91598445544283 1 11.2189498883138 1534 2089 1091 1331 213 1674 1229 1713 2520 1591 1227 1330 M13483 GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. 204/405 Gene Ontology BP GO:0007264 3.18712130840767e-07 2.31940505249793e-06 2725 1993.36363636364 1534 2.89738342738484e-08 456 1.55378082903642 1.68004720352021 1 10.3712877660748 2725 1307 912 1072 456 4330 2683 2259 1534 700 3949 1331 M14093 GO_VENTRICULAR_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_DEVELOPMENT.html The progression of the ventricular septum over time from its formation to the mature structure. 40/78 Gene Ontology BP GO:0003281 2.27115462367662e-06 7.81108956868928e-06 1175 1701.09090909091 1534 2.06468815299146e-07 791 1.33972052322321 1.32411631579208 1 8.1055521227671 1171 791 1705 2099 1258 1546 1534 3132 3188 824 1464 1332 M12120 GO_RESPONSE_TO_XENOBIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_XENOBIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. 42/205 Gene Ontology BP GO:0009410 4.4807747207058e-05 8.90211254952377e-05 1340 1801.27272727273 1535 4.07351453086727e-06 923 1.6567253774992 -1.27666354396325 -1 7.9494652080919 1338 979 923 1865 2215 1144 1611 4504 1535 1455 2245 1333 M12168 GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. 11/24 Gene Ontology BP GO:0051446 1.83057558452887e-05 4.13997196247811e-05 2685 1687.27272727273 1535 1.66417346959653e-06 451 2.19840622524088 -1.89072712184083 -1 11.4145215178621 2683 708 1454 510 1939 2667 2854 1162 451 1535 2597 1334 M16403 GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. 12/29 Gene Ontology BP GO:0048384 1.94920208762949e-05 4.35312423899168e-05 3580 1938.72727272727 1540 1.77201759799337e-06 612 2.07089075610248 -2.75118635302525 -1 10.6989490802578 3577 1110 1540 1165 1960 2684 1961 1009 612 1118 4590 1335 M10744 GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 10/29 Gene Ontology BP GO:0072207 4.79042050552143e-06 1.35621478092293e-05 4115 2100.45454545455 1541 4.35493721501889e-07 159 1.77689859168176 1.47010230688903 1 10.2461789749119 4114 323 738 362 1541 4595 3554 2663 159 605 4451 1336 M12097 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 12/35 Gene Ontology BP GO:0050650 7.16684670544887e-05 0.00013450149253597 280 1403.09090909091 1541 6.51552744311209e-06 219 1.85606970191585 1.85606970191585 1 8.51189160211588 278 2031 1108 2186 2349 510 219 1541 2695 1649 868 1337 M12377 GO_POSITIVE_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_RATE.html Any process that activates or increases the frequency or rate of heart contraction. 13/35 Gene Ontology BP GO:0010460 2.9778486715728e-05 6.21959126500788e-05 765 1323.54545454545 1541 2.70717179957343e-06 580 2.38607845754666 2.77531032004405 1 11.8893091144444 894 1807 762 1722 2095 991 762 1564 1541 1841 580 1338 M12855 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. 3/14 Gene Ontology BP GO:0046929 0.000112030662040131 0.000200988548629183 1210 1708.72727272727 1542 1.12036310332053e-05 158 1.39040237939933 -1.39040237939933 -1 6.08902573386393 1210 1828 3969 1542 2479 892 609 2709 158 2584 816 1339 M15685 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 39/149 Gene Ontology BP GO:0021954 1.2965243906561e-05 3.08389484929112e-05 1830 1691.36363636364 1543 1.17866548319713e-06 709 1.91812391575319 1.96118251623885 1 10.2498599742757 1436 2585 709 1028 1830 2067 1543 3300 1496 784 1827 1340 M15931 GO_MELANOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. 11/30 Gene Ontology BP GO:0030318 5.01427685349235e-07 2.89556769973244e-06 2640 1355.54545454545 1545 4.55843454214099e-08 489 1.99616739225785 2.20646508495074 1 13.0963066481005 2636 705 753 489 656 2335 1684 1581 592 1545 1935 1341 M10081 GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION.html The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. 22/66 Gene Ontology BP GO:0060395 1.90562710751696e-05 4.27431239623248e-05 1655 1417.54545454545 1546 1.7324032855886e-06 225 2.17432844211375 2.25928904116145 1 11.2537826288632 1655 1975 1284 708 1951 2032 1214 1546 225 1321 1682 1342 M14060 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. 2/15 Gene Ontology BP GO:0044794 0.000368713991676717 0.000596286681767676 1655 1767.7 1547 4.09749364370329e-05 83 3.10979094994676 3.10979094994676 1 11.8789392931446 1653 2532 4178 NA 2773 1318 1441 671 83 2294 734 1343 M11501 GO_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of the process of creating protein polymers. 92/225 Gene Ontology BP GO:0032271 7.27030895090957e-07 3.56829222611767e-06 1585 1512 1548 6.60937395774492e-08 229 1.63597805020278 1.72967455534052 1 10.5573738275288 1581 642 1548 229 823 2508 1506 2514 1077 2044 2160 1344 M14739 GO_HINDBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_MORPHOGENESIS.html The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. 33/80 Gene Ontology BP GO:0021575 6.10552282050717e-07 3.23212152206309e-06 1160 2167.90909090909 1548 5.55047683175955e-08 285 1.74920084512186 -1.54031117671865 -1 11.3770740885687 3564 1548 1159 285 743 4293 3764 2174 1396 1160 3761 1345 M15035 GO_NEUROTRANSMITTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 9/41 Gene Ontology BP GO:0042133 3.58584176385136e-07 2.49410561464439e-06 1880 1709.45454545455 1548 3.58584234247323e-08 545 2.58672042449194 -1.71202983846214 -1 17.1693864004666 1876 1211 4336 599 545 2024 721 1548 1507 1920 2517 1346 M14126 GO_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_METABOLIC_PROCESS.html The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 102/392 Gene Ontology BP GO:0008202 3.57445628626423e-07 2.49281718252034e-06 4205 1929.90909090909 1549 3.24950624275015e-08 389 1.64015618489231 -1.55069959091754 -1 10.8869908395014 4201 389 563 675 491 1883 3904 2836 1549 677 4061 1347 M12429 GO_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 58/151 Gene Ontology BP GO:0009308 4.9138404353923e-07 2.88067691180889e-06 4020 2090.36363636364 1551 4.46712866630024e-08 258 1.81510868957819 -1.65199596294975 -1 11.913244705017 4019 258 576 1112 643 2827 4461 2834 1551 869 3844 1348 M12857 GO_POSITIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_GROWTH.html Any process that activates or increases the frequency, rate, extent or direction of cell growth. 103/233 Gene Ontology BP GO:0030307 1.43019647968363e-06 5.6804125365022e-06 1415 1563.45454545455 1551 1.30017946312719e-07 866 1.78259114308774 2.08176844190005 1 11.0771137830248 1413 2851 866 2080 1077 1670 1812 1240 1687 951 1551 1349 M10302 GO_MAMMARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_MORPHOGENESIS.html The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 40/77 Gene Ontology BP GO:0060443 4.88223713822494e-06 1.37549921315403e-05 3900 2134.90909090909 1553 4.43840724810264e-07 280 1.8739985939871 -1.83220598763624 -1 10.7924768851498 3899 980 764 280 1553 3204 4621 4057 468 422 3236 1350 M14851 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell migration. 78/152 Gene Ontology BP GO:0010634 7.75964715755574e-07 3.70658865766783e-06 1555 1514.81818181818 1555 7.05422717679256e-08 300 1.71534046756924 1.61209151385036 1 11.0359625848271 1555 397 300 367 1430 2295 1885 3482 1663 401 2888 1351 M16579 GO_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that modulates the frequency, rate or extent of lymphocyte migration. 21/59 Gene Ontology BP GO:2000401 3.46188116633645e-05 7.08084328427318e-05 1515 1584.45454545455 1556 3.14721422098867e-06 547 1.93768130552756 2.14010624592972 1 9.52575873198619 1512 1556 713 547 2147 2615 2197 1144 1887 909 2202 1352 M10047 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. 4/18 Gene Ontology BP GO:0036150 1.10973198500817e-05 2.69754282232106e-05 1395 1940.27272727273 1557 1.10973752681997e-06 92 3.17112867683882 -3.17112867683882 -1 17.1639045535675 1392 3268 3523 2126 3607 1461 1557 217 92 2768 1332 1353 M14817 GO_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 141/332 Gene Ontology BP GO:0051260 2.46991703229573e-07 2.00203502611962e-06 3855 2185.18181818182 1557 2.24537937235525e-08 38 1.67257038817929 1.74406601948502 1 11.2908113765383 3851 38 856 1557 376 2753 4438 4004 1326 567 4271 1354 M10696 GO_SALIVARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SALIVARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. 18/55 Gene Ontology BP GO:0007431 8.71854845660783e-07 4.0079426221812e-06 1680 1481.27272727273 1561 7.92595628340916e-08 398 1.93452918257389 -1.32204535880585 -1 12.3683584557673 1676 1561 1056 398 894 2600 1828 1358 613 2438 1872 1355 M10732 GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS.html The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. 13/43 Gene Ontology BP GO:0060441 1.59747469493318e-06 6.08798146965442e-06 1435 1899.72727272727 1561 1.45225077718223e-07 1121 2.11886919152268 2.04728049368006 1 13.091227298802 1433 2067 1422 1911 1121 2036 1296 3505 1561 3164 1381 1356 M14271 GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION.html The modification of a protein by cis-trans isomerization of a proline residue. 15/41 Gene Ontology BP GO:0000413 6.47270075342992e-06 1.7271695171365e-05 1800 1450.63636363636 1561 5.88429072461712e-07 454 1.76268054906159 1.96755036723245 1 9.94492880661514 1797 464 1561 674 1635 3272 2815 936 454 711 1638 1357 M11381 GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 12/20 Gene Ontology BP GO:0090335 5.01775694618801e-06 1.40515352841682e-05 925 1581.18181818182 1562 4.56160762792512e-07 222 2.70612816621795 2.70612816621795 1 15.5550686421905 925 2359 2283 2307 1562 681 222 1428 1718 3042 866 1358 M12076 GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 14/34 Gene Ontology BP GO:0072529 0.00316025782434724 0.00443563394148859 1450 1970 1562 0.000287709693157303 934 2.19335900903036 2.78072159027378 1 6.11389265010924 1447 3605 1772 2801 3163 1562 1220 1075 1470 2621 934 1359 M14213 GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 54/160 Gene Ontology BP GO:0042035 8.22144350197989e-07 3.83930494928787e-06 2215 1689.36363636364 1563 7.47404234031927e-08 595 1.38390250777628 -1.53749146292747 -1 8.87854734478147 2211 1078 1584 1328 873 1641 4554 595 1838 1318 1563 1360 M13092 GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION.html Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. 21/62 Gene Ontology BP GO:0002026 4.78893318422145e-06 1.35621478092293e-05 1435 1572.54545454545 1565 4.35358509885873e-07 1098 1.72973137388688 2.16133910995279 1 9.97419731154628 1435 1098 1249 1664 1540 1565 1604 1341 1835 1684 2283 1361 M13026 GO_RESPONSE_TO_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 482/1432 Gene Ontology BP GO:0009725 5.09454157606866e-21 1.07517984262213e-18 1570 1270.36363636364 1566 4.63140143278969e-22 21 1.79387924379926 1.89195387871374 1 38.1841887238506 1570 200 21 43 670 2786 2208 2987 1566 37 1886 1362 M15378 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. 14/41 Gene Ontology BP GO:0071526 7.19226023067489e-05 0.000134923895963731 685 1575.81818181818 1566 6.53863215588177e-06 463 1.80487471614915 2.1216424358978 1 8.27420098594068 683 1417 463 1159 3207 1856 1566 1959 2475 935 1614 1363 M15365 GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS.html Any apoptotic process that contributes to the shaping of an anatomical structure. 15/28 Gene Ontology BP GO:0060561 0.000259436731994604 0.000432053352457298 1135 1749.72727272727 1567 2.35879392115838e-05 501 1.48704747444631 1.79926389128229 1 5.92677608489239 1132 1906 1923 1705 4233 1482 1565 1111 1567 2122 501 1364 M12683 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin receptor signaling. 10/20 Gene Ontology BP GO:0046628 0.00010968279204351 0.00019692853962027 1330 1722.90909090909 1568 9.97166006819644e-06 1205 1.6273332817831 1.50958447664844 1 7.14370889116738 1326 1205 2017 1708 2459 1568 1209 2446 1484 2064 1466 1365 M14312 GO_ARGININE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARGININE_METABOLIC_PROCESS.html The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. 9/21 Gene Ontology BP GO:0006525 2.98864840429248e-06 9.47187340691467e-06 3080 1984.27272727273 1568 2.98865242370877e-07 155 2.49713540229363 2.12020078450785 1 14.8604545486452 3077 712 4222 155 1405 2785 1568 3391 481 1206 2825 1366 M13485 GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. 190/457 Gene Ontology BP GO:0071902 2.27846412474859e-06 7.82463678343764e-06 1535 1666.18181818182 1569 2.07133316770793e-07 477 1.66263831298268 1.81747111613304 1 10.0577814643364 1533 1831 602 1015 1260 3119 2970 2274 1569 477 1678 1367 M13580 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. 79/186 Gene Ontology BP GO:2000379 2.87163167259121e-06 9.17617746444666e-06 1470 1662.63636363636 1569 2.61057765536537e-07 948 1.62879227272051 1.6404451276365 1 9.71952041348505 1469 2747 1104 1346 1359 2044 1569 1585 1800 948 2318 1368 M10588 GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. 20/54 Gene Ontology BP GO:0030517 0.00681734015534643 0.00923633216844863 1150 1733.81818181818 1570 0.000621687070302517 686 1.55756849268944 1.7138509143413 1 3.75390132238018 1147 686 829 1272 3255 2284 1593 2021 2886 1570 1529 1369 M10571 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. 11/23 Gene Ontology BP GO:1901017 2.93791898452724e-06 9.33658990086242e-06 1790 1567.45454545455 1571 2.67083900716696e-07 916 1.55268093278657 1.79128947490872 1 9.25149611409601 1789 1112 1954 916 1368 1980 1571 2383 1251 982 1936 1370 M10985 GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. 12/23 Gene Ontology BP GO:2000050 0.0065359633345162 0.00887064535579033 1480 1758.36363636364 1571 0.00059595110247016 877 1.47296381194651 1.4573003284224 1 3.58060826091298 1476 1571 2082 1219 3247 1802 959 3309 877 1108 1692 1371 M12496 GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. 26/74 Gene Ontology BP GO:1903307 2.4624720404911e-07 2.00203502611962e-06 915 2254.18181818182 1572 2.23861119646999e-08 125 1.48255966124433 1.65154796591096 1 10.0081295760884 3953 125 1572 915 373 4192 3786 3717 914 962 4287 1372 M10730 GO_NADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. 12/41 Gene Ontology BP GO:0006739 0.000195318099523503 0.000334265365310587 830 1769.81818181818 1575 1.77577674733086e-05 586 1.05565536113561 -1.00886245832362 -1 4.34678782332638 827 1575 2406 2745 2580 631 586 1145 2953 3039 981 1373 M15414 GO_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_INVAGINATION.html The infolding of a membrane, resulting in formation of a vesicle. 26/170 Gene Ontology BP GO:0010324 3.96060525826272e-06 1.16848191249719e-05 2865 1901.72727272727 1576 3.60055671678162e-07 127 1.95541364915887 -1.51928100284306 -1 11.4254425934665 2863 127 1388 1576 1479 2495 3032 2828 647 965 3519 1374 M14038 GO_RESPONSE_TO_NICOTINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NICOTINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. 28/72 Gene Ontology BP GO:0035094 4.56502396038686e-06 1.3043326921893e-05 2860 2092.09090909091 1580 4.15003039353529e-07 457 1.99007550170217 2.24194110248222 1 11.5153629251722 2858 912 650 457 1528 4099 3266 3380 1580 1102 3181 1375 M14689 GO_DENDRITIC_SPINE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. 15/39 Gene Ontology BP GO:0097061 1.83053980437293e-07 1.73047531437208e-06 1795 1345.18181818182 1580 1.66412723335045e-08 123 1.72317292488567 1.95670938863418 1 11.7616347450946 1793 1638 1716 123 267 1818 952 3048 386 1476 1580 1376 M14326 GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS.html The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. 6/16 Gene Ontology BP GO:0060670 5.71473438024367e-06 1.56171346247624e-05 1905 1790.27272727273 1581 5.71474907648193e-07 641 1.36888305064514 0.882116170792044 1 7.79406714253077 1905 725 4224 1581 1625 1287 641 1441 1148 3147 1969 1377 M10984 GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 67/163 Gene Ontology BP GO:0007249 2.09614976199561e-06 7.38984308651907e-06 1405 2148 1582 1.90559250836365e-07 570 1.08437363701178 -1.23879303972963 -1 6.59158460464532 1401 2748 3196 3278 1228 570 1486 1582 3245 3855 1039 1378 M11327 GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. 84/198 Gene Ontology BP GO:0098780 3.64217000190526e-08 5.99281766227978e-07 780 2326.45454545455 1583 3.31106369291139e-09 22 2.05385977207596 -1.52006064476569 -1 15.1392583338381 3845 1154 776 1562 22 3527 4117 4583 776 1583 3646 1379 M11738 GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. 98/242 Gene Ontology BP GO:0043409 1.86861280296956e-07 1.73572332354834e-06 1475 1537.90909090909 1583 1.69873905607622e-08 282 1.53788120611326 1.8370794796001 1 10.4945174213911 1474 2248 2039 1928 282 1166 910 748 1776 2763 1583 1380 M15367 GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. 13/33 Gene Ontology BP GO:0006658 2.55234899237765e-05 5.48890985252868e-05 690 1574.36363636364 1583 2.32034418559617e-06 583 1.71141801760444 -1.71141801760444 -1 8.63765997180446 689 2988 1983 2493 2029 583 662 964 1583 2485 859 1381 M13888 GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION.html The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential. 84/198 Gene Ontology BP GO:0098779 3.64217000190526e-08 5.99281766227978e-07 780 2327.45454545455 1584 3.31106369291139e-09 23 2.05385977207596 -1.52006064476569 -1 15.1392583338381 3846 1155 777 1563 23 3528 4118 4584 777 1584 3647 1382 M15925 GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. 12/30 Gene Ontology BP GO:1902170 0.0192336796522272 0.0247511016145485 3745 2408.81818181818 1584 0.00176399263745911 1188 1.79490173784953 2.28760519432657 1 3.41565296483668 1446 3744 1188 3222 3958 1584 1559 1480 3741 3060 1515 1383 M12513 GO_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 4/33 Gene Ontology BP GO:0042417 0.000312086976055192 0.000512564495869918 1345 1998.54545454545 1585 3.12130813946503e-05 556 3.06908479856712 3.06908479856712 1 11.962336689992 1342 3565 3921 2442 2698 1347 556 670 1075 2783 1585 1384 M15648 GO_MACROMITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMITOPHAGY.html Degradation of a mitochondrion by macroautophagy. 84/198 Gene Ontology BP GO:0000423 3.64217000190526e-08 5.99281766227978e-07 780 2327.81818181818 1586 3.31106369291139e-09 24 2.05385977207596 -1.52006064476569 -1 15.1392583338381 3847 1156 778 1564 24 3529 4119 4577 778 1586 3648 1385 M14347 GO_REGULATION_OF_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. 44/107 Gene Ontology BP GO:0006885 2.79167853113441e-05 5.91051683541135e-05 1185 1661.09090909091 1587 2.53792177874813e-06 837 1.66736997072522 -1.51241443253193 -1 8.35186448790214 1181 2256 1331 2234 2066 837 2088 1383 1871 1587 1438 1386 M10304 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. 13/25 Gene Ontology BP GO:1900015 7.4357042920716e-07 3.61865792670656e-06 2645 1812.36363636364 1591 6.7597334593099e-08 835 2.12927014491316 2.69601914313493 1 13.7253571205777 2644 1013 1200 958 835 3185 2377 2555 1591 1242 2336 1387 M13808 GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. 40/130 Gene Ontology BP GO:0017158 4.59543356913616e-06 1.31097913988894e-05 1555 1828.09090909091 1591 4.17767560750868e-07 983 1.42382705723911 1.47882294139262 1 8.23510207814382 1553 983 1591 2488 1530 1951 1413 3028 2768 1028 1776 1388 M14085 GO_RESPONSE_TO_AMINO_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINO_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 78/177 Gene Ontology BP GO:0043200 5.55739352121062e-06 1.52499870679556e-05 4030 2201.36363636364 1592 5.05218869065924e-07 483 2.08893244326099 -1.98974778125534 -1 11.9194107328603 4028 886 483 845 1592 3194 3355 3420 1184 763 4465 1389 M13178 GO_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that modulates the frequency, rate or extent of response to wounding. 236/603 Gene Ontology BP GO:1903034 7.52710867867946e-11 2.29923457862557e-09 1595 1620.81818181818 1594 6.8428260717609e-12 140 1.75151501046516 1.87291252287173 1 17.9236343317264 1594 631 140 747 375 3380 2684 3327 1948 191 2812 1390 M15469 GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of skeletal muscle contraction. 11/25 Gene Ontology BP GO:0014819 7.90116899859007e-05 0.000146623212072157 1020 1703.72727272727 1594 7.1831388896713e-06 640 2.01694336599879 2.01694336599879 1 9.16011380936881 1018 2637 1594 2800 2378 1076 750 640 1833 2943 1072 1391 M11573 GO_OVULATION_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE.html The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 61/155 Gene Ontology BP GO:0042698 2.4929882560286e-06 8.33329335690481e-06 2140 1775.81818181818 1595 2.26635552820794e-07 772 1.74120390727629 1.76161891003236 1 10.4766287291359 2136 772 909 837 1299 3133 2110 3862 1595 801 2080 1392 M16953 GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 134/317 Gene Ontology BP GO:0000302 6.55453732255568e-06 1.7419986713581e-05 1585 1840.36363636364 1595 5.95868804618232e-07 552 1.7009808211116 2.0481026637836 1 9.58934145766688 1583 1065 552 1595 1644 3494 3337 992 2432 1157 2393 1393 M11644 GO_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 180/425 Gene Ontology BP GO:0002521 5.27451843332432e-07 2.97564873462027e-06 1455 1658.18181818182 1599 4.79501790717724e-08 608 1.61640353066297 1.86564087711628 1 10.5820931453845 1452 2422 608 981 684 3403 2541 1994 1599 817 1739 1394 M14390 GO_CELL_FATE_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_DETERMINATION.html A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. 22/63 Gene Ontology BP GO:0001709 4.82173073274211e-05 9.51032106717147e-05 1245 1705.90909090909 1601 4.38348764877652e-06 685 2.07292816924346 2.44097311452796 1 9.87604980345875 1243 685 745 932 2233 2746 3102 1601 1984 1326 2168 1395 M15689 GO_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTOSIS.html A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells. 174/474 Gene Ontology BP GO:0006887 9.05283702874439e-07 4.12891181969157e-06 1200 1804.36363636364 1601 8.2298552308381e-08 660 1.59045505883011 1.68569394886348 1 10.144198598416 1199 1601 660 2486 906 2002 1295 3121 2746 902 2930 1396 M10794 GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. 22/44 Gene Ontology BP GO:0051145 0.000143119776091909 0.00025066205974905 1015 1681.81818181818 1602 1.30117352288529e-05 808 1.85921076031623 1.79835389359121 1 7.93083782172169 1015 1796 808 1762 2515 1115 934 1602 3656 1322 1975 1397 M12656 GO_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 375/1075 Gene Ontology BP GO:0051046 2.7824614575871e-10 7.82967790762238e-09 1605 1414.54545454545 1602 2.52951041630819e-11 153 1.65973103732539 1.82189056906146 1 15.9380832778183 1602 739 153 639 997 2590 2096 2595 2059 161 1929 1398 M16835 GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that modulates the frequency, rate or extent of execution phase of apoptosis. 19/35 Gene Ontology BP GO:1900117 5.89934763534943e-06 1.60366926644774e-05 2110 1633 1602 5.36305768603385e-07 642 2.09998791538573 2.35703853812391 1 11.9281488252185 2107 1339 1397 2288 1602 2340 1377 642 1173 2031 1667 1399 M15541 GO_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_STORAGE.html The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 18/37 Gene Ontology BP GO:0019915 7.41462384682605e-07 3.61618681941317e-06 1970 1615.36363636364 1604 6.74056940524156e-08 453 1.40152069363766 -1.40105617360671 -1 9.03474819097568 1970 453 1434 1604 833 1589 2657 2388 1777 1347 1717 1400 M16446 GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT.html The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. 24/58 Gene Ontology BP GO:0031076 6.02136324919233e-06 1.6292068511655e-05 3605 2014.36363636364 1607 5.47398157238738e-07 417 1.75305841869082 -1.64411951641866 -1 9.94330394175591 3603 680 1250 1442 1607 2561 3951 1687 417 1488 3472 1401 M13098 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. 7/17 Gene Ontology BP GO:2000778 0.000256689275951546 0.000428092064742468 1905 1937.63636363636 1608 2.56718930995652e-05 977 1.73234847219934 2.0093317552879 1 6.91265705892284 1903 1664 4011 1543 2664 2709 1608 1235 977 1499 1501 1402 M11759 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 23/38 Gene Ontology BP GO:1903846 6.05513921049147e-06 1.63643837917997e-05 3950 2515.27272727273 1609 5.50468716030304e-07 710 2.13661569001578 -1.97382416219167 -1 12.113963318409 3946 1405 710 997 1609 4349 4251 4222 911 781 4487 1403 M11902 GO_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/164 Gene Ontology BP GO:0002028 2.2675498739828e-07 1.93890130108695e-06 3525 2055.81818181818 1610 2.06140918881838e-08 339 1.72176584755532 -1.82639138976583 -1 11.6512925308827 3521 778 826 764 339 4341 3054 2100 1610 798 4483 1404 M13331 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. 23/38 Gene Ontology BP GO:0030511 6.05513921049147e-06 1.63643837917997e-05 3950 2514.90909090909 1610 5.50468716030304e-07 711 2.13661569001578 -1.97382416219167 -1 12.113963318409 3947 1406 711 998 1610 4350 4252 4207 912 783 4488 1405 M15242 GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. 13/29 Gene Ontology BP GO:2000178 0.000151874922274135 0.000264499348881774 1610 1868 1610 1.38077643481254e-05 622 1.55438571981448 1.56064171107166 1 6.58757515961228 1610 703 2246 622 2531 1173 1167 2498 3920 2484 1594 1406 M14517 GO_CELLULAR_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 39/108 Gene Ontology BP GO:0071277 1.8772913214907e-07 1.73637310632855e-06 1615 1541.27272727273 1612 1.70662861971151e-08 284 1.72852252276956 -1.75756664509734 -1 11.7951231205219 1612 1322 771 1689 284 1599 2340 1681 2544 1265 1847 1407 M10998 GO_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. 75/161 Gene Ontology BP GO:0002573 5.34418482950353e-06 1.47960943132886e-05 1580 2011 1613 4.85836164682495e-07 1146 1.55957325025736 1.71377765976602 1 8.92313990102201 1146 4181 1725 2794 1578 1613 1211 1382 2403 2511 1577 1408 M11349 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. 16/41 Gene Ontology BP GO:0030835 2.67386180297115e-06 8.71743070470187e-06 3630 2112.09090909091 1614 2.43078641160563e-07 358 1.70102505967131 1.44743538236038 1 10.1954385743166 3626 692 1191 1160 1331 3391 2888 2390 358 1614 4592 1409 M16945 GO_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. 23/58 Gene Ontology BP GO:0019933 7.75528881283247e-05 0.00014455160962658 350 1413.18181818182 1614 7.0505111003972e-06 83 1.75188172004042 1.75188172004042 1 7.96913936431581 346 2020 1614 2259 2825 278 83 442 2923 2427 328 1410 M10666 GO_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COAGULATION.html Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. 48/144 Gene Ontology BP GO:0050818 5.21004807484204e-09 1.14756934295211e-07 650 1526.18181818182 1615 4.73640735198226e-10 191 1.92330193252341 1.88024555676989 1 15.8124376999319 646 1615 191 1561 2309 1773 1542 2558 2425 360 1808 1411 M12014 GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. 14/25 Gene Ontology BP GO:0046621 6.14668085239194e-06 1.65635746939383e-05 2245 1644.72727272727 1615 5.58790729632048e-07 133 3.0178208416657 3.41504248625407 1 17.091345777623 2241 2597 1385 181 1615 3124 1408 1337 133 2001 2070 1412 M12711 GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized during embryonic development. 16/43 Gene Ontology BP GO:0048596 2.52938106992913e-05 5.44456017973155e-05 2575 1626.18181818182 1617 2.29946377378506e-06 149 1.85602126216483 -1.46589228980303 -1 9.37523052910982 2572 308 1224 1133 2027 1600 2133 2275 149 1617 2850 1413 M11274 GO_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORT.html The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 60/215 Gene Ontology BP GO:0006836 2.44523564790546e-06 8.19994660148226e-06 1660 1487.63636363636 1618 2.22294396883417e-07 637 1.48174998480986 1.67583903441785 1 8.92782036921611 1659 1679 1210 1047 1293 1618 1507 1907 2012 637 1795 1414 M13193 GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. 16/30 Gene Ontology BP GO:0036119 6.56686506222351e-05 0.000124510835070255 960 1567.27272727273 1618 5.9700555339178e-06 409 1.7839177772354 2.15342205392495 1 8.25184090892628 956 1803 1139 1618 2428 1442 929 409 2242 2259 2015 1415 M11330 GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. 10/25 Gene Ontology BP GO:1902931 6.17227350299271e-06 1.66132555793595e-05 3930 1928.72727272727 1619 5.61117347260074e-07 45 2.85909731492533 -1.82535083347038 -1 16.1880140314402 3926 934 1146 633 1619 2499 3776 872 45 2058 3708 1416 M14644 GO_PEPTIDYL_TYROSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_MODIFICATION.html The modification of peptidyl-tyrosine. 90/243 Gene Ontology BP GO:0018212 1.19714597282476e-07 1.35569481751838e-06 1620 1493 1619 1.08831457997121e-08 148 1.73320741062694 1.85347909728987 1 12.0477708425694 1619 1677 715 809 148 2649 2380 1945 1467 1173 1841 1417 M15213 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that activates or increases the rate or extent of osteoblast proliferation. 12/22 Gene Ontology BP GO:0033690 4.43666433737735e-06 1.2723553130601e-05 1535 1767.54545454545 1619 4.0333393497009e-07 1364 1.73675355024995 1.4882842170736 1 10.0717204287352 1364 2671 1810 1977 1522 1512 1533 1619 2240 1661 1534 1418 M13476 GO_DETOXIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETOXIFICATION.html Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. 35/97 Gene Ontology BP GO:0098754 1.34818308159016e-06 5.44314265028097e-06 1465 1845.72727272727 1621 1.22562173433782e-07 947 1.54609895818317 -1.48037966068523 -1 9.64147751336677 1461 1621 1229 2426 1057 947 1445 2995 3077 2099 1946 1419 M13972 GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 10/26 Gene Ontology BP GO:0045073 4.59261815668519e-05 9.09318810298052e-05 2125 1730.36363636364 1621 4.17519457532532e-06 1157 1.79692054178832 -1.8363934641712 -1 8.60253093033155 2122 2166 1565 1345 2221 1271 2311 1157 1882 1373 1621 1420 M15263 GO_OLIGODENDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DEVELOPMENT.html The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. 16/53 Gene Ontology BP GO:0014003 1.32662904362742e-07 1.42738586335742e-06 3250 1846.18181818182 1621 1.20602647602265e-08 59 2.55570684389021 -1.94862262797604 -1 17.6973274246638 4240 460 1257 370 178 3246 2750 2879 59 1621 3248 1421 M16080 GO_NEURONAL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ACTION_POTENTIAL.html An action potential that occurs in a neuron. 8/51 Gene Ontology BP GO:0019228 4.33498683958779e-06 1.25537855639129e-05 1005 1609.63636363636 1624 4.3349952960609e-07 111 3.8250398715227 3.8250398715227 1 22.2084731467922 1002 2821 4504 1393 1660 1624 1718 146 111 1761 966 1422 M12157 GO_STARTLE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STARTLE_RESPONSE.html An action or movement due to the application of a sudden unexpected stimulus. 6/45 Gene Ontology BP GO:0001964 4.87120754655436e-07 2.86654203278225e-06 2825 1972.27272727273 1625 4.87120861434452e-08 364 2.4696076022918 -0.701184282158677 -1 16.215218819921 2821 1300 3859 1022 694 2755 2616 1625 364 3121 1518 1423 M14748 GO_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY.html The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. 22/45 Gene Ontology BP GO:0014896 0.00222152863283513 0.00317762090026294 920 2060.27272727273 1627 0.000202161370655917 917 1.59914455432957 1.74056083006762 1 4.73195228329269 917 2696 1627 3311 3205 1177 1421 980 3679 2307 1343 1424 M15703 GO_ZINC_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. 7/27 Gene Ontology BP GO:0055069 0.000566801148680095 0.000892692582537884 1630 2009.63636363636 1627 5.66945769191771e-05 741 1.68546722220518 1.68546722220518 1 6.08832983394828 1627 1872 4443 2158 3618 1471 862 741 1449 2402 1463 1425 M16186 GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycosyl compound. 22/46 Gene Ontology BP GO:1901658 9.11917748259667e-07 4.14694819311423e-06 1290 1526.54545454545 1627 8.29016478415592e-08 909 1.33762227110434 1.71415775607114 1 8.52858730315201 1290 1632 1817 1946 909 1672 1004 1103 1627 2310 1482 1426 M16329 GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 191/682 Gene Ontology BP GO:0098660 4.00294763016038e-07 2.61980478260637e-06 2280 1825.81818181818 1628 3.63904396227778e-08 150 1.67646478955154 1.72253088452554 1 11.0851450525754 2279 633 317 987 550 4008 3019 4103 1628 150 2410 1427 M12188 GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 9/21 Gene Ontology BP GO:0010893 7.30737367837993e-06 1.90539661742963e-05 1325 1760.72727272727 1629 7.30739770746067e-07 183 2.06477336443483 -2.81254179094191 -1 11.5449955672986 1321 2239 3866 1737 3258 751 1283 183 1629 2679 422 1428 M13401 GO_EXOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCRINE_SYSTEM_DEVELOPMENT.html Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. 26/75 Gene Ontology BP GO:0035272 3.57377359257182e-07 2.49281718252034e-06 2785 1823.27272727273 1629 3.24888561191903e-08 490 1.7800921956777 -1.31984432898357 -1 11.8158550031128 2782 1327 1178 1096 490 3646 2181 1629 944 2208 2575 1429 M11803 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE.html Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. 30/118 Gene Ontology BP GO:0050885 1.6453657629221e-06 6.21597496928177e-06 2435 1728.90909090909 1630 1.49578817589254e-07 548 1.85871408185158 -1.42949229478031 -1 11.4639881307202 2433 798 690 548 1135 2405 2399 3117 1062 1630 2801 1430 M15312 GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 17/34 Gene Ontology BP GO:0090181 1.98661446602893e-05 4.4133258209437e-05 1200 1541.90909090909 1630 1.80602945955908e-06 405 1.45964455886941 -1.20639844432654 -1 7.53072193890769 1200 1344 2068 1630 1970 405 693 1733 2474 2910 534 1431 M11579 GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of activated T cell proliferation. 20/43 Gene Ontology BP GO:0046006 6.44095031822882e-06 1.72166564925368e-05 4580 2077.27272727273 1632 5.85542652318779e-07 298 1.81227596430702 -1.49491746135521 -1 10.2277188164467 4579 298 725 1270 1632 3136 2309 3315 926 827 3833 1432 M13820 GO_RESPONSE_TO_CAFFEINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAFFEINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. 10/34 Gene Ontology BP GO:0031000 0.000590967671706289 0.000928235081100237 1635 1723.45454545455 1632 5.37387707412879e-05 565 1.38814192259525 1.38814192259525 1 4.98643325149705 804 1911 1137 1632 3177 797 565 1634 3840 2827 634 1433 M16837 GO_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 76/200 Gene Ontology BP GO:0051592 1.90496595148191e-08 3.62490037406988e-07 3460 1932.18181818182 1632 1.73178724361535e-09 4 1.65349030146 -1.58654058248747 -1 12.6157487462849 3458 69 486 304 4 4460 3633 2629 1632 371 4208 1434 M10809 GO_NEURON_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. 21/65 Gene Ontology BP GO:0042551 8.42673932339323e-08 1.10836687474546e-06 2180 1842.27272727273 1633 7.66067240560518e-09 85 2.01709016420902 2.17096584718275 1 14.2301083413423 2177 1633 838 1401 85 2733 2537 3476 1571 906 2908 1435 M14037 GO_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 491/1440 Gene Ontology BP GO:0033993 2.32152511228034e-25 1.07788410963176e-22 1635 1396.81818181818 1633 2.11047737480029e-26 10 1.84144958601734 1.98488512077246 1 47.9200354008814 1633 498 10 291 479 3291 2615 2384 1774 36 2354 1436 M15106 GO_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 57/138 Gene Ontology BP GO:0010827 8.92936529429913e-06 2.2471026049556e-05 1510 1681.36363636364 1635 8.11763776094038e-07 1123 1.65266735126331 1.64818473076484 1 9.10049094154315 1509 1159 1123 1449 1725 2553 2016 2173 1635 1219 1934 1437 M14504 GO_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 261/671 Gene Ontology BP GO:0008610 5.13528771687793e-07 2.93634739771727e-06 1880 1643.72727272727 1636 4.66844446869846e-08 661 1.41022949248785 -1.29380450153183 -1 9.24198169928837 1877 1528 1844 2118 669 661 2777 1131 2285 1636 1555 1438 M15455 GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. 27/69 Gene Ontology BP GO:0034637 1.27468984961229e-05 3.0413077963771e-05 1640 1539.09090909091 1637 1.15881566843841e-06 990 1.91042553706396 1.99432758083417 1 10.2223896401225 1637 1793 1343 1827 1821 1728 990 1779 1088 1410 1514 1439 M15727 GO_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMPORT_INTO_CELL.html The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 18/59 Gene Ontology BP GO:0098657 6.48682843888119e-06 1.72895203454221e-05 3050 2078.18181818182 1637 5.8971341506841e-07 155 2.2114624469189 -1.72888326085022 -1 12.4757538701168 3046 1558 1009 907 1637 2355 3975 3561 155 1348 3309 1440 M16457 GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. 13/43 Gene Ontology BP GO:0007212 7.02107687756133e-07 3.49773175348898e-06 760 1603.72727272727 1637 6.38279919842529e-08 149 1.65239939168016 1.37029215133039 1 10.6803236999721 757 1857 1637 1688 807 433 149 3154 3827 2490 842 1441 M16781 GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 180/463 Gene Ontology BP GO:0060249 4.41259825940228e-06 1.26937383633239e-05 2380 1956.54545454545 1637 4.01146100899301e-07 878 1.86875209352278 2.18670010421111 1 10.8394574095797 2380 958 878 2050 1517 4573 2446 1347 1575 1637 2161 1442 M15895 GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. 14/31 Gene Ontology BP GO:0050849 9.45920892453479e-07 4.23520800738814e-06 1445 1629.09090909091 1639 8.59928453786995e-08 928 1.3862412527412 1.67598194424154 1 8.82355916884934 1011 1499 1856 1445 928 1897 2002 1639 2192 2009 1442 1443 M16475 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. 30/90 Gene Ontology BP GO:1902305 1.29525951909416e-07 1.41503292874216e-06 3100 1873.27272727273 1639 1.1775087230483e-08 170 1.67526257315992 -1.51435729002928 -1 11.6080663026733 3099 430 1395 443 170 3118 2598 2696 1639 1634 3384 1444 M12267 GO_ECTODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. 15/39 Gene Ontology BP GO:0007398 1.00038385275258e-07 1.23203772634754e-06 2480 1897.81818181818 1640 9.09439907492752e-09 116 2.52650743660387 2.90694798825706 1 17.6864334710687 2477 1640 1380 1203 116 3791 3094 3156 307 2117 1595 1445 M15761 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 94/249 Gene Ontology BP GO:0007163 5.77707196266561e-07 3.16463969170349e-06 1600 1776.45454545455 1640 5.25188498153785e-08 718 1.59758316043173 1.7222964927768 1 10.4082709442408 1596 2538 1544 1888 718 1608 1112 2718 1810 2369 1640 1446 M15805 GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-6 production. 76/195 Gene Ontology BP GO:0032675 2.65233947417036e-06 8.67102357281965e-06 2595 1803.36363636364 1640 2.41122061078155e-07 866 1.60147863293246 -1.48368271979064 -1 9.60318461341871 2591 2132 1163 974 1328 2054 3599 1137 1640 866 2353 1447 M12217 GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. 227/567 Gene Ontology BP GO:0044283 1.89335783953003e-07 1.74206167729257e-06 4355 2039.09090909091 1642 1.72123454770516e-08 23 1.58486891135476 -1.39015608584196 -1 10.8121899878945 4353 23 950 1642 288 2112 3839 2617 1608 1036 3962 1448 M13823 GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. 99/225 Gene Ontology BP GO:0006352 3.53782540381146e-06 1.07150184930832e-05 1515 2049.27272727273 1642 3.21621008455454e-07 443 1.29923233017871 -1.30320477615405 -1 7.64930243463748 1514 3274 3069 3448 1436 443 1642 1017 2538 3312 849 1449 M11622 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 43/85 Gene Ontology BP GO:0007173 1.39890620169611e-05 3.27540166135907e-05 1630 1695.54545454545 1644 1.2717409972278e-06 812 1.64541551047987 -1.98172835790746 -1 8.74158999617753 1629 1840 1644 1139 1860 1328 2882 1063 1799 2655 812 1450 M12568 GO_NOSE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOSE_DEVELOPMENT.html The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). 5/29 Gene Ontology BP GO:0043584 5.95463471300686e-05 0.000114245326332607 1645 1862.90909090909 1645 5.95479427856008e-06 407 1.69826415357963 -2.10411194422338 -1 7.9308122889141 1645 1726 3933 3097 2800 1065 1508 407 1563 1977 771 1451 M10892 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. 26/70 Gene Ontology BP GO:0032272 7.46234651947996e-07 3.620446696964e-06 1805 1570.81818181818 1646 6.78395368244632e-08 405 1.62385592069907 1.42677780289363 1 10.4670243571328 1802 674 1768 1080 839 1646 1062 3784 405 2207 2012 1452 M12147 GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. 12/22 Gene Ontology BP GO:0045540 0.000109388869726752 0.000196552833646017 1855 1558.90909090909 1647 9.94493719655791e-06 469 1.45964455886941 -1.20639844432654 -1 6.40901855896325 1851 1111 1647 1257 2457 587 967 2520 1936 2346 469 1453 M11037 GO_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMISSION_OF_NERVE_IMPULSE.html The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. 14/102 Gene Ontology BP GO:0019226 4.0093632659454e-05 8.07262517076517e-05 1650 1724.81818181818 1648 3.64494212360305e-06 263 3.06310605498483 3.25870427319133 1 14.8518399984866 1648 2558 999 1398 2184 2940 2904 632 263 1383 2064 1454 M12089 GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM.html The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 12/25 Gene Ontology BP GO:0003159 7.58922297550564e-09 1.60898457877958e-07 3070 2132.18181818182 1648 6.89929363789616e-10 1 1.81814811551136 -1.27495338520603 -1 14.6317938928818 3066 1502 1286 1319 1 4438 3420 1469 1940 1648 3365 1455 M14283 GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. 12/40 Gene Ontology BP GO:0042537 6.66810251373743e-06 1.76510832219401e-05 2905 1855.81818181818 1648 6.06192974958766e-07 248 2.4180154875547 -2.17344675209166 -1 13.6152566177366 2902 469 550 248 1648 4312 3941 2092 724 1116 2412 1456 M13598 GO_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INTERNALIZATION.html A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. 23/81 Gene Ontology BP GO:0031623 8.51456066682517e-08 1.11370228981163e-06 1575 1790.09090909091 1649 7.74050999669126e-09 88 1.36462316815999 1.66530717370562 1 9.62373138204073 1572 1756 1611 2502 88 1539 1576 1649 3146 2424 1828 1457 M14715 GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. 10/44 Gene Ontology BP GO:0002710 0.00213790430269845 0.00306366965352744 1005 1864 1649 0.000194544063169701 971 1.94876640489716 -2.24242681401194 -1 5.80311580064985 1001 2731 1649 2751 3425 1286 1672 971 1643 1375 2000 1458 M12180 GO_WATER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSPORT.html The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/21 Gene Ontology BP GO:0006833 7.28543608089455e-06 1.90356104240818e-05 3040 2036.18181818182 1650 6.62314564288965e-07 424 3.10508601685071 2.66559257563185 1 17.3633512373188 3040 1280 424 992 1667 3018 1339 3929 1352 1650 3707 1459 M10465 GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 27/64 Gene Ontology BP GO:0071364 7.10759704192474e-06 1.8647838052843e-05 2160 1351.63636363636 1651 6.46147273156969e-07 102 2.0284058388036 2.17176550360622 1 11.3641333266567 2158 116 532 102 1662 2945 2108 1651 213 613 2768 1460 M12416 GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. 12/27 Gene Ontology BP GO:1901533 0.0010706150971282 0.00159680883262649 435 1704.63636363636 1653 9.73760418138356e-05 402 1.11153718716392 -1.11153718716392 -1 3.68260461058846 434 1765 2086 2432 3296 402 781 1229 3710 1653 963 1461 M14360 GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 29/68 Gene Ontology BP GO:0030166 6.75696678113279e-06 1.78456181824798e-05 660 1811.18181818182 1653 6.14271594020187e-07 399 1.66641801059587 1.50722228694805 1 9.37379663113798 656 1971 1549 2846 1653 759 399 3259 2747 2892 1192 1462 M10801 GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. 18/45 Gene Ontology BP GO:0040020 6.7870285686087e-06 1.7914822992638e-05 3280 1743.54545454545 1654 6.1700450061549e-07 470 2.12393799336224 -2.21430893999866 -1 11.9431713248936 3278 824 1518 505 1654 2979 2351 1509 470 1872 2219 1463 M14240 GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. 51/152 Gene Ontology BP GO:0043255 5.90935094418546e-06 1.60544859179948e-05 620 1393.45454545455 1654 5.37215165197021e-07 158 1.65801879496318 1.81376286091191 1 9.41677218494382 619 2390 1654 2252 1972 878 626 158 1809 2455 515 1464 M13645 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. 18/34 Gene Ontology BP GO:1900078 4.25431831718776e-05 8.49582793406571e-05 1085 1548.09090909091 1656 3.86763689874242e-06 644 1.2430876500901 1.31631111047198 1 5.99458176846322 1082 922 2319 1669 2200 1081 644 1656 1713 2443 1300 1465 M16742 GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. 9/18 Gene Ontology BP GO:2001275 0.00161385823883959 0.00235485348929359 975 2026.27272727273 1657 0.00016150314804862 431 1.01512727198448 1.12303774429553 1 3.16031006275878 974 1657 4614 2257 3035 687 431 1315 2692 3517 1110 1466 M10826 GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 116/257 Gene Ontology BP GO:0046395 6.52394772436156e-06 1.73685144978273e-05 1195 1663.27272727273 1658 5.9308791552339e-07 940 1.68153630165891 -1.72557050525341 -1 9.48228222770914 1192 1964 1368 2657 1638 940 1907 972 2113 1887 1658 1467 M13128 GO_ORGANIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. 116/257 Gene Ontology BP GO:0016054 6.52394772436156e-06 1.73685144978273e-05 1195 1669.63636363636 1659 5.9308791552339e-07 941 1.68153630165891 -1.72557050525341 -1 9.48228222770914 1193 1965 1369 2658 1639 941 1908 1032 2114 1888 1659 1468 M15390 GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 9/22 Gene Ontology BP GO:0046135 8.48647534529376e-05 0.000156546305237183 1180 1822.72727272727 1659 8.48679945390102e-06 834 2.19335900903036 2.78072159027378 1 9.88742443343458 1177 2479 4394 1205 2413 1659 1699 1174 834 1923 1093 1469 M11621 GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). 28/58 Gene Ontology BP GO:0007223 2.15666574717075e-05 4.74793696733703e-05 965 1544.81818181818 1660 1.9606244448287e-06 440 1.56178630448976 1.56552466998216 1 7.9989795612791 965 440 2007 1967 1988 1247 1014 1660 2892 1949 864 1470 M15065 GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 12/32 Gene Ontology BP GO:0050995 4.85210995593266e-06 1.36867232839583e-05 3475 1790.09090909091 1660 4.41101877937834e-07 844 1.2139524677917 -1.63318811967636 -1 6.994336210362 3471 844 1536 1375 1550 1716 2201 1367 1869 1660 2102 1471 M10148 GO_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_FIBER_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. 13/22 Gene Ontology BP GO:0043149 0.000489800748580901 0.000779473954755057 1270 1851.45454545455 1661 4.45372572914955e-05 690 1.40895229207921 1.52511585797061 1 5.18779707752239 1270 2161 2269 1462 3089 1661 1942 690 824 3740 1258 1472 M10186 GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 44/102 Gene Ontology BP GO:0070373 8.16553299141725e-06 2.09115111302539e-05 885 1747.45454545455 1661 7.42323936255927e-07 870 1.22686923566607 1.2491991347052 1 6.8012126885363 881 1473 2543 2287 1696 926 1027 870 3132 2726 1661 1473 M11075 GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. 13/22 Gene Ontology BP GO:0030038 0.000685961765306297 0.00106128639664016 1275 1858.81818181818 1662 6.23796129223982e-05 760 1.40895229207921 1.52511585797061 1 4.96409005752182 1271 2162 2270 1463 3090 1662 1943 760 825 3742 1259 1474 M12548 GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 6/13 Gene Ontology BP GO:0043650 7.85877807393559e-05 0.000146120155484484 2485 1624.90909090909 1663 7.85905600953684e-06 61 2.00726771232286 -1.48634651918118 -1 9.1197202052018 2481 181 3929 904 2392 3015 2006 484 61 758 1663 1475 M16484 GO_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 61/170 Gene Ontology BP GO:0046165 2.21204137343739e-06 7.70480727447095e-06 2260 1649.63636363636 1663 2.01094872508107e-07 534 1.4913791172118 -1.32213511475911 -1 9.0336259697173 2256 534 1538 2187 1242 1000 1663 909 2415 2051 2351 1476 M15335 GO_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERTILIZATION.html The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). 57/221 Gene Ontology BP GO:0009566 4.89742399366665e-07 2.87468262991078e-06 1485 1718.72727272727 1664 4.45220462171221e-08 488 1.71465172451744 -1.79297027683025 -1 11.255745087609 1482 3425 1994 3624 642 537 1664 488 2378 2153 519 1477 M10173 GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 7/20 Gene Ontology BP GO:0061000 2.62834110356545e-05 5.61850264450018e-05 3160 2065.54545454545 1665 2.62837219087924e-06 450 2.12873216109199 2.24509966690095 1 10.7183208699584 3159 1665 3548 1483 2084 3352 1197 774 450 1491 3518 1478 M13753 GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 15/48 Gene Ontology BP GO:0070873 9.39488189608856e-05 0.000171666417329946 875 1725.63636363636 1665 8.54116647199418e-06 454 1.68492641796952 1.94669447616071 1 7.5155404902134 874 2810 1890 1768 3420 1241 1021 454 1665 2723 1116 1479 M13943 GO_LIPID_PARTICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. 6/19 Gene Ontology BP GO:0034389 1.74007827806549e-06 6.43759637056421e-06 995 1613 1666 1.74007964060958e-07 46 0.889506716608584 -0.889506716608584 -1 5.47017651466919 992 1666 4161 2075 2199 214 513 450 2284 3143 46 1480 M14733 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 45/93 Gene Ontology BP GO:0090003 4.94828671363226e-07 2.88438570216643e-06 4455 2436.18181818182 1667 4.49844347873796e-08 545 1.4023869629961 -1.21021332878286 -1 9.20346726165597 4451 545 1517 718 647 4071 3857 4514 1183 1667 3628 1481 M11344 GO_THYROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. 3/17 Gene Ontology BP GO:0042403 2.56612381965146e-06 8.48933831581019e-06 2025 1750.45454545455 1669 2.56612678290244e-07 93 3.41762885895226 -3.41762885895226 -1 20.5308712418278 2025 1669 3733 917 2994 1656 2742 106 93 2580 740 1482 M11712 GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 28/69 Gene Ontology BP GO:0070849 7.30887653595127e-06 1.90539661742963e-05 2090 1345.72727272727 1669 6.64445528885019e-07 108 2.0284058388036 2.17176550360622 1 11.3416497712908 2090 113 595 108 1669 2810 2099 1690 220 643 2766 1483 M12116 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that modulates the activity of the enzyme nitric-oxide synthase. 33/73 Gene Ontology BP GO:0050999 2.36836893241108e-06 7.99733596595245e-06 1365 1778.54545454545 1669 2.15306498367116e-07 1165 1.66778746443443 1.9919602966361 1 10.0701983588292 1363 2260 1247 2225 1285 1669 1749 1549 2716 2336 1165 1484 M11263 GO_IMMUNE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 383/940 Gene Ontology BP GO:0002520 3.31642324617299e-07 2.3836150359104e-06 1575 1778.36363636364 1670 3.01493067828393e-08 468 1.55604186201038 1.79449114842637 1 10.3645190562943 1574 2125 739 1670 468 3445 2645 1830 2150 1320 1596 1485 M11347 GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM.html The process in which an organism effects a change in the structure or processes of a second organism. 55/206 Gene Ontology BP GO:0035821 2.73223296527946e-05 5.79258340538472e-05 1185 2096 1670 2.48387899829858e-06 1127 1.8363789258574 2.01832625224304 1 9.21747304308558 1185 4225 1670 3263 2061 1598 1224 1557 2438 2708 1127 1486 M16536 GO_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 55/235 Gene Ontology BP GO:0042445 8.81084876728642e-07 4.03837816648676e-06 1200 2460.09090909091 1672 8.0098657236116e-08 654 1.72630968800035 -1.43862488367126 -1 11.0303938542112 4120 654 960 1199 898 3544 4304 4203 1200 1672 4307 1487 M10061 GO_L_PHENYLALANINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. 7/12 Gene Ontology BP GO:0006558 3.50577903858995e-06 1.06596804690066e-05 2010 1945 1675 3.50578456932123e-07 1412 1.2268307809632 -1.3273374927516 -1 7.22630235031892 2006 1514 3528 1903 1470 1675 3078 1573 1746 1490 1412 1488 M10333 GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. 21/51 Gene Ontology BP GO:0031109 3.6058359755816e-05 7.34293703273043e-05 520 1537.09090909091 1676 3.27808643379914e-06 516 1.57921795393483 1.80997378879782 1 7.73400110418214 516 2313 1787 2266 2152 1012 960 1230 2138 1676 858 1489 M13543 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 7/12 Gene Ontology BP GO:1902222 3.50577903858995e-06 1.06596804690066e-05 2010 1986.09090909091 1676 3.50578456932123e-07 1413 1.2268307809632 -1.3273374927516 -1 7.22630235031892 2007 1515 4094 1904 1471 1676 3079 1439 1747 1502 1413 1490 M16112 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 7/12 Gene Ontology BP GO:1902221 3.50577903858995e-06 1.06596804690066e-05 1520 2036.90909090909 1677 3.50578456932123e-07 1414 1.2268307809632 -1.3273374927516 -1 7.22630235031892 2008 1516 4510 1905 1472 1677 3080 1560 1748 1516 1414 1491 M15641 GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 81/250 Gene Ontology BP GO:0050777 1.66435881638415e-06 6.25718055422804e-06 3780 2448.54545454545 1678 1.51305461410675e-07 385 1.84495905775044 -1.60565570006553 -1 11.3728799344466 3777 1678 590 1150 1141 3907 4585 3965 1277 385 4479 1492 M16388 GO_L_PHENYLALANINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. 7/12 Gene Ontology BP GO:0006559 3.50577903858995e-06 1.06596804690066e-05 1520 2042.36363636364 1678 3.50578456932123e-07 1415 1.2268307809632 -1.3273374927516 -1 7.22630235031892 2009 1517 4556 1906 1473 1678 3081 1563 1749 1519 1415 1493 M11478 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. 21/48 Gene Ontology BP GO:1902883 3.78931473715591e-06 1.1305000062821e-05 2275 1845.72727272727 1679 3.44483751267926e-07 895 1.73969745069193 -1.72977551357232 -1 10.1945935073994 2275 1183 1930 895 1461 2055 1337 4040 1145 1679 2303 1494 M11583 GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 21/49 Gene Ontology BP GO:0051023 0.00295134968479073 0.0041618071750249 1190 1830 1680 0.000268665130830446 1126 1.99439564430751 -1.92076340800731 -1 5.62467265798764 1187 2314 1545 1591 3119 1126 1988 2045 1630 1680 1905 1495 M11892 GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. 154/400 Gene Ontology BP GO:1901565 1.86307948436365e-07 1.73572332354834e-06 3175 1986.18181818182 1680 1.69370876558123e-08 280 1.68522084475894 1.94568131222849 1 11.4999648163317 3174 750 500 1304 280 3859 4020 2492 1680 785 3004 1496 M15990 GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. 62/167 Gene Ontology BP GO:0072593 2.13601983297098e-07 1.8810845092294e-06 3415 2006.45454545455 1680 1.94183640032822e-08 322 1.56474202525005 -1.70780353258951 -1 10.6130730571327 3411 1680 1336 1374 322 1583 3320 1621 2484 2148 2792 1497 M16386 GO_SIGNAL_PEPTIDE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_PEPTIDE_PROCESSING.html The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. 13/30 Gene Ontology BP GO:0006465 0.0289082417726496 0.0366323598663789 1170 2110.09090909091 1680 0.00266320340719165 1048 1.40902888372423 -1.40902888372423 -1 2.39713774593648 1169 3555 2486 3561 3590 1139 1048 1680 1602 1857 1524 1498 M10665 GO_KERATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 17/38 Gene Ontology BP GO:0042339 2.44753968319678e-05 5.29293281280049e-05 1520 1574.63636363636 1682 2.22506082994668e-06 459 2.01753568635484 2.27799317038786 1 10.2203975260944 1517 459 1024 1940 2018 2070 1682 1886 1394 1788 1543 1499 M15328 GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 7/18 Gene Ontology BP GO:0060457 0.00104143923718884 0.0015572954519381 830 1925.90909090909 1683 0.000104192762740928 86 3.49073934228116 3.49073934228116 1 11.6100790492681 826 3533 4388 1274 3569 1749 1683 920 86 2398 759 1500 M10567 GO_RESPONSE_TO_AMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. 30/77 Gene Ontology BP GO:0014075 4.40001521034334e-06 1.26732448024964e-05 2080 1829.81818181818 1684 4.00002182766257e-07 597 2.21087496242246 2.3982699587972 1 12.825735473316 2076 2141 1307 1280 1516 2881 1549 2545 597 2552 1684 1501 M12807 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. 37/94 Gene Ontology BP GO:1904427 6.43905024267219e-08 9.22731798664412e-07 2355 1680.09090909091 1684 5.85368221012086e-09 57 1.70478266516943 1.7514873741268 1 12.1876199922959 2353 1684 1112 2079 57 3054 2302 858 2254 1129 1599 1502 M13307 GO_CELL_DIFFERENTIATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_HINDBRAIN.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. 14/41 Gene Ontology BP GO:0021533 0.00022044475094215 0.00037354926227168 1225 1831.18181818182 1685 2.0042440280133e-05 672 1.41691084247862 -1.41691084247862 -1 5.75330285432597 1222 1642 1295 2316 2611 1130 2388 1685 3179 2003 672 1503 M10848 GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. 30/98 Gene Ontology BP GO:2000737 1.04223243003643e-06 4.52699153631691e-06 2995 1874.27272727273 1686 9.47484476169137e-08 445 1.66849231468672 1.83612217825323 1 10.5629240943784 2995 1686 1499 888 961 4273 2481 1692 445 1628 2069 1504 M11009 GO_SERTOLI_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. 14/21 Gene Ontology BP GO:0060009 2.8403011003466e-07 2.17485745049544e-06 2360 1938.63636363636 1687 2.582092242766e-08 415 2.21833310655589 2.12153880907169 1 14.8805278127511 2359 1425 1010 1687 415 3069 2632 4405 463 931 2929 1505 M16328 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. 25/69 Gene Ontology BP GO:0051155 4.26369044988966e-06 1.24037059892467e-05 2630 2068.36363636364 1687 3.87608973919951e-07 913 1.83165562250301 -1.71743795325216 -1 10.6460647782089 2629 1687 1007 1100 1504 3179 2440 4354 1094 913 2845 1506 M10035 GO_LACTATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSPORT.html The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 4/13 Gene Ontology BP GO:0015727 0.000498195570742553 0.000791893883929364 1385 1949.81818181818 1688 4.98307295467999e-05 711 2.75108454005881 2.75108454005881 1 10.1071885518933 1381 2376 3521 1947 3355 1489 1340 711 873 2767 1688 1507 M10589 GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 49/133 Gene Ontology BP GO:0032481 2.35083061554099e-07 1.96311268848144e-06 1690 1868.72727272727 1688 2.13711896976476e-08 358 1.08537791619441 -1.25121497200111 -1 7.33788706627095 1688 2460 3158 3270 358 498 1002 756 2826 3633 907 1508 M15700 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. 21/48 Gene Ontology BP GO:1900408 3.78931473715591e-06 1.1305000062821e-05 2280 1845.45454545455 1688 3.44483751267926e-07 896 1.73969745069193 -1.72977551357232 -1 10.1945935073994 2276 1184 1931 896 1462 2056 1338 4019 1146 1688 2304 1509 M13665 GO_LACTATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 4/13 Gene Ontology BP GO:0035873 0.000496536216661201 0.000789797072270625 1385 2006.27272727273 1689 4.96647198260005e-05 710 2.75108454005881 2.75108454005881 1 10.110941170181 1382 2377 4112 1948 3356 1490 1341 710 874 2790 1689 1510 M15948 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of lamellipodium organization. 21/46 Gene Ontology BP GO:1902745 2.60205892186252e-06 8.56226759334351e-06 4175 2298.36363636364 1690 2.36551090860306e-07 717 1.52273673729934 -1.68638748786565 -1 9.14090077351718 4174 813 1615 717 1323 4105 4240 2582 1065 1690 2958 1511 M16851 GO_ESTROUS_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROUS_CYCLE.html A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. 11/25 Gene Ontology BP GO:0044849 7.98910382656429e-06 2.05389861942071e-05 2120 1708.90909090909 1690 7.26284803493631e-07 162 2.00524752923679 2.03608403452267 1 11.1347376025544 2117 1353 1344 876 1690 3311 3090 1814 162 992 2049 1512 M10849 GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. 18/53 Gene Ontology BP GO:0002701 0.000956624757611115 0.00144067750554278 1350 1718.72727272727 1694 8.70037254196452e-05 781 1.80502928437636 -1.93677340534144 -1 6.07574709601793 1346 2507 1802 2198 2916 781 1370 1173 1694 1873 1246 1513 M12330 GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 31/78 Gene Ontology BP GO:0045661 1.63367355192837e-06 6.18186332649014e-06 2765 2084.63636363636 1694 1.48515887732829e-07 494 1.8932395853018 1.95932381298945 1 11.6822909476323 2762 1165 954 1694 1130 4055 3053 3134 1345 494 3145 1514 M13757 GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR.html The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 12/22 Gene Ontology BP GO:0042994 3.16777104028357e-06 9.88438235217516e-06 1695 2036.90909090909 1694 2.87979600141217e-07 846 0.849887579911263 -0.719831835193575 -1 5.03904109198013 1694 1428 2940 1925 1394 846 1019 3881 2842 3052 1385 1515 M11285 GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. 11/27 Gene Ontology BP GO:0007176 0.00318001748451018 0.00446067105153498 1115 2085.36363636364 1697 0.000289511218542494 1038 1.31174584357762 -1.31174584357762 -1 3.65263514706714 1115 1578 2822 2499 3143 1038 1697 1052 3203 3645 1147 1516 M12808 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. 34/90 Gene Ontology BP GO:0010633 1.75836257279865e-05 3.99807905264649e-05 125 1237.72727272727 1697 1.59852420615387e-06 64 1.41581317824516 1.50602460325096 1 7.37655957191163 124 2259 1746 1847 2790 177 64 256 1697 2432 223 1517 M11415 GO_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 331/883 Gene Ontology BP GO:0001775 6.34453944163033e-07 3.29873422480287e-06 1700 1667.18181818182 1698 5.76776479211008e-08 321 1.67164446245235 1.94930746296042 1 10.8550908573441 1698 1598 321 1063 764 3738 2410 2036 1698 395 2618 1518 M12291 GO_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by the detection of a hormone. 66/264 Gene Ontology BP GO:0009755 9.7202284037778e-06 2.41342355501285e-05 3040 2009.63636363636 1699 8.83661031889909e-07 893 1.7409039983593 -1.58934597927291 -1 9.5224168917741 3036 2425 1265 1240 1754 1699 3720 3217 893 1178 1679 1519 M10796 GO_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 646/1734 Gene Ontology BP GO:0051336 1.18801071040556e-07 1.3519445412777e-06 1490 1542.36363636364 1700 1.18801077391719e-08 3 1.64285992336706 1.76864084594235 1 11.4220938871375 1490 3 3638 743 174 2935 1906 1700 1904 295 2178 1520 M11642 GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 6/27 Gene Ontology BP GO:0034035 7.54593155915702e-06 1.96059094735121e-05 2635 1732.63636363636 1700 7.54595718276686e-07 119 1.58790932838249 -1.51896657582112 -1 8.85532435662839 2632 182 3780 789 1700 1214 2036 4139 119 755 1713 1521 M11735 GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. 6/17 Gene Ontology BP GO:0060389 1.18530630396933e-05 2.86278695462113e-05 1415 1949.27272727273 1700 1.18531262629644e-06 112 1.7856860013383 1.7856860013383 1 9.61050090785165 1411 3928 3797 1700 3688 1704 1335 223 112 3118 426 1522 M14007 GO_MICROTUBULE_BUNDLE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BUNDLE_FORMATION.html A process that results in a parallel arrangement of microtubules. 45/140 Gene Ontology BP GO:0001578 1.017660874288e-06 4.47019814505127e-06 1180 1869.90909090909 1700 9.25146677300795e-08 948 1.61674049001528 1.46381022858169 1 10.2457935386153 1930 2393 2078 2803 948 1637 1270 1179 1177 3454 1700 1523 M14245 GO_SMALL_MOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. 178/427 Gene Ontology BP GO:0044282 1.48088372528663e-06 5.81304568968258e-06 1465 1707.90909090909 1701 1.34625883828482e-07 883 1.55569361293082 -1.50415276295649 -1 9.64868756567909 1464 2297 1371 2564 1089 883 1830 1370 2409 1809 1701 1524 M16940 GO_REGULATION_OF_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of T cell migration. 15/35 Gene Ontology BP GO:2000404 0.0018264760662587 0.00263773821948341 1410 1812.54545454545 1701 0.000166181291041636 1161 1.90176176769222 2.23039690654428 1 5.80960241977194 1408 1498 1161 1256 3039 2234 2265 1701 2086 1478 1812 1525 M13000 GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. 104/204 Gene Ontology BP GO:0007265 2.80421353261307e-07 2.15562308475538e-06 2850 2066.81818181818 1703 2.54928535459101e-08 412 1.50158379832289 1.76373883707243 1 10.0794518473907 2846 1067 1038 1479 412 4311 2905 1703 1848 1156 3970 1526 M12753 GO_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_INFLAMMATORY_RESPONSE.html Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. 33/158 Gene Ontology BP GO:0002526 1.55097671714554e-06 6.0059924084293e-06 4040 1812.72727272727 1704 1.40997982778981e-07 325 2.14870249205654 -1.86929732172447 -1 13.2905381096596 4040 424 325 572 1704 2927 2942 2856 804 432 2914 1527 M13403 GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 15/38 Gene Ontology BP GO:0045662 4.16405571683966e-06 1.21726937563556e-05 2180 2034.90909090909 1704 3.78551236217075e-07 487 1.98304683680398 1.9511016930711 1 11.5451707956625 2180 1704 1198 1287 1495 3787 3281 3575 487 710 2680 1528 M10933 GO_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. 65/161 Gene Ontology BP GO:0010469 6.31816002013398e-07 3.28870145442624e-06 1765 1351.36363636364 1706 5.74378348603759e-08 80 1.45600334092221 1.81961182704127 1 9.45707221075507 1764 80 1706 446 763 1954 1862 882 1804 2299 1305 1529 M13946 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. 4/13 Gene Ontology BP GO:0040015 5.77666225701544e-06 1.57678088532173e-05 2895 1826.36363636364 1706 5.77667727349246e-07 348 1.4488062484251 -1.81579106739191 -1 8.24197244266861 2895 348 4162 1832 1627 1108 1174 1837 819 1706 2582 1530 M15725 GO_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_NUCLEATION.html The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. 13/25 Gene Ontology BP GO:0045010 1.19798511533471e-06 4.9965450210294e-06 1410 1550.27272727273 1706 1.08907797062223e-07 65 1.91234424152077 -1.91234424152077 -1 12.0096117741669 1406 1861 2266 1014 2497 1706 2629 65 530 2486 593 1531 M13278 GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. 11/23 Gene Ontology BP GO:0070233 0.00152157616609179 0.00222439488008948 1890 1944 1707 0.000138420867919878 1348 1.73213176538874 -1.65209564178127 -1 5.44328979856931 1890 2071 1570 2367 2998 1616 1707 1348 1671 1540 2606 1532 M15457 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 267/655 Gene Ontology BP GO:0007169 4.06416424555789e-07 2.61980478260637e-06 1715 1523.81818181818 1707 3.69469545122764e-08 422 1.58765551461599 1.67229411375698 1 10.4979189741251 1715 1142 422 676 563 2949 2295 2306 1707 587 2400 1533 M14434 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. 11/34 Gene Ontology BP GO:0060045 8.53571868619481e-06 2.17277093530716e-05 1665 1851.18181818182 1708 7.75977436715613e-07 1019 2.81300667596936 3.57343538111127 1 15.5386374706008 1662 1284 1019 1461 1708 2877 3162 1905 1275 2240 1770 1534 M11981 GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. 459/1152 Gene Ontology BP GO:0051345 1.2067821811435e-07 1.35993553410173e-06 1715 1500.72727272727 1711 1.0970747703091e-08 7 1.62574184914962 1.71985482610625 1 11.2981501201789 1711 7 324 524 151 3536 2520 2560 2025 312 2838 1535 M12722 GO_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. 242/660 Gene Ontology BP GO:0050708 1.56561114445156e-05 3.61828399387186e-05 1355 1595.18181818182 1711 1.42329298736371e-06 466 1.56431759784636 1.60507546957095 1 8.23061620797645 1354 1960 544 1333 1887 1711 1215 2538 2574 466 1965 1536 M16273 GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 35/95 Gene Ontology BP GO:0014068 0.00100287392825304 0.00150350133964445 1715 1741.81818181818 1711 9.12119438267435e-05 839 2.02766375602513 2.40455009365266 1 6.7806111334934 1020 2753 839 1711 2928 1714 2609 1039 2056 1639 852 1537 M14712 GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT.html The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. 6/16 Gene Ontology BP GO:0072531 0.000326837381635041 0.000533769244787723 2035 1754.81818181818 1712 3.26885461791104e-05 125 1.51393963487475 -0.636293351867506 -1 5.8692907894492 2034 947 4279 1360 2709 2043 1137 1712 125 2193 764 1538 M10577 GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. 12/18 Gene Ontology BP GO:0008535 0.000113543130406078 0.000203387636757493 1190 2224.54545454545 1713 1.03226355317117e-05 953 0.687579296962106 -0.687579296962106 -1 3.0069358558899 1189 1713 3185 3253 2463 953 1171 1187 3705 4207 1444 1539 M15399 GO_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MIGRATION.html The movement of a lymphocyte within or between different tissues and organs of the body. 18/74 Gene Ontology BP GO:0072676 5.15590412527853e-05 0.000100880163732272 1715 2150.36363636364 1714 4.68729542058209e-06 1403 1.4325698918671 1.77462188824281 1 6.7817285255396 1714 2699 1708 3211 2255 1523 1403 1551 3722 2449 1419 1540 M10618 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. 11/24 Gene Ontology BP GO:1901032 9.29008386383197e-07 4.19986475613013e-06 4355 2325.81818181818 1715 8.44553435165343e-08 686 1.93570155340219 -1.85694063765433 -1 12.329273075951 4352 1715 1721 1324 916 4083 4345 713 686 1527 4202 1541 M13557 GO_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAT_CASCADE.html An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 25/85 Gene Ontology BP GO:0097696 3.47742725234249e-06 1.06151839136267e-05 4230 2612 1718 3.16130249904154e-07 123 1.48078535890719 -1.66157841741407 -1 8.72533758226346 4228 123 1718 1527 1425 4044 4431 4001 1513 1186 4536 1542 M14003 GO_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE.html Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 25/85 Gene Ontology BP GO:0007259 3.47742725234249e-06 1.06151839136267e-05 4230 2613.63636363636 1719 3.16130249904154e-07 124 1.48078535890719 -1.66157841741407 -1 8.72533758226346 4229 124 1719 1528 1426 4045 4432 4009 1514 1187 4537 1543 M16156 GO_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the cell. 336/901 Gene Ontology BP GO:0019725 4.2538173871576e-07 2.67621600658167e-06 1605 1835.18181818182 1719 3.86710746332374e-08 343 1.61221020631153 1.691221351118 1 10.6426094926491 1603 1527 343 1719 585 2777 2477 3983 2675 426 2072 1544 M10760 GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 822/2178 Gene Ontology BP GO:0010647 1.24803100453773e-07 1.38296132555338e-06 1675 1780.45454545455 1721 1.24803107462889e-08 151 1.60403049707433 1.78843815890003 1 11.1334108534076 1674 950 3629 1161 190 3385 2570 2147 2007 151 1721 1545 M12588 GO_REGULATION_OF_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESODERM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of mesoderm development. 10/28 Gene Ontology BP GO:2000380 0.000231938808838898 0.000391454703540169 2120 1988.09090909091 1722 2.10875695453742e-05 191 3.17477271590377 -0.790776269138314 -1 12.8145515718927 2116 3407 1722 3135 3435 1221 191 576 1256 3577 1233 1546 M14610 GO_REGULATION_OF_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROVILLUS_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. 11/32 Gene Ontology BP GO:0032530 3.69586647791983e-05 7.51309459587644e-05 1725 1578.63636363636 1722 3.35993506153989e-06 330 1.94329123785936 -2.38264712993747 -1 9.49409666908781 1722 1649 1908 1730 2700 1185 2480 330 475 2241 945 1547 M14207 GO_GOLGI_TO_VACUOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_VACUOLE_TRANSPORT.html The directed movement of substances from the Golgi to the vacuole. 21/38 Gene Ontology BP GO:0006896 8.90312293518373e-06 2.24188548050892e-05 1465 2327.72727272727 1723 8.09378087745921e-07 1019 0.934210284902948 -0.955804581546887 -1 5.14538956310694 1462 3877 3186 3806 1723 1024 1595 1019 3336 3257 1320 1548 M15691 GO_POSITIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_STORAGE.html Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 13/29 Gene Ontology BP GO:0010884 0.00194871672628777 0.00280728878689237 1300 1934.36363636364 1723 0.000177313182258017 1257 1.26767428444495 -1.33336193627022 -1 3.83192854658587 1299 1570 1728 2357 3051 1516 1776 1632 3369 1257 1723 1549 M10957 GO_SPHINGOMYELIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOMYELIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. 6/14 Gene Ontology BP GO:0006684 0.000809655012094681 0.00123545306939178 740 2048.27272727273 1724 8.09950157008147e-05 558 1.13720401119866 -1.13720401119866 -1 3.91774935495188 737 1724 3663 2896 2903 670 558 1705 3645 3114 916 1550 M12213 GO_RESPONSE_TO_GLUCAGON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GLUCAGON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 27/61 Gene Ontology BP GO:0033762 8.90380535442268e-06 2.24188548050892e-05 2480 1767 1724 8.09440126360698e-07 697 1.81521092926761 1.52302842184037 1 9.99771572079249 2479 1091 697 797 1724 2395 1315 2267 2307 1007 3358 1551 M10299 GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION.html The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 8/22 Gene Ontology BP GO:0086069 0.000641207413317416 0.000997362150764745 2780 2161.63636363636 1725 6.41392504613147e-05 1029 1.63277499488609 1.11775128505811 1 5.80485801871963 2777 1029 3563 1541 2844 2081 1144 1513 1672 1725 3889 1552 M10528 GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/20 Gene Ontology BP GO:0010766 5.78644439274983e-06 1.57852299151219e-05 1665 2564.36363636364 1726 5.78645946012747e-07 1226 1.59856738608074 -1.50785786042792 -1 9.09302598528481 4527 1661 3599 1332 1628 4178 2980 1226 1662 1726 3689 1553 M16672 GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. 13/37 Gene Ontology BP GO:0032897 4.79873786038787e-07 2.85282200842265e-06 545 1425 1727 4.36248991555476e-08 142 1.22561741378475 1.22561741378475 1 8.05031678770741 545 1908 2513 1727 634 377 142 2661 2383 2492 293 1554 M10804 GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 8/15 Gene Ontology BP GO:0044090 0.000311839461140795 0.000512366873595874 1230 1914.81818181818 1728 3.11883229517509e-05 872 1.10473032594814 -1.1104575500706 -1 4.30611284447326 1228 1509 3640 1579 2697 1097 1756 3009 872 1728 1948 1555 M10913 GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. 8/16 Gene Ontology BP GO:0033240 1.22906426097389e-07 1.37176571242831e-06 3100 1642.45454545455 1729 1.22906432895084e-08 95 1.5597802004456 -0.799127876415147 -1 10.8327967468251 3097 169 3658 589 184 2085 1464 1735 95 1729 3262 1556 M12615 GO_CHLORIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_TRANSPORT.html The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/116 Gene Ontology BP GO:0006821 4.97426531872729e-07 2.89304927155986e-06 3385 2088.36363636364 1729 4.52206040311255e-08 650 1.59756879937902 -1.95731822273893 -1 10.4819254585809 3383 998 1729 2387 650 3413 3118 1210 1035 1434 3615 1557 M14710 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 614/1522 Gene Ontology BP GO:0031401 2.88843198498607e-07 2.19492466551396e-06 1480 1875.18181818182 1729 2.8884323604229e-08 372 1.52865946410549 1.64067935191725 1 10.2469889835395 1478 1729 4277 1403 455 2729 2264 2257 2305 372 1358 1558 M13421 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. 79/302 Gene Ontology BP GO:0021953 3.84165641533389e-07 2.57804519639595e-06 1730 1517.45454545455 1730 3.49241553287906e-08 429 1.81196320705847 1.86972598322667 1 11.9960688366362 1730 1382 429 566 518 2630 1978 2599 1787 504 2569 1559 M13495 GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 356/869 Gene Ontology BP GO:0051347 5.08140971261964e-07 2.91631462245896e-06 1735 1818.09090909091 1732 4.61946444208121e-08 665 1.53429799262724 1.6309994209552 1 10.0604722246288 1732 1918 1117 1065 665 3510 2797 2662 2105 926 1502 1560 M10757 GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of an adaptive immune response. 77/220 Gene Ontology BP GO:0002819 7.98105799985895e-06 2.0529668860579e-05 1820 1907.27272727273 1733 7.25553359392562e-07 1092 1.72267486124102 -1.71738369614682 -1 9.56607011807122 1819 2886 1220 2916 1689 1187 2492 1092 2477 1469 1733 1561 M12328 GO_OVARIAN_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVARIAN_FOLLICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. 31/77 Gene Ontology BP GO:0001541 0.000143455903375969 0.000251061349180031 1735 2525.36363636364 1733 1.30422962356303e-05 1331 1.80168453686103 -1.92237347682575 -1 7.68397273273527 3877 1549 1688 1733 2517 3282 4630 1587 1733 1331 3852 1562 M11860 GO_PEPTIDYL_PROLINE_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_HYDROXYLATION.html The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. 8/13 Gene Ontology BP GO:0019511 0.000329979015909645 0.000538331894191314 1020 1747.18181818182 1734 3.30028024920109e-05 645 1.42456952062333 1.6341257101869 1 5.5165794920934 1016 2735 3817 2032 2711 684 645 1020 2161 1734 664 1563 M11861 GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 29/115 Gene Ontology BP GO:0033555 0.00174078106064724 0.00252576452018285 3075 1938.54545454545 1734 0.000158378182366784 652 2.17044614662216 2.20259246325232 1 6.6788313412556 1108 3114 652 2171 3073 1734 1207 3072 2258 1563 1372 1564 M12758 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of cellular response to hypoxia. 10/15 Gene Ontology BP GO:1900037 5.40880685354818e-06 1.49393755032862e-05 1285 1767.54545454545 1734 4.917109228553e-07 80 2.40348165607191 2.40348165607191 1 13.7396686766028 1282 3530 2088 1734 3214 1254 1145 398 1896 2822 80 1565 M16269 GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 428/1010 Gene Ontology BP GO:0051129 2.70091078728332e-07 2.10849698183809e-06 1735 1970.54545454545 1734 2.45537374442783e-08 402 1.51855771909193 1.61272523431465 1 10.2106593584757 1734 3168 1546 2730 402 2172 1494 1432 2654 3067 1277 1566 M15867 GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 11/28 Gene Ontology BP GO:0048261 2.18954379181132e-05 4.81347150822914e-05 1740 1857.90909090909 1737 1.99051416680705e-06 1022 0.933496599523867 -0.961588344365731 -1 4.77449254042392 1737 1022 2728 2218 1991 1275 1193 1569 2377 2947 1380 1567 M16571 GO_COFACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. 105/181 Gene Ontology BP GO:0051188 1.17668225790324e-06 4.9407468605345e-06 1740 1717.45454545455 1737 1.0697117156898e-07 205 1.14577676211518 -0.986267177057607 -1 7.20215113796273 455 1737 3310 3246 1006 205 511 1738 2331 3788 565 1568 M12738 GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. 2/14 Gene Ontology BP GO:0007210 0.00295171893761727 0.0041618071750249 1635 2086.7 1738 0.000328399826236259 343 3.36354643817181 3.36354643817181 1 9.48600647078411 1632 3133 3953 NA 3531 1607 1453 1080 343 2291 1844 1569 M10725 GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. 10/44 Gene Ontology BP GO:0007202 9.37139635057931e-06 2.33932221805052e-05 2795 2191.90909090909 1740 8.51948751854042e-07 737 2.70738896418558 -2.81290316552795 -1 14.8523454960148 2795 939 1032 1683 1740 3469 2865 3562 737 1365 3924 1570 M13446 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. 118/275 Gene Ontology BP GO:2000377 6.34802648025927e-06 1.70172557435588e-05 1725 1868.72727272727 1741 5.77094981577413e-07 835 1.74461605177101 1.8627789602611 1 9.8563308772539 1723 2775 835 1347 1626 2559 2138 2319 1741 1119 2374 1571 M15907 GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. 36/93 Gene Ontology BP GO:0045071 2.7894478610965e-06 8.99530615964832e-06 1160 1711.45454545455 1741 2.53586490720887e-07 638 1.37519438202138 -1.41081874752308 -1 8.22030583654546 1156 2013 1904 2854 1345 933 1741 638 2915 1777 1550 1572 M12194 GO_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. 67/235 Gene Ontology BP GO:0009913 1.59640019119121e-07 1.58717046845841e-06 2835 1795.81818181818 1742 1.45127300639258e-08 229 2.13033519266669 2.61524668821983 1 14.6354908481716 2831 1742 638 377 229 4509 3483 2116 322 611 2896 1573 M14330 GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of T cell mediated immunity. 39/118 Gene Ontology BP GO:0002709 0.00135680320388249 0.00199861588693732 1010 2020.27272727273 1743 0.000123421882418547 879 1.59794588277783 -1.60300373319304 -1 5.10959479423267 1006 3144 1889 3082 3889 887 1743 879 2694 1580 1430 1574 M12760 GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. 11/16 Gene Ontology BP GO:0070243 1.71854402961577e-05 3.91713300417575e-05 3430 1927.27272727273 1745 1.56232495843533e-06 273 2.00796531829216 -1.27293513638996 -1 10.4828751159189 3426 473 931 1152 1917 2197 1745 3961 273 985 4140 1575 M10163 GO_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 56/235 Gene Ontology BP GO:0007586 1.20967774194274e-07 1.35993553410173e-06 4430 2159.27272727273 1746 1.09970709859754e-08 254 2.56667115826144 -2.49911498319371 -1 17.8371723977781 4427 1746 259 254 963 3166 4562 2417 853 546 4559 1576 M14617 GO_IRON_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_IMPORT.html The directed movement of iron ions into a cell or organelle. 8/16 Gene Ontology BP GO:0097286 0.000325129834089966 0.000531916074587636 2205 2153.72727272727 1750 3.25177413121578e-05 787 2.32873339233848 -2.24136517655061 -1 9.03227759927344 2205 1511 4259 2427 2704 1687 1742 2936 787 1750 1683 1577 M11780 GO_DORSAL_VENTRAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_PATTERN_FORMATION.html The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 38/135 Gene Ontology BP GO:0009953 5.52481506100582e-08 8.29891725982205e-07 1175 1537.18181818182 1751 5.02255927249944e-09 43 1.38422752212123 1.36781801058841 1 9.97146526875771 1172 1751 1842 1107 43 1815 941 2362 1487 2313 2076 1578 M13625 GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. 61/159 Gene Ontology BP GO:0046887 9.7052197027668e-06 2.41252689848981e-05 2230 1951.63636363636 1751 8.8229659247761e-07 467 1.7926206622246 2.15248699913134 1 9.80564005772642 2230 1318 687 872 1751 3896 3414 3582 1367 467 1884 1579 M10690 GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an alpha-amino acid. 35/84 Gene Ontology BP GO:1901607 3.75281358923152e-06 1.12474942512075e-05 1500 1752.45454545455 1752 3.41165453717059e-07 1216 1.60692761618569 1.85293933174367 1 9.42078076994408 1500 1752 2290 1900 1455 2225 1216 1848 1253 1638 2200 1580 M16663 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY.html Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. 6/14 Gene Ontology BP GO:2000095 0.00706849209795271 0.00955151595191922 1295 2086.27272727273 1752 0.000709107688051049 943 1.70443891717698 1.70443891717698 1 4.0784504291939 1294 3050 4600 1752 3405 1236 943 2011 1330 2204 1124 1581 M15500 GO_POSITIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 548/1446 Gene Ontology BP GO:0051050 6.05909143068846e-07 3.23212152206309e-06 1590 1798 1754 6.05909308275558e-08 235 1.68230592990019 1.90725184637568 1 10.9419791014793 1590 865 4415 1088 780 2586 2467 2084 1914 235 1754 1582 M16412 GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. 7/15 Gene Ontology BP GO:0048711 0.000606733588399681 0.000951389412678054 1760 2025.54545454545 1756 6.06899308624923e-05 1136 1.55505577860565 -1.48007889234541 -1 5.56630379262039 1756 2075 4561 2136 2824 1136 1685 1310 1476 1520 1802 1583 M10392 GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 8/18 Gene Ontology BP GO:0009151 0.000280758576818159 0.00046456239207652 1710 2298.90909090909 1757 2.80794054547056e-05 481 0.680261265816732 -0.698317578234574 -1 2.68585860942659 1709 481 3577 2900 2677 1427 1757 1437 3373 4200 1750 1584 M12607 GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. 14/34 Gene Ontology BP GO:0002292 6.41983685554151e-07 3.33042486260103e-06 2280 1710.36363636364 1757 5.83621702629072e-08 767 1.34008532653533 -1.37389325930654 -1 8.69546646022707 2277 1347 1852 1251 767 1757 2218 1985 1548 1387 2425 1585 M15129 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 3/21 Gene Ontology BP GO:0033139 0.000817573340306948 0.00124663153334816 1375 2077.90909090909 1757 8.17874287923289e-05 772 2.31589561865601 -2.31589561865601 -1 7.96769621618504 1374 2903 4358 3108 3152 772 950 808 1757 2595 1080 1586 M16209 GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. 22/70 Gene Ontology BP GO:2000677 2.31363634437473e-05 5.05462616666116e-05 1180 1923.18181818182 1757 2.10332788741483e-06 1023 1.20519458578289 -1.15105379910908 -1 6.13381766329633 1180 1757 2550 1809 2002 1023 1702 1425 3115 2866 1726 1587 M13071 GO_RESPONSE_TO_SALT_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. 16/30 Gene Ontology BP GO:0009651 7.97718900053684e-07 3.78470495975357e-06 2070 1690.36363636364 1758 7.2519926300573e-08 834 1.97368799216088 -1.87591621505137 -1 12.6769124408824 2068 834 1162 1234 860 2195 1758 2674 2263 1149 2397 1588 M15876 GO_PLATELET_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DEGRANULATION.html The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. 62/171 Gene Ontology BP GO:0002576 1.00843568967176e-05 2.49234021692831e-05 2055 1624.81818181818 1758 9.16763920152287e-07 610 1.8017069774777 1.69326839493605 1 9.82517308945806 634 2054 610 2124 1758 1148 916 2767 2968 840 2054 1589 M15888 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 3/21 Gene Ontology BP GO:0033141 0.000788355964406236 0.00120564451341836 1375 2088.81818181818 1758 7.88635781433748e-05 773 2.31589561865601 -2.31589561865601 -1 8.0075279143256 1375 2904 4475 3109 3153 773 951 801 1758 2597 1081 1590 M12359 GO_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 276/935 Gene Ontology BP GO:0034220 7.96114892511743e-09 1.67256174024073e-07 2015 1745.54545454545 1759 7.23740813993317e-10 110 1.6493701500285 1.79269096600227 1 13.2406459216064 2014 630 199 782 658 3774 2644 4588 1759 110 2043 1591 M16764 GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that modulates the frequency, rate or extent of response to reactive oxygen species. 19/43 Gene Ontology BP GO:1901031 1.82553595122679e-06 6.65303251298742e-06 3335 2117.72727272727 1759 1.65957951458029e-07 370 2.26849842202238 -2.10112300988745 -1 13.9121114317789 3331 1759 990 934 1181 3833 2986 3523 370 1453 2935 1592 M12954 GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. 17/31 Gene Ontology BP GO:0045652 0.00131555817541715 0.0019421738023726 1235 1872 1760 0.00011966777394664 1233 1.50989848740871 -1.31004972278172 -1 4.85030723782476 1334 1760 1363 2195 2970 1233 2514 1831 2820 1235 1337 1593 M12619 GO_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYMERIZATION.html The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. 43/96 Gene Ontology BP GO:0051258 1.10298715841879e-05 2.68405103592161e-05 2230 1724.90909090909 1761 1.00272062579068e-06 519 1.69055810054565 1.58196152724385 1 9.15459683575808 2228 1084 1106 631 1784 2576 1761 3594 814 519 2877 1594 M13740 GO_NEGATIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 101/307 Gene Ontology BP GO:0051048 7.44307197933397e-07 3.61865792670656e-06 2550 2085.27272727273 1761 6.766431361351e-08 338 1.88413282242557 2.10283184356429 1 12.1451923326487 2547 525 338 1127 837 4458 3696 4035 1761 660 2954 1595 M15585 GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 18/49 Gene Ontology BP GO:0032350 9.36106895680307e-05 0.000171183312983209 2985 1718.63636363636 1761 8.51042481540984e-06 387 1.99798945361439 -1.6062044521797 -1 8.91484159157955 2985 1761 993 601 2416 2546 1031 2676 387 955 2554 1596 M11228 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. 52/151 Gene Ontology BP GO:0051153 3.51879519402001e-07 2.48294317413905e-06 3135 2293.63636363636 1762 3.19890523348605e-08 485 1.74858830181389 -1.69144167864852 -1 11.6103095329713 3133 1747 769 1657 485 4481 3558 3367 1762 796 3475 1597 M10430 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. 13/45 Gene Ontology BP GO:0045956 2.1697857005756e-06 7.59752263029601e-06 1765 1795.36363636364 1764 1.97253440051356e-07 962 1.60423549412425 1.56717120400454 1 9.72879614684606 1884 1764 1763 1870 1235 2442 1527 2993 962 1243 2066 1598 M12310 GO_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 929/2794 Gene Ontology BP GO:0009605 4.92798634955732e-10 1.33804915912249e-08 1665 1788 1766 4.92798635065014e-11 35 1.74056414785173 1.93269587352707 1 16.234445621242 1664 188 3889 1303 543 3547 2728 2213 1792 35 1766 1599 M12425 GO_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMOCYTE_AGGREGATION.html The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. 31/63 Gene Ontology BP GO:0071594 2.00246229023385e-06 7.14637387667622e-06 2285 1814.81818181818 1768 1.82042192081603e-07 513 1.35693199926347 1.55411843751633 1 8.27177368954912 2282 910 1824 513 1210 3710 2779 1493 1450 1768 2024 1600 M13558 GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 732/2007 Gene Ontology BP GO:1901700 2.96027042414596e-11 9.95980839080413e-10 1295 1581.90909090909 1768 2.96027042418539e-12 2 1.74158035499881 1.91117885782204 1 18.5715640087173 1293 2 4096 670 370 2975 2413 1880 1768 23 1911 1601 M10578 GO_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LOCALIZATION.html Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. 150/339 Gene Ontology BP GO:0051648 1.78515144201656e-06 6.54696535962314e-06 2420 1866.27272727273 1769 1.6228662641346e-07 961 1.69247218018028 2.00819747739013 1 10.3934853526481 2420 961 1769 971 1174 3562 1998 2276 1283 1337 2778 1602 M12796 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. 54/121 Gene Ontology BP GO:0009063 2.27628288462786e-06 7.8229322230401e-06 2820 1877.36363636364 1769 2.06935021803825e-07 968 1.91510336391585 -1.88388414158752 -1 11.5852307090426 2816 1390 968 1384 1259 1769 3123 2428 1784 1065 2665 1603 M13497 GO_PROTEIN_ADP_RIBOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ADP_RIBOSYLATION.html The transfer, from NAD, of ADP-ribose to protein amino acids. 12/22 Gene Ontology BP GO:0006471 2.44747565183216e-05 5.29293281280049e-05 1850 1532.09090909091 1769 2.22500261831999e-06 354 2.01578499932852 2.52215097811386 1 10.2115289244543 1850 1431 2043 1254 2017 2360 1769 802 354 2354 619 1604 M14256 GO_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_IN_THYMUS.html The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. 31/63 Gene Ontology BP GO:0033077 2.00246229023385e-06 7.14637387667622e-06 2285 1828.18181818182 1769 1.82042192081603e-07 514 1.35693199926347 1.55411843751633 1 8.27177368954912 2283 911 1825 514 1211 3711 2780 1630 1451 1769 2025 1605 M15167 GO_EMBRYONIC_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_EYE_MORPHOGENESIS.html The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. 21/53 Gene Ontology BP GO:0048048 1.04872988638485e-05 2.58042017089818e-05 4430 2495.27272727273 1769 9.53395350604886e-07 428 1.76242426486779 -1.46589228980303 -1 9.57946380583089 4430 684 1285 1446 1769 3399 4466 3248 428 1686 4607 1606 M15189 GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. 66/198 Gene Ontology BP GO:0002761 7.85683888995547e-07 3.74146697087828e-06 2205 1815.54545454545 1769 7.14258335987474e-08 857 1.64625919057121 -1.92859827829724 -1 10.5835828149136 2201 3087 1492 2173 857 1443 2692 942 2135 1180 1769 1607 M13728 GO_FEMALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_SEX_DIFFERENTIATION.html The establishment of the sex of a female organism by physical differentiation. 66/166 Gene Ontology BP GO:0046660 1.04942344786601e-05 2.5807590404883e-05 3600 2327.81818181818 1770 9.5402586705558e-07 646 1.86576834913682 1.94790725867531 1 10.1410532933258 3597 769 646 878 1770 4303 3254 3996 1432 977 3984 1608 M15428 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. 10/20 Gene Ontology BP GO:0045943 1.88850332488269e-05 4.24475095067846e-05 1115 1662.45454545455 1770 1.71683594199116e-06 376 1.47452491530083 1.47452491530083 1 7.63703805565947 1114 2168 2842 2448 1949 876 571 376 1770 3591 582 1609 M10999 GO_PEROXISOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 25/36 Gene Ontology BP GO:0007031 1.05831962586189e-05 2.59988255178665e-05 565 2012.36363636364 1771 9.62113379080952e-07 258 0.829521254895171 -0.829863474996628 -1 4.5055641838417 561 2465 3244 3995 1771 258 509 990 3515 3982 846 1610 M11799 GO_LIPID_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. 8/42 Gene Ontology BP GO:0044241 3.34952880037052e-08 5.73869454616986e-07 4490 2064.54545454545 1771 3.34952885085755e-09 26 3.09288378797105 -3.73324348971238 -1 22.8669825036764 4490 1358 3806 476 26 3441 2076 1771 222 1052 3992 1611 M10525 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 69/187 Gene Ontology BP GO:0014066 2.23898456159362e-06 7.74058475017066e-06 1330 1820.45454545455 1772 2.03544258205165e-07 937 1.63755499354331 1.81772330482498 1 9.91514399104437 1329 2617 937 1772 1252 2231 2193 1650 2418 1590 2036 1612 M13317 GO_GLYCOPROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 7/29 Gene Ontology BP GO:0006516 3.99120930549248e-05 8.03955956850394e-05 575 1585 1772 3.99128099118728e-06 283 1.27504020476433 -1.27504020476433 -1 6.18487798316684 571 1772 4052 2122 2742 283 368 348 2326 2385 466 1613 M10594 GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 147/347 Gene Ontology BP GO:0033673 3.28002053686219e-07 2.36477257028745e-06 2320 1791.72727272727 1773 2.98183729626054e-08 465 1.55414191090275 1.83006664291747 1 10.3582094785581 2317 1674 1219 1735 465 2869 1782 1773 1797 1440 2638 1614 M15370 GO_NEURAL_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_FORMATION.html The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. 64/142 Gene Ontology BP GO:0001841 2.70657807705256e-07 2.10849698183809e-06 405 1768.54545454545 1773 2.46052582730259e-08 401 1.30821355319912 1.21674294280195 1 8.79632195614009 1753 401 2070 613 404 2554 1854 4397 1773 1082 2553 1615 M16159 GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. 29/67 Gene Ontology BP GO:0035306 1.07824228360836e-05 2.63719552509003e-05 1760 2128.63636363636 1776 9.80225062017512e-07 944 1.69608328178212 2.00552787810703 1 9.19988375090417 944 3398 1759 2558 1776 2293 1460 1757 2846 2894 1730 1616 M16271 GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 11/27 Gene Ontology BP GO:0042454 1.18304164152007e-05 2.85937654428822e-05 1680 1766.45454545455 1779 1.07549818484495e-06 475 1.27939373877687 1.51327270143228 1 6.88643740257233 1680 475 1837 1949 1798 1779 1589 1575 2107 2948 1694 1617 M13129 GO_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction. 11/38 Gene Ontology BP GO:0019098 7.60160201917437e-06 1.97284729877175e-05 3750 2319.63636363636 1781 6.91057116810595e-07 587 2.69493223732329 -2.88807105823268 -1 15.0202410484249 3749 1716 1272 1781 1678 4580 3316 2365 587 1539 2933 1618 M15655 GO_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_LOCALIZATION.html Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. 31/54 Gene Ontology BP GO:0051646 1.08479755836348e-05 2.64394491521346e-05 1130 1830.36363636364 1781 9.86184461296828e-07 408 1.31715559416647 1.54914700406615 1 7.142774236759 1126 2690 2400 3255 1781 796 873 1694 2947 2164 408 1619 M15744 GO_NEUROMUSCULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS.html Any process pertaining to the functions of the nervous and muscular systems of an organism. 41/199 Gene Ontology BP GO:0050905 1.09696874585549e-06 4.68558039283075e-06 985 1521.27272727273 1781 9.97244811662537e-08 503 1.96519776619966 2.4413804074613 1 12.4065007742971 1868 981 728 503 981 2136 1959 2793 1051 1781 1953 1620 M16157 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. 21/60 Gene Ontology BP GO:0040018 8.86536109115935e-05 0.000162823858964608 2020 2013.45454545455 1781 8.05974396329177e-06 694 1.59647950681381 -1.79073069585157 -1 7.16446298566112 2020 1694 2495 1636 2402 1781 3430 694 1479 3260 1257 1621 M12756 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. 7/28 Gene Ontology BP GO:0032693 7.32983535973452e-06 1.90978819165249e-05 3300 2301 1782 7.32985953676564e-07 649 2.67408104886919 -2.21754080763949 -1 14.9487183035573 3299 1947 3955 1782 1693 1572 1265 3937 649 919 4293 1622 M13785 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK.html The synchronization of a circadian rhythm to environmental time cues such as light. 17/73 Gene Ontology BP GO:0009649 4.38134249649799e-06 1.26587263293343e-05 2785 2027.72727272727 1782 3.98304656550048e-07 529 2.2289902400456 -1.57880786023442 -1 12.9321403740226 2785 1103 1140 1759 1512 1782 3426 4254 529 1797 2218 1623 M13435 GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response. 10/29 Gene Ontology BP GO:0002739 0.000214163504752867 0.000363835035699802 1785 2032 1783 1.94713050708652e-05 564 2.18464393631487 -2.18464393631487 -1 8.90026457549817 1783 2930 2328 2349 3824 1283 1560 564 1637 2826 1268 1624 M11554 GO_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_ENGULFMENT.html The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. 18/159 Gene Ontology BP GO:0006911 7.77081331597457e-05 0.000144782850024358 2220 1604.18181818182 1784 7.06462528115814e-06 400 2.17839386281493 2.39154629547468 1 9.90751058236765 2216 1337 1036 871 2372 1836 2111 1784 400 689 2994 1625 M16589 GO_ZYMOGEN_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_ACTIVATION.html The proteolytic processing of an inactive enzyme to an active form. 75/192 Gene Ontology BP GO:0031638 1.69228837898209e-06 6.33142219469287e-06 2185 1984.81818181818 1784 1.53844516429903e-07 593 1.76812336953354 2.01117812322655 1 10.8885121671927 2182 1784 873 1260 1148 4233 3823 2139 1382 593 2416 1626 M11196 GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. 31/50 Gene Ontology BP GO:0046825 0.00152019814993478 0.00222308031815659 725 2212.27272727273 1789 0.000138295420264764 724 1.52068121375823 1.68716444596585 1 4.77926069676703 724 3938 2479 3968 3272 1090 774 896 1789 3772 1633 1627 M14320 GO_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 13/38 Gene Ontology BP GO:0070741 0.00193274116537096 0.00278600348674864 2105 1983.72727272727 1790 0.000175858291449225 1490 2.64353161481331 -3.12604653490012 -1 8.00122607552332 2103 1708 1665 2166 3047 1538 2187 1644 1490 2483 1790 1628 M12131 GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. 10/20 Gene Ontology BP GO:2000647 9.26050210273436e-06 2.31662237408382e-05 3070 1920.72727272727 1791 8.41867371215709e-07 1078 1.51603035237216 -1.18503703094739 -1 8.32432852929672 3069 1435 2184 1097 1737 1791 1383 2102 1078 2061 3191 1629 M16438 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 7/17 Gene Ontology BP GO:0032230 1.04293989003603e-05 2.56889650368027e-05 4095 2334.09090909091 1791 1.04294478482463e-06 315 2.3125101313555 -3.24461187885586 -1 12.5747207086845 4093 721 4565 1747 1791 3497 1583 315 407 2409 4547 1630 M11744 GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. 17/82 Gene Ontology BP GO:0021515 0.00738671150739614 0.00995544311432229 1295 1948.63636363636 1792 0.000673784574055601 949 2.11289482132107 2.29850820743235 1 5.01079646757776 1295 2857 1367 2366 3714 1416 949 2507 2057 1792 1115 1631 M12468 GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 8/24 Gene Ontology BP GO:0010758 0.000578091434194065 0.000909240694093172 1365 1990.54545454545 1792 5.7824187464476e-05 1045 1.86336669532632 1.86336669532632 1 6.7133393665464 1361 1443 3913 1849 2814 2202 1692 1045 2044 1741 1792 1632 M15820 GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION.html Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. 7/29 Gene Ontology BP GO:0007263 0.00199874274633827 0.0028748954681687 1105 2057.36363636364 1792 0.000200054276299872 873 2.77634447758689 2.77634447758689 1 8.35835130918661 1102 2736 4462 1792 3075 1327 899 1363 2598 2404 873 1633 M12908 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. 21/56 Gene Ontology BP GO:1901021 2.47880819167324e-05 5.34809778528757e-05 2275 1954.72727272727 1798 2.25348738328549e-06 1048 2.02121778739917 1.93744713574365 1 10.2282685065014 2274 1798 1243 1784 2021 3042 2712 1686 1048 1220 2674 1634 M11339 GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/33 Gene Ontology BP GO:0032373 5.33202253803679e-05 0.000103670773216519 1815 1900 1799 4.84741070164113e-06 1003 2.45026200116736 2.45026200116736 1 11.5650457243565 1814 1710 1799 1191 2265 2719 3409 1003 1365 2472 1153 1635 M15839 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/33 Gene Ontology BP GO:0032376 5.33202253803679e-05 0.000103670773216519 1815 1901.81818181818 1800 4.84741070164113e-06 998 2.45026200116736 2.45026200116736 1 11.5650457243565 1815 1711 1800 1192 2266 2720 3410 998 1366 2488 1154 1636 M10471 GO_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 26/70 Gene Ontology BP GO:0051602 0.00971653656525849 0.012915510813769 1120 1863 1801 0.000887247084735319 844 1.79774968566077 1.92487016296945 1 4.02266108359446 1116 2547 844 2179 3671 1801 1572 2258 2196 960 1349 1637 M11612 GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 23/61 Gene Ontology BP GO:0010591 1.20782144057551e-05 2.90716171518511e-05 660 1579.36363636364 1803 1.09802551971263e-06 158 1.52120886873678 1.49244510448095 1 8.17505580057129 658 2695 2336 2384 1803 568 158 1016 1982 2896 877 1638 M12742 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. 38/101 Gene Ontology BP GO:0032088 4.10926575852046e-05 8.24160730747754e-05 1055 1814.63636363636 1805 3.73576592306263e-06 366 1.13568048208189 -0.809438046274814 -1 5.49437878834211 1051 1324 2725 2592 2191 366 591 2314 1805 3728 1274 1639 M16214 GO_RUFFLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. 17/42 Gene Ontology BP GO:0031529 1.62517900927536e-05 3.73364974768209e-05 2035 1795.09090909091 1805 1.47744637716821e-06 1226 1.87950728993271 -1.05410301539357 -1 9.85862967396241 2031 2317 1618 1226 1901 2242 1762 1430 1373 1805 2041 1640 M10829 GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an alpha-amino acid. 114/255 Gene Ontology BP GO:1901605 2.18132426970264e-06 7.62068366006725e-06 3730 2054.27272727273 1806 1.98302402955702e-07 756 1.65751355003952 -1.69395741398797 -1 10.0493023449446 3730 756 853 1469 1239 2570 4242 1953 1806 872 3107 1641 M11877 GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 31/72 Gene Ontology BP GO:0009064 1.21984030756235e-05 2.93153133955071e-05 4250 2534.45454545455 1806 1.10895188299852e-06 980 1.73911446965832 -1.53377378539288 -1 9.33862321199194 4247 989 980 993 1806 4116 4544 3552 1151 1002 4499 1642 M13375 GO_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that modulates the frequency, rate, or extent of cellular extravasation. 13/37 Gene Ontology BP GO:0002691 0.000222114663854988 0.000375967329303212 555 1746.36363636364 1806 2.01942810900529e-05 555 1.76700534555231 1.97041537345708 1 7.16898059306967 555 1806 737 1867 2613 1102 1052 1911 3836 2478 1253 1643 M16254 GO_AXIS_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_ELONGATION.html The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. 17/43 Gene Ontology BP GO:0003401 1.05705419491841e-06 4.5767422418135e-06 3680 2243.81818181818 1806 9.60958820737532e-08 813 1.57136101465118 -2.09241912330046 -1 9.9391673113814 3676 1416 1780 813 965 3819 4569 930 1847 1806 3061 1644 M13144 GO_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. 27/94 Gene Ontology BP GO:0042632 4.42415203168695e-06 1.2703362945654e-05 1270 1984 1807 4.02196448053207e-07 1269 1.75759986276086 2.02229397824839 1 10.1940476705981 1269 3281 1320 1295 1520 2669 2580 1807 2803 1827 1453 1645 M11301 GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0033865 2.7115617060235e-05 5.75664426203342e-05 2190 1703 1808 2.46508647941706e-06 525 1.45561121021458 -1.3377550867096 -1 7.31091776813184 2190 1808 2409 1622 2056 747 1351 2708 525 1839 1478 1646 M13509 GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 578/1576 Gene Ontology BP GO:0044092 1.87736226443449e-07 1.73637310632855e-06 1810 1770 1808 1.87736242303651e-08 311 1.59417896789416 1.8043818267781 1 10.8783870206098 1808 952 4089 1126 311 2912 2174 1988 2043 501 1566 1647 M12620 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0034032 2.7115617060235e-05 5.75664426203342e-05 2195 1708.90909090909 1809 2.46508647941706e-06 526 1.45561121021458 -1.3377550867096 -1 7.31091776813184 2191 1809 2410 1623 2057 748 1352 2760 526 1843 1479 1648 M15439 GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 6/19 Gene Ontology BP GO:0050746 5.57546344672968e-07 3.09534389000729e-06 1755 2011.09090909091 1809 5.57546484559082e-08 747 2.19033919574625 2.19033919574625 1 14.2950324386931 1754 2244 4405 2507 747 2399 1809 1246 1300 2199 1512 1649 M15905 GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. 27/77 Gene Ontology BP GO:1902930 1.23255490909739e-05 2.95797853035767e-05 2665 1739.54545454545 1809 1.1205107405163e-06 598 2.15088455619814 -1.65578141524776 -1 11.5397908621941 2662 1755 772 1048 1809 1343 2028 3436 598 1829 1855 1650 M13130 GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0033875 2.7115617060235e-05 5.75664426203342e-05 2195 1708.45454545455 1810 2.46508647941706e-06 527 1.45561121021458 -1.3377550867096 -1 7.31091776813184 2192 1810 2411 1624 2058 749 1353 2743 527 1846 1480 1651 M15772 GO_NEPHRON_TUBULE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_TUBULE_FORMATION.html The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. 9/25 Gene Ontology BP GO:0072079 4.19297729152291e-07 2.64870660742053e-06 1810 1667.54545454545 1810 4.19297808267075e-08 104 1.87608170711304 2.63900274209669 1 12.3944654072085 1810 604 4455 435 620 3044 1935 1888 104 1926 1522 1652 M15998 GO_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BINDING.html Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 205/486 Gene Ontology BP GO:0051098 3.18208092073562e-06 9.90905547617404e-06 980 2062.81818181818 1810 2.8928050211892e-07 979 1.54470920199563 1.74820198711136 1 9.15670571623501 979 3104 2234 2606 1396 1810 1492 1637 2630 3453 1350 1653 M10130 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 22/102 Gene Ontology BP GO:0018958 9.06103649676279e-06 2.2753051624916e-05 3580 2601.72727272727 1811 8.23733983294791e-07 836 2.28829632747787 -1.90500415218374 -1 12.5859291286132 4355 1692 836 1526 1729 4237 4110 3579 1167 1811 3577 1654 M11769 GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. 177/373 Gene Ontology BP GO:0006520 1.55748465518909e-06 6.01584882645259e-06 3425 2157.45454545455 1811 1.41589614346151e-07 959 1.5485725224233 -1.39696442508471 -1 9.57720026505047 3421 959 1334 1811 1103 2296 3656 2664 1709 1556 3223 1655 M11391 GO_POSITIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BEHAVIOR.html Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 9/31 Gene Ontology BP GO:0048520 0.00587803575237384 0.00800813380230978 1135 2015.18181818182 1812 0.000589364196884898 545 1.70980447551915 2.10031853034268 1 4.24632037632879 1131 2932 3735 2774 3244 1059 545 1263 1812 1909 1763 1656 M11430 GO_RESPONSE_TO_AXON_INJURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AXON_INJURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. 36/74 Gene Ontology BP GO:0048678 8.97023557193008e-05 0.000164554736311621 1815 1760.90909090909 1813 8.15509213034855e-06 490 2.28098844660858 2.43454252660443 1 10.2239006012139 1813 2139 928 658 2405 2552 2485 3580 490 1359 961 1657 M11702 GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND.html A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. 22/47 Gene Ontology BP GO:0001702 1.10849091789457e-07 1.29465148368895e-06 1820 1793.45454545455 1813 1.00771906704268e-08 136 1.87382692039677 1.96715599477037 1 13.0696526361889 1817 1974 1232 1497 136 3061 2845 2146 1482 1813 1725 1658 M16375 GO_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_MATURATION.html Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 12/23 Gene Ontology BP GO:0090128 3.75723962602257e-06 1.12474942512075e-05 1100 1509.27272727273 1813 3.41567822071612e-07 124 1.55037784546236 1.76267623628828 1 9.08925178113915 1098 1813 1924 2244 2821 584 430 124 2148 2365 1051 1659 M12840 GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to another neuron across a synapse. 22/105 Gene Ontology BP GO:0007270 4.10392075228054e-06 1.20445664050813e-05 1590 1981.72727272727 1814 3.73084400711848e-07 621 1.25740870343263 1.1681092973777 1 7.327397021845 1587 1555 2315 2137 1490 1795 621 4305 2233 1814 1947 1660 M11340 GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. 12/29 Gene Ontology BP GO:0095500 2.22696171079901e-06 7.71689992869878e-06 3025 2052.72727272727 1815 2.0245126955055e-07 1164 1.50696837145737 1.68677822221464 1 9.12683781573572 3021 1274 1389 1815 1243 3214 2331 1164 1957 1644 3528 1661 M15794 GO_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. 19/61 Gene Ontology BP GO:0030850 9.56071891684339e-05 0.000174148363793267 2510 1904.54545454545 1815 8.69194039096466e-06 368 2.46319308102547 -2.05168525924803 -1 10.9687750242284 2510 3250 1396 1857 2425 1588 2961 1328 368 1452 1815 1662 M10989 GO_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 428/1046 Gene Ontology BP GO:0043549 2.79732704494019e-07 2.15487069452492e-06 1820 1539.09090909091 1816 2.54302490965802e-08 411 1.53809866186769 1.69514914042511 1 10.3248358706017 1816 955 477 924 411 3293 2622 1884 2019 536 1993 1663 M11878 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION.html Any signal transduction that is involved in cellular response to ammonium ion. 12/29 Gene Ontology BP GO:1903831 2.22696171079901e-06 7.71689992869878e-06 3025 2056.63636363636 1816 2.0245126955055e-07 1195 1.50696837145737 1.68677822221464 1 9.12683781573572 3022 1275 1390 1816 1244 3215 2332 1195 1958 1647 3529 1664 M12189 GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 12/29 Gene Ontology BP GO:1905145 2.22696171079901e-06 7.71689992869878e-06 3025 2056.72727272727 1817 2.0245126955055e-07 1183 1.50696837145737 1.68677822221464 1 9.12683781573572 3023 1276 1391 1817 1245 3216 2333 1183 1959 1651 3530 1665 M15627 GO_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 14/45 Gene Ontology BP GO:0050704 0.000136241858412917 0.00023988280190033 2435 1814.45454545455 1817 1.23863905769363e-05 477 1.44201736497243 1.50852735475667 1 6.18382443124852 2431 1349 1592 1922 2503 1733 477 2037 3162 936 1817 1666 M13242 GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. 12/29 Gene Ontology BP GO:0007213 2.22696171079901e-06 7.71689992869878e-06 3025 2059.72727272727 1818 2.0245126955055e-07 1204 1.50696837145737 1.68677822221464 1 9.12683781573572 3024 1277 1392 1818 1246 3217 2334 1204 1960 1654 3531 1667 M13299 GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. 10/26 Gene Ontology BP GO:0006688 0.00542899930697079 0.00744443112293721 860 1931.45454545455 1819 0.000494767551239269 616 1.50752728165344 1.50075281010946 1 3.800573161792 856 2321 1819 2419 3223 1211 616 2464 3672 1370 1275 1668 M14251 GO_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 12/29 Gene Ontology BP GO:1905144 2.22696171079901e-06 7.71689992869878e-06 3025 2056.09090909091 1819 2.0245126955055e-07 1153 1.50696837145737 1.68677822221464 1 9.12683781573572 3025 1278 1393 1819 1247 3218 2335 1153 1961 1656 3532 1669 M11496 GO_XENOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XENOPHAGY.html The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. 66/157 Gene Ontology BP GO:0098792 3.33082135138627e-06 1.02689266497254e-05 2945 1994.45454545455 1820 3.02802399481164e-07 1004 1.88275457891456 -1.75984413000751 -1 11.1260125139473 2941 1743 1384 2566 1409 1455 3310 1967 1004 2340 1820 1670 M15706 GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION.html Signal transduction in which the initial step occurs in a postsynapse. 12/29 Gene Ontology BP GO:0098926 2.22696171079901e-06 7.71689992869878e-06 3030 2062.09090909091 1820 2.0245126955055e-07 1202 1.50696837145737 1.68677822221464 1 9.12683781573572 3026 1279 1394 1820 1248 3219 2336 1202 1962 1664 3533 1671 M16880 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin depolymerization. 9/21 Gene Ontology BP GO:0030836 1.14861743932195e-05 2.78341898265753e-05 3185 2216.18181818182 1820 1.14862337631424e-06 591 1.74241052539279 -2.54325138476412 -1 9.40279719200544 3185 1286 4629 1044 1820 2513 1555 1175 591 1939 4641 1672 M12216 GO_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_DEVELOPMENT.html The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 45/114 Gene Ontology BP GO:0001892 1.92330866455854e-07 1.75506689760962e-06 3375 2088.18181818182 1821 1.74846257518201e-08 294 1.68900589720623 -2.15608967765275 -1 11.5161637319061 3373 1542 1128 1534 294 2568 4367 1709 1821 2048 2586 1673 M13929 GO_PURINE_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOTIDE_TRANSPORT.html The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. 9/18 Gene Ontology BP GO:0015865 0.00011514590556211 0.000205940847274606 1505 1906.63636363636 1821 1.15151872358053e-05 846 1.14751598953214 1.52815651111883 1 5.01097656162662 1502 1290 4159 1959 2488 1586 846 2072 1333 1917 1821 1674 M15717 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. 58/166 Gene Ontology BP GO:0045638 5.39290990042622e-06 1.49043337307613e-05 1325 2090.81818181818 1821 4.90265738203086e-07 599 1.42227829391174 -1.33253186326539 -1 8.1322696332374 1324 3029 1821 3219 1581 599 1729 2369 3133 2881 1314 1675 M15985 GO_RESPONSE_TO_FOLIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. 9/23 Gene Ontology BP GO:0051593 0.000648018092099666 0.00100735985713395 1825 2230.54545454545 1822 6.48207137041946e-05 769 2.59335563849091 -2.59335563849091 -1 9.20661719523996 1822 3669 4491 3445 4173 1485 811 769 857 1930 1084 1676 M15552 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 52/127 Gene Ontology BP GO:0051279 8.03464920996966e-07 3.79688087709529e-06 1825 1852 1825 7.3042292221055e-08 863 1.54125421009372 -1.24244257997075 -1 9.89686174914276 1825 2340 1553 1764 863 2273 1349 1931 2926 2161 1387 1677 M10645 GO_STEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. 27/94 Gene Ontology BP GO:0055092 4.42415203168695e-06 1.2703362945654e-05 1270 1986.54545454545 1826 4.02196448053207e-07 1268 1.75759986276086 2.02229397824839 1 10.1940476705981 1268 3280 1319 1294 1519 2668 2579 1845 2802 1826 1452 1678 M12185 GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. 11/33 Gene Ontology BP GO:1903409 1.38479704052443e-06 5.56194866708904e-06 3020 1957.36363636364 1826 1.25890719290011e-07 454 1.70128744781647 -1.55962437558106 -1 10.590334853467 3017 1576 1714 454 1064 1826 2625 3529 1605 2231 1890 1679 M14895 GO_CELL_MIGRATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_IN_HINDBRAIN.html The orderly movement of a cell that will reside in the hindbrain. 5/24 Gene Ontology BP GO:0021535 0.000404334376042393 0.000650043112176188 1000 2288.18181818182 1826 4.0440796371675e-05 327 0.943553575040996 0.943553575040996 1 3.56233211619194 999 1826 4311 2864 2753 679 327 1711 3852 4504 1344 1680 M10210 GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 10/40 Gene Ontology BP GO:0045745 9.49497355869826e-06 2.36381566933169e-05 1650 1969.81818181818 1827 8.63183139843132e-07 737 1.27539496804894 1.48432332297138 1 6.98979756812827 1650 2072 1875 2281 1746 1715 737 1827 3707 2804 1254 1681 M12662 GO_NEURAL_NUCLEUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_NUCLEUS_DEVELOPMENT.html The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. 55/153 Gene Ontology BP GO:0048857 5.84917501173468e-06 1.59376288611996e-05 1725 1746 1828 5.31744596644296e-07 1012 2.10707656693717 2.43908789797354 1 11.9751302979813 1725 1892 1182 1441 1599 2314 2134 1828 1012 2045 2034 1682 M15962 GO_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_MEDIATED_ENDOCYTOSIS.html An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. 27/51 Gene Ontology BP GO:0072583 1.12960221160256e-06 4.79631774385374e-06 1905 1735.54545454545 1830 1.02691162873045e-07 117 1.73566127991666 2.32661921088835 1 10.9365543708847 1901 2016 1919 1166 989 3031 3024 1449 117 1830 1649 1683 M10463 GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. 9/22 Gene Ontology BP GO:0033599 3.83127073117827e-06 1.13665111852145e-05 570 1674.45454545455 1831 3.83127733658024e-07 124 0.958780761580986 -0.958780761580986 -1 5.6157594005367 567 2207 3590 2369 1831 261 257 134 3601 3478 124 1684 M14216 GO_DETECTION_OF_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_VISIBLE_LIGHT.html The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 15/83 Gene Ontology BP GO:0009584 2.88619559621775e-05 6.06636765651381e-05 2590 1930.63636363636 1831 2.62384860101622e-06 714 2.16514963742975 2.21233333088905 1 10.8162543606389 2589 1423 714 755 2083 3726 1831 2910 760 1020 3426 1685 M10364 GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. 32/86 Gene Ontology BP GO:0048641 1.88531023955997e-07 1.74025754319621e-06 1955 1586.63636363636 1832 1.71391854647581e-08 286 1.57125257633387 1.84397511044863 1 10.7201350988901 1954 2261 1498 1892 286 2380 1784 723 2452 1832 391 1686 M12295 GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. 49/122 Gene Ontology BP GO:0032091 4.30483135356931e-06 1.24920824841389e-05 680 1615.90909090909 1833 3.91349070639513e-07 136 1.66251405853789 1.97800319859117 1 9.6568967749587 677 3109 1833 2054 2849 988 746 136 2353 2665 365 1687 M14575 GO_PEROXISOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOMAL_TRANSPORT.html Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 13/21 Gene Ontology BP GO:0043574 0.000249568126964555 0.000417565698557271 1340 2318.54545454545 1833 2.26905856803948e-05 655 0.616958811455866 -0.511533139989859 -1 2.46977583048205 1337 1766 3221 3685 2636 655 804 1833 3518 4487 1562 1688 M12119 GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 83/217 Gene Ontology BP GO:0046890 4.80918781053917e-07 2.85537838930094e-06 1835 2301.54545454545 1835 4.37198987438662e-08 635 1.79295394720669 2.01741939402975 1 11.7759713929412 4239 1835 1023 1149 635 2465 4510 3067 1613 1831 2950 1689 M12303 GO_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. 173/465 Gene Ontology BP GO:0019216 2.23107255946157e-06 7.7247351928263e-06 3810 2302.27272727273 1836 2.02824983822615e-07 460 1.69970096705382 1.93854875797967 1 10.2932207321504 3806 1309 819 460 1250 3378 4237 2518 1836 1099 4613 1690 M16492 GO_ISOPRENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 46/195 Gene Ontology BP GO:0006720 9.4873214519814e-05 0.000173015056958168 2345 2077.72727272727 1836 8.62520964520175e-06 684 1.59380291504085 1.86179257478759 1 7.10267137227772 2343 1681 1463 1984 2422 3609 3373 684 1675 1785 1836 1691 M10530 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 50/150 Gene Ontology BP GO:0071347 1.55954341972469e-06 6.01584882645259e-06 1535 2025.27272727273 1837 1.41776775023654e-07 1105 1.46699740611488 1.69678912298653 1 9.07269605139207 1535 1837 1223 2411 1105 2870 3086 1540 3083 1353 2235 1692 M11653 GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. 28/52 Gene Ontology BP GO:0008154 0.000151421640791335 0.00026380888487586 3270 2184.36363636364 1838 1.37665512588369e-05 1101 1.74040190359036 1.32696688817522 1 7.3782629673099 3268 1326 1158 1676 2529 3157 1838 2318 1162 1101 4495 1693 M15261 GO_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. 151/410 Gene Ontology BP GO:0050727 2.47936709028382e-07 2.00203502611962e-06 1840 1685 1838 2.2539703360953e-08 380 1.66143108049564 1.85523810943149 1 11.2156146365126 1838 518 578 830 380 3432 2640 2732 2152 706 2729 1694 M11236 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. 2/18 Gene Ontology BP GO:0045955 0.007548701794016 0.0101694793780506 1140 2127 1840 0.000841572061916693 871 0.984560600288294 -0.984560600288294 -1 2.3241408258178 1136 2046 3713 NA 3287 871 1015 1519 3762 2287 1634 1695 M11614 GO_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_KETONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 39/102 Gene Ontology BP GO:0042180 3.09058417402026e-06 9.69566372971356e-06 1110 1870.09090909091 1841 2.80962592337764e-07 920 1.48138502715114 -1.23705377203553 -1 8.7979253228384 1107 2012 2403 2389 1386 920 1841 1923 1734 3187 1669 1696 M10464 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. 31/88 Gene Ontology BP GO:0043551 0.0003539235054465 0.000574395348017429 645 2049.09090909091 1843 3.21800414069939e-05 636 1.53555953379833 1.5129549737307 1 5.89515738553173 641 3573 1823 2563 2702 1206 636 1313 3206 3034 1843 1697 M16416 GO_LEUKOTRIENE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_METABOLIC_PROCESS.html The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 19/54 Gene Ontology BP GO:0006691 6.82955901575388e-07 3.44791802398201e-06 2900 2210.36363636364 1844 6.20869194171413e-08 141 1.6359588529487 1.29915954657881 1 10.5861326720474 2896 141 1071 1514 797 3888 3091 4238 1844 1044 3790 1698 M13122 GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 13/35 Gene Ontology BP GO:0040036 1.02994301383969e-06 4.49016470728422e-06 4345 2007.81818181818 1845 9.36312269103567e-08 630 1.08768263026728 -1.41151597885389 -1 6.89049288433118 4341 1270 2074 1101 954 4094 2025 630 1027 1845 2725 1699 M11897 GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of astrocyte differentiation. 20/50 Gene Ontology BP GO:0048710 1.63834504706419e-05 3.76203563477697e-05 1965 1918.18181818182 1847 1.48941567998595e-06 418 1.90874262221398 2.28164364585175 1 10.0045409648804 1961 1847 1190 1110 1903 3162 3252 3650 418 828 1779 1700 M13131 GO_ESTABLISHMENT_OF_TISSUE_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_TISSUE_POLARITY.html Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 13/29 Gene Ontology BP GO:0007164 5.1549692613847e-07 2.94248631107142e-06 3545 2002.27272727273 1847 4.68633679025539e-08 123 1.95752530206769 -1.01318992198418 -1 12.8265987239061 3543 157 1453 977 671 4173 3580 2342 123 1847 3159 1701 M14157 GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 334/883 Gene Ontology BP GO:0071345 1.70112352807332e-06 6.34912905212573e-06 2575 2220.18181818182 1849 1.54647713040731e-07 675 1.68958030472391 1.93774125952153 1 10.4023981675391 2575 1455 675 1667 1151 4331 4254 1849 2381 1077 3007 1702 M14458 GO_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DIFFERENTIATION.html The establishment of the sex of an organism by physical differentiation. 164/438 Gene Ontology BP GO:0007548 2.16776896754823e-07 1.8925604239228e-06 1935 1853 1849 1.97069925559025e-08 330 1.70651622600939 1.62774379395587 1 11.5693359107762 1935 749 698 1456 330 2616 2247 4551 1849 893 3059 1703 M15100 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 13/49 Gene Ontology BP GO:0032228 4.87670703197904e-06 1.3747753946253e-05 2540 2002.63636363636 1850 4.43337985648726e-07 444 2.31068197478752 1.99937200676474 1 13.3079903215297 2536 1109 1757 1490 1551 2819 1909 3936 444 1850 2628 1704 M10776 GO_GLUCOCORTICOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. 4/24 Gene Ontology BP GO:0008211 0.000129672128912018 0.00022970915472663 2775 1896.54545454545 1852 1.29679696220953e-05 18 3.32806253801357 3.32806253801357 1 14.3459827677687 1432 2771 3631 1444 3398 1852 759 2377 18 2771 409 1705 M10946 GO_PEPTIDYL_SERINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_SERINE_MODIFICATION.html The modification of peptidyl-serine. 92/216 Gene Ontology BP GO:0018209 1.70441060118814e-06 6.35628788860764e-06 1305 1805 1852 1.54946538331923e-07 942 1.29110114114998 1.3491219487966 1 7.94829505542109 1301 2088 2549 1852 1152 942 1245 2777 2647 2278 1024 1706 M13975 GO_MUSCLE_ATROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ATROPHY.html A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. 5/18 Gene Ontology BP GO:0014889 2.33363821731661e-05 5.08928240629452e-05 1855 1897.09090909091 1852 2.3336627240818e-06 285 1.79487580986906 -1.79487580986906 -1 9.12868156139832 1852 1997 4168 1963 2411 1719 1536 285 1592 1979 1366 1707 M16140 GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 48/144 Gene Ontology BP GO:0002285 1.23739439648397e-07 1.37775112299163e-06 3075 1837.90909090909 1854 1.12490406007407e-08 160 1.37819999114209 -1.17108121303976 -1 9.56862060429054 3074 782 1854 1151 160 1035 2098 3889 1537 1895 2742 1708 M14490 GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 14/45 Gene Ontology BP GO:0035412 1.583898061983e-05 3.64964699840549e-05 1040 1545.27272727273 1855 1.43991769584552e-06 300 1.65848995541054 1.44843216608081 1 8.71873769281353 1037 2404 1959 1855 1891 1005 429 1571 2540 2007 300 1709 M11135 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 43/148 Gene Ontology BP GO:0003073 3.48776162360542e-05 7.12749877570421e-05 940 1828.63636363636 1857 3.17074265266253e-06 818 1.98383565623498 2.23728788627251 1 9.74595351465806 939 3031 1073 3064 2149 1370 818 1857 2534 1940 1340 1710 M11586 GO_ACETYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. 13/26 Gene Ontology BP GO:0006084 0.000221169257211628 0.000374503596365277 630 1800.27272727273 1858 2.01083177103983e-05 394 1.17500769149193 -1.17500769149193 -1 4.76952326852211 626 1858 2370 3289 2771 394 404 568 3680 3168 675 1711 M16489 GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. 10/25 Gene Ontology BP GO:0072525 0.000897597179714752 0.00135972062166904 1505 2040 1859 8.16330552303093e-05 1203 1.16819934777807 -1.28454937817356 -1 3.96692917052615 1504 1203 2381 2420 2904 1297 1282 3698 1859 2091 1801 1712 M16838 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 17/39 Gene Ontology BP GO:0045922 1.52185865875623e-06 5.92553621667409e-06 1860 1997.54545454545 1859 1.38350882864451e-07 383 1.97178568967161 2.24991005917858 1 12.2099217263192 1859 2434 2051 722 1095 3941 3489 1483 383 2911 1605 1713 M11558 GO_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE.html A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. 23/66 Gene Ontology BP GO:0090398 4.5617780599969e-05 9.049887167561e-05 2485 1890.63636363636 1861 4.14715695711778e-06 306 2.57586229299194 3.06829804542173 1 12.3379428619428 2482 1483 1861 1856 2414 3168 2153 355 306 3413 1306 1714 M11271 GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 46/224 Gene Ontology BP GO:0038094 8.32425513860526e-06 2.12593600707064e-05 1865 2155.09090909091 1862 7.56753330517449e-07 419 2.37872323688813 3.07084621059726 1 13.1663867062878 1862 3937 1664 2554 1701 2572 1773 1567 419 2878 2779 1715 M11084 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. 9/25 Gene Ontology BP GO:0034143 0.000291156865711197 0.000480398481697614 1515 2191.81818181818 1865 2.91195020291267e-05 1511 1.27603040444704 -1.37794258387976 -1 5.01611518399754 1511 1865 3686 2400 2686 1570 2445 1750 1772 2672 1753 1716 M11623 GO_CELL_PROLIFERATION_IN_FOREBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION_IN_FOREBRAIN.html The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. 11/46 Gene Ontology BP GO:0021846 0.000108914508353805 0.000195927959041734 860 2016.81818181818 1865 9.90180915581558e-06 858 1.85671284418903 -1.85671284418903 -1 8.15551116772891 858 3528 1865 3057 2455 1039 1437 991 3018 2921 1016 1717 M15169 GO_BLASTOCYST_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_GROWTH.html An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. 7/17 Gene Ontology BP GO:0001832 2.90824479317372e-05 6.10718253039602e-05 790 2000.36363636364 1871 2.90828285436977e-06 53 0.653397255002472 -0.653397255002472 -1 3.26186596411868 787 1871 4366 2818 2473 323 53 728 3416 4529 640 1718 M14214 GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. 37/71 Gene Ontology BP GO:0043124 1.49312588037517e-05 3.4714989797606e-05 2855 2029.18181818182 1872 1.35739637656453e-06 726 1.2557880056523 -1.06946255038413 -1 6.63405138151079 2855 902 2599 1413 1872 1417 4231 2339 726 2636 1331 1719 M10106 GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 12/37 Gene Ontology BP GO:0010831 3.16614536732824e-05 6.55254442915524e-05 2345 2053.27272727273 1873 2.87835539458958e-06 840 1.48216632188149 -1.68925200243943 -1 7.34554564945583 2344 840 1873 1546 2116 3009 4228 989 1760 1642 2239 1720 M13833 GO_POSITIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEATH.html Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 414/961 Gene Ontology BP GO:0010942 5.23488568837613e-07 2.9677135837766e-06 2295 1676.81818181818 1876 4.75898812183109e-08 335 1.62425224026453 1.79216668782122 1 10.6357075810608 1551 2295 668 1876 678 3063 2291 1871 1921 335 1896 1721 M15853 GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION.html A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. 195/501 Gene Ontology BP GO:0023014 1.41138825994485e-07 1.47591794840629e-06 3940 2265.18181818182 1876 1.28308031862825e-08 197 1.45288288921076 -1.37522504411102 -1 10.0356855634568 3939 2333 1876 1496 197 1433 4373 3748 2673 999 1850 1722 M12361 GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. 22/51 Gene Ontology BP GO:0050850 1.2606166690603e-05 3.01082468850154e-05 1720 1925 1878 1.14602172049753e-06 805 1.56305815414877 1.98021931536805 1 8.3717812357587 1717 2503 1878 2756 1818 2430 1469 805 1988 2303 1508 1723 M15157 GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that activates or increases the frequency, rate, or extent of peptide secretion. 47/128 Gene Ontology BP GO:0002793 2.52386627536702e-05 5.4352092377222e-05 1880 1778.09090909091 1878 2.29445020902491e-06 753 1.76573454615701 2.08157525315842 1 8.92073106263189 1878 1922 1052 1277 2025 2707 2564 2163 1353 753 1865 1724 M12823 GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 29/68 Gene Ontology BP GO:0051898 8.08556255386537e-07 3.80357314464001e-06 1300 1683.18181818182 1879 7.35051411410718e-08 621 1.42480619854666 1.70188460585825 1 9.14782267670461 1297 1792 2221 621 868 2403 2156 1949 1296 2033 1879 1725 M11342 GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. 63/351 Gene Ontology BP GO:0002460 2.06555537745374e-07 1.84785618834638e-06 1885 2128.90909090909 1881 1.8777777921695e-08 312 1.41294719547031 -1.19784200903847 -1 9.5964595202619 4079 967 1302 1653 312 1881 3279 3434 1885 1046 3580 1726 M15300 GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a humoral immune response. 6/19 Gene Ontology BP GO:0002922 0.000193109541697288 0.000330851513690224 1885 1861.36363636364 1881 1.93126324832739e-05 253 2.1990497155092 -2.82895656060451 -1 9.06646721397317 1881 1953 4382 1693 2934 1340 1982 562 253 2198 1297 1727 M14828 GO_MEMBRANE_HYPERPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_HYPERPOLARIZATION.html The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. 8/21 Gene Ontology BP GO:0060081 2.72800910010542e-07 2.12163253798819e-06 2340 2077.81818181818 1882 2.72800943499699e-08 437 1.34108512798349 -1.4101907868057 -1 9.013062862358 2338 1720 4299 1882 437 2333 4082 883 1093 1752 2037 1728 M12165 GO_HYPOTHALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPOTHALAMUS_DEVELOPMENT.html The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. 8/35 Gene Ontology BP GO:0021854 6.88676732325088e-07 3.45678493857879e-06 1885 1824 1883 6.88676945749218e-08 337 1.78047732790036 1.78047732790036 1 11.5189453508738 1883 337 3863 728 846 2868 2058 2005 2111 1738 1627 1729 M14679 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of production of a cytokine. 206/572 Gene Ontology BP GO:0001819 1.02510747517719e-06 4.49016415778085e-06 3170 2055.09090909091 1883 9.31916320758611e-08 854 1.50112733906167 -1.40472321671103 -1 9.50967475121046 3167 1883 854 1799 950 1567 3444 2668 2714 1011 2549 1730 M10616 GO_RESPONSE_TO_PROSTAGLANDIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 19/86 Gene Ontology BP GO:0034695 0.00883935034057274 0.0118137891857453 735 2153.81818181818 1885 0.000806824265140716 731 1.46832238779418 1.46832238779418 1 3.35288495120715 731 3213 1279 2146 3348 1217 1125 1885 3968 3620 1160 1731 M11364 GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. 10/25 Gene Ontology BP GO:0050774 9.16251992448112e-05 0.000167883109744932 4375 2206.54545454545 1885 8.32991049608475e-06 1134 1.82322355357588 -1.65667577616324 -1 8.15331243560884 4372 2322 1885 1258 2409 4005 1134 1515 1138 1367 2867 1732 M14798 GO_SOMATIC_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_DIVISION.html The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. 12/39 Gene Ontology BP GO:0048103 6.87653282150191e-07 3.45538332145383e-06 2920 2250 1886 6.25139542808951e-08 741 1.54773008847444 1.43828928299875 1 10.0134905389093 2919 1016 1358 1529 802 4020 3697 4417 1886 741 2365 1733 M12589 GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. 12/36 Gene Ontology BP GO:0042088 2.97607164169589e-05 6.21867715229255e-05 1265 1729.72727272727 1888 2.70555627414569e-06 757 1.29141736000463 -1.50226444683549 -1 6.43494823659293 1265 2200 2372 1263 2094 877 1888 757 2268 3046 997 1734 M13138 GO_POSITIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of exocytosis. 46/117 Gene Ontology BP GO:0045921 4.9785620675777e-07 2.89304927155986e-06 4240 2475.54545454545 1888 4.52596654019824e-08 652 1.4459029480115 1.59339343056814 1 9.48681939220917 4237 1541 1888 1435 652 2640 4182 3942 1818 1126 3770 1735 M10200 GO_N_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_GLYCAN_PROCESSING.html The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. 11/20 Gene Ontology BP GO:0006491 1.57987427682007e-05 3.64399218443895e-05 1165 1856.90909090909 1889 1.43625965672827e-06 249 1.30753473163907 1.30753473163907 1 6.87479696111134 1163 2638 2420 2573 1889 1237 973 249 3938 2224 1122 1736 M13915 GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT.html Any apoptotic process that is involved in anatomical structure development. 16/38 Gene Ontology BP GO:1902742 0.000289160236527087 0.000477443448860336 1580 1996.54545454545 1889 2.62907499748368e-05 517 1.38741493232092 1.79926389128229 1 5.4583755882142 1576 1705 1944 1889 3705 2322 2951 1517 1576 2260 517 1737 M14662 GO_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_ANION_GENERATION.html The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. 6/16 Gene Ontology BP GO:0042554 0.000171499305918362 0.000295462440585883 3190 2078.45454545455 1889 1.71512542761489e-05 1032 1.90256411872086 -1.97222129642606 -1 7.95481744293192 3187 1032 4268 1058 2576 1828 1889 1936 1192 1310 2587 1738 M14680 GO_RESPONSE_TO_YEAST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_YEAST.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. 8/22 Gene Ontology BP GO:0001878 0.000102513746245763 0.00018549155254056 2035 2198.90909090909 1889 1.02518475633499e-05 174 2.26191204107038 1.82932545244234 1 9.9990250109047 2032 174 4272 1744 2461 1889 1191 4537 2304 1751 1833 1739 M11851 GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). 53/127 Gene Ontology BP GO:0043648 4.93317524720444e-07 2.88338993019097e-06 1615 1922.54545454545 1891 4.48470577581501e-08 645 1.45021434903645 -1.27280093521558 -1 9.51760248522242 1614 2339 2323 2390 645 1047 1263 3794 2035 1891 1807 1740 M15869 GO_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of sprouting angiogenesis. 23/46 Gene Ontology BP GO:1903670 4.58734854665269e-05 9.08866537380195e-05 695 1497.18181818182 1891 4.17040382084552e-06 356 1.51124328748243 1.60691079722127 1 7.23527356626701 694 2631 1901 1891 2432 897 844 356 2097 1900 826 1741 M16054 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the rate of production of a cytokine. 119/317 Gene Ontology BP GO:0001818 5.6120661323633e-07 3.10518604170987e-06 3730 2511.81818181818 1891 5.10187960360703e-08 704 1.69324080606117 -1.4990736831943 -1 11.0480030170271 3726 1606 704 1826 709 4260 3967 3910 1891 734 4297 1742 M11979 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. 27/79 Gene Ontology BP GO:2000107 1.28509406760902e-05 3.05984192610702e-05 1895 1991.18181818182 1892 1.16827415848865e-06 1006 1.8900111750879 2.0882741195101 1 10.1072478465483 1892 2589 1075 1837 1825 3304 2428 2379 2334 1006 1234 1743 M12639 GO_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that modulates the frequency, rate or extent of receptor internalization. 17/56 Gene Ontology BP GO:0002090 7.61536195971202e-06 1.97408945586421e-05 3395 2078.63636363636 1892 6.92308029148151e-07 941 1.58157876943984 -1.328534716929 -1 8.81443768249372 3394 2351 1798 1619 1679 1892 2275 2121 941 1793 3002 1744 M12910 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. 42/120 Gene Ontology BP GO:0002708 8.00958032663815e-05 0.00014833857780846 1120 1916.90909090909 1892 7.28170177069212e-06 711 1.441621310732 -1.29757987672001 -1 6.53861440788899 1119 2751 1892 2524 2382 711 1482 1302 2992 2609 1322 1745 M14774 GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. 154/403 Gene Ontology BP GO:0002831 1.77481056215758e-06 6.53484967493867e-06 1995 1838.54545454545 1892 1.61346544905073e-07 728 1.5797172040879 -1.44260954390817 -1 9.70256141984657 1995 2575 1858 2425 1170 728 2281 1978 1791 1892 1531 1746 M15642 GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that modulates the frequency, rate or extent of response to oxidative stress. 36/89 Gene Ontology BP GO:1902882 7.19525675984617e-08 9.9289994586904e-07 2540 1845.54545454545 1892 6.54114272288382e-09 65 1.91963909316543 -1.73356368069295 -1 13.6512624067507 2538 2428 1588 1299 65 2642 1800 2920 972 2157 1892 1747 M10609 GO_SODIUM_ION_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_EXPORT.html The directed movement of sodium ions out of a cell or organelle. 4/15 Gene Ontology BP GO:0071436 3.38152722469251e-05 6.93175757361912e-05 3970 2014.81818181818 1893 3.3815786820632e-06 94 1.8273092380515 -2.28976312783162 -1 9.00316784301026 3969 489 3611 792 2160 4457 1893 481 94 1695 2522 1748 M12127 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an external stimulus. 156/449 Gene Ontology BP GO:0032103 2.58925531610098e-07 2.0620776042293e-06 1895 1717.18181818182 1894 2.35386874621759e-08 230 1.56509375270819 1.64845691770151 1 10.5414887304287 1894 230 412 1051 392 3612 2979 2684 2215 447 2973 1749 M13142 GO_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_IMPORT.html The directed movement of the hexose monosaccharide glucose into a cell or organelle. 9/18 Gene Ontology BP GO:0046323 1.45677890392469e-05 3.39719962376812e-05 2555 1993.72727272727 1897 1.45678845393428e-06 986 1.54447468383671 1.56736477224538 1 8.17631087459572 2555 1582 4020 1477 1897 2579 1225 2281 986 1199 2130 1750 M12105 GO_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_OLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 258/614 Gene Ontology BP GO:0051259 4.63768037765335e-07 2.80251696730727e-06 3640 2212.18181818182 1898 4.21607395935782e-08 22 1.63660600146741 1.88250815523597 1 10.7648248119558 3640 22 654 1898 622 3285 4238 3546 1803 487 4139 1751 M13359 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. 87/215 Gene Ontology BP GO:0051092 5.27259805575472e-05 0.000102816769310664 2965 1975.09090909091 1898 4.7933858408641e-06 762 1.5949212166186 -1.59375164117754 -1 7.53469062931347 2963 2652 1720 1807 2259 949 1898 2820 2241 762 1655 1752 M14597 GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS.html A biological process that directly contributes to the process of producing new individuals, involving another organism. 405/1478 Gene Ontology BP GO:0044703 7.61890721304994e-07 3.66370740073268e-06 2180 1697.45454545455 1898 6.92628168325924e-08 408 1.75188501800469 1.93097365235037 1 11.2815666228464 2178 2573 408 1680 847 2626 2306 2620 1898 1005 531 1753 M13868 GO_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 23/71 Gene Ontology BP GO:0098900 0.00241932723008189 0.00344674327378651 640 1700.27272727273 1899 0.00022018107758877 638 1.94846457189239 1.74356764647945 1 5.68411408314341 736 2550 1262 2286 3086 638 638 1934 2101 1899 1573 1754 M10720 GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 28/91 Gene Ontology BP GO:0048168 1.60528205981258e-07 1.59259072728843e-06 2490 1747.18181818182 1900 1.45934743358709e-08 230 1.56075086629548 1.6797168659615 1 10.7196850418321 2486 1900 1811 666 230 2834 1278 1902 1026 1948 3138 1755 M10942 GO_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. 23/56 Gene Ontology BP GO:0046632 2.34204089947046e-06 7.94309415357294e-06 2875 2139.18181818182 1902 2.12913035702429e-07 1278 1.2496324920754 -1.12064180965065 -1 7.54972905853434 2872 1795 1709 1282 1278 1902 2856 2622 2343 1897 2975 1756 M13384 GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 42/93 Gene Ontology BP GO:0046823 1.1854447643898e-06 4.96304782782855e-06 1010 1846.54545454545 1902 1.07767763923055e-07 1007 1.23538589177848 -0.797738645072625 -1 7.76255617485868 1902 1923 2444 1804 1010 2450 1007 1489 1938 2610 1735 1757 M14506 GO_AMMONIUM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSPORT.html The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 27/97 Gene Ontology BP GO:0015696 2.65685374565176e-05 5.66901284056118e-05 1750 1910.18181818182 1902 2.41535075634116e-06 706 1.32841921402777 -1.38701638196154 -1 6.68256987169129 1750 1902 1683 2212 2046 706 2326 898 3314 3221 954 1758 M16677 GO_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERK1_AND_ERK2_CASCADE.html An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 14/29 Gene Ontology BP GO:0070371 4.45128718133195e-07 2.74343418554066e-06 3350 2065.27272727273 1903 4.04662552906059e-08 601 1.84038521801441 1.76894939151463 1 12.1253633846954 3350 1200 1014 968 601 3569 1903 2531 2349 937 4296 1759 M10325 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. 9/25 Gene Ontology BP GO:0061339 9.99352164846757e-07 4.40645023873076e-06 3425 2283.18181818182 1904 9.99352614264179e-08 982 1.29281617998685 -1.31642581969772 -1 8.20253616013033 3422 1292 3566 1702 982 2792 3652 1403 1369 1904 3031 1760 M12421 GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. 18/47 Gene Ontology BP GO:2001258 6.68230873439774e-07 3.41753794909904e-06 1705 1898.45454545455 1905 6.07482796735617e-08 784 1.25496042374843 1.5988245157983 1 8.12644208307648 1701 924 1905 2154 784 2241 1896 3025 2769 1344 2140 1761 M10562 GO_REGULATION_OF_PODOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PODOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of podosome assembly. 9/27 Gene Ontology BP GO:0071801 5.11468663257706e-06 1.42885018261464e-05 4160 2107.27272727273 1906 5.1146984046239e-07 181 1.42942299546264 -1.65672896012102 -1 8.20415300250738 4156 603 3603 452 1594 3349 2916 1320 181 1906 3100 1762 M11676 GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION.html Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. 18/49 Gene Ontology BP GO:0097035 1.66119510867434e-05 3.80885377262962e-05 1910 1909.09090909091 1906 1.51018877482114e-06 1107 2.1133537597379 -2.09286043856874 -1 11.0635487420739 2898 1338 1107 2533 1906 1910 2329 1207 1323 1341 3108 1763 M14825 GO_BODY_FLUID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_FLUID_SECRETION.html The controlled release of a fluid by a cell or tissue in an animal. 42/126 Gene Ontology BP GO:0007589 3.27282122771714e-06 1.01372307940565e-05 2630 1772.63636363636 1908 2.97529645138794e-07 842 2.14061516771269 -2.41379189390842 -1 12.6640377163927 2627 2498 842 2618 1402 1042 2387 983 2030 1162 1908 1764 M11385 GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 38/160 Gene Ontology BP GO:0001676 1.68663728842826e-05 3.85956477583657e-05 695 1695.90909090909 1909 1.53331838111609e-06 449 1.56830212565626 -1.53354477880188 -1 8.19949494483996 695 2342 2021 3386 1909 449 803 753 2783 2716 798 1765 M12122 GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. 9/29 Gene Ontology BP GO:0048557 0.000355196764995718 0.000576232907014367 1805 2127.72727272727 1911 3.55253551904639e-05 1458 1.66265273443256 1.99208925170451 1 6.38034814298418 1803 2240 3852 1458 2727 2396 1986 1772 1790 1911 1470 1766 M16346 GO_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGIONALIZATION.html The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 132/438 Gene Ontology BP GO:0003002 8.90231790057548e-08 1.14815172256589e-06 1095 1973.18181818182 1913 8.093016600735e-09 99 1.59773070209049 1.70094682098992 1 11.2426350952557 1092 3395 1145 3487 99 1722 965 2103 3041 2743 1913 1767 M11929 GO_RESPONSE_TO_INTERFERON_ALPHA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_ALPHA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. 18/37 Gene Ontology BP GO:0035455 1.95139512488938e-06 7.018069376345e-06 2530 2156.45454545455 1914 1.77399714161335e-07 886 1.28312172595966 -0.959787975036902 -1 7.83379027051238 2529 1340 2295 1742 1200 3843 1914 3485 886 1874 2613 1768 M12673 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that modulates the frequency, rate or extent of protein localization to the cell surface. 21/46 Gene Ontology BP GO:2000008 1.72322459064647e-06 6.39562891636417e-06 2535 2053.63636363636 1914 1.56656903674731e-07 390 2.05967503388243 -1.91438432357629 -1 12.673263227228 2535 1693 1914 975 1160 3202 2544 3833 390 1683 2661 1769 M12943 GO_PLATELET_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_MORPHOGENESIS.html Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. 17/38 Gene Ontology BP GO:0036344 1.71075087294082e-05 3.90512109295193e-05 2355 1833.36363636364 1914 1.55524016011319e-06 333 2.09396336757302 2.68432607887224 1 10.9351491004061 2352 1701 1690 1633 1914 2366 2597 1138 333 2325 2118 1770 M15341 GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of cell projection assembly. 109/259 Gene Ontology BP GO:0060491 9.49183812142169e-07 4.24572296702899e-06 1520 1841.81818181818 1916 8.62894746968275e-08 930 1.49338983532092 1.66882924142614 1 9.50366519990858 1520 2383 1877 2293 930 1916 1059 1641 2340 2284 2017 1771 M15665 GO_ASPARTATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. 5/12 Gene Ontology BP GO:0006531 0.000918136885888595 0.00138766587278019 875 2012 1917 9.18516445519607e-05 456 0.964699742099544 -0.964699742099544 -1 3.26579536917917 873 1917 4435 2936 3286 559 456 1203 3737 1989 741 1772 M15947 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS.html Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. 9/37 Gene Ontology BP GO:1901522 0.000324097278217499 0.000530600727349734 1730 2201.54545454545 1917 3.24144555492583e-05 1211 1.32555558717851 1.47807668242444 1 5.14301740254717 1729 2443 4484 1338 2703 1891 2551 1917 2290 1211 1660 1773 M16307 GO_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS.html An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. 100/443 Gene Ontology BP GO:0006909 2.72816684600597e-06 8.83324872106395e-06 1370 1801.72727272727 1918 2.48015475376875e-07 630 2.09282979225882 2.31561295910917 1 12.5295893856209 1368 2384 630 1918 1340 2373 1973 2228 1415 1174 3016 1774 M15245 GO_LINOLEIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LINOLEIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 10/30 Gene Ontology BP GO:0043651 0.000176328255213229 0.000303556577291443 1935 1843.27272727273 1919 1.60311263062767e-05 1086 1.89319443874059 -1.88185386101084 -1 7.88931831171325 1932 1206 2053 2934 2567 1117 1086 1158 1919 2837 1467 1775 M10249 GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT.html The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. 80/195 Gene Ontology BP GO:0061008 9.09760577877682e-07 4.14525845248879e-06 4010 2448.27272727273 1920 8.27055412808135e-08 549 1.70471952759487 -1.54707638707921 -1 10.8695319754778 4008 1920 1053 549 907 3470 4580 3597 1875 976 3996 1776 M12991 GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. 24/68 Gene Ontology BP GO:0001914 0.0240895255529516 0.0307020771733062 1405 2140.72727272727 1921 0.00221431058716985 1088 1.94232690842444 -1.81963961058246 -1 3.48089553683287 1402 3338 1921 2597 3721 1088 1796 1538 2218 2038 1891 1777 M14854 GO_PHARYNGEAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHARYNGEAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. 8/36 Gene Ontology BP GO:0060037 0.000428443285334429 0.000686899921894942 1925 2086.45454545455 1921 4.28525911397615e-05 682 1.70628066226077 -2.01877546622503 -1 6.39355308454068 1921 1660 4305 2441 2877 1601 2142 682 1354 2537 1431 1778 M10649 GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. 52/130 Gene Ontology BP GO:2000106 1.0606157926517e-06 4.57862597058646e-06 1860 1754.36363636364 1922 9.64196639975359e-08 783 1.93325639410215 2.30035710804263 1 12.2278178304177 1856 2010 783 2018 969 3161 2060 2169 1922 973 1377 1779 M12545 GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. 25/62 Gene Ontology BP GO:1903523 2.1391613630694e-07 1.8810845092294e-06 2770 1995 1922 1.94469233733631e-08 324 1.35760035282777 -1.1621198047617 -1 9.20810660549012 2769 804 1663 1412 324 2468 1922 2728 2912 1606 3337 1780 M15219 GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. 9/22 Gene Ontology BP GO:0010310 0.0365768445863198 0.0457752801655748 1380 2285.36363636364 1922 0.00371932112463735 1380 2.34542949543931 -2.34542949543931 -1 3.72135007657021 1380 2482 4372 2576 3966 1425 2162 1787 1443 1922 1624 1781 M11343 GO_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_ARREST.html A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). 85/219 Gene Ontology BP GO:0007050 3.45875936781681e-06 1.05850697483504e-05 1790 1989.90909090909 1925 3.14433164142136e-07 1422 1.3797630965353 1.38627504604126 1 8.13209339219655 1790 2251 2425 2285 1422 2522 1616 1925 2158 1635 1860 1782 M16170 GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. 30/62 Gene Ontology BP GO:0060603 6.13129064572911e-06 1.65316971359583e-05 3000 2025.09090909091 1925 5.57391612127095e-07 365 1.94832596311805 1.97831083493414 1 11.0362211552563 2999 1925 977 400 1614 3943 3196 2443 365 724 3690 1783 M16943 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. 51/143 Gene Ontology BP GO:0002705 3.15609476688078e-05 6.54185178688725e-05 1720 2130.81818181818 1925 2.86921822251244e-06 969 1.45252785944927 -1.29757987672001 -1 7.19987924890408 1720 2806 1779 2686 2113 969 1925 1710 3221 2762 1748 1784 M11127 GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of endothelial cell differentiation. 13/40 Gene Ontology BP GO:0045601 3.96121156638074e-06 1.16848191249719e-05 2435 1846.36363636364 1926 3.60110790796457e-07 857 1.97692137272839 -1.98913052843406 -1 11.5511118078733 2434 932 935 2431 1480 1926 2738 1881 2663 857 2033 1785 M12081 GO_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSPORT.html The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 198/632 Gene Ontology BP GO:0006820 6.53019603023409e-08 9.30052152404199e-07 1930 1925.90909090909 1928 5.93654202188001e-09 246 1.71035824814211 1.81712574720764 1 12.2205269922684 1928 1061 246 1420 967 4060 2867 3513 2002 366 2755 1786 M15060 GO_COCHLEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_MORPHOGENESIS.html The process in which the cochlea is generated and organized. 10/37 Gene Ontology BP GO:0090103 1.59837376943975e-06 6.08798146965442e-06 2965 2005.54545454545 1928 1.45306811883006e-07 162 1.4888484409226 1.53683355961534 1 9.19870484314819 2964 162 804 496 1122 4203 2694 4306 1928 392 2990 1787 M13875 GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. 48/104 Gene Ontology BP GO:0045639 5.97415683823337e-07 3.22535002324623e-06 3875 2393.90909090909 1929 5.43105314593792e-08 436 1.82988050394957 -1.87767273912851 -1 11.9038016143963 3875 1748 577 1245 731 4089 4185 2960 1929 436 4558 1788 M15808 GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. 11/49 Gene Ontology BP GO:0045721 3.15566553772872e-05 6.54185178688725e-05 1935 2058.54545454545 1931 2.86882800299705e-06 968 1.3764822924692 1.3764822924692 1 6.82293706222065 1931 1116 1822 2906 2112 2886 1698 968 3299 2244 1662 1789 M16897 GO_FATTY_ACID_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_ELONGATION.html The elongation of a fatty acid chain by the sequential addition of two-carbon units. 7/13 Gene Ontology BP GO:0030497 1.06323168664717e-05 2.60643332687584e-05 2510 1951.36363636364 1931 1.06323677375872e-06 33 2.35289212495383 3.06662539121257 1 12.7767457525315 2507 1217 4634 584 1931 3115 3411 210 33 2413 1410 1790 M13027 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION.html Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. 11/34 Gene Ontology BP GO:0060142 0.00101141654583313 0.00151484097493652 1480 2227.63636363636 1932 9.19892571551815e-05 237 1.16813893133093 1.21563977188695 1 3.90179987671257 1479 2319 1932 3800 4597 919 237 1530 3969 2234 1488 1791 M12491 GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 18/41 Gene Ontology BP GO:0035710 3.52207600562825e-06 1.06812533599817e-05 1860 1902.27272727273 1933 3.20189240389642e-07 1322 1.26640606079708 -1.25773970523729 -1 7.45809225533587 1857 2154 2085 2162 1433 1322 1810 1933 2286 1875 2008 1792 M11191 GO_POSITIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_GROWTH.html Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 16/45 Gene Ontology BP GO:0060421 1.81383406567672e-05 4.11011789504003e-05 2235 2085.45454545455 1934 1.64895365487963e-06 1171 2.57434693380598 -1.57525848650068 -1 13.3760590615198 2234 1855 1171 1771 1934 3040 2758 1646 1634 2253 2644 1793 M11766 GO_SPERM_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MOTILITY.html Any process involved in the controlled movement of a sperm cell. 34/121 Gene Ontology BP GO:0030317 9.31850612457782e-06 2.32987743330182e-05 1900 2370.81818181818 1934 8.47140508642253e-07 755 1.80761967195236 1.34433277062014 1 9.92010259961321 3293 3396 1934 1746 1738 2955 1899 1898 755 2430 4035 1794 M12959 GO_REGULATION_OF_CHEMOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_SECRETION.html Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. 5/20 Gene Ontology BP GO:0090196 0.00021216681325715 0.000360839016099981 1285 2113.54545454545 1935 2.12187072619992e-05 578 3.07897679076637 -3.07897679076637 -1 12.5568855678193 1284 3236 3986 2536 4029 790 938 578 1935 2984 953 1795 M14609 GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 12/29 Gene Ontology BP GO:0010888 3.90945067680654e-05 7.89542387664757e-05 1565 1923.09090909091 1935 3.55410922761273e-06 1186 2.22321257317974 2.01972672204406 1 10.8049011587381 1562 1647 1186 2635 2177 1935 1256 2240 2507 1657 2352 1796 M12658 GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 17/48 Gene Ontology BP GO:0097237 0.000322408021324458 0.000528021320285524 925 1941.90909090909 1936 2.93141163296564e-05 535 1.56500982408087 1.56500982408087 1 6.07599880798999 922 3289 2307 1936 3500 1260 839 1061 2806 2906 535 1797 M15995 GO_MESENCHYME_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_MORPHOGENESIS.html The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. 23/58 Gene Ontology BP GO:0072132 3.93396429014883e-05 7.9380252929861e-05 2695 1663.81818181818 1937 3.57639512518687e-06 339 2.96453795112701 4.28330559425558 1 14.3995651426042 2693 448 736 560 2179 3430 2065 2014 339 1901 1937 1798 M16363 GO_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of JUN kinase activity. 56/166 Gene Ontology BP GO:0043506 2.42415783206379e-06 8.15606145961751e-06 1895 2127.18181818182 1937 2.20378227565727e-07 1290 1.75790866738876 1.85330053482644 1 10.5965815363545 1893 2619 1801 1937 1290 2462 1735 2233 1808 2741 2880 1799 M14135 GO_DETECTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS.html The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. 23/106 Gene Ontology BP GO:0009583 1.8294485444745e-05 4.1394393723173e-05 4070 2449.36363636364 1938 1.66314887068319e-06 598 1.75815769145634 -1.74078901608116 -1 9.12878778287285 4070 1481 766 854 1938 4275 3329 4427 815 598 4390 1800 M10074 GO_FOREBRAIN_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. 16/71 Gene Ontology BP GO:0021884 0.00104451819768802 0.00156139664902301 2600 1981.81818181818 1940 9.50013131786329e-05 828 1.82432886955002 -1.7198300979376 -1 6.06518579675561 2596 1702 1129 1455 3634 1940 2994 828 2170 1139 2213 1801 M12765 GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive nitrogen species. 9/26 Gene Ontology BP GO:2001057 0.00264234675058061 0.00374951588109589 1940 2220.36363636364 1940 0.000264549391695544 1255 1.35967877042948 -1.56007858931527 -1 3.9075943052791 1940 1869 3957 1285 3114 1721 2014 1536 3051 2682 1255 1802 M14703 GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. 10/18 Gene Ontology BP GO:0045653 0.00582328171627175 0.00794052775584426 600 1921.36363636364 1940 0.000530795726601821 600 1.0754147714596 -1.0754147714596 -1 2.67549578719372 600 1940 2075 2466 3273 644 1350 1604 3927 2081 1175 1803 M15003 GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 43/87 Gene Ontology BP GO:0030148 4.99462571915657e-06 1.40036516993019e-05 1740 2161.09090909091 1941 4.54057914401232e-07 1215 1.30953488502468 1.43162820858064 1 7.52962346330578 1736 1392 1891 1941 1561 2710 2188 3654 2715 1215 2769 1804 M11324 GO_PITUITARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PITUITARY_GLAND_DEVELOPMENT.html The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. 17/63 Gene Ontology BP GO:0021983 1.85126371491011e-05 4.17969549285159e-05 2840 1767.27272727273 1942 1.68298117561133e-06 283 2.18960001399729 -1.8669159129023 -1 11.3580407971074 2838 1193 938 283 1942 2074 3069 2589 603 1232 2679 1805 M16710 GO_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 90/182 Gene Ontology BP GO:0042542 8.95348859457803e-06 2.25195273806207e-05 2410 2329.63636363636 1943 8.13956821218447e-07 643 1.65964083041293 1.85630241815566 1 9.13704980407225 2406 643 1016 1776 1726 4569 3981 1820 2389 1943 3357 1806 M10283 GO_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. 168/410 Gene Ontology BP GO:0006644 3.74910972570419e-07 2.5617691856508e-06 2985 2218.72727272727 1944 3.40828214964128e-08 510 1.52885848119044 -1.34666649072437 -1 10.1267604999248 2983 2533 1917 1944 510 1736 3836 3045 1837 1588 2477 1807 M10955 GO_GLUTAMATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. 14/33 Gene Ontology BP GO:0006536 6.39664118568623e-06 1.71182047075419e-05 4620 2379.36363636364 1945 5.81514525855154e-07 651 1.59940808316992 -1.04715672866595 -1 9.0311012610061 4618 701 1945 1565 1629 3995 3963 1987 651 1382 3737 1808 M13177 GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION.html A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. 9/20 Gene Ontology BP GO:0014829 0.000737959786494715 0.00113605679333387 1540 2025.63636363636 1945 7.38204964183193e-05 689 5.02790383837703 5.02790383837703 1 17.5384546606499 1537 1945 4029 2043 2881 1576 1360 2185 689 2686 1351 1809 M14010 GO_RESPONSE_TO_CARBOHYDRATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CARBOHYDRATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 106/256 Gene Ontology BP GO:0009743 3.1744521199191e-06 9.89336594135278e-06 925 1852.81818181818 1945 2.88586972768126e-07 921 1.44201404887465 1.54701572267815 1 8.54912628879759 921 1531 1846 1968 1395 1978 1997 3003 2274 1945 1523 1810 M13810 GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS.html Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. 17/71 Gene Ontology BP GO:0021952 8.87633074028559e-05 0.000162916071005503 1685 1987.45454545455 1949 8.06971717587189e-06 711 1.72840573878896 1.73463279296716 1 7.75600022681736 1685 3770 1949 1981 2403 1809 711 2513 1269 1798 1974 1811 M15536 GO_MYELIN_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_MAINTENANCE.html The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. 7/14 Gene Ontology BP GO:0043217 0.000327026527807974 0.000533890354645718 2510 2124 1949 3.27074663635462e-05 842 1.72515803271524 1.39655315078637 1 6.68794807303606 2506 1949 4419 842 2710 2826 1290 1213 1332 2400 1877 1812 M16728 GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. 185/481 Gene Ontology BP GO:0002237 1.15186001612512e-07 1.31726257509087e-06 1955 1989 1951 1.04714552403034e-08 257 1.6628437904412 1.68551712199056 1 11.5832656584301 1951 1147 257 952 713 3865 2921 4067 2260 590 3156 1813 M16828 GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION.html Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. 17/26 Gene Ontology BP GO:2000615 0.000740866481214772 0.0011401534876633 940 1925.54545454545 1951 6.73741901128807e-05 491 1.2530808002148 1.33169738765335 1 4.36870465249426 1240 2402 1951 2545 2861 938 491 939 3244 3472 1098 1814 M11631 GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that activates or increases the rate of neuroblast proliferation. 11/33 Gene Ontology BP GO:0002052 0.000220955850135146 0.000374278734833085 2335 2002.90909090909 1952 2.00889131673901e-05 1378 1.59082065089765 1.69037777930169 1 6.4578593375203 2332 1503 1966 1671 2612 2486 1378 2963 1952 1532 1637 1815 M14489 GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 35/109 Gene Ontology BP GO:0010830 4.08502156326659e-07 2.61980478260637e-06 3745 2095.81818181818 1952 3.7136566561682e-08 566 1.58973840338029 -1.67474907578179 -1 10.5116914838297 3743 904 930 1952 566 3034 3985 1863 2117 791 3169 1816 M10449 GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any negative regulation of signal transduction that takes place in extracellular region. 3/15 Gene Ontology BP GO:1900116 0.00796861767689455 0.0107086228288919 840 2108.36363636364 1954 0.000799733721518386 840 2.01606753937016 2.01606753937016 1 4.70552375018368 840 2081 3588 1954 3447 1084 864 1273 3820 2577 1664 1817 M13296 GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any regulation of signal transduction that takes place in the extracellular region. 3/15 Gene Ontology BP GO:1900115 0.00802005209687456 0.0107715076325683 845 2151.90909090909 1955 0.000804914453315062 841 2.01606753937016 2.01606753937016 1 4.69945069089272 841 2082 4047 1955 3448 1085 865 1276 3821 2586 1665 1818 M16879 GO_INOSITOL_LIPID_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_LIPID_MEDIATED_SIGNALING.html A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. 64/158 Gene Ontology BP GO:0048017 2.14832505391814e-07 1.88521887086125e-06 2080 1764.45454545455 1955 1.95302296700415e-08 326 1.86418373308185 2.00554953721697 1 12.6419714083218 2080 966 1061 725 326 3152 2812 2307 1132 1955 2893 1819 M11726 GO_PEPTIDYL_ARGININE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_MODIFICATION.html The modification of peptidyl-arginine. 9/19 Gene Ontology BP GO:0018195 0.00579244321219725 0.00790079724859925 1870 2278.09090909091 1956 0.000580759741498224 570 2.1095112941936 -2.1095112941936 -1 5.25364249063797 1867 2899 3795 2407 3241 1609 1394 1836 570 3485 1956 1820 M13914 GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. 278/639 Gene Ontology BP GO:0010256 2.62357864235429e-07 2.07508518573853e-06 3765 2520.36363636364 1956 2.3850717774777e-08 396 1.59766780955844 -1.33314433534911 -1 10.7557185417254 3763 1599 1740 1956 396 2523 4198 4327 1512 1526 4184 1821 M16933 GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. 232/511 Gene Ontology BP GO:2001233 1.43506840425319e-06 5.69002784026266e-06 2100 1865.54545454545 1956 1.3046084912315e-07 847 1.59928604333571 1.85052167158627 1 9.93665464879227 2097 1780 1631 2061 1079 3249 2286 1544 1991 1956 847 1822 M13069 GO_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JNK_CASCADE.html An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 39/112 Gene Ontology BP GO:0007254 6.04059081909256e-07 3.23212152206309e-06 2215 1889.27272727273 1957 5.49144770697471e-08 738 1.40059234096387 -1.37720657840476 -1 9.10966987536 2215 2188 2119 1957 738 1335 3359 1662 2387 1262 1560 1823 M13541 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 59/147 Gene Ontology BP GO:0010522 1.19088607141415e-06 4.97725870495785e-06 2060 1946.36363636364 1957 1.08262428732308e-07 1012 1.4919070277201 -1.2168280075029 -1 9.37221433374931 2059 1744 1294 1668 1012 2493 1516 2717 2977 1957 1973 1824 M12514 GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM.html Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. 262/924 Gene Ontology BP GO:0098542 1.19098307585789e-06 4.97725870495785e-06 2120 1849.27272727273 1958 1.08271247327649e-07 904 1.59264886279887 -1.57038212321328 -1 10.0050783276923 2120 1146 904 3385 1013 1111 2567 1444 2651 2043 1958 1825 M15707 GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. 27/60 Gene Ontology BP GO:0045668 6.00351973758469e-05 0.000115040619651695 2890 2300.72727272727 1959 5.45789415659048e-06 1291 1.68915435446923 -2.05030990557303 -1 7.88224139699968 2887 3597 1940 2877 2297 1959 3119 1291 1840 1828 1673 1826 M10602 GO_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_UPTAKE.html The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. 5/22 Gene Ontology BP GO:0001504 2.63273041198326e-06 8.63260402742817e-06 4325 2143.27272727273 1961 2.6327335310597e-07 24 2.01713234828317 -1.12499633161501 -1 12.1002395885565 4323 344 3610 378 1361 4240 3385 148 24 1961 3802 1827 M16306 GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of a defense response. 213/564 Gene Ontology BP GO:0031349 6.79350761564615e-07 3.4376343722032e-06 3250 2030.18181818182 1962 6.17591792132152e-08 795 1.60111534707 -1.4926830603121 -1 10.3631241581064 3249 1962 1197 1501 795 1559 2407 3331 2371 1189 2771 1828 M11869 GO_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORT.html The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 311/954 Gene Ontology BP GO:0006812 4.05137993964224e-07 2.61980478260637e-06 3140 2058.09090909091 1964 3.68307335065343e-08 137 1.57035038267088 1.71816694007394 1 10.3834937096855 3137 210 327 986 560 4087 3798 3849 1964 137 3584 1829 M16278 GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 10/19 Gene Ontology BP GO:0060315 4.18624166858485e-06 1.22089950171102e-05 2090 2005.90909090909 1964 3.80568148576556e-07 711 1.25769194051674 1.55831332103422 1 7.32027400496 1615 711 1964 1823 1499 2997 3020 2086 1941 2090 2319 1830 M13604 GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. 7/20 Gene Ontology BP GO:0060766 0.000755238874543128 0.00116034880691719 1590 2233.72727272727 1966 7.55495670972907e-05 724 1.21745204756454 1.21745204756454 1 4.2334923177122 1589 724 4103 890 2887 1966 1601 2636 3678 3282 1215 1831 M16025 GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. 20/37 Gene Ontology BP GO:0044803 5.60522967838002e-06 1.5360918167169e-05 45 1734 1966 5.09567632692061e-07 41 0.844962263794856 -0.763933682278937 -1 4.81818767809145 543 2592 2981 3397 1966 45 41 317 3894 3209 89 1832 M11556 GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. 5/20 Gene Ontology BP GO:2000846 0.000576149733072907 0.000906493802323792 1570 2100.36363636364 1968 5.76299164434233e-05 746 2.01945862956787 -2.01945862956787 -1 7.27885120685529 1567 2528 3768 2363 3208 1320 2395 746 1876 1968 1365 1833 M12592 GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 13/30 Gene Ontology BP GO:0034381 0.0095767929852544 0.0127370523719668 1875 2377.81818181818 1969 0.000874430677454734 1247 1.4729805053708 1.58481652929779 1 3.30649823720821 1875 1859 1621 1969 3561 3175 4488 1293 2962 1247 2106 1834 M12886 GO_REGULATION_OF_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCRINE_PROCESS.html Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 19/62 Gene Ontology BP GO:0044060 1.61813083721951e-05 3.72113990946517e-05 3085 2260.54545454545 1969 1.47103885356471e-06 750 1.75947980769748 1.66341771850658 1 9.23208425484758 3083 1411 1046 1913 1899 3676 3747 1969 2303 750 3069 1835 M13647 GO_BILE_ACID_AND_BILE_SALT_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_AND_BILE_SALT_TRANSPORT.html The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/63 Gene Ontology BP GO:0015721 1.9861591375365e-05 4.4133258209437e-05 3595 2580.09090909091 1969 1.80561551709095e-06 565 2.34892926657651 2.36425127048861 1 12.1187960101685 3591 1907 565 1476 1969 4539 4086 4164 1274 601 4209 1836 M16073 GO_POSITIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 198/563 Gene Ontology BP GO:0051047 2.96706512194108e-07 2.21837091162197e-06 2895 2080.27272727273 1969 2.69733229281739e-08 252 1.73419358272002 2.01829214537843 1 11.6152562036045 2891 873 286 533 1486 4382 3775 3231 1969 252 3205 1837 M16903 GO_PIGMENT_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_METABOLIC_PROCESS.html The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. 33/73 Gene Ontology BP GO:0042440 8.68908167331459e-06 2.19855074709535e-05 2795 2136.90909090909 1970 7.89919635613632e-07 951 1.84040091376815 -1.27783029827251 -1 10.1549368667494 2791 1970 2072 1538 1715 1230 1654 3458 951 2750 3377 1838 M11852 GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. 5/16 Gene Ontology BP GO:0048712 0.00164928916961786 0.00240126986971957 2490 2175.90909090909 1971 0.000165051451939467 98 2.24478606684998 2.88851526527842 1 6.96596269054549 2489 1450 3816 1627 3037 3762 3664 974 98 1971 1047 1839 M13454 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. 93/259 Gene Ontology BP GO:0031348 3.57574034796154e-07 2.49281718252034e-06 1420 1819.54545454545 1971 3.25067357194528e-08 492 1.45538640574613 1.88622378694427 1 9.66053007787163 1419 2051 1971 2371 492 2429 1737 862 2721 2050 1912 1840 M13952 GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE.html Any process that modulates the frequency, rate or extent of stem cell population maintenance. 7/22 Gene Ontology BP GO:2000036 3.82240983581154e-05 7.74321503825173e-05 1280 2134.81818181818 1971 3.82247558607955e-06 23 4.99164607132545 4.99164607132545 1 24.3095905862599 1280 3700 4164 2296 3883 1971 1447 341 23 3284 1094 1841 M14918 GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. 8/34 Gene Ontology BP GO:0022400 5.94280293576488e-05 0.000114065456927476 1755 2258.09090909091 1971 5.94296186782706e-06 1125 1.26460744515674 1.1676092704129 1 5.90668092384302 1962 1125 4317 2035 2324 1754 1381 3946 1971 1754 2270 1842 M10707 GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. 20/53 Gene Ontology BP GO:0034162 4.56312976546856e-05 9.049887167561e-05 1670 1827.72727272727 1972 4.14838583124379e-06 574 1.14937338190829 -1.35756424745081 -1 5.50530234191031 1670 1559 2569 1972 2218 1114 2458 574 2115 2639 1217 1843 M12316 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. 72/212 Gene Ontology BP GO:1902107 6.32638009386787e-05 0.000120679469087217 1685 1914.27272727273 1973 5.7514200220966e-06 715 1.64787392315784 -1.63427992299682 -1 7.64904215450781 1683 3028 1015 2015 2316 1510 1918 1973 2704 715 2180 1844 M14433 GO_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANOIKIS.html Any process that modulates the frequency, rate or extent of anoikis. 32/78 Gene Ontology BP GO:2000209 9.3418663080004e-08 1.18752475577845e-06 3855 2438.18181818182 1973 8.49260609516758e-09 107 1.6195050028598 -1.52356513360834 -1 11.367759499175 3852 1089 1199 1973 107 4320 3600 3894 1475 1074 4237 1845 M16287 GO_MESODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the mesoderm. 4/23 Gene Ontology BP GO:0001710 0.00078222827249524 0.00119745660046007 1215 2100.27272727273 1973 7.8250375546402e-05 975 1.28792233229841 1.28792233229841 1 4.45768329910085 1214 2828 4541 2253 2893 1382 975 1033 1973 2800 1211 1846 M13229 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. 15/31 Gene Ontology BP GO:0006356 2.06624782426439e-05 4.57491113402936e-05 1570 2060.36363636364 1975 1.87842475526601e-06 1013 1.50440370627109 1.50440370627109 1 7.73381603973922 1566 2511 2913 3072 1975 1702 1165 1268 2144 3335 1013 1847 M12464 GO_L_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_IMPORT.html The directed movement of L-enantiomer amino acids into a cell or organelle. 5/23 Gene Ontology BP GO:0043092 9.13126997031556e-06 2.29170197146893e-05 2050 1768.09090909091 1976 9.13130749157363e-07 204 3.15243710276685 3.15243710276685 1 17.3271712904711 2049 1302 3912 1209 2464 2441 2285 204 290 1976 1317 1848 M10129 GO_SYNAPTIC_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_LOCALIZATION.html Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. 57/155 Gene Ontology BP GO:0097479 5.41714746181612e-06 1.49446320054737e-05 2095 1964.45454545455 1977 4.92469163701787e-07 1346 1.6434188448711 2.01359116553468 1 9.39441921667704 2094 2009 1682 1485 1583 2876 2558 1977 1346 1463 2536 1849 M13083 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. 17/42 Gene Ontology BP GO:0032105 4.27457579482447e-06 1.24120421609569e-05 1635 2089.18181818182 1977 3.885985545728e-07 1179 1.38214073473552 1.81568271587592 1 8.03288774270265 1635 1851 2743 2181 1506 1886 1179 3118 1998 2907 1977 1850 M14725 GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to another cell. 128/357 Gene Ontology BP GO:0022409 1.47185588966591e-06 5.78647493286944e-06 3205 2218 1977 1.33805170397801e-07 514 1.6292023608487 -1.37183463214063 -1 10.1084419382332 3203 1463 580 1099 1088 4552 3588 2253 1977 514 4081 1851 M16938 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. 17/42 Gene Ontology BP GO:0032108 4.27457579482447e-06 1.24120421609569e-05 1640 2089.54545454545 1978 3.885985545728e-07 1180 1.38214073473552 1.81568271587592 1 8.03288774270265 1636 1852 2744 2182 1507 1887 1180 3108 1999 2912 1978 1852 M14902 GO_ORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT.html The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 12/23 Gene Ontology BP GO:0015695 2.08214490360089e-05 4.60571643040445e-05 2355 1994.72727272727 1979 1.89287691808694e-06 799 1.38757188925751 -1.50268364527296 -1 7.12841791471102 2355 1938 1868 2121 1979 2096 3754 799 2317 1658 1057 1853 M10111 GO_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSPORT.html The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 480/1474 Gene Ontology BP GO:0006811 2.21229250120946e-12 8.77920861804745e-11 2960 2016.09090909091 1980 2.01117500110153e-13 62 1.63986652202229 1.77920704311875 1 19.5359866321045 2958 360 108 941 686 4109 3557 3919 1980 62 3497 1854 M12654 GO_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. 79/246 Gene Ontology BP GO:0048469 2.91902283142573e-07 2.20016607245287e-06 1665 1945 1980 2.65365747157281e-08 428 1.56845831665215 1.64006187049341 1 10.5118461261283 1663 2252 706 2326 428 1833 1980 3980 2821 1131 2275 1855 M14243 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. 5/13 Gene Ontology BP GO:0052803 0.0123132216906923 0.0161634968362692 1030 2208 1980 0.00123819854884925 687 2.02075241596663 2.02075241596663 1 4.28843950036069 1026 2293 4212 3054 3332 867 687 1728 3717 1980 1392 1856 M16143 GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. 138/339 Gene Ontology BP GO:0034612 6.46283123540309e-06 1.72552762656564e-05 3575 2234.81818181818 1981 5.87531838274635e-07 1003 1.78831160630062 2.13081308008441 1 10.0904126127763 3573 1733 1003 2059 1634 2911 3511 1130 1981 1460 3588 1857 M11220 GO_THYMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMUS_DEVELOPMENT.html The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. 29/80 Gene Ontology BP GO:0048538 1.78936305928798e-05 4.06061226015352e-05 1515 2027.36363636364 1982 1.62670692107427e-06 1160 1.23688047230722 1.47199501873178 1 6.4344222456823 1513 2097 2475 1982 1930 1413 1160 2740 2355 2889 1747 1858 M11973 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. 72/218 Gene Ontology BP GO:0070665 2.12753204122692e-05 4.6971618009589e-05 4135 2457 1983 1.93413874183384e-06 714 1.4609108595515 -1.03169149439034 -1 7.4904080666049 4134 1611 1070 1661 1983 3975 4045 885 2400 714 4549 1859 M15526 GO_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_DEVELOPMENT.html The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 78/190 Gene Ontology BP GO:0001890 1.81204870717942e-07 1.72051986655093e-06 3965 2117.54545454545 1983 1.64731714220943e-08 263 1.91193776800629 -2.18666382822779 -1 13.0557375209831 3964 1610 528 1279 263 2542 4465 2596 1983 1078 2985 1860 M10171 GO_OLIGOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 33/71 Gene Ontology BP GO:0009311 2.47781966105829e-06 8.30051708967795e-06 3680 2419 1985 2.25256586525958e-07 670 1.65207980700063 -1.70823339888524 -1 9.94372851276215 3679 670 1303 1600 1296 4543 2825 3481 1985 903 4324 1861 M13546 GO_KERATAN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 7/15 Gene Ontology BP GO:0042340 0.00278197523047507 0.00394042434261615 1505 2042.27272727273 1985 0.000278546410293325 425 2.77505564762306 2.77505564762306 1 7.90436017975139 1501 1215 4095 1985 3127 2089 1924 2025 425 2388 1691 1862 M15314 GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. 5/16 Gene Ontology BP GO:0072505 5.86006461545641e-06 1.59579354894804e-05 1690 2195.72727272727 1985 5.86008006867455e-07 164 1.69132345722454 1.69132345722454 1 9.61117589385587 1689 3512 4384 2865 3630 2339 1633 164 852 1985 1100 1863 M12323 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of striated muscle contraction. 13/27 Gene Ontology BP GO:0045989 7.77654316278532e-05 0.000144831487785047 1525 2011.90909090909 1986 7.06983460094717e-06 1102 1.77639322890937 1.80048442200529 1 8.07887207792806 1523 2862 1986 2429 2373 1255 1218 1740 3168 2475 1102 1864 M16661 GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS.html Any process that alters the size or shape of an auditory receptor cell. 8/25 Gene Ontology BP GO:0002093 0.0104224164945121 0.0137866893971566 1370 2330.18181818182 1986 0.00104716236608618 748 1.85659186550526 -1.85659186550526 -1 4.09197884589222 1370 3227 4598 2591 4183 1470 1573 1336 748 2550 1986 1865 M13643 GO_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 55/151 Gene Ontology BP GO:0007219 2.34429002270108e-05 5.105318281145e-05 2770 1964.81818181818 1987 2.13119545773527e-06 833 1.90551950814849 2.35164020424655 1 9.68832791156777 2766 2214 1652 1788 2007 3197 2242 1256 833 1671 1987 1866 M14335 GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 10/39 Gene Ontology BP GO:0051350 3.17492273072204e-05 6.5646705916862e-05 725 1638 1987 2.88633504585479e-06 79 1.38904885728329 1.38904885728329 1 6.88273855664935 723 2672 1987 2580 2117 287 79 1287 3029 2830 427 1867 M14788 GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 11/27 Gene Ontology BP GO:0090322 1.08888296267917e-06 4.66822123335125e-06 3090 2213.27272727273 1992 9.89894092380626e-08 304 2.2744362295815 -1.36869961566685 -1 14.3630992485308 3090 2034 1516 1760 977 1992 1806 4320 304 2938 3609 1868 M16078 GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of B cell activation. 34/210 Gene Ontology BP GO:0050871 8.7073886279809e-05 0.000160175932645465 1995 1977.18181818182 1992 7.91612116104934e-06 827 1.3800537438375 -1.1272765385562 -1 6.20485804538357 1992 1898 2103 1894 2397 827 1264 2770 2451 2434 1719 1869 M16367 GO_PHOSPHOLIPID_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_EFFLUX.html The directed movement of a phospholipid out of a cell or organelle. 5/18 Gene Ontology BP GO:0033700 0.000716605579579856 0.00110464797675607 1580 2144 1992 7.16836770113128e-05 1239 2.12158125217247 2.12158125217247 1 7.43115142882295 1580 2452 4553 2239 2876 2162 1594 1501 1239 1992 1396 1870 M16266 GO_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other 398/1247 Gene Ontology BP GO:0055085 4.38675550032422e-08 6.92303568838191e-07 4225 2139.72727272727 1993 3.9879596252684e-09 177 1.59393644670016 1.76346312770391 1 11.6307800505133 4222 1227 234 1156 732 2209 4629 2419 1993 177 4539 1871 M15231 GO_ISOPRENOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 10/33 Gene Ontology BP GO:0008299 1.47664759071377e-05 3.44007765362973e-05 1585 1966.45454545455 1994 1.34241591101499e-06 236 1.32092387530732 -1.42951270106111 -1 6.98432895241345 1585 1814 2235 2893 3036 1842 2056 236 1994 2835 1105 1872 M11888 GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS.html Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. 19/50 Gene Ontology BP GO:0044068 0.000489878311431242 0.000779473954755057 1500 2066.81818181818 1995 4.45443116011235e-05 955 2.49021077806278 2.64795382232032 1 9.16901877222121 1496 4092 1427 2446 2766 1995 2468 2013 955 1449 1628 1873 M10127 GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION.html Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. 14/22 Gene Ontology BP GO:0051900 0.00285120138168954 0.00403109866479432 2915 2099.81818181818 1997 0.00025953665990034 987 1.76810378516729 1.84861099044295 1 5.01550235969381 2915 2027 1293 1402 3113 2696 1717 3917 987 1997 1034 1874 M12612 GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. 16/40 Gene Ontology BP GO:0045822 2.58569522010736e-06 8.51793480301494e-06 1485 2139.90909090909 1997 2.3506347810194e-07 1320 1.15283563783526 -1.1621198047617 -1 6.92348428834798 1483 1494 1984 2047 1320 1997 2721 3051 3501 2256 1685 1875 M14875 GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune effector process. 89/270 Gene Ontology BP GO:0002699 2.23239762852714e-05 4.89377818189401e-05 1750 1938.54545454545 1997 2.0294729832477e-06 901 1.5733538437205 -1.43454686125161 -1 8.03373549421321 1748 2576 1324 1980 1997 901 2158 2010 2940 2149 1541 1876 M11970 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 10/37 Gene Ontology BP GO:0050716 0.000131533374171764 0.000232739884252859 2535 1887.72727272727 1998 1.19582944485409e-05 709 1.51397218086784 1.50675699247614 1 6.5159347303922 2534 709 1632 2174 2495 2063 713 1998 3205 1368 1874 1877 M10700 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 992/2850 Gene Ontology BP GO:0048584 1.79551570395764e-07 1.70831545358101e-06 1825 1968.09090909091 1999 1.7955158490321e-08 130 1.62263284644503 1.8454549086917 1 11.0861506593581 1824 1049 3622 1512 303 3922 2828 1999 2094 130 2366 1878 M12909 GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 45/133 Gene Ontology BP GO:0048259 1.71889179799393e-06 6.39323889408018e-06 3095 1983.54545454545 1999 1.56263012817309e-07 1068 1.3995868348367 -1.28589310220145 -1 8.61198261167702 3093 1083 1687 1218 1156 1999 3188 2807 2256 1068 2264 1879 M16930 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 30/86 Gene Ontology BP GO:0045980 5.07423632698532e-05 9.9449891372701e-05 1380 2131.63636363636 1999 4.61304851505172e-06 1092 1.50512841283773 1.50512841283773 1 7.13627496532251 1378 2190 1999 2821 2249 1595 1386 1891 3123 3724 1092 1880 M10204 GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. 33/70 Gene Ontology BP GO:2000242 2.25651719458755e-05 4.93732767882659e-05 4510 2573.09090909091 2000 2.05140030889351e-06 828 1.80163611520227 -1.77306671472758 -1 9.19116080596126 4507 1396 1357 1175 2000 3891 4478 2931 828 1158 4583 1881 M11083 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. 14/46 Gene Ontology BP GO:0002719 0.000634297741202686 0.000988956532306077 1940 2112 2000 5.7680063088633e-05 1310 1.55023978309836 -1.65122255898521 -1 5.51817809059633 1872 2472 1939 2438 2813 1310 2077 1661 2711 2000 1939 1882 M12500 GO_LYMPHOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. 200/544 Gene Ontology BP GO:0046649 6.16971855418942e-07 3.23818309264637e-06 3090 2080.90909090909 2000 5.60883662221526e-08 664 1.56476124162641 1.94217808822115 1 10.1759417254942 3086 2000 664 936 753 3570 3830 2412 1650 914 3075 1883 M13050 GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 35/104 Gene Ontology BP GO:0010517 2.66905494952919e-06 8.70865926258893e-06 4520 2625.72727272727 2002 2.42641653422754e-07 985 2.32155438123925 -2.51435418706204 -1 13.915909869309 4520 2890 985 1665 1330 4297 4276 2002 1889 1284 3745 1884 M15630 GO_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 937/2497 Gene Ontology BP GO:0051049 1.40634633502177e-07 1.47591794840629e-06 2005 1999.90909090909 2003 1.40634642402323e-08 77 1.62537880560739 1.81427252675786 1 11.2271890775285 2003 494 4433 1305 575 3455 2499 2769 1974 77 2415 1885 M13416 GO_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_URINE_VOLUME.html Any process that modulates the amount of urine excreted from the body over a unit of time. 14/30 Gene Ontology BP GO:0035809 0.00209342868449583 0.00300457167916974 1055 1973.54545454545 2004 0.000190493032919966 875 2.45148737795427 2.19215697303065 1 7.32470580736502 1052 2512 875 1614 3064 1861 1582 2521 2550 2004 2074 1886 M14870 GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 17/24 Gene Ontology BP GO:0090312 0.000119991335678288 0.00021402987766204 1405 2009.09090909091 2005 1.09088982443126e-05 623 2.39696956142688 2.79089953052212 1 10.4195862051579 1404 3739 2005 3656 2472 2048 1301 677 623 2330 1845 1887 M11933 GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. 8/17 Gene Ontology BP GO:0003161 5.49352826951626e-06 1.5110457201045e-05 2715 2349.36363636364 2006 5.49354185004729e-07 611 1.9090864986913 2.11473224302656 1 10.9022406443375 2714 1819 3828 2006 1608 3323 3751 3236 611 1735 1212 1888 M16772 GO_MALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DIFFERENTIATION.html The establishment of the sex of a male organism by physical differentiation. 97/273 Gene Ontology BP GO:0046661 2.29123493774694e-07 1.93916799831772e-06 4155 2329.45454545455 2009 2.08294106942938e-08 345 1.58447078898392 -1.75848524486829 -1 10.7220963997969 4151 1068 1037 1588 345 4571 3567 2009 2032 1273 3983 1889 M15299 GO_RETINA_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_HOMEOSTASIS.html A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. 36/134 Gene Ontology BP GO:0001895 1.71335074845611e-05 3.90913391895907e-05 3570 2499.27272727273 2012 1.55760372009561e-06 566 3.36999228263381 4.01828122382915 1 17.5970803171431 3566 1476 1242 1785 1915 4467 3721 2012 566 2956 3786 1890 M12245 GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myeloid cell differentiation. 119/290 Gene Ontology BP GO:0045637 4.49489678917215e-07 2.76055632170983e-06 4375 2309.36363636364 2013 4.0862706432186e-08 605 1.62474513801554 -1.65078377714717 -1 10.6994195637608 4371 1735 775 1654 605 2764 3860 3124 2013 653 3849 1891 M14163 GO_RESPONSE_TO_PROGESTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROGESTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. 29/72 Gene Ontology BP GO:0032570 5.3050369967784e-05 0.000103405905860798 2985 1940.72727272727 2014 4.82287720520218e-06 799 1.49106988666749 -2.03143008969702 -1 7.03969542614885 2984 799 1239 1685 2261 2176 2872 1392 2014 1167 2759 1892 M11448 GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. 28/68 Gene Ontology BP GO:0003254 0.00172775818654161 0.00251000665210034 2155 1866.27272727273 2015 0.000157192415082262 852 1.8422511675527 2.00718747495547 1 5.67485103907944 2151 2015 957 1012 3029 2544 2369 2927 1133 852 1540 1893 M12878 GO_ORGANIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. 472/1183 Gene Ontology BP GO:0006082 1.46554849350821e-06 5.76656072488019e-06 4270 2231 2015 1.33231769981506e-07 362 1.55675157531335 -1.38942473268212 -1 9.66167955969884 4268 362 606 2386 1087 1648 3970 3403 2015 1576 3220 1894 M15494 GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 39/90 Gene Ontology BP GO:0046889 3.79189085218513e-06 1.1305000062821e-05 4120 2630 2015 3.44717944350339e-07 892 1.87729477065902 2.06650682247987 1 11.0009112815711 4116 1750 892 972 1463 4007 4476 3539 1154 2015 4546 1895 M13721 GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. 97/242 Gene Ontology BP GO:0045017 2.83204305280224e-06 9.07736341705951e-06 1930 1897.81818181818 2016 2.57458790770547e-07 777 1.42810281422697 -1.33577920882233 -1 8.5298972867451 1929 2490 2399 2570 1356 777 2775 793 2335 2016 1436 1896 M15424 GO_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 139/358 Gene Ontology BP GO:0009636 4.06355071561666e-06 1.19411809953216e-05 2020 2198 2016 3.69414383753874e-07 466 1.81314555998929 1.97857379922205 1 10.5739284689281 2016 2535 466 2361 1487 4132 3624 1663 1950 1155 2789 1897 M15749 GO_LIPID_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_LOCALIZATION.html Any process in which a lipid is transported to, or maintained in, a specific location. 118/373 Gene Ontology BP GO:0010876 6.10353982826155e-07 3.23212152206309e-06 4460 2204.72727272727 2016 5.54867411053584e-08 239 1.70058063906471 1.73023029380444 1 11.0608406669907 4459 239 403 1197 742 2918 4187 3135 2016 500 4456 1898 M11017 GO_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 19/43 Gene Ontology BP GO:0060996 7.19403298476184e-07 3.54208856291084e-06 2210 2101.18181818182 2018 6.54003212474772e-08 763 1.44262209564305 -1.13854508614285 -1 9.31506985770228 2208 1560 1916 1190 819 2556 2279 4522 763 2018 3282 1899 M14848 GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING.html Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 7/17 Gene Ontology BP GO:0090036 4.79787150436091e-07 2.85282200842265e-06 4560 2404.27272727273 2018 4.79787254024192e-08 175 1.47831714780662 1.41133000899546 1 9.71014416380294 4557 175 4304 644 685 4019 3977 2018 593 924 4551 1900 M12376 GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. 12/52 Gene Ontology BP GO:0061098 7.65721499435094e-05 0.000143010656551776 1080 1717.63636363636 2019 6.96134683700779e-06 257 1.85866881882142 1.85866881882142 1 8.46515198200342 1078 3012 2019 1410 3156 2151 2066 428 257 2348 969 1901 M16638 GO_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. 37/88 Gene Ontology BP GO:0055072 4.11630280689682e-07 2.61980478260637e-06 2265 2062.81818181818 2020 3.74209416097864e-08 570 1.45808309945217 -1.39352953682664 -1 9.64115822152141 2264 1393 2526 2614 570 1745 1363 3475 2020 1866 2855 1902 M10476 GO_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of a cytokine. 305/853 Gene Ontology BP GO:0001817 7.13442431498678e-07 3.52813579543009e-06 3730 2212.27272727273 2021 6.48584238965879e-08 447 1.58580261796096 -1.41691324288006 -1 10.2428126109059 3728 1881 447 1486 813 2021 3671 3956 2523 652 3157 1903 M13516 GO_PIGMENT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. 19/41 Gene Ontology BP GO:0050931 1.27628825801536e-05 3.04355746377263e-05 1010 2558.18181818182 2022 1.16026878383606e-06 820 1.53969319769191 -1.24326694124982 -1 8.23807255489086 4360 820 1095 1008 1823 3573 3940 4286 1007 2022 4206 1904 M15085 GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. 59/158 Gene Ontology BP GO:0043467 0.000193501569648293 0.000331400880810411 940 2101.90909090909 2022 1.75925992022712e-05 549 1.27406485623754 1.39390139323896 1 5.25175678272349 938 2720 2213 2022 2951 1884 1872 549 3058 3521 1393 1905 M14462 GO_CELLULAR_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 6/28 Gene Ontology BP GO:0071467 2.64936286914453e-06 8.66877505386756e-06 3350 1836 2023 2.64936602775546e-07 180 1.84635846022511 -1.87920016526763 -1 11.0718405698035 3346 180 4239 788 1365 2023 3071 2202 301 461 2220 1906 M12864 GO_BONE_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MINERALIZATION.html The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. 16/53 Gene Ontology BP GO:0030282 0.00014280477397879 0.000250299194255764 1880 2131.18181818182 2024 1.29830949508367e-05 803 2.59574526179856 2.26507355292659 1 11.074609315803 1880 2024 803 1912 2514 3123 2619 3202 1416 1148 2802 1907 M14708 GO_GLUTATHIONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. 34/71 Gene Ontology BP GO:0006749 2.50588741738862e-05 5.39899548906514e-05 1025 1992.09090909091 2024 2.27810541899745e-06 1021 1.27134695333809 -1.35915375668513 -1 6.42738978509529 1021 2095 2180 3288 2024 1307 1628 1808 2796 2433 1333 1908 M14045 GO_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 155/420 Gene Ontology BP GO:0006631 6.04726085024251e-07 3.23212152206309e-06 2265 1916.18181818182 2027 5.49751137498815e-08 739 1.46960495912896 -1.28115223996647 -1 9.55853873347932 2164 874 1269 2027 739 894 1892 3599 2261 3096 2263 1909 M15792 GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that activates or increases the activity of a monooxygenase. 19/35 Gene Ontology BP GO:0032770 1.37800725734276e-05 3.23462471983944e-05 3245 2290.54545454545 2027 1.25274171709115e-06 288 2.37487636310894 2.7638251573849 1 12.6322997568046 3244 1849 972 1370 1856 4531 3598 2060 288 2027 3401 1910 M10536 GO_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CHEMOTAXIS.html The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). 82/236 Gene Ontology BP GO:0060326 1.59716369827549e-06 6.08798146965442e-06 835 1719.90909090909 2029 1.45196805253742e-07 421 1.96253656815468 2.03140438164927 1 12.1253412602364 835 2830 421 2291 1120 2029 1491 2527 2564 743 2068 1911 M11150 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. 60/110 Gene Ontology BP GO:0048010 7.06971369480235e-07 3.50691032959052e-06 2030 1881.36363636364 2030 6.4270145151457e-08 811 1.73466619329917 2.02888110510123 1 11.2097184328345 2030 2090 1136 1217 811 3067 2251 1697 1316 2042 3038 1912 M16109 GO_FEMALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. 11/23 Gene Ontology BP GO:0030540 2.56912380407059e-05 5.51658371305308e-05 4495 2441.90909090909 2032 2.33559436942381e-06 84 2.99996891395501 -1.87449985558331 -1 15.1333159875094 4495 1430 1047 399 2032 4159 4301 3033 84 1547 4334 1913 M16176 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition. 25/44 Gene Ontology BP GO:1902808 0.00019740835479322 0.000336973158567986 1560 2165.45454545455 2032 1.79478246074333e-05 552 1.52068010515016 1.79814005782924 1 6.25527177456361 1556 3546 2129 3260 3184 1774 1183 552 1538 3066 2032 1914 M16320 GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 11/23 Gene Ontology BP GO:0046325 2.57153041218049e-05 5.51736269680782e-05 3610 2380 2033 2.33778224610158e-06 774 1.91452557475616 1.61002533920663 1 9.65766721985459 3610 1202 774 843 2033 4562 3201 3212 1180 991 4572 1915 M16700 GO_RESPONSE_TO_MONOAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MONOAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. 16/70 Gene Ontology BP GO:0071867 3.07741615364876e-05 6.39590116445442e-05 400 1649.90909090909 2033 2.79769018379495e-06 176 1.33959676582297 1.33959676582297 1 6.65565317468346 396 2274 2033 2107 2759 176 528 823 3995 2856 202 1916 M13869 GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 53/131 Gene Ontology BP GO:0042345 1.35570730542453e-05 3.19196197722418e-05 1935 2064.54545454545 2034 1.23246878161798e-06 1325 1.58299086238416 -1.52899546558457 -1 8.43096237238812 2081 2185 2583 1935 1851 1396 2034 2503 1325 2885 1932 1917 M16361 GO_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 243/581 Gene Ontology BP GO:0006979 8.35431214907298e-07 3.89057886741683e-06 1625 1912 2035 7.59483211050305e-08 574 1.6002388344638 1.84269690637433 1 10.2555500718525 1624 2047 574 2258 880 3268 3116 1653 2532 1045 2035 1918 M10438 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 7/40 Gene Ontology BP GO:0046189 2.36972217839839e-05 5.15345202543501e-05 1205 2018.63636363636 2036 2.36974744890207e-06 1127 1.76533562318528 -1.76533562318528 -1 8.96706116664236 1205 1127 3584 2237 2036 1821 2394 1465 2649 2372 1315 1919 M11912 GO_FOREBRAIN_GENERATION_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_GENERATION_OF_NEURONS.html The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. 24/114 Gene Ontology BP GO:0021872 0.00854723303970011 0.0114497412011909 2040 2009.18181818182 2037 0.000780056517548295 1181 1.82432886955002 -1.7198300979376 -1 4.19519651882588 1861 1181 1323 2327 3438 1391 2257 1266 2980 2037 2040 1920 M11533 GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. 9/36 Gene Ontology BP GO:1903306 7.85000336451618e-05 0.000146023900726958 2740 2217.36363636364 2038 7.85028067979118e-06 1194 1.6015677544741 -1.89475939403466 -1 7.27702582579725 2739 1864 3763 2038 2391 1929 3214 1726 1456 1194 2077 1921 M11535 GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. 12/36 Gene Ontology BP GO:1902932 0.00133669938861834 0.00197087813952206 975 1962.09090909091 2038 0.000121592022378741 952 2.02079252724825 -2.10516438616899 -1 6.47622019376927 2993 2475 974 1626 2973 2223 2011 952 975 2343 2038 1922 M12542 GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of glial cell proliferation. 13/29 Gene Ontology BP GO:0060251 2.61784653771677e-05 5.60639366910468e-05 4310 2315.27272727273 2038 2.37988880798493e-06 619 1.45601577819423 -1.2372946280393 -1 7.33276070287585 4310 838 2414 884 2038 3182 3172 1875 619 1842 4294 1923 M12778 GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT.html The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. 241/630 Gene Ontology BP GO:0061458 2.28158325449912e-07 1.93916799831772e-06 2930 2228.09090909091 2038 2.07416681010759e-08 344 1.68746374619493 1.56917997941854 1 11.4190487176314 2930 1230 432 1290 344 4052 3269 4074 2038 732 4118 1924 M10270 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 7/25 Gene Ontology BP GO:0044550 1.11027446337617e-05 2.69754282232106e-05 2705 2213.81818181818 2039 1.1102800106074e-06 553 1.85392572070733 -2.2180045032669 -1 10.0344719963114 2704 1445 3560 2039 1807 3321 4372 553 564 1492 2495 1925 M10495 GO_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WOUND_HEALING.html Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 76/209 Gene Ontology BP GO:0061041 6.51276095597272e-08 9.30052152404199e-07 2305 2008.72727272727 2039 5.92069195342997e-09 245 1.87659395507107 1.85487369050116 1 13.4082829640803 2305 884 245 636 1459 3658 2968 4204 2039 257 3441 1926 M12487 GO_LIPOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOXYGENASE_PATHWAY.html The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. 6/15 Gene Ontology BP GO:0019372 0.000142011343796618 0.000249096588306647 2040 2031.36363636364 2040 1.42020419862729e-05 834 2.55483564357547 -3.19379569295086 -1 10.9064010271942 2040 1994 3917 2806 2541 996 834 1259 2123 2182 1653 1927 M15573 GO_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. 24/132 Gene Ontology BP GO:0009620 0.000304837986408865 0.000501723775574747 1840 2240.81818181818 2040 2.77163848895871e-05 1226 2.457556232954 2.28402265740463 1 9.60581616789433 1837 2948 1448 2329 2672 2880 2032 3577 1660 2040 1226 1928 M11058 GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a type 2 immune response. 14/45 Gene Ontology BP GO:0002828 1.97202637514926e-06 7.0867789936672e-06 2045 1985 2041 1.79275285711623e-07 1203 1.96668782968148 -2.02432504068984 -1 11.9972813607804 2041 2106 1316 1962 1203 2262 2898 2119 1516 1999 2413 1929 M11917 GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. 6/26 Gene Ontology BP GO:0051156 0.000832970326833568 0.00126719568397387 700 2056.27272727273 2042 8.33282719452642e-05 389 0.751494248885936 -0.751494248885936 -1 2.57914291485863 696 2042 3822 2435 2992 389 474 935 3687 4294 853 1930 M11813 GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. 5/23 Gene Ontology BP GO:0016056 0.000615699878131593 0.000963172012858823 910 2215.18181818182 2044 6.15870533534242e-05 665 1.18944892673502 1.18944892673502 1 4.2500858987205 906 2044 3810 3151 2832 987 665 1753 3957 2980 1282 1931 M16450 GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. 12/19 Gene Ontology BP GO:1900119 0.000141436802705706 0.000248276398851642 2045 1752.63636363636 2044 1.28587178562974e-05 509 2.62110827893821 3.39047390602481 1 11.1937613984425 2044 2318 1566 2414 2550 2268 849 509 913 2367 1481 1932 M13737 GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. 2/18 Gene Ontology BP GO:0021892 5.82371604191215e-05 0.000112104119330838 2040 2041 2046.5 6.47096309304907e-06 276 1.69379145427173 -1.69379145427173 -1 7.92641210229426 2038 2745 4125 NA 3424 1742 2055 418 276 2293 1294 1933 M14526 GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 71/175 Gene Ontology BP GO:0090263 0.00881406357782145 0.0117833853129355 2030 2479.18181818182 2047 0.000804506865581293 1275 1.93432632082637 1.99338755944228 1 4.41956062462598 1700 3569 2207 2026 3476 3988 3535 1275 1422 2047 2026 1934 M14794 GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. 21/54 Gene Ontology BP GO:0048169 3.32248133540054e-07 2.38427833698064e-06 2050 1761.45454545455 2047 3.02043803378911e-08 469 1.30635902217631 1.44137118529729 1 8.70123864415218 2047 2021 2279 780 469 2118 1131 2312 1508 2220 2491 1935 M12955 GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. 86/264 Gene Ontology BP GO:1903707 1.21544683823448e-05 2.92399982897548e-05 1250 2329.81818181818 2048 1.10495777576045e-06 623 1.44613259435974 -1.34479364930386 -1 7.76729515328419 1250 3568 2048 4228 1804 623 1882 2436 3233 3030 1526 1936 M10087 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 61/165 Gene Ontology BP GO:0051928 3.48411019054701e-06 1.06245525606245e-05 1540 1899.09090909091 2049 3.16737791663395e-07 800 1.71154445572442 1.76199030428818 1 10.0842793924659 1538 3142 1021 2449 1427 2159 2049 1543 2687 800 2075 1937 M11295 GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 12/29 Gene Ontology BP GO:0010832 2.67221576877645e-05 5.6965554703531e-05 3870 2479.81818181818 2049 2.42931657020399e-06 1110 1.72422416571308 -1.95086606604532 -1 8.66935504042871 3866 1936 1152 2397 2049 3351 4010 1865 1996 1110 3546 1938 M11515 GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein oligomerization. 10/25 Gene Ontology BP GO:0032461 5.3590086194093e-06 1.48194621917316e-05 1580 2273.09090909091 2049 4.87183788502967e-07 410 2.11202010893668 -1.07364058415015 -1 12.0822652097418 4015 1289 1576 2049 1579 2964 4199 573 410 2812 3538 1939 M12370 GO_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_SIGNAL_TRANSDUCTION.html The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. 826/2025 Gene Ontology BP GO:0035556 1.86255005268785e-07 1.73572332354834e-06 2000 1911.54545454545 2049 1.86255020879704e-08 309 1.53008941643954 1.62947232825763 1 10.4413461587127 1996 495 3897 818 309 3637 2352 2468 2049 464 2542 1940 M15667 GO_MECHANOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of a mechanical stimulus. 8/22 Gene Ontology BP GO:0007638 8.22902891988372e-06 2.10393068695045e-05 2985 2177.90909090909 2050 8.22905939265517e-07 68 1.63882822548199 -0.62003503935512 -1 9.07979217067342 2982 1297 4437 703 1728 3936 3910 306 68 2540 2050 1941 M11754 GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. 36/91 Gene Ontology BP GO:1904063 4.18099569605448e-07 2.64473610582847e-06 2150 1944 2052 3.80090590057555e-08 578 1.31394883878468 -1.07463345889537 -1 8.68170876820831 2148 793 2052 1247 578 2276 2047 4358 2483 837 2565 1942 M13074 GO_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_B_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. 31/57 Gene Ontology BP GO:0043491 4.71598565211166e-06 1.33960977678131e-05 1125 2077.18181818182 2052 4.28726887406325e-07 1122 1.67388454649239 1.65633669380506 1 9.66277507958321 1122 3790 1795 1193 1537 2046 2052 2435 2175 2633 2071 1943 M10076 GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that activates or increases the frequency, rate or extent of protein maturation. 10/42 Gene Ontology BP GO:1903319 0.0023734208255304 0.00338445727670075 3270 2274.81818181818 2053 0.000215998655592426 223 2.64429359958245 -1.81446701375094 -1 7.73881503376111 3270 1769 1267 1838 3083 3252 2755 1617 223 2053 3896 1944 M15437 GO_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. 63/149 Gene Ontology BP GO:0050673 1.07952962767894e-06 4.63668460806044e-06 4450 2712.36363636364 2053 9.81391052181277e-08 975 1.76090096627921 -1.61772391522563 -1 11.1262568037923 4448 2053 979 1556 975 3779 4575 4258 1667 1870 3676 1945 M14701 GO_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGING.html An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). 53/113 Gene Ontology BP GO:0007569 2.70252098961834e-05 5.7479637905625e-05 2680 2171.72727272727 2054 2.45686744405513e-06 792 1.61020671384011 1.95526839072975 1 8.08863569825821 2676 1320 2000 1706 2054 4093 2897 792 1066 2572 2713 1946 M14731 GO_BEHAVIORAL_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_COCAINE.html Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. 5/15 Gene Ontology BP GO:0048148 4.19044364889674e-06 1.22135780676884e-05 1040 2050.90909090909 2055 4.19045155083581e-07 142 2.09756496296649 2.09756496296649 1 12.2082696134644 1038 3753 4283 2055 3860 929 476 142 2081 2997 946 1947 M16724 GO_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_SELECTION.html The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. 21/47 Gene Ontology BP GO:0045058 1.06295232581281e-06 4.58243978528215e-06 3420 2311.81818181818 2058 9.66320763081237e-08 687 1.25483126303805 -0.885796282154888 -1 7.93625089878481 3418 687 2062 935 971 4325 4485 2058 1210 1693 3586 1948 M11239 GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. 91/245 Gene Ontology BP GO:0022408 7.29955002786812e-06 1.90510459693039e-05 3675 2632.09090909091 2060 6.63597658883802e-07 372 1.97610742179089 -1.83531634712004 -1 11.0493836321565 3672 1884 372 1822 2060 4108 4512 4260 1644 485 4134 1949 M12750 GO_ATP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 20/46 Gene Ontology BP GO:0006754 0.0112874848888987 0.0148506070669189 1550 2433.36363636364 2060 0.00103143788470897 1425 1.23049181022975 -1.30651841478347 -1 2.66497729489321 1547 3768 3161 3183 3315 1615 1550 1471 1425 3672 2060 1950 M12236 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION.html A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. 10/31 Gene Ontology BP GO:0072378 0.00822246743130708 0.0110274166041475 1595 2113.45454545455 2062 0.000750305504597327 1400 1.61287052619089 1.60472177328784 1 3.74011537454509 1595 2607 1543 2352 3276 2093 1694 1400 2631 2062 1995 1951 M13556 GO_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSPORT.html The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 165/504 Gene Ontology BP GO:0015711 4.66867844995793e-08 7.17770663680617e-07 2160 2113.36363636364 2062 4.24425322639381e-09 238 1.78101369819284 1.92068202807226 1 12.962761261634 2157 1149 238 1558 1429 4437 3130 3532 2062 397 3158 1952 M11843 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). 255/684 Gene Ontology BP GO:0032787 7.1672447111362e-07 3.53667743070534e-06 2065 1995.27272727273 2064 6.51567913282714e-08 369 1.56362310701564 -1.37881732107193 -1 10.0976083352402 3192 369 742 2064 815 1194 2913 3670 2064 2150 2775 1953 M13919 GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 137/336 Gene Ontology BP GO:0006650 3.46743962794529e-07 2.45791178512213e-06 3650 2345.63636363636 2065 3.1522183404106e-08 481 1.57901542627446 -1.39687193473556 -1 10.492607439212 3647 2683 1698 1572 481 2065 4430 3294 1653 1260 3019 1954 M14196 GO_SEGMENT_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENT_SPECIFICATION.html The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. 14/24 Gene Ontology BP GO:0007379 0.000125083236296842 0.000222258502153171 2320 1943.36363636364 2065 1.13718498725021e-05 483 2.26887990026144 3.01744062377424 1 9.81874640419761 2319 1567 876 2066 3096 2734 2384 483 1781 2006 2065 1955 M15337 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. 11/42 Gene Ontology BP GO:0032743 2.79138018141445e-05 5.91051683541135e-05 2415 2137.90909090909 2065 2.53765054484672e-06 743 1.35798741840079 -1.33929115306196 -1 6.80216543034362 2415 2704 2044 2210 2065 1865 3723 1579 2625 1544 743 1956 M13245 GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. 10/23 Gene Ontology BP GO:2000310 0.00161001394573022 0.00234998263125603 2470 1926.72727272727 2066 0.000146472127455325 700 1.46593698423963 -1.12659342044625 -1 4.56534023657671 2467 1017 1439 963 3017 2240 2675 2861 700 2066 1749 1957 M15296 GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 13/51 Gene Ontology BP GO:0035249 8.66485555564165e-05 0.000159583198511877 1020 1771.81818181818 2066 7.87745167811206e-06 336 1.32986594010646 1.15948939254812 1 5.98174517462517 1019 2066 2233 2628 2393 1058 336 2229 2427 1854 1247 1958 M15523 GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. 229/638 Gene Ontology BP GO:0002683 7.96366285982134e-07 3.78457386470322e-06 3530 2241.63636363636 2066 7.23969612958791e-08 522 1.63726635499821 -1.46474454527472 -1 10.5161197352669 3530 1731 522 1917 859 2066 3484 4301 2210 642 3396 1959 M11095 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. 5/24 Gene Ontology BP GO:0048172 0.000331991478441402 0.000541234703091092 2370 2269.63636363636 2068 3.32041087126295e-05 796 1.38407756610769 -1.60505206789347 -1 5.35594689488346 2369 1728 3688 2608 2713 1943 2068 796 3101 1963 1989 1960 M13369 GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 10/20 Gene Ontology BP GO:0050857 0.00303881431811912 0.00427811245573896 2055 2088.72727272727 2068 0.000276638173110169 1062 1.82927652419711 1.70495928795975 1 5.13305768593629 2051 2641 1491 2538 3125 2413 1175 3022 1390 2068 1062 1961 M12177 GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of leukocyte differentiation. 132/409 Gene Ontology BP GO:1902105 5.46088434426684e-06 1.50384851781915e-05 2070 2170.54545454545 2069 4.96445263584649e-07 1261 1.57128765278251 -1.71870396074797 -1 8.97702845655244 2069 3652 1438 2782 1586 1571 2532 1984 2723 1261 2278 1962 M14536 GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/28 Gene Ontology BP GO:0010829 2.80009123316868e-05 5.92292646724473e-05 3735 2636.54545454545 2069 2.54556988408155e-06 898 1.91452557475616 1.61002533920663 1 9.58780252583609 3732 1501 898 1336 2069 4637 4055 3406 1531 1255 4582 1963 M14380 GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 103/383 Gene Ontology BP GO:0071383 3.93023928683802e-05 7.93395696034301e-05 2080 1925.36363636364 2071 3.57300863748579e-06 624 1.94230829306715 2.11331555432768 1 9.43483003699269 2078 3170 624 1242 2178 2723 2071 2528 1642 1105 1818 1964 M11249 GO_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 29/78 Gene Ontology BP GO:0006801 1.90485208253896e-06 6.87197219831268e-06 3045 2042.72727272727 2072 1.73168521076511e-07 1194 1.55917679084757 -1.94539581479494 -1 9.53605319319634 3045 2630 1857 2109 1194 1290 2072 1417 2781 2459 1616 1965 M12254 GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 15/26 Gene Ontology BP GO:0050860 2.81169880889e-05 5.94206534805474e-05 3920 2691.18181818182 2072 2.55612249482416e-06 1133 2.12210698419999 -2.14538677678411 -1 10.6238328983114 3917 1269 1133 1991 2072 4222 3762 3271 1915 1472 4579 1966 M13624 GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 10/24 Gene Ontology BP GO:0051043 0.00168761005178346 0.00245475359349329 2560 2041.63636363636 2072 0.000153536909254638 377 1.95043586941541 -1.56398417590496 -1 6.0304378760452 2560 3098 1882 2709 3026 1362 1873 2082 377 2072 1417 1967 M14064 GO_RETINA_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_LAYER_FORMATION.html The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. 10/38 Gene Ontology BP GO:0010842 0.000761551252532007 0.00116850048430473 1900 2165.54545454545 2073 6.92559089710256e-05 1038 1.27882559197445 1.42374946738546 1 4.44230309926535 1898 2167 2353 3387 2869 1529 1038 2066 2698 2073 1743 1968 M14310 GO_RHYTHMIC_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_BEHAVIOR.html The specific behavior of an organism that recur with measured regularity. 10/32 Gene Ontology BP GO:0007622 3.79487965586179e-06 1.1305000062821e-05 3735 2210.72727272727 2073 3.44989654712492e-07 113 2.34356737168188 -0.990902152196439 -1 13.7332601812732 3731 1023 1590 2073 1464 4603 4048 619 113 2076 2978 1969 M10344 GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. 9/23 Gene Ontology BP GO:0046337 1.52862766001891e-05 3.54339402170134e-05 4355 2800.90909090909 2074 1.52863817528206e-06 646 2.12569263092483 -2.59414721370331 -1 11.2071496024761 4351 2074 3569 1902 1908 4355 4527 1727 646 1190 4561 1970 M10807 GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 11/27 Gene Ontology BP GO:0009065 2.82283014255314e-06 9.0576367324632e-06 3780 2207.36363636364 2076 2.56621251322365e-07 325 1.47430065761788 -1.68530500658125 -1 8.80748197591796 3778 325 1378 912 1354 3727 3342 3069 2076 664 3656 1971 M11029 GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 49/108 Gene Ontology BP GO:0071322 3.96867934741654e-06 1.16994147365428e-05 1035 2152.63636363636 2076 3.60789682428592e-07 1034 1.2916847282607 1.37961075182822 1 7.54645773671524 1034 2426 2076 3394 1481 1452 1930 2890 2935 2664 1397 1972 M11802 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 885/2327 Gene Ontology BP GO:0010628 4.85512983973752e-07 2.86654203278225e-06 2080 2365.54545454545 2077 4.85513090049071e-08 678 1.65885429930319 1.85642815041892 1 10.8918858466156 2077 3648 3808 3245 691 3953 2782 1583 2000 678 1556 1973 M12384 GO_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that modulates the frequency, rate, or extent of a homeostatic process. 262/664 Gene Ontology BP GO:0032844 0.000928019666380866 0.00140123424748174 1560 2057.36363636364 2078 8.44010328712082e-05 619 1.59002428488537 1.73146822106849 1 5.37474624577437 1558 3515 619 2602 3112 2078 1949 2266 2866 1130 936 1974 M14374 GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY.html Any process that activates or increases the activity of a cyclase. 22/72 Gene Ontology BP GO:0031281 6.20276072953408e-06 1.66759803516078e-05 2110 2030.27272727273 2078 5.63888928899483e-07 446 1.22770226349655 1.50449678387692 1 6.94878529494778 2109 446 1288 1315 1621 2039 2078 3140 3700 2306 2291 1975 M15447 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 64/136 Gene Ontology BP GO:0072329 9.70622495450996e-06 2.41252689848981e-05 1695 1987 2078 8.82387979806062e-07 1023 1.57065874902551 -1.62573336424408 -1 8.59150756081846 1695 2493 2161 2744 1752 1402 2119 1023 1824 2566 2078 1976 M12473 GO_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BUDDING.html The evagination of a membrane, resulting in formation of a vesicle. 82/170 Gene Ontology BP GO:0006900 1.48502222897623e-06 5.82344443339241e-06 2270 2108.81818181818 2080 1.35002111943835e-07 1078 1.52057935337193 -1.21671840050887 -1 9.42950449359922 2270 1316 2391 2958 1091 1078 2080 4160 1657 2316 1880 1977 M11183 GO_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE.html Any process that modulates the frequency, rate or extent of a defense response. 435/1123 Gene Ontology BP GO:0031347 4.10590635661287e-07 2.61980478260637e-06 4565 2505.36363636364 2081 3.73264283900639e-08 569 1.55440947863293 -1.3777543583763 -1 10.2780890143769 4561 1597 1081 2081 569 2004 3943 4313 2405 1462 3543 1978 M10390 GO_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 22/68 Gene Ontology BP GO:0010043 2.15148117338645e-05 4.7387699658602e-05 4175 2380.63636363636 2082 1.95591110363485e-06 295 2.61678754411205 2.50727964174717 1 13.4049679146669 3993 1553 405 943 2082 3564 4172 4600 295 407 4173 1979 M10777 GO_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MATURATION.html Any process leading to the attainment of the full functional capacity of a protein. 145/391 Gene Ontology BP GO:0051604 6.12455171914403e-07 3.23212152206309e-06 3960 2256.27272727273 2082 5.56777584013707e-08 694 1.72801756572556 -1.43859153819305 -1 11.239294727538 3958 1461 1306 2082 746 2622 3490 2287 1546 694 4627 1980 M11915 GO_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. 39/112 Gene Ontology BP GO:0031016 1.37171579568921e-05 3.22311560697621e-05 3275 2283.36363636364 2082 1.2470221350094e-06 1342 1.59146160457231 -1.49527492258246 -1 8.46812489360494 3275 2216 1707 1342 1854 1941 3154 2729 2082 2014 2803 1981 M15992 GO_NEUTRAL_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSPORT.html The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/38 Gene Ontology BP GO:0015804 2.39557011293737e-06 8.07157622232818e-06 3325 2278.36363636364 2082 2.17779338315171e-07 1006 1.84427387906386 2.03607809154565 1 11.1270663794164 3325 2105 1292 1715 1287 4538 3990 2700 1006 1022 2082 1982 M11648 GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 7/13 Gene Ontology BP GO:0032352 0.00021072592027962 0.000358651190563885 2630 2214.90909090909 2084 2.10745905382944e-05 434 1.70722983735684 -1.56553565533375 -1 6.96787783783544 2628 1773 3781 733 2622 2977 3966 1870 434 1496 2084 1983 M14049 GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. 835/2035 Gene Ontology BP GO:0051247 2.6533832882758e-07 2.08102341342307e-06 1720 2072.81818181818 2084 2.65338360509579e-08 403 1.55179057254964 1.7188603973579 1 10.4445852794113 1719 2084 4176 1841 427 3419 2573 2164 2255 403 1740 1984 M14600 GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS.html Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. 26/64 Gene Ontology BP GO:0097006 7.35539863208196e-05 0.000137817255241148 2050 2309.63636363636 2084 6.68694960115517e-06 1277 1.5279504904296 1.60703770636876 1 6.98800054834671 2050 1688 1701 2084 2356 3359 2717 3409 2889 1277 1876 1985 M14762 GO_RHYTHMIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_PROCESS.html Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. 152/434 Gene Ontology BP GO:0048511 6.85995519783869e-07 3.45538332145383e-06 2590 2258.90909090909 2085 6.23632485171311e-08 523 1.70960509451673 1.89373643435798 1 11.0607882077935 2587 2534 523 1696 799 4611 3498 3736 2085 731 2048 1986 M14837 GO_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATPASE_ACTIVITY.html Any process that modulates the rate of ATP hydrolysis by an ATPase. 51/124 Gene Ontology BP GO:0043462 9.53622603502999e-08 1.19991050083047e-06 2765 2090.27272727273 2086 8.66929677126535e-09 110 1.65510206707063 1.62350800488697 1 11.6087902032584 2297 2620 1252 2009 110 2762 1759 3818 1519 2761 2086 1987 M16967 GO_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 12/40 Gene Ontology BP GO:0071731 0.0339893982621133 0.0427213795698408 1060 2557.45454545455 2087 0.00313874290084204 823 2.44289800522702 2.44289800522702 1 3.96277321579874 1060 4133 1042 4016 4043 1202 823 2087 4188 3709 1829 1988 M14063 GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of smoothened signaling. 27/92 Gene Ontology BP GO:0008589 0.000759058525115195 0.00116535669441648 920 1911.63636363636 2088 6.90291406431076e-05 738 1.37140163617371 1.19958304821867 1 4.76578880276075 916 2545 2178 2083 2866 1289 738 2600 2088 1408 2317 1989 M16762 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of macrophage differentiation. 10/17 Gene Ontology BP GO:0045651 0.00103028402477206 0.00154111105896156 3140 2074.81818181818 2088 9.37060758735231e-05 1018 1.68229405688518 -1.71705322561525 -1 5.60429315771733 3140 2235 1018 1606 2932 2088 1434 1914 2635 1381 2440 1990 M13361 GO_CELLULAR_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. 81/197 Gene Ontology BP GO:0044242 1.56476910969508e-06 6.02923068573796e-06 1540 2236.18181818182 2089 1.42251838422891e-07 1107 1.5360536244096 -1.49069851284373 -1 9.49802077003458 1539 3240 2196 3859 1107 1331 1837 1539 2791 3070 2089 1991 M13644 GO_OUTER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 15/61 Gene Ontology BP GO:0036158 5.16676055346516e-06 1.44166281548911e-05 3360 2230.63636363636 2089 4.69706607980403e-07 420 1.5588617097289 -2.38473176863456 -1 8.93990533451425 3357 2666 2089 1296 1570 3335 4472 420 846 2722 1764 1992 M15232 GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. 590/1532 Gene Ontology BP GO:0051248 2.187261546403e-07 1.89821595513068e-06 1985 2197.09090909091 2089 2.18726176168812e-08 365 1.63369528831896 1.85037365356738 1 11.0731380080855 1985 3757 4373 2511 365 2714 2116 1362 2089 1718 1178 1993 M11253 GO_PHOTOTRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION.html The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. 15/64 Gene Ontology BP GO:0007602 2.93027729245189e-05 6.13956564478978e-05 4425 2534 2090 2.6639239298535e-06 1014 1.35243297520841 -1.65918526769109 -1 6.74788875606064 4423 1267 1487 1983 2090 3887 4316 1776 2443 1014 3188 1994 M12466 GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. 21/50 Gene Ontology BP GO:0001953 0.00466271359078495 0.00644314857202814 1045 2054.45454545455 2090 0.000424784112665274 1017 1.32613009073448 1.14776974165327 1 3.44181039530868 1044 1929 1862 2090 3193 1710 1017 2549 2725 2218 2262 1995 M10753 GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. 20/36 Gene Ontology BP GO:0045932 2.3182931605778e-07 1.94997013488455e-06 2710 1941.36363636364 2091 2.10753945897502e-08 139 1.42754738444459 -1.02838311652402 -1 9.65611746698986 2710 139 1442 1743 351 3141 2091 2958 2838 1571 2371 1996 M10714 GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. 25/77 Gene Ontology BP GO:0002286 3.87305179433058e-07 2.57804519639595e-06 4585 2587 2093 3.52095679652094e-08 525 1.43766319945225 1.48321315669919 1 9.51802222466328 4585 1552 1735 1656 525 2865 3863 3836 2093 1185 4562 1997 M12017 GO_ORGANOPHOSPHATE_ESTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSPORT.html The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. 42/106 Gene Ontology BP GO:0015748 4.33690976621071e-06 1.25537855639129e-05 2655 2280.72727272727 2094 3.94265301425694e-07 899 1.45241713816706 1.81732649171959 1 8.43284360535621 2653 899 2094 1987 1511 4257 2543 2806 1480 1454 3404 1998 M16292 GO_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 168/463 Gene Ontology BP GO:0009416 4.6735304309056e-07 2.8034116821602e-06 2095 2173.72727272727 2094 4.24866493065356e-08 628 1.49453793256647 1.68580426313871 1 9.83012226841151 2880 1372 1424 2094 628 4235 2094 2407 1880 1589 3308 1999 M16809 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. 10/36 Gene Ontology BP GO:0010575 0.000675533159864094 0.00104584877000633 1640 2159.36363636364 2094 6.14309707860861e-05 1639 1.65724522775981 1.79518772822534 1 5.85138148501576 1639 2608 1796 2012 2831 2628 2317 2244 1827 2094 1757 2000 M10316 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 27/84 Gene Ontology BP GO:0010518 5.13437859988657e-06 1.4334888658613e-05 4235 2494.90909090909 2095 4.66762780234719e-07 1225 2.41251449848693 -2.4426100365469 -1 13.8425710197381 4233 2429 1225 2095 1569 4018 3627 1918 1273 1404 3653 2001 M16810 GO_AMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving AMP, adenosine monophosphate. 10/18 Gene Ontology BP GO:0046033 0.00014675102821929 0.000256538036152923 2165 1922.63636363636 2095 1.33418925602523e-05 789 1.40886862099732 1.49409597702405 1 5.9930172319069 2058 1437 2162 2123 2520 2161 1319 2495 789 2095 1990 2002 M15840 GO_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTION.html The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. 627/2036 Gene Ontology BP GO:0000003 3.40188906752376e-07 2.42741103740133e-06 1710 2181.45454545455 2097 3.40188958830209e-08 509 1.76083418452885 1.8595812490674 1 11.7121108833756 1707 3421 4465 2607 509 2460 2097 2445 2058 795 1432 2003 M14926 GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of keratinocyte differentiation. 20/44 Gene Ontology BP GO:0045616 5.78259028493654e-07 3.16463969170349e-06 3880 2448.18181818182 2098 5.25690164078373e-08 719 2.14630274250813 -1.57106605216834 -1 13.9831853192263 3880 1904 1569 2098 719 2841 2992 4467 1044 1573 3843 2004 M15028 GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of B cell differentiation. 12/26 Gene Ontology BP GO:0045579 0.000141927191162631 0.000249043064462621 905 1756.81818181818 2098 1.29033043679693e-05 411 1.45592821904462 -1.45592821904462 -1 6.21540820128526 905 2600 2098 2627 2603 598 411 510 3658 2358 957 2005 M10486 GO_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical. 427/1214 Gene Ontology BP GO:0048878 1.8071679133363e-13 8.56191900165351e-12 95 2013.09090909091 2100 1.64287992121496e-14 91 1.72585500059965 1.80082734566158 1 22.6271113819857 2269 1138 91 990 498 4298 3291 4205 2100 91 3173 2006 M11194 GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. 24/79 Gene Ontology BP GO:0002792 0.000905538058383901 0.00137130241522389 915 2121.45454545455 2100 8.23555454734266e-05 913 1.31920135119414 1.43911410972852 1 4.47394006548521 913 2100 1742 2770 2906 1421 1123 2439 3698 2035 2189 2007 M13514 GO_REGULATION_OF_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of ion homeostasis. 113/303 Gene Ontology BP GO:2000021 4.33369816258404e-05 8.63948500166497e-05 1760 1919.18181818182 2101 3.93980321167856e-06 440 1.78891150791636 1.98828653899813 1 8.61129439623291 1760 1736 440 1367 2204 2791 2184 3448 2450 630 2101 2008 M11346 GO_APOPTOTIC_CELL_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_CELL_CLEARANCE.html The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. 19/46 Gene Ontology BP GO:0043277 6.83743444649761e-06 1.79991788410912e-05 2090 2187.90909090909 2102 6.21586881529254e-07 748 1.82250504233293 1.70994525119906 1 10.2437708995661 2086 2102 952 1453 1657 2721 2808 4302 2526 748 2712 2009 M15441 GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 34/82 Gene Ontology BP GO:0051785 0.000611336447623804 0.000957636682293293 3255 2240.63636363636 2102 5.55914901852541e-05 740 2.13121032578852 -2.3596021545804 -1 7.62146654424348 3253 3733 1245 2102 2956 1778 2403 740 2437 2032 1968 2010 M16087 GO_SOMITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITE_DEVELOPMENT.html The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 39/123 Gene Ontology BP GO:0061053 2.71854686500034e-05 5.76883596626901e-05 2105 2183.36363636364 2105 2.47143678068177e-06 1371 2.07709972228144 2.44647138360339 1 10.4301309377378 2105 3277 1624 2653 2059 2662 1760 1371 2283 2419 1804 2011 M15803 GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. 8/33 Gene Ontology BP GO:0002825 7.23776302742245e-06 1.89430291636541e-05 3410 2286 2106 7.23778660087665e-07 612 2.2106232525052 -2.11300772870219 -1 12.3671433206509 3409 612 4460 1679 1688 2624 2106 2973 2018 1061 2516 2012 M16947 GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. 73/199 Gene Ontology BP GO:0002700 9.27916921654162e-05 0.000169886367004743 2030 2174.63636363636 2106 8.43596419712878e-06 1212 1.77493339894778 -1.60046052121533 -1 7.9265309332945 2027 3656 1348 2106 2412 1212 2252 2734 2518 1559 2097 2013 M10258 GO_EMBRYONIC_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEMOPOIESIS.html The stages of blood cell formation that take place within the embryo. 15/26 Gene Ontology BP GO:0035162 0.00174804424848964 0.0025354664648715 1040 2052.54545454545 2108 0.000159039521024328 868 1.21916795348228 1.29100197157433 1 3.74918138396538 1039 2730 2546 2416 3031 1229 868 2059 2837 2108 1715 2014 M11454 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 63/113 Gene Ontology BP GO:0008630 6.17228524012931e-07 3.23818309264637e-06 2110 2089.09090909091 2108 5.61116997437871e-08 754 1.71518012395341 -1.09381357821779 -1 11.1541446571742 2108 2183 2332 1895 754 2713 2015 1852 1351 3358 2419 2015 M15089 GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. 76/213 Gene Ontology BP GO:0045834 1.70836046353172e-05 3.9015827015139e-05 2415 2186 2109 1.55306702687677e-06 757 1.75357003844213 1.8345365282709 1 9.15835588255832 2411 1836 757 846 1913 3795 2724 2526 2109 1766 3363 2016 M10269 GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 11/26 Gene Ontology BP GO:0051284 1.32579652167591e-05 3.13744813972541e-05 1755 2158.54545454545 2110 1.20527682859482e-06 1648 1.25769194051674 1.55831332103422 1 6.70957566807583 1755 1648 2110 1748 1841 3066 2764 2101 2139 2225 2347 2017 M11986 GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 11/36 Gene Ontology BP GO:0051973 3.13592044304093e-05 6.50584388607642e-05 1805 2013.45454545455 2111 2.85087740356314e-06 658 1.41602267610925 -1.41602267610925 -1 7.0229515274466 1805 3073 2675 3407 2111 658 888 1018 2556 2924 1033 2018 M13436 GO_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 66/188 Gene Ontology BP GO:0070555 4.92346208234776e-07 2.88267773623464e-06 1710 2072.63636363636 2111 4.47587562198913e-08 644 1.47139024341025 1.53918321384136 1 9.65676465046786 1710 1612 1099 2331 644 3142 3242 2111 2844 1179 2885 2019 M11222 GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. 15/31 Gene Ontology BP GO:1903392 0.000245410521746455 0.000411647779071095 1530 2244 2112 2.2312536511307e-05 1268 1.1748196621108 0.870000986039136 1 4.71160272737686 1526 1268 1866 1797 2632 2353 1835 3499 2814 2112 2982 2020 M10314 GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 6/18 Gene Ontology BP GO:0043517 5.91998903531044e-05 0.000113767070498123 1315 2260.27272727273 2114 5.92014674943949e-06 1315 1.57436404748932 1.57436404748932 1 7.35560242010363 1315 1590 3565 3438 2323 1709 1544 1761 2396 3108 2114 2021 M10636 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. 36/89 Gene Ontology BP GO:0032757 1.70641592519191e-05 3.8990596164695e-05 3180 2347.90909090909 2115 1.55129923731054e-06 1710 1.30742542574231 -1.52433960829317 -1 6.82871476054852 3180 2687 1749 2115 1912 1874 2883 1910 3238 2569 1710 2022 M11053 GO_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 189/412 Gene Ontology BP GO:0051186 9.28658193304437e-07 4.19986475613013e-06 815 1954.72727272727 2116 8.44235077552194e-08 474 1.34567579660798 -1.13946285142765 -1 8.57115775241813 815 2128 3086 3623 915 474 896 2367 2116 3816 1266 2023 M16499 GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. 8/16 Gene Ontology BP GO:0002903 4.01125355124947e-05 8.07293031575696e-05 1620 2195.18181818182 2118 4.01132595878669e-06 1129 1.51990194700967 1.86527741673595 1 7.36939792272992 1616 2118 4571 1621 2210 2503 3186 1129 1228 2547 1418 2024 M13691 GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that modulates the frequency, rate or extent of regulated secretory pathway. 66/188 Gene Ontology BP GO:1903305 5.02031444816846e-07 2.89556769973244e-06 3400 2285.90909090909 2120 4.56392326707733e-08 255 1.49154186884987 1.47404995399938 1 9.78559659878942 3397 255 1212 1355 659 4448 2822 4101 2120 676 4100 2025 M14081 GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). 7/24 Gene Ontology BP GO:0007191 0.00208603218427772 0.00299488170426762 645 2162.81818181818 2120 0.000208799296388812 642 1.77216024446095 1.77216024446095 1 5.29791480689701 642 2120 4181 1831 3080 1074 993 2271 4044 2392 1163 2026 M11719 GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 31/83 Gene Ontology BP GO:0030811 0.0131223760099665 0.0171771051069282 1180 2289.81818181818 2121 0.00120011883414061 1095 1.03019149919956 0.945650575370387 1 2.15403494016817 1179 2396 2121 3008 3682 1095 1233 1374 3854 3928 1318 2027 M11947 GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT.html The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. 66/243 Gene Ontology BP GO:0015850 3.73018270116597e-09 8.70313481483094e-08 2435 2177.54545454545 2122 3.39107518862785e-10 181 2.06472269121785 1.96652210471847 1 17.2688906399587 2432 1535 181 1114 1624 4220 3112 4121 2122 493 2999 2028 M15446 GO_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRINOLYSIS.html A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. 5/29 Gene Ontology BP GO:0042730 2.82194531409111e-05 5.95558731514775e-05 2455 2359.09090909091 2123 2.82198114992068e-06 1096 1.93208726001056 2.07947249756582 1 9.67028396167605 2455 2123 4407 1164 2103 3439 3382 1780 1324 1096 2677 2029 M15733 GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 12/29 Gene Ontology BP GO:1902893 2.21146167715914e-06 7.70480727447095e-06 850 1726.18181818182 2124 2.01042172740485e-07 95 1.59618150257891 1.59618150257891 1 9.66843821528528 846 3777 2294 3001 2572 471 436 95 2124 3059 313 2030 M14456 GO_MONOCARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSPORT.html The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 53/209 Gene Ontology BP GO:0015718 1.98448861944518e-05 4.41282598663025e-05 2500 1810.36363636364 2125 1.80409683687088e-06 399 1.73626819788613 1.89549918884317 1 8.95800355762874 1366 1387 399 1517 2383 2500 2296 2609 2496 836 2125 2031 M16792 GO_LUNG_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_ALVEOLUS_DEVELOPMENT.html The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. 29/56 Gene Ontology BP GO:0048286 3.58430224251449e-06 1.0813460241712e-05 2140 2090 2125 3.25846189288585e-07 685 1.55150399380147 1.50478525056771 1 9.12726632230419 2139 2191 1025 2125 1442 2828 1992 3855 3069 685 1639 2032 M10479 GO_VENTRICULAR_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_MORPHOGENESIS.html The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. 22/43 Gene Ontology BP GO:0060412 6.1134878615902e-06 1.64932737602343e-05 2130 2298.54545454545 2126 5.55773168197424e-07 554 1.52670938435355 1.51156558921303 1 8.64981679012347 2126 1331 1044 1796 1613 3398 3605 4133 3032 554 2652 2033 M15005 GO_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 290/763 Gene Ontology BP GO:0043900 3.57174522778325e-07 2.49281718252034e-06 3165 1992.54545454545 2126 3.24704164333051e-08 489 1.53812083335982 -1.38756505167217 -1 10.2097028353052 3162 2126 1535 2268 489 732 2852 2841 2350 1558 2005 2034 M10124 GO_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ACTIVATION.html A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. 245/670 Gene Ontology BP GO:0045321 8.08276574948981e-07 3.80357314464001e-06 3530 2407.09090909091 2127 7.34797156280626e-08 802 1.52380168327823 1.80606065084857 1 9.78341319247206 3528 2127 802 1155 867 3539 3971 3375 2005 1080 4029 2035 M10250 GO_FATTY_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 46/95 Gene Ontology BP GO:0009062 3.26579113607602e-05 6.73016788495382e-05 1175 2005.63636363636 2127 2.96894510557903e-06 735 1.53697363979142 -1.63300824648728 -1 7.59601875655602 1174 2654 2714 3523 2127 814 1129 735 2424 3529 1239 2036 M12732 GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 25/101 Gene Ontology BP GO:0050805 3.02186809559319e-06 9.54545968254934e-06 1990 2345.09090909091 2127 2.74715658760717e-07 1328 1.49205678511918 1.52484587180488 1 8.87328975211008 1989 3713 2023 3171 1378 2689 1328 1950 2728 2127 2700 2037 M15668 GO_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_RESORPTION.html The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. 16/39 Gene Ontology BP GO:0045453 8.74060773543826e-06 2.20557835411086e-05 4265 2663.18181818182 2127 7.94603860190607e-07 1152 1.32108717043168 1.20758197821697 1 7.28730566067409 4262 1562 2111 1503 1719 4126 3930 2918 2127 1152 3885 2038 M12770 GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. 10/22 Gene Ontology BP GO:0061029 1.02883882242427e-05 2.53820332227199e-05 1775 2165 2128 9.35312394419803e-07 710 1.29801889893668 1.44934054333511 1 7.06625472404768 1774 710 1758 2044 1763 2635 2461 3466 2253 2823 2128 2039 M13350 GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 25/86 Gene Ontology BP GO:0050922 0.000298915878457345 0.000492151214070018 2760 1706.72727272727 2130 2.71778636491102e-05 531 1.64185033732628 1.80944791627596 1 6.43374902867615 920 568 531 756 2760 2452 2130 2578 2759 911 2409 2040 M16821 GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS.html The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. 25/72 Gene Ontology BP GO:0048701 7.64277412450175e-07 3.66584713430389e-06 4530 2434.81818181818 2130 6.9479788905398e-08 851 1.68307408591478 -1.86871482283206 -1 10.8379410904546 4529 993 1712 1261 851 3811 4356 2309 1140 2130 3691 2041 M12270 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. 56/124 Gene Ontology BP GO:0090317 4.65518472338719e-07 2.80251696730727e-06 2115 2045.54545454545 2131 4.23198700765577e-08 624 1.1599458068829 1.50933738461607 1 7.62957766844651 2112 1891 2517 2143 624 2854 1153 2131 2481 3063 1532 2042 M13620 GO_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 51/167 Gene Ontology BP GO:0032368 3.86850507463121e-05 7.83317447078618e-05 1315 2014.18181818182 2131 3.51688463685455e-06 930 1.72106290877201 1.99906853567203 1 8.37144220771213 1311 2389 1455 1930 2171 2120 2423 3113 2183 2131 930 2043 M14202 GO_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of endocytosis. 131/321 Gene Ontology BP GO:0030100 5.97165475196925e-07 3.22535002324623e-06 3515 2380.72727272727 2131 5.42877852082635e-08 489 1.69390499093801 -1.57101709931669 -1 11.0192489037213 3514 876 513 961 730 4485 3980 4245 2131 489 4264 2044 M14730 GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. 86/294 Gene Ontology BP GO:0030522 6.65101292940842e-06 1.76158887799448e-05 2095 2127.81818181818 2132 6.04639366977633e-07 1360 1.54349018376564 -1.55928248250299 -1 8.69260180229762 2091 2717 2242 2270 1647 1360 3125 2494 2132 1715 1613 2045 M13047 GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. 6/22 Gene Ontology BP GO:1903055 8.87739951849932e-05 0.000162916071005503 2135 2203.54545454545 2133 8.87775417543949e-06 736 1.58155558338984 1.58155558338984 1 7.09702874808071 2133 2646 3999 736 2430 3030 1643 1647 1017 3132 1826 2046 M14983 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. 5/18 Gene Ontology BP GO:1902285 0.0696368530974636 0.0846176155277476 865 2444.54545454545 2134 0.00719204144450932 865 2.53661351972396 2.53661351972396 1 3.22288907919833 865 2373 4329 2134 3602 1536 1192 2106 3919 3002 1832 2047 M15444 GO_MYOTUBE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_CELL_DEVELOPMENT.html The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 11/39 Gene Ontology BP GO:0014904 0.00514042186355745 0.00707589051660162 1140 2213.81818181818 2134 0.000468406561925635 388 5.02790383837703 5.02790383837703 1 12.8070080224558 1532 4008 1339 3258 4082 2134 1138 1140 388 2942 2391 2048 M11394 GO_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 39/100 Gene Ontology BP GO:0005976 9.88711433742181e-05 0.000179530198938793 1380 2100.36363636364 2136 8.98868973311451e-06 1342 1.43499489445535 1.56059069419576 1 6.36766449825974 1376 2136 2349 2899 2433 1771 1342 1897 2404 2753 1744 2049 M15674 GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune effector process. 246/673 Gene Ontology BP GO:0002697 1.28555892247574e-06 5.28684683530103e-06 2960 1863.36363636364 2136 1.16869061244203e-07 846 1.64660051203981 -1.48449117093092 -1 10.2928864102011 2957 1600 846 2156 1040 1174 3117 2392 2164 915 2136 2050 M15894 GO_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. 23/67 Gene Ontology BP GO:0048806 3.34352437248726e-05 6.86294591576408e-05 3115 2284.27272727273 2138 3.03961380719128e-06 548 2.64293836512223 2.96403524983151 1 13.0353455023585 3114 1255 1051 814 2138 4092 3330 4540 548 1436 2809 2051 M16330 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 12/38 Gene Ontology BP GO:0035774 0.00231648168701105 0.00330630939833763 1395 2081.27272727273 2140 0.000210811310845593 880 1.59944513980754 1.93976912630498 1 4.7001739092807 1393 3318 2140 2683 3098 1198 1779 1500 2541 2364 880 2052 M16559 GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. 20/64 Gene Ontology BP GO:0034308 0.0217115973998079 0.0277858177307905 1965 2580.63636363636 2140 0.00199353410555615 1506 1.29065736879773 -1.41268185698697 -1 2.37929176401705 1965 2662 2028 4145 4154 1750 2140 1506 3338 2652 2047 2053 M12098 GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 14/26 Gene Ontology BP GO:0002068 6.99860165026349e-07 3.49403306044875e-06 3925 2394.18181818182 2142 6.36236716058857e-08 311 1.48620689565213 -1.0530562876706 -1 9.6069432578344 3924 1707 2142 2135 804 4143 3380 2805 311 2002 2983 2054 M10368 GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. 45/129 Gene Ontology BP GO:0002821 9.5943471575924e-05 0.000174418769979254 1925 2268.09090909091 2144 8.72251418094338e-06 1049 1.49237519034253 -1.37750728489339 -1 6.64446159101325 1924 2908 2133 2928 2429 1049 1956 2144 3050 2758 1670 2055 M11157 GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. 78/206 Gene Ontology BP GO:1901136 4.68543498892164e-07 2.8034116821602e-06 2600 2247.63636363636 2145 4.25948726072659e-08 630 1.48457591847629 1.83215037975138 1 9.7645984491991 2599 1239 1567 2532 630 3964 2940 1758 2028 2145 3322 2056 M12025 GO_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENTATION.html The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. 47/105 Gene Ontology BP GO:0043473 5.18931327091395e-06 1.44361782605473e-05 2890 2323.18181818182 2145 4.7175686467239e-07 1572 1.4595115275694 -1.29353676614547 -1 8.36912498622243 2889 1785 2145 2201 1572 2027 4267 1971 1685 2564 2449 2057 M12896 GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. 122/332 Gene Ontology BP GO:0043903 5.01719433362426e-07 2.89556769973244e-06 2600 2127.81818181818 2145 4.56108679801573e-08 657 1.37304519001089 -1.33913287314111 -1 9.00817229652118 2597 2774 2289 3451 657 1001 2145 1947 3131 1941 1473 2058 M12102 GO_CELLULAR_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 8/23 Gene Ontology BP GO:0071318 5.99748436179176e-05 0.000114972419041285 1475 1886.36363636364 2146 5.9976462321243e-06 173 2.14789063990979 2.14789063990979 1 10.0235364211816 1475 2208 3849 2254 3391 1129 173 1295 2146 2523 307 2059 M10417 GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 22/54 Gene Ontology BP GO:0000271 5.40175586656571e-05 0.000104894824293035 1805 2073.09090909091 2147 4.91080772980975e-06 897 1.52173429057306 1.66789541557994 1 7.17327711717865 1801 2502 2488 2088 2267 2555 1786 1415 897 2858 2147 2060 M15567 GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of leukocyte degranulation. 24/56 Gene Ontology BP GO:0043300 1.38205511855032e-06 5.55574191812047e-06 3200 2204.63636363636 2147 1.2564145334251e-07 1063 1.52416186042407 -1.7236867686906 -1 9.48862212029436 3200 1182 2147 1843 1063 2122 3495 2608 1691 2505 2395 2061 M11937 GO_CYTOCHROME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 17/27 Gene Ontology BP GO:0017004 3.48201182147837e-05 7.11888194060946e-05 900 2092.72727272727 2148 3.16551539421583e-06 593 0.68163352665808 -0.68163352665808 -1 3.34907179838528 896 2157 3252 3637 2148 596 593 750 3731 4301 959 2062 M13521 GO_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_REMODELING.html Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. 22/59 Gene Ontology BP GO:0046850 0.000195435891746269 0.000334343716056715 3755 2134.63636363636 2148 1.77684777595256e-05 1036 1.8923742572141 -2.14689019160183 -1 7.79185159569108 3754 2148 1066 1800 2582 2478 2535 1036 1721 1324 3037 2063 M10222 GO_SULFUR_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 185/421 Gene Ontology BP GO:0006790 1.0293902962321e-06 4.49016470728422e-06 3785 2216.36363636364 2149 9.35809798080862e-08 228 1.49782198838136 -1.33670951694355 -1 9.48873518385219 3785 228 1134 2149 952 2213 4633 3722 1815 1457 2292 2064 M15396 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. 17/46 Gene Ontology BP GO:0032736 0.0839184282471183 0.0949861682962873 1635 2365.36363636364 2149 0.00793650793650794 1634 1.91630096009507 -1.88876695224312 -1 2.32079457600234 1634 3067 1642 2056 3743 2149 2923 2442 1949 1802 2612 2065 M11115 GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 106/228 Gene Ontology BP GO:0044272 1.21762428321771e-06 5.05221585967812e-06 4215 2570.09090909091 2150 1.10693177921033e-07 49 1.45090137048384 -1.27353138226462 -1 9.10345758948662 4213 49 1432 2150 1022 4026 3198 4440 1926 1944 3871 2066 M13469 GO_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 21/70 Gene Ontology BP GO:0048708 9.51152927293092e-05 0.000173320370542458 2900 2152.09090909091 2150 8.64721865582728e-06 796 1.91726138640729 2.14155915666511 1 8.5424027053877 2897 2150 1659 1264 2423 4025 3529 1143 796 1221 2566 2067 M16308 GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 25/46 Gene Ontology BP GO:0060444 3.56532695618467e-05 7.273204331092e-05 3470 2330.90909090909 2150 3.2412588520882e-06 455 1.90159614912296 1.69269811645059 1 9.32213906157624 3468 1404 1101 463 2150 3990 2932 4407 455 675 4595 2068 M12875 GO_ENDOCRINE_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. 20/51 Gene Ontology BP GO:0031018 0.000222242539531564 0.000376046687698635 3865 2604.36363636364 2151 2.02059085000942e-05 1159 1.59036774655076 -1.3853841648962 -1 6.45216501782177 3863 2151 1765 1709 2614 4104 3789 1716 1159 2136 3642 2069 M16736 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS.html Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. 19/76 Gene Ontology BP GO:0021955 0.00109047136927288 0.00162485833361167 2105 2361.27272727273 2151 9.91829324810536e-05 1344 1.72840573878896 1.73463279296716 1 5.71085214229448 2101 3880 2151 2148 2943 2470 1448 3031 1344 2030 2428 2070 M16752 GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT.html Any process that modulates the frequency, rate or extent of synaptic vesicle transport. 22/58 Gene Ontology BP GO:1902803 2.56709691910349e-06 8.48933831581019e-06 2095 2349.90909090909 2151 2.33372719505167e-07 1314 1.063266776254 1.12936231878007 1 6.38740782586468 2095 1631 2574 2983 1314 2034 2151 3600 3313 2312 1842 2071 M15814 GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 14/56 Gene Ontology BP GO:0007215 1.3669018246395e-06 5.51392282519653e-06 3695 2310.72727272727 2152 1.24263879447485e-07 1012 1.60815965134423 -1.68065919273841 -1 10.0177990457944 3691 1012 1450 2421 1058 3670 2152 1963 2160 1399 4442 2072 M16049 GO_STRIATED_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_ADAPTATION.html Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 19/42 Gene Ontology BP GO:0014888 0.000311856296528524 0.000512366873595874 2410 2220.18181818182 2152 2.83545919841873e-05 630 2.92102591565231 3.48410096854393 1 11.3858287163078 2409 2152 921 1884 2680 3228 3158 2097 630 2028 3235 2073 M13707 GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. 18/43 Gene Ontology BP GO:2000300 2.55758787105338e-05 5.49709124790502e-05 1155 1955.27272727273 2153 2.32510691319804e-06 722 1.18529219068581 1.28695624184476 1 5.98135319598951 1154 2153 2453 2986 2030 722 882 2588 3350 2444 746 2074 M16069 GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that modulates the frequency, rate or extent of the viral entry into the host cell. 21/69 Gene Ontology BP GO:0046596 1.12185840535669e-05 2.72141513901313e-05 3250 2125.45454545455 2153 1.01987647832124e-06 1225 1.66522331830953 1.29405953761283 1 9.00556173837919 3248 1846 1457 2153 1789 2535 2278 1304 2553 1225 2992 2075 M12703 GO_CELLULAR_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. 36/154 Gene Ontology BP GO:0034754 5.22986955900122e-07 2.9677135837766e-06 4385 2397.54545454545 2155 4.75442800204841e-08 677 1.75144325746674 -1.44055687835813 -1 11.4685626304598 4384 1394 1164 1034 677 3154 3630 4017 871 2155 3893 2076 M12064 GO_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION.html The controlled release of a substance by a cell or a tissue. 309/906 Gene Ontology BP GO:0046903 3.40557197397797e-10 9.41194683046412e-09 2280 1821.90909090909 2156 3.09597452227742e-11 156 1.76396733849856 1.91865343904195 1 16.7720093993084 2278 740 156 913 429 3402 2233 3899 2156 320 3515 2077 M14375 GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 16/26 Gene Ontology BP GO:2001269 2.84255167744047e-05 5.98818849290203e-05 2720 2230.36363636364 2156 2.58417127802936e-06 812 1.57306367966862 1.4753196160647 1 7.86891778079603 2716 1421 2156 812 2078 3736 1752 3804 1125 2262 2672 2078 M11129 GO_REGULATION_OF_NOREPINEPHRINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOREPINEPHRINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. 6/23 Gene Ontology BP GO:0014061 0.000741150336876646 0.00114021239699081 1605 2057.27272727273 2157 7.41397639687125e-05 690 2.21902707850321 2.21902707850321 1 7.73629412636339 1601 1915 3697 2236 2882 2385 2157 1366 690 2173 1528 2079 M14130 GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of anion transmembrane transport. 16/44 Gene Ontology BP GO:1903959 0.00091215963114268 0.00137997952668474 1350 1843.36363636364 2158 8.29580044212685e-05 531 1.17527220836373 0.975032100373642 1 3.98200459406087 1347 2158 2636 2220 2907 962 531 2444 1688 2261 1123 2080 M14878 GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. 98/266 Gene Ontology BP GO:0050866 5.19927483044653e-06 1.44465787179912e-05 3440 2600.09090909091 2159 4.72662465269858e-07 362 1.77852450409763 -1.67864155424121 -1 10.1977492783941 3437 2004 362 1684 1921 4114 4163 4259 2159 448 4050 2081 M10974 GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. 56/165 Gene Ontology BP GO:0048525 8.95857938765113e-07 4.0939649701638e-06 2250 1975.27272727273 2162 8.14416639605434e-08 902 1.4855467771191 -1.50856205021446 -1 9.48157153903083 2248 2215 1881 2465 902 1453 2292 1035 2974 2101 2162 2082 M16768 GO_MULTI_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_BEHAVIOR.html Any process in which an organism has a behavioral effect on another organism of the same or different species. 23/106 Gene Ontology BP GO:0051705 3.75188508807663e-05 7.61363744053313e-05 4395 2465.45454545455 2164 3.41086279485401e-06 685 1.91059218605295 -1.37063932645104 -1 9.32127603548681 4394 810 1815 1173 2164 4334 2648 2096 685 2426 4575 2083 M14173 GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 7/18 Gene Ontology BP GO:0070498 0.00403429700885161 0.00560815599164611 1450 2314.45454545455 2165 0.000404163977553556 1356 0.904821128817342 -1.07133814085881 -1 2.41296341754945 1448 2449 4197 2165 3185 1356 1974 1633 2971 2394 1687 2084 M15678 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 5/16 Gene Ontology BP GO:0043455 7.22447025059365e-06 1.89189031999472e-05 3400 2375.72727272727 2165 7.22449373753778e-07 22 3.2951678642188 -1.53561774604294 -1 18.4366970019228 3399 1366 4439 340 1687 4179 3844 2165 22 1990 2702 2085 M11395 GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of intracellular signal transduction. 883/2243 Gene Ontology BP GO:1902531 1.13299713228061e-07 1.30788161684886e-06 1960 1945.18181818182 2168 1.13299719004632e-08 1 1.5161864346162 1.66720266755928 1 10.5672345073366 1957 1 3736 1195 161 4127 2704 2536 2168 288 2524 2086 M12767 GO_POSITIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIVISION.html Any process that activates or increases the frequency, rate or extent of cell division. 61/192 Gene Ontology BP GO:0051781 1.49430909154369e-05 3.47251106708577e-05 4555 2793.09090909091 2168 1.35847203768805e-06 1109 1.87989821882615 -1.83515476763409 -1 9.93080705538649 4554 3657 1109 1757 1873 3730 4194 2168 2129 1772 3781 2087 M11544 GO_PROTEIN_LOCALIZATION_TO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CENTROSOME.html A process in which a protein is transported to, or maintained at, the centrosome. 10/22 Gene Ontology BP GO:0071539 0.00408187167690011 0.00566919838344219 1335 2387.18181818182 2169 0.000371769536118823 785 0.823974669619312 -0.823974669619312 -1 2.19277396509685 1333 2169 3172 2719 3488 785 1561 1864 3909 4279 980 2088 M12850 GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. 10/18 Gene Ontology BP GO:0035024 0.0305160899354897 0.0385855679658166 900 2413.72727272727 2169 0.00281343490353633 900 1.2947100610825 1.2947100610825 1 2.16804940712187 900 2960 1829 2163 3774 2169 2227 1605 4179 2824 1921 2089 M11111 GO_LYMPH_NODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_NODE_DEVELOPMENT.html The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. 8/17 Gene Ontology BP GO:0048535 2.59062181076631e-05 5.55321194246906e-05 1585 2259.36363636364 2171 2.59065201220798e-06 1190 1.00676410812526 -1.00676410812526 -1 5.07518363595511 1582 1770 3693 2855 2081 1513 1190 2254 3227 2517 2171 2090 M10827 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. 49/123 Gene Ontology BP GO:1903428 1.48111846885516e-06 5.81304568968258e-06 3005 2443.72727272727 2172 1.34647224181625e-07 939 1.36722673486238 1.19211184544933 1 8.47978237458131 3004 1616 1807 939 1090 3962 2834 3813 2172 1592 4052 2091 M11026 GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 6/16 Gene Ontology BP GO:0009070 0.000908572725347019 0.00137544935239198 1135 2020.63636363636 2172 9.08944416225457e-05 597 1.2092305055744 1.2092305055744 1 4.09910625491208 1135 3329 3671 2202 2925 676 597 1409 3075 2172 1036 2092 M11855 GO_REGULATION_OF_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENERGY_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of energy homeostasis. 12/44 Gene Ontology BP GO:2000505 8.24863785444058e-05 0.000152522602780436 1945 2224.36363636364 2172 7.49904285774837e-06 435 2.51232556181936 2.51232556181936 1 11.3589473602626 1942 3122 1151 2172 3432 2930 3606 435 1609 3043 1026 2093 M12566 GO_EMBRYONIC_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_FORELIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 17/50 Gene Ontology BP GO:0035115 1.25388584241609e-07 1.38614094436617e-06 2175 2022.27272727273 2172 1.13989628534644e-08 162 1.63517163424195 1.380217598267 1 11.3476263863824 2172 1007 1329 2155 162 2847 1425 2982 2434 2324 3408 2094 M12774 GO_PIGMENT_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. 26/55 Gene Ontology BP GO:0046148 3.87524771595817e-05 7.84340677645762e-05 1215 2044.45454545455 2172 3.52301452655376e-06 562 1.74877686706801 -1.56010362785646 -1 8.50507153404505 1212 3466 2825 3649 2172 562 705 905 2391 3603 999 2095 M10300 GO_REGULATION_OF_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATURATION.html Any process that modulates the frequency, rate or extent of cell maturation. 10/24 Gene Ontology BP GO:1903429 3.87861762596755e-05 7.84680681366768e-05 2330 2055.81818181818 2173 3.52607818908624e-06 601 1.45245534563712 -1.25258824334116 -1 7.06360542592259 2326 601 2061 738 2173 1445 1054 3613 3059 2805 2739 2096 M12283 GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that activates or increases the activity of an enzyme. 766/1913 Gene Ontology BP GO:0043085 1.68140237801036e-07 1.62980192924887e-06 2175 2146.81818181818 2173 1.6814025052305e-08 272 1.57946443862287 1.68490545156415 1 10.8294473008061 2173 1224 3882 859 272 4364 2894 2680 2055 337 2875 2097 M11175 GO_RENAL_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. 6/19 Gene Ontology BP GO:0072087 7.95032748147444e-06 2.04619570379633e-05 3410 2241.54545454545 2174 7.95035592508585e-07 268 2.43859104211991 -2.79141345529703 -1 13.5457216737953 3410 726 3702 1055 1720 2519 1418 3150 268 2174 4515 2098 M11401 GO_CLATHRIN_COAT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_ASSEMBLY.html The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. 6/13 Gene Ontology BP GO:0048268 3.89746172561613e-05 7.87463655005906e-05 1630 2129.90909090909 2175 3.89753008323904e-06 728 1.56035406267208 -1.56035406267208 -1 7.58549836176409 1628 3419 3737 3148 2202 1469 728 900 3111 2175 912 2099 M15386 GO_CEREBELLAR_CORTEX_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_FORMATION.html The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 17/45 Gene Ontology BP GO:0021697 8.67005395624533e-05 0.000159615624579092 2805 2252.81818181818 2175 7.88217786924458e-06 723 1.61081994136083 -1.41691084247862 -1 7.24530998188378 2805 1264 1315 723 2394 2647 4610 4018 1029 1801 2175 2100 M10147 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT.html The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. 7/15 Gene Ontology BP GO:0010248 3.54116601851076e-05 7.22709179074525e-05 4485 2485.63636363636 2176 3.54122244913182e-06 730 1.8273092380515 -2.28976312783162 -1 8.96394371835479 4485 1442 3543 1365 2176 4189 1382 730 1453 2370 4207 2101 M11687 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 14/47 Gene Ontology BP GO:0048147 4.4590398418206e-05 8.86272345272819e-05 2180 2013.09090909091 2176 4.0537547471118e-06 314 2.00668619813902 2.44974249545553 1 9.63326065538274 2176 2160 1997 1710 2213 2700 2241 1008 314 3239 2386 2102 M15938 GO_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORT.html The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 25/104 Gene Ontology BP GO:0015908 0.000857643196324035 0.00130302269650932 1390 2259.36363636364 2177 7.79979746057828e-05 1177 1.30054856645544 1.57071604979572 1 4.44485459206413 1390 1903 1177 2477 2892 2177 2536 2074 3694 2606 1927 2103 M14800 GO_HISTONE_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). 7/14 Gene Ontology BP GO:0071044 0.00141727181760367 0.0020804277739911 1495 2479.09090909091 2178 0.000141817652651317 1031 0.625996888125577 -0.625996888125577 -1 1.98876727076217 1586 2178 4294 3070 3009 1031 1156 1495 3458 4501 1492 2104 M16243 GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that activates or increases the rate of ATP hydrolysis by an ATPase. 34/76 Gene Ontology BP GO:0032781 0.0839184282471183 0.0949861682962873 2140 2551.63636363636 2178 0.00793650793650794 1482 1.62649168583091 1.45953282319384 1 1.96981198340567 2140 3594 1482 2045 4517 2842 1802 2901 2178 2435 2132 2105 M11758 GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. 67/154 Gene Ontology BP GO:1903650 2.6996788834494e-06 8.77773743407253e-06 1985 2163.18181818182 2179 2.45425654209392e-07 995 1.20807790189087 -0.77037564008881 -1 7.23657449196118 1983 2338 2158 2771 1334 2377 1367 2179 2989 3304 995 2106 M14284 GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 9/38 Gene Ontology BP GO:0060117 0.017202966557811 0.0222798810956532 1410 2368.90909090909 2179 0.00173376097851225 851 1.85659186550526 -1.85659186550526 -1 3.63351780174527 1407 3639 4217 2775 3397 1691 1734 1474 851 2694 2179 2107 M16270 GO_DEFENSE_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_FUNGUS.html Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. 18/101 Gene Ontology BP GO:0050832 0.000390598194341194 0.000630360589616324 2180 2365.81818181818 2179 3.55152327451754e-05 1143 2.61336712461686 2.48586295165962 1 9.90795895243677 2179 1802 1143 2233 2726 3475 3397 4376 1403 1882 1408 2108 M14890 GO_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTHENED_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. 34/88 Gene Ontology BP GO:0007224 0.000244230269716104 0.000409839980806127 1555 2293.36363636364 2180 2.2205216986456e-05 1119 1.0849955272575 1.05099259564333 1 4.35382058802787 1554 1924 2992 3104 2630 1663 1119 2180 3142 2873 2046 2109 M14917 GO_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEATH.html Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 854/2183 Gene Ontology BP GO:0010941 3.54474022043212e-07 2.49281718252034e-06 1930 2098.27272727273 2181 3.54474078586549e-08 210 1.61710596948547 1.78482545777999 1 10.7339886284567 1927 1777 4316 1681 536 3550 2310 2317 2181 210 2276 2110 M11024 GO_HEME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_METABOLIC_PROCESS.html The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 21/37 Gene Ontology BP GO:0042168 3.96708265843266e-05 8.00007240030488e-05 3800 2270.27272727273 2182 3.60650381403849e-06 472 2.05457734853001 2.68425683701162 1 9.97140905265723 3800 1697 2174 1215 2182 2773 3680 1450 472 2731 2799 2111 M14611 GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. 10/28 Gene Ontology BP GO:0031146 0.00309503962333486 0.00434870317092397 1320 2347.36363636364 2183 0.000281763857488762 1182 1.22750100972203 -1.22750100972203 -1 3.43410433874845 1318 3641 2672 2994 3131 1182 2183 1990 2986 2079 1645 2112 M13924 GO_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 20/54 Gene Ontology BP GO:0034605 0.00916682082124536 0.0122373631607367 850 2419.18181818182 2184 0.000836840078059488 847 1.8997621430192 1.86061257259164 1 4.30364010306735 847 4190 1978 3832 4166 952 935 2184 3709 2646 1172 2113 M10763 GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 26/78 Gene Ontology BP GO:0090218 0.00183814614470308 0.00265376634012948 1230 2251.18181818182 2186 0.000167243977568051 1089 1.74409863577331 1.75416007207363 1 5.32252874788201 1226 3522 1732 2695 3040 1913 1089 1545 3155 2660 2186 2114 M11822 GO_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_PROLIFERATION.html The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 35/97 Gene Ontology BP GO:0072089 6.63594476248983e-05 0.000125503977030855 2190 2298.09090909091 2186 6.03285903045586e-06 608 2.21639329149803 2.43718627596646 1 10.2432774802812 2186 2627 1679 2131 2330 3999 3530 1810 608 2098 2281 2115 M13654 GO_RECEPTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 44/123 Gene Ontology BP GO:0043112 1.70934016617431e-07 1.64536676578834e-06 1980 1955.54545454545 2186 1.55394572635037e-08 249 1.46996364553735 1.58617597744764 1 10.0714773544514 1980 2394 1490 2335 249 2239 2027 2186 2401 2012 2198 2116 M12798 GO_MAINTENANCE_OF_LOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION.html Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. 83/197 Gene Ontology BP GO:0051235 1.0629671490217e-07 1.2747239667869e-06 3835 2485.81818181818 2187 9.66333818527958e-09 128 1.44759349513114 1.62644658380826 1 10.1082925384445 3833 1379 2187 1020 128 3122 3819 3452 2154 2106 4144 2117 M13634 GO_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_SORTING_PATHWAY.html A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. 6/12 Gene Ontology BP GO:0071985 3.33869967129884e-05 6.85722512021548e-05 2390 2441 2187 3.33874983347925e-06 1505 1.52023669276952 -1.16860654130382 -1 7.49867371553675 2388 1775 4109 2748 2159 1505 1910 3915 1716 2187 2439 2118 M12329 GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 10/22 Gene Ontology BP GO:0098911 0.000422652396870768 0.000678083994012085 2190 2108.63636363636 2188 3.84303287696213e-05 821 1.73177689012795 1.0087422730069 1 6.50059808251514 2188 2640 1928 2144 2740 1502 954 821 2265 2817 3196 2119 M13958 GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 6/18 Gene Ontology BP GO:0001574 0.00951855909017786 0.0126632291850131 1315 2339.63636363636 2188 0.000955957792101562 587 1.84955840494846 -1.52785069628539 -1 4.15735951842653 1313 2525 4166 2574 3535 1629 587 2080 3831 2188 1308 2120 M15977 GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. 53/146 Gene Ontology BP GO:0031098 5.74122783309291e-07 3.15088898688539e-06 2805 2222.54545454545 2191 5.21929939213856e-08 716 1.37439806884373 -1.40955571708329 -1 8.95729659034181 2803 2255 2191 2279 716 2006 3957 1942 2634 1557 2108 2121 M14676 GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. 6/23 Gene Ontology BP GO:1902259 0.000235340143188098 0.000396775686739495 715 1974.90909090909 2192 2.35365070145859e-05 359 1.43429809389327 1.43429809389327 1 5.77939156409206 714 2486 4271 3024 2646 494 359 1485 3354 2192 699 2122 M11724 GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 82/222 Gene Ontology BP GO:0070304 2.23304261379726e-06 7.72579497456087e-06 2195 2151.90909090909 2195 2.03004080034726e-07 744 1.54958500393992 1.64681945705561 1 9.38402381161726 2195 2006 1094 1638 1251 3463 2415 3490 2824 744 2551 2123 M16961 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. 17/23 Gene Ontology BP GO:0032703 0.0022740535740474 0.00324874792132371 1525 2208.09090909091 2195 0.000206946143739944 1420 1.66862578212904 1.70119009353823 1 4.91854724382421 1522 2195 1420 2040 3078 2012 1744 3131 2213 2334 2600 2124 M15838 GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 17/27 Gene Ontology BP GO:0033598 0.000163298634509463 0.000282171775224205 3910 2342.81818181818 2196 1.48464324436482e-05 381 1.88851387170916 -1.77168804869921 -1 7.94078996455481 3908 2196 1655 985 2556 3486 3936 2138 381 1240 3290 2125 M13277 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. 17/50 Gene Ontology BP GO:0071825 9.1160612926062e-05 0.000167097799374539 2565 2386.90909090909 2197 8.28767186681018e-06 1342 1.63742945486456 1.88653065634158 1 7.32640547519819 2563 1342 1622 1901 2407 3935 2871 3726 1897 1795 2197 2126 M14099 GO_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. 526/1416 Gene Ontology BP GO:0006629 3.25102821207951e-07 2.34751539481884e-06 2860 2115.09090909091 2197 3.2510286876929e-08 493 1.47459186405579 -1.38373880191365 -1 9.83357235696186 2859 497 4185 1641 493 1464 3795 2812 2197 728 2595 2127 M11329 GO_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 516/1254 Gene Ontology BP GO:0051338 2.45705254141973e-07 2.00203502611962e-06 2305 2283 2198 2.45705281308959e-08 403 1.54058451374664 1.72352191786236 1 10.3998307367496 2302 2211 3731 1551 403 4394 3005 2046 2198 1165 2107 2128 M13899 GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. 72/173 Gene Ontology BP GO:0006367 1.58294665054601e-05 3.64926578872152e-05 1995 2172.45454545455 2198 1.43905276390687e-06 716 1.24948087952783 -1.42828260327755 -1 6.56862990356204 1994 3362 3149 3113 1890 716 2198 949 2463 3230 833 2129 M16437 GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. 5/15 Gene Ontology BP GO:1900121 0.000564153776731018 0.00088919773167237 1645 2241.09090909091 2198 5.64297049192252e-05 715 1.43585804499691 1.43585804499691 1 5.18957639861565 1644 1996 4564 2321 2808 2198 1446 2350 715 3008 1602 2130 M11437 GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. 12/44 Gene Ontology BP GO:0045920 0.000205972565752096 0.000351075852711814 3030 2260.45454545455 2199 1.87265320212412e-05 1605 1.6015677544741 -1.89475939403466 -1 6.55421908961793 3028 2199 1605 2051 2592 2329 2996 1895 2399 1645 2126 2131 M14683 GO_REPLICATIVE_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATIVE_SENESCENCE.html A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. 10/22 Gene Ontology BP GO:0090399 0.000340051151229112 0.000553596597179792 1150 1996.72727272727 2199 3.09185203520089e-05 588 2.72163223420706 2.72163223420706 1 10.5002451802901 1148 2897 1451 2964 3018 2199 2007 629 588 2831 2232 2132 M15190 GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. 14/45 Gene Ontology BP GO:0042743 2.48432916582462e-06 8.31123353602257e-06 2235 2196.45454545455 2201 2.25848361021295e-07 942 1.2696115899753 -0.936485480336487 -1 7.64084155044234 2233 1106 2201 2542 1297 1043 942 4157 3277 3247 2116 2133 M11230 GO_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_VIRUS.html Reactions triggered in response to the presence of a virus that act to protect the cell or organism. 105/318 Gene Ontology BP GO:0051607 2.19043380517666e-08 4.0198356353499e-07 2615 1972 2202 1.99130347907795e-09 10 1.21313040288095 -1.16624692643991 -1 9.19136093027659 2615 760 2367 2937 10 1555 2202 1742 2946 2144 2414 2134 M16553 GO_SIALYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLATION.html The covalent attachment of sialic acid to a substrate molecule. 6/21 Gene Ontology BP GO:0097503 0.00951855909017786 0.0126632291850131 1315 2379.09090909091 2202 0.000955957792101562 588 1.84955840494846 -1.52785069628539 -1 4.15735951842653 1314 2526 4580 2575 3536 1630 588 2078 3832 2202 1309 2135 M16572 GO_LYSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. 6/16 Gene Ontology BP GO:0006553 7.63106295417617e-06 1.97497353936678e-05 3010 2342.63636363636 2203 7.63108915920762e-07 188 2.40811468052243 -3.41762885895226 -1 13.4203248429145 3010 2740 4583 1002 2192 3192 4258 188 562 2203 1839 2136 M12342 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that increases the frequency, rate or extent of cardiac muscle contraction. 6/16 Gene Ontology BP GO:0060452 0.000431619684410404 0.000691753605356405 1290 2214.27272727273 2204 4.31703540332479e-05 596 2.5038382077339 2.5038382077339 1 9.37298762589769 1287 3898 3892 2247 3750 1273 1251 837 2204 3122 596 2137 M13523 GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. 3/19 Gene Ontology BP GO:0006704 0.000939497100594638 0.00141718162380146 1675 2164.72727272727 2204 9.39894531753359e-05 11 3.32806253801357 3.32806253801357 1 11.2304483689633 1671 3057 4091 1241 3691 2712 2204 1797 11 2588 749 2138 M14056 GO_BLASTODERM_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTODERM_SEGMENTATION.html The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. 8/27 Gene Ontology BP GO:0007350 1.57443203737953e-05 3.63486372820953e-05 2475 2370.45454545455 2204 1.57444319225384e-06 611 1.68975151230641 1.76681839543814 1 8.88660925094763 2472 611 4177 1288 1920 2204 2054 4454 2502 2532 1861 2139 M12334 GO_FATTY_ACID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. 12/37 Gene Ontology BP GO:0055089 4.38053295884128e-05 8.72910494759658e-05 3320 2431.81818181818 2205 3.98238198573974e-06 1645 1.41269942567185 -0.98588512065999 -1 6.79281918435654 3318 1645 1830 1769 2205 1741 2139 4073 2375 3045 2610 2140 M11863 GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. 20/49 Gene Ontology BP GO:0051058 2.7169118017295e-06 8.80909322306569e-06 1625 2434.18181818182 2206 2.46992287001132e-07 1338 1.18311277520088 1.12432500641944 1 7.08485901929077 1622 1930 2206 2036 1338 3164 2676 1955 4046 3202 2601 2141 M13201 GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER.html The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. 9/16 Gene Ontology BP GO:0006390 0.00314147762450056 0.00441194210845616 1415 2465.36363636364 2206 0.000314592747724177 572 0.549553017710195 -0.549553017710195 -1 1.53336800637261 1412 2206 4031 3688 3545 985 572 1071 3616 4387 1606 2142 M10135 GO_METANEPHRIC_NEPHRON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. 10/29 Gene Ontology BP GO:0072273 4.38813386769195e-05 8.74050002046063e-05 4315 2537.09090909091 2207 3.98929217830079e-06 476 1.72198523170903 1.59448871469409 1 8.27883265711204 4311 476 1268 662 2207 4474 3807 4391 924 888 4500 2143 M11071 GO_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH.html Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). 653/1569 Gene Ontology BP GO:0008219 4.56960589468814e-07 2.78730492769333e-06 2210 2137.09090909091 2207 4.56960683434681e-08 660 1.61457691917559 1.80060958151039 1 10.6244489180404 1827 2942 3683 2581 660 3037 2206 2381 2207 838 1146 2144 M14965 GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 15/40 Gene Ontology BP GO:0061028 7.28014016710711e-05 0.000136462215566727 1060 2028.18181818182 2207 6.61852826305768e-06 795 1.307001625355 1.06959841295527 1 5.9841464042199 1057 2841 1669 2207 2355 844 795 4002 2807 2724 1009 2145 M10440 GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. 16/29 Gene Ontology BP GO:0045648 0.00196649507319284 0.00283114313948352 1680 2360.63636363636 2208 0.000178932277278696 1592 1.2742160787513 1.33987569814569 1 3.84615624297184 1679 2920 2120 2879 3053 2208 1592 1847 3549 2251 1869 2146 M10815 GO_PROTEIN_LOCALIZATION_TO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CILIUM.html A process in which a protein is transported to, or maintained in, a location within a cilium. 14/32 Gene Ontology BP GO:0061512 9.35962700854348e-05 0.000171183312983209 1615 2240.90909090909 2209 8.50911384179911e-06 1615 1.27030755863944 -1.44369982323726 -1 5.6679925980604 2209 1706 2846 2092 2415 1970 3209 2356 1615 2617 1615 2147 M12092 GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving guanosine-containing compounds (guanosines). 24/59 Gene Ontology BP GO:1901068 5.46556957192028e-06 1.50424656327361e-05 2110 2340 2209 4.96871195486747e-07 1095 0.861419334363963 -0.741452245719431 -1 4.92131429864583 2110 1095 3063 2912 1587 2164 2209 1249 3268 3798 2285 2148 M15004 GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. 38/80 Gene Ontology BP GO:0043666 0.000248527637307205 0.000416124709706943 1325 2328.09090909091 2209 2.25959742906057e-05 1060 1.6400560922949 1.72823269414776 1 6.56830260158138 1323 4030 2047 3181 2635 1790 1111 3147 2209 3076 1060 2149 M13410 GO_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 26/73 Gene Ontology BP GO:0042116 3.86947416598981e-06 1.14652000974414e-05 3215 2511.63636363636 2211 3.51770997439866e-07 1475 1.4640389912467 1.18118393528241 1 8.56864139807444 3212 2548 2211 1850 1475 3641 2899 2017 1769 2209 3797 2150 M15407 GO_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 479/1446 Gene Ontology BP GO:0009607 1.21309964247191e-08 2.40701779487055e-07 4500 2301.72727272727 2211 1.10281786287368e-09 210 1.6968126293492 -1.55759140430556 -1 13.3037129646796 4500 1051 210 1942 824 2557 4273 3412 2211 641 3698 2151 M11626 GO_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 444/1387 Gene Ontology BP GO:0050776 6.83197196223012e-07 3.44791802398201e-06 3985 2557.54545454545 2212 6.21088553078199e-08 561 1.65053152255195 -1.4346678910374 -1 10.6804310329355 3982 2212 561 1887 798 3094 4484 3954 2084 835 4242 2152 M15686 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. 26/69 Gene Ontology BP GO:0002711 0.00698152053560426 0.00944498830035273 1275 2176.90909090909 2212 0.000636706795929352 1004 1.4420256507248 -1.32896526998493 -1 3.4588577609634 1272 3314 2293 2689 3528 1004 1754 1215 3030 2212 1635 2153 M11963 GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 9/20 Gene Ontology BP GO:0051974 0.0016381816114272 0.00238734376078358 1195 2363.90909090909 2214 0.00016393905034057 438 3.15670416819779 3.15670416819779 1 9.80525028527602 1195 3477 3834 3323 3232 1991 1887 925 438 3487 2214 2154 M16905 GO_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_EFFECTOR_PROCESS.html Any process of the immune system that can potentially contribute to an immune response. 252/940 Gene Ontology BP GO:0002252 7.32727442541033e-08 1.00355560935635e-06 4600 2511.45454545455 2215 6.66115879041e-09 67 1.4330530816391 -1.16506545672781 -1 10.1830990942307 4600 1059 1619 1877 67 2367 4008 3848 2047 2215 3919 2155 M12013 GO_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. 21/47 Gene Ontology BP GO:0046513 1.49056026000707e-05 3.46900816401644e-05 1985 2385.09090909091 2216 1.355063962779e-06 1333 1.18690689981613 1.47996197598777 1 6.27060586966216 1981 1333 2141 2489 1870 2772 1879 3661 3260 2216 2634 2156 M12495 GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 916/2298 Gene Ontology BP GO:0044093 1.83149460151191e-07 1.73047531437208e-06 2260 1993.63636363636 2218 1.83149475245869e-08 304 1.55652335321517 1.65968138658855 1 10.6241565243262 1742 1303 3918 1359 304 3578 2464 2218 2259 529 2256 2157 M13524 GO_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of T cell proliferation. 84/232 Gene Ontology BP GO:0042129 4.01700461767466e-05 8.07750213939516e-05 3760 2633.36363636364 2220 3.65188906044225e-06 680 1.50670583502784 -1.32214522478896 -1 7.3049763677114 3759 1378 914 1368 2186 4545 3869 3496 2220 680 4552 2158 M15507 GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. 90/232 Gene Ontology BP GO:0030177 0.00367505646589889 0.0051287307397561 1885 2533.72727272727 2220 0.000334655451895564 1631 1.73935948925414 1.89024886003965 1 4.71846679050543 1882 3518 2251 1864 3160 4184 3346 2220 1631 1942 1873 2159 M14306 GO_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JNK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. 103/282 Gene Ontology BP GO:0046328 9.59388834870702e-07 4.27079804439565e-06 2225 2126.90909090909 2221 8.72172048406216e-08 933 1.63369532178779 1.75781509015278 1 10.3915950104628 1870 2944 1508 2346 933 2946 2092 2224 2504 1808 2221 2160 M15321 GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. 36/68 Gene Ontology BP GO:2001244 7.64723869486214e-06 1.97805734040362e-05 3320 2426.54545454545 2222 6.95205934266155e-07 491 1.68834556927235 -1.23260169003133 -1 9.40772523542114 3319 2217 2340 1933 1682 4242 2864 2222 491 1776 3606 2161 M13211 GO_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 43/128 Gene Ontology BP GO:0060191 2.09532878542097e-06 7.38984308651907e-06 4520 2635.54545454545 2223 1.90484616460112e-07 1156 2.18553896114938 -2.42338246991058 -1 13.2852425855092 4516 2541 1156 1699 1227 4291 4469 2223 1945 1214 3710 2162 M11354 GO_HYPEROSMOTIC_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPEROSMOTIC_RESPONSE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. 16/43 Gene Ontology BP GO:0006972 2.56578586000853e-07 2.05395581862407e-06 3075 2183 2224 2.33253287204321e-08 390 1.70583352264717 -1.43857633244714 -1 11.4928869923326 3072 2224 1658 1060 390 3895 3025 2160 2585 1144 2800 2163 M11931 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. 38/109 Gene Ontology BP GO:0034121 1.30592843618139e-05 3.09674449907567e-05 2185 2225.90909090909 2224 1.18721471662462e-06 1484 1.26557408619467 -1.36259521345238 -1 6.76012795863176 2183 2059 2354 2224 1837 1627 2861 1484 2420 3072 2364 2164 M14754 GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. 170/471 Gene Ontology BP GO:0034110 6.22837579520933e-06 1.67254764703048e-05 1625 2627.54545454545 2226 5.66217584391708e-07 498 1.62889762188714 -1.47280117704193 -1 9.21706480255069 3812 1602 498 1625 1623 3960 4499 3952 2226 521 4585 2165 M15143 GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 32/102 Gene Ontology BP GO:0060193 2.62591211390611e-06 8.61633211651312e-06 4400 2636 2226 2.3871956801733e-07 1325 2.41251449848693 -2.4426100365469 -1 14.474373846744 4398 2263 1596 2176 1325 4212 3778 2226 1399 1834 3789 2166 M10643 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. 11/31 Gene Ontology BP GO:2001014 2.84810877587222e-05 5.99173948635013e-05 3360 2421.27272727273 2227 2.58922331637401e-06 1528 1.56883291922216 -1.09728166666893 -1 7.84727581239852 3358 1714 1992 2439 2080 2227 3082 3576 1874 1528 2764 2167 M14914 GO_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 38/70 Gene Ontology BP GO:0010332 0.000371526223989753 0.000600625438016861 2720 2371.27272727273 2227 3.37808164113905e-05 1521 1.39570709057805 1.859568877708 1 5.32618689848531 2130 1897 1867 2227 2716 3350 2476 1521 1763 2718 3419 2168 M11398 GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of T cell proliferation. 53/158 Gene Ontology BP GO:0042102 4.76874037537046e-05 9.41780585403873e-05 4395 2566.63636363636 2230 4.33531249651405e-06 673 1.45361815179487 -1.07925539293986 -1 6.93278172261257 4391 1538 1100 1691 2230 4086 4384 1460 2413 673 4267 2169 M16739 GO_METANEPHROS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_MORPHOGENESIS.html The process in which the anatomical structures of the metanephros are generated and organized. 13/38 Gene Ontology BP GO:0003338 4.79703911726243e-05 9.46564072309795e-05 3930 2118.72727272727 2232 4.3610397441509e-06 593 1.89022450971642 -2.18596030473874 -1 9.0101742884331 3930 593 1084 612 2232 3406 3871 2586 868 864 3260 2170 M12515 GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 7/25 Gene Ontology BP GO:0070875 0.00164079517808288 0.00238965245038859 1520 2227.45454545455 2233 0.000164200793249833 832 1.68066172513284 2.20206549509689 1 5.21957942253682 1518 2767 3922 1587 3376 2233 2304 926 832 3278 1759 2171 M16813 GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS.html The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. 136/356 Gene Ontology BP GO:0045137 3.99011393207664e-07 2.61668064782936e-06 2570 2216 2234 3.62737695978097e-08 547 1.57616742282253 1.46681596629921 1 10.4229248087366 2569 1311 949 1697 547 3245 2781 4069 2234 1063 3911 2172 M14413 GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE.html The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. 10/36 Gene Ontology BP GO:0072661 0.0010577466960697 0.00157964551619544 2165 2153.81818181818 2236 9.62050542604251e-05 739 1.71809263850046 1.75055155979526 1 5.70172060056092 2162 2236 1373 1610 2938 2638 3650 2950 739 890 2506 2173 M14719 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. 6/27 Gene Ontology BP GO:2000136 0.000305101467283977 0.000501979487101171 3625 2391.54545454545 2236 3.05143364487442e-05 895 1.80412296001186 -1.29214926568553 -1 7.0512771577714 3624 1364 4281 1298 2695 2236 2716 1110 895 2194 3894 2174 M11570 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. 11/32 Gene Ontology BP GO:0002714 0.00102091556699947 0.00152808219780095 2240 2124.27272727273 2239 9.28536030426145e-05 824 1.42831692722678 -1.59134389452951 -1 4.76444759277264 2239 2895 2298 2990 3200 1409 1324 824 1722 2920 1546 2175 M10062 GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 25/50 Gene Ontology BP GO:0050856 2.63618993969285e-05 5.63268747813802e-05 4155 2714.81818181818 2240 2.39656502622484e-06 1006 2.08015275881366 -2.10217531070712 -1 10.4710215711881 4153 2019 1006 2240 2043 4640 3046 2635 2075 1603 4403 2176 M10581 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. 21/36 Gene Ontology BP GO:2000108 4.91000283945667e-05 9.65871151458919e-05 3475 2540.18181818182 2240 4.46373856843656e-06 565 2.18500724055645 -1.75153289027149 -1 10.3926236862243 3475 1336 1277 1382 2240 4599 3361 4367 565 1677 3663 2177 M14225 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. 11/32 Gene Ontology BP GO:0002891 0.000978298371875303 0.00147140892148268 2240 2125.81818181818 2240 8.89757885157102e-05 818 1.42831692722678 -1.59134389452951 -1 4.79221909802695 2240 2896 2299 2991 3201 1410 1325 818 1723 2934 1547 2178 M12740 GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 16/55 Gene Ontology BP GO:0032689 4.91152657461664e-05 9.65871151458919e-05 2640 2139.27272727273 2241 4.46512384406179e-06 1147 1.72493124401079 1.76329175738053 1 8.20434834134644 2640 2353 1194 1176 2241 2411 1345 4430 1661 1147 2934 2179 M15906 GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 12/38 Gene Ontology BP GO:0046473 5.82277246075384e-05 0.000112104119330838 2090 2084.81818181818 2241 5.29356961694765e-06 1037 1.79729076654428 -1.43827533164073 -1 8.41075648445866 2089 2438 2489 3018 2286 1333 1037 2241 1699 2362 1941 2180 M12301 GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 18/74 Gene Ontology BP GO:0070286 4.88108768787123e-05 9.61106451856918e-05 2400 2042.54545454545 2242 4.43745089706097e-06 367 1.4564627895524 -1.99906614359927 -1 6.93112810381351 2398 2594 2280 1505 2242 2057 3528 367 1156 3018 1323 2181 M10406 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 9/20 Gene Ontology BP GO:0038084 0.110122799652416 0.12377152233991 965 2586.90909090909 2243 0.0115993826685328 962 1.56574856945722 1.56574856945722 1 1.68301715658076 962 3504 3580 3041 4129 1927 1303 2243 3851 1905 2011 2182 M11409 GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. 892/2411 Gene Ontology BP GO:0009891 1.9680471828427e-07 1.78267484883277e-06 1970 2318.45454545455 2243 1.96804735713716e-08 329 1.59557186490418 1.76498545032113 1 10.8662892992691 1966 3238 3739 2809 329 3684 2857 2114 2243 788 1736 2183 M11910 GO_FOREBRAIN_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_REGIONALIZATION.html The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. 2/33 Gene Ontology BP GO:0021871 2.7733593760121e-05 5.8770915485277e-05 1795 2091.7 2245.5 3.08154840128031e-06 30 2.73142089975336 -2.73142089975336 -1 13.6896714747219 1795 2746 3821 NA 3702 2201 3095 319 30 2290 918 2184 M12479 GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. 22/76 Gene Ontology BP GO:0032651 0.0142602614056776 0.0185932023888125 2640 2302.36363636364 2246 0.00130486755747825 1323 1.43445487492796 1.57475580545792 1 2.9408504338285 2639 2101 1832 2292 3339 2878 1463 1944 3269 1323 2246 2185 M14203 GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epidermal cell differentiation. 30/67 Gene Ontology BP GO:0045604 1.13888136809284e-06 4.82906501557539e-06 4235 2541.09090909091 2246 1.035347234238e-07 976 2.30814242908265 -1.59794502006039 -1 14.5357289490016 4232 2218 1317 2246 994 3021 3344 3477 976 1631 4496 2186 M16394 GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. 11/24 Gene Ontology BP GO:0030826 7.74779861680836e-05 0.000144490397903981 3345 2282.18181818182 2247 7.04370135140935e-06 925 1.68460252128862 2.02594091659152 1 7.66345985790758 3473 1577 1328 925 2370 3343 2924 1754 1822 2247 3341 2187 M16095 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. 17/46 Gene Ontology BP GO:1903170 2.16974219396204e-06 7.59752263029601e-06 3700 2496.09090909091 2248 1.97249484896867e-07 583 1.21295900507057 -1.00574641549238 -1 7.35592142176836 3698 583 2248 804 1234 4256 3604 3511 1862 1804 3853 2188 M16062 GO_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_NUCLEUS.html A process in which a protein is transported to, or maintained in, a location within the nucleus. 89/234 Gene Ontology BP GO:0034504 0.000196338457019185 0.000335516914221596 1805 2264.27272727273 2249 1.78505437623548e-05 551 1.8034547857557 1.98424617669495 1 7.42247555263132 1804 4118 2249 3016 2755 2715 1915 551 1597 2895 1292 2189 M10278 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 27/52 Gene Ontology BP GO:0042771 5.81169941488958e-06 1.58448152573883e-05 4365 2479.54545454545 2250 5.28337706145954e-07 559 1.66750796252139 -0.890258183297864 -1 9.4819439991422 4364 567 2250 1231 1598 3783 4051 1220 559 3628 4024 2190 M10638 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. 129/330 Gene Ontology BP GO:0050688 5.10516387189991e-05 0.00010001382218241 2605 2210.90909090909 2251 4.64116576596231e-06 1200 1.61200466585494 -1.43822945772346 -1 7.63831869775101 2601 2423 1835 2979 2251 1200 2796 2328 1724 2213 1970 2191 M12546 GO_ER_NUCLEUS_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_NUCLEUS_SIGNALING_PATHWAY.html Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. 26/50 Gene Ontology BP GO:0006984 0.00012995663240075 0.000230125341051366 1785 2328.45454545455 2251 1.18149372481314e-05 490 1.58779469363878 1.94152033181382 1 6.84288561272177 1781 3037 2320 2482 3586 2251 1653 490 2126 3848 2039 2192 M16885 GO_LACTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATION.html The secretion of milk by the mammary gland. 23/88 Gene Ontology BP GO:0007595 3.28192536573131e-06 1.01518850586879e-05 3390 2418.81818181818 2252 2.98357296515103e-07 1404 1.70604814309742 -2.04802584503293 -1 10.0918388046831 3386 2912 1640 3111 1404 2171 3297 2029 2252 1439 2966 2193 M12702 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 12/37 Gene Ontology BP GO:0090281 5.1533378326e-05 0.000100872460188709 1410 2136.90909090909 2254 4.68496231790808e-06 1410 1.25769194051674 1.55831332103422 1 5.95391251116267 1410 1646 1975 2072 2254 2632 2455 1924 2486 2350 2302 2194 M14783 GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. 11/31 Gene Ontology BP GO:0034394 0.000667825972273181 0.00103495193233123 960 2197.45454545455 2254 6.07298892628057e-05 655 1.35558325402437 1.64643423216799 1 4.79358125113358 957 3978 2254 1582 3140 1280 1103 2957 3329 2937 655 2195 M14815 GO_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_FUSION.html The joining of two or more lipid bilayer membranes that surround a cell. 11/32 Gene Ontology BP GO:0045026 0.000398611756853127 0.000642399995511652 2155 2369.54545454545 2255 3.62439998647094e-05 1155 1.96732325718879 -1.96732325718879 -1 7.43948839430117 2152 3224 2255 2950 2730 1989 2660 1155 1829 2939 2182 2196 M10317 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 20/52 Gene Ontology BP GO:0050732 5.19675293522971e-05 0.000101593784750617 1565 2075.18181818182 2256 4.72443244993695e-06 721 1.38711274487881 -1.53641754449402 -1 6.56150573553021 1563 1001 2708 2588 2256 1501 2878 721 2919 3197 1495 2197 M11001 GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. 12/22 Gene Ontology BP GO:0042219 5.44080458965161e-06 1.50009832005656e-05 4260 2663.45454545455 2256 4.94619822301265e-07 907 1.47481261574479 -1.40725366242348 -1 8.42774486035578 4260 1712 2256 1645 1585 3423 4173 4230 907 1109 3998 2198 M15961 GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS.html The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 11/32 Gene Ontology BP GO:0021692 7.22038007755052e-05 0.000135396707189285 3305 2370.72727272727 2260 6.5641973278725e-06 1029 1.9069814240722 -1.37280133695068 -1 8.73886329632293 3304 2110 1029 1250 2351 2260 3392 4134 1293 1546 3409 2199 M12630 GO_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 57/139 Gene Ontology BP GO:0055076 3.65274046613219e-08 5.99281766227978e-07 3335 2157.18181818182 2262 3.32067320616363e-09 25 1.41335660062234 -1.21589986670024 -1 10.4180284888063 3334 894 2491 2396 25 1712 1793 3617 2262 1825 3380 2200 M13318 GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. 10/31 Gene Ontology BP GO:1901623 5.31475483678784e-05 0.000103525977353639 4385 2648.81818181818 2262 4.83171203168459e-06 879 1.84300953430352 1.85663954376035 1 8.70018621642697 4382 1285 933 879 2262 4131 4040 3994 1873 889 4469 2201 M11443 GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. 17/34 Gene Ontology BP GO:1901889 0.00106457573366591 0.0015890021466967 2325 2345.81818181818 2263 9.68264753689893e-05 1262 1.35913638038591 0.870000986039136 1 4.50634627052757 2321 1262 1515 1629 2940 2852 2263 3349 2203 1791 3679 2202 M16688 GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. 71/187 Gene Ontology BP GO:0034111 5.31565647234707e-05 0.000103525977353639 4595 2564.36363636364 2263 4.83253173998324e-06 479 1.86480088595738 -1.81331038964835 -1 8.80305538254615 4594 1741 479 1824 2263 3235 4154 3282 1819 513 4304 2203 M10673 GO_ENERGY_RESERVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_RESERVE_METABOLIC_PROCESS.html The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. 28/89 Gene Ontology BP GO:0006112 0.00136358769784115 0.00200733598004961 990 2127.81818181818 2264 0.000124039418252419 987 1.35995463848208 1.52111010740781 1 4.34554726718007 987 2145 2616 3210 2976 1313 1168 2264 2528 2416 1783 2204 M12134 GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 11/26 Gene Ontology BP GO:0071257 0.0659558376898935 0.0802918076544771 1950 2434.81818181818 2265 0.00618367091248451 1534 1.73063114419143 1.95152179329178 1 2.24557096460963 1949 2561 1696 3027 3565 2218 2417 2265 3663 1534 1888 2205 M16901 GO_FLUID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLUID_TRANSPORT.html The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 16/31 Gene Ontology BP GO:0042044 1.41415288534507e-05 3.30776415448723e-05 3420 2440.54545454545 2266 1.2856017959599e-06 391 2.73229859388704 -2.79900461214222 -1 14.5020481900384 3420 1004 391 1269 2389 3870 2256 3819 1924 2266 4238 2206 M11195 GO_VESICLE_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_TARGETING.html The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. 62/125 Gene Ontology BP GO:0006903 1.2565686555186e-05 3.0042473056503e-05 3465 2695.90909090909 2269 1.1423416660806e-06 1057 1.64868300629681 1.94624820210532 1 8.83224531570862 3465 2133 2192 2652 1816 4582 3573 2269 1057 1823 4093 2207 M12280 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. 3/15 Gene Ontology BP GO:1901722 9.5289276410761e-07 4.25002987872395e-06 4330 2128.27272727273 2270 9.52893172709934e-08 2 2.92582196717374 -0.859997863022034 -1 18.6178819402308 4330 350 3881 225 2270 3792 4078 63 2 2582 1838 2208 M10400 GO_PIGMENT_GRANULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_LOCALIZATION.html Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. 16/29 Gene Ontology BP GO:0051875 5.45428133786661e-05 0.000105737905017598 4595 2553.81818181818 2272 4.95856051466187e-06 474 1.87987738151847 2.18114148591807 1 8.85377981722086 4592 1492 2253 1392 2272 2885 4263 2462 474 1609 4398 2209 M10548 GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 11/33 Gene Ontology BP GO:0009261 0.00071377035450459 0.00110100855679894 2495 2242.09090909091 2272 6.49092760148179e-05 1211 1.53610304972701 1.783430526511 1 5.38303515763939 2492 1816 2272 2612 2848 3032 2170 1211 1409 2914 1887 2210 M10492 GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that stops or reduces the activity of a transporter. 43/102 Gene Ontology BP GO:0032410 4.02884617688672e-07 2.61980478260637e-06 2685 2159.81818181818 2273 3.66258810426088e-08 554 1.33026474938544 -1.27184472574213 -1 8.79599572562065 2682 785 2198 1481 554 3275 2667 3227 2273 967 3649 2211 M13934 GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 104/244 Gene Ontology BP GO:0046824 1.86268952744217e-05 4.19828518248252e-05 2275 2640.90909090909 2273 1.69336845326727e-06 1945 1.60527537425397 1.72522462379118 1 8.32332717435259 2273 3729 2237 3049 1945 2849 2173 2230 1976 3452 3137 2212 M15639 GO_CELLULAR_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 11/29 Gene Ontology BP GO:0071305 4.90426601343202e-05 9.65261004678459e-05 2205 2523.90909090909 2273 4.45852303938361e-06 989 1.85034837673194 1.64178232586904 1 8.80147572447919 2204 1985 1248 2273 2239 3594 3922 4145 2373 989 2791 2213 M12501 GO_METALLO_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLO_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. 14/22 Gene Ontology BP GO:0031163 5.4646479406441e-05 0.000105762235883329 1835 2495.09090909091 2274 4.9679851667658e-06 767 0.873657203422356 -0.940022832779083 -1 4.11461539597004 1835 3119 3098 3855 2274 1344 2189 767 3696 3779 1490 2214 M12835 GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. 12/27 Gene Ontology BP GO:2000369 5.71277871125572e-06 1.56171346247624e-05 1910 2088.09090909091 2274 5.19344867798422e-07 470 0.819022282335727 -0.728117661219282 -1 4.6633010263552 1908 470 2795 2274 1596 1243 2605 2742 3161 3050 1125 2215 M13758 GO_IRON_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. 14/22 Gene Ontology BP GO:0016226 5.4646479406441e-05 0.000105762235883329 1840 2499.90909090909 2275 4.9679851667658e-06 809 0.873657203422356 -0.940022832779083 -1 4.11461539597004 1836 3120 3099 3856 2275 1345 2190 809 3697 3781 1491 2216 M15452 GO_MONOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 103/276 Gene Ontology BP GO:0005996 5.7156957544799e-05 0.000110253325251559 2150 2329.72727272727 2276 5.19622205104069e-06 1159 1.48292337078078 -1.32122318547633 -1 6.95231617897441 2851 3106 2149 3199 2282 1159 2146 1992 2187 2276 2280 2217 M15783 GO_RESPONSE_TO_CYTOKINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CYTOKINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 393/1023 Gene Ontology BP GO:0034097 8.39461831580644e-07 3.90543214832558e-06 3340 2346.18181818182 2276 7.63147410815687e-08 589 1.6551158456633 1.84611911991515 1 10.6039991661692 3339 1305 589 1414 883 3408 4418 3152 2276 867 4157 2218 M15316 GO_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_LOCALIZATION.html A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. 32/79 Gene Ontology BP GO:0031503 0.0839184282471183 0.0949861682962873 1915 2641.54545454545 2277 0.00793650793650794 1911 1.36050213200866 1.46799076322833 1 1.64767700880487 1913 2657 2240 2742 4063 1911 1919 4439 2277 2712 2184 2219 M12958 GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA.html Any process of the innate immune response that takes place in the mucosal tissues. 16/97 Gene Ontology BP GO:0002227 0.0666714825927116 0.0811204648003039 835 2303.54545454545 2278 0.00625291694751714 831 1.74899838429143 -1.74899838429143 -1 2.26016431569244 831 2635 2182 2475 3566 1222 1273 2278 3559 3424 1894 2220 M14847 GO_DETERMINATION_OF_ADULT_LIFESPAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETERMINATION_OF_ADULT_LIFESPAN.html The control of viability and duration in the adult phase of the life-cycle. 9/19 Gene Ontology BP GO:0008340 5.0409379854239e-05 9.88389994354864e-05 2205 2334.45454545455 2278 5.04105233882574e-06 207 2.80751210469067 3.70547935644913 1 13.3201763684316 2202 2115 4303 2405 2278 3026 2901 2001 207 1919 2322 2221 M16497 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 367/874 Gene Ontology BP GO:0031400 8.84795788026596e-08 1.14751587815852e-06 1875 2162.90909090909 2278 8.04359839646643e-09 95 1.48797801696436 1.67487487460377 1 10.4707703289008 1873 3650 2434 2918 95 2571 1991 1431 2278 3031 1520 2222 M12231 GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that modulates the frequency, rate, or extent of immunoglobulin production. 34/86 Gene Ontology BP GO:0002637 0.0584646295792717 0.0715286627500813 1715 2384.81818181818 2279 0.0054616997894337 1268 1.80581215091487 -1.69933669830254 -1 2.45049042856108 1712 3629 2099 2959 3548 1268 1852 2279 2607 2431 1849 2223 M14040 GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. 10/27 Gene Ontology BP GO:0016242 1.33113643854287e-05 3.14848012437827e-05 2430 2267.81818181818 2280 1.2101313571019e-06 1120 1.10562143568021 -0.731827763024925 -1 5.89630824857196 2430 1120 2701 2280 1842 2261 1371 3834 1828 2829 2450 2224 M15313 GO_SCHWANN_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 20/42 Gene Ontology BP GO:0014037 5.59115382338012e-05 0.000108030491893275 890 2267.27272727273 2280 5.08299629445048e-06 890 0.951265907049924 0.969134563934678 1 4.46973992029862 890 2697 2651 3231 2280 1593 1650 1077 3720 3674 1477 2225 M13589 GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT.html The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 12/29 Gene Ontology BP GO:0034219 0.00061257843639417 0.000959258576788576 1345 2160 2281 5.57044611055772e-05 1244 1.89837191661922 2.39684298748768 1 6.78715526134454 1343 2069 1554 2462 2804 2281 1244 2692 2894 2355 2062 2226 M12810 GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION.html Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 11/20 Gene Ontology BP GO:0090129 2.35629257768313e-05 5.12664781545585e-05 1575 1997.90909090909 2282 2.14210710449692e-06 282 1.28818873729747 1.4838568890104 1 6.54683863801734 1573 2282 2357 2504 4037 859 761 282 3004 2930 1388 2227 M13674 GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-13 production. 20/65 Gene Ontology BP GO:0032656 0.0839184282471183 0.0949861682962873 2340 2372.54545454545 2282 0.00793650793650794 1396 1.91630096009507 -1.88876695224312 -1 2.32079457600234 1396 3254 1816 2340 4075 1746 2487 2338 2224 2140 2282 2228 M11752 GO_PURINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. 9/17 Gene Ontology BP GO:0043101 9.8584895115763e-05 0.00017908046479753 1465 1884.63636363636 2283 9.8589268930549e-06 334 0.854213589572262 0.856606370047978 1 3.7915997876753 1465 334 3800 2487 2451 723 567 2283 2583 2676 1362 2229 M14277 GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 27/56 Gene Ontology BP GO:0051353 3.16202869062106e-05 6.54830473262871e-05 4175 2782 2283 2.87461285356721e-06 620 2.3771770913913 -1.99052902539769 -1 11.7819689513266 4175 2266 1048 1334 2115 3934 4362 4110 620 2283 4355 2230 M10187 GO_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. 57/182 Gene Ontology BP GO:0006694 1.0030516379062e-06 4.41856618102322e-06 2545 2021 2284 9.1186554111854e-08 945 1.46867944920191 -1.36454118810808 -1 9.31626207091628 2543 1386 1863 2663 945 1192 3023 1269 2299 2764 2284 2231 M10799 GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. 32/65 Gene Ontology BP GO:1901185 2.37808734851747e-05 5.16922264005928e-05 1945 2573.18181818182 2284 2.16192095892093e-06 1715 1.84340535279779 2.1163718975004 1 9.36072034107803 1944 3311 2284 2278 2011 3172 2207 3392 1715 3525 2466 2232 M13549 GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. 20/70 Gene Ontology BP GO:0071622 0.000404272123825292 0.000650043112176188 2015 2296.54545454545 2286 3.67587665464591e-05 1133 1.60044122946546 -1.51287603502927 -1 6.042374749378 2015 2591 1417 2214 2733 2286 2120 3002 3130 1133 2621 2233 M10812 GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 108/272 Gene Ontology BP GO:0071216 3.82816126878127e-06 1.13645478075137e-05 2535 2453.45454545455 2287 3.48015266370793e-07 924 1.64679189004466 1.75104022711261 1 9.64571765490021 2531 2003 924 1553 1468 4182 3328 3489 2287 1807 3416 2234 M14802 GO_ACETYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. 7/12 Gene Ontology BP GO:0006085 0.0001897605687262 0.000325353885005814 805 2071.81818181818 2288 1.89776774756952e-05 167 1.35216424096504 -1.35216424096504 -1 5.58649694841681 802 2288 4295 3298 3133 362 167 560 3892 3292 701 2235 M10160 GO_CERAMIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. 6/13 Gene Ontology BP GO:0046514 0.000351371793720016 0.000570825485738991 790 1994.90909090909 2289 3.51427364048623e-05 627 1.07890321269499 -1.07890321269499 -1 4.14547084253935 627 2289 3546 2894 2722 788 786 1100 2603 3106 1483 2236 M10271 GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT.html The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. 9/31 Gene Ontology BP GO:0060973 3.57792465995393e-05 7.29450613807658e-05 4430 2675.90909090909 2289 3.57798226821127e-06 767 1.88112289421024 -1.80425191722128 -1 9.2189432893491 4429 1440 3561 1729 2180 3701 3833 2289 1243 767 4263 2237 M13218 GO_GALACTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. 5/16 Gene Ontology BP GO:0006012 5.35735007110005e-05 0.000104076051799655 3810 2508.36363636364 2289 5.35747923088147e-06 558 1.91580976379269 -1.73856903881052 -1 9.03862683658073 3808 1449 4034 1943 2289 2282 2490 3346 558 1090 4303 2238 M10228 GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 15/28 Gene Ontology BP GO:0022011 5.89739123779766e-05 0.000113428283003706 1070 2319.90909090909 2290 5.36140848282718e-06 1060 1.14473098653647 1.14473098653647 1 5.35006533152042 1067 2842 2565 3368 2290 1806 1855 1060 3728 3328 1610 2239 M12373 GO_GLYCOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 6/13 Gene Ontology BP GO:0019377 0.000351371793720016 0.000570825485738991 790 2028.63636363636 2290 3.51427364048623e-05 628 1.07890321269499 -1.07890321269499 -1 4.14547084253935 628 2290 3898 2895 2723 789 787 1094 2604 3123 1484 2240 M14616 GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT.html The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 15/28 Gene Ontology BP GO:0032292 5.89739123779766e-05 0.000113428283003706 1070 2316.36363636364 2291 5.36140848282718e-06 1002 1.14473098653647 1.14473098653647 1 5.35006533152042 1068 2843 2566 3369 2291 1807 1856 1002 3729 3338 1611 2241 M11419 GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. 15/39 Gene Ontology BP GO:0043508 2.92644207495622e-05 6.13706890425553e-05 2365 2215.54545454545 2294 2.66043727567387e-06 301 3.19423740076906 3.19423740076906 1 15.938139734462 2364 3373 2220 3748 2597 2294 1318 301 409 3807 1940 2242 M12148 GO_POLYSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 12/33 Gene Ontology BP GO:0000272 0.00880997645210148 0.0117813135561945 1580 2512.27272727273 2294 0.000804132306929805 1274 1.51363160445636 1.9642818016064 1 3.45849132147252 1578 3096 2684 3446 3965 2038 2294 1274 2195 3044 2021 2243 M13756 GO_VESICLE_COATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COATING.html A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. 56/116 Gene Ontology BP GO:0006901 8.70410482762977e-06 2.19995420330348e-05 4615 2765.45454545455 2294 7.91285387712644e-07 980 1.80234595231719 2.0479846751357 1 9.94436599902804 4613 2091 1974 2517 1716 3663 4615 2294 980 1779 4178 2244 M13207 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS.html Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 19/38 Gene Ontology BP GO:0036003 5.97298491273027e-05 0.000114550057620019 2330 2136.36363636364 2295 5.43013371365929e-06 589 2.07536723632992 2.28123988517782 1 9.68902182193972 2327 2839 1513 1597 2295 3236 2983 1481 589 2021 2619 2245 M10070 GO_APICAL_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, apical regions of the cell. 11/30 Gene Ontology BP GO:0045176 0.000394905586199073 0.000636869272915004 2860 2408 2298 3.59069536885176e-05 956 2.14978388048687 -1.08768469619559 -1 8.13903188945602 2860 2959 2049 2161 2728 3155 1767 3332 956 2223 2298 2246 M14655 GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. 8/19 Gene Ontology BP GO:0006646 5.46037075040462e-05 0.000105762235883329 4145 2660.27272727273 2298 5.46050492546402e-06 582 2.12569263092483 -2.59414721370331 -1 10.0112603634838 4144 2173 4267 1607 2298 3531 4029 1350 582 1058 4224 2247 M16706 GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. 116/236 Gene Ontology BP GO:2001235 1.68113570459069e-06 6.3100348232939e-06 2225 2280.36363636364 2298 1.52830635385115e-07 1144 1.515824802162 1.65882410985597 1 9.3374378388456 2221 2298 2536 2379 1144 3260 1851 2977 1719 2575 2124 2248 M10689 GO_PHOTOPERIODISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOPERIODISM.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. 15/67 Gene Ontology BP GO:0009648 6.44209732161411e-05 0.000122484266438388 2725 2107 2299 5.8566236077455e-06 712 2.11303982570669 -1.15257352492963 -1 9.79209550095092 2724 2403 1459 2336 2320 1533 3403 2299 712 2110 1878 2249 M11199 GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX.html The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. 5/18 Gene Ontology BP GO:0021819 3.25644133059331e-06 1.00999713413124e-05 70 1875.90909090909 2300 3.25644610258771e-07 66 0.947524759191913 0.947524759191913 1 5.60742066617702 882 2742 3706 2300 3278 514 66 340 3765 2975 67 2250 M15696 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. 12/30 Gene Ontology BP GO:0015012 7.04059122095706e-05 0.000132399615386406 2000 2170.72727272727 2300 6.40074231717491e-06 828 1.64221243888177 0.635103749528551 1 7.54445430603816 1999 1767 2540 3101 2343 1357 828 2616 1322 3705 2300 2251 M12567 GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. 10/24 Gene Ontology BP GO:2000269 3.35161641902608e-05 6.87651570196115e-05 2870 1940.45454545455 2301 3.04697043701634e-06 97 2.40661313312227 3.29145273207875 1 11.8673102175481 2301 2867 2093 2868 2676 2673 1013 318 97 2820 1619 2252 M13389 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 16/54 Gene Ontology BP GO:0030813 0.0663804708988634 0.0807875560638068 1960 2529.90909090909 2301 0.00622475273949896 1308 1.1397979158045 1.01925290325468 1 1.47532850335253 1959 2792 1668 2301 4397 1308 1402 2880 3893 3426 1803 2253 M14743 GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. 46/129 Gene Ontology BP GO:0002702 0.00171522005918223 0.00249257174797593 2270 2430.81818181818 2301 0.000156050798563854 1641 1.79589592050878 -1.64223111546883 -1 5.53849900762792 2266 3627 1641 2226 3028 1655 2926 2594 2301 2147 2328 2254 M15310 GO_ENDOPLASMIC_RETICULUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. 21/47 Gene Ontology BP GO:0007029 2.47433005512246e-05 5.34340206787607e-05 2305 2563.54545454545 2304 2.24941625839902e-06 1098 1.25596854843374 -0.800070715217116 -1 6.35633110132118 2304 2950 2906 3858 2020 1098 1581 4266 1927 3715 1574 2255 M13109 GO_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ADAPTATION.html A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 22/50 Gene Ontology BP GO:0043500 0.000475028716701155 0.000757143265239774 2550 2373.36363636364 2305 4.31937560851429e-05 816 2.61097177054501 3.48410096854393 1 9.65270852382002 2546 2268 816 1634 2761 3492 3452 2031 1328 2305 3474 2256 M13722 GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 59/172 Gene Ontology BP GO:0010906 1.77594335979234e-05 4.03410226003711e-05 2305 2550.63636363636 2305 1.61450699654867e-06 1925 1.43979048117814 1.53098251993182 1 7.49484006483377 2160 2305 2148 3081 1925 3824 2746 2304 2658 2275 2631 2257 M13060 GO_SUBSTANTIA_NIGRA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTANTIA_NIGRA_DEVELOPMENT.html The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). 44/111 Gene Ontology BP GO:0021762 1.22304845834914e-05 2.9377206374108e-05 2410 2302.36363636364 2306 1.11186841609911e-06 1033 2.35540805466523 2.54657938354252 1 12.6454152511061 2407 2306 1608 1961 1808 3193 2981 1892 1033 2727 3410 2258 M15547 GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. 19/53 Gene Ontology BP GO:0045414 4.39054288634452e-06 1.26616711933525e-05 2795 2317.72727272727 2306 3.99141058961927e-07 771 1.50372994132894 -2.27446823183464 -1 8.72414961954225 2793 2953 2306 2348 1514 2301 3401 771 1881 3083 2144 2259 M12846 GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. 29/60 Gene Ontology BP GO:0042398 1.48931410233185e-05 3.46784622724513e-05 3485 2420.18181818182 2308 1.35393107682035e-06 673 1.38904926889052 -1.31075938778439 -1 7.33879379198399 3483 673 2308 1721 1869 3016 4389 2176 2040 2460 2487 2260 M16775 GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 13/17 Gene Ontology BP GO:0010839 2.97332848656315e-05 6.2157425317932e-05 1210 2349.72727272727 2309 2.70306242931182e-06 1208 1.4909246701384 1.74289825777462 1 7.42942697981799 1208 2230 2309 3343 2093 2637 2606 2940 2679 1858 1944 2261 M13986 GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. 28/88 Gene Ontology BP GO:0043471 0.00600476627902298 0.00817599115352015 1605 2499.54545454545 2310 0.000547383529704294 1186 1.05820100992045 0.964238183906561 1 2.61676107302137 1604 2310 2350 3004 3236 2138 2074 1186 3789 3881 1923 2262 M10481 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. 5/19 Gene Ontology BP GO:2001028 0.0127994032714104 0.0167685184506655 2085 2545.36363636364 2311 0.00128737276034518 1084 1.43775813383563 1.40696471444856 1 3.02402702538348 2085 3482 3595 3350 4121 2311 1577 1387 3681 1084 1326 2263 M11152 GO_RESPONSE_TO_MORPHINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MORPHINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. 16/40 Gene Ontology BP GO:0043278 0.00337974803371239 0.00473368631086776 1335 2276.27272727273 2311 0.000307722851191567 461 1.79721269079185 2.28124353240923 1 4.94952048200623 1331 4297 2595 2831 4030 1093 461 1721 2311 3420 949 2264 M12009 GO_DECIDUALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DECIDUALIZATION.html The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. 12/25 Gene Ontology BP GO:0046697 0.000319785516304444 0.000524281127189808 2315 2093.63636363636 2311 2.90756371678313e-05 861 2.04068208525626 -2.39968000991547 -1 7.93021388924094 2311 2163 861 2799 2685 2033 3207 1116 2338 1111 2406 2265 M13291 GO_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 22/76 Gene Ontology BP GO:0042446 0.000185237605950288 0.000318068862584019 1750 2347.72727272727 2311 1.6841200417628e-05 1180 1.651490222196 -1.2323471432416 -1 6.84241006489554 1749 3065 2311 2758 2571 1180 1932 1765 2222 3735 2537 2266 M16356 GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. 28/88 Gene Ontology BP GO:0043470 0.00600476627902298 0.00817599115352015 1605 2522.72727272727 2311 0.000547383529704294 1429 1.05820100992045 0.964238183906561 1 2.61676107302137 1605 2311 2351 3005 3237 2139 2075 1429 3790 3884 1924 2267 M10782 GO_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDLIMB_MORPHOGENESIS.html The process in which the anatomical structures of the hindlimb are generated and organized. 16/54 Gene Ontology BP GO:0035137 6.24642017253658e-05 0.000119252174593287 3400 2649.81818181818 2312 5.67872503005804e-06 1597 1.65074084346132 -1.60478214485907 -1 7.67245393834507 3400 2065 1597 1754 2312 4208 3045 3071 2193 1612 3891 2268 M13034 GO_MULTIVESICULAR_BODY_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 22/34 Gene Ontology BP GO:0036257 0.000285324522907691 0.000471613300057105 1020 2205.54545454545 2312 2.59419576555786e-05 208 0.93748441192154 -0.68595719674095 -1 3.69418170515873 1017 2312 2871 3166 4419 254 208 2248 3461 3320 985 2269 M16195 GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. 16/40 Gene Ontology BP GO:0014072 0.00337974803371239 0.00473368631086776 1335 2271.36363636364 2312 0.000307722851191567 462 1.79721269079185 2.28124353240923 1 4.94952048200623 1332 4298 2596 2832 4031 1094 462 1645 2312 3433 950 2270 M10177 GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. 14/37 Gene Ontology BP GO:1904030 4.56490108688948e-05 9.049887167561e-05 3510 2541.36363636364 2313 4.14999619026024e-06 1307 1.81145362647315 -0.963001927399267 -1 8.67655468840798 3510 2636 1745 2313 2219 2183 1858 3510 1307 2616 4058 2271 M15088 GO_REVERSE_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REVERSE_CHOLESTEROL_TRANSPORT.html The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. 8/24 Gene Ontology BP GO:0043691 0.000654619371818078 0.00101652098439844 2315 2517.09090909091 2313 6.54812288739625e-05 1431 2.37043462627506 2.3644680411261 1 8.40418939923305 2313 1989 4347 1431 2852 3448 3349 2945 1488 1755 1771 2272 M10721 GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase C activity. 17/64 Gene Ontology BP GO:1900274 3.79592830022355e-06 1.1305000062821e-05 2620 2393.90909090909 2314 3.45084986347036e-07 847 2.48770901689009 -2.61306276539319 -1 14.5779275814633 2619 2634 847 2238 1465 3074 2314 3969 1888 1231 4054 2273 M12226 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 38/71 Gene Ontology BP GO:1902041 1.2860178518044e-05 3.06047200713881e-05 3880 2776.18181818182 2314 1.16911397211743e-06 1545 1.18263400593813 -0.984364064873392 -1 6.32426792284146 3879 1545 2109 2277 1826 2052 3882 4617 3093 2314 2944 2274 M16219 GO_SINGLE_ORGANISM_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CATABOLIC_PROCESS.html A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism. 493/1233 Gene Ontology BP GO:0044712 2.79533772034983e-07 2.15487069452492e-06 4590 2467.27272727273 2317 2.54121643229795e-08 390 1.68808822191082 -1.43529454111462 -1 11.3316749508147 4588 1137 390 2795 410 2317 3974 4332 2009 1154 4034 2275 M14083 GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of plasma membrane organization. 60/137 Gene Ontology BP GO:1903729 1.11936347374471e-06 4.76370724894289e-06 3975 2477.36363636364 2318 1.0176036757082e-07 257 1.44231088204895 -1.286677604024 -1 9.09318977070521 3971 257 1812 973 986 3553 4321 4214 1703 2318 3143 2276 M16339 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 28/52 Gene Ontology BP GO:0070059 0.000115545917379898 0.000206576701730792 1660 2374.54545454545 2318 1.05047260362215e-05 1289 1.11756825883486 1.134988487341 1 4.87842818666609 1660 2892 2318 3362 2465 1605 1289 1903 3538 3682 1406 2277 M10684 GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 64/190 Gene Ontology BP GO:0032649 5.25590724567496e-05 0.000102534358578441 3170 2241.81818181818 2319 4.77821165096468e-06 1067 1.63678428985041 -1.73184836785572 -1 7.73477541259545 3166 2457 1067 1770 2258 2319 3239 1859 2503 1330 2692 2278 M13761 GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell. 14/55 Gene Ontology BP GO:0042491 0.000140624820135314 0.0002470378508847 4025 2276 2320 1.27848917937014e-05 373 1.80640397613483 -1.71548121555033 -1 7.71911487777706 4021 1804 1585 883 2511 2402 2320 3185 373 1392 4560 2279 M10218 GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of leukocyte proliferation. 118/335 Gene Ontology BP GO:0070663 8.68329621463276e-06 2.19828485957142e-05 3710 2500.45454545455 2321 7.89393680671151e-07 565 1.50141608254968 -1.24604369705739 -1 8.28458450526276 3709 1373 791 1450 1714 4167 4011 2885 2321 565 4519 2280 M14008 GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. 65/154 Gene Ontology BP GO:2000117 2.91936463049959e-05 6.12776219683977e-05 1865 2579 2321 2.65400306428963e-06 1732 1.46177911524521 1.7168870383942 1 7.29491256302479 1865 4083 2321 3542 2088 2092 1732 2546 3013 2888 2199 2281 M16118 GO_IMMUNOLOGICAL_SYNAPSE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE_FORMATION.html The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 21/51 Gene Ontology BP GO:0001771 3.85671601209017e-06 1.14346950473401e-05 1765 2398.81818181818 2321 3.50611161193937e-07 1181 1.26581140746289 -0.681958736268236 -1 7.41020141530707 1763 3248 2126 3378 1474 1898 1181 2321 3214 3259 2525 2282 M11774 GO_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSPORT.html The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. 17/32 Gene Ontology BP GO:0006862 3.41741815957183e-05 6.99606371908819e-05 2830 2279.90909090909 2322 3.10679204176308e-06 582 1.01700122128042 -0.67529576188881 -1 5.00594119866205 2826 582 2698 1728 2144 2906 1395 3116 1968 2322 3394 2283 M14197 GO_CELLULAR_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 13/32 Gene Ontology BP GO:0036315 0.000152017817665043 0.00026464894166434 4030 2380.18181818182 2323 1.38207566328844e-05 842 1.36707798221393 -1.5797620994078 -1 5.7933564365913 4027 842 2031 2323 2532 2259 3527 1377 3150 1253 2861 2284 M11118 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS.html A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. 8/27 Gene Ontology BP GO:0002087 1.18568583108689e-05 2.86278695462113e-05 2325 2207.09090909091 2324 1.18569215746341e-06 747 1.40634400890863 1.24541059200418 1 7.56889493801612 2324 1294 3694 2704 1835 1955 747 2782 2573 1730 2640 2285 M12036 GO_ASYMMETRIC_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_CELL_DIVISION.html The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. 11/19 Gene Ontology BP GO:0008356 0.000107341812845975 0.000193398539791953 1630 2096.72727272727 2324 9.75882278153141e-06 509 1.30778305910085 1.43298292770769 1 5.753108763767 1630 3405 2722 2360 2449 1526 1468 1745 2324 2926 509 2286 M13321 GO_REGULATION_OF_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 10/23 Gene Ontology BP GO:0044030 1.21631441614695e-05 2.92457163861745e-05 1770 2213.72727272727 2325 1.10574649167165e-06 216 1.31222613851791 -1.31222613851791 -1 7.04794058172989 1768 2325 2375 3069 3534 1156 1631 216 3209 3583 1485 2287 M12246 GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an external stimulus. 522/1381 Gene Ontology BP GO:0032101 6.10829472876096e-07 3.23212152206309e-06 1995 2076.90909090909 2327 6.1082964077685e-08 358 1.58089509367963 1.73244170133812 1 10.2823871679237 1993 358 3875 1119 790 3579 2576 3100 2327 373 2756 2288 M12936 GO_RESPONSE_TO_ISCHEMIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISCHEMIA.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. 23/46 Gene Ontology BP GO:0002931 6.58114585004382e-05 0.000124617700578114 2235 2389.18181818182 2328 5.9830388442327e-06 1435 1.29550098818895 -1.12649802237663 -1 5.99200665101457 2235 2432 2418 2447 2328 1930 2261 4058 3105 1435 1632 2289 M15711 GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. 9/18 Gene Ontology BP GO:0060055 0.000784304908321983 0.00120023984487112 995 2097.45454545455 2329 7.84581856284401e-05 694 1.18405763236264 1.36643219808042 1 4.09677835136983 991 2329 4445 2468 3095 904 694 1069 3668 2699 710 2290 M11165 GO_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of exocytosis. 90/250 Gene Ontology BP GO:0017157 7.74652394832346e-07 3.70413086427042e-06 4480 2407.18181818182 2330 7.04229697817269e-08 764 1.4154150173341 1.43462497157761 1 9.1068190254779 4479 764 1804 1651 855 3006 4077 3186 2330 994 3333 2291 M14172 GO_ZINC_II_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_II_ION_TRANSPORT.html The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 10/27 Gene Ontology BP GO:0006829 0.00422781280500152 0.00586662727245131 3590 2526.90909090909 2330 0.000385087223563323 937 1.71370050351992 1.85356303270891 1 4.53034687766418 3587 937 2123 1992 3179 3708 2330 2845 1468 2075 3552 2292 M15506 GO_CEREBRAL_CORTEX_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_CELL_MIGRATION.html The orderly movement of cells from one site to another in the cerebral cortex. 17/66 Gene Ontology BP GO:0021795 0.010822470117066 0.0142711527275029 2335 2473.63636363636 2333 0.000988734428475775 1414 1.28926475820917 1.25473570626105 1 2.81866614453758 2457 1933 1784 2333 3310 3636 2664 1414 3053 2332 2294 2293 M15291 GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of macrophage differentiation. 12/25 Gene Ontology BP GO:0045649 6.61163052205284e-05 0.000125143907516883 3240 2294 2334 6.0107538444177e-06 862 1.68229405688518 -1.71705322561525 -1 7.77737210229614 3236 2358 862 2068 2329 2334 2376 2065 3196 1662 2748 2294 M15584 GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. 10/16 Gene Ontology BP GO:0070234 6.83649058816193e-05 0.00012903181219852 3700 2432.18181818182 2335 6.21518458277936e-06 309 2.53315423618482 -1.94757158737775 -1 11.6710914993808 3699 1204 1033 1592 2335 3465 3408 4287 309 1378 4044 2295 M10174 GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST.html Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. 6/28 Gene Ontology BP GO:0044144 0.000496709011275841 0.000789801349093743 2340 2375.63636363636 2336 4.96820070143441e-05 855 1.83493894432319 -1.83493894432319 -1 6.74386549834754 2336 1774 3549 2374 2788 2114 3563 855 2036 3107 1636 2296 M15735 GO_COLLECTING_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLECTING_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. 5/27 Gene Ontology BP GO:0072044 2.94355630992564e-05 6.15904999864117e-05 3595 2374.09090909091 2336 2.94359530100941e-06 43 2.76585080483611 -2.01178508271945 -1 13.79555109339 3592 2416 4450 1125 2126 2336 2584 2198 43 1097 4148 2297 M16454 GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 72/204 Gene Ontology BP GO:0032479 6.86015325860704e-05 0.000129425808938287 2040 2226.72727272727 2336 6.23669744070614e-06 464 1.05565767191926 -1.17978306633112 -1 4.86211226887131 2039 3084 3314 3603 2336 464 1372 521 3212 3911 638 2298 M13270 GO_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of chemokine production. 48/124 Gene Ontology BP GO:0032642 2.05725058119204e-06 7.29703166422814e-06 2940 2421.81818181818 2337 1.87022954996197e-07 1219 1.57454461019873 1.49268957567208 1 9.58142706200945 2940 1838 1401 1704 1219 3428 2518 3657 2337 2271 3327 2299 M13818 GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. 12/21 Gene Ontology BP GO:0031293 0.0162829213096787 0.0211354776742628 2340 2215.63636363636 2337 0.00149133638996837 1131 1.44326328437781 -1.10550731432631 -1 2.86374993743217 2337 1574 2382 1993 3361 1617 1357 3274 1131 2357 2989 2300 M12663 GO_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a lymphocyte. 63/369 Gene Ontology BP GO:0002449 1.18121201216533e-07 1.34751041092964e-06 4240 2480.18181818182 2338 1.07382915962394e-08 144 1.26863762461763 -1.00759401453044 -1 8.82243204142734 4236 403 2338 2008 144 2312 3875 2397 2230 2765 4574 2301 M16030 GO_MATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING_BEHAVIOR.html The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. 9/27 Gene Ontology BP GO:0007617 6.34804438888027e-05 0.00012099330910333 3935 2717.36363636364 2338 6.34822573567527e-06 707 2.76033594552124 2.5017934164139 1 12.8091412842044 3931 1817 4496 1488 2338 2740 1656 4350 707 1931 4437 2302 M16592 GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species. 9/27 Gene Ontology BP GO:0044705 6.34804438888027e-05 0.00012099330910333 3935 2727.63636363636 2339 6.34822573567527e-06 708 2.76033594552124 2.5017934164139 1 12.8091412842044 3932 1818 4588 1489 2339 2741 1657 4357 708 1937 4438 2303 M11936 GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 48/142 Gene Ontology BP GO:0019217 7.86147207409522e-05 0.000146120155484484 1725 2355.81818181818 2341 7.14704819064519e-06 1724 1.67044677037082 1.7626937926107 1 7.58942442181385 1724 2341 1943 1805 2375 3043 2668 2067 2530 3609 1809 2304 M13200 GO_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of B cell differentiation. 16/36 Gene Ontology BP GO:0045577 0.000326019651239615 0.000532996211516033 1115 2025.27272727273 2343 2.96425431238349e-05 621 1.45592821904462 -1.45592821904462 -1 5.64547574668242 1111 2859 2343 3175 2791 852 887 621 3675 2851 1113 2305 M13232 GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. 29/68 Gene Ontology BP GO:0033628 1.32848083183835e-06 5.39644488383681e-06 3040 2406.18181818182 2343 1.20771057640793e-07 1051 1.82843820192088 -1.78995531158764 -1 11.410251256426 3039 2343 1361 1235 1051 3626 2519 4052 1853 1564 3825 2306 M11624 GO_RESPONSE_TO_MURAMYL_DIPEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MURAMYL_DIPEPTIDE.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. 12/24 Gene Ontology BP GO:0032495 0.00292724153474682 0.00413231451682259 4065 2730.63636363636 2344 0.000266467608069178 1223 1.85842346903228 -1.13800723350582 -1 5.24799807801907 4064 1937 1855 1753 3117 2830 2169 4499 1223 2344 4246 2307 M11628 GO_MEMBRANE_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. 8/24 Gene Ontology BP GO:0046466 0.000378929168405987 0.000612380135366863 1530 2475.63636363636 2344 3.78993798208534e-05 1529 1.0541846462577 -1.07890321269499 -1 4.01238391290959 1529 2412 3777 2850 2736 1953 2050 1878 2344 3374 2329 2308 M12325 GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. 4/31 Gene Ontology BP GO:0021895 0.0013489663197232 0.00198770251427318 2255 2473.45454545455 2344 0.00013497858895648 892 1.69379145427173 -1.69379145427173 -1 5.42084221755958 2252 3988 3891 2344 4175 1463 1667 892 2493 2780 1263 2309 M13548 GO_BLASTOCYST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_DEVELOPMENT.html The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. 28/76 Gene Ontology BP GO:0001824 7.05704433528078e-05 0.00013265529088546 2345 2331.81818181818 2344 6.41570065236844e-06 647 0.983912037589077 -1.11774892841692 -1 4.51919276418699 1904 2344 2837 3354 2344 833 1327 2640 3742 3678 647 2310 M10343 GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. 32/89 Gene Ontology BP GO:1904035 1.58117145462674e-06 6.06541094703108e-06 4270 2590.36363636364 2345 1.43742962821674e-07 669 1.50939522429359 -1.35647847938863 -1 9.32853545988233 4402 669 887 1136 1112 4266 4245 4269 2345 1072 4091 2311 M11201 GO_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DETERMINATION.html Any process that establishes and transmits the specification of sexual status of an individual organism. 5/29 Gene Ontology BP GO:0007530 6.4608624375202e-05 0.000122790766669694 3465 2592.63636363636 2345 6.46105028755231e-06 821 2.16072638056138 -2.79141345529703 -1 10.0103028629445 3463 2294 3707 1454 2345 4078 4396 1141 821 1964 2856 2312 M11761 GO_AXON_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_REGENERATION.html The regrowth of axons following their loss or damage. 12/34 Gene Ontology BP GO:0031103 0.00392638394819644 0.00546141422153268 4190 2683.72727272727 2345 0.000357582636654619 854 1.79573884396502 -2.00257118935455 -1 4.81334644690731 4188 1860 2054 1879 3174 4296 2945 1512 854 2345 4414 2313 M11983 GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. 23/44 Gene Ontology BP GO:0006778 6.48720353814073e-05 0.000123234360371041 3660 2394.54545454545 2345 5.89763166916571e-06 515 2.05457734853001 2.68425683701162 1 9.51471941616703 3657 2219 2345 1536 2321 2915 4289 1098 515 2897 2548 2314 M14156 GO_DRUG_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_METABOLIC_PROCESS.html The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. 15/89 Gene Ontology BP GO:0017144 3.12768450027411e-05 6.49165808438654e-05 2665 2374.72727272727 2345 2.84338996969151e-06 579 2.71566610905971 -1.8774375338474 -1 13.4717561084646 2663 2437 579 1425 2109 3597 4069 2345 2521 2119 2258 2315 M16552 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 6/18 Gene Ontology BP GO:0010661 0.000792976072867354 0.00121231080221374 2410 2275.54545454545 2345 7.93259180032722e-05 362 2.98334036747334 -2.98334036747334 -1 10.3068473478886 2408 2647 4579 1329 3514 2345 2266 1708 362 3159 714 2316 M12293 GO_ANDROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 10/34 Gene Ontology BP GO:0006702 0.00558938090057063 0.00765530841337741 2075 2850.54545454545 2348 0.000509421104747233 1156 2.79141345529703 -2.79141345529703 -1 6.99721929996035 2072 4170 2348 3938 4236 2125 2313 1156 3272 3573 2153 2317 M15944 GO_ARACHIDONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. 16/110 Gene Ontology BP GO:0019369 0.000855541507953355 0.00130025506429703 1720 2230.09090909091 2349 7.78067631205615e-05 1126 2.18610238503656 -2.25365908274567 -1 7.47378382280671 1718 3040 1126 3198 2891 2144 2411 1395 2637 1622 2349 2318 M14819 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. 29/70 Gene Ontology BP GO:1903201 2.89674652186207e-06 9.24370728591449e-06 2425 2255 2350 2.6334093963853e-07 1362 1.37706179862204 -1.00450420943254 -1 8.21216987187625 2425 2853 2655 2350 1362 2216 1640 1445 3172 2893 1794 2319 M15058 GO_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. 7/19 Gene Ontology BP GO:0046339 6.55520762919056e-05 0.00012438017581664 3535 2717.45454545455 2350 6.55540100558066e-06 790 2.18798310549517 1.71843204907954 1 10.1221019014945 3533 1663 4342 2069 2350 4367 3686 2128 790 1508 3456 2320 M11732 GO_ANATOMICAL_STRUCTURE_ARRANGEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_ARRANGEMENT.html The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 14/39 Gene Ontology BP GO:0048532 0.000247939663573169 0.000415439862132885 2355 2078 2351 2.25425100677215e-05 585 1.98178739628674 -1.10954056305048 -1 7.93859076820168 2351 2667 1035 1411 3175 2692 2823 585 2090 2620 1409 2321 M12871 GO_PROTEIN_LOCALIZATION_TO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMATIN.html Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. 12/19 Gene Ontology BP GO:0071168 0.00459547573941176 0.00635970010673287 2720 2668.72727272727 2351 0.000418645743373379 1121 1.59538507960611 -1.61099697530335 -1 4.15132932656867 2718 3442 2322 3402 3758 2215 2199 1121 3533 2351 2295 2322 M14131 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. 10/23 Gene Ontology BP GO:1903019 0.0138624127309919 0.0180947940146178 1075 2418.27272727273 2352 0.00126823086679109 745 1.24717024239523 -1.24717024239523 -1 2.57432263074634 1074 3045 2352 3562 3701 816 745 2210 4176 3586 1334 2323 M16771 GO_INTESTINAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_ABSORPTION.html Any process in which nutrients are taken up from the contents of the intestine. 17/58 Gene Ontology BP GO:0050892 1.2483093806353e-05 2.98911833640521e-05 3070 2430.72727272727 2352 1.13483314887791e-06 793 2.38530260637468 2.00462241626031 1 12.7846246503913 3070 2352 793 1082 1813 4319 4631 2949 838 1241 3650 2324 M13330 GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. 12/61 Gene Ontology BP GO:0006775 0.00114266043634573 0.00169880640600488 2495 2159.90909090909 2353 0.000103932214175203 846 1.92670255119017 -2.36887738435558 -1 6.32193268548263 2491 3500 2189 3179 3396 1002 1030 846 2832 2353 941 2325 M14565 GO_HAIR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hair cell. 18/64 Gene Ontology BP GO:0035315 0.000380426193730275 0.000614585531485619 3905 2454.63636363636 2354 3.45901812124523e-05 480 1.80640397613483 -1.71548121555033 -1 6.87210312888266 3902 2856 1967 1703 2718 1893 2354 2938 480 1878 4312 2326 M11317 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. 69/144 Gene Ontology BP GO:0097191 1.2058568534181e-05 2.90393847013498e-05 4440 2762.63636363636 2355 1.09623951179294e-06 1445 1.52092775908229 -1.59501250944409 -1 8.17441313484624 4437 3061 2355 1851 1802 2659 4061 2215 1445 2221 4282 2327 M11808 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. 13/26 Gene Ontology BP GO:1902116 0.000954114744574615 0.00143829699969478 1415 2305.36363636364 2356 8.67753440543937e-05 1130 1.02816426737287 1.22812823048377 1 3.46168550713655 1415 2356 2819 3067 2914 1939 1130 1832 3210 3170 1507 2328 M15779 GO_LYMPH_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. 9/28 Gene Ontology BP GO:0001945 4.7666378320118e-06 1.35112939279797e-05 2360 2325.81818181818 2357 4.76664805641897e-07 1189 1.32152922197546 1.14258306019533 1 7.62292385908027 2357 2446 4456 2505 1574 2496 1189 1562 3307 1927 1765 2329 M12181 GO_ESTABLISHMENT_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization or cell growth patterns. 69/172 Gene Ontology BP GO:0030010 5.63943606868147e-07 3.11342469285233e-06 2360 2167.54545454545 2358 5.12676137662162e-08 711 1.59000706519544 1.74244071889108 1 10.3722592538083 2358 2776 1894 2104 711 2609 1388 2852 1756 2508 2887 2330 M12277 GO_ALDITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 10/26 Gene Ontology BP GO:0019400 8.01955625477826e-07 3.79559629877018e-06 3485 2506.27272727273 2358 7.29050834373707e-08 862 1.13830334604327 -0.821887393756197 -1 7.30958949924023 3484 1507 2358 2241 862 3131 3390 4041 1743 2816 1996 2331 M11255 GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 51/124 Gene Ontology BP GO:0051341 1.84365454936486e-06 6.69803448568157e-06 2465 2267.90909090909 2359 1.67605099490446e-07 744 2.03241169986531 2.31673662323071 1 12.4572038292388 2462 2388 744 1590 1186 3723 2873 4459 1383 1780 2359 2332 M10574 GO_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_PROCESS.html Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. 1040/2967 Gene Ontology BP GO:0002376 4.14380076050155e-07 2.62836979931813e-06 1945 2201.18181818182 2361 4.14380153320055e-08 433 1.56063791436388 1.72370458468024 1 10.3166520892544 1941 1454 3606 1779 610 4138 2725 2657 2361 433 2509 2333 M11582 GO_RESPONSE_TO_GRAVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GRAVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. 6/20 Gene Ontology BP GO:0009629 6.86905448034751e-05 0.000129516450353057 3970 2793.63636363636 2362 6.8692668171776e-06 164 3.10016055608363 -3.32038166613418 -1 14.2775008979403 3967 1916 3772 1950 2362 4419 3850 1809 164 2178 4343 2334 M16655 GO_RESPONSE_TO_IRON_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IRON_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. 21/50 Gene Ontology BP GO:0010039 2.79193531608426e-06 8.99580546327495e-06 3375 2635.27272727273 2362 2.53812623566199e-07 1347 1.89142229905158 -1.27821376131649 -1 11.3060353933529 3372 2347 1595 2362 1347 4494 3322 2217 1651 2739 3542 2335 M12239 GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. 8/18 Gene Ontology BP GO:0042982 0.000639605960923698 0.000995204583300513 910 2213.90909090909 2363 6.39790128634787e-05 318 0.77299921422594 -0.77299921422594 -1 2.74903490256513 910 2363 3873 3078 2842 524 318 985 4159 4322 979 2336 M12519 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. 10/27 Gene Ontology BP GO:0031112 0.0371808202464879 0.0464810308035657 2060 2466.63636363636 2364 0.0034385883279827 1119 1.70151151739119 1.70151151739119 1 2.68629078816318 2060 3348 2364 3114 3938 2315 2763 1652 1119 2818 1642 2337 M14285 GO_REGULATION_OF_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACROSOME_REACTION.html Any process that modulates the frequency, rate or extent of the acrosome reaction. 3/28 Gene Ontology BP GO:0060046 0.000155397068621602 0.000269826117361378 1665 2049.27272727273 2365 1.55407936403226e-05 47 3.32806253801357 3.32806253801357 1 14.0703809690665 1661 2997 4218 1210 3330 2365 2727 532 47 2594 861 2338 M16766 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. 87/198 Gene Ontology BP GO:0032387 3.38820681828754e-05 6.94238493261653e-05 1880 2467.36363636364 2368 3.08023545543898e-06 1083 1.14616608187466 -0.780058742947958 -1 5.64626585297028 1879 3200 2441 3371 2143 2253 1615 2368 3246 3542 1083 2339 M13054 GO_REGULATION_OF_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_LOCALIZATION.html Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. 734/1866 Gene Ontology BP GO:0060341 7.92462195647e-07 3.7698790721199e-06 2570 2339.27272727273 2370 7.92462478245491e-08 786 1.56247911977638 1.81567439468255 1 10.0388904541054 2568 1595 4000 1628 893 4472 2751 2370 2167 786 2502 2340 M12152 GO_INNER_CELL_MASS_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_CELL_MASS_CELL_PROLIFERATION.html The proliferation of cells in the inner cell mass. 6/11 Gene Ontology BP GO:0001833 0.000148302419603553 0.000258860200834321 945 2119.45454545455 2371 1.48312317656686e-05 121 0.653397255002472 -0.653397255002472 -1 2.77637814205395 942 2371 3857 3299 2554 408 121 940 3784 4313 725 2341 M14155 GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. 38/102 Gene Ontology BP GO:0035305 7.74889275858096e-05 0.000144490397903981 1675 2088.18181818182 2371 7.04469609581762e-06 754 1.2476723527169 -1.28803903290476 -1 5.67581143636934 1675 2889 2663 2858 2371 754 1539 907 2825 3729 760 2342 M14471 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 34/81 Gene Ontology BP GO:0090280 1.34503002487857e-06 5.44314265028097e-06 2790 2394.63636363636 2372 1.22275531563644e-07 942 1.55947536534392 1.63073859685119 1 9.72489284112635 2790 2140 1503 2372 1054 4004 3499 1657 2934 942 3446 2343 M12071 GO_HOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. 5/13 Gene Ontology BP GO:0050667 0.000122095922142422 0.000217533141407239 840 2055.18181818182 2374 1.22102630997598e-05 365 1.74993828783123 1.74993828783123 1 7.59233489820088 839 2374 3847 3025 3344 835 365 500 3037 2982 1459 2344 M13847 GO_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). 115/553 Gene Ontology BP GO:0002250 5.53651891778326e-06 1.52016897310867e-05 2390 2258.54545454545 2375 5.0332116827574e-07 1103 1.38684327898778 -1.22646303772564 -1 7.9155653448736 2387 2130 1103 2714 1590 1267 2424 4541 2900 1413 2375 2345 M16043 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 51/151 Gene Ontology BP GO:0032729 0.000108666281632947 0.000195633014975484 2445 2292.72727272727 2375 9.8792408582593e-06 1645 1.5785768949768 -1.75120319285725 -1 6.93503722353329 2443 2971 1645 2692 2453 1727 2375 1668 2908 2132 2206 2346 M14398 GO_CELLULAR_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, as carried out by individual cells. 437/1131 Gene Ontology BP GO:0044255 3.35093239321488e-07 2.39728491551567e-06 3610 2390.27272727273 2376 3.04630263964783e-08 471 1.42897897461865 -1.26947438607958 -1 9.51397143234497 3606 1525 1443 2484 471 1868 4128 3695 2376 1553 3144 2347 M16513 GO_POLYOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 14/43 Gene Ontology BP GO:0046173 7.86782050515622e-05 0.000146179634275471 2640 2509.81818181818 2376 7.15281990427018e-06 1805 1.49401615971646 -1.24546571690638 -1 6.78752540950541 2638 1805 1980 3290 2376 2229 2274 3426 2965 2631 1994 2348 M13437 GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. 12/44 Gene Ontology BP GO:0035116 7.88927075256011e-05 0.000146460952035732 3065 2374.27272727273 2377 7.17232152595523e-06 624 1.82273375832592 1.69669954206357 1 8.2791331059405 3064 2032 1633 1399 2377 4188 2933 3240 624 1113 3514 2349 M10131 GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 30/65 Gene Ontology BP GO:0050854 2.62183305162504e-05 5.60975615608066e-05 2700 2433.09090909091 2378 2.38351299785434e-06 1017 1.97569175419855 -2.10217531070712 -1 9.94933475173941 2697 2143 1017 2611 2040 3367 2378 3659 2099 1627 3126 2350 M11214 GO_RESPONSE_TO_POTASSIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_POTASSIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. 5/20 Gene Ontology BP GO:0035864 1.434549286473e-05 3.35040862026869e-05 4415 2619.72727272727 2378 1.43455854724959e-06 80 2.85521516729328 -2.38236779657299 -1 15.1356280188246 4413 1727 3710 388 1888 2378 4164 4626 80 1966 3477 2351 M13988 GO_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_PROCESS.html A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 35/119 Gene Ontology BP GO:0022600 2.33053714751127e-05 5.08490788340921e-05 3105 2306.81818181818 2378 2.1186925782497e-06 464 2.5736704799391 -2.77463196015147 -1 13.0907459475207 3104 2754 464 1273 2005 4342 3577 2378 1128 996 3354 2352 M11337 GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY.html The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. 4/34 Gene Ontology BP GO:0007214 9.18390230951529e-05 0.000168208514489466 990 2180.63636363636 2379 9.18428187987043e-06 87 1.06312672163324 1.06312672163324 1 4.75315932516015 988 2379 3732 2626 3198 630 87 2231 3921 2774 1421 2353 M12375 GO_SYNAPTIC_VESICLE_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_ENDOCYTOSIS.html Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. 12/27 Gene Ontology BP GO:0048488 0.0035880765577995 0.0050133732945721 2885 2665.18181818182 2379 0.000326721991471864 501 1.41608834748514 1.86479111970067 1 3.85808277842437 2885 3635 2379 2167 3155 3886 3845 2196 501 2347 2321 2354 M10141 GO_DENTATE_GYRUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENTATE_GYRUS_DEVELOPMENT.html The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. 6/19 Gene Ontology BP GO:0021542 7.74329536747588e-06 1.99808790367567e-05 4065 2348.36363636364 2380 7.74332234898862e-07 189 2.07167481211729 -1.44030906545353 -1 11.5329574124266 4061 1952 3542 923 2380 4392 3682 189 201 1293 3217 2355 M12815 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that stops or decreases the rate or extent of glial cell proliferation. 7/16 Gene Ontology BP GO:0060253 0.000316103159928544 0.000518610237296194 2955 2278.81818181818 2380 3.16148133475921e-05 613 1.08711449758551 -0.865652093465402 -1 4.23067436750604 2954 613 3964 1418 2699 2146 2513 1669 1559 2380 3152 2356 M10116 GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of hepatocyte proliferation. 6/16 Gene Ontology BP GO:2000345 0.000132542658483933 0.000234347129985111 3765 2268.81818181818 2383 1.32550564547948e-05 691 1.61617946859806 -0.976819823980655 -1 6.9500991367199 3765 722 3536 691 2518 2383 3211 1046 1266 1292 4527 2357 M11219 GO_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. 854/2124 Gene Ontology BP GO:0044281 1.43662412521433e-06 5.69133601823392e-06 2835 2290.27272727273 2384 1.43662505396517e-07 944 1.44443413442788 -1.26198463235645 -1 8.97436062236075 2835 1136 3711 3287 1111 944 2319 2624 2384 2637 2205 2358 M15271 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 6/17 Gene Ontology BP GO:0044252 0.0348672227090826 0.0437536527130461 1225 2590.09090909091 2385 0.00354266929294828 857 1.25631334939651 1.25631334939651 1 2.02250962492797 1224 2121 4378 2509 3831 1519 857 2340 4174 3153 2385 2359 M10354 GO_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_GASEOUS_EXCHANGE.html The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. 29/68 Gene Ontology BP GO:0007585 0.0543833568503348 0.0667994512846837 1170 2336.72727272727 2386 0.00507055853844686 1166 1.73227642417032 1.89911301066329 1 2.41166395766414 1621 3003 1170 2852 4359 2904 1984 2386 2531 1166 1728 2360 M14771 GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a steroid hormone binding to a receptor. 58/224 Gene Ontology BP GO:0043401 0.000278352153431637 0.000461449877645114 3290 2350.45454545455 2387 2.53079434379325e-05 946 1.74651590425862 -1.60915223723043 -1 6.90176820998574 3289 2387 1350 1433 2660 2084 3631 4339 946 1274 2462 2361 M10285 GO_AMMONIUM_ION_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_METABOLIC_PROCESS.html The chemical reactions and pathways involving the ammonium ion. 66/208 Gene Ontology BP GO:0097164 1.03106493348478e-06 4.49083910522499e-06 3645 2495.18181818182 2388 9.37332197009136e-08 957 1.54373395935778 -1.48374921502732 -1 9.77946930275277 3643 2253 1511 2388 957 2406 3965 2212 2490 2339 3283 2362 M14087 GO_RESPONSE_TO_VITAMIN_A http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_A.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. 7/32 Gene Ontology BP GO:0033189 0.000399819849190252 0.000644123372585128 1845 2515.36363636364 2390 3.99891802571213e-05 1607 2.89506116929841 -2.89506116929841 -1 10.9437659041658 1843 3386 4182 3293 2746 1682 2144 1607 2390 2393 2003 2363 M15087 GO_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 112/329 Gene Ontology BP GO:0016042 1.24965784298689e-06 5.17126681371492e-06 2090 2502.54545454545 2390 1.13605322984179e-07 1031 1.53434253273047 -1.5325635478202 -1 9.60861122972125 2087 2970 1953 4198 1031 1888 2804 2261 2856 3090 2390 2364 M15000 GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 16/34 Gene Ontology BP GO:0050858 2.62747783724283e-05 5.61850264450018e-05 2045 2802.18181818182 2391 2.38864474358942e-06 1202 2.12210698419999 -2.14538677678411 -1 10.6849626184187 4110 1496 1202 2391 2041 4416 3831 3264 2041 1620 4412 2365 M16039 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 12/31 Gene Ontology BP GO:1902176 0.000219262190883962 0.000371816783153483 2290 2307.54545454545 2393 1.99349133290162e-05 1302 1.19021341475924 -0.93503098091938 -1 4.83565439347214 2286 1573 2763 1302 2608 2476 2182 1943 2393 3061 2796 2366 M14096 GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 42/106 Gene Ontology BP GO:0008286 0.000132500303720622 0.000234347129985111 2310 2504.18181818182 2395 1.20462076857983e-05 1201 1.23038989569399 -1.14378537960063 -1 5.29107767376471 2308 2395 2387 3020 2496 1201 3089 2125 2817 3635 2073 2367 M15102 GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 6/15 Gene Ontology BP GO:0009143 1.85642988507991e-05 4.18824293315162e-05 4320 2621.90909090909 2395 1.85644539375589e-06 616 1.22802515286078 -0.764726848497022 -1 6.36880344099286 4317 616 4353 2395 1974 2744 1836 2653 1343 2197 4413 2368 M13947 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. 18/38 Gene Ontology BP GO:0070229 8.69252623759012e-05 0.000159965910904205 4165 2627.72727272727 2396 7.90260882835606e-06 1345 1.76541817822554 -1.65209564178127 -1 7.93868678992645 4164 1932 1686 1586 2396 3280 3756 4006 1532 1345 3222 2369 M14436 GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. 16/59 Gene Ontology BP GO:0046597 4.45773987205626e-05 8.86272345272819e-05 2935 2434.72727272727 2397 4.05257290851597e-06 1314 1.5793633763413 1.24457170851517 1 7.58186226093913 2932 2595 2030 2698 2212 2397 2234 1314 3398 2855 2117 2370 M15481 GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 44/104 Gene Ontology BP GO:0046916 3.90344031420322e-08 6.29294214543249e-07 3785 2800.72727272727 2398 3.54858216678329e-09 30 1.5639607086409 1.72080816539449 1 11.4888312625821 3781 1617 2385 2398 30 3841 4032 4383 2314 2013 4014 2371 M11762 GO_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_PROCESS.html Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. 289/703 Gene Ontology BP GO:0007017 7.44650674702204e-06 1.93801181762463e-05 1540 2660.27272727273 2400 6.76957450172479e-07 1483 1.36391140364673 1.55752273824205 1 7.61427856493525 1536 4076 2939 4111 1671 2400 1483 1995 2881 4056 2115 2372 M13898 GO_NEGATIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEATH.html Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 527/1365 Gene Ontology BP GO:0060548 3.23881230879772e-07 2.34233731304483e-06 2405 2147.45454545455 2401 3.23881278084355e-08 301 1.72079287636978 1.91203057245028 1 11.4773618446096 2401 1304 4152 661 487 4150 2879 2766 1744 301 2777 2373 M14824 GO_HEART_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_FORMATION.html The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. 7/21 Gene Ontology BP GO:0060347 1.09988872699785e-07 1.29465148368895e-06 2425 2067 2401 1.09988878143684e-08 152 1.40304421005404 1.7673947237727 1 9.78601570256457 2422 338 4298 1358 152 3222 2401 773 2613 3293 1867 2374 M15613 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. 7/21 Gene Ontology BP GO:0060742 0.000251599458810384 0.000420485982414314 2510 2414.54545454545 2401 2.51627949379809e-05 54 3.42545921417738 -1.29214926568553 -1 13.7003370176448 2508 3699 4431 2385 3693 2909 1848 601 54 2401 2031 2375 M11232 GO_REGULATION_OF_RUFFLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RUFFLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of ruffle assembly. 16/35 Gene Ontology BP GO:1900027 7.04577272199292e-06 1.85135952168722e-05 3195 2389.90909090909 2402 6.40526844277697e-07 1005 1.1187954662528 1.11659142313173 1 6.27220368397741 3191 1005 2402 2042 1661 3255 2200 2519 2597 1613 3804 2376 M16456 GO_EMBRYONIC_PLACENTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_MORPHOGENESIS.html The process in which the embryonic placenta is generated and organized. 13/31 Gene Ontology BP GO:0060669 1.81912483935632e-05 4.12009591664946e-05 3615 2785.90909090909 2402 1.65376352856149e-06 1748 1.70951751292219 -2.53691885505235 -1 8.88035545554927 3615 2279 1963 2402 1935 3581 3144 1748 2300 3185 4493 2377 M11935 GO_REGULATION_OF_GLOMERULAR_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULAR_FILTRATION.html Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. 8/13 Gene Ontology BP GO:0003093 0.000364492169758909 0.000590281529191007 2255 2490.45454545455 2403 3.6455196810734e-05 1397 1.56536294077562 1.8369349544004 1 5.98760456845659 2251 2965 3829 2403 2731 3059 2148 1397 2588 1736 2288 2378 M15824 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. 14/35 Gene Ontology BP GO:2000352 1.5481258206571e-05 3.58501156374608e-05 3705 2633 2404 1.40739701347822e-06 1198 1.0928433878663 -0.973007489511075 -1 5.75516050913167 3701 1198 2150 2320 1881 2537 4408 2375 3363 2626 2404 2379 M14544 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. 96/288 Gene Ontology BP GO:0002703 1.81057206276941e-05 4.10472953488202e-05 2405 2492 2405 1.64598814883569e-06 1603 1.5347197246542 -1.44573340738181 -1 7.97529120388723 2876 3333 1603 3010 1933 1867 3275 2401 3036 1673 2405 2380 M15952 GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT.html The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. 6/23 Gene Ontology BP GO:0060841 6.74163677954206e-05 0.000127396905036279 3110 2313.72727272727 2405 6.74184131177412e-06 485 1.51976099947803 1.48276267479626 1 7.01201827937402 3107 1519 4486 965 2359 2803 2405 3262 485 760 3300 2381 M13877 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS.html The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. 36/110 Gene Ontology BP GO:0017156 8.60189552004264e-06 2.18602084836114e-05 2945 2622.45454545455 2406 7.8199355938452e-07 1546 1.29935344725527 -1.28221947753242 -1 7.17337337146069 2944 1546 2092 1919 1711 2986 2406 4492 2773 1775 4203 2382 M10630 GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. 10/23 Gene Ontology BP GO:0045618 0.000329174735200848 0.000537208539732 2025 2205.63636363636 2408 2.99294543864237e-05 744 1.17688457883796 -0.983246224151129 -1 4.55869551816957 2023 2408 2735 3264 2693 1022 1206 744 3441 2806 1920 2383 M14618 GO_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 7/33 Gene Ontology BP GO:0072215 0.000838278083828675 0.00127485265090617 3275 2468.54545454545 2408 8.38594471380353e-05 1080 2.52710871020241 -2.84900492556635 -1 8.66525801725379 3271 2177 4260 1756 2911 2645 3777 1364 1080 1505 2408 2384 M13033 GO_RESPONSE_TO_PROTOZOAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROTOZOAN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. 11/25 Gene Ontology BP GO:0001562 2.81841406416825e-05 5.95083969983319e-05 4630 2800.27272727273 2411 2.56222742858398e-06 1020 1.61744990511344 1.77421957575922 1 8.09615685394898 4627 1020 2084 2404 2074 3790 3736 2411 2627 1538 4492 2385 M12052 GO_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. 43/117 Gene Ontology BP GO:0030183 2.43270314367516e-06 8.17888537008239e-06 4535 2536.36363636364 2412 2.21155075790872e-07 1100 1.84480694581264 -1.15887176875002 -1 11.1177476393409 4533 2779 1465 1971 1291 2412 4285 2069 1100 2656 3339 2386 M12261 GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. 16/46 Gene Ontology BP GO:0030513 4.72673361042685e-05 9.34279444581177e-05 2985 2431 2412 4.29712288006853e-06 1809 1.54490818118094 1.62916115301275 1 7.37452983319934 1809 2984 2412 1858 2227 2765 2494 3064 2985 2254 1889 2387 M13399 GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. 10/30 Gene Ontology BP GO:0033630 0.0020563366687881 0.00295316150732544 2380 2491.09090909091 2412 0.000187114658407692 1301 1.63718744180073 -1.63718744180073 -1 4.90622629651201 2377 2642 1995 2412 3061 2672 3002 1301 3716 2069 2155 2388 M16480 GO_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 160/439 Gene Ontology BP GO:0009615 9.01111381893699e-08 1.15896402939957e-06 4085 2488.90909090909 2412 8.19192198911703e-09 100 1.44231677090128 -1.20612319353224 -1 10.1420899282651 4084 1603 1421 3441 100 2143 3290 4569 2412 1482 2833 2389 M10608 GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-10 production. 23/70 Gene Ontology BP GO:0032653 3.43124547018069e-05 7.02127488675581e-05 3300 2530.27272727273 2414 3.11936271546409e-06 973 2.15805907876965 -2.15830053002639 -1 10.6185291329191 3296 3367 973 2673 2145 3885 2414 4105 1863 1031 2081 2390 M11143 GO_POSITIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COAGULATION.html Any process that activates or increases the frequency, rate or extent of coagulation. 11/46 Gene Ontology BP GO:0050820 0.108879900885303 0.122404208186552 915 2515.90909090909 2414 0.010424922517275 914 1.23849483455717 1.23849483455717 1 1.33833107396628 914 3719 1957 3134 3825 1394 1254 2414 4173 2919 1972 2391 M12832 GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. 21/61 Gene Ontology BP GO:0034123 1.52122155687202e-05 3.52798785642197e-05 2910 2404.63636363636 2415 1.38293825061682e-06 884 1.30168360700512 -1.6117501561314 -1 6.86569833374426 2909 2756 2225 2454 1879 2415 3782 884 2325 2734 2088 2392 M10123 GO_SINGLE_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_FERTILIZATION.html The union of male and female gametes to form a zygote. 40/166 Gene Ontology BP GO:0007338 9.36775109374946e-05 0.000171238064284562 2020 2397.45454545455 2417 8.51650000255006e-06 821 1.41168842049252 -1.42821925992364 -1 6.29858861056361 2019 4230 2584 4455 2417 821 1127 1139 3443 3223 914 2393 M11819 GO_REGULATION_OF_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_BINDING.html Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 10/33 Gene Ontology BP GO:0035561 0.000155398457425011 0.000269826117361378 1445 2237.81818181818 2419 1.41281304712366e-05 520 1.6238867796609 1.6238867796609 1 6.86546677338768 1442 3558 2624 2969 3301 1844 1535 520 2419 2814 1590 2394 M11045 GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. 11/21 Gene Ontology BP GO:0003323 0.000120692112873995 0.000215114579682901 4580 2546.18181818182 2420 1.09726122325525e-05 184 1.58071861748426 -1.0530562876706 -1 6.86724549369962 4577 1434 1998 1663 2475 3674 3398 2420 184 2228 3957 2395 M12354 GO_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS.html Any process that modulates the frequency, rate or extent of hemopoiesis. 187/511 Gene Ontology BP GO:1903706 1.78215893079137e-06 6.54417064190877e-06 3080 2131.36363636364 2420 1.62014579497317e-07 670 1.5860110556178 -1.57956554665882 -1 9.74005500435625 3076 2420 840 2328 1171 1841 2839 2831 2455 670 2974 2396 M13775 GO_VOCALIZATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOCALIZATION_BEHAVIOR.html The behavior in which an organism produces sounds by a mechanism involving its respiratory system. 7/36 Gene Ontology BP GO:0071625 5.17579936496999e-05 0.000101226775280352 4195 2560.90909090909 2420 5.17591991896758e-06 376 1.91890980628655 -0.735045434022753 -1 9.08065661078426 4191 1586 4132 1545 2420 3805 3288 388 376 2390 4049 2397 M13922 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). 121/264 Gene Ontology BP GO:0097193 2.40968658753023e-07 1.98730728824007e-06 2255 2255.09090909091 2421 2.19062441042378e-08 366 1.51310953800409 1.72831379087354 1 10.2201066039788 2254 3273 2421 3012 366 2641 1860 1531 2539 3607 1302 2398 M14161 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 95/262 Gene Ontology BP GO:0071241 2.07825224584056e-08 3.86889012325632e-07 3825 2598.09090909091 2421 1.88932024133908e-09 6 1.8660450579317 1.97002980589391 1 14.1749554636505 3823 2249 489 1620 6 3174 4274 4363 2421 1625 4535 2399 M16113 GO_MIDGUT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDGUT_DEVELOPMENT.html The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. 9/25 Gene Ontology BP GO:0007494 7.88596926012898e-05 0.000146458221099115 2690 2552.90909090909 2421 7.88624912240691e-06 1026 1.98927569688012 -1.98927569688012 -1 9.0356110799648 2690 1026 4511 1767 2395 2751 4236 1612 2740 1933 2421 2400 M16166 GO_EPOXYGENASE_P450_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPOXYGENASE_P450_PATHWAY.html The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. 2/57 Gene Ontology BP GO:0019373 0.0844055892703865 0.0955142946581537 1975 2954.2 2422.5 0.00975013347365843 1653 0.663950119687647 -0.663950119687647 -1 0.802201932354807 1974 2572 4520 NA 3624 1653 2051 2039 4242 4594 2273 2401 M12544 GO_IN_UTERO_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IN_UTERO_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. 168/428 Gene Ontology BP GO:0001701 2.84720660491993e-07 2.17485745049544e-06 2425 2301.63636363636 2424 2.58836997581923e-08 416 1.62458343012824 1.6657150663795 1 10.8976680942031 2424 2574 1309 2097 416 3679 1871 3026 2232 2612 3078 2402 M13520 GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of lymphocyte differentiation. 68/229 Gene Ontology BP GO:0045619 0.000750732963350653 0.00115380772884379 2240 2704.36363636364 2424 6.82717516014287e-05 1542 1.455371915421 -1.43929413171452 -1 5.06505321847962 2238 3903 1898 3942 2864 1542 1954 3572 3253 2158 2424 2403 M16373 GO_TRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_PROCESSING.html The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. 67/118 Gene Ontology BP GO:0008033 9.57061204259959e-05 0.000174192643794418 1055 2801.09090909091 2426 8.70093492382544e-06 1055 0.905494444608962 -0.948572609980234 -1 4.0321120485548 1055 3823 3426 4520 2426 1800 2358 1834 3376 4141 2053 2404 M13776 GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT.html The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. 19/41 Gene Ontology BP GO:0043001 3.39983480938704e-06 1.04524078671069e-05 3220 2277.54545454545 2427 3.09076369403026e-07 143 1.33604669331113 -1.52739839774442 -1 7.88310522063953 3218 143 2519 1487 1416 2206 3784 3401 1371 3081 2427 2405 M10482 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. 9/23 Gene Ontology BP GO:0045603 4.14648828856718e-06 1.21404827899932e-05 2370 2351.45454545455 2428 4.1464960256018e-07 714 1.80557162195672 -1.77799562889587 -1 10.5143827174937 2367 714 3596 2428 1526 2265 3443 3041 2984 768 2734 2406 M11809 GO_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 19/55 Gene Ontology BP GO:0035456 3.90324036178791e-07 2.57804519639595e-06 3230 2256.27272727273 2431 3.5484009584555e-08 538 1.23258906226806 1.1342591896597 1 8.1603325091258 3226 1187 2431 1172 538 3522 2691 3256 2171 1448 3177 2407 M11040 GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. 12/31 Gene Ontology BP GO:0045606 0.000620997952783921 0.000970264198701068 2145 2575.81818181818 2433 5.64703011176717e-05 1522 1.17688457883796 -0.983246224151129 -1 4.20074951364544 2141 2406 2710 3641 2809 1522 1545 2288 3799 3040 2433 2408 M11270 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. 23/62 Gene Ontology BP GO:0086004 0.000498943840807496 0.000792811859298154 1915 2397.36363636364 2433 4.53688212315664e-05 1047 1.46551045960804 1.19351076746337 1 5.38325343523537 1912 2433 1952 2513 2767 1564 1047 3422 3154 2421 3186 2409 M10671 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. 32/82 Gene Ontology BP GO:0051148 8.50469829816758e-06 2.16606221603906e-05 3730 2553.36363636364 2436 7.73157379597242e-07 939 1.9173232475045 1.76724922561228 1 10.5940630573886 3150 2262 939 2436 1707 4285 3730 3086 1693 1073 3726 2410 M12335 GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 16/35 Gene Ontology BP GO:0009225 0.000459644710686293 0.000733378141483319 1980 2449.81818181818 2436 4.17946156441426e-05 1288 0.883616685126022 -0.92047913912373 -1 3.2812090218667 1978 2436 3203 3157 2757 1849 2312 1288 3217 3423 1328 2411 M11123 GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS.html A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism. 697/1598 Gene Ontology BP GO:0044711 6.10377970105544e-07 3.23212152206309e-06 2585 2280.27272727273 2437 6.10378137758179e-08 789 1.43071410642953 -1.21912780078462 -1 9.30558654724696 2584 951 3695 3096 789 1245 2757 2437 2244 2868 2417 2412 M11054 GO_BARBED_END_ACTIN_FILAMENT_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BARBED_END_ACTIN_FILAMENT_CAPPING.html The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. 9/19 Gene Ontology BP GO:0051016 8.62747561363705e-06 2.18773180088022e-05 3260 2330.27272727273 2438 8.62750910882102e-07 296 1.51397458261714 -1.93044514769367 -1 8.35762857899076 3258 1119 3677 1041 1745 4163 4073 1152 296 2671 2438 2413 M10717 GO_NEGATIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. 18/49 Gene Ontology BP GO:0014014 2.49270146944438e-05 5.3743237611465e-05 4030 2796.90909090909 2439 2.26611792122704e-06 714 1.66595028221774 -0.896210618974632 -1 8.42626259673691 4030 1700 2236 1861 2022 3768 3919 4378 714 2439 3699 2414 M11273 GO_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_PROCESS.html A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. 11/21 Gene Ontology BP GO:0003016 0.00464566541732947 0.00642341409549158 2440 2412.27272727273 2439 0.000423227691976648 1529 1.6446605137032 2.0798336128586 1 4.27111358555791 2439 2814 1685 2802 3191 4141 2925 1615 1764 1529 1630 2415 M11372 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. 430/1043 Gene Ontology BP GO:0019637 3.10044575837732e-07 2.28497931049935e-06 1915 2369.09090909091 2440 2.81858745029202e-08 446 1.35981105051792 -1.15719633506953 -1 9.08702558462478 1914 3676 2961 4199 446 775 1780 2440 2691 3795 1383 2416 M10315 GO_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACTIVATION_CASCADE.html A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. 25/269 Gene Ontology BP GO:0072376 0.0001026078307642 0.000185589465616744 2220 2582.90909090909 2441 9.32841969982171e-06 988 1.55966629293215 1.5112569252052 1 6.89424832367508 2220 2098 988 2740 2441 3532 3295 2308 3407 2126 3257 2417 M11737 GO_SINGLE_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves only one organism. 56/124 Gene Ontology BP GO:1902591 1.50048429712818e-05 3.48337429578307e-05 4380 2733.36363636364 2441 1.36408593736704e-06 1020 1.78035170477986 2.0479846751357 1 9.40207863170645 4376 2056 1962 2648 1875 3220 4302 2441 1020 2102 4065 2418 M15426 GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 914/2257 Gene Ontology BP GO:0031399 1.09380650486525e-07 1.29465148368895e-06 1830 2252.09090909091 2441 1.09380655870382e-08 149 1.52145042904817 1.64828325026607 1 10.6118808529158 1830 2881 4403 2537 149 3487 2545 1974 2441 730 1796 2419 M13362 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 18/39 Gene Ontology BP GO:0098901 0.0314656120844171 0.0397536971178091 1370 2434 2442 0.00290226121882353 805 1.5903778388447 1.19351076746337 1 2.63875598522449 1369 2917 1797 3036 3491 1017 805 4209 3262 2442 2429 2420 M13839 GO_SIGNAL_RELEASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_RELEASE.html The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. 81/246 Gene Ontology BP GO:0023061 7.98124386029355e-05 0.000147931797378615 2385 2506.81818181818 2442 7.25593947418861e-06 1526 1.47754846241824 1.6957303094368 1 6.70365296170616 2442 2885 1526 2382 2381 2528 2083 3076 3028 2017 3227 2421 M16383 GO_RECEPTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 12/24 Gene Ontology BP GO:0032801 0.00608180193071236 0.00827845393265831 1990 2539.81818181818 2442 0.000554425469093808 1034 1.10574402504055 -1.36052779890187 -1 2.72724245689331 1986 3527 2704 3531 3451 1034 2442 1979 3847 2366 1071 2422 M16776 GO_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ASSEMBLY.html Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 14/40 Gene Ontology BP GO:0030032 2.72345825045144e-05 5.77661793368937e-05 585 1860.09090909091 2444 2.47590178699467e-06 292 1.30974773260454 -1.30974773260454 -1 6.57597329241468 584 2926 2683 3030 3667 341 607 292 2444 3251 636 2423 M12766 GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION.html The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 82/271 Gene Ontology BP GO:0009952 1.50823471080509e-06 5.88959946364007e-06 1445 2351.27272727273 2445 1.37112340435757e-07 1093 1.63932391985091 1.69751079174571 1 10.1563433152776 1441 3304 1282 3471 1093 2445 1731 2792 3366 2613 2326 2424 M13490 GO_INOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. 5/13 Gene Ontology BP GO:0006020 5.20337452522221e-05 0.000101680420541274 2445 2793.54545454545 2445 5.20349636721653e-06 1384 0.889524371656763 -0.889524371656763 -1 4.20735614445958 2445 3023 4085 3729 2283 1466 1384 1457 4330 4415 2112 2425 M16085 GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. 8/36 Gene Ontology BP GO:0048486 0.0264205621055888 0.0335991974407693 1705 2789.09090909091 2445 0.00267400418435075 1705 1.69033374273268 -0.844053965741403 -1 2.9508754600043 1705 2284 4505 2085 3434 2318 2115 2510 3873 3406 2445 2426 M12755 GO_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE.html An immune response mediated through a body fluid. 76/484 Gene Ontology BP GO:0006959 8.80477251181981e-05 0.000161775064394062 2815 2358 2446 8.00465901224513e-06 681 1.72356874913219 -1.62317214005759 -1 7.74052703604095 2813 1468 681 2579 2401 1875 2703 4228 2979 1765 2446 2427 M13467 GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 8/35 Gene Ontology BP GO:0043949 0.000948832671646806 0.00143079899137906 2105 2700.45454545455 2447 9.49238042814081e-05 1121 0.978401543662129 0.978401543662129 1 3.29677222682845 2104 2447 4081 3626 2933 2025 1121 2158 4059 3393 1758 2428 M15020 GO_ASYMMETRIC_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. 18/51 Gene Ontology BP GO:0008105 2.54298076519316e-06 8.44913067604104e-06 3535 2544 2448 2.3118033678457e-07 716 1.7402771185775 -1.33496757700192 -1 10.4586925422423 3531 2468 2153 1787 1308 3817 2303 3964 716 2448 3489 2429 M11245 GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 22/69 Gene Ontology BP GO:0051349 7.40347931700721e-07 3.61454831428648e-06 2475 2083 2449 6.73043800767315e-08 445 1.22960305905074 1.50449678387692 1 7.92678665827435 2471 445 1471 1168 832 2449 2634 2860 3692 2302 2589 2430 M16065 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. 18/26 Gene Ontology BP GO:0016601 3.66845738438443e-07 2.53906434788708e-06 2565 2126.09090909091 2450 3.33496181462976e-08 146 1.01497364439374 1.11813522559733 1 6.72756923423926 2565 146 2658 1361 500 3647 2820 1672 2445 2450 3123 2431 M11484 GO_MEMBRANE_RAFT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_RAFT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. 8/25 Gene Ontology BP GO:0031579 3.38833693968462e-06 1.0425479397585e-05 2335 2516.90909090909 2451 3.38834210606796e-07 1453 0.906232412843913 -0.751976009954791 -1 5.34826487823814 2334 1662 3756 2451 1453 1772 1457 4061 2720 3371 2649 2432 M11643 GO_PEPTIDYL_CYSTEINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_CYSTEINE_MODIFICATION.html The modification of peptidyl-cysteine. 11/37 Gene Ontology BP GO:0018198 0.0100293415563935 0.0132894500132234 2165 2917.18181818182 2451 0.000915941562704823 1197 1.04550730232093 -1.04550730232093 -1 2.32408391383451 2161 3809 2451 4007 4491 1767 2231 2042 4287 3646 1197 2433 M13911 GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 148/357 Gene Ontology BP GO:0051091 1.52381870400794e-06 5.92553621667409e-06 1980 2179.45454545455 2451 1.38529069043106e-07 874 1.45538403964866 1.4070056894016 1 9.01219865347206 1979 2884 1874 2117 1097 2665 2456 2872 2705 874 2451 2434 M11498 GO_DRUG_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSMEMBRANE_TRANSPORT.html The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 11/45 Gene Ontology BP GO:0006855 0.000108493727271611 0.000195398128674202 1600 2687.63636363636 2452 9.86355254955149e-06 1446 1.90521889674468 1.91357870417951 1 8.37122564698335 3556 2109 1446 2845 2452 3653 1596 4606 1598 1531 4172 2435 M14656 GO_ENDOCYTIC_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_RECYCLING.html The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. 13/29 Gene Ontology BP GO:0032456 0.000246965023395026 0.000413956174593178 2530 2202.81818181818 2452 2.24538864784707e-05 1120 1.44045329346843 -1.22459245552578 -1 5.7727800706467 2526 2795 2324 2808 2633 1120 2452 2875 1398 1256 2044 2436 M15458 GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 8/32 Gene Ontology BP GO:0045408 0.00041263329054957 0.000662696772058684 1255 2429.54545454545 2452 4.12709930383566e-05 675 1.00068113499536 -1.00068113499536 -1 3.76808883156746 1251 4017 4409 2452 3082 1122 2280 675 3439 2538 1460 2437 M10918 GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL.html Any virus-mediated process that modulates the levels of viral proteins in a cell. 5/18 Gene Ontology BP GO:0046719 3.03815943311868e-05 6.33131698741923e-05 1360 2455.27272727273 2453 3.03820097077527e-06 1262 0.973876752179509 -0.973876752179509 -1 4.84369425635227 1360 2332 3659 3023 2137 1262 2453 3287 3088 2970 1437 2438 M11168 GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. 17/51 Gene Ontology BP GO:0034122 0.000311800877727208 0.000512366873595874 1925 2216.63636363636 2453 2.83495524827195e-05 921 1.25706531925771 -0.995475861711486 -1 4.8998975104071 1923 2665 2535 2101 2679 921 1553 2633 2453 2904 2016 2439 M13329 GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. 33/119 Gene Ontology BP GO:0002762 3.20124596769299e-06 9.95461981468168e-06 2455 2583.18181818182 2453 2.91022784170297e-07 1398 1.44229676924751 -1.87086842996747 -1 8.54622242488547 2453 3963 2371 3546 1398 1636 3013 1603 3291 3196 1945 2440 M11050 GO_LYMPHOCYTE_COSTIMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_COSTIMULATION.html The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. 37/114 Gene Ontology BP GO:0031294 2.33842975921228e-05 5.09733773334395e-05 2555 2609.36363636364 2454 2.12586783207361e-06 1864 1.35534197944632 1.33036409917233 1 6.89212320507754 2551 2093 1955 2724 2006 3951 2454 2363 3422 1864 3320 2441 M13846 GO_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T cell differentiation. 51/190 Gene Ontology BP GO:0045580 0.00126126076263692 0.0018679533400074 2085 2768.90909090909 2454 0.00011472585679655 1770 1.35181501619832 -1.32244798789764 -1 4.36958793274626 2082 3707 2143 3658 2958 1770 2259 3715 3401 2454 2311 2442 M14572 GO_PERICARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. 13/30 Gene Ontology BP GO:0060039 0.000158691584793169 0.000274927249326375 3990 2454 2454 1.4427548434193e-05 464 1.59000511830145 -1.18543229309168 -1 6.70690148146288 3987 1351 1752 776 2548 2454 3405 3974 464 1849 4434 2443 M15348 GO_REGULATION_OF_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPIRATION.html Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. 19/34 Gene Ontology BP GO:0043457 0.000322258543592241 0.000527962744494981 1630 2355.27272727273 2455 2.93005234617295e-05 620 1.3315166800767 1.70759608118461 1 5.16956007609485 1626 3253 2154 2688 3421 2455 1309 620 3682 3082 1618 2444 M11805 GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE.html An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. 22/108 Gene Ontology BP GO:0002251 0.0142297001251982 0.0185585667644088 1025 2319.18181818182 2456 0.00130205278426341 1023 1.74995463402877 -1.77377225382513 -1 3.58935190492412 1023 2501 1827 2621 3338 1339 2104 2456 3412 2862 2028 2445 M12902 GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 9/15 Gene Ontology BP GO:1902895 4.26382603635791e-05 8.5111540356018e-05 955 1991.63636363636 2457 4.26390784952334e-06 256 1.26186391073124 1.26186391073124 1 6.0839570989928 953 3409 3977 2785 2598 491 628 861 2457 3493 256 2446 M13960 GO_ANDROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 16/68 Gene Ontology BP GO:0008209 6.72280548122447e-07 3.41883744242335e-06 3130 2395.36363636364 2457 6.1116432141765e-08 791 1.86674238513478 -2.50239771021035 -1 12.0876454896277 3126 2809 2177 2440 791 2801 3193 1368 2333 2854 2457 2447 M11235 GO_CELLULAR_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENTATION.html The deposition or aggregation of coloring matter in a cell. 29/56 Gene Ontology BP GO:0033059 5.04205654682551e-06 1.41110720596208e-05 2910 2495.09090909091 2458 4.58369827497186e-07 1286 1.27839425247677 -0.981107018883034 -1 7.34554371268787 2908 1550 2705 2002 1564 2013 4101 3902 1286 2458 2957 2448 M12904 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune system process. 447/1372 Gene Ontology BP GO:0002684 1.04533983878112e-06 4.5359933378138e-06 3335 2513.90909090909 2458 9.50309395890323e-08 311 1.66920795008586 -1.46510778744127 -1 10.5657487239502 3333 2247 311 1798 1143 3793 4453 3179 2458 481 4457 2449 M10503 GO_MYELOID_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MIGRATION.html The movement of a myeloid leukocyte within or between different tissues and organs of the body. 47/150 Gene Ontology BP GO:0097529 2.24405863217491e-05 4.91470010810761e-05 2460 2850.63636363636 2459 2.04007411136174e-06 703 1.88607950004657 -1.82759010896562 -1 9.62641139785162 4179 2459 703 2007 1999 3693 4213 4167 2459 1170 4308 2450 M12897 GO_RESPONSE_TO_GROWTH_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 15/67 Gene Ontology BP GO:0060416 0.00320439609220735 0.00449266342122976 2070 2459.72727272727 2459 0.000291733906798025 1535 1.69066951279654 -1.92371706255266 -1 4.70155531477928 2066 3664 2459 2787 3139 1798 3450 1535 1625 2720 1814 2451 M12060 GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. 36/125 Gene Ontology BP GO:1901616 3.41988546894449e-06 1.05016721113157e-05 4040 2659 2461 3.10899162285948e-07 932 1.70809890781308 -1.67255740392818 -1 10.0742013355746 4037 2461 932 2030 1418 2992 4291 3568 2306 1360 3854 2452 M13822 GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. 29/84 Gene Ontology BP GO:1904888 1.17524135394651e-06 4.9407468605345e-06 3775 2646.81818181818 2461 1.06840180160148e-07 1005 1.61676683792083 -1.86871482283206 -1 10.1627125794872 3773 1626 1886 1763 1005 4628 3640 2579 1391 2461 4363 2453 M15281 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT.html Any process that modulates the frequency, rate or extent of actin filament-based movement. 25/71 Gene Ontology BP GO:1903115 5.23644213580685e-05 0.000102240541785329 2465 2548.36363636364 2461 4.76051525255168e-06 1056 1.40221141573212 -1.61091206400087 -1 6.62834954908303 2461 2430 1911 2951 2257 1931 1056 3447 3265 2605 3718 2454 M15786 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 10/22 Gene Ontology BP GO:1902043 0.000100911121692624 0.000183019663288615 2380 2649.36363636364 2462 9.17415915009171e-06 1319 0.802323584284725 -0.73412126757432 -1 3.55229412089992 2376 2797 2930 3578 2436 1319 2462 2071 3858 3596 1720 2455 M16000 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 292/975 Gene Ontology BP GO:0050778 1.99677852411444e-06 7.14082628632173e-06 3075 2363.36363636364 2462 1.81525485131459e-07 1208 1.59212165649747 -1.40406538221322 -1 9.70611171154495 3071 3027 1291 2480 1208 1346 2938 4045 2462 1953 2176 2456 M10629 GO_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 31/53 Gene Ontology BP GO:0070670 2.69067482583529e-05 5.72801614688366e-05 3835 2624.90909090909 2463 2.44609794024275e-06 1237 1.6084441902824 -1.47470991282979 -1 8.08265865988526 3832 2463 1237 2248 2052 2920 3231 3483 2406 2162 2840 2457 M11470 GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 15/27 Gene Ontology BP GO:0009067 0.000325891627305027 0.000532974577519281 2610 2365.72727272727 2463 2.96309011344829e-05 1424 1.34864227696185 -0.865372387214429 -1 5.22949413919399 2609 1424 2405 2463 2691 2790 1951 2835 1655 2114 3086 2458 M14692 GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT.html The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. 9/24 Gene Ontology BP GO:0060749 7.0104775235339e-05 0.000131940199196465 3895 2476.81818181818 2463 7.01069869393183e-06 773 2.21070787979467 -2.63574389466613 -1 10.160121446138 3893 2035 4274 1056 2366 3947 3114 2463 835 773 2489 2459 M14494 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. 19/67 Gene Ontology BP GO:0002833 3.16689849214395e-05 6.55254442915524e-05 815 1810 2465 2.87904007322253e-06 302 1.18902149925727 -1.2085881843766 -1 5.89273354754134 813 3661 2465 2766 2981 302 519 311 3091 2562 439 2460 M12716 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 20/81 Gene Ontology BP GO:0070098 0.000133368528720977 0.000235627883885652 1655 2288.54545454545 2466 1.21251467710893e-05 628 1.81719470064537 2.07629926680637 1 7.80943495378279 1652 2466 628 2275 2500 2926 3124 2352 3454 830 2967 2461 M15001 GO_CONVERGENT_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONVERGENT_EXTENSION.html The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. 10/25 Gene Ontology BP GO:0060026 6.95085065459806e-05 0.000130977271060466 2710 2475.36363636364 2466 6.31915479534535e-06 1268 1.26665263058551 1.13217007285679 1 5.82614086782619 2706 1357 2437 1268 2337 2612 2466 4428 2955 2083 2580 2462 M11889 GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. 257/638 Gene Ontology BP GO:0060627 5.18347400688352e-07 2.94576129913833e-06 4505 2322.90909090909 2467 4.71225020743177e-08 508 1.48726544453832 -1.38571467558139 -1 9.74439007257665 4502 508 712 1206 675 2936 4446 3830 2467 584 3686 2463 M10889 GO_COFACTOR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORT.html The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. 13/27 Gene Ontology BP GO:0051181 0.000590446384964406 0.000927730140571822 2635 2349 2468 5.3691355574549e-05 732 1.79954825253018 -1.98216008198114 -1 6.4647764644991 2631 3802 2516 4200 3323 1530 2084 732 949 2468 1604 2464 M10212 GO_VIRAL_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_BUDDING.html A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. 16/25 Gene Ontology BP GO:0046755 0.000214580992599951 0.000364277714311361 675 1945.72727272727 2469 1.95092659095361e-05 133 0.804118768321797 -0.702778173974381 -1 3.27548502717783 673 2469 2899 2945 3465 228 133 631 3973 3419 568 2465 M12721 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. 16/58 Gene Ontology BP GO:0002686 9.43962288846538e-07 4.2305182501105e-06 4375 2871.36363636364 2470 8.5814790352385e-08 927 1.86988118286348 -2.00587969750569 -1 11.9030403617244 4373 2026 1138 1484 927 4232 4150 4240 2470 2257 4288 2466 M13432 GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION.html An organelle organization which involves another organism. 16/25 Gene Ontology BP GO:1902590 0.000178385329740571 0.000306870354199879 675 1938.81818181818 2470 1.62181632383423e-05 134 0.804118768321797 -0.702778173974381 -1 3.34643044846249 674 2470 2900 2946 3466 229 134 538 3974 3427 569 2467 M16138 GO_DEFINITIVE_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFINITIVE_HEMOPOIESIS.html A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. 8/21 Gene Ontology BP GO:0060216 0.000454799759876916 0.00072664669136563 940 2311.27272727273 2470 4.54892865966011e-05 604 2.8025757523086 2.8025757523086 1 10.4203420529754 940 3382 4516 2470 3437 1127 604 696 3875 3407 970 2468 M11306 GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. 13/24 Gene Ontology BP GO:0060644 0.000285277767266325 0.000471613300057105 2395 2473.45454545455 2471 2.59377060399939e-05 1393 2.29432517661201 -3.14325450462493 -1 9.04085045808766 2392 3607 1767 2830 2666 2384 1393 3624 1495 2471 2579 2469 M15650 GO_MULTI_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves another organism. 16/25 Gene Ontology BP GO:1902592 0.000135568376307787 0.000238968857705791 675 1936.81818181818 2471 1.23251573655989e-05 135 0.804118768321797 -0.702778173974381 -1 3.44989286479606 675 2471 2901 2947 3467 230 135 503 3975 3431 570 2470 M16525 GO_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GTPASE_ACTIVITY.html Any process that modulates the rate of GTP hydrolysis by a GTPase. 306/772 Gene Ontology BP GO:0043087 8.21690348494979e-08 1.08928103117624e-06 2530 2005.54545454545 2472 7.46991253804323e-09 14 1.4809157761824 1.54123903749386 1 10.4607544697129 2530 14 1148 1471 78 4098 2472 2650 2515 1164 3921 2471 M15951 GO_ORGANELLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_LOCALIZATION.html Any process in which an organelle is transported to, and/or maintained in, a specific location. 280/627 Gene Ontology BP GO:0051640 9.11525255914148e-07 4.14694819311423e-06 2095 2398.63636363636 2473 8.28659666896652e-08 908 1.57910244017179 1.96136674585271 1 10.0682485023311 2092 4077 2498 4172 908 2538 1587 1013 2473 3228 1799 2472 M15470 GO_CELLULAR_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 144/401 Gene Ontology BP GO:1901653 1.25317190351413e-06 5.1811906928015e-06 2475 2297 2475 1.13924783395543e-07 1032 1.49178553448512 1.37567361932953 1 9.34063235419741 2475 1310 1175 1178 1032 4110 2649 3524 2661 1481 3672 2473 M14527 GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros. 8/26 Gene Ontology BP GO:0072010 0.000238860616331418 0.000401531441573778 2420 2449.72727272727 2476 2.388862946934e-05 947 1.94929744407693 2.01739004770769 1 7.84259279491691 2419 1124 4247 947 2647 3411 1975 3479 2476 1057 3165 2474 M11122 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 11/27 Gene Ontology BP GO:0010875 0.0314980837661605 0.0397730766729081 2375 2642.63636363636 2477 0.00290530029370796 1613 2.07607191740306 2.07607191740306 1 3.44409988891241 2373 2477 2219 1863 3478 3271 4122 1613 2542 2918 2193 2475 M13874 GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. 10/35 Gene Ontology BP GO:0034142 0.000103900538224097 0.000187781315287848 2770 2215.18181818182 2478 9.44594959209426e-06 462 1.87778348311599 2.39857134364419 1 8.28909076484048 2768 2478 2060 2048 2884 3023 1900 462 971 2828 2945 2476 M12698 GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 165/381 Gene Ontology BP GO:0046822 3.75336373257799e-06 1.12474942512075e-05 2265 2679.63636363636 2480 3.41215466919195e-07 1456 1.47819884853104 1.65325753817827 1 8.66609480703452 2263 3566 2480 3616 1456 3239 2237 2332 2048 3417 2822 2477 M12867 GO_OVULATION_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE_PROCESS.html A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 48/121 Gene Ontology BP GO:0022602 1.74234448912706e-05 3.96748674007697e-05 3630 2533.09090909091 2480 1.5839620801898e-06 1245 1.66638348480504 1.68003063890263 1 8.68864691134313 3628 1245 1423 1498 1922 4299 3073 2864 2480 1554 3878 2478 M11116 GO_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_PROLIFERATION.html The expansion of a T cell population by cell division. Follows T cell activation. 21/59 Gene Ontology BP GO:0042098 8.0346189118534e-06 2.06217443934413e-05 1845 2559.09090909091 2481 7.3042256865738e-07 1692 1.44111881824402 1.17555729214913 1 7.99926206659655 3929 1845 2481 2177 1692 3208 3832 1916 1845 2732 2493 2479 M13150 GO_TETRAHYDROFOLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. 9/20 Gene Ontology BP GO:0046653 0.0765897756730953 0.0916038970762961 1295 2572.18181818182 2481 0.00793650793650794 1291 1.44853616387183 1.44853616387183 1 1.78131362075006 1291 2445 4023 2701 3678 2481 1586 2867 2329 2685 2208 2480 M14586 GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. 7/27 Gene Ontology BP GO:0051580 0.000326352057079998 0.000533164180514578 2195 2856.09090909091 2481 3.26399994537792e-05 2119 1.60206355655677 -1.60206355655677 -1 6.21186743286593 2194 2119 4253 2139 2706 2982 3979 2209 3960 2395 2481 2481 M14305 GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. 13/27 Gene Ontology BP GO:0035883 0.000564199120720827 0.00088919773167237 4305 2634.81818181818 2482 5.1303987626821e-05 812 1.58071861748426 -1.0530562876706 -1 5.71314156183411 4305 1811 1961 2250 2795 3861 3220 1869 812 2482 3617 2482 M14805 GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of DNA biosynthetic process. 55/119 Gene Ontology BP GO:2000278 0.0280579359996674 0.0355937149853705 2335 2829.81818181818 2482 0.00258384531367251 1586 1.98130539371345 2.41198402467605 1 3.40005379675333 2335 4545 1630 3662 4068 3464 2346 1586 2482 2709 2301 2483 M16099 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 8/30 Gene Ontology BP GO:0055015 2.43682728505522e-05 5.27714043120866e-05 3825 2659.18181818182 2483 2.4368540070401e-06 237 3.59207063087427 4.45892209265348 1 18.202172975447 3825 2483 4507 1801 2050 4561 3745 424 237 1762 3856 2484 M12049 GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of endothelial cell development. 7/14 Gene Ontology BP GO:1901550 0.102972814648812 0.115903703858044 2450 2667.45454545455 2484 0.010808079462258 1498 1.81990256117796 -1.81990256117796 -1 2.01769988503676 2449 2523 3843 2616 3970 2484 2244 2047 3685 1498 1983 2485 M16241 GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX.html The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. 7/13 Gene Ontology BP GO:0016558 0.00487357557311687 0.00672052610216264 1120 2518.90909090909 2484 0.000488429696304823 651 0.511533139989859 -0.511533139989859 -1 1.31652903931105 1117 2484 4533 3798 3669 651 710 1205 3902 4597 1042 2486 M11279 GO_MONOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 34/87 Gene Ontology BP GO:0046365 0.0121583536620019 0.0159647160782451 1265 2314.27272727273 2485 0.00111146105690081 1224 1.34818257866181 -1.34754558081493 -1 2.86969456440475 2440 3145 2485 3204 3449 1224 1261 1559 2557 2872 1261 2487 M14578 GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. 7/14 Gene Ontology BP GO:1903140 0.102972814648812 0.115903703858044 2450 2705.90909090909 2485 0.010808079462258 1504 1.81990256117796 -1.81990256117796 -1 2.01769988503676 2450 2524 4251 2617 3971 2485 2245 2048 3686 1504 1984 2488 M16037 GO_INACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INACTIVATION_OF_MAPK_ACTIVITY.html Any process that terminates the activity of the active enzyme MAP kinase. 18/28 Gene Ontology BP GO:0000188 5.54264932301845e-07 3.09309144312195e-06 3770 2367.36363636364 2485 5.03877338129661e-08 703 1.35391725453444 1.35597460264828 1 8.83671366261727 3769 1003 1918 2485 703 3554 822 3870 2876 956 4085 2489 M12775 GO_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 56/118 Gene Ontology BP GO:0038127 4.33381994334923e-06 1.25537855639129e-05 3435 2350.36363636364 2486 3.93984407331215e-07 1023 1.71587663702279 -1.8607679404735 -1 9.96250965988142 3433 2494 1273 1023 1510 2671 4361 2486 1909 2740 1954 2490 M13101 GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 7/19 Gene Ontology BP GO:0060192 0.000113896441435049 0.00020394183477938 4465 2728.18181818182 2486 1.13902279435891e-05 577 1.96133288701259 -2.37531355331979 -1 8.57459848098063 4465 1821 4013 1478 2486 4335 4126 1782 577 1500 3427 2491 M10591 GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. 121/338 Gene Ontology BP GO:0070302 1.30238965860407e-06 5.32427050710004e-06 2445 2279.36363636364 2488 1.18399129964843e-07 1045 1.55512596584862 1.75739402023619 1 9.71543621750089 2441 2651 1509 1897 1045 3823 2680 2534 2572 1433 2488 2492 M11657 GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 49/129 Gene Ontology BP GO:0045428 1.30781795177424e-06 5.32681605067737e-06 3120 2433.27272727273 2489 1.18892611747626e-07 940 1.37246600924267 1.1375403676537 1 8.57395548387009 3119 1470 1600 940 1048 3592 2489 4095 2813 1287 4313 2493 M15769 GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to a muscle, across a synapse. 9/40 Gene Ontology BP GO:0007274 0.0410158438982889 0.0510280180117243 1795 2664.63636363636 2489 0.00417931480500107 1041 1.57169881367709 1.37796471328214 1 2.40587985720904 1791 3158 4454 1871 3508 2370 1041 3798 2489 2700 2131 2494 M11231 GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS.html The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 49/987 Gene Ontology BP GO:0007606 0.00715957341832802 0.00966896433429232 1870 2421.09090909091 2490 0.000652998172633006 992 1.89360334144437 1.73523439654201 1 4.51918480393388 1866 2686 992 2424 3266 3392 2344 2490 2703 1286 3183 2495 M13532 GO_TETRAPYRROLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 32/86 Gene Ontology BP GO:0033013 0.000135734547769605 0.000239170969751148 2940 2378.54545454545 2490 1.23402657252949e-05 505 1.7176487846029 2.03928727045728 1 7.36844520872594 2938 2544 2197 2490 2526 4295 2714 505 1374 2273 2308 2496 M15053 GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT.html The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. 9/24 Gene Ontology BP GO:0061377 7.0104775235339e-05 0.000131940199196465 3895 2488.63636363636 2490 7.01069869393183e-06 775 2.21070787979467 -2.63574389466613 -1 10.160121446138 3894 2036 4340 1057 2367 3948 3115 2517 836 775 2490 2497 M10095 GO_REGULATION_OF_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_BURST.html Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 6/20 Gene Ontology BP GO:0060263 1.45238593109385e-05 3.38865722516017e-05 4215 2656.54545454545 2491 1.45239542359318e-06 1291 1.54950632536828 -1.74329668323859 -1 8.20495500401115 4211 1824 3531 2491 1894 4187 3474 2040 1361 1291 2918 2498 M12647 GO_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BACTERIUM.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. 277/948 Gene Ontology BP GO:0009617 2.63616731462746e-10 7.46324685476543e-09 4025 2464.54545454545 2491 2.39651574085759e-11 152 1.76382348056458 -1.80633437887439 -1 16.9811577341283 4022 1055 152 1566 1125 3963 4353 3424 2491 535 4424 2499 M15431 GO_STRIATUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATUM_DEVELOPMENT.html The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. 10/37 Gene Ontology BP GO:0021756 0.000129642275613498 0.00022970915472663 4630 2799.36363636364 2491 1.17863559857865e-05 1220 1.63700406863458 -2.01026477322431 -1 7.05648678390073 4628 1505 2131 1220 2491 3911 4493 3356 1434 1376 4248 2500 M16615 GO_RESPONSE_TO_LEAD_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEAD_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. 13/30 Gene Ontology BP GO:0010288 0.00013903150959067 0.000244423816368603 2030 2335.18181818182 2491 1.26400269657231e-05 1015 1.35727526944788 1.59629047543774 1 5.80732854709472 2029 1015 1965 1615 2509 3033 3241 1928 3153 2491 2708 2501 M11565 GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 32/95 Gene Ontology BP GO:0051196 0.00150297164636291 0.00219996763999464 1935 2713.72727272727 2492 0.00013672721936569 1396 1.05820100992045 0.964238183906561 1 3.33144775366015 1933 2836 2492 3489 2995 2350 2276 1396 3899 3944 2241 2502 M13637 GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. 68/218 Gene Ontology BP GO:0002706 0.00012544116662023 0.000222809233595152 2650 2519.54545454545 2492 1.14043926986367e-05 1497 1.6406461257198 -1.50004707756828 -1 7.09792866777986 2650 3423 1497 3315 2487 2108 3129 1948 2797 1869 2492 2503 M16379 GO_SUBPALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBPALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. 10/44 Gene Ontology BP GO:0021544 0.000129642275613498 0.00022970915472663 4630 2801.36363636364 2492 1.17863559857865e-05 1221 1.63700406863458 -2.01026477322431 -1 7.05648678390073 4629 1506 2132 1221 2492 3912 4494 3366 1435 1379 4249 2504 M13288 GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. 8/17 Gene Ontology BP GO:0030007 1.30538242331217e-05 3.09674449907567e-05 4300 2480.45454545455 2493 1.30539009148029e-06 719 1.8273092380515 -2.28976312783162 -1 9.76066541552684 4297 1510 4044 1179 1866 3642 2493 719 758 2527 4250 2505 M15443 GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 32/95 Gene Ontology BP GO:0051193 0.00150297164636291 0.00219996763999464 1935 2718.09090909091 2493 0.00013672721936569 1433 1.05820100992045 0.964238183906561 1 3.33144775366015 1934 2837 2493 3490 2996 2351 2277 1433 3900 3946 2242 2506 M16528 GO_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCONEOGENESIS.html Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. 28/84 Gene Ontology BP GO:0006111 8.19071738574504e-05 0.000151511955466192 2350 2535.09090909091 2494 7.44638395129013e-06 1209 1.29101745528151 1.40433902297323 1 5.84147661574295 2346 2588 2494 3808 2384 3454 2012 1209 3279 2871 1441 2507 M10968 GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 48/99 Gene Ontology BP GO:0061180 7.10891090965587e-06 1.8647838052843e-05 3370 2466.36363636364 2495 6.46266716449828e-07 567 2.00244494482271 1.87172783766713 1 11.2186875295221 3367 2495 817 567 1664 4544 3440 4518 637 812 4269 2508 M14189 GO_DRUG_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORT.html The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/52 Gene Ontology BP GO:0015893 9.92225310677919e-05 0.000180027437181617 4645 2856.54545454545 2495 9.02063694551631e-06 1679 1.74546356040646 -1.57734841663341 -1 7.74285874607881 4642 2355 1710 2743 2435 4125 2495 3292 1679 2005 3941 2509 M15972 GO_MATERNAL_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PLACENTA_DEVELOPMENT.html Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 16/41 Gene Ontology BP GO:0001893 0.00092152432813198 0.00139233239684894 3250 2379.90909090909 2498 8.38100507151899e-05 1168 1.85751026075852 -2.39968000991547 -1 6.28501761985317 3246 3218 1168 3203 2910 2001 3197 1214 2498 1623 1901 2510 M14227 GO_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of B cell activation. 56/269 Gene Ontology BP GO:0050864 9.57215765858941e-05 0.000174192643794418 2210 2514.54545454545 2499 8.70234015154376e-06 776 1.3252172201773 -1.14488963417282 -1 5.90111298650645 2210 3426 2499 3767 2427 776 1622 2800 3195 3352 1586 2511 M14300 GO_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 40/100 Gene Ontology BP GO:0046631 5.5483191414706e-05 0.000107292152327563 2745 2527 2499 5.0440537027098e-06 1901 1.34782498689824 -1.16066611751206 -1 6.33781941992028 2742 2499 2004 2376 2279 1901 2997 3005 2893 2052 3049 2512 M12206 GO_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_FORMATION.html The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. 17/47 Gene Ontology BP GO:0048645 2.80890753784022e-05 5.93886962577056e-05 2555 2348.09090909091 2500 2.55358491085719e-06 813 2.55688039659173 -1.99570160159712 -1 12.8011324246375 2500 2553 813 2551 2071 3234 2195 2665 1511 2323 3413 2513 M13217 GO_SPERM_EGG_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_EGG_RECOGNITION.html The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. 18/76 Gene Ontology BP GO:0035036 0.00232977383428143 0.00332425934621041 1600 2256.36363636364 2500 0.000212022245555053 413 1.49307841464229 -1.6397634058727 -1 4.38344258880727 1597 4094 2500 4285 3262 600 413 1189 2978 3021 881 2514 M13887 GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 14/43 Gene Ontology BP GO:0010800 0.000134283846534776 0.000237064600555501 4375 2592.45454545455 2501 1.22083676061573e-05 120 1.91194434162478 -1.3884086466021 -1 8.21064429458459 4375 835 1560 926 2501 3921 4039 4414 120 1394 4432 2515 M13970 GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of T cell cytokine production. 24/76 Gene Ontology BP GO:0002724 0.0839184282471183 0.0949861682962873 1595 2695.72727272727 2501 0.00793650793650794 1384 1.55097050443125 -1.40758726498971 -1 1.87834969286677 1592 3796 2457 3280 4354 1384 2501 2055 3305 2962 1967 2516 M14158 GO_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. 71/157 Gene Ontology BP GO:0045444 1.04645826018789e-05 2.57619602441801e-05 1700 2685.81818181818 2501 9.51330216212886e-07 1697 1.27056284377215 1.28798767224698 1 6.90707545905973 1697 3305 2501 3648 1768 2610 2305 3517 3446 2317 2430 2517 M13196 GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of the same species. 11/65 Gene Ontology BP GO:0051703 1.33600402555389e-05 3.15677694180493e-05 4600 2592.18181818182 2502 1.21455648985036e-06 1018 1.36182901627296 -0.735045434022753 -1 7.2608265732455 4598 1018 2502 1266 1843 4223 2799 1508 1586 2931 4240 2518 M14120 GO_SOCIAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOCIAL_BEHAVIOR.html Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. 11/65 Gene Ontology BP GO:0035176 1.33600402555389e-05 3.15677694180493e-05 4600 2592.27272727273 2503 1.21455648985036e-06 1019 1.36182901627296 -0.735045434022753 -1 7.2608265732455 4599 1019 2503 1267 1844 4224 2800 1498 1587 2933 4241 2519 M16326 GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. 12/22 Gene Ontology BP GO:2000479 0.000831487726043672 0.00126549792668264 2505 2737.27272727273 2503 7.5618377486801e-05 1848 1.29321088671464 1.20780700533075 1 4.43921816989304 2503 2476 2228 1848 2888 3263 2533 4552 2468 2363 2988 2520 M16861 GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION.html A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. 13/22 Gene Ontology BP GO:0042772 0.000505301417990335 0.000802364734517484 2610 2176.36363636364 2504 4.59470467452291e-05 170 2.74635511435397 -1.86311902770764 -1 10.0712531238368 2610 2844 1524 2984 2770 2504 2141 1271 170 2495 2627 2521 M11953 GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. 10/21 Gene Ontology BP GO:0051560 0.024315282542485 0.0309728002317579 2070 2819.63636363636 2505 0.00223529619157543 2060 1.51637442128443 1.36394654107603 1 2.71068556040279 2067 3475 2168 3557 3415 2103 2465 3815 3386 2060 2505 2522 M14334 GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 12/32 Gene Ontology BP GO:0071236 0.00986212105089009 0.0130940314667666 1885 2573.90909090909 2505 0.00090060093215901 1191 1.4725705742286 1.4725705742286 1 3.28463708910069 1885 3319 2505 2116 3544 2693 1768 1919 3673 3700 1191 2523 M10225 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. 9/34 Gene Ontology BP GO:2000678 0.000347694277131236 0.00056564279212345 1970 2430 2506 3.4774869020338e-05 1632 1.19480958551232 -1.02719472535562 -1 4.59642469653072 1969 1652 3556 2506 2719 1632 1965 2277 3143 2666 2645 2524 M13591 GO_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 58/157 Gene Ontology BP GO:0006633 1.69042320641691e-06 6.3295443124143e-06 3245 2342.36363636364 2506 1.53674955026897e-07 1138 1.43285246512756 -1.28129597349705 -1 8.82405484050422 3245 2254 1646 2892 1147 1138 1432 3244 2506 3189 3073 2525 M15934 GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION.html The directed movement of the mitochondrion to a specific location. 14/23 Gene Ontology BP GO:0051654 0.034300784028717 0.0431010934358141 1325 2405.09090909091 2506 0.0031679590207053 1325 1.22334714685321 1.24646725053994 1 1.97889556627114 1325 2559 2506 2987 3457 2028 1424 3415 2774 2010 1971 2526 M12536 GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of T cell death by apoptotic process. 23/41 Gene Ontology BP GO:0070232 0.000195545532933031 0.000334408069763559 2920 2256.54545454545 2509 1.77784469118622e-05 851 1.95638658279808 -1.57061045107024 -1 8.055228711551 2916 1690 851 2368 2583 2509 3084 3215 1074 1034 3498 2527 M12691 GO_SPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 73/149 Gene Ontology BP GO:0006665 3.44831995814192e-06 1.05643589159469e-05 3530 2790.54545454545 2510 3.13484123919374e-07 1317 1.35412269058332 -1.16088412277336 -1 7.98233751235122 3527 1317 2312 2188 1420 4063 2972 4572 2510 1867 3948 2528 M10049 GO_REGULATION_OF_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING_BY_RNA.html Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. 8/27 Gene Ontology BP GO:0060966 0.000226357474376094 0.000382451875374165 1100 2272.72727272727 2512 2.26380534649871e-05 586 1.64787949494434 -1.64787949494434 -1 6.67117304371097 1099 3696 3524 3357 3786 1188 1305 586 2857 2512 1090 2529 M11217 GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. 38/75 Gene Ontology BP GO:0070228 1.04021234707742e-05 2.56353817806818e-05 3480 2661.45454545455 2512 9.45652059528603e-07 1166 1.85663123921629 -1.57061045107024 -1 10.0977852604975 3477 2307 1166 2512 1766 4190 3625 3949 1584 1522 3178 2530 M12396 GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. 38/132 Gene Ontology BP GO:0040014 1.5600004279666e-06 6.01584882645259e-06 1110 2421.90909090909 2512 1.41818321286375e-07 666 1.68520686107103 -1.62948264026558 -1 10.4222202012476 4290 666 2310 1106 1106 3682 3702 2512 1222 3074 2971 2531 M16829 GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). 7/71 Gene Ontology BP GO:0030520 0.000648068897966638 0.00100735985713395 3725 2652.18181818182 2512 6.48257972559142e-05 154 1.50527150202116 -2.16144662965864 -1 5.3438319289708 3722 2209 4623 1216 2846 4001 3766 1714 154 2411 2512 2532 M10068 GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0052192 3.89267743369653e-07 2.57804519639595e-06 2515 2628.90909090909 2513 3.53879829315144e-08 529 1.60018956206274 1.63141090985741 1 10.5940251475564 2513 2578 1404 1994 529 4399 3889 4565 2362 1595 3090 2533 M16279 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that activates or increases the activity of the enzyme nitric-oxide synthase. 15/27 Gene Ontology BP GO:0051000 0.000142166706640512 0.000249274931620807 2440 2515.36363636364 2513 1.29250813144756e-05 1684 2.05349115306716 2.00019421571498 1 8.76544269304113 2438 2956 1684 2337 2513 3326 2486 2627 1720 2725 2857 2534 M10524 GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0051806 3.89267743369653e-07 2.57804519639595e-06 2515 2629.09090909091 2514 3.53879829315144e-08 530 1.60018956206274 1.63141090985741 1 10.5940251475564 2514 2579 1405 1995 530 4400 3890 4557 2363 1596 3091 2535 M10580 GO_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. 8/22 Gene Ontology BP GO:0046209 0.0108349011712246 0.0142834883980681 2635 2550.81818181818 2514 0.00108880943404313 1327 1.56223518020466 -1.96411311342095 -1 3.41475600454549 2634 2330 3607 1327 3324 2342 3105 1883 3098 2514 1895 2536 M13762 GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. 13/45 Gene Ontology BP GO:0031664 0.00040943379588376 0.000657785852694913 1105 2128.45454545455 2514 3.72281830854487e-05 657 1.54009493095261 -1.54009493095261 -1 5.80515881618082 1105 3438 2691 2720 3145 973 1705 657 2514 3176 1289 2537 M15397 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein. 23/68 Gene Ontology BP GO:0042516 0.000124675921732359 0.000221874398084838 3590 2538.45454545455 2514 1.13348170714883e-05 1035 1.57400584473947 1.54943304062513 1 6.81302743370462 3588 1409 2040 2514 2482 2150 2956 4161 2777 1035 2811 2538 M12462 GO_PROTEIN_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DESTABILIZATION.html Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. 21/51 Gene Ontology BP GO:0031648 2.39875643731176e-06 8.07645115187709e-06 3080 2641.18181818182 2515 2.1806900479864e-07 1288 1.27024718285571 -1.5714424603599 -1 7.66339328050912 3078 2269 2515 3410 1288 2392 3184 1874 3236 3712 2095 2539 M12914 GO_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_ENTRY_INTO_HOST_CELL.html The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. 54/135 Gene Ontology BP GO:0046718 3.89267743369653e-07 2.57804519639595e-06 2515 2630.27272727273 2515 3.53879829315144e-08 531 1.60018956206274 1.63141090985741 1 10.5940251475564 2515 2580 1406 1996 531 4401 3891 4560 2364 1597 3092 2540 M13798 GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION.html The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. 50/170 Gene Ontology BP GO:0099531 8.58230054702623e-06 2.18223556625645e-05 2985 2542.90909090909 2515 7.80212184286886e-07 1674 1.33228322654472 -1.16995583198554 -1 7.35635757588928 2981 2392 1927 2096 1710 2931 2515 3363 2907 1674 3476 2541 M12938 GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0051828 3.89267743369653e-07 2.57804519639595e-06 2520 2631.27272727273 2516 3.53879829315144e-08 532 1.60018956206274 1.63141090985741 1 10.5940251475564 2516 2581 1407 1997 532 4402 3892 4561 2365 1598 3093 2542 M10107 GO_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 258/813 Gene Ontology BP GO:0050865 6.87178856543417e-06 1.8066655894287e-05 430 2507.90909090909 2517 6.24710002712387e-07 427 1.58577295103408 -1.42241295964112 -1 8.9101156625955 4428 1830 427 1408 1659 2736 3944 4242 2517 428 3968 2543 M15136 GO_MOVEMENT_IN_HOST_ENVIRONMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_HOST_ENVIRONMENT.html The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0052126 3.89267743369653e-07 2.57804519639595e-06 2520 2632.72727272727 2517 3.53879829315144e-08 533 1.60018956206274 1.63141090985741 1 10.5940251475564 2517 2582 1408 1998 533 4403 3893 4567 2366 1599 3094 2544 M13769 GO_MICROGLIAL_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROGLIAL_CELL_ACTIVATION.html The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 18/50 Gene Ontology BP GO:0001774 3.04168055369732e-05 6.33349745501833e-05 4100 2940.27272727273 2518 2.76520237112845e-06 1989 1.41504310898818 0.883299849356783 1 7.03763877562417 4099 3370 2265 2518 2099 3549 4455 2324 1989 2445 3230 2545 M15286 GO_ENTRY_INTO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST.html Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0044409 3.89267743369653e-07 2.57804519639595e-06 2520 2632.90909090909 2518 3.53879829315144e-08 534 1.60018956206274 1.63141090985741 1 10.5940251475564 2518 2583 1409 1999 534 4404 3894 4559 2367 1600 3095 2546 M14633 GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 8/21 Gene Ontology BP GO:0010649 0.00017548327625987 0.000302213965754665 1390 2354.27272727273 2519 1.75497135271288e-05 449 1.48692200468201 1.9411464168654 1 6.19969076372086 1386 2519 4263 1923 2939 934 1646 4609 2693 2536 449 2547 M16749 GO_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST_CELL.html The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0030260 3.89267743369653e-07 2.57804519639595e-06 2520 2633.72727272727 2519 3.53879829315144e-08 535 1.60018956206274 1.63141090985741 1 10.5940251475564 2519 2584 1410 2000 535 4405 3895 4558 2368 1601 3096 2548 M11356 GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 10/23 Gene Ontology BP GO:0060390 0.0581768212105374 0.0711953033422575 2525 2671 2521 0.00543406632920549 1730 1.33994369693032 -0.844863202292802 -1 1.82152593530957 2521 3260 2232 3062 3547 2866 1730 2357 2104 3568 2134 2549 M15713 GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-2 production. 27/66 Gene Ontology BP GO:0032663 0.000146859310223935 0.000256630702811341 3550 2825.63636363636 2521 1.33517376927892e-05 1253 1.5391931305756 -1.46182638757117 -1 6.54710319755702 3550 2060 1253 1874 2521 3780 3180 4519 2294 1411 4640 2550 M16934 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. 6/21 Gene Ontology BP GO:0023019 0.0155330419752818 0.0202016565521662 1830 2807.54545454545 2521 0.0015642696184301 673 3.2192329663136 3.2192329663136 1 6.46250560899318 1828 3955 4639 2521 3716 2474 673 2422 3823 3161 1671 2551 M11060 GO_3_UTR_MEDIATED_MRNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_UTR_MEDIATED_MRNA_STABILIZATION.html An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. 11/16 Gene Ontology BP GO:0070935 0.000885600874522062 0.00134286246257542 2895 2598.36363636364 2522 8.05415973198145e-05 1011 1.41753156885651 -1.63596245979767 -1 4.8227012183243 2894 1812 2522 1828 2900 2337 2307 4246 1011 2917 3808 2552 M11739 GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT.html The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. 8/21 Gene Ontology BP GO:0060712 3.98291418107626e-05 8.02633270084075e-05 3965 2576.90909090909 2522 3.98298556910121e-06 157 1.60235124866381 -2.16202261970506 -1 7.77393386530095 3962 1656 3798 1171 2206 3788 4259 1707 157 2522 3120 2553 M15754 GO_RESPONSE_TO_MERCURY_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MERCURY_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. 7/20 Gene Ontology BP GO:0046689 1.77936586235527e-06 6.54417064190877e-06 3900 2769.36363636364 2523 1.77936728712117e-07 942 1.92270596343636 -1.36657155556823 -1 11.807775450853 3898 942 4453 1426 1201 3436 4532 4599 1050 2403 2523 2554 M15527 GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of JUN kinase activity. 41/121 Gene Ontology BP GO:0043507 2.80706152012309e-06 9.0320073720939e-06 2860 2667 2525 2.55187736523936e-07 1350 1.51852054515871 1.4701757159857 1 9.07386564187209 2857 2258 1973 1510 1350 3835 2618 4162 2525 2151 4098 2555 M11996 GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 70/157 Gene Ontology BP GO:0002224 9.8560980329976e-06 2.44323882366299e-05 3380 2680.54545454545 2527 8.9601292627572e-07 1755 1.34900766551549 -1.38737135328465 -1 7.37029596216235 3378 2336 2063 2860 1755 2527 3737 3307 2752 2277 2494 2556 M14016 GO_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MATURATION.html Any process that modulates the frequency, rate or extent of protein maturation. 42/138 Gene Ontology BP GO:1903317 0.000702308860673866 0.00108477047242474 2675 2425.63636363636 2527 6.3866650899613e-05 1609 1.65986421101848 1.89619250068652 1 5.8294253525441 2672 2135 1609 2988 2839 2859 2527 2041 1701 1862 3449 2557 M14714 GO_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_HOMEOSTASIS.html Any process involved in the balance between food intake (energy input) and energy expenditure. 9/20 Gene Ontology BP GO:0097009 0.189467204757072 0.208953974272467 2135 2873.72727272727 2527 0.0207872510666369 1291 0.805353815478957 0.861493775568844 1 0.648694578570337 2135 1291 4280 3200 4610 2331 1358 2393 3982 3504 2527 2558 M14821 GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 25/58 Gene Ontology BP GO:0010799 0.000133020285997857 0.000235102089032375 2530 2347.90909090909 2528 1.20934845078403e-05 493 1.44073862053602 1.4756252698253 1 6.19326201867696 2528 991 2135 1371 2498 3396 2651 4056 493 2604 3104 2559 M12220 GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. 6/20 Gene Ontology BP GO:1902991 8.66025424464414e-05 0.000159561747848741 3555 2595.27272727273 2529 8.6605917631727e-06 447 2.74607937325988 -2.38236779657299 -1 12.3520736093223 3551 1823 3871 1617 2424 2598 3722 2529 447 2181 3785 2560 M13734 GO_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_BURST.html A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 8/26 Gene Ontology BP GO:0045730 2.5465969060668e-05 5.47907758798339e-05 2955 2692.45454545455 2530 2.5466260897386e-06 1584 1.47255826285696 -0.693790417555284 -1 7.43347424646313 2953 1584 4124 2498 2070 3227 3523 1588 2414 2530 3106 2561 M10223 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein. 3/14 Gene Ontology BP GO:0042511 0.00101467070560076 0.00151922479397108 2805 2411.27272727273 2531 0.000101513430403668 1222 2.31589561865601 -2.31589561865601 -1 7.73207792644433 2801 1222 3555 2430 2949 2593 2531 1789 1937 2576 2141 2562 M13017 GO_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 36/99 Gene Ontology BP GO:0043550 0.000437994090228137 0.000701243641699738 1240 2319.27272727273 2531 3.98255740004961e-05 1163 1.48583795552204 1.5129549737307 1 5.55174044584992 1239 3278 1913 2531 2745 1994 1163 1804 3106 2955 2784 2563 M11577 GO_VENTRICULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. 21/67 Gene Ontology BP GO:0021591 2.82078623205242e-06 9.0576367324632e-06 2535 2365.72727272727 2533 2.56435440800189e-07 105 2.80551710007808 3.39993932557369 1 16.7601794132985 2533 4293 1782 2595 4003 3038 2371 105 1163 3256 884 2564 M13302 GO_ONE_CARBON_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_METABOLIC_PROCESS.html The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. 20/37 Gene Ontology BP GO:0006730 1.51894802090248e-05 3.52447559272874e-05 2135 2438.63636363636 2534 1.38087137117329e-06 576 1.59379740911976 1.57556027928642 1 8.40726252999666 2134 576 1650 1644 1878 3537 3031 4633 2565 2643 2534 2565 M13813 GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. 8/19 Gene Ontology BP GO:0060575 0.0406956328326634 0.050643211804357 2540 2837.18181818182 2537 0.00414606869788757 1240 1.91532858618835 -1.69834478895059 -1 2.93935093406595 2537 3984 4135 3302 3763 2051 1240 1702 3457 2531 2507 2566 M13213 GO_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE.html Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. 298/1073 Gene Ontology BP GO:0045087 1.41804343216377e-06 5.65633647382851e-06 4170 2717.27272727273 2539 1.28913122380549e-07 1072 1.4960911728275 -1.33821973944616 -1 9.30005709313685 4167 1829 1157 2539 1072 2015 4180 4550 2966 2097 3318 2567 M15587 GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS.html The process in which any suture between cranial and/or facial bones is generated and organized. 8/20 Gene Ontology BP GO:0097094 0.00011856785654783 0.000211816297788216 3565 2622.18181818182 2539 1.185741832744e-05 1254 1.59448740534755 -1.83018750380093 -1 6.93973751017461 3565 1771 4429 2133 2493 3117 3101 1254 1263 2539 3179 2568 M11468 GO_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORELIMB_MORPHOGENESIS.html The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 19/58 Gene Ontology BP GO:0035136 4.76180894797694e-06 1.35058515244086e-05 2385 2405.81818181818 2540 4.32892659522415e-07 1430 1.63517163424195 1.380217598267 1 9.43243409783997 2381 2349 1430 2540 1539 2938 1509 2921 2819 2556 3482 2569 M15829 GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING.html Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. 8/27 Gene Ontology BP GO:0060147 0.000201139437690667 0.000343215879896276 1100 2360 2541 2.01157645693224e-05 569 1.64787949494434 -1.64787949494434 -1 6.7629404498408 1100 3697 4464 3358 3787 1189 1306 569 2858 2541 1091 2570 M14646 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that stops, prevents, or reduces the rate of leukocyte degranulation. 7/18 Gene Ontology BP GO:0043301 8.37752385714534e-06 2.13718919058933e-05 4570 2814 2542 8.3775554396206e-07 1402 1.910071331567 -2.80495818778103 -1 10.5671799342151 4566 2174 4265 2392 1734 4489 2720 2542 1402 1506 3164 2571 M15859 GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). 8/19 Gene Ontology BP GO:0048016 0.0525662375623167 0.064618755891405 1260 2559.18181818182 2542 0.00538527236853895 1256 2.08260746517421 2.08260746517421 1 2.93495431738725 1256 3160 4468 3392 3546 1785 1711 1940 2578 2542 1773 2572 M16632 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 36/106 Gene Ontology BP GO:0042346 8.42562660936692e-05 0.00015548562936125 2695 2533.63636363636 2542 7.65995392169873e-06 1811 1.50567520970525 -1.93224831474352 -1 6.79268629407432 2692 3032 2581 2732 2388 2451 2542 1811 2328 2957 2356 2573 M10533 GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 21/84 Gene Ontology BP GO:0090207 0.00661155889430787 0.00896538199365404 2240 2526.36363636364 2544 0.000602864755468845 1284 1.41756446092189 1.18056538146028 1 3.43819119099784 2237 2949 1972 3444 3250 1284 2482 2544 3507 2730 1391 2574 M10140 GO_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 55/151 Gene Ontology BP GO:0016052 0.0229160488470453 0.0292788152990731 2195 2492 2545 0.00210529921006965 1638 1.38068845604057 -1.36639620358665 -1 2.50808431830537 2193 3202 2696 3391 3407 1638 2038 1642 2545 3012 1648 2575 M11389 GO_RELAXATION_OF_CARDIAC_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_CARDIAC_MUSCLE.html The process in which the extent of cardiac muscle contraction is reduced. 14/30 Gene Ontology BP GO:0055119 1.96522266454375e-05 4.38047471506319e-05 3130 2641.09090909091 2545 1.78658201796713e-06 1350 1.63915504811227 -2.28976312783162 -1 8.46316856469528 3127 1350 1968 2364 1963 2545 1960 4384 2809 2619 3963 2576 M16674 GO_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_ASSEMBLY.html The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 6/22 Gene Ontology BP GO:0046847 0.00302606341878254 0.00426145358004469 2445 2865.36363636364 2545 0.000303019201037139 1689 1.6609755346686 -1.6609755346686 -1 4.66412904404693 2444 3355 4602 3633 3144 2128 2123 1689 3651 2205 2545 2577 M16226 GO_NEGATIVE_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_SILENCING.html Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 8/26 Gene Ontology BP GO:0060969 0.000143058837237701 0.000250649879733828 1550 2516.63636363636 2546 1.43068047696126e-05 522 1.64787949494434 -1.64787949494434 -1 7.02940276605424 1549 4449 4531 3878 3872 1458 1196 522 2903 2546 779 2578 M15016 GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 20/45 Gene Ontology BP GO:0002753 0.000258313201338248 0.000430336632154104 1485 1976.36363636364 2547 2.34857760175471e-05 497 1.15271600407052 -1.08143078195125 -1 4.5966253548902 1485 2786 2944 2547 3194 555 643 1330 3109 2650 497 2579 M16316 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. 10/23 Gene Ontology BP GO:0002888 3.15764134038071e-05 6.54213687790612e-05 2950 2872.72727272727 2548 2.8706242387725e-06 2037 1.33596332499209 1.33596332499209 1 6.62206294752867 2948 2037 2484 2548 2114 4514 4041 2329 2428 3597 2560 2580 M12488 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. 18/44 Gene Ontology BP GO:1904036 1.71818531272197e-05 3.91713300417575e-05 4265 2880 2549 1.56199884707389e-06 921 1.14941248512789 -0.973007489511075 -1 6.0006744064006 4261 921 2022 1755 1916 4615 2549 3696 3349 2440 4156 2581 M13670 GO_PIGMENT_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. 14/29 Gene Ontology BP GO:0048753 0.000730511813798348 0.00112533721017443 1065 2131 2549 6.64322266973418e-05 850 0.813656046656824 -0.840738189881451 -1 2.84218171907309 1061 2596 2967 2549 2856 850 1487 875 3777 3244 1179 2582 M11477 GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 7/20 Gene Ontology BP GO:0010763 0.0765897756730953 0.0916038970762961 2555 2694.36363636364 2552 0.00793650793650794 1339 1.17257825648781 0.878098069726888 1 1.44195858390319 2552 2900 3754 1339 4523 2368 1614 3359 1500 2376 3353 2583 M12687 GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE.html The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. 6/60 Gene Ontology BP GO:0050912 3.89207238077309e-05 7.86717112056137e-05 4445 2475 2552 3.89214054947682e-06 486 1.27381857841666 1.39320458804207 1 6.19315729747158 4442 486 3950 1869 2201 2754 1641 2632 2552 1303 3395 2584 M13583 GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 12/25 Gene Ontology BP GO:0090201 5.01451383949735e-05 9.84040057345148e-05 3365 2473.90909090909 2552 4.55875285471444e-06 1283 1.15221956782706 -0.915707407181435 -1 5.46929277552351 3361 1283 2552 1853 2246 2372 1977 2713 2674 3051 3131 2585 M12822 GO_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 107/316 Gene Ontology BP GO:1901654 1.19773956947087e-05 2.88888562132636e-05 2555 2532.27272727273 2553 1.08886008212645e-06 384 1.7242653362154 1.644487538395 1 9.27188641888164 2553 1607 384 1548 1987 4244 3991 4310 2659 929 3643 2586 M14100 GO_REGULATION_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. 592/1431 Gene Ontology BP GO:0032880 5.18563202551386e-06 1.44345860278542e-05 2545 2837 2553 5.18564412640437e-07 1595 1.47774285402071 1.66333808067497 1 8.4737508612698 2545 3135 4186 2971 1595 4003 2553 3088 2435 2214 2482 2587 M13904 GO_METANEPHRIC_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 17/42 Gene Ontology BP GO:0072210 0.000163206103432949 0.000282116879463582 2565 2206 2555 1.48380192789839e-05 1093 1.52419849596833 1.55274510140613 1 6.40907531656818 2564 1102 1207 1093 2555 3389 2830 3078 1858 1238 3352 2588 M10854 GO_LUNG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_CELL_DIFFERENTIATION.html The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. 16/33 Gene Ontology BP GO:0060479 1.00863822261648e-05 2.49234021692831e-05 4455 3090 2559 9.16948042699251e-07 1741 2.07828957286898 -2.02038079965096 -1 11.3334496140868 4453 3602 1741 2245 1759 4365 4397 2322 2559 2252 4295 2589 M11212 GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. 30/66 Gene Ontology BP GO:0045806 0.00205329419972776 0.00294970450783911 2225 2677.45454545455 2559 0.000186837552625425 1591 1.21414044956133 -1.19193684260381 -1 3.63919534835535 2222 3313 2559 3185 3060 2072 3378 1591 3308 2553 2211 2590 M16522 GO_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. 101/270 Gene Ontology BP GO:0042594 1.69495429730557e-06 6.33192045012837e-06 4025 2654.09090909091 2560 1.54086873014274e-07 1149 1.87022270447413 -1.29568542496461 -1 11.5171878387264 4024 3303 1183 2219 1149 2560 4017 2153 1654 2903 4030 2591 M13565 GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. 20/52 Gene Ontology BP GO:0002726 0.0839184282471183 0.0949861682962873 1895 2658.90909090909 2561 0.00793650793650794 1876 1.55097050443125 -1.40758726498971 -1 1.87834969286677 1895 3495 2313 2561 3862 1876 2754 2310 3148 2645 2389 2592 M16322 GO_REGULATION_OF_MYOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of myoblast proliferation. 6/25 Gene Ontology BP GO:2000291 0.000152688783431766 0.000265518360102506 4585 2912.18181818182 2561 1.52699275685475e-05 854 1.56047788383693 1.33190372867129 1 6.61030708621269 4584 854 4550 2130 2561 4139 4552 1958 1311 1317 4078 2593 M14562 GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 11/34 Gene Ontology BP GO:0045663 0.0687680409056234 0.083583773278746 3030 2566.45454545455 2562 0.0064560588144598 1542 1.86363522125555 1.81230489695133 1 2.37962390570079 3030 2562 1697 2409 3692 3358 2816 1829 2316 1542 2980 2594 M12725 GO_RESPONSE_TO_INSULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSULIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 111/299 Gene Ontology BP GO:0032868 2.31551481657173e-06 7.89630384264878e-06 3295 2691.72727272727 2563 2.10501568515478e-07 1271 1.39773304515959 1.38712500091266 1 8.4487360573413 3291 1375 1702 1330 1271 4500 3030 4239 2563 1893 4415 2595 M10716 GO_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROPTOTIC_PROCESS.html A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. 24/46 Gene Ontology BP GO:0070266 2.9345795635264e-05 6.14580645622601e-05 3675 2615.72727272727 2564 2.667835189644e-06 1407 1.29429593898342 -1.3848651891522 -1 6.45714067310905 3675 1407 2393 1932 2091 2564 3806 2003 2662 2961 3279 2596 M11006 GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. 10/18 Gene Ontology BP GO:0009208 0.0109825936626596 0.0144699722973123 1785 2703.63636363636 2564 0.00100343690902712 1603 0.686185989175764 -0.711939850730658 -1 1.49529498734908 1782 2564 2977 3741 3311 1603 1675 1783 3912 4238 2154 2597 M10779 GO_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. 8/21 Gene Ontology BP GO:0043501 0.000149426337741921 0.000260626027849638 2815 2329.18181818182 2565 1.4943638639659e-05 172 3.68727363889083 5.02790383837703 1 15.6548629304264 2811 2707 3632 1750 2558 3425 2565 1693 172 1727 2581 2598 M12759 GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of female gonad development. 3/17 Gene Ontology BP GO:2000194 0.000155989633266647 0.000270751352245623 3870 2961.72727272727 2565 1.56000584093091e-05 1135 1.65413361988582 -2.21720595069278 -1 6.99043124916004 3867 1135 3956 2190 2565 4269 4535 2152 1923 1419 4568 2599 M15039 GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 31/65 Gene Ontology BP GO:0009066 1.64761228016951e-05 3.77957698459834e-05 4145 2970.54545454545 2565 1.49784056319e-06 1770 1.39472980014133 -1.23030257493445 -1 7.30704028583705 4145 2264 2041 2565 1905 4252 4287 3371 2169 1770 3907 2600 M10201 GO_INORGANIC_ION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_IMPORT_INTO_CELL.html The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 10/26 Gene Ontology BP GO:0099587 0.0016362522711339 0.00238528078332016 2175 2537.63636363636 2566 0.000148860954920493 1955 1.75733049630853 -1.75733049630853 -1 5.45934283047615 2226 3261 2172 2812 3020 2566 2850 2077 1955 2803 2172 2601 M14396 GO_MRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION.html The cellular synthesis of messenger RNA (mRNA) from a DNA template. 12/33 Gene Ontology BP GO:0009299 0.005060869602278 0.00697051841096908 1860 2553.18181818182 2566 0.000461140839547738 920 1.43226303933145 1.43226303933145 1 3.65929529462629 1860 2894 2011 3587 3480 1944 920 2566 4093 3701 1029 2602 M15318 GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY.html Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. 21/75 Gene Ontology BP GO:0034260 4.0840610423316e-07 2.61980478260637e-06 4170 2644.45454545455 2566 3.71278345499397e-08 565 1.31801880141879 1.04174676468559 1 8.71502287670843 4166 1332 2439 1580 565 4037 1987 3675 2566 2736 4006 2603 M11465 GO_NEURAL_RETINA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_RETINA_DEVELOPMENT.html The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. 23/87 Gene Ontology BP GO:0003407 1.41004034189557e-07 1.47591794840629e-06 2340 2594.54545454545 2567 1.2818549384263e-08 195 1.21785109892147 1.27588951654452 1 8.412219861206 2340 2194 2297 3344 195 2928 2571 4402 3280 2422 2567 2604 M12093 GO_INORGANIC_CATION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_IMPORT_INTO_CELL.html The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 10/26 Gene Ontology BP GO:0098659 0.0016362522711339 0.00238528078332016 2175 2537.63636363636 2567 0.000148860954920493 1956 1.75733049630853 -1.75733049630853 -1 5.45934283047615 2227 3262 2173 2813 3021 2567 2851 2056 1956 2815 2173 2605 M13155 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. 30/55 Gene Ontology BP GO:0034502 0.0839184282471183 0.0949861682962873 1790 2914.18181818182 2567 0.00793650793650794 1788 1.43704577870223 -1.40526690132489 -1 1.74037758794101 1788 4187 2567 4031 4149 2121 1985 1968 3629 3416 2215 2606 M15736 GO_HEXOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 87/228 Gene Ontology BP GO:0019318 0.00548877925342373 0.00751974094825801 2260 2404.81818181818 2567 0.000500229202703028 868 1.37908281223539 -1.42117789733328 -1 3.46961482328968 2259 3654 2621 3823 3369 868 2004 1154 2944 2567 1190 2607 M10459 GO_POSITIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEMOPOIESIS.html Any process that activates or increases the frequency, rate or extent of hemopoiesis. 95/254 Gene Ontology BP GO:1903708 3.28839091282906e-06 1.01651125221473e-05 3810 2311.54545454545 2568 2.98945075279395e-07 480 1.70253528500258 -1.66051564080584 -1 10.0699185570367 3810 2335 571 1695 1406 2742 3122 3080 2568 480 3618 2608 M14362 GO_GOLGI_RIBBON_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_RIBBON_FORMATION.html The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. 7/13 Gene Ontology BP GO:0090161 0.000180805150633169 0.000310687755140563 1930 2785.90909090909 2568 1.80819863044036e-05 1375 0.702881807347071 -0.702881807347071 -1 2.92065062333176 1926 2331 4228 3447 2588 1375 2568 2032 4141 4467 1542 2609 M12677 GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. 29/63 Gene Ontology BP GO:0009201 0.00937646124711319 0.0125028459420869 1160 2530.18181818182 2569 0.000856060370480243 1158 1.07497586135718 -1.18760270197291 -1 2.42333399252377 1158 3735 3229 3705 3321 1439 1504 1285 2569 3899 1988 2610 M15568 GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 48/182 Gene Ontology BP GO:0033559 1.6541845865623e-07 1.61692190219132e-06 3400 2327.18181818182 2569 1.50380428267345e-08 239 1.524332129858 1.25278080961679 1 10.4576600497282 3398 1081 1676 2569 239 2845 3534 2282 2751 2272 2952 2611 M10676 GO_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 17/35 Gene Ontology BP GO:0051125 1.31831116841865e-05 3.12132521925946e-05 3505 2686.45454545455 2570 1.19847188021083e-06 1286 1.53196650470785 -1.84781425342115 -1 8.17684552112093 3501 1493 2570 2471 1840 3961 3924 1286 2024 3460 3021 2612 M11096 GO_ALDEHYDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. 10/18 Gene Ontology BP GO:0046185 0.00195228275325855 0.00281155360526658 1800 2462.63636363636 2570 0.000177637942437949 1540 1.11527540483075 -1.02083370574347 -1 3.37038566380623 1796 2563 2604 2494 3052 2124 1540 2818 2570 2808 2720 2613 M11192 GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 36/108 Gene Ontology BP GO:0051055 1.68862953702346e-07 1.63000144291059e-06 4430 2564.36363636364 2570 1.53511787875976e-08 248 2.03047614073654 2.20740100993095 1 13.9216386358481 4426 2910 1613 2013 248 3010 4315 2371 1540 2570 3192 2614 M15509 GO_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. 145/300 Gene Ontology BP GO:0030099 6.67554550305333e-07 3.41753794909904e-06 1610 2452.27272727273 2570 6.06867957149173e-08 782 1.45942825939126 1.69440466999529 1 9.45046500572854 1609 3853 2163 2931 782 2960 1890 2145 2717 3355 2570 2615 M15235 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 12/22 Gene Ontology BP GO:0030812 0.00365950646214426 0.00510856539498972 2115 2758.63636363636 2571 0.000333237085721292 1298 0.808078511279579 0.808078511279579 1 2.19376088705953 2115 2762 2571 3703 3159 2211 1789 1298 3985 4535 2217 2616 M15324 GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 92/255 Gene Ontology BP GO:0043901 2.72180023218461e-06 8.81878470204685e-06 3260 2489.54545454545 2572 2.47436690868408e-07 1339 1.4539476458653 -1.33704923979886 -1 8.70588304339502 3257 2005 2262 2500 1339 1631 3500 2572 2936 2760 2623 2617 M11445 GO_HIPPO_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPO_SIGNALING.html The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. 13/37 Gene Ontology BP GO:0035329 0.000991255109358367 0.00148848559920792 1320 2457.45454545455 2573 9.01547292372657e-05 733 1.78458473805437 -1.78458473805437 -1 5.97695781346511 1317 4098 2573 3356 4483 756 1753 831 3965 3167 733 2618 M13590 GO_SULFUR_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSPORT.html The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/34 Gene Ontology BP GO:0072348 0.000169656841249761 0.000292505278099755 3900 2724.63636363636 2573 1.69669795191377e-05 849 1.44192664023575 -1.29235369095599 -1 6.03630617291414 3896 2415 4099 2235 2573 2804 3826 1386 849 2389 3499 2619 M13051 GO_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that modulates the frequency, rate or extent of a response to a food stimulus. 10/22 Gene Ontology BP GO:0032095 0.000278380596012053 0.000461449877645114 1500 2584.27272727273 2574 2.53105297815705e-05 1098 2.48821793095678 2.48821793095678 1 9.83277886039608 1499 3611 2482 3544 2661 1528 1098 2574 3842 3582 2006 2620 M10878 GO_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. 3/16 Gene Ontology BP GO:0006182 0.0219985613527914 0.0281375538184601 2580 2419.36363636364 2577 0.00222194161892179 1376 2.44289800522702 2.44289800522702 1 4.48760772247032 1455 3079 3650 2577 3515 1420 1376 1666 3839 2578 1458 2621 M14097 GO_VIRION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRION_ASSEMBLY.html A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. 24/47 Gene Ontology BP GO:0019068 2.02153837391321e-05 4.48019220528832e-05 870 2094.90909090909 2577 1.83777904516891e-06 87 1.03300854946378 -0.682160522974424 -1 5.32159309027244 869 2725 2577 3393 3522 87 107 2433 3286 3447 598 2622 M13378 GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION.html Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 12/24 Gene Ontology BP GO:0010935 0.000324964847306699 0.000531833551654918 2790 2424.54545454545 2578 2.95466234739656e-05 719 1.71787273353527 2.05159859539537 1 6.66311642298172 2787 2107 1440 719 2689 4013 2893 3883 1906 1655 2578 2623 M10910 GO_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROTIC_CELL_DEATH.html A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. 27/55 Gene Ontology BP GO:0070265 9.40037836179374e-05 0.00017169927904724 3470 2673 2579 8.54616368592769e-06 1682 1.29429593898342 -1.3848651891522 -1 5.77302250208377 3466 2018 2579 2342 2418 2190 3688 1682 2863 3215 2942 2624 M11247 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. 3/14 Gene Ontology BP GO:0002839 0.00866005825534631 0.0115875073428164 2495 2784.90909090909 2579 0.000869399299983247 1292 1.13086673210627 -1.13086673210627 -1 2.5935632242958 2493 3989 3716 3454 3802 1983 1658 1292 3771 2579 1897 2625 M13383 GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. 6/24 Gene Ontology BP GO:0031954 2.37930269768367e-05 5.16944427952516e-05 1720 2257.81818181818 2579 2.37932817293352e-06 286 0.884317252637581 0.884317252637581 1 4.49049847367679 1716 2801 4065 3314 2579 1393 620 286 3794 3136 1132 2626 M10359 GO_NATURAL_KILLER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. 7/15 Gene Ontology BP GO:0001779 0.000177640962889477 0.000305703109968807 4240 2815 2581 1.77655164827569e-05 915 1.27752661306802 -0.805999890095968 -1 5.31907604620311 4238 1035 3572 1616 2581 3148 2460 4610 915 2371 4419 2627 M12204 GO_CITRULLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CITRULLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 3/13 Gene Ontology BP GO:0000052 0.0100227679749826 0.0132845308900498 2890 2530.54545454545 2581 0.00100682621726939 1087 2.1095112941936 -2.1095112941936 -1 4.68968808134974 2886 2530 3869 1723 3312 3077 3096 1856 1087 2581 1819 2628 M13029 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 12/19 Gene Ontology BP GO:2001241 0.0162353838313884 0.0210796664231365 1900 2640.09090909091 2582 0.00148694991614956 1427 1.11592508079963 1.11592508079963 1 2.21575701784921 1896 2280 2881 3077 3827 2582 1679 1427 3396 3697 2299 2629 M14486 GO_RESPONSE_TO_MUSCLE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. 19/61 Gene Ontology BP GO:0014850 2.07458883062695e-07 1.84881304042245e-06 3110 2359.18181818182 2582 1.88599002387241e-08 307 1.3709742902262 -1.09667793339375 -1 9.31102261404321 3110 307 1466 1064 314 4524 4071 3428 2582 2025 3060 2630 M13049 GO_CILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 109/278 Gene Ontology BP GO:0044782 2.25502495161717e-06 7.77288853033298e-06 1695 2480.54545454545 2583 2.05002478458785e-07 1256 1.13811174618571 1.05589597123052 1 6.88865282250108 1692 1466 3144 4065 1256 1635 1380 3631 2816 3618 2583 2631 M13086 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. 118/306 Gene Ontology BP GO:1904950 5.32990447761412e-05 0.000103670773216519 2790 2595.09090909091 2583 4.84548509884467e-06 963 1.30536187622631 -1.13751660230619 -1 6.16120555792762 2786 963 1897 2209 2264 4378 2583 2721 2829 2436 3480 2632 M11094 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO.html The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. 5/18 Gene Ontology BP GO:0008595 0.000252793327320986 0.000422075196181448 3195 2362.27272727273 2584 2.52822088935749e-05 602 1.26632050859763 -1.53561774604294 -1 5.06226887996869 3193 1039 3687 1506 3853 2584 2359 602 1220 2973 2969 2633 M12094 GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 26/59 Gene Ontology BP GO:0051281 4.05579330799565e-07 2.61980478260637e-06 4320 2640.90909090909 2585 3.6870855051805e-08 562 1.41603946176066 -1.40074858128239 -1 9.36315662198933 4319 1842 1948 2585 562 3376 4445 1278 3116 1719 3860 2634 M12969 GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. 13/34 Gene Ontology BP GO:0030201 0.000196425306375207 0.000335541831309819 2005 2338.36363636364 2585 1.78584405681782e-05 889 1.64221243888177 0.635103749528551 1 6.75878782908147 2005 2923 2618 3388 2585 1300 889 2710 1428 3753 2123 2635 M14898 GO_TRIPARTITE_REGIONAL_SUBDIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIPARTITE_REGIONAL_SUBDIVISION.html Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. 5/18 Gene Ontology BP GO:0007351 0.000235596085768066 0.000396905887598379 3195 2421.27272727273 2585 2.35621066977648e-05 592 1.26632050859763 -1.53561774604294 -1 5.10232512617262 3194 1040 4312 1507 3854 2585 2360 592 1221 2999 2970 2636 M14280 GO_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_CHEMOTAXIS.html The directed movement of a lymphocyte in response to an external stimulus. 13/56 Gene Ontology BP GO:0048247 0.000333692829007402 0.000543817411400971 2160 2547.45454545455 2586 3.03403139822941e-05 1461 1.55171314162259 1.85663954376035 1 6.00084389638995 2156 3070 1678 3038 2694 2779 2586 1461 3853 2481 2226 2637 M11534 GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. 6/17 Gene Ontology BP GO:0072202 0.000505964695436099 0.00080314327552472 2845 2480.72727272727 2587 5.06079932487731e-05 342 1.92389093941513 1.49012968147419 1 7.05420607342206 2842 342 3764 1208 2793 2587 2448 3893 1099 2177 4135 2638 M12238 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 4/21 Gene Ontology BP GO:0051589 0.000179957511816724 0.000309345696914125 1955 2738.36363636364 2587 1.79972086595611e-05 1581 1.39040237939933 -1.39040237939933 -1 5.78056973060955 1953 2378 3872 1846 2587 1934 2773 4426 3994 2778 1581 2639 M12623 GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 27/98 Gene Ontology BP GO:0071384 0.0161273565742879 0.0209452633774597 1810 2636.09090909091 2587 0.00147698252423077 953 2.68834365424538 2.65186065113497 1 5.34676682878446 1807 4489 953 2587 3360 2921 3097 2695 2575 2282 2231 2640 M10312 GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE.html Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. 41/108 Gene Ontology BP GO:0035019 0.00234705411838027 0.00334788702661738 2575 2974.18181818182 2590 0.000213596527486343 2104 1.88302586215114 1.73632049593432 1 5.52140589863897 2574 4086 2104 2975 3081 3382 2268 4587 2560 2509 2590 2641 M14939 GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. 6/15 Gene Ontology BP GO:0043558 0.00109830018770765 0.00163599864341566 2595 2552.81818181818 2590 0.000109884338407378 1301 0.638034812642598 -0.616521354713752 -1 2.10589676535251 2595 1301 4321 2590 2954 1351 1917 1576 2831 4506 2139 2642 M12735 GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is divided into specific regions along the rostrocaudal axis. 10/21 Gene Ontology BP GO:0021903 1.07967460241821e-05 2.63838377843565e-05 3260 2647.63636363636 2591 9.81527182798601e-07 1504 1.0696072319834 1.34115694342605 1 5.80150798411679 3260 1504 2302 2373 1777 3650 2591 1887 4053 2821 2906 2643 M12785 GO_PEPTIDYL_THREONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_THREONINE_MODIFICATION.html The modification of peptidyl-threonine. 44/87 Gene Ontology BP GO:0018210 4.04794566356322e-05 8.12915731657613e-05 2350 2770.90909090909 2591 3.68001831516574e-06 2187 0.946459992044426 1.01659895265413 1 4.58562647956949 2349 2721 2912 3091 2187 2591 2398 2472 3576 3858 2325 2644 M13834 GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. 3/19 Gene Ontology BP GO:0060707 3.52909827652711e-05 7.20563029811581e-05 4310 2960.18181818182 2591 3.52915432318572e-06 1166 1.54155234454389 -2.31589561865601 -1 7.56450942279674 4306 1878 4141 1655 2174 4478 4053 1166 1997 2591 4123 2645 M15580 GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. 23/53 Gene Ontology BP GO:0000096 6.60192660089588e-06 1.75058510610849e-05 2450 2639 2591 6.00176946594583e-07 1254 1.42360202109702 -1.35398241359613 -1 8.02200686954889 2446 1254 2331 3099 1646 2708 1556 4562 2591 2901 3935 2646 M10260 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. 61/134 Gene Ontology BP GO:0002504 1.86103731448228e-07 1.73572332354834e-06 2490 2252.54545454545 2592 1.69185224719299e-08 278 1.2795866160593 -1.35822704807767 -1 8.7319121572264 2487 969 1808 2843 278 2767 1563 3201 2592 2714 3556 2647 M10600 GO_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. 19/41 Gene Ontology BP GO:0031063 2.00385640575255e-05 4.44524858667419e-05 2595 2416.09090909091 2592 1.82170423453413e-06 571 2.11851556806012 2.79089953052212 1 10.9221705624447 2592 4436 2058 3184 1971 2984 2600 699 571 2554 2928 2648 M13610 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. 118/249 Gene Ontology BP GO:0048872 3.88606219762644e-07 2.57804519639595e-06 3135 2378.45454545455 2592 3.53278444005227e-08 44 1.38384588117979 1.74975691748906 1 9.16172561632645 3134 44 2592 1066 526 4225 3555 2303 2008 3089 3621 2649 M13861 GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. 3/16 Gene Ontology BP GO:0002837 0.00733835351280942 0.00989888883206686 2495 2822.27272727273 2592 0.000736269988653461 1251 1.13086673210627 -1.13086673210627 -1 2.68519969029368 2494 3990 4147 3455 3803 1984 1659 1251 3772 2592 1898 2650 M13866 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. 3/14 Gene Ontology BP GO:0002836 0.00733835351280942 0.00989888883206686 2495 2823.36363636364 2593 0.000736269988653461 1252 1.13086673210627 -1.13086673210627 -1 2.68519969029368 2495 3991 4149 3456 3804 1985 1660 1252 3773 2593 1899 2651 M15120 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. 61/134 Gene Ontology BP GO:0002495 1.86103731448228e-07 1.73572332354834e-06 2490 2256.81818181818 2593 1.69185224719299e-08 279 1.2795866160593 -1.35822704807767 -1 8.7319121572264 2488 970 1809 2844 279 2768 1564 3238 2593 2715 3557 2652 M16769 GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of tight junction assembly. 13/24 Gene Ontology BP GO:2000810 9.31999061266275e-05 0.000170566481728787 2950 2475.54545454545 2593 8.47307769488796e-06 453 1.94032499988272 1.2300362494856 1 8.66115166547283 2949 3011 1617 2375 3513 2978 2593 453 1198 2493 4051 2653 M12552 GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 79/187 Gene Ontology BP GO:0042990 7.74619475902693e-06 1.99808790367567e-05 3730 2766.18181818182 2595 7.0420200304497e-07 1294 1.49381886536745 -1.31733765739037 -1 8.31604858233255 3729 1886 2521 1859 1683 2595 3801 4555 1294 3255 3250 2654 M11408 GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. 10/19 Gene Ontology BP GO:0035886 0.00118310130188374 0.00175555747671659 1890 2644 2596 0.000107612547420404 1717 1.17045951219439 1.12989626103067 1 3.82074549440205 1889 1717 2210 2596 2952 2464 3065 3530 3702 2059 2900 2655 M12145 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. 19/48 Gene Ontology BP GO:0001916 0.0839184282471183 0.0949861682962873 1980 2751.72727272727 2596 0.00793650793650794 1744 1.59727439668181 -1.32698032198317 -1 1.93442747088364 1977 3769 2458 3138 3985 1744 2022 2822 3201 2557 2596 2656 M14074 GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 166/421 Gene Ontology BP GO:0045089 1.46093660843349e-06 5.76306599231666e-06 2100 2522.81818181818 2597 1.32812507144274e-07 1085 1.32736646754249 -1.29018988922645 -1 8.23845869384753 2099 3822 2775 3906 1085 1143 1866 2597 3288 3261 1909 2657 M16192 GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of a response to tumor cell. 3/16 Gene Ontology BP GO:0002834 0.00649181701509076 0.00881846296110778 2500 2856 2598 0.000651086001651134 1221 1.13086673210627 -1.13086673210627 -1 2.75244120046686 2496 3992 4526 3457 3805 1986 1661 1221 3774 2598 1900 2658 M11500 GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 31/76 Gene Ontology BP GO:0002755 0.00027920724552023 0.000462324978940952 1645 2237.90909090909 2599 2.53856987886118e-05 1019 1.28476526257582 -1.52123966761264 -1 5.07579924456709 1642 3246 2487 2726 2662 1019 2599 1331 3220 2632 1053 2659 M11523 GO_POSITIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of STAT cascade. 35/133 Gene Ontology BP GO:1904894 4.19585767419199e-05 8.39714102641095e-05 4160 2859.63636363636 2599 3.81448881823946e-06 995 1.5626047528305 1.37497972678399 1 7.54479276391953 4159 1249 1494 1639 2195 3914 4463 4237 2599 995 4512 2660 M15621 GO_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_P38MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of p38MAPK cascade. 19/45 Gene Ontology BP GO:1900744 2.62070031313652e-05 5.60975615608066e-05 2950 2482.90909090909 2599 2.38248321105251e-06 1042 1.2962029738115 1.48329740384074 1 6.52751428583181 2947 2401 1675 2599 2039 2690 2121 3290 3304 1042 3204 2661 M13257 GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of receptor activity. 26/62 Gene Ontology BP GO:2000273 0.000211089853715967 0.000359138948627056 2370 2417.45454545455 2600 1.91918282267763e-05 961 0.897988240245875 1.01182427630962 1 3.66441526544044 2368 1480 2987 2944 2600 2784 1617 961 3417 3102 2332 2662 M13682 GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 3/19 Gene Ontology BP GO:0010919 0.00107028172711773 0.00159680883262649 2600 2345.18181818182 2600 0.000107079755314113 168 3.2192329663136 3.2192329663136 1 10.6655592325593 2600 2716 4116 1690 3016 3514 3520 857 168 2589 1011 2663 M15878 GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. 35/133 Gene Ontology BP GO:0046427 4.19585767419199e-05 8.39714102641095e-05 4160 2859.54545454545 2600 3.81448881823946e-06 997 1.5626047528305 1.37497972678399 1 7.54479276391953 4160 1250 1495 1640 2196 3915 4464 4225 2600 997 4513 2664 M16526 GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 3/17 Gene Ontology BP GO:0043950 0.0296411081608676 0.0375200832036282 2300 3028.36363636364 2600 0.00300440614452576 1249 1.65086878187987 1.65086878187987 1 2.78823627843622 2299 4264 4575 4083 4248 2016 1249 2113 4306 2600 1559 2665 M10193 GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. 25/79 Gene Ontology BP GO:0061097 2.81751565090648e-05 5.95083969983319e-05 4620 2757.36363636364 2601 2.56141066833142e-06 997 1.53596473449102 1.778420401041 1 7.68828217567877 4616 1176 2261 1320 2073 3354 4555 2789 997 2601 4589 2666 M10920 GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. 11/30 Gene Ontology BP GO:0044065 0.000214018155422683 0.000363721191664537 2605 2439 2601 1.94580889231361e-05 1354 1.40634400890863 1.24541059200418 1 5.72968752860549 2525 1354 2601 2624 2602 2434 1452 3091 2734 2227 3185 2667 M12535 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. 33/88 Gene Ontology BP GO:0032735 0.0839184282471183 0.0949861682962873 2580 2818.90909090909 2601 0.00793650793650794 1884 1.61725789544192 -1.62443727886128 -1 1.95862911253844 2578 3463 1884 3044 4180 2179 2909 2601 3300 2337 2533 2668 M12668 GO_REGULATION_OF_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of heart morphogenesis. 12/47 Gene Ontology BP GO:2000826 0.00538345421198756 0.00738634098884699 2605 2313.09090909091 2602 0.000490606633144273 1149 1.502398685157 -1.09554970056641 -1 3.7936986945742 2602 2068 2610 1465 3297 1743 2849 1149 1943 3048 2670 2669 M15238 GO_COENZYME_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 10/22 Gene Ontology BP GO:0009109 0.00113622977752812 0.00169032837457965 2845 2585.09090909091 2602 0.000103347002599949 758 1.58982311632127 1.98767436479438 1 5.22064936668997 2843 2407 2428 2029 3043 4567 3576 2602 1347 2836 758 2670 M15923 GO_CELLULAR_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. 10/14 Gene Ontology BP GO:0043482 0.000226115537401025 0.000382182176975958 1510 2107.90909090909 2602 2.05580709866383e-05 770 0.799219177150318 -0.836233174610632 -1 3.23579849037316 1507 2602 2826 2897 2616 824 1227 770 3879 2840 1199 2671 M16896 GO_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. 10/14 Gene Ontology BP GO:0043476 0.000226115537401025 0.000382182176975958 1510 2110.54545454545 2603 2.05580709866383e-05 783 0.799219177150318 -0.836233174610632 -1 3.23579849037316 1508 2603 2827 2898 2617 825 1228 783 3880 2847 1200 2672 M11248 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD.html The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). 14/61 Gene Ontology BP GO:0043153 0.000108895258692824 0.000195927959041734 3285 2545.09090909091 2604 9.90005901336278e-06 657 2.3362952554296 -1.11885123398691 -1 10.2620515137442 3285 2811 1532 2952 2454 2272 4219 2592 657 2618 2604 2673 M12005 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 45/100 Gene Ontology BP GO:0010595 1.58267950575099e-06 6.06541094703108e-06 3385 2349.09090909091 2605 1.43880058575584e-07 616 1.51712256990191 1.32464751519184 1 9.37629288573946 3381 1082 616 882 1113 3734 2910 4362 2605 682 4473 2674 M16815 GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. 25/91 Gene Ontology BP GO:0045671 2.98553688291575e-05 6.22724516953182e-05 2765 2609.63636363636 2607 2.71416127207146e-06 1487 1.44229676924751 -1.87086842996747 -1 7.18573733165425 2763 3547 2164 2968 2097 2193 3898 1487 2930 2607 2052 2675 M15521 GO_REGULATION_OF_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. 17/43 Gene Ontology BP GO:0098801 0.000102144565768021 0.000185039882505236 2610 2582.45454545455 2608 9.28630078017361e-06 848 1.89487427729271 2.04727365400098 1 8.37887157092982 2608 2700 848 2087 2439 3664 2556 4619 2636 881 3369 2676 M11418 GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. 9/21 Gene Ontology BP GO:0019359 0.00566414357361531 0.00774485050917435 2385 2716.90909090909 2609 0.000567863271252987 1653 1.07826741791341 -1.20342348181918 -1 2.69643442949549 2385 1653 3742 2609 3238 2058 2957 3760 2248 2673 2563 2677 M15097 GO_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of ions within an organism or cell. 272/819 Gene Ontology BP GO:0050801 5.13311821425706e-07 2.93634739771727e-06 2830 2313.72727272727 2609 4.66647219266804e-08 296 1.61291291881489 1.69373729778336 1 10.5702739153436 2828 1368 304 1601 668 4629 3583 3872 2609 296 3693 2678 M16063 GO_PEPTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 9/24 Gene Ontology BP GO:0043171 0.00304953392985803 0.00429190240567773 3495 2797.27272727273 2610 0.000305372687599727 1794 2.02749619764678 -2.05616607205913 -1 5.68591708305025 3494 2610 4503 2535 3147 2079 2248 3133 1794 1932 3295 2679 M16385 GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. 9/21 Gene Ontology BP GO:0019363 0.00566414357361531 0.00774485050917435 2390 2794.36363636364 2610 0.000567863271252987 1654 1.07826741791341 -1.20342348181918 -1 2.69643442949549 2386 1654 4555 2610 3239 2059 2958 3759 2249 2705 2564 2680 M11705 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 93/207 Gene Ontology BP GO:1903828 6.75169724225366e-07 3.42602516893811e-06 2615 2479.54545454545 2611 6.13790846756264e-08 793 1.20451272824286 -0.832114206170411 -1 7.7982330924341 2611 1377 2941 2679 793 3696 2316 2053 2549 3314 2946 2681 M10461 GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. 5/23 Gene Ontology BP GO:0003148 0.000565343546790867 0.000890699045724464 1560 2638 2613 5.65487424305667e-05 1557 1.05235478778515 1.05235478778515 1 3.80257889721424 1557 2613 3589 2707 2810 1735 1790 3953 3998 1959 2307 2682 M12960 GO_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 20/45 Gene Ontology BP GO:0036314 0.00806128203182392 0.0108206222820927 3275 2946.90909090909 2614 0.000735542978019384 1997 1.15406487108802 -1.30338855860047 -1 2.6874218357415 4085 2467 2510 2458 3274 2614 4224 1997 3375 2137 3275 2683 M11678 GO_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a leukocyte. 84/448 Gene Ontology BP GO:0002443 7.96291201955529e-08 1.06854914759524e-06 3390 2484.45454545455 2615 7.23901118888485e-09 74 1.36399835380078 -0.957375794457518 -1 9.64836866920055 3390 1153 2018 2093 74 3369 4111 1956 2615 2949 3601 2684 M11975 GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. 203/495 Gene Ontology BP GO:0043623 2.53883175233356e-06 8.44913067604104e-06 3415 2483.36363636364 2615 2.30803152926071e-07 1270 1.58950721680362 -1.36669816812918 -1 9.55259759678846 3413 3081 2460 1731 1306 2068 3338 2811 1270 2615 3224 2685 M14846 GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. 11/22 Gene Ontology BP GO:0032682 0.0111602835214121 0.0146898419479097 1400 2364 2615 0.00101975485478854 874 1.47139451538065 1.47139451538065 1 3.19495991615443 1397 3153 2615 3764 3789 1033 874 1467 3735 2940 1237 2686 M10592 GO_MYELOID_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. 28/60 Gene Ontology BP GO:0061515 2.48459878268347e-06 8.31123353602257e-06 1475 2740.27272727273 2617 2.25872871700186e-07 1298 1.20303936978967 1.20303936978967 1 7.24019311428066 1471 3830 2903 4019 1298 2426 2617 1626 3476 3879 2598 2687 M14429 GO_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. 72/179 Gene Ontology BP GO:0006006 0.00066285254537581 0.0010286177701136 2265 2368.36363636364 2617 6.02774858986582e-05 654 1.30144078380025 -1.29760279913656 -1 4.60623430805449 2261 3519 2617 3426 3595 693 1976 1303 3057 2951 654 2688 M13420 GO_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a protein. 447/1131 Gene Ontology BP GO:0006468 8.25817193568889e-08 1.08928103117624e-06 2700 2525.54545454545 2619 7.50742931425192e-09 82 1.35034112338913 1.42969979005615 1 9.53841329110019 2696 1959 2619 2058 82 4236 2604 3712 2736 1890 3189 2689 M15034 GO_RNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYADENYLATION.html The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. 22/35 Gene Ontology BP GO:0043631 0.000229138079767865 0.000387009132179774 1430 2446.36363636364 2620 2.08329044382684e-05 736 0.646360418766108 -0.646360418766108 -1 2.61274534137933 1430 3007 3350 3940 2620 736 765 1503 3949 4515 1095 2690 M15880 GO_LIPID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_OXIDATION.html The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. 48/91 Gene Ontology BP GO:0034440 0.00853735621767267 0.0114398109433346 3295 2882.18181818182 2621 0.000779151594518522 1919 1.30977033269875 1.37779705809019 1 3.01251040695132 3292 2621 2304 3592 3280 1919 2522 2469 3693 3611 2401 2691 M16505 GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 18/41 Gene Ontology BP GO:0043536 8.36891697616064e-05 0.000154561978998862 2625 2740.36363636364 2621 7.60839577378908e-06 1885 1.2598281286349 1.11021912694184 1 5.68743599923892 2621 3066 1946 2060 2386 2832 2421 4083 3180 1885 3664 2692 M12448 GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 12/29 Gene Ontology BP GO:0060099 0.00443530691204995 0.00614720298287998 1490 2555.54545454545 2622 0.000404024911449618 758 2.74357522225555 2.5184649869079 1 7.1869884399242 1487 3123 758 2622 3573 2681 2176 3745 3084 2349 2513 2693 M10962 GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. 10/28 Gene Ontology BP GO:0032780 5.26835904645442e-06 1.46123005093715e-05 3115 2594.45454545455 2623 4.78942878425612e-07 1287 1.25341788598787 -1.59634892195862 -1 7.1795238402283 3111 1287 2699 2503 1575 2894 4583 1732 2623 3566 1966 2694 M15230 GO_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that modulates the frequency, rate or extent of membrane invagination. 12/29 Gene Ontology BP GO:1905153 0.00443530691204995 0.00614720298287998 1490 2557.09090909091 2623 0.000404024911449618 759 2.74357522225555 2.5184649869079 1 7.1869884399242 1488 3124 759 2623 3574 2682 2177 3743 3085 2359 2514 2695 M15603 GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. 10/24 Gene Ontology BP GO:0070861 0.000931819182898009 0.00140617323770654 1545 2419.72727272727 2623 8.47467357267614e-05 607 0.806872968118646 -0.886085120351304 -1 2.72600474966934 1542 3473 2623 3468 3146 607 904 2360 4178 3593 723 2696 M14005 GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. 44/145 Gene Ontology BP GO:0050715 1.91801084474035e-05 4.29586317034705e-05 3800 2625.81818181818 2624 1.74366142418752e-06 900 1.7653671356949 -1.82687654161407 -1 9.13253267658882 3797 2624 900 2222 1954 3120 4350 2615 2951 1275 3076 2697 M13843 GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. 6/11 Gene Ontology BP GO:0002676 0.000623079966788488 0.000972750600470393 3015 2158.45454545455 2625 6.23254738650687e-05 320 2.38103153285562 -2.40337045183038 -1 8.4956754418299 3011 1218 4143 836 2835 2625 3221 1196 320 1306 3032 2698 M14221 GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is decreased. 14/46 Gene Ontology BP GO:0045776 0.0839184282471183 0.0949861682962873 1800 2508.27272727273 2625 0.00793650793650794 1440 2.19832884649922 2.19832884649922 1 2.66235327527454 1799 3121 1612 2872 3655 2745 1440 2251 3027 2625 2444 2699 M14807 GO_CARDIOLIPIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOLIPIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. 6/15 Gene Ontology BP GO:0032048 0.0127153439675787 0.0166677984306798 2190 2564.45454545455 2625 0.00127886913181606 236 2.43624335625953 -0.486308245397195 -1 5.13168658149972 2187 3987 4296 2625 3642 3269 1700 1385 236 3150 1732 2700 M13817 GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. 7/19 Gene Ontology BP GO:1900745 0.000517185025535609 0.00082011273004161 1700 2497.72727272727 2626 5.17305431134182e-05 922 1.39849905028819 1.50387305879592 1 5.11274168260872 1699 2370 4137 3567 2796 1665 1039 2999 3655 922 2626 2701 M10772 GO_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ASSEMBLY.html Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. 145/403 Gene Ontology BP GO:0030031 1.09425213699997e-06 4.67828054520338e-06 2450 2580.54545454545 2628 9.94775164788639e-08 980 1.29797511936585 1.27911747166082 1 8.19529442009813 2448 1963 2829 3684 980 2203 1859 3235 2628 3354 3203 2702 M10860 GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. 19/40 Gene Ontology BP GO:0035872 0.000688172402039608 0.00106399749006657 1940 2133.72727272727 2629 6.25807055058e-05 660 1.17557560076796 -1.09218397229323 -1 4.14030251730899 1939 2978 3009 2629 3357 872 913 1041 2994 3079 660 2703 M15067 GO_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that modulates the frequency, rate or extent of translational initiation. 42/99 Gene Ontology BP GO:0006446 0.000242091743304427 0.00040666858327151 1385 2278.90909090909 2629 2.20107625087861e-05 643 1.33746003824598 -1.14754271801178 -1 5.37224427653861 1383 3593 3278 3324 2629 643 702 2783 1582 3953 1198 2704 M13726 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. 27/48 Gene Ontology BP GO:0008625 0.000248156343233901 0.00041565292266775 4250 2925.54545454545 2634 2.25622126616464e-05 1120 1.44625020422589 -1.53735918303686 -1 5.79296830618669 4246 2398 2472 2223 2634 3360 3887 2496 1120 2747 4598 2705 M14868 GO_MAST_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a mast cell. 10/51 Gene Ontology BP GO:0002448 0.0670915521545188 0.0816101851332017 1750 2524.45454545455 2634 0.00629358550088543 999 2.34870212681379 3.20458622261604 1 3.02786652704929 1747 4102 1179 2759 4522 2634 999 1920 3020 2832 2055 2706 M15379 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. 59/148 Gene Ontology BP GO:1903426 1.02503610628169e-06 4.49016415778085e-06 3210 2534.81818181818 2635 9.31851439884055e-08 900 1.32802331518911 1.21422141915516 1 8.41305675390066 3209 1614 1775 900 949 4051 2635 4034 2765 1602 4349 2707 M15081 GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION.html Any process that activates or increases the frequency, rate or extent of dendrite extension. 7/29 Gene Ontology BP GO:1903861 0.000105308271491966 0.000190103539866717 3440 2591.36363636364 2636 1.05313262249249e-05 280 2.23288366200668 -1.68019880891323 -1 9.84248897129065 3438 3162 4345 1573 2467 2363 2636 3178 280 1509 3554 2708 M15666 GO_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_EXTENSION.html Any process that modulates the frequency, rate or extent of dendrite extension. 7/29 Gene Ontology BP GO:1903859 0.000105308271491966 0.000190103539866717 3440 2599 2637 1.05313262249249e-05 281 2.23288366200668 -1.68019880891323 -1 9.84248897129065 3439 3163 4436 1574 2468 2364 2637 3158 281 1514 3555 2709 M10120 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. 60/144 Gene Ontology BP GO:0031333 1.25289770577713e-05 2.99855878758928e-05 4390 2590.72727272727 2638 1.13900440097581e-06 968 1.57033992075869 1.30087452463005 1 8.41408062237474 4386 968 2183 1491 1815 3786 3792 2763 1244 2638 3432 2710 M14411 GO_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. 17/46 Gene Ontology BP GO:0097581 6.10213904847596e-05 0.00011673766626318 770 1995.54545454545 2638 5.5475530091392e-06 337 1.30974773260454 -1.30974773260454 -1 6.1019168176419 766 3339 2910 3401 3525 337 550 397 2638 3467 621 2711 M10834 GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that activates or increases the frequency, rate or extent of membrane invagination. 9/22 Gene Ontology BP GO:1905155 0.0331351598511136 0.0417041331495582 1095 2723.18181818182 2640 0.00336398564241379 1093 3.12105437961571 3.12105437961571 1 5.10154842578795 1093 3411 3644 2640 4125 1845 1635 2413 4081 3481 1587 2712 M12405 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY.html Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. 10/23 Gene Ontology BP GO:0035794 6.53410164853341e-06 1.73855781972153e-05 3315 2892.45454545455 2641 5.94011005017992e-07 1640 1.51273398409085 1.66368929851034 1 8.52963162289036 3311 2113 2641 2445 1640 4021 3471 4399 2128 2063 3585 2713 M14759 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 9/22 Gene Ontology BP GO:0060100 0.0331351598511136 0.0417041331495582 1095 2785.18181818182 2641 0.00336398564241379 1094 3.12105437961571 3.12105437961571 1 5.10154842578795 1094 3412 4289 2641 4126 1846 1636 2418 4082 3505 1588 2714 M16365 GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 20/62 Gene Ontology BP GO:0021680 0.000252808770316736 0.000422075196181448 4035 2322.81818181818 2642 2.29852569113702e-05 710 2.58576503710874 -1.37280133695068 -1 10.3369091855884 4035 2757 787 1142 2642 3606 4074 902 710 1575 3321 2715 M13791 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. 22/66 Gene Ontology BP GO:0002639 0.0839184282471183 0.0949861682962873 2400 2776.63636363636 2647 0.00793650793650794 1920 1.79705602778475 -1.60634592414812 -1 2.17637926837439 2396 3492 2139 2523 3668 1920 2647 3644 2537 2863 2714 2716 M14057 GO_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION.html The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. 20/73 Gene Ontology BP GO:0030101 1.85174103570875e-05 4.17969549285159e-05 3790 2641.72727272727 2647 1.68341511091403e-06 1690 1.38698820235032 -1.03005030685291 -1 7.19467808591332 3789 1695 2032 2041 1943 2748 3434 3777 1690 2647 3263 2717 M14438 GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of B cell proliferation. 13/36 Gene Ontology BP GO:0030889 0.00286255459031839 0.00404468684201104 2145 2562.63636363636 2648 0.000260571457662285 677 1.24681131217978 -1.24681131217978 -1 3.53461580962034 2142 3945 2648 3933 3698 1099 677 2034 3915 3181 917 2718 M14873 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. 20/43 Gene Ontology BP GO:0048873 0.000106138955427084 0.000191379871863283 2715 2688.63636363636 2648 9.64946149497551e-06 1097 1.13012182199832 1.23718406914268 1 4.97765415750177 2715 1097 2626 1738 2447 3176 2221 3732 3825 2648 3350 2719 M12222 GO_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JAK_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. 55/201 Gene Ontology BP GO:0046425 2.22952891844651e-05 4.89210905876519e-05 3305 2753.63636363636 2649 2.02686501209899e-06 775 1.51063866861818 1.42474800923699 1 7.71376925812792 3302 775 1988 2649 1995 4396 4064 3219 2620 1401 3881 2720 M12061 GO_GLYCEROLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. 167/425 Gene Ontology BP GO:0046486 1.72059316627015e-07 1.64715754041078e-06 4455 2526.81818181818 2650 1.56417572803241e-08 253 1.62083701782296 -1.4584599808078 -1 11.1042815613876 4454 2650 1130 2264 253 2686 4502 3280 1839 950 3787 2721 M15845 GO_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of STAT cascade. 55/201 Gene Ontology BP GO:1904892 2.22952891844651e-05 4.89210905876519e-05 3305 2751.63636363636 2650 2.02686501209899e-06 776 1.51063866861818 1.42474800923699 1 7.71376925812792 3303 776 1989 2650 1996 4397 4065 3187 2621 1402 3882 2722 M15178 GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. 20/54 Gene Ontology BP GO:0032727 2.04824352745143e-06 7.27063814828515e-06 4360 2891 2651 1.86204130400833e-07 1218 1.089669005529 -1.36168892580526 -1 6.63289038563872 4356 2593 2712 2111 1218 3909 4374 2133 2633 2651 3111 2723 M10352 GO_CELLULAR_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 12/40 Gene Ontology BP GO:0098586 0.0839184282471183 0.0949861682962873 2655 2849.90909090909 2652 0.00793650793650794 1293 1.1141759225028 -1.06039752267416 -1 1.34935594279898 3344 2201 2423 2962 4589 2651 1293 2652 3602 1643 3989 2724 M12842 GO_CILIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MORPHOGENESIS.html A process that is carried out at the cellular level and in which the structure of a cilium is organized. 122/309 Gene Ontology BP GO:0060271 7.35757337415615e-07 3.59970634101233e-06 2655 2496.09090909091 2652 6.68870530435316e-08 41 1.17439705176318 1.04972779350212 1 7.57338033823671 2652 41 3076 2664 828 2617 1844 3998 2494 3438 3805 2725 M13168 GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 133/292 Gene Ontology BP GO:0009141 0.000150908431935071 0.000263013457009961 3360 2855.45454545455 2653 1.37198894958352e-05 1588 1.10741404119987 -0.890907298019791 -1 4.69649291022992 1588 3360 3359 4029 2528 1950 2003 3245 2611 4084 2653 2726 M13210 GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. 9/17 Gene Ontology BP GO:2000303 0.000663370967443394 0.0010290328186449 2585 2707.09090909091 2654 6.63569078149889e-05 1380 1.70145331900373 -2.83367012658679 -1 6.02165987007702 2581 2820 4032 2654 2854 2473 2478 1380 2847 3496 2163 2727 M10194 GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-beta production. 36/97 Gene Ontology BP GO:0032648 4.87738445995606e-05 9.6078472836555e-05 3350 2353.18181818182 2655 4.43408417689209e-06 674 1.00383794134797 -1.11416718278762 -1 4.77731424845522 2451 2655 3031 3367 2238 917 3350 701 3151 3350 674 2728 M13708 GO_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. 301/698 Gene Ontology BP GO:0070925 1.89476878533867e-07 1.74206167729257e-06 2545 2598.09090909091 2655 1.72251722593388e-08 290 1.45291221144305 1.69471427811594 1 9.91196340049966 2544 3513 2828 3361 290 3347 2655 1805 2051 3717 2468 2729 M14563 GO_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. 396/787 Gene Ontology BP GO:0007005 7.10889017552181e-06 1.8647838052843e-05 2135 2914.09090909091 2655 6.46264831516369e-07 1566 1.31149947922667 -0.963338971569399 -1 7.34766852323665 2132 4114 3451 4471 1663 1566 2459 2913 2500 4131 2655 2730 M15385 GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 15/49 Gene Ontology BP GO:0045923 0.00175376832871285 0.00254143144513538 2655 2671.27272727273 2655 0.000159560721631981 1766 1.59837269530181 1.55667819239974 1 4.91337878424761 2655 1983 2045 1766 3033 3087 2105 3338 2392 3341 3639 2731 M10313 GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. 20/55 Gene Ontology BP GO:0031122 0.00174855990103781 0.0025354664648715 1240 2247.45454545455 2656 0.000159086473158745 468 1.19205043449448 -0.845652841097551 -1 3.66578963906062 1237 3686 2656 3121 3871 468 852 1065 3141 3669 956 2732 M14746 GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. 15/50 Gene Ontology BP GO:0046426 0.000674421949587673 0.00104447668843748 2330 2533.36363636364 2656 6.1329889643142e-05 1345 1.40467116092267 1.63005159204804 1 4.96054446562964 2329 1345 2779 2764 2829 2656 2449 2691 2078 3339 2608 2733 M15099 GO_NEGATIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STAT_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade. 15/50 Gene Ontology BP GO:1904893 0.000674421949587673 0.00104447668843748 2330 2534.18181818182 2657 6.1329889643142e-05 1346 1.40467116092267 1.63005159204804 1 4.96054446562964 2330 1346 2780 2765 2830 2657 2450 2690 2079 3340 2609 2734 M16344 GO_FOLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 11/20 Gene Ontology BP GO:0046655 0.000276172993322481 0.000458609158796953 4400 2748.45454545455 2657 2.51097880263984e-05 718 2.20139113761226 -2.59816426782652 -1 8.70630872056738 4399 2164 1925 2312 2657 3607 3626 2944 718 1549 4332 2735 M12149 GO_NEGATIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 32/67 Gene Ontology BP GO:0010507 1.08142626332661e-05 2.64127414025538e-05 1825 2492.18181818182 2658 9.83119617449034e-07 1528 1.35948992180989 1.69220475304376 1 7.37305506460986 1821 2658 2716 2840 1778 1958 1528 3621 3144 3093 2257 2736 M12817 GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. 121/342 Gene Ontology BP GO:0050714 0.000277774282048157 0.000460938524499498 3060 2551.09090909091 2658 2.52553963925387e-05 545 1.75611916920117 1.88507020192778 1 6.94071951501151 3059 2455 622 1761 2658 4381 2698 3773 2398 545 3712 2737 M15987 GO_O_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_GLYCAN_PROCESSING.html The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. 22/65 Gene Ontology BP GO:0016266 0.00374278175952894 0.00522167539347743 3740 2773.90909090909 2658 0.000340833129841975 1509 1.4134864408397 -1.36209028597659 -1 3.82139015202797 3737 1844 2171 2534 3162 3241 3945 2658 1509 2309 3403 2738 M10468 GO_CELLULAR_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 26/70 Gene Ontology BP GO:0006073 0.0839184282471183 0.0949861682962873 1425 2652.90909090909 2659 0.00793650793650794 1425 1.21892172692274 1.32768854269802 1 1.47621162777414 1425 3035 2777 3686 3843 2098 1820 2485 2987 2659 2367 2739 M13530 GO_PHAGOSOME_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_ACIDIFICATION.html Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. 16/30 Gene Ontology BP GO:0090383 0.00027807828758179 0.000461278131204805 765 2077.54545454545 2659 2.52830402438234e-05 604 1.06684285779963 -1.06684285779963 -1 4.21608403616253 765 3524 2759 3509 2659 604 612 643 3322 3428 1028 2740 M15994 GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 87/233 Gene Ontology BP GO:0043902 1.29610702110826e-06 5.31609973410392e-06 4005 2786.90909090909 2659 1.17827980426982e-07 993 1.46259007323023 -1.25090368137955 -1 9.13848645494696 4001 4027 2079 3209 1044 993 2659 4470 2958 2568 2648 2741 M11976 GO_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE.html Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. 590/1913 Gene Ontology BP GO:0006952 3.82131143133311e-07 2.57804519639595e-06 4425 2657.45454545455 2661 3.82131208844221e-08 294 1.70256272841111 -1.59166879589981 -1 11.2717848934056 4422 737 3836 1778 580 2661 4597 3985 2245 294 4097 2742 M12331 GO_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 26/70 Gene Ontology BP GO:0044042 0.0839184282471183 0.0949861682962873 1430 2653 2662 0.00793650793650794 1426 1.21892172692274 1.32768854269802 1 1.47621162777414 1426 3036 2778 3687 3844 2099 1821 2474 2988 2662 2368 2743 M16790 GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of organelle assembly. 28/66 Gene Ontology BP GO:1902117 0.000818778382952324 0.00124764950182069 910 2119.54545454545 2662 7.44621152912547e-05 832 1.1855833045726 -1.32719814368601 -1 4.07842763920264 908 2784 2662 2687 2883 832 1092 1770 2683 3685 1329 2744 M12054 GO_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_PRECURSOR_CELL_PROLIFERATION.html The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. 49/155 Gene Ontology BP GO:0061351 3.11428952431882e-06 9.75026720257066e-06 2725 2437.90909090909 2664 2.83117630261151e-07 1389 1.72870358953628 1.81454563029895 1 10.2617524912673 2721 3062 1694 2677 1389 3050 1766 3512 2288 1994 2664 2745 M16471 GO_BILE_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 18/68 Gene Ontology BP GO:0008206 7.74029325193377e-05 0.000144446067398426 3780 2972.27272727273 2664 7.03687781205074e-06 1341 1.89740009169225 -1.53649849078361 -1 8.6318013972687 3779 2664 1341 2615 2369 3186 4572 4543 2354 1884 3388 2746 M15598 GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 26/82 Gene Ontology BP GO:0050994 2.34935138689523e-05 5.11394209533734e-05 3840 2728.72727272727 2666 2.1357967960802e-06 439 1.17609045526388 0.996224367308179 1 5.97863353366688 3836 439 1834 1550 2009 3620 3983 3753 2666 1723 4603 2747 M12202 GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. 7/10 Gene Ontology BP GO:0006995 0.000402485188150404 0.000647547167466046 2500 2706.09090909091 2668 4.02558104184925e-05 1128 1.02388559036472 1.15833660702859 1 3.86764762853267 2498 2569 3868 2668 2750 2726 2483 1128 3643 3276 2158 2748 M11326 GO_DEVELOPMENTAL_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_INDUCTION.html A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). 12/39 Gene Ontology BP GO:0031128 6.82095965193735e-05 0.000128791035640281 3665 2804.18181818182 2669 6.20106467329083e-06 1379 1.77282534409169 1.26353128848902 1 8.16970421626131 3661 2669 2036 2508 2334 3190 3161 1379 2266 3041 4601 2749 M14031 GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. 7/10 Gene Ontology BP GO:0043562 0.000402485188150404 0.000647547167466046 2500 2733.18181818182 2669 4.02558104184925e-05 1102 1.02388559036472 1.15833660702859 1 3.86764762853267 2499 2570 4175 2669 2751 2727 2484 1102 3644 3285 2159 2750 M16230 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. 93/197 Gene Ontology BP GO:2001242 5.04541745823177e-06 1.41119718425121e-05 2670 2800.72727272727 2669 4.58675366298717e-07 1565 1.52088715386372 1.78798438378606 1 8.73883755063111 2669 3933 2669 3143 1565 3673 3404 2107 2250 3068 2327 2751 M11223 GO_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTATIC_PROCESS.html Any biological process involved in the maintenance of an internal steady state. 683/1868 Gene Ontology BP GO:0042592 2.57278568431572e-07 2.0560144461752e-06 2675 2338.45454545455 2671 2.57278598218095e-08 203 1.7263812693448 1.89705898806266 1 11.6304357014429 2671 355 3712 1074 413 4193 3531 4277 2017 203 3277 2752 M12724 GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of natural killer cell activation. 13/34 Gene Ontology BP GO:0032814 0.000263977454344657 0.000439300114882524 3710 2918.45454545455 2672 2.40008303868936e-05 1789 1.51699510321649 -0.980411476589494 -1 6.03315354109541 3708 3258 1789 2672 2648 2618 2300 4631 2735 1844 3900 2753 M11041 GO_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane. 83/181 Gene Ontology BP GO:0061025 6.15301065692277e-05 0.000117613950103304 2185 2949.27272727273 2673 5.59380250225467e-06 1885 1.51204403071423 -1.59963987664865 -1 7.03856747761511 2185 4081 3246 4499 2305 2017 2673 2175 3382 3994 1885 2754 M12988 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 33/84 Gene Ontology BP GO:0046364 0.00219545266533292 0.00314225854659086 1950 2534.09090909091 2673 0.000199786058718111 1388 1.30295410637642 -1.25270165400203 -1 3.86301064007646 1947 3207 2673 3627 3074 1388 1822 2426 2963 3195 1553 2755 M15793 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 10/22 Gene Ontology BP GO:0061003 0.0195140667446192 0.0250910584035633 1040 2372.09090909091 2674 0.00178993977546573 1040 1.16175470755371 1.16175470755371 1 2.20263602961715 1040 2674 2792 2680 3661 1738 1638 1486 3442 2839 2103 2756 M16401 GO_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. 9/19 Gene Ontology BP GO:0070231 0.000502282625106412 0.000797844074022946 2675 2769 2674 5.02396190760679e-05 877 0.758528106361783 0.841243626097634 1 2.78382815032851 2674 2566 4559 2302 2792 3590 2186 877 3256 3515 2142 2757 M15133 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of natural killer cell activation. 9/23 Gene Ontology BP GO:0032816 0.000331019842169789 0.000539840227325019 2395 2506.45454545455 2675 3.31069160870725e-05 847 1.32275053766843 -0.980411476589494 -1 5.12038601955896 2393 2675 4359 2074 2712 1606 847 3143 3113 1921 2728 2758 M11425 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE.html Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. 8/29 Gene Ontology BP GO:0042749 0.00486950722678075 0.00671691088946613 2060 2590 2676 0.00048802106965657 1602 1.43043929642933 1.63086872605341 1 3.68190998888456 2056 2676 3744 2378 3217 2770 1602 1843 3649 1731 2824 2759 M11727 GO_SPECIFICATION_OF_ORGAN_IDENTITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_ORGAN_IDENTITY.html The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. 4/21 Gene Ontology BP GO:0010092 0.00573488739228024 0.00783149475363445 2360 2676.54545454545 2676 0.000574974139190212 1446 2.90883983979762 2.90883983979762 1 7.25751947677251 2360 2616 3796 2676 3240 3264 2434 1446 1601 2776 3233 2760 M15718 GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of smoothened signaling. 11/42 Gene Ontology BP GO:0045880 0.00948153350802718 0.0126212041507369 600 2158.54545454545 2676 0.00086569501613302 598 1.33175052303649 1.33175052303649 1 2.99572985345883 598 3259 2676 3065 3997 968 614 1289 2888 2945 1445 2761 M16969 GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. 7/23 Gene Ontology BP GO:0031998 0.00285241152523072 0.00403158195179489 4645 2682 2677 0.000285607946638088 797 0.758479313772085 0.758479313772085 1 2.15149721967536 1569 2677 4642 3417 3135 1239 797 1839 3898 4642 1647 2762 M16185 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 6/23 Gene Ontology BP GO:0032700 0.0365466395749612 0.0457498106083971 1775 2843 2678 0.00371619765344975 872 2.02898781386349 2.02898781386349 1 3.21985208304732 1773 4640 4525 2917 4634 1969 872 2149 2678 3157 1959 2763 M11669 GO_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. 658/1788 Gene Ontology BP GO:0016192 4.4441918455346e-07 2.74343418554066e-06 2405 2603.36363636364 2679 4.4441927343227e-08 640 1.56001306995836 1.71698147212156 1 10.2781334589376 2403 1225 3786 2842 640 4064 2679 3761 2358 945 3934 2764 M16707 GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 4/13 Gene Ontology BP GO:0051533 0.00228294210229495 0.00325944040004781 2665 2592.90909090909 2679 0.00022852908200204 135 2.83367012658679 -2.83367012658679 -1 8.34791678545132 2664 2679 4608 3071 3419 2565 3336 1004 135 2801 2240 2765 M10118 GO_ACYLGLYCEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. 14/41 Gene Ontology BP GO:0055090 0.0053707098675181 0.00737321286661341 2465 2805.54545454545 2680 0.000489442363733167 2093 1.03043098891442 -1.15918684813394 -1 2.60287818364919 2465 2513 2680 3172 3219 2432 3367 2099 3585 3236 2093 2766 M16042 GO_MULTICELLULAR_ORGANISM_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_REPRODUCTION.html The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. 355/1283 Gene Ontology BP GO:0032504 1.25727257293969e-06 5.1935200677571e-06 2680 2744.90909090909 2680 1.14297571950533e-07 1034 1.57110897151983 1.67461544592918 1 9.83538526411261 2680 3651 1416 3630 1034 3444 2550 4334 2519 1993 2943 2767 M11593 GO_TRIGLYCERIDE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. 14/41 Gene Ontology BP GO:0070328 0.0053707098675181 0.00737321286661341 2470 2804.36363636364 2681 0.000489442363733167 2075 1.03043098891442 -1.15918684813394 -1 2.60287818364919 2466 2514 2681 3173 3220 2433 3368 2075 3586 3238 2094 2768 M12660 GO_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. 203/446 Gene Ontology BP GO:0097190 4.33662953170086e-07 2.70268065982377e-06 2685 2623 2681 3.94239126048677e-08 591 1.46170453793554 1.57431313455367 1 9.641683205716 2681 3139 2335 2560 591 4329 2436 2795 2527 2756 2704 2769 M14904 GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION.html A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. 334/995 Gene Ontology BP GO:0003006 4.99541907834915e-07 2.89556769973244e-06 3850 2616.18181818182 2681 4.5412911023926e-08 654 1.60809698297427 1.54328906252188 1 10.5502828259628 2654 2883 946 2681 654 3850 2987 4406 2430 1441 3846 2770 M10786 GO_VESICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. 176/377 Gene Ontology BP GO:0016050 8.47429461695576e-07 3.92711788283106e-06 2410 2520.90909090909 2682 7.70390716474111e-08 886 1.27677078273975 -1.08877278235972 -1 8.17637966887753 2410 2682 2847 3890 886 1334 2840 3199 2864 2658 2120 2771 M13793 GO_REGULATION_OF_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION.html Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. 13/63 Gene Ontology BP GO:0051931 0.209690615281109 0.230218379463275 1170 2738.72727272727 2682 0.0211664855287153 1166 1.46074551886062 1.46074551886062 1 1.10376692557109 1166 2598 1859 3316 3738 2506 1875 3119 4090 3177 2682 2772 M16918 GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN.html Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. 13/63 Gene Ontology BP GO:0051930 0.209690615281109 0.230218379463275 1170 2739.72727272727 2683 0.0211664855287153 1167 1.46074551886062 1.46074551886062 1 1.10376692557109 1167 2599 1860 3317 3739 2507 1876 3112 4091 3186 2683 2773 M16529 GO_POST_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. 47/154 Gene Ontology BP GO:0009791 3.71984524389141e-05 7.55853018266425e-05 2975 2754.27272727273 2684 3.38173467451367e-06 2161 1.30946200274473 1.40856009794657 1 6.39341350110492 2975 2623 2287 2546 2161 3523 2927 2972 2684 2565 3034 2774 M10232 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. 16/23 Gene Ontology BP GO:0070230 0.000321757808579287 0.000527328452253312 4070 2879.63636363636 2687 2.9254988767135e-05 495 2.23463354761688 -1.94757158737775 -1 8.67725823740374 4066 2025 1441 2147 2687 4504 3215 4620 495 2250 4226 2775 M10362 GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. 93/198 Gene Ontology BP GO:0032434 7.29044482833685e-06 1.9037983879622e-05 2690 2643.72727272727 2687 6.62769907982374e-07 810 1.13813937689225 -1.17634812408544 -1 6.36429511453183 2687 3934 3206 4304 1668 1041 2444 1769 3213 4005 810 2776 M10108 GO_MULTICELLULAR_ORGANISM_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_AGING.html An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). 16/39 Gene Ontology BP GO:0010259 3.6357699409243e-05 7.40064876620409e-05 2690 2467.90909090909 2688 3.30530002533991e-06 684 1.92541764558658 2.46791443765816 1 9.42171151332986 2688 2840 1589 3169 2153 3616 3224 2239 684 2249 2696 2777 M12011 GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION.html Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. 7/24 Gene Ontology BP GO:0071675 4.99845034257157e-05 9.81445482343672e-05 2690 2513.18181818182 2689 4.99856277640711e-06 579 2.05560737553328 1.86336669532632 1 9.76023797961625 2689 1033 3841 1092 2276 3731 3799 4585 721 579 3299 2778 M13368 GO_GRANULOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_MIGRATION.html The movement of a granulocyte within or between different tissues and organs of the body. 33/100 Gene Ontology BP GO:0097530 0.000460287010635921 0.000734150666569077 2920 2802.72727272727 2689 4.18530309755816e-05 1550 1.92471962759995 2.31421903783923 1 7.1461846212064 2917 2689 1550 2541 2758 4409 4594 2838 2074 1952 2508 2779 M12516 GO_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_PROLIFERATION.html The expansion of a leukocyte population by cell division. 38/127 Gene Ontology BP GO:0070661 1.30714754400429e-06 5.32681605067737e-06 3805 2667.36363636364 2690 1.1883166551428e-07 1047 1.47338740822927 -1.49965975030264 -1 9.20442337609968 3804 3206 2401 2690 1047 2623 3381 2416 2188 2717 2868 2780 M14664 GO_CELLULAR_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 46/139 Gene Ontology BP GO:1901655 0.0278024637688914 0.0352889117766438 1305 2891.09090909091 2690 0.00256001470402405 1305 1.40713620009818 1.21161058611326 1 2.42096624218271 1305 4184 1724 3784 3431 2269 2155 2523 3970 3767 2690 2781 M10149 GO_LABYRINTHINE_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_DEVELOPMENT.html The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. 25/64 Gene Ontology BP GO:0060711 3.02214639960102e-06 9.54545968254934e-06 3720 2615 2694 2.74740959194573e-07 893 1.5375889503437 -2.28257378129952 -1 9.14407044603579 3719 2694 2157 2377 1379 3165 4054 893 1992 3531 2804 2782 M10303 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. 87/145 Gene Ontology BP GO:0043624 0.00411105355595186 0.00570802083142478 950 2658.27272727273 2695 0.000374432352543779 950 1.27835168984631 -0.957024290404525 -1 3.39748155604882 950 3060 3369 3011 3178 1740 2033 2548 2608 4049 2695 2783 M16092 GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 20/47 Gene Ontology BP GO:0009069 0.000359369233508734 0.000582391396572793 2695 2738.36363636364 2695 3.26752681614595e-05 1731 1.14042340222008 -1.11748770110197 -1 4.37008095687819 2695 3178 2632 3019 2708 2348 3706 1731 2571 3210 2324 2784 M12436 GO_GLYCOGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. 11/33 Gene Ontology BP GO:0005978 0.0010898606686737 0.00162446969009694 2605 2804.27272727273 2696 9.91273591655432e-05 2201 1.38242530060387 1.35126164400649 1 4.56786262139545 2604 3184 2556 2633 2941 3575 2696 2922 2201 2232 3303 2785 M15212 GO_MEMBRANE_PROTEIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. 24/63 Gene Ontology BP GO:0033619 0.000405698429617479 0.000652010318004138 4250 2819.09090909091 2697 3.68884784660987e-05 486 1.96357070347154 -1.28905802843143 -1 7.41029725487064 4250 2431 1755 2399 2734 2697 3741 3713 486 2504 4300 2786 M15244 GO_GLUCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. 11/33 Gene Ontology BP GO:0009250 0.0010898606686737 0.00162446969009694 2605 2806.72727272727 2697 9.91273591655432e-05 2202 1.38242530060387 1.35126164400649 1 4.56786262139545 2605 3185 2557 2634 2942 3576 2697 2929 2202 2243 3304 2787 M13315 GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. 9/20 Gene Ontology BP GO:0035358 2.14684726258451e-06 7.55709768019703e-06 2700 2684.72727272727 2698 2.14684933661625e-07 1284 2.53262973936924 2.20204676257843 1 15.3659432885591 2698 2480 4050 2776 1284 2954 3026 4144 2640 1915 1565 2788 M15554 GO_RENAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_ABSORPTION.html A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). 9/35 Gene Ontology BP GO:0070293 0.01964935619966 0.0252580179498952 2285 2846 2698 0.00198252933908263 2137 3.16769494788899 -2.58373837981968 -1 5.9950054570155 2285 2800 4421 2317 3400 2313 2803 3873 2137 2698 2259 2789 M14640 GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosyl compound. 194/462 Gene Ontology BP GO:1901657 0.000162441580532565 0.000280899910023352 1615 2817.36363636364 2700 1.47685069077171e-05 1611 1.19817174384164 -0.990211153186773 -1 5.0408356651095 1611 3901 3316 3665 2553 1823 1994 2874 2700 4071 2483 2790 M13124 GO_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that modulates the frequency, rate, or extent of mast cell activation. 25/56 Gene Ontology BP GO:0033003 0.000350793274560934 0.000570284724715131 2915 2699.36363636364 2701 3.18953837782054e-05 1387 1.39557795512752 -1.35902612002835 -1 5.36291149490423 2912 3115 2467 3303 2701 1387 2663 2916 3271 2603 2355 2791 M16044 GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 9/17 Gene Ontology BP GO:0060547 0.0231276703302754 0.0295329409635502 2375 2655.90909090909 2701 0.00233719563054785 777 1.25302403505962 -1.15082268762976 -1 2.27060477506653 2375 3076 4499 3182 3567 1822 777 2326 3415 2701 1475 2792 M10586 GO_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING.html A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. 15/30 Gene Ontology BP GO:0016233 0.00320476012300516 0.00449266342122976 505 2166.18181818182 2702 0.000291767097213088 501 1.05518540161294 -1.05518540161294 -1 2.93434726702402 501 2702 2853 3033 3416 543 661 1593 3849 3330 1347 2793 M10798 GO_ENDOCARDIAL_CUSHION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_DEVELOPMENT.html The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 17/53 Gene Ontology BP GO:0003197 6.10467496451905e-05 0.000116738080149349 4045 2964 2702 5.54985851528275e-06 1483 1.70562196441593 -1.12347680432071 -1 7.94623245463342 4045 1935 1483 2052 2303 3802 3865 4465 2702 2320 3632 2794 M12704 GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 20/39 Gene Ontology BP GO:0042558 0.000119837713074466 0.000213862458923967 3820 2828.09090909091 2702 1.0894931030437e-05 1385 1.55807978630496 -1.6402375031298 -1 6.77357319662268 3817 2270 2469 2702 2471 3132 3482 2773 1385 2641 3967 2795 M16127 GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 9/20 Gene Ontology BP GO:0009226 0.000999299494212146 0.0014995952009137 1495 2328.54545454545 2702 9.9974914858545e-05 927 1.12339475953204 -1.12339475953204 -1 3.75819218682441 1491 2868 4514 3026 2944 1131 1669 1099 3243 2702 927 2796 M16296 GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. 9/35 Gene Ontology BP GO:0032925 0.0237442313305798 0.0302869412274402 2005 2854.09090909091 2704 0.00240018182996431 1201 1.26944557754856 1.26944557754856 1 2.28389751183772 2001 3778 4543 3541 3806 2279 1201 2004 4049 2704 1489 2797 M12858 GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 10/38 Gene Ontology BP GO:0051354 0.000533197247383283 0.000844638287137695 3480 2651.90909090909 2705 4.84842289276902e-05 1317 1.87987729935165 -2.10494645862912 -1 6.84410377259016 3476 2705 1653 2583 2778 3777 2719 2376 1317 2065 3722 2798 M12015 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. 22/44 Gene Ontology BP GO:0002832 0.0135527047806191 0.01770048053345 3225 2634.09090909091 2706 0.00123972009123102 1404 1.48786029543486 -1.1996131583203 -1 3.08800379682676 3222 2632 2706 2472 3333 1692 2999 2797 1404 3319 2399 2799 M16580 GO_BONE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. 9/37 Gene Ontology BP GO:0070977 0.00215778354856301 0.00309024954225109 1145 2516.18181818182 2706 0.000215988162978982 994 1.74757423268636 1.74757423268636 1 5.19623077896471 1143 3020 4585 3704 4300 1050 1115 994 3782 2706 1279 2800 M13392 GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. 8/14 Gene Ontology BP GO:2000052 0.00481840611359077 0.0066503744308567 3340 2623.36363636364 2707 0.00048288857749501 448 1.64816519346564 1.70443891717698 1 4.25077187484193 3337 1659 4067 887 3215 4130 2191 4471 448 1745 2707 2801 M15419 GO_HYDROGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_TRANSPORT.html The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 63/157 Gene Ontology BP GO:0006818 0.00035921697839798 0.000582347915747842 1515 2246.63636363636 2707 3.26614222651943e-05 741 1.14405706892615 -0.931490101495042 -1 4.38404904945156 1515 2946 3259 3207 2707 741 1195 1178 2952 3794 1219 2802 M14062 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 31/74 Gene Ontology BP GO:0010524 1.05564438831559e-07 1.27201868213151e-06 1855 2572.72727272727 2708 9.59676762699516e-09 126 1.41992148078343 -1.40351621821072 -1 9.91661563864159 3645 1398 1851 2708 126 4470 3308 1855 3094 1335 4510 2803 M10587 GO_PROSTATE_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a prostate gland are generated and organized. 10/37 Gene Ontology BP GO:0060512 0.000254537675205041 0.000424656279546174 3685 2522.18181818182 2709 2.31424663378358e-05 142 2.51948716999247 -1.7527656154046 -1 10.0640528757391 3684 3097 1342 1854 2644 3728 2709 3564 142 1364 3616 2804 M15852 GO_POSITIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AUTOPHAGY.html Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 56/126 Gene Ontology BP GO:0010508 3.18203365052291e-05 6.57214512427841e-05 2710 2445.81818181818 2709 2.89279970519929e-06 538 0.988248329339559 -0.907007431863254 -1 4.89619246619512 2709 538 2909 1974 2120 1544 2771 3335 3067 3353 2584 2805 M11103 GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 207/577 Gene Ontology BP GO:0019221 4.95456675768165e-06 1.39081338911221e-05 4455 2943.90909090909 2710 4.5041617416152e-07 1559 1.53631890045643 -1.42726929408564 -1 8.83900652720147 4452 2296 1899 2710 1559 2577 3618 4318 3021 2046 3887 2806 M12209 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 14/30 Gene Ontology BP GO:0010523 4.01674615967913e-05 8.07750213939516e-05 2785 2620 2710 3.65165409004769e-06 1551 1.18330745583238 -0.80830159063055 -1 5.73704053954392 2783 1641 1551 1916 2185 3551 3560 2908 3392 2623 2710 2807 M12284 GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. 8/25 Gene Ontology BP GO:1901798 0.0415007500976819 0.0516174612117699 2045 2728.09090909091 2710 0.00422967950921021 1811 1.19750781084152 1.57436404748932 1 1.82601029271119 2043 1990 3883 3061 3512 2597 1811 2250 2710 3380 2772 2808 M12980 GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a symbiont organism effects a change in the structure or processes of its host organism. 32/81 Gene Ontology BP GO:0044003 0.000147825496882013 0.000258124776992549 2120 2655.81818181818 2710 1.34395846104896e-05 1730 1.93627737435249 2.31462118979198 1 8.23035620272468 2119 3997 1730 3359 2523 2968 2985 2775 2141 2710 1907 2809 M14696 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. 18/33 Gene Ontology BP GO:0034723 0.379543247011675 0.406979052165175 970 2926.81818181818 2710 0.0424629385143443 966 1.05518540161294 -1.05518540161294 -1 0.488029722891425 966 3341 2590 3760 3913 2174 2710 2535 3951 3550 2705 2810 M10976 GO_ERYTHROCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_HOMEOSTASIS.html Any process of regulating the production and elimination of erythrocytes within an organism. 60/106 Gene Ontology BP GO:0034101 6.542131301512e-07 3.36752944932597e-06 775 2447 2711 5.94739386085802e-08 774 1.37557446331334 1.64176546056101 1 8.91790540959531 2865 774 2711 1265 775 4515 3379 2516 1831 3253 3033 2811 M15799 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. 18/33 Gene Ontology BP GO:0006335 0.380350865486118 0.40775088165598 970 2928 2711 0.0425763128428712 967 1.05518540161294 -1.05518540161294 -1 0.487001164366007 967 3342 2591 3761 3914 2175 2711 2537 3952 3552 2706 2812 M11453 GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 6/15 Gene Ontology BP GO:0060456 0.000133765632817788 0.000236239571385694 1235 2101.72727272727 2712 1.33773685460037e-05 236 3.13018124008977 3.13018124008977 1 13.4478501029029 1235 2712 3749 2752 4096 829 236 513 2913 3116 968 2813 M11972 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. 55/145 Gene Ontology BP GO:0002718 0.0175923132220539 0.0227587378907764 2800 2553 2712 0.00161223505329078 1507 1.767117171613 -1.49107495618265 -1 3.43907487354627 2800 3706 1507 2113 3370 1548 2838 3304 2712 1670 2515 2814 M10897 GO_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 26/54 Gene Ontology BP GO:0090311 0.000156890060919589 0.000272212463695685 3140 2729.72727272727 2713 1.42637500401687e-05 903 1.65449456761177 -1.03047113703607 -1 6.98737551259379 3139 3576 2241 2963 2543 3481 2713 1993 903 2661 3814 2815 M13727 GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 48/103 Gene Ontology BP GO:0042451 0.000366971990694064 0.000593676290171617 1670 2657.54545454545 2714 3.33666561746319e-05 1492 1.18459569296316 -1.01145520066311 -1 4.52765230751689 1666 3625 3302 3236 2714 1492 1814 2994 2102 3792 2496 2816 M16242 GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 48/103 Gene Ontology BP GO:0046129 0.000366971990694064 0.000593676290171617 1670 2657.27272727273 2715 3.33666561746319e-05 1493 1.18459569296316 -1.01145520066311 -1 4.52765230751689 1667 3626 3303 3237 2715 1493 1815 2981 2103 3793 2497 2817 M12167 GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 83/200 Gene Ontology BP GO:0002221 2.69883037191576e-05 5.74274492062551e-05 3415 2761.09090909091 2718 2.45351225467743e-06 2053 1.32991145588696 -1.34034263549341 -1 6.68123506487457 3414 2718 2179 2760 2053 2547 3374 3348 3054 2415 2510 2818 M14907 GO_PROTEIN_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPHOSPHORYLATION.html The process of removing one or more phosphoric residues from a protein. 94/224 Gene Ontology BP GO:0006470 1.36497784393503e-07 1.45171845804284e-06 2560 2449.27272727273 2719 1.24088902602212e-08 186 1.4039708329187 -1.04370359506863 -1 9.70977018641895 2557 2537 2719 3202 186 3501 1546 2866 1917 2883 3028 2819 M10719 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. 7/15 Gene Ontology BP GO:0002583 0.00034838906459303 0.000566574580352167 3235 2396.90909090909 2720 3.48443695370647e-05 241 2.20187472662164 -1.70349100558448 -1 8.4687346117566 3231 1362 3625 1212 2720 2763 2595 3990 241 1495 3132 2820 M12579 GO_MAINTENANCE_OF_LOCATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION_IN_CELL.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. 59/136 Gene Ontology BP GO:0051651 1.84666100832205e-07 1.735637057012e-06 3015 2485.36363636364 2720 1.67878287575382e-08 271 1.38786097273134 1.58043219491253 1 9.47081310498649 3014 2577 2720 1803 271 4483 2733 1636 2402 2887 2813 2821 M14111 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein. 20/58 Gene Ontology BP GO:0042517 0.0003861129421373 0.000623555614032517 3975 2645.09090909091 2721 3.51073385350168e-05 831 1.57400584473947 1.54943304062513 1 5.97625700264982 3975 1634 1778 2632 2721 2520 2903 4372 2727 831 3003 2822 M13147 GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING.html Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. 4/19 Gene Ontology BP GO:0010738 0.000865802007089785 0.00131498813180172 1900 2317.81818181818 2722 8.6613951807765e-05 286 1.85218955022902 1.85218955022902 1 6.32147547100536 1899 4141 4021 2722 3351 1766 606 3190 286 2787 727 2823 M14571 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 38/72 Gene Ontology BP GO:0051881 0.000660956289454617 0.00102601807152718 2735 2678.18181818182 2722 6.01049952005579e-05 1891 1.54287070350839 1.78697042646541 1 5.46274454996988 2734 2722 2534 2601 2823 3082 1891 3706 2045 3075 2247 2824 M10750 GO_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION.html A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 33/59 Gene Ontology BP GO:0006635 0.00734092001541793 0.0098994747695572 2150 2676.18181818182 2723 0.000669593646075928 1272 1.04431515063718 -0.7197172232007 -1 2.47965434897595 2149 2723 3001 3702 3268 1272 1676 2183 3787 3802 1875 2825 M16928 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 844/2274 Gene Ontology BP GO:0006357 1.71163503742358e-07 1.64536676578834e-06 2235 2794.45454545455 2723 1.71163516925984e-08 285 1.49390422734231 1.62823639009201 1 10.2355066272125 2232 3270 4638 3725 285 3834 2723 2741 2511 2573 2207 2826 M10683 GO_AMIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSPORT.html The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 47/124 Gene Ontology BP GO:0042886 4.91058479364865e-06 1.38180879981277e-05 3370 2580.09090909091 2724 4.46417795865512e-07 770 1.95944294255195 -1.82472453040311 -1 11.2799427744895 3369 2778 770 3726 1554 2724 3592 2235 2596 1835 3202 2827 M11014 GO_ENDOSOME_TO_LYSOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_TO_LYSOSOME_TRANSPORT.html The directed movement of substances from endosomes to lysosomes. 27/55 Gene Ontology BP GO:0008333 0.000913362891326516 0.00138134980600294 1780 2641.81818181818 2724 8.30674825575709e-05 1467 0.978262906513882 -0.991076325571888 -1 3.31400672609455 1780 2724 3209 3212 2908 1535 1467 2714 3479 3862 2170 2828 M11446 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 22/63 Gene Ontology BP GO:0010719 4.82371382894552e-06 1.36314688422362e-05 4295 2832.45454545455 2724 4.3852040049449e-07 1546 1.13876948275543 0.907930389116572 1 6.56353008245189 4294 2399 2456 2299 1546 3651 3343 2425 2724 2860 3160 2829 M11524 GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 9/20 Gene Ontology BP GO:0019370 0.0765897756730953 0.0916038970762961 2730 2963.81818181818 2728 0.00793650793650794 2223 1.31278639050323 1.31278639050323 1 1.61437740290381 2728 2326 3761 2496 3818 3683 3181 2681 3031 2674 2223 2830 M10951 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html The directed movement of a protein to a specific location. 792/1849 Gene Ontology BP GO:0045184 6.57462353691953e-06 1.74466757001078e-05 2595 2760.54545454545 2729 6.57464298855411e-07 463 1.33116720265088 -1.15715114189152 -1 7.50345487353428 2594 4075 3662 4132 1665 463 2729 2928 2699 4063 1356 2831 M14542 GO_ICOSANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. 39/162 Gene Ontology BP GO:0006690 2.55471860642096e-06 8.46649428237867e-06 3870 2595.27272727273 2729 2.32247415732392e-07 1204 1.71203919288084 1.29915954657881 1 10.2871803842492 3868 1895 1204 2890 1310 3341 4036 2427 2729 1581 3267 2832 M13725 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 14/61 Gene Ontology BP GO:0071380 0.0106347554455071 0.01404927478791 1355 2552.18181818182 2730 0.000971501296363944 1351 1.02357126628937 1.02357126628937 1 2.24604263568841 1351 2794 1761 2922 3307 1747 1847 2730 4158 3780 1677 2833 M16181 GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acid derivative. 39/162 Gene Ontology BP GO:1901568 2.55471860642096e-06 8.46649428237867e-06 3870 2594.18181818182 2730 2.32247415732392e-07 1205 1.71203919288084 1.29915954657881 1 10.2871803842492 3869 1896 1205 2891 1311 3342 4037 2405 2730 1582 3268 2834 M12821 GO_REGULATION_OF_STEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of steroid hormone secretion. 7/30 Gene Ontology BP GO:2000831 0.00120062843630314 0.00178042728513429 3140 2605.90909090909 2731 0.000120127760887596 874 2.01945862956787 -2.01945862956787 -1 6.57753013227703 2511 3077 3965 2763 3136 2152 3137 874 2731 2381 1938 2835 M12133 GO_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of vacuolar transport. 21/40 Gene Ontology BP GO:1903335 0.0839184282471183 0.0949861682962873 2170 2687.54545454545 2733 0.00793650793650794 1322 1.38122499709304 1.47012214395059 1 1.67277408318874 2166 3286 2830 2343 4322 2283 1322 3325 2996 2733 1957 2836 M13444 GO_MALE_MEIOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. 18/155 Gene Ontology BP GO:0007140 0.195887929044278 0.215881237729072 1975 3186.18181818182 2733 0.0196245745028042 1657 0.732024623125649 -0.517174830436356 -1 0.577346580999712 1975 4246 2733 4184 3927 1657 2067 2550 4609 4411 2689 2837 M13477 GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of osteoblast proliferation. 23/49 Gene Ontology BP GO:0033688 1.30343315623805e-05 3.0955704063495e-05 2400 2668.63636363636 2734 1.18494625340684e-06 1834 1.38542829514041 -1.28257237320722 -1 7.40060572126258 2400 3210 2449 2734 1834 2864 2308 3229 3044 2899 2384 2838 M10058 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 24/48 Gene Ontology BP GO:0042992 1.03355824379402e-05 2.54849226018886e-05 4195 2695.18181818182 2735 9.39602817703939e-07 859 1.31652247675988 -0.766593091790673 -1 7.16424590774904 4193 1689 2430 1844 1764 4209 3039 2735 859 2960 3925 2839 M12603 GO_RESPONSE_TO_PROSTAGLANDIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 26/107 Gene Ontology BP GO:0034694 0.0185610040625393 0.0239252476019906 1685 2807.81818181818 2735 0.001701770444437 1184 1.59112854292864 1.46832238779418 1 3.05565701112001 1684 3247 1184 2729 3378 2735 2432 3557 3896 3602 2442 2840 M12737 GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS.html Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. 14/57 Gene Ontology BP GO:0036473 0.0132063165735227 0.0172675099551862 2035 2699.63636363636 2735 0.00120784228107055 1153 1.15136372735323 -0.952690895492165 -1 2.40428563789223 2033 3775 2408 3499 4071 1153 2735 1514 3981 3242 1285 2841 M14055 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 21/31 Gene Ontology BP GO:2001267 3.74851884849459e-05 7.61013249390485e-05 4015 3033.63636363636 2735 3.4078024727172e-06 1848 1.42288055693203 1.4753196160647 1 6.94219609844373 4012 1848 2303 1931 2163 3923 2966 4571 2466 2735 4452 2842 M12876 GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-8 production. 44/109 Gene Ontology BP GO:0032677 8.72638176740867e-06 2.20318600033053e-05 3180 2507.63636363636 2736 7.93310580101681e-07 1688 1.30742542574231 -1.52433960829317 -1 7.21267549849866 3179 2833 2127 2736 1718 1915 3166 1688 3316 3069 1837 2843 M14499 GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 70/172 Gene Ontology BP GO:0044262 1.34167301664513e-05 3.16855941825195e-05 3350 2905.36363636364 2736 1.21971018084207e-06 1845 1.36573748928367 -1.13532363395188 -1 7.27904761771913 3347 2337 2429 3338 1845 4024 2736 3024 2080 2571 4228 2844 M14903 GO_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_SLEEP.html Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. 7/36 Gene Ontology BP GO:0030431 0.00127429589973198 0.00188605542316085 2985 2304.54545454545 2737 0.000127502721352878 138 1.91931607791573 1.91931607791573 1 6.19444808683712 2212 2737 4313 1751 2984 2985 2786 1354 138 3294 796 2845 M16164 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. 21/60 Gene Ontology BP GO:0002717 0.0515478987042622 0.0634341091131432 2340 2796.63636363636 2737 0.00479971621753914 1465 1.58475311887258 -1.02345924816165 -1 2.24842889440081 2022 3468 2006 3640 3526 1465 2338 3850 3371 2737 2340 2846 M16182 GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-alpha production. 21/57 Gene Ontology BP GO:0032647 2.16828843103821e-06 7.59752263029601e-06 4600 2993 2738 1.97117324370466e-07 1233 1.089669005529 -1.36168892580526 -1 6.60823600761383 4596 2726 2790 2112 1233 4359 4239 2109 2642 2738 3379 2847 M14059 GO_NEGATIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BINDING.html Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 84/229 Gene Ontology BP GO:0051100 0.00293571330028945 0.00414175534890425 1350 2455.18181818182 2739 0.00026723982679462 1031 1.60805985299735 1.94060584608873 1 4.53910863907142 1349 3679 2146 3006 3222 2917 2348 1031 2739 2950 1620 2848 M12782 GO_PHOSPHOLIPID_SCRAMBLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_SCRAMBLING.html The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). 8/21 Gene Ontology BP GO:0017121 0.000158992997777305 0.000275346694770617 3415 2683.54545454545 2740 1.59004374370898e-05 536 1.90579092632503 -2.28891561307478 -1 8.0374432348553 3415 2242 3958 3243 3116 2583 3292 536 2652 1742 2740 2849 M14292 GO_NEUTRAL_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. 40/116 Gene Ontology BP GO:0006638 9.98372038014574e-07 4.40631309173162e-06 4330 2671.72727272727 2741 9.07611355528689e-08 944 1.82872697190329 -1.74367532973392 -1 11.6027615565449 4326 1683 951 2741 944 3700 4214 3170 2153 1030 4477 2850 M15083 GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 28/59 Gene Ontology BP GO:0051784 0.0839184282471183 0.0949861682962873 1265 2817.72727272727 2741 0.00793650793650794 1263 1.6833717259851 1.81194555295129 1 2.03869833637352 1263 3793 2144 2965 4339 2694 3017 2553 1807 3679 2741 2851 M12757 GO_PHAGOSOME_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_MATURATION.html A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. 29/49 Gene Ontology BP GO:0090382 1.06272602759674e-05 2.60643332687584e-05 2430 2661.90909090909 2742 9.66119237460866e-07 1765 1.09363719761127 -0.990554459311279 -1 5.93870078167403 2426 3147 2742 3852 1773 1765 3141 2187 3327 2891 2030 2852 M14317 GO_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. 301/765 Gene Ontology BP GO:0005975 9.73377937647924e-07 4.31239863024743e-06 3915 2704.18181818182 2742 8.84889425739929e-08 939 1.43400154578817 -1.29662732443633 -1 9.11423289123877 3912 2850 2606 3552 939 1558 3675 2892 2323 2742 2697 2853 M12476 GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. 7/12 Gene Ontology BP GO:0006677 0.00176619511505352 0.00255704518839835 1995 2751.81818181818 2743 0.000176760043762137 1324 0.974324178434709 -0.92791957601074 -1 2.99199017844419 1991 2568 3916 3795 3050 2000 2791 1324 3713 2379 2743 2854 M15949 GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN.html The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. 4/16 Gene Ontology BP GO:0002016 0.000394167850243578 0.000635900392175445 2860 2260.27272727273 2743 3.9423778343468e-05 510 1.57196454463454 -1.57196454463454 -1 5.9526521161535 2856 1133 4485 1836 2743 3020 2941 789 510 2798 1752 2855 M11870 GO_GABAERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABAERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. 4/21 Gene Ontology BP GO:0097154 0.0211054017474537 0.0270547709313715 2665 2740.81818181818 2744 0.00213085698510814 1520 1.69379145427173 -1.69379145427173 -1 3.14569286196716 2661 2744 3819 2295 3530 2224 2960 1520 3996 2777 1623 2856 M16581 GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 76/177 Gene Ontology BP GO:0034614 0.000436357194410787 0.000698863902604099 1660 2392.18181818182 2744 3.96767061237341e-05 1206 1.49511330665327 1.77557592207441 1 5.58901200319675 1657 2805 1713 2114 2744 3261 2807 1206 3040 2882 2085 2857 M10273 GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON.html A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. 17/38 Gene Ontology BP GO:0044380 0.000441456445022086 0.000706543355476576 1080 2303 2747 4.01404594052525e-05 532 0.836081251269116 -0.836081251269116 -1 3.12072587845604 1079 3010 3029 3746 2747 532 1304 1001 3954 4193 738 2858 M12406 GO_COMPLEMENT_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION.html Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 16/240 Gene Ontology BP GO:0006956 0.000442254870458936 0.000707548745018515 3250 3016.63636363636 2748 4.02130727042766e-05 1174 1.5066785307224 1.42698322101909 1 5.6226715446515 3247 1981 1174 2700 2748 4307 4571 2626 3534 2255 4040 2859 M14467 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 27/39 Gene Ontology BP GO:1902229 4.1576528672731e-05 8.33303690994843e-05 2730 2755 2749 3.77975585675542e-06 2193 1.76577005764262 1.54442565084256 1 8.53270657536887 2730 3283 2398 2876 2193 3109 3465 2881 2279 2749 2342 2860 M16470 GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 20/42 Gene Ontology BP GO:0090314 0.000110629742528897 0.000198551949965856 2365 2665.27272727273 2749 1.00577550977358e-05 1512 0.913985878316721 0.906947830984078 1 4.00837719293141 2363 2504 2848 2870 2460 2749 1512 2509 3330 3211 2962 2861 M12472 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of smooth muscle cell proliferation. 46/99 Gene Ontology BP GO:0048661 3.1725982579311e-07 2.31342589002963e-06 2505 2457 2750 2.88418065040768e-08 453 1.75360372696951 1.81885995694198 1 11.7074089233265 2502 2750 1022 1343 453 3857 3435 4039 2801 1784 3041 2862 M13385 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of activation. 163/554 Gene Ontology BP GO:0050867 4.65618505416687e-06 1.32548542038607e-05 4390 2604.81818181818 2750 4.23290446251678e-07 754 1.47275569255384 -1.24308731822555 -1 8.50975659019665 4389 1673 1096 1297 1534 2991 4346 3824 2750 754 3999 2863 M11784 GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 80/213 Gene Ontology BP GO:0032869 1.59269147850225e-06 6.0863099050913e-06 3805 3030.45454545455 2751 1.44790239230317e-07 1118 1.33317549844705 -1.3305573478573 -1 8.23708292657776 4048 2302 2205 1885 1118 3803 3804 4317 2722 2751 4380 2864 M10227 GO_POSITIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA replication. 39/115 Gene Ontology BP GO:0045740 0.0448707697449461 0.0556004760944181 2670 2896.81818181818 2752 0.00416481464146909 1092 1.47754125851046 -1.45257213650489 -1 2.19651383141807 2668 4058 2305 3836 4446 1092 1355 4217 3364 2752 1772 2865 M10537 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 15/23 Gene Ontology BP GO:1902254 2.93612419298081e-05 6.14626899369247e-05 4095 2854.09090909091 2752 2.66923943571129e-06 2066 1.50613687973475 -1.49482768321487 -1 7.51394043060676 4095 2986 2643 2457 2092 2776 3803 2752 2066 3329 2396 2866 M15384 GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. 12/37 Gene Ontology BP GO:0099601 0.00293114504381181 0.0041365673065101 3300 2422.63636363636 2752 0.000266823420148972 842 1.46593698423963 -1.12659342044625 -1 4.13888020058684 3298 1108 1791 1143 3118 3617 3818 2802 842 2360 2752 2867 M16786 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. 12/19 Gene Ontology BP GO:1990440 1.38637999535261e-05 3.24934998405966e-05 2755 2537.18181818182 2752 1.2603533927439e-06 229 2.29335014955667 2.98932591286817 1 12.1932913398609 2752 3526 2065 2527 2628 3589 3479 229 469 3708 2937 2868 M13146 GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that modulates I-kappaB kinase/NF-kappaB signaling. 192/420 Gene Ontology BP GO:0043122 1.97923277451802e-06 7.10168297688342e-06 3795 2703.72727272727 2753 1.79930414103593e-07 1205 1.32349551083881 -1.22101892495848 -1 8.07221837271203 3793 1672 2873 3112 1205 1816 3811 3373 2753 2634 2699 2869 M13434 GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. 15/26 Gene Ontology BP GO:0001836 0.0753902214266774 0.0911791607408343 1405 2557.36363636364 2753 0.00710044383625945 1259 1.22731271119007 -1.22731271119007 -1 1.5122019316182 1405 3582 2753 3653 3579 1276 1259 2124 3234 3336 1930 2870 M11332 GO_GANGLIOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 11/27 Gene Ontology BP GO:0001573 0.000989126509044396 0.00148625060889745 3065 2534.63636363636 2754 8.99610457612383e-05 1352 1.58400532017267 -1.43719012181296 -1 5.30639859677192 3062 1352 1461 2067 2922 2929 3703 3369 2732 1530 2754 2871 M11438 GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. 39/164 Gene Ontology BP GO:0030518 0.0481447342228005 0.0594668797543131 3520 2889.45454545455 2754 0.00447561694149324 1506 1.65303801004614 -1.63989044667313 -1 2.4002342448302 3604 3658 2268 2322 3519 2264 3517 3816 1506 2754 2556 2872 M11543 GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 14/32 Gene Ontology BP GO:0046131 0.079385940009097 0.094801676816419 1910 2937.36363636364 2754 0.00749128801768768 1696 0.686185989175764 -0.711939850730658 -1 0.831711682747126 1909 2924 2754 4152 3587 1696 1995 2409 4274 4278 2333 2873 M14814 GO_FEMALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GAMETE_GENERATION.html Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. 47/155 Gene Ontology BP GO:0007292 3.04193394888884e-05 6.33349745501833e-05 4400 3109.63636363636 2754 2.76543273676373e-06 1965 1.37438148149687 -1.27566655873245 -1 6.83541036796847 4397 2622 2128 2260 2100 4210 4178 1965 2754 3777 3815 2874 M10585 GO_FOREBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 5/20 Gene Ontology BP GO:0048853 0.0216806468109074 0.0277538580488125 2755 2795.36363636364 2755 0.00218951203852394 1533 1.53561774604294 -1.53561774604294 -1 2.83177910967675 2755 1875 3609 2520 3413 2477 3311 1533 4045 2968 2243 2875 M13198 GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 14/28 Gene Ontology BP GO:0009218 0.079385940009097 0.094801676816419 1910 2956.36363636364 2755 0.00749128801768768 1697 0.686185989175764 -0.711939850730658 -1 0.831711682747126 1910 2925 2755 4153 3588 1697 1996 2501 4275 4386 2334 2876 M16620 GO_ALCOHOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 31/86 Gene Ontology BP GO:0046164 1.66027824061921e-07 1.61925453573951e-06 4555 2878.27272727273 2756 1.50934396901433e-08 240 1.54930436216491 -1.56700244584859 -1 10.627832678496 4551 2691 1255 2497 240 3375 4443 3885 2756 1771 4197 2877 M13535 GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 203/474 Gene Ontology BP GO:0051348 2.97666616346899e-07 2.21840465441196e-06 2890 2536.54545454545 2757 2.70606051474632e-08 434 1.56747233986368 1.90659014657934 1 10.4985806941369 2890 3302 2025 2593 434 4456 2895 1133 2083 2757 3334 2878 M14088 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. 48/150 Gene Ontology BP GO:0045621 0.000637859957572537 0.000993820061412513 2550 2733.27272727273 2760 5.80040883145772e-05 1555 1.49642041065123 -1.37991565680008 -1 5.32282771313143 2550 3590 1699 3313 2816 2041 2624 3877 3241 1555 2760 2879 M15119 GO_OSTEOBLAST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DEVELOPMENT.html The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. 15/31 Gene Ontology BP GO:0002076 7.64860100177498e-05 0.000142907261373204 4135 2614.45454545455 2760 6.95351538981553e-06 744 1.94489425054738 -2.0682296324481 -1 8.85858227237927 4135 2760 1556 811 2365 3265 3566 3214 744 2121 4222 2880 M10603 GO_MICROTUBULE_ANCHORING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ANCHORING.html Any process in which a microtubule is maintained in a specific location in a cell. 11/22 Gene Ontology BP GO:0034453 0.000164541285156787 0.000284213239204971 3130 3029.18181818182 2761 1.49594175212662e-05 2202 0.847519492703858 -0.780633909216475 -1 3.56049093904335 3129 2202 3184 2754 2559 2549 4322 2731 2761 4208 2922 2881 M11596 GO_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BINDING.html Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. 8/21 Gene Ontology BP GO:1900120 0.0965641031282661 0.108954345279353 1145 2750.54545454545 2761 0.0101036240851146 1142 1.43585804499691 1.43585804499691 1 1.6375898765006 1142 2708 3775 2761 3631 2080 1708 2791 3956 3373 2331 2882 M15329 GO_NUCLEOSIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSPORT.html The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/20 Gene Ontology BP GO:0015858 7.15876047889257e-05 0.000134404063499791 3165 2737.63636363636 2761 6.50817584935006e-06 1355 0.985420032734936 1.25799658312349 1 4.51947946281754 3165 1355 2717 2208 2348 3629 2761 3526 2289 2941 3175 2883 M16358 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE.html Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. 13/40 Gene Ontology BP GO:0043576 0.0839184282471183 0.0949861682962873 2740 2932.18181818182 2761 0.00793650793650794 1634 1.40634400890863 1.24541059200418 1 1.70319524867038 2740 2516 2654 3206 3961 2761 1634 3527 3261 2489 3505 2884 M11093 GO_OOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOGENESIS.html The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. 35/107 Gene Ontology BP GO:0048477 0.000809710034494761 0.00123545306939178 3805 2804.09090909091 2763 7.36371092667009e-05 1272 1.3979563433381 -1.35847692525369 -1 4.81606022045865 3803 2586 2212 2138 2880 3669 4013 1272 1868 3641 2763 2885 M15557 GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. 7/31 Gene Ontology BP GO:2001026 0.000766178000920129 0.00117404767599741 2550 2826.63636363636 2766 7.66442292103489e-05 580 1.32247084032167 1.27361998777102 1 4.590692962486 2548 2766 4422 2721 2890 3312 2372 3267 3674 580 2541 2886 M16434 GO_PROTEIN_O_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. 44/116 Gene Ontology BP GO:0006493 0.000154223021780707 0.000268085919179267 4520 3089.63636363636 2767 1.402125764432e-05 1682 1.20946133341509 -1.20932146167892 -1 5.11738488630493 4518 1682 2767 2460 2538 3712 4297 3365 1901 2728 4018 2887 M10822 GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. 29/53 Gene Ontology BP GO:0043496 4.16704545841324e-06 1.21726937563556e-05 3975 2626.27272727273 2768 3.78823031934836e-07 727 1.77086660672678 -0.888845486163816 -1 10.309870999878 3973 1901 2097 1373 1496 4112 4042 2768 727 3345 3055 2888 M13119 GO_GAS_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAS_TRANSPORT.html The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/23 Gene Ontology BP GO:0015669 0.000457747049885174 0.000731104077267583 2650 2959.81818181818 2768 4.57841366792158e-05 2364 3.39570160190946 -3.39570160190946 -1 12.6149779863296 2648 2364 4016 2659 2768 3295 4009 2449 2883 2526 2941 2889 M13459 GO_ERYTHROCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. 5/16 Gene Ontology BP GO:0043249 0.00644577592563549 0.00876104731344426 1990 2900.45454545455 2770 0.0006464549222043 1715 0.845190723269774 0.845190723269774 1 2.0599680599274 1988 2770 4078 3301 3264 2207 1937 1715 3972 4413 2260 2890 M10650 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. 15/55 Gene Ontology BP GO:0032731 0.00051029209846591 0.000809735547907457 3380 2963.09090909091 2772 4.64009545141137e-05 2109 1.51397218086784 1.50675699247614 1 5.54481603592432 3379 2556 2130 3230 2772 4160 2596 2511 3704 2109 3447 2891 M10306 GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING.html Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. 18/62 Gene Ontology BP GO:0010955 0.00015844357860274 0.000274600050560851 2775 2706.90909090909 2774 1.44049991663279e-05 1340 1.37977211352716 1.35494498064807 1 5.82094940363658 2774 2315 2090 3167 2546 3097 2607 3297 3257 1340 3286 2892 M13770 GO_OXIDATION_REDUCTION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATION_REDUCTION_PROCESS.html A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. 435/1065 Gene Ontology BP GO:0055114 5.07427707306622e-06 1.41841471705277e-05 2385 2625.18181818182 2775 4.61298979715563e-07 1140 1.40829464167714 -1.23557523498614 -1 8.08819803623709 2384 3272 2786 4445 1568 1140 2922 2634 2775 3214 1737 2893 M16220 GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. 18/62 Gene Ontology BP GO:1903318 0.00015844357860274 0.000274600050560851 2775 2707 2775 1.44049991663279e-05 1351 1.37977211352716 1.35494498064807 1 5.82094940363658 2775 2316 2091 3168 2547 3098 2608 3278 3258 1351 3287 2894 M10641 GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. 23/66 Gene Ontology BP GO:2000351 6.35457120182948e-07 3.30025437249377e-06 4615 2843.45454545455 2776 5.77688457937355e-08 765 1.35961271608942 -1.10671653823945 -1 8.82854019176224 4615 1482 1185 1873 765 3718 4325 4532 2776 1896 4111 2895 M12018 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. 205/532 Gene Ontology BP GO:0000226 9.24639371687447e-07 4.19657927932045e-06 2175 2854.09090909091 2776 8.40581600277211e-08 911 1.44912229083575 1.60490622103744 1 9.23063422214708 2174 4221 2776 3715 911 3472 2361 1989 2726 3998 3052 2896 M14749 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN.html An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. 15/224 Gene Ontology BP GO:0002455 0.000526651080467649 0.000834553230925357 3365 2911.63636363636 2776 4.78888360074518e-05 1681 1.5066785307224 1.42698322101909 1 5.49470283484752 3364 1853 1681 2194 2776 4431 4470 2211 2970 2120 3958 2897 M10929 GO_ACTIVATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_GTPASE_ACTIVITY.html Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. 52/108 Gene Ontology BP GO:0090630 6.81851994321821e-06 1.7979265119526e-05 2975 2622.63636363636 2777 6.19867370557687e-07 1655 1.51074850668794 1.77137269342061 1 8.4923381654685 2971 2777 1893 2915 1655 3806 2891 2006 2374 2159 3402 2898 M11757 GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of phospholipid metabolic process. 48/120 Gene Ontology BP GO:1903725 0.000417658690796492 0.000670535719698517 1420 2710.36363636364 2778 3.79761820211238e-05 1416 1.33861722936071 1.41975634427777 1 5.03249735303925 1416 3461 2193 3335 2738 2778 2284 1876 3410 3306 3017 2899 M10835 GO_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_LOCALIZATION.html Any process in which is the spindle is transported to, and/or maintained in, a specific location. 26/67 Gene Ontology BP GO:0051653 0.000535461406682066 0.000847068930570641 1835 2554.90909090909 2780 4.86901616262644e-05 1003 2.50290285920484 2.75173887811592 1 9.10866465156653 1834 4032 2116 3453 2780 2999 2126 1497 1003 3101 3163 2900 M14459 GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. 35/106 Gene Ontology BP GO:0046888 0.000537191759282019 0.000849516804613901 1855 2668 2781 4.88475431443965e-05 1505 1.43220090876976 1.46903756784242 1 5.20999614506142 1853 2309 1505 3125 2781 2902 2135 4044 3414 2100 3180 2901 M12528 GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING.html Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. 8/18 Gene Ontology BP GO:0006349 0.000166007533365633 0.000286639262706075 1895 2429.27272727273 2784 1.66019935995152e-05 541 2.87605451965866 -2.87605451965866 -1 12.0699413331466 1891 3560 3925 4069 4116 793 720 541 2784 3381 942 2902 M11731 GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/100 Gene Ontology BP GO:0032370 0.000317082577726864 0.000520033348069879 3010 3115 2785 2.88298443244668e-05 1979 1.65735637529113 2.21498202954225 1 6.44752321747143 3008 2785 1979 2456 2684 4547 4337 4279 2619 2870 2701 2903 M12830 GO_LYMPHANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHANGIOGENESIS.html Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. 4/15 Gene Ontology BP GO:0001946 0.00395561262670004 0.00550042211014324 2220 2826.54545454545 2785 0.000396267140900116 1005 1.85836770731583 -1.85836770731583 -1 4.97441410542013 2217 4354 3966 3575 4641 1812 2020 3606 1111 2785 1005 2904 M14795 GO_PHOSPHOLIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORT.html The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. 26/68 Gene Ontology BP GO:0015914 0.000543814132758365 0.000858819394012616 2950 2694.27272727273 2785 4.94498730687014e-05 1392 1.94226004466453 2.11588124867932 1 7.05458431342867 2950 2464 1831 2276 2785 4306 3501 3011 1392 1721 3400 2905 M15350 GO_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_CAPPING.html Any process that modulates the frequency, rate or extent of telomere capping. 10/26 Gene Ontology BP GO:1904353 1.05531563041404e-05 2.59387531604679e-05 2110 2504.09090909091 2785 9.59382447891107e-07 117 1.58206462825643 -1.58206462825643 -1 8.59490554568839 2106 4106 2785 3964 4255 567 466 1345 4245 3589 117 2906 M11898 GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. 13/28 Gene Ontology BP GO:1903205 0.00282533276915655 0.00399939635585179 3260 2941.27272727273 2786 0.000257178883430347 2262 1.53220316179255 -1.01056339656113 -1 4.35255705361061 3256 3375 2394 2778 3110 3224 2262 4193 2786 2473 2503 2907 M12905 GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT.html The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 7/35 Gene Ontology BP GO:0007603 5.57429316486513e-05 0.000107749555222601 2910 2835.09090909091 2786 5.57443299715106e-06 1361 1.62587298873316 1.18944892673502 1 7.64171450833942 2907 1361 3978 2662 2304 3484 2217 2786 2999 2382 4106 2908 M13080 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. 4/18 Gene Ontology BP GO:2000258 0.200498803750583 0.220753129194678 2145 2899.63636363636 2786 0.0221282231384939 1385 1.45455665270868 1.45455665270868 1 1.13050786444807 2145 2996 4008 3458 4251 1909 1385 2532 3775 2786 2651 2909 M14425 GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. 33/76 Gene Ontology BP GO:0009168 0.000484367354590308 0.000771498328426346 2295 2834.72727272727 2787 4.40430935608931e-05 1752 1.05423630268287 -1.18719731059689 -1 3.88730184691434 2295 3788 3176 3186 2763 2290 2469 1752 3118 3558 2787 2910 M15287 GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 13/42 Gene Ontology BP GO:0071392 0.000544830538080119 0.000859839628927938 1970 2370.45454545455 2787 4.95423192995822e-05 1148 2.66721817236969 -2.21338196512368 -1 9.68611412996856 1967 3376 1473 2989 2787 1496 1148 3250 3008 3182 1399 2911 M15156 GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 33/76 Gene Ontology BP GO:0009127 0.000484367354590308 0.000771498328426346 2300 2836.72727272727 2788 4.40430935608931e-05 1764 1.05423630268287 -1.18719731059689 -1 3.88730184691434 2296 3789 3177 3187 2764 2291 2470 1764 3119 3559 2788 2912 M10522 GO_RESPONSE_TO_MUSCLE_STRETCH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_STRETCH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. 12/33 Gene Ontology BP GO:0035994 0.000546482237795539 0.000862153255210564 3150 2716.81818181818 2789 4.96925483423209e-05 1473 2.07984379962427 2.54746775453534 1 7.55016389258843 3146 2108 1480 1839 2789 4465 3750 3677 1473 2341 2817 2913 M10715 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. 56/147 Gene Ontology BP GO:0070664 0.000223394538513609 0.000377858230352891 3535 3137.09090909091 2789 2.03106568985723e-05 1476 1.63585473638049 -1.55305861687459 -1 6.63266246777203 3532 2684 1476 2638 2615 4559 3978 4227 2789 1778 4232 2914 M12800 GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. 20/41 Gene Ontology BP GO:2000272 9.80594461818578e-05 0.000178195698090946 4255 3062 2790 8.91489247335315e-06 1259 1.32442465312778 1.45022601992157 1 5.88210240087209 4251 1259 2095 2355 2431 4144 4635 3358 2790 2135 4229 2915 M16855 GO_STEROID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 13/65 Gene Ontology BP GO:0006706 4.8742813877201e-05 9.6058100522854e-05 4390 2951.90909090909 2790 4.43126307708447e-06 959 2.57971287462067 -3.0017839602693 -1 12.2772648262672 4388 3183 959 2423 2237 3889 4299 2790 2297 1859 4147 2916 M10380 GO_ANTIMICROBIAL_HUMORAL_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIMICROBIAL_HUMORAL_RESPONSE.html An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. 40/176 Gene Ontology BP GO:0019730 0.0014016206605438 0.00205810396170299 2070 2561.09090909091 2793 0.000127501311888992 1244 2.16172170287876 -1.82966513005307 -1 6.87970645311205 2070 2626 1244 2859 2982 1748 2829 3506 2793 2874 2641 2917 M10467 GO_MYELOID_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 68/127 Gene Ontology BP GO:0002262 5.11734366209408e-07 2.93331192877813e-06 3150 2422.36363636364 2793 4.65213168402002e-08 256 1.37989682745456 1.64459133087475 1 9.04392988748431 3149 256 2793 1236 666 4229 3768 2290 2003 3037 3219 2918 M11987 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. 23/58 Gene Ontology BP GO:0032715 0.000451258980232784 0.000721237674774807 2925 2738.36363636364 2794 4.10319607303832e-05 672 1.41150394630717 -1.27083855338854 -1 5.25358063733227 2923 3431 2473 3088 3030 2766 3761 672 2794 2423 2761 2919 M14842 GO_THALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THALAMUS_DEVELOPMENT.html The process in which the thalamus changes over time, from its initial formation to its mature state. 4/31 Gene Ontology BP GO:0021794 0.36678062969718 0.393748546516533 2310 3025.72727272727 2795 0.0446655936063336 2262 1.04235288485935 1.04235288485935 1 0.499817630248854 2307 3025 4301 2262 4262 2596 2318 2552 4051 2795 2814 2920 M14855 GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 18/30 Gene Ontology BP GO:0032878 0.018102147901137 0.0233662142632691 2190 2643.09090909091 2795 0.00165934869282299 1373 1.54300839336164 -1.54300839336164 -1 2.98201417290357 2189 3151 1774 3170 3869 2343 2795 1456 3931 3023 1373 2921 M11834 GO_ERBB2_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB2_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 26/61 Gene Ontology BP GO:0038128 0.0839184282471183 0.0949861682962873 2800 3058.45454545455 2796 0.00793650793650794 1879 1.93807145187367 1.94050404582691 1 2.34716041148486 2796 3968 1879 3226 4515 3767 2776 2305 2272 3600 2539 2922 M15702 GO_NEGATIVE_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APPETITE.html Any process that reduces appetite. 6/12 Gene Ontology BP GO:0032099 0.00179624403569454 0.00259650095197065 2415 2945.90909090909 2798 0.000179769761127159 2063 2.48821793095678 2.48821793095678 1 7.62131117926206 2413 2739 4442 2789 3055 2809 2063 2798 3761 3155 2381 2923 M16616 GO_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_BACTERIUM.html Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 113/539 Gene Ontology BP GO:0042742 9.04110599266524e-05 0.000165789317235169 3015 2704.72727272727 2798 8.21952506069082e-06 688 1.91926899982976 -2.07704871717652 -1 8.59521237878989 3015 2536 688 3526 2406 2875 4004 2373 3068 2463 2798 2924 M11433 GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. 34/79 Gene Ontology BP GO:0032922 0.000189356361659773 0.000324780785809504 4485 3191.09090909091 2799 1.72156965208433e-05 2362 1.58635259560782 1.87650755154793 1 6.55549055034013 4483 3828 2362 2413 2577 2799 3950 3492 2685 2429 4084 2925 M15503 GO_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_CHEMOTAXIS.html The movement of a monocyte in response to an external stimulus. 13/54 Gene Ontology BP GO:0002548 0.000102507430825536 0.00018549155254056 3585 2873.81818181818 2799 9.31929158161356e-06 682 2.10802447079909 -2.35019840025123 -1 9.31874837111113 3582 1643 682 1960 2440 4536 4553 4274 2799 862 4281 2926 M11667 GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 227/602 Gene Ontology BP GO:0045088 6.59559075777903e-07 3.38753627083717e-06 2790 2693.36363636364 2800 5.99599339557746e-08 779 1.29946707336063 -1.20859639240695 -1 8.42053788798797 2788 3759 2800 4115 779 1154 2315 3105 3263 3539 2010 2927 M16380 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 10/23 Gene Ontology BP GO:0016447 0.0159786017335228 0.0207636853760835 2580 3029.27272727273 2802 0.00146325893302812 1421 0.59099889491917 -0.63365473054087 -1 1.17806620982632 2577 2763 3041 3738 3923 2077 2802 1421 4101 4607 2272 2928 M13759 GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of a protein along a microtubule, mediated by motor proteins. 19/44 Gene Ontology BP GO:0098840 0.0107380012939805 0.0141637897749861 1145 2195.45454545455 2804 0.00098097940628762 594 0.970391191042298 0.991658642714789 1 2.12529567307958 1144 1190 2925 2804 3591 808 594 2956 3378 3080 1680 2929 M16836 GO_INTRACILIARY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT.html The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. 19/44 Gene Ontology BP GO:0042073 0.0107380012939805 0.0141637897749861 1145 2185.18181818182 2805 0.00098097940628762 595 0.970391191042298 0.991658642714789 1 2.12529567307958 1145 1191 2926 2805 3592 809 595 2826 3379 3088 1681 2930 M10943 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html The directed movement of a protein to a specific location on a chromosome. 11/20 Gene Ontology BP GO:0070199 0.00572562725116478 0.00782114955197354 1695 2537 2806 0.000521871186215698 1163 1.029982701377 -0.76289340795969 -1 2.57049347799253 1691 3044 2806 3475 3620 1545 1807 1163 3740 2916 2100 2931 M11164 GO_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 13/34 Gene Ontology BP GO:0010874 0.0113027167571559 0.014862936915594 3070 3021.63636363636 2806 0.00103283697363914 1896 2.07607191740306 2.07607191740306 1 4.49543440235055 3067 2560 2344 1896 3316 4375 4622 2346 2741 3165 2806 2932 M15049 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. 39/76 Gene Ontology BP GO:0072332 7.79094675583429e-06 2.00851559063512e-05 4210 3009.90909090909 2807 7.08270395123459e-07 1460 1.67970050203267 -0.890258183297864 -1 9.34634857568446 4210 2807 2452 2639 1684 3438 4366 2366 1460 3775 3912 2933 M15635 GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. 10/22 Gene Ontology BP GO:0000097 0.000197151969926606 0.000336659285167058 3290 2876 2807 1.79245127113629e-05 1175 1.87478979381951 1.39967310273171 1 7.71279052445056 3288 2203 2301 2807 2586 3621 2884 4281 1175 2086 4404 2934 M10262 GO_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 112/205 Gene Ontology BP GO:0010212 9.90511029068885e-05 0.000179786657856405 2100 2644.63636363636 2808 9.00505116258702e-06 1217 1.59189491366257 2.15704929921087 1 7.0627257245557 2096 3000 1850 3131 2434 3977 2870 1217 2180 3528 2808 2935 M12463 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. 6/12 Gene Ontology BP GO:0032096 0.00179624403569454 0.00259650095197065 2415 2895.90909090909 2808 0.000179769761127159 2062 2.48821793095678 2.48821793095678 1 7.62131117926206 2412 2738 3911 2788 3054 2808 2062 2816 3760 3126 2380 2936 M16494 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 12/42 Gene Ontology BP GO:0003071 1.69600745517418e-05 3.87909488392793e-05 4105 2885.72727272727 2811 1.54183684549856e-06 1660 1.73094679049406 1.8369349544004 1 9.04534923787696 4102 2440 1660 2811 1910 3035 4539 3070 2379 1665 4132 2937 M11767 GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 82/223 Gene Ontology BP GO:0043433 1.30584260613472e-05 3.09674449907567e-05 2815 2638.72727272727 2812 1.18713668838314e-06 960 1.29365792267784 -1.03594521801351 -1 6.91013922821765 2812 3108 2464 4072 1836 960 2422 3074 2925 3356 1997 2938 M15857 GO_2_OXOGLUTARATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_OXOGLUTARATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. 11/25 Gene Ontology BP GO:0006103 0.0604938304292498 0.0738361868251859 2465 2872.45454545455 2812 0.00565674848511509 1686 0.929623419872944 -0.922712056773238 -1 1.24631460475121 2464 3321 2812 3128 3615 2185 1686 2725 4232 3661 1768 2939 M16686 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of hydrogen ion (proton) across a membrane. 44/121 Gene Ontology BP GO:1902600 0.000633381827655059 0.000988169296304582 755 2174.63636363636 2812 5.7596750212906e-05 493 1.15416980272783 -0.985507300079534 -1 4.10881398369486 754 3245 3336 3421 2812 493 680 1393 3072 3859 856 2940 M10890 GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. 30/70 Gene Ontology BP GO:0045600 0.000635959008613486 0.000991190895264323 3485 2756 2815 5.78311746514446e-05 1382 1.82621713400125 -1.66330416220374 -1 6.49841717947124 3482 3574 1382 1890 2815 4508 4062 2255 1870 1629 2849 2941 M12035 GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. 11/36 Gene Ontology BP GO:0060706 0.000154481913043453 0.000268435449947886 4335 3038 2815 1.40447965166683e-05 1248 1.4362048168727 0.840903885118724 1 6.07580301227354 4335 2815 2170 2715 2539 4442 3956 1248 2174 2925 4099 2942 M14388 GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. 10/28 Gene Ontology BP GO:0014874 6.79678732216786e-07 3.4376343722032e-06 4060 2824.09090909091 2817 6.17889947454672e-08 796 1.35717320961119 -1.31789250973228 -1 8.78422287984962 4059 2609 2300 2817 796 3336 3438 2747 3157 2077 3729 2943 M11580 GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that activates or increases the frequency, rate, or extent of a homeostatic process. 110/279 Gene Ontology BP GO:0032846 0.0352734221225981 0.0442394648609463 2590 2796.18181818182 2818 0.00325927307106546 1314 1.62246699794348 1.73995351046332 1 2.60275529412271 2588 3567 1314 3271 3463 4366 3512 2500 2818 1426 1933 2944 M15770 GO_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_KILLING.html Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 31/141 Gene Ontology BP GO:0001906 5.69353507880508e-07 3.12841223324166e-06 4325 2909.09090909091 2820 5.17594232025062e-08 714 1.22194027855279 -1.01451704019726 -1 7.96819134347318 4321 1625 2820 2370 714 2042 3494 4387 2686 3774 3767 2945 M16565 GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of establishment of protein localization. 348/851 Gene Ontology BP GO:1904951 1.23867130193325e-05 2.97063577214673e-05 2650 2711.72727272727 2820 1.12607116009919e-06 1564 1.55817390938003 1.78516156233563 1 8.35639352125629 2649 3358 1564 2841 1811 4076 2993 3090 2163 2464 2820 2946 M16793 GO_PROGESTERONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROGESTERONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. 6/26 Gene Ontology BP GO:0042448 0.01632712821045 0.0211869357968472 2805 3172.63636363636 2820 0.00164483423209736 2043 0.763714426956808 -0.763714426956808 -1 1.51442017544593 2804 2678 4619 2820 3374 2518 2408 2043 4026 4633 2976 2947 M15826 GO_STEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 60/191 Gene Ontology BP GO:0016125 4.36684944880167e-07 2.71786621860404e-06 4350 2433.90909090909 2823 3.96986392326512e-08 82 1.3640444937128 1.34420239813777 1 8.99356676326633 4349 82 1087 1741 593 2873 4152 3057 2823 1425 4591 2948 M16729 GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 13/23 Gene Ontology BP GO:0048569 0.00114436827396021 0.00170080086299529 1380 2607.54545454545 2823 0.000104087633716264 869 0.78583012811707 0.824683330251733 1 2.57800524575325 1377 3608 2823 4217 2950 1938 1230 869 3615 3763 2293 2949 M14209 GO_NEGATIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_T_CELL_SELECTION.html The process of elimination of immature T cells which react strongly with self-antigens. 7/20 Gene Ontology BP GO:0043383 0.00526490584053482 0.00723651800402699 1730 2618.90909090909 2824 0.000527742124768952 1024 1.08740129226664 1.08740129226664 1 2.75725478131223 1727 2824 4204 3267 3235 1987 1024 1447 3786 3288 2019 2950 M12923 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rac protein signal transduction. 10/20 Gene Ontology BP GO:0035020 3.79808575423429e-07 2.57804519639595e-06 3010 2735.09090909091 2825 3.45280582721542e-08 514 1.40129576427673 -1.76370233612345 -1 9.27725226021902 3009 2606 2087 1732 514 3377 4033 4271 4083 2825 1549 2951 M15322 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein. 9/31 Gene Ontology BP GO:0042522 0.0160565893734438 0.0208591898323725 2400 2973.63636363636 2825 0.00161737993998859 2306 1.26674725584729 1.10603295182284 1 2.52207877174732 2399 2991 4385 2562 3373 2825 2381 2954 3837 2697 2306 2952 M10409 GO_SINGLE_ORGANISM_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. 66/146 Gene Ontology BP GO:0044801 0.000179502040037704 0.000308677026627799 2365 3087.27272727273 2826 1.63196988738167e-05 2083 1.38780413904206 -1.46623897354205 -1 5.77131259528815 2361 4182 3169 4581 2568 2083 2826 2571 3497 3993 2129 2953 M14198 GO_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MIGRATION.html The movement of a T cell within or between different tissues and organs of the body. 6/27 Gene Ontology BP GO:0072678 0.0105061789717038 0.0138935314627231 1625 2765.36363636364 2826 0.00105561829243537 1340 1.14390135854458 -0.636933935209298 -1 2.51664584843774 2055 2826 4202 3698 4099 1621 1625 1340 4018 3146 1789 2954 M12562 GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 6/20 Gene Ontology BP GO:0045076 0.000609078492091378 0.000954421680317336 3435 2623 2827 6.0924549599097e-05 894 1.99395325910777 -1.90340476578121 -1 7.13406827455208 3434 1520 3932 1783 2827 3733 1870 3796 894 1302 3762 2955 M14541 GO_POSITIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WOUND_HEALING.html Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 25/85 Gene Ontology BP GO:0090303 0.00171242989434264 0.00248929618016057 3035 2800.27272727273 2827 0.000155796751372654 1580 1.50015758846152 1.58138258633569 1 4.62746386332127 3031 2692 1580 2636 3027 3871 2827 2484 3318 1607 3730 2956 M13184 GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 9/16 Gene Ontology BP GO:0010870 0.0443040233138713 0.0549128617849184 2200 3038.63636363636 2829 0.00452129130216426 1695 1.44600422319382 1.86904662551532 1 2.15888840416628 2198 3297 4030 2829 4145 2752 2035 4043 3714 2687 1695 2957 M16059 GO_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 391/1000 Gene Ontology BP GO:0030162 1.57345731110856e-06 6.04654396216291e-06 2830 2546.54545454545 2829 1.43041676041703e-07 1109 1.65350252019658 1.91028537920556 1 10.2218141097021 2829 3457 1189 3003 1109 4344 3765 1398 2027 1594 3297 2958 M11550 GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. 2/15 Gene Ontology BP GO:0021521 0.000533916738046365 0.000844913229294231 3135 2639.1 2830 5.93381641261926e-05 697 1.53003930582573 1.53003930582573 1 5.57018566674814 3131 733 3767 NA 2818 3634 2842 3839 697 2288 2642 2959 M13235 GO_GLYOXYLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYOXYLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. 18/32 Gene Ontology BP GO:0046487 0.000417996657536374 0.000670846346678666 1565 2441.72727272727 2831 3.80069179452618e-05 718 1.07842542050861 -0.971700393313951 -1 4.05405559076341 1564 2980 2831 3853 2739 939 718 2962 3608 3548 1117 2960 M15625 GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION.html The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. 2/15 Gene Ontology BP GO:0060573 0.000533916738046365 0.000844913229294231 3135 2707 2831 5.93381641261926e-05 698 1.53003930582573 1.53003930582573 1 5.57018566674814 3132 734 4432 NA 2819 3635 2843 3838 698 2296 2643 2961 M10055 GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION.html The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. 7/24 Gene Ontology BP GO:0021801 9.80757762693296e-06 2.43250977146633e-05 845 2032.90909090909 2833 9.80762091206234e-07 120 0.934266252895327 0.934266252895327 1 5.10647337574388 844 3229 3527 2833 3253 525 159 762 3845 3265 120 2962 M10235 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that activates or increases the rate of gene expression. 48/111 Gene Ontology BP GO:0045815 0.000139510080937114 0.000245172333758902 3315 2845.27272727273 2833 1.26835389608439e-05 1197 1.98628057333548 -1.1105437071887 -1 8.49550877678103 3312 3936 1915 2822 2510 2738 3014 2833 1197 3305 3716 2963 M11967 GO_SYNAPTIC_VESICLE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYCLE.html A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. 42/129 Gene Ontology BP GO:0099504 2.49327878128571e-05 5.3743237611465e-05 3195 2721.45454545455 2834 2.26664276206847e-06 1860 1.45847314387621 -1.22805039310241 -1 7.37685721047329 3195 2834 1909 2132 2023 3415 3034 3574 2206 1860 3754 2964 M12797 GO_TELENCEPHALON_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_GLIAL_CELL_MIGRATION.html The orderly movement of glial cells through the telencephalon. 7/24 Gene Ontology BP GO:0022030 9.80757762693296e-06 2.43250977146633e-05 845 2078.27272727273 2834 9.80762091206234e-07 121 0.934266252895327 0.934266252895327 1 5.10647337574388 845 3230 3962 2834 3254 526 160 803 3846 3280 121 2965 M13067 GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 17/33 Gene Ontology BP GO:0010869 0.0839184282471183 0.0949861682962873 3475 2809.45454545455 2834 0.00793650793650794 1776 1.29856557479124 -0.720279912393693 -1 1.57266680257914 2677 2858 1776 2871 3810 3473 2203 2604 3471 2327 2834 2966 M11414 GO_DNA_INTEGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRATION.html The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. 2/7 Gene Ontology BP GO:0015074 0.073532136039832 0.0890943913447129 2020 2929.7 2836 0.00845030698643819 1069 0.368431540624636 0.368431540624636 1 0.458336554779807 2017 2829 3741 NA 3864 2110 1069 2402 4156 4266 2843 2967 M11824 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of extracellular matrix assembly. 7/16 Gene Ontology BP GO:1901201 2.98296535342699e-05 6.22467781391528e-05 3355 2704.81818181818 2836 2.98300539555381e-06 568 1.48508681082174 1.58155558338984 1 7.39923880259145 3355 2040 3813 568 2130 4638 3076 3690 1229 2378 2836 2968 M14968 GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a humoral immune response. 18/65 Gene Ontology BP GO:0002920 0.000237486409335948 0.000399365953838033 3805 2929 2837 2.15920044982954e-05 1599 1.94381090418376 -2.20256120829803 -1 7.82592670923264 3801 2272 1599 3342 2627 3332 3883 4249 1830 2447 2837 2969 M16852 GO_ORGANELLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FUSION.html The creation of a single organelle from two or more organelles. 72/149 Gene Ontology BP GO:0048284 0.000315618691542706 0.000517998439318765 2215 3082 2837 2.86967254778731e-05 1652 1.05519538639287 -1.04980412506451 -1 4.10709694956067 2214 4370 3393 4596 2683 1652 2837 2504 3758 4098 1797 2970 M13181 GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 11/22 Gene Ontology BP GO:0071243 0.00438800023048071 0.00608527033157764 1440 2691.45454545455 2838 0.000399706983097066 791 0.816318720493383 -0.816318720493383 -1 2.14265584104262 1438 3666 2838 4451 4459 791 1326 1756 4219 3655 1007 2971 M16359 GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosyl compound. 63/135 Gene Ontology BP GO:1901659 0.000692380975679592 0.00106979197007665 1320 2743.54545454545 2838 6.29635433570154e-05 1316 1.08916476150375 -0.967517940562367 -1 3.83292557580284 1316 3624 3249 3428 2838 1552 1883 2720 3193 3978 2398 2972 M15054 GO_PARAXIAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARAXIAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. 9/23 Gene Ontology BP GO:0048339 4.4505895235449e-05 8.85350777969964e-05 4345 2587.72727272727 2839 4.45067866091941e-06 369 1.16319700759063 -1.16319700759063 -1 5.58464392703687 1735 3156 4341 2839 4344 1228 2107 369 3494 3507 1345 2973 M15834 GO_CYTOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOLYSIS.html The rupture of cell membranes and the loss of cytoplasm. 18/49 Gene Ontology BP GO:0019835 5.42635059062048e-05 0.00010528435349875 3940 2845 2839 4.93316767038868e-06 1415 1.36361967334903 -1.19155208480556 -1 6.42534278783259 3936 1415 1777 2189 2269 3879 3396 2839 3525 1881 4189 2974 M16619 GO_NUCLEOTIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SALVAGE.html Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. 8/14 Gene Ontology BP GO:0043173 0.000126359692492285 0.000224269133119909 2845 2832 2841 1.2636687811469e-05 715 0.806776925904049 0.830931257077499 1 3.48764808287472 2841 715 4593 2661 2508 2230 1253 4124 3966 3409 2852 2975 M16535 GO_CORTICAL_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. 29/61 Gene Ontology BP GO:0030865 0.000703671625970244 0.00108651392064511 4000 2707.18181818182 2843 6.3990617881433e-05 1168 1.57748851564733 -1.70818858703542 -1 5.53881938818752 4000 3113 1428 1448 2843 4633 3142 2606 1248 1168 4150 2976 M12508 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that activates or increases the frequency, rate or extent of response to oxidative stress. 10/22 Gene Ontology BP GO:1902884 0.0839184282471183 0.0949861682962873 2390 3080.27272727273 2844 0.00793650793650794 1993 1.67772597354963 -1.67772597354963 -1 2.03186087117512 2389 4066 2461 4227 4178 1993 2817 2844 3137 3575 2196 2977 M14667 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 5/14 Gene Ontology BP GO:0032740 0.012966166637892 0.0169774144669296 2845 2608.09090909091 2844 0.00130424484715481 1158 1.29709455190732 -1.29709455190732 -1 2.7199082247185 2844 3197 4269 2949 3656 1949 1158 1391 3023 1982 2271 2978 M10983 GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. 8/17 Gene Ontology BP GO:1903504 4.20460932755248e-05 8.40740788450739e-05 2715 2830 2846 4.2046888839992e-06 1455 1.07086205498801 -1.07086205498801 -1 5.16981630476597 2711 1991 3667 3159 2224 2167 2846 4192 3351 3367 1455 2979 M13858 GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. 31/69 Gene Ontology BP GO:0006687 2.18763361286646e-05 4.81155038585455e-05 4440 3130 2847 1.98877760594244e-06 1990 1.43954427591819 -1.13322687071563 -1 7.36303725718822 4439 2783 2124 2847 1990 4207 3406 3785 2471 2163 4215 2980 M15165 GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. 8/17 Gene Ontology BP GO:0090266 4.20460932755248e-05 8.40740788450739e-05 2715 2897.90909090909 2847 4.2046888839992e-06 1456 1.07086205498801 -1.07086205498801 -1 5.16981630476597 2712 1992 4365 3160 2225 2168 2847 4197 3352 3403 1456 2981 M13912 GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. 5/21 Gene Ontology BP GO:0002921 0.00801621142038385 0.0107694645905215 1745 2622.09090909091 2849 0.000804527592835 549 1.45455665270868 1.45455665270868 1 3.39071105966012 1745 2849 4155 3216 4005 1010 549 2525 3776 2991 2022 2982 M14853 GO_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. 11/21 Gene Ontology BP GO:0030225 0.07528627338337 0.0910771670971826 1640 2812.18181818182 2851 0.00709029658823503 1500 0.933730031428593 0.933730031428593 1 1.15100880340478 1638 3636 2851 4101 3837 1634 1500 2136 4118 3658 1825 2983 M10443 GO_LYSOSOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_TRANSPORT.html The directed movement of substances into, out of or within a lysosome. 50/101 Gene Ontology BP GO:0007041 0.000727916276375152 0.0011217110093627 995 2304.18181818182 2853 6.619611221914e-05 615 1.04494703821453 -1.06289570718647 -1 3.6518398059535 993 3242 3270 3647 2853 615 932 1360 3473 3824 1137 2984 M10446 GO_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 698/1714 Gene Ontology BP GO:0044248 0.000191756436461993 0.00032865453469658 2855 3088.27272727273 2853 1.9177298521072e-05 677 1.49261264783645 -1.19448357980893 -1 6.15901184432207 2853 4575 3586 4598 2599 677 2102 4344 2782 4113 1742 2985 M11962 GO_RESPONSE_TO_NERVE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NERVE_GROWTH_FACTOR.html A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. 27/59 Gene Ontology BP GO:1990089 0.000122850360182613 0.000218709441076639 3055 2821.54545454545 2853 1.11688382558976e-05 1645 1.49013547808858 -1.12911520456154 -1 6.46101199459672 3052 3486 2288 3136 2478 3525 1645 3704 2125 2745 2853 2986 M12146 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. 40/127 Gene Ontology BP GO:0001910 0.000619056493561892 0.000968096766456001 4015 2821.72727272727 2853 5.62937052817486e-05 1020 1.82242079084273 -1.53066180825476 -1 6.50701193469268 4014 2752 1020 1976 2807 3060 4205 3385 2853 1329 3638 2987 M14956 GO_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid oxidation. 13/43 Gene Ontology BP GO:0046320 0.0333027730759547 0.0418923802199018 1645 2902.63636363636 2854 0.00307434976179037 1450 0.842432352893464 0.842432352893464 1 1.37505245147461 1641 3346 2547 3894 3450 1928 1450 2854 4259 4509 2051 2988 M12069 GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 69/221 Gene Ontology BP GO:0002263 4.52916222944529e-06 1.29727947139509e-05 3280 2697.18181818182 2855 4.11742868518565e-07 1497 1.30390786840674 -1.09363757228368 -1 7.54856273720924 3280 3085 2285 2525 1523 1497 3183 3776 2855 2766 2894 2989 M12608 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. 11/24 Gene Ontology BP GO:0048009 0.205732883584307 0.226087048161406 1280 3028.18181818182 2855 0.0207218759682053 1279 0.958699376989495 0.958699376989495 1 0.733342225208571 1279 4501 2855 3835 3736 2330 2103 2293 4110 3653 2615 2990 M14164 GO_REGULATION_OF_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTON_TRANSPORT.html Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/21 Gene Ontology BP GO:0010155 3.05986084413759e-05 6.36796678589459e-05 2620 2786.63636363636 2855 3.05990297732183e-06 713 0.814384393203673 0.960685679549269 1 4.04802104187251 2620 713 4195 2168 2140 2855 1484 4150 3933 3500 2895 2991 M14359 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. 24/59 Gene Ontology BP GO:0060760 9.44472938687363e-05 0.000172441520028526 3510 3097 2855 8.58648625366573e-06 1552 1.64298832186137 1.93934064394395 1 7.32466944923712 3507 2855 1871 1552 2419 4202 4223 4267 2849 2503 3819 2992 M11677 GO_REFLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REFLEX.html An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. 8/41 Gene Ontology BP GO:0060004 0.000667189568364472 0.00103431090681678 2980 2647.45454545455 2857 6.673899669128e-05 1051 1.73014940944666 -1.69752591440656 -1 6.11866513054578 2976 1913 3788 1447 2857 3926 1783 3083 3641 1051 2657 2993 M16971 GO_BRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). 16/55 Gene Ontology BP GO:0048854 4.07686991193764e-05 8.18370384830371e-05 4090 2661 2857 3.70631405754454e-06 506 2.83838711712258 3.4897718026624 1 13.7423066855776 4088 1637 1896 1666 2188 4560 3539 3075 506 2857 3259 2994 M14659 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. 10/28 Gene Ontology BP GO:2000679 0.00148161182746356 0.0021709032992866 2220 2821.18181818182 2858 0.000134782779585368 1916 0.84534590842908 -0.84534590842908 -1 2.66711706217336 2219 2798 2858 2024 2989 2267 3245 3192 3937 3588 1916 2995 M13668 GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. 271/607 Gene Ontology BP GO:0033157 2.25431190986445e-06 7.77288853033298e-06 2860 3053.54545454545 2859 2.04937656348399e-07 1255 1.38465258310354 1.63020228398131 1 8.38089174579117 2657 3758 2859 3846 1255 4406 3016 2683 2267 3984 2858 2996 M15644 GO_GTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GTP, guanosine triphosphate. 14/28 Gene Ontology BP GO:0046039 9.70975627753471e-07 4.30586422126014e-06 4035 2709.72727272727 2861 8.82705505723921e-08 466 0.934121335882213 1.0713617394919 1 5.93782037823025 4031 466 2861 2271 938 3749 4170 1846 2071 3249 4155 2997 M12512 GO_NITROGEN_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_COMPOUND_TRANSPORT.html The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 254/690 Gene Ontology BP GO:0071705 4.05523279248002e-06 1.1924284898977e-05 4100 3036.54545454545 2862 3.68658206132705e-07 1485 1.59613394039187 -1.41913632463512 -1 9.30951949797201 4096 4078 2035 3926 1485 2386 4626 2207 2669 3032 2862 2998 M12961 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 20/47 Gene Ontology BP GO:1902235 0.000280661603630676 0.00046456239207652 3000 2757.54545454545 2862 2.55179468179679e-05 1348 1.14892442582305 -0.973108144721555 -1 4.53627084755347 2998 2977 2862 2345 2663 1348 1772 3935 3524 3673 2236 2999 M15756 GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. 25/50 Gene Ontology BP GO:1904837 0.000743994378248964 0.00114420864465384 3505 2901.27272727273 2862 6.76587364459779e-05 1973 1.14031755101643 -0.931127230175886 -1 3.97348710488969 3505 1973 2647 2746 2862 2075 3753 3411 2454 3065 3423 3000 M14488 GO_NEGATIVE_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JNK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. 26/66 Gene Ontology BP GO:0046329 0.000757801626019774 0.00116390107496189 3325 2842.27272727273 2865 6.89147982492503e-05 1069 2.15571759642655 2.38231803843674 1 7.49277003802278 2758 3831 2564 3955 2865 3324 2392 1333 1069 3849 3325 3001 M15121 GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 22/55 Gene Ontology BP GO:0002756 0.00280995376085581 0.0039788396802847 2125 2694.27272727273 2865 0.000255777200905101 1671 0.948386240894551 -0.908772167595393 -1 2.6966115386488 2125 3630 2933 3307 3109 1982 2379 1671 3544 2865 2092 3002 M14637 GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 11/25 Gene Ontology BP GO:0046386 0.00299894400492078 0.00422582610465771 1575 2568.72727272727 2866 0.000273003623023713 1110 0.653574987431385 -0.653574987431385 -1 1.8381037014759 1575 2866 3065 3751 3121 1213 1110 1146 4077 4492 1840 3003 M11297 GO_CARBOHYDRATE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHORYLATION.html The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. 10/24 Gene Ontology BP GO:0046835 0.000109347674880529 0.000196552833646017 1470 2349 2868 9.94119183815088e-06 373 0.857382492109385 -0.857382492109385 -1 3.76460094878895 1466 3501 2935 3266 2868 1008 1939 988 3928 3567 373 3004 M10868 GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 10/20 Gene Ontology BP GO:0090153 0.00212639875996259 0.00304812270531222 3060 2761.45454545455 2870 0.00019349607320267 1592 1.70145331900373 -2.83367012658679 -1 5.071110010908 3057 2989 2107 2835 3068 3085 2677 1592 2870 3565 2531 3005 M14263 GO_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APPETITE.html Any process which modulates appetite, the desire or physical craving for food. 10/23 Gene Ontology BP GO:0032098 0.206434902159253 0.226804839262994 1945 3056.72727272727 2870 0.0208005932213567 1943 2.48821793095678 2.48821793095678 1 1.89926866851777 1943 4103 2470 3952 3773 2621 2172 2252 3881 3587 2870 3006 M15275 GO_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_MOVEMENT.html A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. 122/278 Gene Ontology BP GO:0007018 0.000288380391732202 0.000476325207688585 2000 2835.72727272727 2870 2.62198363771103e-05 969 1.30991817469038 1.33849600330242 1 5.15506757927756 2000 3653 2870 4088 2668 2189 969 3474 3202 3897 2183 3007 M11494 GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. 10/20 Gene Ontology BP GO:1905038 0.00212639875996259 0.00304812270531222 3060 2764.27272727273 2871 0.00019349607320267 1610 1.70145331900373 -2.83367012658679 -1 5.071110010908 3058 2990 2108 2836 3069 3086 2678 1610 2871 3569 2532 3008 M11511 GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 24/83 Gene Ontology BP GO:0048260 1.35371333629991e-05 3.19049280531935e-05 4090 2831.72727272727 2872 1.23065606008911e-06 842 1.65109683500098 -1.69590489134585 -1 8.79408390027516 4087 2193 1496 2613 1849 3932 4618 3641 3006 842 2872 3009 M16892 GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. 8/20 Gene Ontology BP GO:0042789 0.0273728127125886 0.0347720846578793 1695 2757.27272727273 2873 0.00277159483914038 792 1.43226303933145 1.43226303933145 1 2.47506835686488 1693 2116 4633 2873 3700 2156 792 3249 4085 3411 1622 3010 M10168 GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of mitosis. 24/63 Gene Ontology BP GO:0045840 0.028423554027827 0.0360378376163847 3505 3023.27272727273 2874 0.00261796030044886 1589 1.92024157390542 1.4966101508485 1 3.28301364866587 3504 4289 1629 3655 4373 2636 2874 1589 3340 2501 2866 3011 M12872 GO_PROTEIN_O_LINKED_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_FUCOSYLATION.html The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. 6/19 Gene Ontology BP GO:0036066 0.000711589383624629 0.00109837417159879 3735 2806.36363636364 2874 7.11817348121739e-05 1038 1.32752377323963 -1.64811701206332 -1 4.65373728225407 3733 1038 3973 2359 2874 3062 3677 2758 1903 2183 3310 3012 M11042 GO_POSITIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOR_SIGNALING.html Any process that activates or increases the frequency, rate or extent of TOR signaling. 18/31 Gene Ontology BP GO:0032008 0.000786923211965975 0.00120384990878353 2780 2737.63636363636 2875 7.15640754026747e-05 1219 1.03590504054244 -0.742456123469459 -1 3.58257723463197 2776 2952 3019 3750 2875 1219 1755 2148 3688 3887 2045 3013 M11335 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. 19/45 Gene Ontology BP GO:0002475 0.0839184282471183 0.0949861682962873 2875 2975.54545454545 2875 0.00793650793650794 2020 1.93716980637674 -1.26958538923714 -1 2.3460684454844 2875 3496 2252 2827 3836 2471 3175 4126 2318 2020 3335 3014 M10052 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 6/19 Gene Ontology BP GO:0071402 0.0219676557111449 0.0281057661798969 3530 2691.90909090909 2876 0.00221878860386555 739 1.60578086760453 1.60578086760453 1 2.95075539010206 1778 2876 3526 3527 4207 1847 739 2070 4023 3104 1914 3015 M13134 GO_CELL_SEPARATION_AFTER_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SEPARATION_AFTER_CYTOKINESIS.html The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components. 10/17 Gene Ontology BP GO:0000920 0.00569819868617191 0.00778597307236497 1165 2522.45454545455 2877 0.000519364661419478 493 0.561131961762008 -0.561131961762008 -1 1.4016988884568 1162 3502 2877 3235 3904 641 493 1766 4543 4383 1241 3016 M14513 GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organonitrogen compound. 923/2218 Gene Ontology BP GO:1901564 6.83640715688518e-06 1.79991788410912e-05 2880 2842.18181818182 2877 6.83642818838451e-07 1191 1.45040771822162 -1.20545976613223 -1 8.15231969489478 2877 3166 4246 4143 1676 1191 2109 3218 2339 3815 2484 3017 M16149 GO_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. 418/971 Gene Ontology BP GO:0032386 9.31159503993847e-07 4.20152922939109e-06 2880 3049.90909090909 2877 8.46508998283058e-08 920 1.39322821563193 1.63551018759424 1 8.87375454047366 2684 3850 2736 3786 920 4368 2935 2877 2641 3876 2876 3018 M12249 GO_EPITHELIAL_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_CELL_ADHESION.html The attachment of an epithelial cell to another epithelial cell via adhesion molecules. 9/22 Gene Ontology BP GO:0090136 6.03607979977902e-05 0.000115569148496388 2115 3014.90909090909 2878 6.03624376021408e-06 1966 0.796571405396689 0.72270809383824 1 3.71522799565937 2111 2643 3877 2878 2332 2627 1966 3884 3303 4325 3218 3019 M12385 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE.html A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 6/15 Gene Ontology BP GO:0033540 0.00039682222587557 0.000639738053729262 1420 2354.09090909091 2878 3.96893104234947e-05 555 0.822469953346467 -0.822469953346467 -1 3.1119493719404 1420 2878 3900 3261 3190 730 555 664 3861 4335 1101 3020 M13787 GO_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. 78/260 Gene Ontology BP GO:0050707 3.71860650970274e-06 1.11678460702133e-05 4555 2842.72727272727 2878 3.38055708653434e-07 948 1.63379160053123 -1.75283128339721 -1 9.58424710605165 4553 2492 948 1707 1452 3772 3908 4296 2878 1289 3975 3021 M14354 GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. 55/137 Gene Ontology BP GO:0006733 0.00314483685780832 0.00441532432138012 1470 2424.63636363636 2878 0.000286303757185035 933 1.2148539020828 -1.16730400909046 -1 3.38921988538553 1470 3143 2878 3560 3168 948 1307 2452 3199 3613 933 3022 M11242 GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html The directed killing of a target cell by a leukocyte. 26/73 Gene Ontology BP GO:0001909 1.58855486826087e-06 6.08051133828129e-06 3700 2778.09090909091 2880 1.44414183210042e-07 1115 1.15961022556056 -1.02530812961596 -1 7.16527075776775 3696 1177 2880 2630 1115 1896 3620 4548 2898 3847 2252 3023 M16158 GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. 61/126 Gene Ontology BP GO:0046467 1.73725573688423e-06 6.43227941495494e-06 2885 2694.27272727273 2883 1.57932464430006e-07 1164 1.14770035685634 1.33056586103145 1 7.0584716496102 2883 1385 2585 3053 1164 3692 1948 3835 3079 2417 3596 3024 M12503 GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 4/107 Gene Ontology BP GO:0048387 0.197155377335684 0.217174950645215 2745 3031 2884 0.0217200553973794 1977 1.25677581248388 -1.25677581248388 -1 0.98735497914019 2743 3454 3919 3352 3768 1977 2095 2884 4112 2782 2255 3025 M10659 GO_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 67/162 Gene Ontology BP GO:0042157 1.9815666559102e-06 7.10456678254137e-06 2405 2802.72727272727 2887 1.80142585521232e-07 1206 1.10239091127513 1.25026883360672 1 6.72343425260267 2405 2887 3030 3390 1206 3858 2510 2677 3200 3011 2656 3026 M12741 GO_REGULATION_OF_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBRINOLYSIS.html Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. 4/20 Gene Ontology BP GO:0051917 0.313923490361559 0.338570677293547 2540 3067.36363636364 2887 0.0369756796623645 1630 1.00693053441594 1.00693053441594 1 0.561045477853602 2540 3132 3954 3528 4085 2316 1630 2887 4212 2784 2673 3027 M11776 GO_CRISTAE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRISTAE_FORMATION.html The assembly of cristae, the inwards folds of the inner mitochondrial membrane. 5/13 Gene Ontology BP GO:0042407 0.00117578886917063 0.00174526461622737 2890 2807.18181818182 2888 0.000117641144859372 1436 0.482673305747581 -0.482673305747581 -1 1.57705566899542 2888 1955 3803 3558 2966 1553 1436 2803 3796 4287 1834 3028 M13290 GO_REGULATION_OF_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of fatty acid transport. 16/57 Gene Ontology BP GO:2000191 0.000831581773488851 0.00126549792668264 1765 2764.90909090909 2889 7.5626933722796e-05 1255 0.893927240000584 1.09151732095165 1 3.06859261366516 1765 3216 2561 3080 2889 2321 1255 3931 3491 3425 2480 3029 M12387 GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT.html The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. 30/62 Gene Ontology BP GO:0006893 1.55084021234478e-05 3.58950703186281e-05 3750 3031.63636363636 2890 1.40986467704525e-06 1882 1.3574857045923 -1.52343047490763 -1 7.14795201980435 3747 2629 2857 2938 1882 2890 4351 3295 2622 3415 2722 3030 M11312 GO_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 22/50 Gene Ontology BP GO:0010762 2.71499749107819e-06 8.80903798118521e-06 3860 2818.81818181818 2891 2.46818258330419e-07 1329 0.97232741907436 -1.06703282600391 -1 5.82261149237831 3856 1329 2373 1921 1337 3630 4310 3387 2891 2859 3114 3031 M14021 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 29/78 Gene Ontology BP GO:0002066 4.38577873347578e-07 2.7259933948498e-06 2895 2529.18181818182 2891 3.98707237072428e-08 595 1.66524310389139 -1.4896127497826 -1 10.9769046103667 3686 2891 1747 2289 595 2893 3061 4218 1013 1565 3863 3032 M13948 GO_OOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. 18/71 Gene Ontology BP GO:0009994 0.000102501885036305 0.00018549155254056 3975 2601 2892 9.31878737197066e-06 461 1.6956803470884 -1.81176463411761 -1 7.49593659741148 3972 2979 1929 1975 3383 4564 2892 461 1553 3022 1881 3033 M11459 GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. 10/32 Gene Ontology BP GO:0065005 0.000868331355319933 0.00131839845740695 4080 2785.18181818182 2894 7.89703883450656e-05 1430 1.44144096841569 -0.761300684658916 -1 4.9176799645639 4080 1581 2247 2318 2894 3303 3321 2911 1430 2811 3741 3034 M12728 GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. 24/51 Gene Ontology BP GO:1901224 3.33607822924775e-05 6.85675574076906e-05 4460 2884 2895 3.03284438053196e-06 1486 1.59005806343425 -1.50058874860823 -1 7.84312857958499 4458 3337 2027 2100 2135 3196 3914 2895 1972 1486 4204 3035 M13996 GO_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 19/41 Gene Ontology BP GO:0071887 3.90191953759951e-06 1.15465980962871e-05 4225 2896.72727272727 2895 3.54720587096397e-07 1451 1.31070170601097 1.23998006052258 1 7.66642729626982 4223 2022 1773 2255 1477 3745 4420 3203 2895 1451 4400 3036 M11424 GO_RESPONSE_TO_COPPER_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COPPER_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. 20/42 Gene Ontology BP GO:0046688 2.44965640434235e-05 5.29504408070836e-05 3220 2673.81818181818 2898 2.22698516473291e-06 1397 1.44591411608424 1.38711765680969 1 7.32438968133556 3217 1800 1539 1397 2019 4520 3849 3497 3104 1572 2898 3037 M15464 GO_POSITIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_KILLING.html Any process that activates or increases the frequency, rate or extent of cell killing. 31/84 Gene Ontology BP GO:0031343 0.073202788613138 0.0888112222447869 2175 2842.72727272727 2899 0.00688712839165187 1549 1.50625747638312 -1.10589634841267 -1 1.87628792977866 2175 4001 2105 3606 3575 1549 2250 2899 3795 3036 2279 3038 M10971 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 16/75 Gene Ontology BP GO:0071379 0.0524241978128069 0.0644782915085729 2145 2790 2902 0.00488334142935745 1457 1.02357126628937 1.02357126628937 1 1.44363242349868 1457 3436 1790 3193 3529 2142 2086 2902 4180 3832 2143 3039 M11308 GO_REGULATION_OF_HEAT_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEAT_GENERATION.html Any process that modulates the rate or extent of heat generation. 5/18 Gene Ontology BP GO:0031650 0.000806723262860537 0.00123211056232285 2965 2618.54545454545 2902 8.07016273668359e-05 731 3.34370367453158 -2.83367012658679 -1 11.5239625752339 2961 2417 3727 1259 2902 3459 3903 2089 731 1967 3389 3040 M12966 GO_PHOTORECEPTOR_CELL_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_MAINTENANCE.html Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. 17/52 Gene Ontology BP GO:0045494 0.0612588447894799 0.074730640135984 4525 3170.45454545455 2902 0.00573038180687416 1796 1.99908625650298 -2.51732976667052 -1 2.66772499352315 4524 2555 2544 2902 4375 4436 3018 1796 2567 3465 2693 3041 M15781 GO_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 23/56 Gene Ontology BP GO:0046686 4.53180727458144e-05 8.99964977582619e-05 4575 2887.45454545455 2902 4.11990966230322e-06 1414 1.87864251043327 -1.87598342378633 -1 9.00375827751168 4571 3005 1922 2211 2216 3605 3755 2297 1414 2902 3864 3042 M11379 GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY.html The initiation of the activity of the inactive enzyme JUN kinase (JNK). 17/58 Gene Ontology BP GO:0007257 1.16931208438434e-06 4.92213599981548e-06 3610 2888.45454545455 2905 1.06301155080054e-07 1004 1.16693830162497 -1.3143627872217 -1 7.33743458841261 3609 2156 2523 2866 1004 3129 3516 3721 3502 2905 2842 3043 M11958 GO_MITOTIC_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_ARREST.html The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). 11/18 Gene Ontology BP GO:0071850 0.00167776757326464 0.00244120176830702 1870 2594.45454545455 2905 0.00015264076753196 971 1.414092213786 -1.414092213786 -1 4.37617549335773 1869 3668 2905 3752 3025 971 1538 2117 4029 3650 1015 3044 M13338 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleotide across a membrane. 7/13 Gene Ontology BP GO:1901679 0.000817931878333453 0.00124676878237105 3860 2774.09090909091 2905 8.18233090030819e-05 943 0.893302765385179 -0.674246138008462 -1 3.07330150848348 3857 943 4054 2071 2905 3848 2163 3159 1676 2386 3453 3045 M13701 GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of B cell apoptotic process. 13/27 Gene Ontology BP GO:0002902 0.0803891000102695 0.0949861682962873 2045 2875.09090909091 2905 0.00758965502282995 1857 1.51990194700967 1.86527741673595 1 1.84072314395886 2042 3806 2575 3118 3935 2905 2681 2195 3337 3175 1857 3046 M15297 GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 224/577 Gene Ontology BP GO:0051090 3.57554549202973e-06 1.07940557343915e-05 2945 2806.63636363636 2905 3.25050118471904e-07 1356 1.40502981303805 1.51474445888685 1 8.2668787322276 2942 2905 1985 2417 1440 4540 3439 3291 2780 1356 3778 3047 M15240 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. 10/24 Gene Ontology BP GO:0061081 0.0107137090552547 0.0141406333467981 2875 2749.54545454545 2906 0.000978749264691057 1377 2.18136828422603 2.50424355331758 1 4.77934730299753 2874 3225 1703 1377 3309 4002 2906 3900 1925 2085 2939 3048 M12736 GO_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION.html The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 64/184 Gene Ontology BP GO:0042113 9.66082387535936e-07 4.29236413907115e-06 3830 2563.45454545455 2907 8.78257101609427e-08 935 1.53677229474024 -1.01695107980276 -1 9.77110540526854 3827 2907 1643 2338 935 1007 3521 3669 1771 3162 3418 3049 M13553 GO_POSITIVE_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINESIS.html Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. 17/66 Gene Ontology BP GO:0032467 0.0174037574283536 0.0225210829821198 2650 2784.09090909091 2908 0.00159481631040187 1440 1.54475853873449 -1.54475853873449 -1 3.01467399019588 2646 3771 2427 3514 3654 2654 2988 1440 3127 2908 1496 3050 M11074 GO_CELLULAR_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. 27/63 Gene Ontology BP GO:0006879 4.55944636273395e-06 1.3043326921893e-05 4315 2997.63636363636 2909 4.14495982918436e-07 1525 1.6248606767328 -1.57945239279637 -1 9.40208538079121 4315 2345 2531 2909 1525 3345 3131 4015 2216 2281 4361 3051 M15467 GO_NEGATIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSSIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. 42/94 Gene Ontology BP GO:0030279 1.94382878570622e-05 4.34326454117909e-05 3345 2716 2909 1.76713269162172e-06 1276 1.68839890511819 1.5265923888655 1 8.72483117569895 3342 2909 1276 2108 1958 4197 3707 3107 1842 1456 3974 3052 M12033 GO_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_MEDIATED_IMMUNITY.html Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 29/269 Gene Ontology BP GO:0019724 0.000109593426464438 0.000196844208539415 4470 3170.09090909091 2910 9.96353511481811e-06 2397 1.13668290179149 1.1521657294846 1 4.99008938907702 4466 2397 2539 2910 2458 3092 4112 2876 3189 2890 3942 3053 M12719 GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-beta production. 27/71 Gene Ontology BP GO:0032728 4.31188047916538e-06 1.25047227137819e-05 3830 2806.63636363636 2911 3.91989902749095e-07 1509 1.01897529968693 -1.17869542022227 -1 5.91829988701729 3829 2911 2841 3002 1509 2796 4095 1609 2972 3218 2091 3054 M14441 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION.html The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. 14/26 Gene Ontology BP GO:0015949 0.215176287306448 0.235683770220297 1600 3036.72727272727 2912 0.0217861020439154 1600 0.833747842721598 -0.891519747755174 -1 0.619930840005136 1600 3374 2876 3868 3746 2388 2523 2912 3859 3782 2476 3055 M11635 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 22/31 Gene Ontology BP GO:1902230 2.82177258193567e-06 9.0576367324632e-06 3600 3103.63636363636 2913 2.56525109201375e-07 1353 1.84405461285218 -2.06089593337604 -1 11.0163949959666 3598 2913 2204 2594 1353 4277 4313 3943 2022 2861 4062 3056 M10114 GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 8/25 Gene Ontology BP GO:0090185 2.68888504846459e-06 8.75490412343695e-06 3850 2273.72727272727 2914 2.68888830201639e-07 27 2.82988169894174 -2.12105604774936 -1 16.9552258126231 3848 173 3535 220 1370 4497 3668 2914 27 1724 3035 3057 M12198 GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 18/38 Gene Ontology BP GO:0044275 0.017776938275453 0.0229783753933542 2275 2915.45454545455 2914 0.00162929362041481 1448 1.17244969415476 1.5554000737346 1 2.27596894444322 2272 3288 2914 3629 4087 3181 2621 1448 2558 3546 2526 3058 M14516 GO_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPOLYMERIZATION.html The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. 21/40 Gene Ontology BP GO:0051261 2.66913758950913e-05 5.69260717872803e-05 4155 3115.72727272727 2914 2.42651815747311e-06 1468 1.6069299721348 -1.48598943054381 -1 8.08017591914028 4155 2914 1468 2033 2048 4555 4134 3806 2884 2219 4057 3059 M10803 GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. 75/152 Gene Ontology BP GO:0034250 0.000574776142628537 0.000904945958027907 2970 3020.54545454545 2915 5.22660331522686e-05 1542 1.81517725670209 2.21131419001173 1 6.54414383700369 2970 4538 2286 3133 2799 4101 4202 2470 1542 2270 2915 3060 M10865 GO_BETA_AMYLOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). 11/25 Gene Ontology BP GO:0050435 0.0839184282471183 0.0949861682962873 2660 3030.18181818182 2915 0.00793650793650794 2090 1.84447633852012 -1.65206164850895 -1 2.23380911994107 2656 3585 2727 3465 3683 2090 2164 4208 3177 2915 2662 3061 M14293 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. 20/60 Gene Ontology BP GO:0032753 0.0429449597445045 0.0533137561747953 3120 2682.27272727273 2915 0.00398244674710037 1134 1.74979542723492 -1.88876695224312 -1 2.63905434043286 3120 2915 1571 2256 3503 3025 3873 2842 2119 1134 3147 3062 M14475 GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 7/15 Gene Ontology BP GO:0009312 0.000876113103508718 0.00132890987899085 4420 3013.09090909091 2917 8.76458703664411e-05 923 2.36682731781852 -2.59960198182589 -1 8.06509778968326 4417 2176 4242 2393 2917 3827 4380 2193 1045 923 4631 3063 M10838 GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). 9/33 Gene Ontology BP GO:0042744 0.000887455099694558 0.00134479570100582 2750 2974.63636363636 2919 8.87809708469665e-05 1442 1.09205200695698 -1.2367566004661 -1 3.71455168191184 2750 2481 3645 3353 2919 2196 1442 3285 4267 3482 2901 3064 M13075 GO_SOMITOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITOGENESIS.html The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 32/100 Gene Ontology BP GO:0001756 3.81035529535033e-05 7.72216483470605e-05 3595 3024.54545454545 2919 3.46401935593639e-06 1783 2.0800841208394 2.6363799117408 1 10.1330361513243 3593 3856 1783 2919 2168 4412 3413 2585 2410 2711 3420 3065 M11299 GO_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT.html The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. 86/210 Gene Ontology BP GO:0017038 1.36055938763857e-05 3.20014044417725e-05 2925 2737.72727272727 2920 1.23687981991058e-06 659 1.352765951908 -1.36395664825223 -1 7.20301016819688 2924 4368 3286 4051 1853 857 2474 2823 2920 3900 659 3066 M11841 GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 6/17 Gene Ontology BP GO:0060218 0.00105043508958643 0.00156973611874793 2920 2904.54545454545 2920 0.000105093195641648 850 1.55910519621655 1.8275325825292 1 5.17914699059899 2920 2122 3815 3247 4066 3370 2900 850 3763 2179 2718 3067 M13525 GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. 16/23 Gene Ontology BP GO:0006488 0.0426066489163477 0.0529220628460681 1850 2841.09090909091 2921 0.00395044427562711 1264 0.680753325495552 -0.680642001960717 -1 1.02929876096262 1846 2921 3239 4206 3501 1264 1670 2575 3621 4418 1991 3068 M15206 GO_STEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 22/70 Gene Ontology BP GO:0016126 0.000985439798186284 0.00148119034735478 2820 2902.36363636364 2921 8.96255891327313e-05 1843 0.923569834545788 -1.0114492759598 -1 3.09556755121191 2817 1843 2508 3522 2921 2358 2995 2270 3723 3737 3232 3069 M16610 GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. 16/23 Gene Ontology BP GO:0006490 0.0426066489163477 0.0529220628460681 1850 2869.18181818182 2922 0.00395044427562711 1265 0.680753325495552 -0.680642001960717 -1 1.02929876096262 1847 2922 3240 4207 3502 1265 1671 2670 3622 4623 1992 3070 M11842 GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. 11/54 Gene Ontology BP GO:0021522 0.00989303978769388 0.0131313275398121 2205 2880.18181818182 2923 0.000903437206552521 570 1.8492918812679 -2.37680021862279 -1 4.12222582411267 2203 4010 2396 3644 4492 1717 570 4060 3482 2923 2185 3071 M12635 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS.html Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. 35/80 Gene Ontology BP GO:0050690 0.000992022986362217 0.00148915704031031 4645 3283.81818181818 2924 9.02245992275564e-05 2189 1.28124538858453 -1.12684626538379 -1 4.29086840876899 4643 2189 2609 2474 2924 3863 4023 4107 2696 2498 4096 3072 M11241 GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that activates or increases the frequency, rate or extent of viral release from host cell. 8/18 Gene Ontology BP GO:1902188 0.00994219738149751 0.0131852677641511 1145 2530.54545454545 2925 0.000998696078250631 768 0.802214482690516 -0.802214482690516 -1 1.78651016165318 1141 3384 3715 2925 3833 768 1333 1468 4381 3369 1519 3073 M11211 GO_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. 100/263 Gene Ontology BP GO:0042593 0.00100051625367144 0.00150045121634254 1790 2987.09090909091 2926 9.09974144076398e-05 1786 1.36119477219446 1.46047164406824 1 4.55332639160722 1786 4146 2435 4298 2926 3355 2497 2784 3038 3325 2268 3074 M14445 GO_CARBOHYDRATE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. 100/263 Gene Ontology BP GO:0033500 0.00100051625367144 0.00150045121634254 1790 2985.72727272727 2927 9.09974144076398e-05 1787 1.36119477219446 1.46047164406824 1 4.55332639160722 1787 4147 2436 4299 2927 3356 2498 2759 3039 3326 2269 3075 M15279 GO_RESPONSE_TO_HYDROPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROPEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. 13/26 Gene Ontology BP GO:0033194 0.000713156968222391 0.00110042798386725 3395 2903.36363636364 2927 6.48534774332075e-05 1853 1.52959479366743 -1.59471824323743 -1 5.3606430436102 3392 2927 2230 2706 2847 3259 3920 2068 3270 1853 3465 3076 M15543 GO_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. 93/196 Gene Ontology BP GO:0006643 1.03610561713891e-06 4.50856455517898e-06 3825 2991.81818181818 2928 9.41914641000482e-08 958 1.22037804060117 -1.03553484465885 -1 7.72855381227981 3821 1467 2686 3052 958 4434 2430 4333 2928 2574 4227 3077 M12346 GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. 61/127 Gene Ontology BP GO:0006892 2.1843644473001e-06 7.62556701414614e-06 2390 2708.36363636364 2929 1.98578783285739e-07 1240 1.16274115004407 -1.18859298285969 -1 7.04917396703026 2390 3173 3279 3683 1240 1694 3218 2477 2929 3560 2149 3078 M15395 GO_KETONE_BODY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BODY_METABOLIC_PROCESS.html The chemical reactions and pathways involving ketone body. 5/14 Gene Ontology BP GO:1902224 9.44298552852779e-06 2.35466067717264e-05 3905 3052 2930 9.44302565525681e-07 1667 1.60406065952735 -2.08235316346649 -1 8.79425150843409 3904 1667 4396 2856 1765 4247 3603 2930 1702 1988 4514 3079 M15755 GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. 10/24 Gene Ontology BP GO:1904666 6.48951133119092e-05 0.000123234360371041 2480 2744.54545454545 2931 5.89972978660566e-06 1177 1.07086205498801 -1.07086205498801 -1 4.95914662914638 2478 3046 2931 3565 2322 1695 2226 3612 3543 3595 1177 3080 M16593 GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. 417/956 Gene Ontology BP GO:0034622 0.000268672795614381 0.000446633652000562 2210 3154.81818181818 2931 2.44277829655741e-05 2137 1.3891377005211 -1.16675959199143 -1 5.51282706693478 2207 4357 3445 3991 2651 2137 2914 3173 2778 4119 2931 3081 M11476 GO_MALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GAMETE_GENERATION.html Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. 215/832 Gene Ontology BP GO:0048232 2.59929070106911e-07 2.06652512415477e-06 2760 3008.72727272727 2932 2.36299182561296e-08 393 1.44439385548706 -1.12542475679752 -1 9.72692887935597 2757 4359 2932 4163 393 3821 2546 2750 2708 3543 3124 3082 M16084 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. 17/42 Gene Ontology BP GO:0032733 0.000605325576322958 0.000949502246914694 3170 2902.45454545455 2932 5.50447449658379e-05 1803 1.63126485971533 1.52918957916446 1 5.84075974414932 3168 3881 1937 3320 2803 2932 2013 4159 3306 1803 2605 3083 M12390 GO_REGULATION_OF_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEEDING_BEHAVIOR.html Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. 4/30 Gene Ontology BP GO:0060259 0.000956401263826062 0.00144067750554278 3215 2612.36363636364 2935 9.5681312984361e-05 954 1.43392989516485 -0.538262311048561 -1 4.82662239763087 3213 1221 3901 1842 2935 2200 3029 3545 954 2781 3115 3084 M14363 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 8/12 Gene Ontology BP GO:1900102 6.74769865752899e-05 0.000127459580418662 2935 3244.90909090909 2935 6.74790355775281e-06 2360 0.783134428620703 -0.834170778680909 -1 3.61310135356362 2935 2733 4229 3068 2360 2463 2620 4423 3788 4468 2607 3085 M16946 GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 14/50 Gene Ontology BP GO:0010907 0.00151897921672561 0.0022219976380772 2780 2695.09090909091 2935 0.000138184454851713 892 1.72275571758197 1.71959005464004 1 5.41478090047953 2780 3257 2155 1508 2997 3849 2623 2935 892 3252 3398 3086 M10192 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT.html The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/32 Gene Ontology BP GO:0043252 0.0290226920340913 0.0367573265450862 3555 2703.72727272727 2936 0.00294088517216959 808 1.36743551445372 -1.37558340851903 -1 2.32398032336181 2365 2936 3552 3155 3552 2408 808 1795 4003 2167 3000 3087 M13880 GO_RETINAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. 6/26 Gene Ontology BP GO:0042574 0.111667265996541 0.125416331887262 2485 3077.18181818182 2936 0.0117710631052643 2228 1.39967466319699 0.924583904230022 1 1.49499840397569 2484 2848 4151 2861 3660 2663 2228 3110 3767 3141 2936 3088 M14726 GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT.html The directed movement of substances from early endosomes to the Golgi. 11/16 Gene Ontology BP GO:0034498 0.00891607859656734 0.0119129073162193 1365 2485 2936 0.000813856337510839 729 0.925213130615386 -0.925213130615386 -1 2.10872817674887 1365 3609 3107 3747 3788 729 1276 1578 3999 2936 1201 3089 M10932 GO_T_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 25/50 Gene Ontology BP GO:0043029 0.000956431858823434 0.00144067750554278 2915 3195.27272727273 2937 8.69861739032628e-05 2225 0.834938031173342 -0.863165805139576 -1 2.81040907797419 3652 2693 2937 3376 2915 2837 3870 2225 3750 3981 2912 3090 M15673 GO_AXONEME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_ASSEMBLY.html The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 28/98 Gene Ontology BP GO:0035082 0.000533614657672111 0.000844913229294231 3205 2932.63636363636 2937 4.85221937277121e-05 1216 1.34958839370695 -1.99906614359927 -1 4.91324477387106 3201 3366 2660 3127 2779 2937 4352 1216 2580 3680 2361 3091 M14496 GO_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 18/38 Gene Ontology BP GO:0001935 1.06856480748334e-05 2.61812474994467e-05 3020 2702.81818181818 2939 9.71427270598542e-07 1426 1.16160988081263 -1.27231615900134 -1 6.30513346743311 3020 1850 1426 2948 1774 2939 3187 2772 3481 3549 2785 3092 M14569 GO_REGULATION_OF_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_ORGANIZATION.html Any process that modulates the frequency, rate or extent of chromatin organization. 88/225 Gene Ontology BP GO:1902275 0.000486855597618913 0.000775195658348632 3315 3048.90909090909 2939 4.42693973800008e-05 2143 1.61309317378127 1.63645880146866 1 5.94401665608352 2549 4366 2496 3284 2765 3315 2143 2939 2805 3561 3315 3093 M14255 GO_CELLULAR_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCOSE_HOMEOSTASIS.html A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. 49/105 Gene Ontology BP GO:0001678 6.83836990645807e-06 1.79991788410912e-05 1830 2777.63636363636 2941 6.21671923872489e-07 1658 1.19218079128421 1.23768201499412 1 6.70090098686811 1826 2685 2392 3573 1658 2941 3009 3370 3121 3349 2630 3094 M14522 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 26/45 Gene Ontology BP GO:1902042 2.68972699298334e-05 5.72801614688366e-05 4620 2860.81818181818 2943 2.44523625293994e-06 1394 1.23432902722532 -0.96291077354908 -1 6.20267686759872 4620 1400 1620 1394 2051 3088 4204 3666 2943 2210 4273 3095 M15292 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that modulates the frequency, rate or extent of protein localization to nucleus. 158/363 Gene Ontology BP GO:1900180 3.08182311769159e-06 9.6812616613275e-06 3465 3047.45454545455 2943 2.80166130436936e-07 1385 1.41252801197436 -1.21189000978585 -1 8.3900646407357 3462 2943 2772 2656 1385 4161 3518 2666 2194 3688 4077 3096 M16283 GO_MYELOID_DENDRITIC_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_ACTIVATION.html The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 14/33 Gene Ontology BP GO:0001773 0.00733819511743845 0.00989888883206686 4445 3202.54545454545 2943 0.000669344263559972 1225 1.28399029006464 -1.35564187073508 -1 3.0487859345842 4445 2812 2802 2682 3778 4464 2943 1225 3420 2629 4028 3097 M13233 GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 35/75 Gene Ontology BP GO:0009142 0.0113032587225851 0.014862936915594 1460 2768.54545454545 2945 0.0010328867550132 1460 1.01886541975793 -1.18760270197291 -1 2.20620530676705 1460 3595 3301 3497 3317 1914 2024 1983 2945 3970 2448 3098 M16761 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 15/43 Gene Ontology BP GO:1902175 5.92480672979669e-05 0.000113767070498123 4080 3051.63636363636 2945 5.38633299675052e-06 1509 1.08189271246371 -0.839557288373457 -1 5.05472151665009 4078 1563 2945 1509 2294 4602 3988 2296 2407 3343 4543 3099 M11286 GO_PROTEIN_NEDDYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_NEDDYLATION.html Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. 7/16 Gene Ontology BP GO:0045116 0.0511038452252857 0.0629210165422969 2540 3061.81818181818 2946 0.0052318571421184 2375 1.00823610358536 1.07061941509854 1 1.4346854856068 2539 3562 3725 3291 3542 2846 2946 2814 2676 2375 3364 3100 M12045 GO_LIPID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. 58/179 Gene Ontology BP GO:0055088 6.13872578477334e-07 3.23212152206309e-06 3710 2955.09090909091 2947 5.5806613615282e-08 749 1.60747376637191 1.77633087753566 1 10.4552590104782 3706 2947 1263 2169 749 4043 4495 4330 2860 1889 4055 3101 M12394 GO_PROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. 656/1551 Gene Ontology BP GO:0070271 1.02944092064978e-06 4.49016470728422e-06 4615 3013.45454545455 2947 1.02944139753696e-07 990 1.56032659817097 -1.35168076988922 -1 9.88470332945318 4611 1670 3903 2308 990 2947 4623 4474 1907 1578 4137 3102 M16252 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. 59/208 Gene Ontology BP GO:1902106 0.0839184282471183 0.0949861682962873 2300 3039.36363636364 2947 0.00793650793650794 1645 1.48497609704778 -1.67219695683185 -1 1.79842510018718 2298 4374 2490 4126 3848 1645 2947 2432 3381 3522 2370 3103 M13781 GO_CELLULAR_RESPONSE_TO_CHOLESTEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CHOLESTEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. 11/28 Gene Ontology BP GO:0071397 0.00111154454015325 0.00165519605514162 3565 2935.90909090909 2948 0.00010110059480404 1356 1.39281892543757 1.04805180642312 1 4.58877857343183 3561 1356 2274 2410 2948 4259 2702 3765 3334 2238 3448 3104 M14936 GO_POSITIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 231/537 Gene Ontology BP GO:0045862 2.0170404650381e-06 7.18735140381572e-06 4065 2923.18181818182 2948 1.8336748312154e-07 1213 1.60009207628541 -1.3104371436519 -1 9.7493560130701 4063 3359 1848 3090 1213 2695 3817 2948 2149 2428 4545 3105 M16814 GO_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex. 656/1551 Gene Ontology BP GO:0006461 1.02944092064978e-06 4.49016470728422e-06 4625 3081.09090909091 2948 1.02944139753696e-07 991 1.56032659817097 -1.35168076988922 -1 9.88470332945318 4612 1671 4621 2309 991 2948 4624 4491 1908 1579 4138 3106 M10346 GO_LUNG_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_EPITHELIUM_DEVELOPMENT.html The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. 18/43 Gene Ontology BP GO:0060428 7.71427352277657e-07 3.69251257384037e-06 3060 2463.54545454545 2949 7.01297838888966e-08 854 2.20891583824586 -2.25739416635176 -1 14.2157960966394 3056 3094 1418 2001 854 2989 3407 3555 1905 1871 2949 3107 M14915 GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. 52/123 Gene Ontology BP GO:1904029 4.84834004801536e-06 1.36844029440336e-05 4465 2893.18181818182 2949 4.40759157525104e-07 1549 1.38737570434649 -1.23873190094073 -1 7.99365674024963 4461 3731 2275 3582 1549 1878 1945 2698 2949 3191 3566 3108 M15560 GO_EPITHELIAL_STRUCTURE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_STRUCTURE_MAINTENANCE.html A tissue homeostatic process required for the maintenance of epithelial structure. 13/49 Gene Ontology BP GO:0010669 0.0839184282471183 0.0949861682962873 2280 3051.45454545455 2950 0.00793650793650794 2175 1.90989839423308 1.90989839423308 1 2.31304054821555 2280 4194 2175 3584 3628 2853 2236 3318 2950 3760 2588 3109 M13042 GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. 11/21 Gene Ontology BP GO:0009200 5.46376102394111e-05 0.000105762235883329 2730 3105.90909090909 2952 4.96717883879988e-06 2111 0.681041621871285 -0.694778945198304 -1 3.20746398901385 2727 2111 2952 3682 2273 3003 2928 3533 3751 4375 2830 3110 M10121 GO_HEMOGLOBIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. 7/15 Gene Ontology BP GO:0020027 0.00227263650608334 0.00324772277554477 2750 2860.90909090909 2953 0.000227496405141288 1518 1.46483242616452 1.46483242616452 1 4.31807065195089 2748 1518 3538 2290 3094 3610 2953 3029 2656 3267 2767 3111 M11697 GO_ORGAN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. 11/46 Gene Ontology BP GO:0048799 0.0839184282471183 0.0949861682962873 2950 2984.09090909091 2953 0.00793650793650794 1656 1.67625062738142 -1.60492702207648 -1 2.03007410701992 2946 2441 1656 2957 3992 2953 2866 4291 3060 2229 3434 3112 M10251 GO_REGULATION_OF_VESICLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_FUSION.html Any process that modulates the frequency, rate or extent of vesicle fusion. 31/71 Gene Ontology BP GO:0031338 0.00152980562786555 0.00223572160219696 2955 2920.45454545455 2955 0.000139170039975948 2180 0.976707985375664 -1.00062281968797 -1 3.06678896348714 2350 3033 2955 3860 3000 2180 2955 2605 3472 3441 2274 3113 M12925 GO_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. 407/922 Gene Ontology BP GO:0043603 0.00121827679275202 0.00180544498842886 1085 2583.45454545455 2955 0.000110813813804493 632 1.19667201394204 -1.07934065008507 -1 3.88906027675855 1084 4218 3508 4573 2955 632 957 1921 3138 4146 1286 3114 M14980 GO_VACUOLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_FUSION.html Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. 17/25 Gene Ontology BP GO:0097576 0.0018163999611406 0.00262481948944159 1040 2405.18181818182 2955 0.000165263762066702 765 0.760343429340782 -0.760343429340782 -1 2.32465686003595 1036 2955 3351 3276 3038 765 1045 1381 3738 4511 1361 3115 M16045 GO_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 667/1589 Gene Ontology BP GO:0033043 2.23767946063026e-07 1.920433592552e-06 2330 3126 2955 2.23767968595472e-08 372 1.51554410611161 1.76005164320549 1 10.2632396286215 2328 4459 4500 4266 372 4154 2610 2155 2614 3973 2955 3116 M15582 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. 12/19 Gene Ontology BP GO:0097296 0.00136301152639556 0.00200712417286856 3225 2870.63636363636 2958 0.000123986974028617 1806 1.3975891105176 1.54566373604572 1 4.46587894529231 3225 2958 2455 1806 2975 4153 3561 2646 1820 3058 2920 3117 M13316 GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 8/43 Gene Ontology BP GO:2000516 0.0047326636112903 0.00653591824723999 3020 2779.45454545455 2959 0.00047427730732873 1055 1.62788614796114 -1.78437778054164 -1 4.21300961617679 3016 2172 4051 2408 3210 2959 2185 2706 3251 1055 3561 3118 M16057 GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT.html The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. 6/21 Gene Ontology BP GO:0060525 0.00114730942446625 0.00170462645049498 4640 2914 2959 0.000114790219875071 40 3.02143346449281 -1.7527656154046 -1 9.90866895715396 4639 2485 4502 1232 2959 4577 4158 1815 40 1316 4331 3119 M16160 GO_PROTEIN_INSERTION_INTO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_INSERTION_INTO_MEMBRANE.html The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. 11/30 Gene Ontology BP GO:0051205 0.0233317771926598 0.0297690138789556 3670 2944 2960 0.00214390512018452 1110 3.50771827534608 3.50771827534608 1 6.341971084072 3666 2639 2607 2960 3409 2382 2504 3607 1110 3662 3838 3120 M13851 GO_METHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 9/21 Gene Ontology BP GO:0006555 0.0376155559290882 0.0470118509229492 1800 3010.27272727273 2961 0.00382678693050203 1800 1.39967310273171 1.39967310273171 1 2.20158089089002 1800 2961 4144 3294 3493 2838 2502 2868 3152 2690 3371 3121 M12625 GO_COBALAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COBALAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. 9/42 Gene Ontology BP GO:0009235 0.0304519514011887 0.0385149578740722 2730 2971.72727272727 2962 0.00308774760583322 1677 1.21225593871225 1.17932784838484 1 2.03111855831495 2726 2706 3939 3450 3452 2962 1677 2272 3843 1912 3750 3122 M14167 GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 8/18 Gene Ontology BP GO:0060391 0.0765897756730953 0.0916038970762961 3315 2963.09090909091 2964 0.00793650793650794 1255 1.33994369693032 -0.844863202292802 -1 1.64777368717988 3314 2964 4196 1966 3679 4039 2539 2567 1255 3399 2676 3123 M14368 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex assembly. 115/268 Gene Ontology BP GO:0031334 3.00044542500308e-07 2.22656515827802e-06 3910 2689.45454545455 2965 2.72767803110505e-08 436 1.49082100267024 1.64109080064583 1 9.98237080391187 3909 2087 2188 1067 436 3346 3962 3913 1280 2965 4431 3124 M15477 GO_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of organelle assembly. 91/202 Gene Ontology BP GO:1902115 0.00128815830679597 0.00190535808169916 2755 2849.63636363636 2965 0.000117173925135635 1330 1.23697932781683 -1.17671529132964 -1 3.98577702507044 2751 3760 3120 3958 2965 1330 2325 2316 3017 3873 1931 3125 M10178 GO_ETHER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHER_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. 5/13 Gene Ontology BP GO:0018904 0.0214772433669346 0.027508645780049 2075 2664 2966 0.00216876839251869 1599 1.17188251977645 -1.17188251977645 -1 2.16637772901002 2071 3130 3550 3213 3412 1762 1599 1890 3691 2966 2020 3126 M14299 GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. 7/22 Gene Ontology BP GO:0006577 0.00118640157762624 0.00175989218048518 1745 2582.36363636364 2967 0.000118703545087914 1018 1.41318974561356 -1.41318974561356 -1 4.61130018862151 1744 3266 4221 3150 2967 1018 1610 2565 3181 3290 1394 3127 M14758 GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. 21/55 Gene Ontology BP GO:0060338 0.000748389048029842 0.00115058620861012 2735 2712.36363636364 2967 6.80585230875129e-05 777 1.04294644913038 -1.13961545750938 -1 3.63121063206855 2732 2348 3151 3326 3598 1808 2967 777 3464 3941 1724 3128 M15578 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. 9/31 Gene Ontology BP GO:2000353 2.29495615084023e-05 5.01670499451563e-05 3480 3032.09090909091 2967 2.29497985189152e-06 1866 1.82645904047988 -1.44098916006038 -1 9.30280975585378 3478 1866 4427 1910 2026 4609 3986 2967 2031 1924 4129 3129 M11432 GO_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 28/50 Gene Ontology BP GO:0044088 1.55494303052758e-05 3.59721001033362e-05 3365 2990 2968 1.41359456441249e-06 1885 1.14138646871166 -1.0180880207128 -1 6.00880475821955 3365 2808 2968 3635 1885 2517 3063 3908 2792 2869 3080 3130 M12953 GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION.html Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 10/19 Gene Ontology BP GO:0051127 0.000778118439518679 0.00119155801935529 4500 3124.81818181818 2968 7.07630717034821e-05 788 1.5840808191938 -2.58373837981968 -1 5.48675492811199 4499 2283 2603 2767 2968 4626 3881 788 2431 3581 3946 3131 M10851 GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a sphingolipid. 5/14 Gene Ontology BP GO:0090520 0.148198341859106 0.165166802988917 1890 3034 2969 0.0159121992306046 1887 1.49863107644468 -1.49863107644468 -1 1.38842349931253 1887 4020 3648 4003 3816 1962 2287 2154 4056 2969 2572 3132 M11969 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. 268/647 Gene Ontology BP GO:0055086 1.15552595177199e-05 2.79869952742689e-05 2245 2927.90909090909 2969 1.0504836555367e-06 1792 1.28227932769105 -1.04887882689117 -1 6.91611901251735 2242 3872 3145 3891 1792 2040 2232 3316 2969 3951 2757 3133 M14883 GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. 14/44 Gene Ontology BP GO:0038083 0.00131059638956409 0.00193726258076382 3795 3022.18181818182 2969 0.000119216163382741 2019 1.19895116839352 -1.0803114252794 -1 3.85300015763007 3791 2703 2397 2019 2969 2287 3492 4395 3321 3245 2625 3134 M11034 GO_C21_STEROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 11/43 Gene Ontology BP GO:0008207 4.81054842828539e-06 1.36108326340823e-05 3970 2942.36363636364 2971 4.37323540647723e-07 1181 1.40727359443355 -0.767010613240216 -1 8.11220554336771 3966 2320 2296 2127 1544 2971 3264 4536 1181 3643 4518 3135 M14180 GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 42/97 Gene Ontology BP GO:0009124 0.00133033134507331 0.00196211195526537 1735 2784.63636363636 2971 0.000121012406626113 1733 1.01081275079307 -1.08882173078368 -1 3.24176221483852 1733 3708 3036 3601 2971 1946 1944 1860 3548 3823 2461 3136 M13563 GO_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENTATION.html The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. 48/137 Gene Ontology BP GO:0035282 0.000296739561939612 0.000488914757305046 2965 2972.45454545455 2972 2.69799631101669e-05 1711 1.82467831922241 2.27138525784306 1 7.15637203536385 2962 3761 1711 3274 2669 4000 2774 2285 2982 3307 2972 3137 M13835 GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. 34/76 Gene Ontology BP GO:0030433 0.000119851414628508 0.000213862458923967 770 2288.81818181818 2972 1.08961767619817e-05 182 0.926741046648611 -0.926741046648611 -1 4.02889974391619 770 3855 3334 3545 2972 182 773 1218 4067 4043 418 3138 M14885 GO_LATERAL_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. 14/49 Gene Ontology BP GO:0021670 0.000639276952868972 0.00099502611202502 3325 2656.45454545455 2972 5.81329808952766e-05 749 2.61231367793399 3.40734530510536 1 9.29047631499893 3324 3803 1895 2972 3850 3424 2026 749 1150 3246 2782 3139 M13587 GO_GOLGI_TO_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_ENDOSOME_TRANSPORT.html The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. 14/27 Gene Ontology BP GO:0006895 0.000759251346243774 0.00116535669441648 2975 3118.36363636364 2973 6.90466819430003e-05 1861 0.992286255454924 -1.03919669305883 -1 3.44831591495206 2973 4245 2973 3862 2867 2488 4160 1861 3242 3243 2388 3140 M12130 GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS.html Any process that modulates the frequency, rate or extent of removal of superoxide radicals. 4/10 Gene Ontology BP GO:2000121 3.40843566185509e-08 5.77568130583692e-07 4500 2186.54545454545 2974 3.40843571413354e-09 27 2.78236600614157 -1.67772597354963 -1 20.5619982746596 4498 347 3855 106 27 3451 2974 3441 42 1698 3613 3141 M13890 GO_OOCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. 13/45 Gene Ontology BP GO:0001556 0.0816203741121495 0.0949861682962873 3960 2948 2974 0.00771052367694382 1785 1.64282089870569 -1.8221300243814 -1 1.98958798776027 3957 3222 2160 2772 3594 2974 1785 2467 2072 3178 4247 3142 M11179 GO_BONE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 14/29 Gene Ontology BP GO:0098751 2.44516769487589e-05 5.29273361646096e-05 2010 2790.09090909091 2975 2.22290442897019e-06 1227 1.0002304368538 1.0002304368538 1 5.06696863587373 2010 3774 2975 3363 2016 2619 3001 1227 3453 3778 2475 3143 M14589 GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that activates or increases the frequency, rate or extent of protein acetylation. 22/48 Gene Ontology BP GO:1901985 0.00309551237990604 0.00434870317092397 3010 2877.09090909091 2976 0.000281806956652138 1488 1.6011399364382 -1.82158883239766 -1 4.47941157479977 3007 2976 1488 2582 3132 2840 3111 3688 2744 2864 3216 3144 M15126 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. 22/42 Gene Ontology BP GO:1901797 2.06825989496489e-05 4.57718336144995e-05 3890 3041 2976 1.88025394482468e-06 1976 1.36642656411616 -1.32301708782161 -1 7.02415599179397 3889 3092 2781 3126 1976 2705 4385 2590 2976 3736 2195 3145 M12255 GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 11/18 Gene Ontology BP GO:0042559 0.00056131430911768 0.000885252152592864 2980 3116.81818181818 2977 5.1041597785241e-05 2281 1.02550960983942 -0.68231073843308 -1 3.70881280465992 2977 2281 2988 2862 2794 2818 3473 4315 3149 3651 2977 3146 M13902 GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of erythrocyte differentiation. 27/48 Gene Ontology BP GO:0045646 0.0508542724463847 0.0626635846519544 2320 3039.72727272727 2978 0.00473357326105345 1743 1.13899211094361 1.26061127352475 1 1.62314939811911 2318 3711 2226 3599 4347 3057 2978 1743 3903 2748 2807 3147 M15079 GO_PROTEIN_K63_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. 23/59 Gene Ontology BP GO:0070534 0.278103752238187 0.300987347702075 2645 3186.90909090909 2978 0.0291903797788131 2136 0.97569088002597 -0.97569088002597 -1 0.60270288876618 2645 4062 2978 4218 3964 2390 2136 2403 4108 3776 2376 3148 M10477 GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of ERBB signaling pathway. 53/115 Gene Ontology BP GO:1901184 0.000107073009491144 0.000192989123861562 2945 2970 2981 9.73438373103759e-06 2229 1.56615645312229 -1.36136724209863 -1 6.89143499061491 2945 3204 2229 2981 2448 3826 2357 3268 3178 3730 2504 3149 M12680 GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING.html Any process that activates or increases the frequency, rate or extent of telomere capping. 5/20 Gene Ontology BP GO:1904355 0.00111854444862847 0.00166508556427765 1765 2542.54545454545 2983 0.000111910786155521 526 1.58206462825643 -1.58206462825643 -1 5.20741871793931 1761 3453 3947 3866 4194 688 526 1616 4157 2983 777 3150 M14104 GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. 8/18 Gene Ontology BP GO:0042754 2.85034089910208e-05 5.99371956274047e-05 1330 2421.81818181818 2983 2.85037745975667e-06 310 1.15253363897655 -1.15253363897655 -1 5.76475746737002 1328 3644 4188 3480 2983 866 1518 310 3736 3398 1189 3151 M16327 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. 15/37 Gene Ontology BP GO:0000083 0.456475820820603 0.48477063954027 1470 3135 2983 0.0539175461658129 1468 1.11856051663819 -1.11856051663819 -1 0.416683537371533 1468 4005 2563 3708 4482 2379 2289 2983 4145 3813 2650 3152 M14920 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 12/24 Gene Ontology BP GO:0042347 0.0839184282471183 0.0949861682962873 4415 2893.27272727273 2985 0.00793650793650794 85 1.83495767434592 -0.782728208686081 -1 2.22228124375975 4411 2231 2329 1589 4277 3431 2907 2985 85 3057 4524 3153 M15684 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. 8/30 Gene Ontology BP GO:0060850 0.44554161662476 0.473808915709748 2040 3223.18181818182 2985 0.057270938159753 1759 1.50510028069092 -1.50510028069092 -1 0.578387367214218 2036 2962 4440 2985 4460 2605 3260 4151 4113 1759 2684 3154 M13372 GO_PHOSPHATE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSPORT.html The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/20 Gene Ontology BP GO:0006817 5.86514279873451e-06 1.5962402118713e-05 1400 2414.63636363636 2986 5.86515827874703e-07 165 1.17093909090952 1.17093909090952 1 6.6538517487399 1399 3871 4062 3340 3158 1642 1079 165 3290 2986 1569 3155 M14530 GO_STRAND_DISPLACEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRAND_DISPLACEMENT.html The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. 13/27 Gene Ontology BP GO:0000732 0.562127744549986 0.590889544474889 1675 3269.90909090909 2986 0.0723263503384565 1672 0.517174830436356 -0.517174830436356 -1 0.139985961617136 1672 4013 2986 4121 4168 2306 2069 2762 4477 4485 2910 3156 M11035 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. 13/36 Gene Ontology BP GO:0045686 4.09310568094596e-05 8.21274402620228e-05 4040 2921.90909090909 2987 3.72107439569677e-06 648 2.00662686655887 -1.12473846783931 -1 9.71160721481848 4036 2987 2050 2261 2189 3829 3825 4393 648 2469 3454 3157 M13562 GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 5/12 Gene Ontology BP GO:0060394 0.0405903234122322 0.0505257028426258 1290 2753.27272727273 2987 0.00413513706621613 895 1.0703790870276 1.0703790870276 1 1.64393125424904 1288 3564 4097 3689 4399 1270 895 2302 3971 2987 1824 3158 M11944 GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION.html The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. 6/13 Gene Ontology BP GO:0017187 0.000621069394473309 0.000970264198701068 2990 2867.72727272727 2989 6.2124304001636e-05 1018 1.79094718516443 -2.2238940733183 -1 6.39257382160852 2989 2872 3830 3021 2833 3559 3725 2385 1018 2180 3133 3159 M14384 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that increases the amount of sodium excreted in urine over a unit of time. 5/17 Gene Ontology BP GO:0035815 0.0765897756730953 0.0916038970762961 2105 2961.36363636364 2989 0.00793650793650794 2057 3.22360039544141 3.22360039544141 1 3.96417184510806 2102 2940 4232 2684 3646 2835 2057 2989 3090 2995 3005 3160 M13040 GO_PROTEIN_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CARBOXYLATION.html The addition of a carboxy group to a protein amino acid. 6/13 Gene Ontology BP GO:0018214 0.000621069394473309 0.000970264198701068 2990 2884.81818181818 2990 6.2124304001636e-05 1019 1.79094718516443 -2.2238940733183 -1 6.39257382160852 2990 2873 3998 3022 2834 3560 3726 2391 1019 2186 3134 3161 M13066 GO_MIDDLE_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDDLE_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). 9/30 Gene Ontology BP GO:0042474 0.000802855661403236 0.00122660705360159 2115 3090 2990 8.03145868723212e-05 2023 1.46988684754035 1.46988684754035 1 5.06930016628878 2114 2963 4006 2768 2899 3002 2990 4463 3267 3495 2023 3162 M10846 GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 66/144 Gene Ontology BP GO:0071482 0.000109377382727203 0.000196552833646017 2315 2928.18181818182 2991 9.94389282001916e-06 1930 1.48133184900941 1.97969723744807 1 6.50424330434978 2314 3730 1993 3719 2456 4056 2688 1930 2991 3232 3101 3163 M15344 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. 7/31 Gene Ontology BP GO:0035235 0.000338764249795098 0.000551694988354486 4535 3227.45454545455 2991 3.38815903425387e-05 1126 1.39201878429626 -1.27162823274289 -1 5.37296804993467 4534 1126 4392 1886 2717 4558 2991 4251 2610 2399 4038 3164 M16175 GO_IMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. 4/11 Gene Ontology BP GO:0006188 0.0148441657195801 0.0193219684429522 1610 2896.18181818182 2992 0.00149442652415018 1046 0.933350721334644 0.933350721334644 1 1.89504874423129 1608 3393 4524 2992 3362 1827 1046 3399 4146 2799 2762 3165 M15986 GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. 4/14 Gene Ontology BP GO:0003417 0.00306755607965396 0.00431595844782828 1550 2661.72727272727 2993 0.000307179877976764 1480 1.01028941045369 1.01028941045369 1 2.83035299250823 1546 3131 4492 2993 3148 1610 1480 3788 3669 1713 1709 3166 M10787 GO_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_PROLIFERATION.html The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. 6/25 Gene Ontology BP GO:0043616 5.7443634195931e-05 0.000110714318626695 2790 2689.54545454545 2995 5.74451191469545e-06 148 5.55876916266923 5.55876916266923 1 26.048974049019 2789 3354 3634 2995 3974 3583 2734 403 148 3112 2859 3167 M12418 GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of mast cell degranulation. 6/16 Gene Ontology BP GO:0043306 3.07124863849673e-06 9.65457510395417e-06 3350 2751.09090909091 2996 3.07125288316067e-07 802 1.53432697482883 1.53432697482883 1 9.11569920898129 3348 1128 3905 1880 1413 4384 4537 2996 802 3124 2745 3168 M14535 GO_PIRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. 5/15 Gene Ontology BP GO:0034587 0.0329209878149613 0.0414682979991495 2555 2777.72727272727 2996 0.00334191117226088 531 3.12144353544104 3.12144353544104 1 5.11129158421312 2554 3451 4249 2267 3967 3238 3287 1643 531 2996 2372 3169 M11659 GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 17/33 Gene Ontology BP GO:0046134 0.521786036803985 0.550477747984754 4285 3182.36363636364 2997 0.0648640562708822 1844 0.749274036769661 -0.793694991344058 -1 0.230118490712735 1844 3340 2634 4284 4016 2217 2328 2997 4272 4281 2793 3170 M10045 GO_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_RHYTHM.html Any biological process in an organism that recurs with a regularity of approximately 24 hours. 68/192 Gene Ontology BP GO:0007623 2.11164981435091e-06 7.43883921701919e-06 3945 2683.54545454545 2998 1.91968349200122e-07 897 1.96039889650216 2.34384377330592 1 11.9100178285237 3945 3086 897 2216 1229 2998 4473 4321 1636 1280 3438 3171 M16510 GO_ERYTHROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. 16/33 Gene Ontology BP GO:0048821 0.161385165508919 0.178875942577683 1940 3109.18181818182 2998 0.0158730158730159 1936 1.23743965085336 1.23743965085336 1 1.09567684732148 1936 3372 2640 4286 4179 2716 2101 2421 3708 3844 2998 3172 M13481 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE.html The directed movement of a protein to a specific location in a membrane. 163/432 Gene Ontology BP GO:0090150 0.0207572776735486 0.0266232155354382 3125 2831.90909090909 3000 0.00190506835375947 900 1.56706032399836 -1.46974020789418 -1 2.92329259051227 3122 4024 3421 2933 3814 900 2575 3000 1710 3934 1718 3173 M14974 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. 5/20 Gene Ontology BP GO:0032691 0.000290008424755424 0.000478673699303033 1950 2770.18181818182 3000 2.9004627890725e-05 618 1.03312111304555 -1.03312111304555 -1 4.06314262129878 1950 3198 4326 3569 3443 1895 2887 618 4016 3000 1570 3174 M12597 GO_DNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS.html The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 15/30 Gene Ontology BP GO:0006308 0.0729773436244524 0.0885608485228261 1855 3080.27272727273 3003 0.0068651693299749 1829 0.870180101639344 -0.870180101639344 -1 1.08521358660069 2265 4299 3003 4522 4402 1904 1829 1851 4148 3808 1852 3175 M11994 GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of an acute inflammatory response. 27/97 Gene Ontology BP GO:0002673 0.00754990209264279 0.0101694793780506 2230 2938.63636363636 3004 0.000688721528864666 1606 1.65498705466755 1.56029375048019 1 3.90674185652535 2229 3004 1606 4210 3269 3330 2149 2387 3689 2746 3706 3176 M12409 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 16/44 Gene Ontology BP GO:0033144 6.56783210317255e-05 0.000124510835070255 4380 3355.81818181818 3005 5.97093471454332e-06 2327 1.23141459183515 -1.24537713610576 -1 5.69613493696889 4380 2701 2593 2444 2327 3005 4519 4149 3530 2850 4416 3177 M14267 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. 9/21 Gene Ontology BP GO:0071636 0.00472660012419848 0.0065294865744283 3005 3160.18181818182 3005 0.000473668365943783 1704 0.932575199878554 1.13560889526878 1 2.41399933056808 3005 2819 4215 2970 3209 3746 2507 1704 4065 2693 3829 3178 M15471 GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 5/14 Gene Ontology BP GO:0003376 0.1496421398535 0.166695886597841 1890 3107.63636363636 3005 0.0160791288055138 1888 1.49863107644468 -1.49863107644468 -1 1.38131851668462 1888 4021 4412 4004 3817 1963 2288 2156 4057 3005 2573 3179 M12610 GO_PROTEIN_HETEROTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTETRAMERIZATION.html The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. 23/43 Gene Ontology BP GO:0051290 0.0198868287857279 0.0255491272972148 1665 3030.45454545455 3006 0.00182444577665679 1665 1.04680941732225 -0.98098093050825 -1 1.97496129922028 1665 3006 2652 3581 3389 2459 3514 3649 3590 2898 2932 3180 M14941 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 22/70 Gene Ontology BP GO:0009948 2.64399335202608e-05 5.64676225090022e-05 2590 3047.09090909091 3007 2.40365920770333e-06 2045 1.25957786160957 1.19056789050123 1 6.3388140333889 2586 2661 2316 3007 2045 4028 3690 2926 3801 3322 3136 3181 M15561 GO_PEPTIDYL_LYSINE_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_TRIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. 14/28 Gene Ontology BP GO:0018023 0.0324160459177351 0.0408655175661266 2570 3005.54545454545 3008 0.00299125213627919 1584 0.90350486504068 -1.00861198548302 -1 1.48627342924381 2567 3884 3008 4287 4174 1776 1584 1620 4189 3785 2187 3182 M15806 GO_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLIC_PROCESS.html The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. 21/78 Gene Ontology BP GO:0019748 0.000120348619081323 0.000214584730566276 4420 2867.81818181818 3009 1.0941382102412e-05 884 2.08136709985019 -1.58400304370477 -1 9.04489503628701 4418 3009 1364 1609 2474 3958 4606 3336 884 1689 4199 3183 M12939 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. 6/16 Gene Ontology BP GO:0033008 3.07124863849673e-06 9.65457510395417e-06 3350 2760.81818181818 3010 3.07125288316067e-07 803 1.53432697482883 1.53432697482883 1 9.11569920898129 3349 1129 3984 1881 1414 4385 4538 3010 803 3130 2746 3184 M13683 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. 13/18 Gene Ontology BP GO:1902165 0.000250750167857585 0.000419241278128471 4340 3107.90909090909 3010 2.27980683871139e-05 2199 1.78012815761649 -1.90016000177756 -1 7.12244740576529 4339 3805 2548 2790 2638 2981 3010 3361 2199 3174 3342 3185 M16863 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. 5/15 Gene Ontology BP GO:0043568 7.21828387438728e-07 3.54825657681513e-06 2165 2541.36363636364 3010 7.21828621905133e-08 56 5.05471798239466 5.05471798239466 1 32.6340004342276 2165 4047 4626 2469 3199 3056 3468 56 151 3010 1708 3186 M13853 GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. 9/23 Gene Ontology BP GO:0048642 0.00288969861125229 0.00408055676765341 4435 3095.72727272727 3012 0.000289346316387639 1204 1.41360670923981 -1.39703925928365 -1 4.0010471499586 4434 2565 4145 2619 3138 4255 1706 2943 3012 1204 4032 3187 M15077 GO_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_RECOGNITION.html The process in which a cell in an organism interprets its surroundings. 64/345 Gene Ontology BP GO:0008037 5.24303567359414e-07 2.9687091015241e-06 2545 2661.09090909091 3013 4.76639720283072e-08 680 1.55301694328523 -1.25496115866102 -1 10.1689862513086 2541 3001 1028 3120 680 3404 3303 3973 3255 1954 3013 3188 M14615 GO_MUSCLE_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_FATE_COMMITMENT.html The process in which the cellular identity of muscle cells is acquired and determined. 4/19 Gene Ontology BP GO:0042693 0.00132624217124183 0.00195670238356397 3605 3073.18181818182 3014 0.000132703434994951 1299 2.90883983979762 2.90883983979762 1 9.33303083431337 3602 2080 4258 2103 2987 3986 3788 3014 1299 2793 3895 3189 M10092 GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. 8/22 Gene Ontology BP GO:0050855 2.34313095456266e-05 5.10518865416914e-05 1520 2439.63636363636 3015 2.34315566111132e-06 194 1.55784773573809 1.55784773573809 1 7.92066301515682 1516 3748 3530 4075 4047 1359 1034 958 3015 3360 194 3190 M10912 GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. 18/42 Gene Ontology BP GO:0033006 0.00137790183438799 0.00202583857411762 4570 3297.27272727273 3015 0.000125342327090153 2220 1.35781087325741 1.44431373525976 1 4.3322877150194 4567 2220 2628 2643 2979 3159 3992 4186 2896 3015 3985 3191 M11546 GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of B cell proliferation. 18/57 Gene Ontology BP GO:0030890 0.00781779573622875 0.01051507114812 4590 3248.45454545455 3016 0.00071324687390935 2263 1.47437150925843 -0.825581267342427 -1 3.45503408325016 4590 2698 2263 2522 3271 3348 4303 2853 2292 3016 4577 3192 M13357 GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS.html A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 11/28 Gene Ontology BP GO:0097067 0.00145300690321982 0.00213153587729846 3050 2891.54545454545 3016 0.000132178858278433 1068 2.25729153897465 -2.38710348362181 -1 7.14314576778859 3049 3016 1068 3850 2985 2633 2964 3306 3660 2236 3040 3193 M13390 GO_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINESIS.html Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. 35/100 Gene Ontology BP GO:0032465 0.01997651638153 0.0256572518836635 4235 2858.18181818182 3018 0.00183274979817897 1395 1.25336046649618 -1.25336046649618 -1 2.36192769824834 1832 4233 3018 4233 3847 1395 2327 1717 3584 3854 1400 3194 M14264 GO_PROTEIN_DEGLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEGLYCOSYLATION.html The removal of sugar residues from a glycosylated protein. 11/22 Gene Ontology BP GO:0006517 0.000991054418701497 0.00148848559920792 3745 3190.90909090909 3018 9.01364681772299e-05 2033 0.902216231868497 -0.686749860293423 -1 3.02171522461364 3742 2033 2633 2433 2923 3058 4098 4371 3856 2935 3018 3195 M16839 GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-12 production. 41/124 Gene Ontology BP GO:0032655 0.0839184282471183 0.0949861682962873 3365 3002.09090909091 3018 0.00793650793650794 1782 1.56233004720296 -1.63121345780166 -1 1.89210702269291 3362 3571 1912 2604 4514 2447 3543 3018 3273 1782 2997 3196 M16299 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE.html The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. 14/57 Gene Ontology BP GO:0001990 6.17019629128784e-05 0.000117893915145883 3745 3052 3019 5.60942668140715e-06 1426 1.78618566446797 -1.22347896612239 -1 8.31251271379746 3745 1426 1662 3341 2306 4290 2805 3733 3019 2630 4615 3197 M12708 GO_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of mast cell degranulation. 18/42 Gene Ontology BP GO:0043304 0.00137790183438799 0.00202583857411762 4570 3299.36363636364 3020 0.000125342327090153 2221 1.35781087325741 1.44431373525976 1 4.3322877150194 4568 2221 2629 2644 2980 3160 3993 4195 2897 3020 3986 3198 M16089 GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. 68/204 Gene Ontology BP GO:0002698 0.000152314509042707 0.000264966753647541 3725 2803.09090909091 3020 1.38477323079569e-05 1282 1.74580271750134 -1.72561281787208 -1 7.39722571978477 3721 3459 1840 3105 2536 2650 4143 3020 1979 1282 3099 3199 M15933 GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING.html The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. 10/23 Gene Ontology BP GO:0000729 0.0286375872153278 0.0362992949606243 2185 2922.63636363636 3021 0.0026379366666825 785 0.650191861704661 -0.650191861704661 -1 1.10920589423478 2184 3642 3021 3431 4046 1550 785 2044 4389 4584 2473 3200 M13431 GO_METHIONINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 8/16 Gene Ontology BP GO:0009086 0.00151390976258474 0.00221527987005388 2385 3147.45454545455 3023 0.000151494211780038 2382 1.39967310273171 1.39967310273171 1 4.40148233829288 2382 2822 4075 3631 3023 3253 2690 2897 3667 2528 3654 3201 M15721 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. 32/65 Gene Ontology BP GO:2001238 0.00167476364875526 0.00243759486557074 4385 3352 3024 0.000152367266671981 1685 1.14181013178337 -1.13973448643111 -1 3.53441540620279 4381 1685 2797 2954 3024 3844 4113 4489 3000 2713 3872 3202 M15918 GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. 4/13 Gene Ontology BP GO:0002320 0.00974210317409737 0.0129420844169769 2340 3261.45454545455 3024 0.000978507742157145 1316 0.835691447716314 -0.835691447716314 -1 1.86906620916891 2339 3024 4479 3321 4452 2988 2479 1316 4052 4582 2844 3203 M13269 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 12/18 Gene Ontology BP GO:0010801 0.0176198644826335 0.0227816849882671 1285 2851.27272727273 3026 0.00161478048719058 1281 0.733930038902884 0.733930038902884 1 1.42795635444882 1281 3014 3026 3654 3372 1668 2037 3260 3628 4397 2027 3204 M11065 GO_PRIMITIVE_STREAK_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMITIVE_STREAK_FORMATION.html The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. 8/19 Gene Ontology BP GO:0090009 2.00280943019551e-05 4.44504980133736e-05 4110 2831.09090909091 3027 2.00282748102974e-06 1214 1.1033947753797 0.887283290048074 1 5.68866152753926 4109 1214 3681 1301 1992 3027 3235 2619 3512 2515 3937 3205 M11907 GO_HISTONE_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEUBIQUITINATION.html The modification of histones by removal of ubiquitin groups. 10/27 Gene Ontology BP GO:0016578 0.00014116532889908 0.000247893578698347 4295 2690.36363636364 3027 1.2834035248694e-05 405 0.801403178888351 -0.801403178888351 -1 3.4231247079271 1946 3746 3027 3924 4637 1053 1722 547 4294 4293 405 3206 M13689 GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex assembly. 218/505 Gene Ontology BP GO:0043254 4.43420278793439e-07 2.74343418554066e-06 3995 2939.27272727273 3029 4.03109425606266e-08 599 1.40551181369108 1.56238418383596 1 9.26020301854637 3991 1961 2739 1596 599 3029 4107 4451 2006 3845 4008 3207 M11003 GO_POLYOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 47/118 Gene Ontology BP GO:0019751 1.57412098187602e-06 6.04654396216291e-06 3310 2809.45454545455 3030 1.43102009834157e-07 1110 1.09172170458581 -0.991468520092729 -1 6.74893158173744 3308 3030 2572 4144 1110 2003 3243 2988 3319 3235 1952 3208 M10079 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. 24/56 Gene Ontology BP GO:1903573 1.25799059222577e-05 3.00609898080507e-05 3105 2833 3032 1.14363435058954e-06 1364 0.873343680133906 -0.716030896441606 -1 4.67835712402203 3103 3150 3032 3009 1817 1364 2085 3298 4020 3975 2310 3209 M10435 GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 10/25 Gene Ontology BP GO:0043555 2.2835420548206e-05 4.99410539827228e-05 3335 2942.81818181818 3032 2.07596887066374e-06 1651 0.670261843088985 -0.666661881285216 -1 3.41543938247029 3335 1651 3215 3032 2001 2448 3942 2808 3056 4202 2681 3210 M10637 GO_SEROTONIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. 4/21 Gene Ontology BP GO:0042428 8.44917333073168e-07 3.92295117745872e-06 3035 2927.54545454545 3033 8.44917654321725e-08 917 3.06908479856712 3.06908479856712 1 19.6559523449082 3033 3618 3613 2939 917 4174 3997 2336 1213 2770 3593 3211 M12992 GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrate derivative. 296/665 Gene Ontology BP GO:1901137 5.05293108287058e-07 2.91076414612508e-06 2955 2947.63636363636 3033 4.59357476674684e-08 661 1.29357647627692 1.48004028064773 1 8.48331622028912 2951 1882 2637 3622 661 4326 3383 3242 2810 3033 3877 3212 M11292 GO_HORMONE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_TRANSPORT.html The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 37/118 Gene Ontology BP GO:0009914 0.00535757164046021 0.00735952814398129 3125 2933.36363636364 3037 0.000488242125071532 1270 1.78039848562107 1.80978504163764 1 4.49900584120968 3125 2782 1270 3037 3218 3379 1967 4211 2861 2268 4149 3213 M14089 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 17/43 Gene Ontology BP GO:0051024 0.0839184282471183 0.0949861682962873 3095 2879 3041 0.00793650793650794 1910 1.99456826836261 -1.87196295723234 -1 2.41558264943805 3095 3041 1910 2021 3603 2691 3584 3993 2155 2329 3247 3214 M15340 GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. 131/336 Gene Ontology BP GO:0002218 3.02650552012135e-06 9.54581402769266e-06 3045 2810.45454545455 3041 2.7513724396778e-07 1380 1.26909208874563 -1.31028164425667 -1 7.54729002277753 3041 3873 2887 4022 1380 1432 2404 3101 3287 3524 1964 3215 M10240 GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that activates or increases the frequency, rate or extent of protein binding. 58/132 Gene Ontology BP GO:0032092 1.82636902915235e-05 4.13448630051408e-05 2570 2938.90909090909 3042 1.66034926477734e-06 1936 1.46893332011737 1.77275551635356 1 7.62796814219778 2570 2458 2383 3083 1936 3747 3042 4184 2681 3188 3056 3216 M10072 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY.html Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 66/138 Gene Ontology BP GO:0090175 0.00102187155839903 0.00152902018873565 1650 2990.54545454545 3043 9.2940592128228e-05 1647 1.2612304228847 1.28649798882623 1 4.20669750152814 1647 3306 3228 3087 2931 3724 2886 2865 3043 3231 2948 3217 M11832 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS.html The somatic process that results in the generation of sequence diversity of immunoglobulins. 13/29 Gene Ontology BP GO:0016445 7.54721210380228e-05 0.000141069669073889 1920 2817.45454545455 3043 6.86133729744987e-06 426 0.616449660883878 -0.654804229091331 -1 2.81190129284404 1917 3043 3123 4070 4541 1688 2029 426 3948 4290 1917 3218 M12080 GO_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. 49/163 Gene Ontology BP GO:0042752 1.68283739934143e-06 6.31131990722317e-06 4320 2926.81818181818 3045 1.52985335144459e-07 911 1.72501622762461 2.08219175319561 1 10.6258706034689 4318 3460 911 2996 1145 3045 4386 3844 2332 1288 4470 3219 M12669 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. 10/21 Gene Ontology BP GO:0046500 0.000542119694545587 0.000856434753921457 3205 2840.90909090909 3047 4.92957571567154e-05 1424 2.01438358361348 -2.01438358361348 -1 7.31942962502051 3205 3187 2368 3507 2784 3276 3047 1957 1424 3578 2917 3220 M13110 GO_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_PRODUCTION.html The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. 8/36 Gene Ontology BP GO:0032609 0.170054455709802 0.188260094864237 2275 3208.54545454545 3047 0.0184668774453728 2192 1.00356937809906 -1.00356937809906 -1 0.862198849642638 2271 4258 4015 3047 4069 2277 2880 2667 4231 3387 2192 3221 M15405 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. 10/38 Gene Ontology BP GO:1901984 0.0460835905558572 0.0569968329650626 2905 3011.81818181818 3047 0.00427983642109632 1507 0.521781820512482 -0.521781820512482 -1 0.769021685467613 2905 3047 3137 3013 3577 1507 1750 3503 4470 4549 1672 3222 M14291 GO_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_CHEMOTAXIS.html The movement of a macrophage in response to an external stimulus. 8/17 Gene Ontology BP GO:0048246 0.0109104159828251 0.0143789558354405 2470 3070.27272727273 3049 0.00109643558077824 2469 2.44301185075144 -2.44301185075144 -1 5.331598573803 2469 3049 4220 3449 3325 2491 3659 2907 3103 2533 2568 3223 M12780 GO_REGULATION_OF_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ORGANIZATION.html Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. 15/33 Gene Ontology BP GO:0090224 0.0183096030731097 0.0236274283125204 1765 2713.72727272727 3050 0.00167852591670605 799 0.561131961762008 -0.561131961762008 -1 1.08123179327776 1762 3606 3050 3240 4532 951 799 1812 4368 4356 1375 3224 M14193 GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of cytoplasmic transport. 325/775 Gene Ontology BP GO:1903649 4.59850994544952e-07 2.78730492769333e-06 2925 3085.18181818182 3051 4.18046446058633e-08 616 1.40367957244572 1.6395602651412 1 9.23667456344413 2921 3931 2688 3791 616 4614 3051 2607 2785 3856 3077 3225 M14757 GO_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLATION.html The covalent attachment of a fucosyl group to an acceptor molecule. 9/29 Gene Ontology BP GO:0036065 0.0765897756730953 0.0916038970762961 3275 3164.27272727273 3051 0.00793650793650794 2602 1.32752377323963 -1.64811701206332 -1 1.63250047503806 3274 2644 4288 3919 3795 2676 3248 2614 2602 2696 3051 3226 M15885 GO_NAD_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. 8/16 Gene Ontology BP GO:0009435 0.0384588910790599 0.0479883448750538 3055 3076.27272727273 3051 0.0039141157893816 1946 1.23954229107491 -1.50791382351431 -1 1.93659658818758 3051 1946 4473 2467 3497 2925 3862 3724 2185 2543 3166 3227 M10572 GO_PROTEIN_HOMOTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTETRAMERIZATION.html The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. 42/87 Gene Ontology BP GO:0051289 2.03635943117234e-06 7.23658446744621e-06 3055 2767.90909090909 3055 1.85123756005961e-07 1182 1.68653631526795 -1.34538625032847 -1 10.2701372932095 3941 1475 2073 3055 1217 3055 3663 3840 1182 3316 3630 3228 M15746 GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 199/495 Gene Ontology BP GO:0072521 1.38303993523654e-05 3.24315879762791e-05 2885 3078.90909090909 3055 1.25731693623279e-06 1859 1.29670731263569 -1.03324549535265 -1 6.89560913506738 2884 3727 3055 3825 1859 2304 2552 3837 2767 3949 3109 3229 M14777 GO_POSITIVE_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SIZE.html Any process that increases cell size. 12/21 Gene Ontology BP GO:0045793 0.161385165508919 0.178875942577683 2285 3178.09090909091 3056 0.0158730158730159 2069 1.3295625770569 1.48321865378973 1 1.17724616846405 2281 4198 2069 3501 4586 2725 2652 3801 3732 3056 2358 3230 M10613 GO_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 100/221 Gene Ontology BP GO:0051783 4.6632686225473e-07 2.80251696730727e-06 3500 2816.54545454545 3058 4.23933601000501e-08 626 1.56756492025177 -1.38449938664627 -1 10.3107049690879 3499 3517 2200 3234 626 2602 2718 3058 2811 3541 3176 3231 M14047 GO_ACTIVATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_IMMUNE_RESPONSE.html Any process that initiates an immune response. 213/757 Gene Ontology BP GO:0002253 1.53233452965688e-06 5.94868663979674e-06 4175 2850.63636363636 3062 1.39303236086634e-07 1100 1.50037506489058 -1.28036378614819 -1 9.28778751333602 4173 3331 2083 3137 1100 2212 3646 3402 2524 3062 2687 3232 M10513 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 67/192 Gene Ontology BP GO:1903555 0.000772950007015474 0.00118403394344205 3390 2854.54545454545 3063 7.02928826936203e-05 1092 1.68201392827182 -1.52997389855864 -1 5.83144591417029 3388 3141 1092 2443 2873 2677 3402 4431 3063 1479 3411 3233 M15204 GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 8/22 Gene Ontology BP GO:0006700 3.60034037160297e-05 7.33496285447678e-05 4280 2819.81818181818 3063 3.60039870396163e-06 244 1.61801396085801 -0.762989672280238 -1 7.92490368896043 4276 1296 4369 1745 2181 3387 4605 2448 244 3404 3063 3234 M11081 GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY.html The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. 15/35 Gene Ontology BP GO:0007250 0.000251675758158384 0.000420485982414314 4490 3148.81818181818 3064 2.28822321810752e-05 1471 1.649075481702 -1.37170102634076 -1 6.59557900614864 4487 4095 2042 2476 2641 3064 3749 3825 2302 1471 4485 3235 M15497 GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. 25/80 Gene Ontology BP GO:0042149 5.9243099666613e-05 0.000113767070498123 3075 2752.63636363636 3064 5.38588136957563e-06 591 1.87278787702411 2.57858861476488 1 8.74987177483951 3075 4159 1623 3142 2293 3883 3324 591 2134 3064 2991 3236 M11810 GO_REGULATION_OF_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_FORMATION.html Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. 11/52 Gene Ontology BP GO:0003156 0.00211892421666695 0.00303928487426155 4315 2961.27272727273 3066 0.000192815255370942 449 2.60647102768464 -1.41388350586424 -1 7.77237176621554 4314 3015 1575 1672 3066 4006 4359 4171 449 2230 3717 3237 M16823 GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION.html A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. 13/30 Gene Ontology BP GO:0034629 0.0839184282471183 0.0949861682962873 4245 3044.81818181818 3066 0.00793650793650794 1484 1.90665744936158 -1.40521503926117 -1 2.30911550048769 4245 3885 1484 3017 3673 3130 2347 3066 1543 2494 4609 3238 M12417 GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 16/29 Gene Ontology BP GO:0045978 0.055081976456247 0.0675860509213412 3835 3181.54545454545 3068 0.00513740388006014 1673 0.808078511279579 0.808078511279579 1 1.12013384614992 3834 3068 2979 3494 3537 2104 1673 2984 4024 4337 2963 3239 M14410 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 16/50 Gene Ontology BP GO:0045078 0.000234954602279307 0.000396400515400735 4165 3085.72727272727 3068 2.13617907824331e-05 1479 1.14507013097841 -1.55714861113359 -1 4.61452714956572 4162 3219 2639 2731 2623 3649 4456 1479 2487 3430 3068 3240 M13830 GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. 16/29 Gene Ontology BP GO:1903579 0.055081976456247 0.0675860509213412 3835 3194.63636363636 3069 0.00513740388006014 1674 0.808078511279579 0.808078511279579 1 1.12013384614992 3835 3069 2980 3495 3538 2105 1674 3015 4025 4441 2964 3241 M14629 GO_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of B cell proliferation. 31/96 Gene Ontology BP GO:0030888 0.00214285671664695 0.00306981910996353 3110 2916.54545454545 3070 0.000194995160450326 1429 1.41748145998877 -0.994073285277369 -1 4.2195711323644 3106 3279 2438 3416 3070 1429 2230 4544 3191 3035 2344 3242 M14826 GO_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_SIGNALING.html A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. 11/20 Gene Ontology BP GO:0031929 0.151900881268155 0.169130885306485 1835 3049.63636363636 3070 0.014866366625095 1831 0.775679437346387 -0.775679437346387 -1 0.709171422049671 1831 3529 3070 4020 3717 1877 2267 2127 4268 4503 2337 3243 M15358 GO_RESPONSE_TO_X_RAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_X_RAY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). 20/37 Gene Ontology BP GO:0010165 0.00113752241270507 0.00169170934086792 3510 2745.36363636364 3072 0.000103464636472446 844 1.86811165725977 2.71803764471647 1 6.13370663540439 2918 2758 2077 3189 3506 3702 3508 844 950 3675 3072 3244 M15465 GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 12/29 Gene Ontology BP GO:0032075 0.0110561933238652 0.0145628101000584 2615 3230.45454545455 3072 0.00101019552670448 1326 0.707849354486911 0.813430500244111 1 1.54017352761072 2614 4303 2964 3095 4618 3072 2674 1326 4388 4556 1925 3245 M11711 GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 5/17 Gene Ontology BP GO:0009214 0.0505995890051796 0.0623828708845058 3010 3219.18181818182 3074 0.00517900645803996 2170 1.2575840401638 1.2575840401638 1 1.79505683098323 3006 2879 3794 3513 3539 3543 3074 2170 4010 2979 2904 3246 M15849 GO_DORSAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. 9/28 Gene Ontology BP GO:0021516 0.00288826991417546 0.00407978010694148 3655 3039 3075 0.000289203074184075 1317 1.78186024203061 -2.11758396296931 -1 5.04352029923943 3654 2409 4466 2572 3137 3075 1317 4175 2411 1928 4285 3247 M10958 GO_TRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. 103/180 Gene Ontology BP GO:0006399 0.00221678650081457 0.0031718150148789 2065 2866 3076 0.000201729396184782 595 0.789618514672643 -0.801723912633211 -1 2.33726450897418 595 4179 3481 4595 3076 1590 2061 2063 3568 4161 2157 3248 M10078 GO_MITOTIC_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CYTOKINESIS.html A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. 19/56 Gene Ontology BP GO:0000281 0.0839184282471183 0.0949861682962873 3990 2968.09090909091 3078 0.00793650793650794 850 3.24842941945222 -1.48156696483023 -1 3.93411044218405 3988 2981 1208 2753 3609 4040 4298 2091 850 3078 3753 3249 M12262 GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 18/62 Gene Ontology BP GO:0045072 0.00489119435449185 0.00674281929569646 3685 3074.72727272727 3078 0.000445645706307608 1239 1.14507013097841 -1.55714861113359 -1 2.94510962447139 3683 3371 2558 2838 3197 3078 4436 1239 3001 3547 2874 3250 M15044 GO_RESPONSE_TO_THYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_THYROID_HORMONE.html A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 16/42 Gene Ontology BP GO:0097066 1.10359933384847e-05 2.684133948171e-05 3085 2731.90909090909 3079 1.00327715449052e-06 1271 1.53007087236514 -1.63199670062441 -1 8.28551268620847 3084 2510 1271 3555 1785 2607 3134 3097 3665 2264 3079 3251 M15257 GO_REGULATION_OF_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ASSEMBLY.html Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 12/28 Gene Ontology BP GO:0090169 0.00700575176206245 0.00947224968877576 1390 2644.27272727273 3082 0.000638923734153498 680 0.561131961762008 -0.561131961762008 -1 1.34510389955153 1387 3889 3082 3282 4112 680 729 1556 4493 4539 1338 3252 M16527 GO_RESPONSE_TO_REDOX_STATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REDOX_STATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. 19/54 Gene Ontology BP GO:0051775 6.10198479012889e-06 1.64813934732801e-05 3700 3152.81818181818 3084 5.54727428621757e-07 1611 1.41466813428128 1.12456855919263 1 8.01555343838016 3700 2951 2443 2023 1611 4058 3537 4564 2179 3084 4531 3253 M11700 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. 10/33 Gene Ontology BP GO:0002675 0.00774879129652326 0.0104313244388975 2975 3094.54545454545 3085 0.000706929023817511 1770 1.81713597551502 1.30886889997914 1 4.26574234473782 2974 3322 1770 3085 3270 3816 2343 4081 2576 2813 3990 3254 M12791 GO_POLYOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSPORT.html The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/22 Gene Ontology BP GO:0015791 0.00216278038416698 0.00309645060859923 4030 3064.81818181818 3085 0.000216488820049 1913 3.16445150237229 2.97328159107691 1 9.40590618074519 3584 2238 3961 2120 3085 4029 2282 4027 2742 1913 3732 3255 M15030 GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. 17/44 Gene Ontology BP GO:0031062 0.000847828877540071 0.00128895529745205 2655 2738.72727272727 3085 7.71050715889599e-05 707 0.955005304208349 -0.955005304208349 -1 3.26923213745724 2651 3255 3085 3239 3063 1263 1816 3102 4076 3869 707 3256 M16543 GO_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_PATTERNING.html The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. 19/52 Gene Ontology BP GO:0021532 0.000735252937025532 0.00113226513652058 4030 3273.63636363636 3085 6.68635252649515e-05 2447 1.33174953099296 1.19899473212329 1 4.64772994211938 4026 2663 2447 3034 2859 4321 2509 3163 3435 3085 4468 3257 M12973 GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. 6/13 Gene Ontology BP GO:0060576 0.0381941342530805 0.047680246663365 3305 2944.72727272727 3087 0.00388669232679231 1770 1.91532858618835 -1.69834478895059 -1 2.99875779561448 3305 3537 3987 2675 3496 2900 1770 2073 3087 2184 3378 3258 M13992 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 13/23 Gene Ontology BP GO:0009147 0.514011397665828 0.542522145797326 2425 3335.63636363636 3087 0.0634920634920635 2423 0.686185989175764 -0.711939850730658 -1 0.215881818207762 2423 3439 3087 3889 4034 2608 2653 2991 4037 4449 3082 3259 M14657 GO_CELLULAR_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 101/213 Gene Ontology BP GO:0071478 0.00021504490759001 0.000364931836966527 2250 3131.45454545455 3088 1.95514482371767e-05 1976 1.46632349728642 1.93383342470385 1 5.97154756405233 2250 4224 2562 4256 2605 3937 2473 1976 3254 3821 3088 3260 M13100 GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. 57/171 Gene Ontology BP GO:0050709 0.0343207389092253 0.0431144996632936 4340 3134.09090909091 3089 0.00316983160180527 1542 1.48852694032043 1.43346389222983 1 2.40761460305851 3089 2055 1542 2620 3458 4337 3662 4336 3078 2152 4146 3261 M14681 GO_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMETE_GENERATION.html The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. 272/1037 Gene Ontology BP GO:0007276 1.59178204943156e-05 3.66417652727354e-05 2935 3244.27272727273 3089 1.44708506062274e-06 1893 1.40775520591109 1.63787371645932 1 7.39773881616234 2931 4219 2863 4096 1893 3837 2743 3089 2833 3801 3382 3262 M16819 GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 27/55 Gene Ontology BP GO:0010823 6.16878018150411e-06 1.66132555793595e-05 4130 2905.36363636364 3090 5.60799770797824e-07 1618 1.12254240792139 -0.805759374821814 -1 6.3557575445342 4128 3090 2948 2306 1618 1737 1874 3963 3347 3629 3319 3263 M14887 GO_INTERACTION_WITH_SYMBIONT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_SYMBIONT.html An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 24/80 Gene Ontology BP GO:0051702 0.0839184282471183 0.0949861682962873 2915 3279.90909090909 3091 0.00793650793650794 2292 1.53480234434922 -1.5365780740754 -1 1.85876873653776 2913 4239 2292 4157 4314 3091 2389 2697 3278 2963 3746 3264 M11974 GO_PSEUDOURIDINE_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHESIS.html The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. 10/17 Gene Ontology BP GO:0001522 0.00247320990546156 0.00351918896446768 1060 2505.27272727273 3092 0.000225090421633963 1052 0.779005003883213 -0.779005003883213 -1 2.26419721201554 1056 3189 3155 3801 3092 1052 1114 1734 3394 4305 1666 3265 M10565 GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS.html The process in which the left cardiac ventricle is generated and organized. 4/18 Gene Ontology BP GO:0003214 0.0201262600473346 0.0258424295906457 2960 3129.18181818182 3097 0.00203108977999088 2182 1.29214926568553 -1.29214926568553 -1 2.43024361485056 2956 2803 3605 3227 3403 2883 3491 2182 4005 2769 3097 3266 M16568 GO_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_AGING.html Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 28/53 Gene Ontology BP GO:0090342 0.00252620449412248 0.0035912943864699 4130 3020.18181818182 3097 0.000229919085712365 1190 1.53551559492433 -0.767973524826272 -1 4.44699299106682 4129 4125 2369 3337 3097 2858 2917 1190 2010 3684 3506 3267 M16777 GO_RESPONSE_TO_WATER_DEPRIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER_DEPRIVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. 4/17 Gene Ontology BP GO:0009414 0.0266156943173693 0.033838080152121 3490 3009.81818181818 3099 0.00269399515524332 1355 2.0338271805914 -0.844053965741403 -1 3.54311147512923 3490 2529 4618 2671 3453 3980 3099 1595 1355 2802 3516 3268 M13920 GO_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that modulates the frequency, rate or extent of protein acetylation. 42/101 Gene Ontology BP GO:1901983 0.000101422405709282 0.000183803368348241 2630 3099.54545454545 3101 9.22064379044442e-06 1947 1.37628116144743 1.24389096960944 1 6.0904716180837 2626 3592 1947 3824 2438 3101 2426 4457 3404 3634 2646 3269 M13745 GO_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_POLARITY.html The maintenance of established anisotropic intracellular organization or cell growth patterns. 3/17 Gene Ontology BP GO:0030011 0.00247995578745048 0.00352770671603326 3995 2786.90909090909 3102 0.000248272772346986 352 1.15385815501466 1.15385815501466 1 3.35228286169673 1811 3993 4126 3102 3995 1226 352 4593 3959 2590 909 3270 M15776 GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION.html The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. 11/35 Gene Ontology BP GO:0021799 0.0318765750701316 0.0402400592851063 3245 3194.90909090909 3102 0.00294073071390289 2407 1.08617129317061 0.934266252895327 1 1.79538044928768 3243 2846 2407 3076 3444 4532 3205 2778 3102 2946 3565 3271 M10908 GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE.html The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. 8/15 Gene Ontology BP GO:0016254 0.00115838248455855 0.00172052779136448 2290 3066.72727272727 3103 0.000115898676041919 2026 0.615796688638369 -0.615796688638369 -1 2.01653739891023 2287 2710 3657 3643 2962 2026 3103 3258 3604 4230 2254 3272 M10915 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. 192/441 Gene Ontology BP GO:0090316 8.32887927493177e-06 2.12594757963212e-05 2580 3116.54545454545 3103 7.57173709729238e-07 1702 1.47050858129483 1.69619270307952 1 8.13935518539859 2579 4115 2649 4251 1702 4022 3159 2621 2133 3948 3103 3273 M12454 GO_SPHINGOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. 7/13 Gene Ontology BP GO:0046519 0.00586178602046271 0.00798833944614275 2930 3264.09090909091 3103 0.000587730590946203 2362 0.622808851656478 -0.657673300437825 -1 1.54754533349035 2928 2369 3910 3103 3243 2362 2385 4092 4213 4341 2959 3274 M14154 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. 26/69 Gene Ontology BP GO:0060761 0.00270342357480134 0.00383501242218229 2660 2969.36363636364 3103 0.000246068304198902 2245 1.36492198767253 -1.48236559404427 -1 3.90683074292921 2659 2755 2674 3262 3106 2245 3314 3832 3393 3103 2320 3275 M14717 GO_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEPHOSPHORYLATION.html The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. 137/325 Gene Ontology BP GO:0016311 2.29709756423593e-07 1.93916799831772e-06 3635 3094.45454545455 3105 2.08827073098548e-08 348 1.3198513170007 -1.01886025345767 -1 8.93141906285047 3631 3105 2839 3994 348 3920 3055 3354 2397 3097 4299 3276 M13599 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate, or extent of mast cell activation. 8/21 Gene Ontology BP GO:0033005 3.14707432453058e-06 9.83619411107194e-06 4550 2948.72727272727 3106 3.14707878137403e-07 993 1.39984022725464 1.53432697482883 1 8.30326831768497 4546 1585 4101 2086 1423 3106 3597 3828 993 2529 4642 3277 M16567 GO_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. 22/56 Gene Ontology BP GO:0051972 0.00105531996723799 0.00157652850961583 4265 3036.18181818182 3106 9.59842304403286e-05 1234 2.11229527294467 -1.41602267610925 -1 7.0120817074257 4263 3093 2080 3424 2937 2839 3190 3106 1234 3324 3908 3278 M13303 GO_TRANSEPITHELIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSEPITHELIAL_TRANSPORT.html The directed movement of a substance from one side of an epithelium to the other. 6/18 Gene Ontology BP GO:0070633 0.00060763970416357 0.000952488570706096 3315 3144.81818181818 3107 6.07805919837855e-05 2374 1.20732328386539 -1.78129570371399 -1 4.32088186405931 3315 2935 4048 3107 2826 2374 2896 3303 4017 3135 2637 3279 M14492 GO_TRACHEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_MORPHOGENESIS.html The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. 8/21 Gene Ontology BP GO:0060439 0.0490591574141715 0.0605319340616525 3685 3205.54545454545 3107 0.00501771140145113 1929 1.88688689230636 -2.73142089975336 -1 2.72255397222082 3685 3893 4245 2691 3533 3107 3867 1929 2766 2534 3011 3280 M15265 GO_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. 92/251 Gene Ontology BP GO:0034341 3.11522033144286e-05 6.46867978483416e-05 3180 2996.18181818182 3107 2.83205858556831e-06 1272 1.63545073404161 1.65689703788139 1 8.11605440935584 3178 3107 1458 2942 2106 4452 4043 3127 3099 1272 4174 3281 M15604 GO_HEME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. 15/21 Gene Ontology BP GO:0006783 0.00149721334922383 0.00219292163421017 2345 2912.18181818182 3108 0.000136203022901381 1261 1.73936216062459 -0.975254497334946 -1 5.47876343511075 2342 3799 3108 3758 2993 1261 1884 3547 3659 3812 1871 3282 M10423 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN.html The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. 6/27 Gene Ontology BP GO:0001991 0.000365278458712668 0.000591348634519846 2795 3038.72727272727 3109 3.65338515365401e-05 1261 1.28169941881469 -0.526507809098099 -1 4.90138376396445 2794 2741 3582 3857 2732 3366 2832 1261 3874 3109 3278 3283 M10780 GO_PROTEIN_N_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. 40/81 Gene Ontology BP GO:0006487 0.0165187800291299 0.0214236580098463 2700 3121.09090909091 3110 0.00151310287048972 2263 1.09668498628674 1.29919178177965 1 2.1684213677662 2699 3110 3152 3681 3365 3893 2814 2263 3418 2875 3062 3284 M14366 GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS.html A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. 15/34 Gene Ontology BP GO:0034067 4.53984140322444e-05 9.01175016467339e-05 1940 3008 3110 4.12721371679664e-06 1775 0.607396299799596 -0.607396299799596 -1 2.91064345941156 1938 3343 3260 3885 2217 1783 3110 2976 4331 4470 1775 3285 M14107 GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 10/45 Gene Ontology BP GO:0050996 0.00284711721620108 0.00402777734150567 3145 2988.81818181818 3111 0.000259164407816858 1422 0.815687718844737 0.920150371615191 1 2.31417052654579 3141 1986 2784 2180 3111 4216 3634 1422 3779 3585 3039 3286 M13837 GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 61/138 Gene Ontology BP GO:0033209 0.0839184282471183 0.0949861682962873 3000 3286.09090909091 3112 0.00793650793650794 1872 1.68342445052347 -1.51869649662336 -1 2.03876219007599 2997 4084 2803 3713 3863 1872 2500 4437 2995 3771 3112 3287 M10795 GO_MALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. 6/30 Gene Ontology BP GO:0030539 0.0719536819370335 0.0873642639209327 2815 3131.54545454545 3113 0.00743955208342629 1877 2.89542784536298 -2.89542784536298 -1 3.63119595318171 2815 2877 3637 2298 3649 2863 4278 1877 3872 3113 3168 3288 M12066 GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE.html Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. 5/16 Gene Ontology BP GO:0010889 5.32183481558014e-05 0.000103602847164522 3450 2726 3114 5.32196226854208e-06 860 1.71107025507933 -1.71107025507933 -1 8.07669474148239 3446 860 3844 1482 2287 3223 4257 3276 3114 1972 2225 3289 M14395 GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. 2/11 Gene Ontology BP GO:0045741 0.508972746588872 0.537570623842614 2750 3344.4 3114 0.0759863227208962 2000 0.393663596848385 -0.393663596848385 -1 0.125707213645545 2749 3058 4233 NA 4001 2558 2000 2878 4322 4475 3170 3290 M11117 GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. 10/18 Gene Ontology BP GO:0045820 0.00260566924993091 0.00369973159860221 3080 3219.45454545455 3116 0.000237160047170129 1720 0.808078511279579 0.808078511279579 1 2.32790106298622 3079 2816 2664 3477 3101 3599 3502 1720 4094 4246 3116 3291 M16696 GO_CENTROSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_LOCALIZATION.html Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. 17/32 Gene Ontology BP GO:0051642 3.33926039130028e-05 6.85722512021548e-05 3540 3060.72727272727 3116 3.03573734290487e-06 2136 1.4440871780209 -0.751976009954791 -1 7.12306082875701 3536 3039 2685 3116 2136 4107 3278 2150 2606 3471 3544 3292 M10818 GO_RNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_STABILIZATION.html Prevention of degradation of RNA molecules. 26/44 Gene Ontology BP GO:0043489 0.0225310286272267 0.0288106763746113 2995 3094.63636363636 3117 0.00206955827477154 2328 1.68909530057791 -1.74430020790751 -1 3.08232657769788 2991 3465 2422 3117 3406 2328 2353 3531 3167 3100 4161 3293 M11590 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 6/23 Gene Ontology BP GO:0010744 0.00982073835585896 0.0130428169869145 2635 3007.45454545455 3117 0.000986441134480194 1318 1.44897842494631 -1.44897842494631 -1 3.23493509987414 2633 3614 3774 3520 3666 2580 2538 1318 3857 3117 2465 3294 M13488 GO_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BROWN_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 17/40 Gene Ontology BP GO:0050873 2.83288813080319e-06 9.07736341705951e-06 3820 3013.36363636364 3117 2.57535616241184e-07 880 1.62282026996436 -1.49756650055292 -1 9.69292295148924 3816 3117 1485 2978 1357 4204 4133 4176 2562 880 4439 3295 M14564 GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 10/18 Gene Ontology BP GO:0051198 0.00260566924993091 0.00369973159860221 3080 3238.36363636364 3117 0.000237160047170129 1679 0.808078511279579 0.808078511279579 1 2.32790106298622 3080 2817 2665 3478 3102 3600 3503 1679 4095 4486 3117 3296 M15248 GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 10/18 Gene Ontology BP GO:0051195 0.00260566924993091 0.00369973159860221 3085 3245.27272727273 3118 0.000237160047170129 1696 0.808078511279579 0.808078511279579 1 2.32790106298622 3081 2818 2666 3479 3103 3601 3504 1696 4096 4536 3118 3297 M10255 GO_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 30/64 Gene Ontology BP GO:0010883 7.61914345231242e-06 1.97408945586421e-05 4400 2916.27272727273 3122 6.92651803583294e-07 1102 1.64988959993887 -1.58341330132298 -1 9.19514693642927 4400 1754 1102 2473 1681 4270 3773 4298 3122 1267 3939 3298 M10418 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 33/100 Gene Ontology BP GO:0042509 2.11396188154335e-05 4.6694219866821e-05 3780 3023.09090909091 3125 1.92180199518385e-06 1251 1.48891986420917 1.42274730096733 1 7.63855355802521 3776 1251 2136 2881 1982 4383 4247 3493 3125 1464 4516 3299 M11502 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 25/54 Gene Ontology BP GO:0090313 6.55295297563826e-05 0.00012438017581664 2980 3173.18181818182 3126 5.95740742819784e-06 2325 0.909475726584313 0.901510192413872 1 4.20743826046543 2980 2660 2984 2828 2325 3796 3126 3538 3391 3533 3744 3300 M15177 GO_INTRACELLULAR_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIPID_TRANSPORT.html The directed movement of lipids within cells. 16/57 Gene Ontology BP GO:0032365 0.64243373672239 0.670748783360031 4595 3467.81818181818 3126 0.0892565663323147 2271 0.837576336109911 0.845991596098289 1 0.172086890642332 4591 2728 2271 2655 4546 3126 2689 2873 4205 3840 4622 3301 M10972 GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. 10/28 Gene Ontology BP GO:0033032 0.00308093409332277 0.00433346773562485 4150 2918.63636363636 3128 0.000280477926126602 1798 1.60970340465749 -0.987400915681651 -1 4.50627554274091 3502 2204 2186 1862 3128 4146 3476 4146 1798 2057 3600 3302 M15162 GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organonitrogen compound. 560/1252 Gene Ontology BP GO:1901566 1.66235090061512e-05 3.80962252297928e-05 3130 3087.81818181818 3128 1.66236333609337e-06 1679 1.3336658830881 -1.10162775052889 -1 6.98169129859397 3128 3271 4363 4392 1937 1679 2587 3180 2509 4011 2909 3303 M10879 GO_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SECRETION.html The controlled release of proteins from a cell. 57/190 Gene Ontology BP GO:0009306 2.58294272574015e-07 2.06058472089545e-06 3475 2953.09090909091 3129 2.34813002635858e-08 391 1.27295967005659 1.37950345784143 1 8.57433098122999 3474 2852 2278 3129 391 3765 2269 3120 3467 3418 4321 3304 M11666 GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS.html The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 11/36 Gene Ontology BP GO:0003203 0.0758117440034634 0.0916038970762961 3130 3153.18181818182 3130 0.00714160285407855 2000 1.04146276741192 -1.04146276741192 -1 1.28072130663749 3130 3074 2231 3659 3581 2539 3947 2000 4132 3648 2744 3305 M15741 GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. 85/214 Gene Ontology BP GO:0060759 0.00484849699493205 0.00668991725036241 3660 3051.45454545455 3130 0.000441746863644942 2480 1.35425630498943 -1.38758578499915 -1 3.48862267280797 3660 2539 2721 3130 3196 2480 3611 2693 3190 3457 2889 3306 M12885 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. 33/92 Gene Ontology BP GO:1903727 0.000715105493035123 0.00110270169517173 2290 2934.54545454545 3133 6.50307311311935e-05 1847 1.50705000177459 1.75416007207363 1 5.28003181888586 2290 3572 1847 3048 2850 3449 3133 2188 3335 3194 3374 3307 M13159 GO_CARNITINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARNITINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. 6/16 Gene Ontology BP GO:0009437 0.0508983237226961 0.062701225005168 2535 3011.63636363636 3134 0.00521031354973591 1560 1.97255238276186 -1.97255238276186 -1 2.81042729586295 2532 3616 4025 3292 4555 1560 2363 3027 3283 3134 1741 3308 M11905 GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 45/125 Gene Ontology BP GO:1903557 0.000341202463592191 0.000555276213970748 3615 2958.45454545455 3135 3.10232175333969e-05 1259 1.63190314528014 -1.46523583647249 -1 6.29345099379356 3613 3243 1259 2479 2696 3068 3716 4307 3135 1666 3361 3309 M15182 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. 479/1288 Gene Ontology BP GO:0045944 2.5104795856935e-07 2.02363831881509e-06 2940 2899.18181818182 3136 2.28225442924652e-08 383 1.49275273617274 1.53147621023224 1 10.0686960689979 2937 3136 1429 3693 383 4420 3362 3912 2639 2222 3758 3310 M13466 GO_BASIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASIC_AMINO_ACID_TRANSPORT.html The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/14 Gene Ontology BP GO:0015802 0.000143924623078243 0.000251786746402519 3960 3206.27272727273 3138 1.43933945361709e-05 2043 1.65925772334124 -0.815045622768238 -1 7.07407609116838 3956 2043 4080 2901 2544 3794 3999 2870 2352 3138 3592 3311 M11797 GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 20/46 Gene Ontology BP GO:0043516 6.40043148229435e-06 1.71182047075419e-05 2325 2896.09090909091 3139 5.81859100278412e-07 1631 1.31877113220683 1.57436404748932 1 7.44647678626834 2322 3179 2898 3139 1631 2824 1957 3204 3470 3917 3316 3312 M15323 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. 5/25 Gene Ontology BP GO:0002689 2.84755254317076e-05 5.99173948635013e-05 4165 2923 3139 2.84758903232851e-06 1128 2.06278941678188 -2.1095112941936 -1 10.318038414896 4165 1220 4386 1128 2110 4598 3139 3549 1258 1986 4614 3313 M11467 GO_REGULATION_OF_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXIT_FROM_MITOSIS.html Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. 16/27 Gene Ontology BP GO:0007096 0.00466109533782229 0.00644282990577817 2770 2905.90909090909 3140 0.000424636372489776 1662 1.13186282744162 -1.13186282744162 -1 2.93764174397425 2767 3498 2850 3140 3192 1947 1662 3693 4021 3421 1774 3314 M12031 GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that activates or increases the frequency, rate or extent of translational initiation. 13/25 Gene Ontology BP GO:0045948 0.000579210464427735 0.000910692240547909 3385 3110.81818181818 3140 5.26693648847542e-05 725 1.39786800902751 -1.75627114929111 -1 5.03509263359419 3382 4196 2807 4290 3929 3140 2708 725 2369 3746 2927 3315 M15614 GO_PROTEIN_PALMITOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PALMITOYLATION.html The covalent attachment of a palmitoyl group to a protein. 12/26 Gene Ontology BP GO:0018345 0.0488766361653924 0.0603227596267721 2735 3234.18181818182 3140 0.00454523037220528 1680 0.320498321921163 -0.369857467328851 -1 0.463010439838988 2735 4065 3140 4295 4025 1680 2364 2686 4321 4567 1698 3316 M16514 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 23/77 Gene Ontology BP GO:1903556 0.047128508129058 0.0582581638027732 2425 3108.72727272727 3142 0.00437904121648338 1902 1.76569902150494 -1.65945002273095 -1 2.58247405296621 3307 3794 1902 3564 3516 2423 3929 3142 3092 2425 3102 3317 M13730 GO_ECTODERMAL_PLACODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_DEVELOPMENT.html The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0071696 0.00174023065968107 0.00252575522128765 3235 3268.81818181818 3143 0.000174159494479966 2150 1.85836770731583 -1.85836770731583 -1 5.71851626979468 3232 3051 4123 2555 3044 3143 4414 3221 3885 3139 2150 3318 M14006 GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. 6/15 Gene Ontology BP GO:0033004 0.0191322811379815 0.0246274414537422 1820 3010.90909090909 3144 0.00192990250538858 708 1.26428725612162 1.26428725612162 1 2.40916427094884 1818 4216 4169 4018 4303 1649 708 2129 4307 3144 2659 3319 M10907 GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 29/68 Gene Ontology BP GO:0048146 0.00944591548166653 0.0125810056171479 3410 3058.09090909091 3145 0.000862428901966303 1672 1.86986418809825 -1.73934454411335 -1 4.20926871001533 3407 4186 1672 2777 3292 2534 3145 3660 3007 2457 3502 3320 M14372 GO_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that modulates the frequency, rate or extent of the transcription of the viral genome. 34/86 Gene Ontology BP GO:0046782 0.00182136329296217 0.00263117292135139 1305 2454.36363636364 3146 0.000165715721440128 325 1.05650502250251 1.02846316395718 1 3.22882122550047 1303 3146 3101 3208 3335 1133 325 3968 3402 3234 843 3321 M16053 GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION.html The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. 42/99 Gene Ontology BP GO:0035335 3.30313810435543e-06 1.02005211002562e-05 4475 3065.45454545455 3146 3.00285733071332e-07 1407 1.21393625236052 -1.18500160731232 -1 7.17784887597139 4474 2497 2386 3146 1407 3675 4243 2704 3224 1863 4101 3322 M16382 GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. 18/171 Gene Ontology BP GO:0050853 0.0240300242751753 0.0306346520344972 3840 3308.72727272727 3146 0.0022087802849789 1691 1.64845133815367 -1.34815453866116 -1 2.95609761576632 3837 2788 1691 2874 3414 4283 3146 4050 2960 3025 4328 3323 M13719 GO_MALE_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS_I.html A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. 11/129 Gene Ontology BP GO:0007141 0.440429798653494 0.468802282243964 2720 3363.45454545455 3149 0.0514118631691884 2122 0.732024623125649 -0.517174830436356 -1 0.285305867172174 2719 4255 2770 3671 4518 2232 2122 2611 4515 4436 3149 3324 M16432 GO_TEMPERATURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TEMPERATURE_HOMEOSTASIS.html A homeostatic process in which an organism modulates its internal body temperature. 10/35 Gene Ontology BP GO:0001659 0.0839184282471183 0.0949861682962873 3720 3172.72727272727 3150 0.00793650793650794 2235 1.58560887225601 -2.08939631505373 -1 1.92029957239813 3717 3190 2650 3409 4534 2416 2235 3622 3134 2843 3150 3325 M12978 GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. 6/26 Gene Ontology BP GO:0002827 0.0032088840932031 0.0044970868834114 2930 3101 3151 0.000321352715374967 1914 2.04582284390522 -1.5881758638962 -1 5.68815998448327 2929 1914 3988 3201 3151 3135 3612 2955 3826 2185 3215 3326 M15012 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 55/120 Gene Ontology BP GO:0071158 6.5609020988564e-06 1.74269270280265e-05 2335 3113 3151 5.96447424095048e-07 1645 1.82976334729977 1.71108519306472 1 10.3149828015271 2333 4613 2413 4248 1645 4308 3506 2644 2067 3315 3151 3327 M12734 GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 16/45 Gene Ontology BP GO:0042036 0.000308193411448106 0.000506887002959106 4295 3279.27272727273 3152 2.8021508553606e-05 1756 2.11451685933206 -2.02166731878801 -1 8.25384471935375 4292 3152 1756 3998 2675 4496 2447 3831 2589 2258 4578 3328 M14497 GO_LIPID_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 42/112 Gene Ontology BP GO:0046834 1.88970497847348e-05 4.24475095067846e-05 3445 3100.63636363636 3152 1.7179283731075e-06 1933 1.56324304391838 -1.27718801234435 -1 8.09653783531644 3442 3462 1933 3518 1950 4357 3152 2979 2257 2953 4104 3329 M16351 GO_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_KILLING.html Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. 45/138 Gene Ontology BP GO:0031341 0.00162580153990909 0.00237153520257552 4275 3106.45454545455 3153 0.000147909477536107 1283 1.82242079084273 -1.53066180825476 -1 5.66697176329901 4271 3175 1283 2779 3019 3153 4584 3583 2983 1668 3673 3330 M15070 GO_MOTILE_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM_ASSEMBLY.html The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function. 21/57 Gene Ontology BP GO:0044458 0.000131220167445788 0.000232274204136788 3455 2961.09090909091 3154 1.19298177087209e-05 867 1.46324782173494 1.3748357472938 1 6.29913154396215 3453 3008 2267 2057 2494 3979 3488 4547 867 3258 3154 3331 M15688 GO_ECTODERMAL_PLACODE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_MORPHOGENESIS.html The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0071697 0.00174023065968107 0.00252575522128765 3235 3299.36363636364 3154 0.000174159494479966 2151 1.85836770731583 -1.85836770731583 -1 5.71851626979468 3233 3052 4441 2556 3045 3144 4415 3216 3886 3154 2151 3332 M13310 GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. 10/35 Gene Ontology BP GO:0002579 0.0337543373161473 0.0424489133691419 2820 3091.36363636364 3155 0.003116693713437 1559 2.24147996817763 2.8510559963051 1 3.64341889473878 2819 3155 1559 3796 3454 3758 3138 2810 3824 2067 3625 3333 M13937 GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. 20/66 Gene Ontology BP GO:0002228 1.97398153828557e-05 4.39577759341003e-05 4330 3107.54545454545 3156 1.79454477303673e-06 1189 0.998654211183141 -0.716723060077522 -1 5.15438789035359 4328 1189 3052 2773 1965 3156 4116 2140 3250 3922 4292 3334 M15785 GO_ECTODERMAL_PLACODE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_FORMATION.html The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0060788 0.00174023065968107 0.00252575522128765 3235 3302.27272727273 3156 0.000174159494479966 2152 1.85836770731583 -1.85836770731583 -1 5.71851626979468 3234 3053 4457 2557 3046 3145 4416 3222 3887 3156 2152 3335 M10601 GO_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 68/177 Gene Ontology BP GO:0010921 3.65808845549968e-05 7.43955527765441e-05 3160 3006 3157 3.32559025674626e-06 2091 1.45905742198881 1.83126285295302 1 7.13571885809267 3157 3172 2326 2553 2158 4152 2794 3810 2091 3562 3291 3336 M13615 GO_DIOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. 6/12 Gene Ontology BP GO:0034311 2.56996997013435e-05 5.51658371305308e-05 3160 3280.81818181818 3158 2.56999969197354e-06 1874 0.622808851656478 -0.657673300437825 -1 3.14175227294538 3158 1874 4105 2857 2076 3014 3077 3892 4177 4428 3431 3337 M16193 GO_PROTEIN_TETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TETRAMERIZATION.html The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. 78/176 Gene Ontology BP GO:0051262 1.26158398795524e-05 3.01158583859957e-05 3280 2831.45454545455 3158 1.14690111139293e-06 1819 1.39752378366592 -1.09004259552906 -1 7.4849928061278 3277 2052 2341 3158 1819 2699 3280 3596 2231 3227 3466 3338 M16557 GO_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PROCESS.html The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 20/73 Gene Ontology BP GO:0050886 4.21227341958945e-05 8.41910696821086e-05 3845 2903.90909090909 3158 3.82941279352343e-06 1099 1.63182103089365 -1.1326086903473 -1 7.87679957758958 3843 1099 1785 2941 2197 3410 3550 3702 3158 3212 3046 3339 M11365 GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 26/67 Gene Ontology BP GO:0032480 0.00225739927685582 0.00322694114607191 3190 2909.18181818182 3159 0.000205428991443992 1192 0.907193782902516 -0.879789181962724 -1 2.67724459565756 3190 2500 3159 4005 3077 2071 3915 1192 3588 3599 1705 3340 M12841 GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. 9/19 Gene Ontology BP GO:0007007 0.0324922966103076 0.0409505247452927 2955 3329 3159 0.0032977396674967 2247 0.482673305747581 -0.482673305747581 -1 0.793485023249525 2955 3159 3967 3826 3472 2247 2612 3023 4106 4360 2892 3341 M16788 GO_LEUKOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. 38/87 Gene Ontology BP GO:0001776 1.30745937011363e-05 3.09784199341947e-05 3855 3309.54545454545 3159 1.1886064912778e-06 1838 1.21632037647962 -0.978702428255785 -1 6.49681497985211 3853 2137 2442 2229 1838 4195 4483 4429 3159 3077 4563 3342 M12427 GO_LEYDIG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEYDIG_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. 3/13 Gene Ontology BP GO:0033327 0.00339340642330517 0.00474995056478924 3770 2777.63636363636 3161 0.000339859943059225 214 1.08200069678532 -1.20869101306206 -1 2.9779179580702 3768 1668 3906 1364 3161 4145 3596 2315 214 2583 3834 3343 M10159 GO_NEURONAL_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_DIVISION.html The self-renewing division of a neuronal stem cell. 6/21 Gene Ontology BP GO:0036445 0.000138216858948882 0.000243175777226094 3105 3426.63636363636 3162 1.38225456456539e-05 2533 0.94259673813752 -1.05738332188716 -1 4.03553926607099 3838 2901 3545 3162 2533 3102 3048 4505 3833 3105 4121 3344 M13848 GO_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLESION_SYNTHESIS.html The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. 21/55 Gene Ontology BP GO:0019985 0.0184121443072431 0.0237531497689719 1565 2843.90909090909 3163 0.0016880062224983 1381 0.882876772840995 -0.882876772840995 -1 1.69878468528493 1561 4091 3163 4357 3770 1381 1426 1466 4236 3939 1893 3345 M14924 GO_NEUROBLAST_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_DIVISION.html The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. 6/21 Gene Ontology BP GO:0055057 0.000138216858948882 0.000243175777226094 3840 3502.09090909091 3163 1.38225456456539e-05 2534 0.94259673813752 -1.05738332188716 -1 4.03553926607099 3839 2902 4319 3163 2534 3103 3049 4506 3834 3152 4122 3346 M11275 GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper cell differentiation. 9/40 Gene Ontology BP GO:0045622 0.000248776480182737 0.000416391203132101 3860 3059.36363636364 3164 2.48804334953283e-05 1192 1.72978196679174 -1.74687536417576 -1 6.92707840246177 3860 2205 3720 3164 2656 2957 3246 4335 3066 1192 3252 3347 M11854 GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. 59/129 Gene Ontology BP GO:1901800 4.58167494611253e-07 2.78730492769333e-06 3540 2797.18181818182 3164 4.16515990934823e-08 613 1.25044989156895 -1.3287676683163 -1 8.22837253982436 3537 3542 2833 4350 613 1683 4124 1939 3164 3853 1131 3348 M15105 GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 135/306 Gene Ontology BP GO:0009123 0.00375355102624536 0.00523448175682013 1385 2945.90909090909 3165 0.000341815502018527 1384 1.15012240760067 -0.899259969424107 -1 3.10793026010088 1384 4117 3325 4055 3165 1832 1712 3174 3062 4109 2470 3349 M16876 GO_CYTOSOLIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_TRANSPORT.html The directed movement of substances or organelles within the cytosol. 125/284 Gene Ontology BP GO:0016482 4.71026123849193e-06 1.33923716658408e-05 2915 3213.09090909091 3165 4.28206483938417e-07 1536 1.32521390848345 -1.03962791867768 -1 7.65020553320163 4169 3621 2911 3165 1536 2327 3937 4403 2798 2913 3564 3350 M10692 GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER.html The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 6/16 Gene Ontology BP GO:0090557 0.0765897756730953 0.0916038970762961 3800 3234.09090909091 3166 0.00793650793650794 2237 1.43585804499691 1.43585804499691 1 1.76572289700985 2480 4045 3619 3797 3799 2966 2700 3656 3166 3110 2237 3351 M14035 GO_MITOTIC_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_CHECKPOINT.html A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. 88/191 Gene Ontology BP GO:0007093 0.0608690085214421 0.0742745877963352 2935 3413 3167 0.00569285290107128 2704 1.46809204943387 -1.27547690846317 -1 1.963750936917 2934 4471 2965 4427 3554 2704 2841 3924 2835 3721 3167 3352 M15922 GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX.html The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. 6/16 Gene Ontology BP GO:0030150 0.00344306993406769 0.00481511256140852 2245 3023.27272727273 3167 0.000344841622469069 1926 0.710536294138238 -0.710536294138238 -1 1.950580098152 2243 3234 4480 3217 3167 1932 2167 2105 4202 4583 1926 3353 M14145 GO_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT.html Any process that modulates the frequency, rate or extent of protein import. 136/325 Gene Ontology BP GO:1904589 3.11421727724992e-06 9.75026720257066e-06 3185 2971.27272727273 3169 2.83111062327202e-07 1388 1.47990880178037 -1.29901911524596 -1 8.78488221291021 3182 3169 2605 2063 1388 4522 3226 3126 2235 3455 3713 3354 M16972 GO_AMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 9/24 Gene Ontology BP GO:0009309 3.4228782027914e-06 1.05039150664643e-05 4645 3165.81818181818 3170 3.42288347504566e-07 1458 0.896697013562856 -0.878254474235868 -1 5.28853251064697 3170 1942 4643 3100 1458 2569 1805 3865 4256 4643 3373 3355 M10842 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. 35/89 Gene Ontology BP GO:0002720 0.0635943371594441 0.0774779604910256 3380 3089.90909090909 3171 0.0059555130173715 1977 1.76110309769618 -1.43319336120035 -1 2.31743183983298 3376 4123 1977 2605 3560 2510 3916 3241 3014 2496 3171 3356 M11887 GO_PHAGOLYSOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOLYSOSOME_ASSEMBLY.html The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. 13/19 Gene Ontology BP GO:0001845 0.161385165508919 0.178875942577683 2770 3175.27272727273 3171 0.0158730158730159 1632 1.02982899433429 -0.799833463090407 -1 0.911850073551735 2770 3776 2731 4448 3878 2606 1632 2751 3744 3171 3421 3357 M13571 GO_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_HOST.html An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 86/213 Gene Ontology BP GO:0051701 1.64985149891852e-06 6.2278540727469e-06 3205 2796.54545454545 3171 1.49986612381553e-07 1138 1.68807784707897 -1.48351438605943 -1 10.4098970051178 3202 3171 1353 2282 1138 3852 4611 4048 2191 1446 3468 3358 M16102 GO_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that modulates the frequency, rate or extent of muscle adaptation. 48/102 Gene Ontology BP GO:0043502 0.455189738866078 0.483811265235424 2260 3243.72727272727 3172 0.0537142545683945 1801 1.1575565244438 1.09388461892006 1 0.432390037770352 2257 4614 2594 4500 4076 2246 1801 2738 4071 3612 3172 3359 M14484 GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 120/307 Gene Ontology BP GO:0051494 0.00392054213491406 0.00545492272472459 2650 3213.18181818182 3173 0.000357049661372326 2076 1.48696144993759 1.68218983227111 1 3.98660079830839 2647 4025 2483 4297 3173 3691 2341 2076 3140 3935 3537 3360 M11916 GO_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CHEMOTAXIS.html The movement of a leukocyte in response to an external stimulus. 52/167 Gene Ontology BP GO:0030595 3.18165968690924e-05 6.57214512427841e-05 3370 3057.81818181818 3174 2.89245972844363e-06 680 1.93941651387383 -1.79224427514063 -1 9.60867612091147 3368 3174 680 2943 2119 4546 4167 4632 2830 1182 3995 3361 M13789 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. 14/27 Gene Ontology BP GO:0034198 0.0454424471121073 0.0562338171485912 2095 3007.27272727273 3174 0.00421901495862293 1096 0.649930681160054 -0.649930681160054 -1 0.962399172904158 2093 3944 3174 4353 4119 1096 1132 2030 4467 4439 2233 3362 M14061 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. 34/86 Gene Ontology BP GO:0032106 1.39894800108041e-06 5.59940997328994e-06 4070 2833.63636363636 3174 1.27177171877444e-07 795 0.922367278181634 -0.812477901003566 -1 5.73845281573292 4068 795 2702 1978 1067 2356 4196 4007 3174 3614 3213 3363 M16372 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. 34/86 Gene Ontology BP GO:0032109 1.39894800108041e-06 5.59940997328994e-06 4070 2834.36363636364 3175 1.27177171877444e-07 796 0.922367278181634 -0.812477901003566 -1 5.73845281573292 4069 796 2703 1979 1068 2357 4197 4003 3175 3617 3214 3364 M11823 GO_NAD_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 32/75 Gene Ontology BP GO:0019674 0.0382017052741154 0.047680246663365 2870 3050.54545454545 3176 0.00353469485545854 1608 1.19221783531108 -1.25339516145045 -1 1.86660990568954 2869 3176 2891 3351 3482 1797 3271 4438 3147 3526 1608 3365 M13309 GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 production. 28/103 Gene Ontology BP GO:0032652 0.0839184282471183 0.0949861682962873 3310 2889.18181818182 3176 0.00793650793650794 1843 1.43445487492796 1.57475580545792 1 1.73723979283016 3306 3034 1936 2600 3636 3760 1843 3176 3353 1950 3187 3366 M15816 GO_PYRUVATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRUVATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. 29/83 Gene Ontology BP GO:0006090 0.0839184282471183 0.0949861682962873 3710 3122.45454545455 3176 0.00793650793650794 2002 1.54108538867827 -1.41955108449848 -1 1.86637801403107 3242 3544 2527 3176 3709 2783 4102 2479 3073 3710 2002 3367 M16487 GO_ADIPOSE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADIPOSE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. 23/50 Gene Ontology BP GO:0060612 0.000614129442715528 0.00096103909758281 3485 3107.72727272727 3176 5.58455403474478e-05 1902 1.47205298140018 -1.2585502825008 -1 5.26155345924486 3176 3038 2238 3484 2806 3561 3701 3667 3128 1902 3484 3368 M10596 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. 17/29 Gene Ontology BP GO:1902108 3.22266864850941e-05 6.64424979352983e-05 4470 3331 3178 2.92974168792677e-06 2125 1.27247947426835 -1.0116729247737 -1 6.29724874870436 4468 2982 2751 3178 2125 3661 3900 4244 3173 2319 3840 3369 M11831 GO_MRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. 5/13 Gene Ontology BP GO:0016556 0.00240604720253839 0.00342887574014295 1920 2748.90909090909 3180 0.000240865625758583 981 0.834014641732482 -0.834014641732482 -1 2.43523941413133 1916 3330 3814 3180 4062 981 1427 1014 4412 4289 1813 3370 M12063 GO_PEPTIDYL_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_AMINO_ACID_MODIFICATION.html The alteration of an amino acid residue in a peptide. 446/1025 Gene Ontology BP GO:0018193 4.86902476836218e-07 2.86654203278225e-06 2830 3159.36363636364 3180 4.42638713270155e-08 639 1.42429673388125 1.59314334852327 1 9.35180205349851 2827 4513 3180 4249 639 4585 2301 3232 2682 3666 2879 3371 M13749 GO_POSITIVE_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_URINE_VOLUME.html Any process that increases the amount of urine excreted from the body over a unit of time. 9/17 Gene Ontology BP GO:0035810 0.00385446433764111 0.00536784772880366 3115 3032.36363636364 3181 0.000386116630691638 1276 3.49056505434171 -3.22947859272512 -1 9.38723832074898 3113 3126 4127 1613 3181 3628 3238 3432 1276 2689 3933 3372 M10038 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION.html The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. 8/46 Gene Ontology BP GO:0050908 0.00391701396970615 0.00545164744045133 4270 3046.63636363636 3182 0.00039239354959345 1050 1.69599728030548 -1.90399651286129 -1 4.54755818700406 4269 2367 3522 2192 3182 4556 2581 3400 2176 1050 4218 3373 M14779 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. 8/46 Gene Ontology BP GO:0050962 0.00391701396970615 0.00545164744045133 4270 3118.45454545455 3183 0.00039239354959345 1059 1.69599728030548 -1.90399651286129 -1 4.54755818700406 4270 2368 4291 2193 3183 4557 2582 3404 2177 1059 4219 3374 M15637 GO_PEPTIDE_HORMONE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_PROCESSING.html The generation of a mature peptide hormone by posttranslational processing of a prohormone. 10/44 Gene Ontology BP GO:0016486 3.88645688333068e-05 7.85924185945312e-05 4195 3126.90909090909 3183 3.53320503823732e-06 2087 1.26138726826889 -0.782823153607934 -1 6.13337210258809 3393 2237 2419 4066 2175 4191 3780 2672 3183 2087 4193 3375 M16177 GO_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 13/24 Gene Ontology BP GO:0070227 8.405675298043e-05 0.000155179126874011 4185 3291.63636363636 3183 7.6418149782079e-06 2035 0.903231489726587 0.841243626097634 1 4.07574468823775 4183 3042 2893 2415 2387 3771 4479 2035 3725 3183 4095 3376 M14205 GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a myeloid leukocyte. 24/91 Gene Ontology BP GO:0002444 0.0683381770912047 0.0830830469323025 2355 2897.81818181818 3185 0.00641437415068477 1751 1.85987414555317 2.69589140662391 1 2.38057096947808 2354 3430 2118 3223 4293 3557 1751 1826 3185 3448 2691 3377 M14537 GO_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. 116/208 Gene Ontology BP GO:0007033 5.78673077375891e-07 3.16463969170349e-06 2840 2729 3185 5.2606657235108e-08 720 1.07602099603636 -1.06522320249656 -1 7.01028745713784 2837 2213 3294 3680 720 1430 3185 3270 3218 3626 2546 3378 M12244 GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE.html Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. 9/12 Gene Ontology BP GO:0048875 0.00417817717764089 0.00579948479395714 4060 2925.27272727273 3187 0.000418605375250483 1054 1.82465644729006 -1.99232484049179 -1 4.83447626825785 4058 2073 3874 2314 3187 3933 4541 2085 1054 1197 3862 3379 M16234 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 220/537 Gene Ontology BP GO:0010639 0.0839184282471183 0.0949861682962873 2135 3269.09090909091 3187 0.00793650793650794 2098 1.36962576297123 1.54937098206624 1 1.65872646765075 2131 4320 3048 4191 4049 3426 2400 2098 3187 4081 3029 3380 M12136 GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 10/22 Gene Ontology BP GO:0002082 0.0783801523626057 0.0936487512659748 1740 3030.54545454545 3188 0.00739276113046713 1371 0.521781820512482 -0.521781820512482 -1 0.635725089915203 1740 4069 3188 3669 4355 1371 1580 2707 4500 4311 1846 3381 M12178 GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 13/29 Gene Ontology BP GO:0034243 0.214413956345283 0.234904199931842 3190 3126.18181818182 3188 0.0216997602807795 1379 0.714790458003241 -0.577531119653884 -1 0.532698563690691 3188 3291 3040 3818 4057 1922 1379 2625 4405 4318 2345 3382 M12431 GO_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MEMBRANE.html A process in which a protein is transported to, or maintained in, a specific location in a membrane. 223/589 Gene Ontology BP GO:0072657 0.000136170072301052 0.00023984736179582 4290 3117.27272727273 3190 1.23798637585876e-05 1536 1.46592203446034 -1.29979627028628 -1 6.28644663723945 4288 3138 3198 1674 2502 1900 3913 4546 1536 3190 4405 3383 M11930 GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. 6/29 Gene Ontology BP GO:0045947 0.0232780056851151 0.0297167391795407 3050 3301.18181818182 3191 0.00235255018353676 2349 0.198333594699112 -0.342575215278133 -1 0.358765818209621 3047 3452 3827 3191 3423 2349 3167 2515 4468 4300 2574 3384 M14235 GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 9/20 Gene Ontology BP GO:0010745 0.0332846524771049 0.0418809326426012 1840 2839.18181818182 3191 0.00337939628680277 843 1.89246046053573 1.89246046053573 1 3.08921934751594 1840 3191 4211 3470 4606 1703 843 1913 4089 3503 1862 3385 M10393 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM.html A process in which an organism has a negative effect on the functioning of the second organism's cells. 9/82 Gene Ontology BP GO:0044364 0.0765897756730953 0.0916038970762961 2775 3189.81818181818 3192 0.00793650793650794 2203 1.47126049052169 -0.949770503685069 -1 1.80925851560988 2771 3192 3578 2903 4089 3697 2638 3372 3169 3476 2203 3386 M15175 GO_LIPOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving liposaccharide. 52/115 Gene Ontology BP GO:1903509 1.0422903192597e-06 4.52699153631691e-06 3910 3077.36363636364 3192 9.47537102785605e-08 962 1.13701444502662 -0.919269582303568 -1 7.19823296607663 3910 2832 2799 3553 962 3000 3372 3488 2948 3192 3795 3387 M11320 GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM.html Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 9/82 Gene Ontology BP GO:0031640 0.0765897756730953 0.0916038970762961 2775 3202.09090909091 3193 0.00793650793650794 2204 1.47126049052169 -0.949770503685069 -1 1.80925851560988 2772 3193 3730 2904 4090 3698 2639 3340 3170 3483 2204 3388 M12400 GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY.html The disaggregation of a macromolecular complex into its constituent components. 135/249 Gene Ontology BP GO:0032984 0.00197705679316794 0.00284458465778703 2045 3079 3193 0.00017989415798857 2045 1.10730438150446 -0.834408182678007 -1 3.3396432978254 2045 3199 3371 3144 3056 2389 2785 3193 3281 4068 3338 3389 M14071 GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 47/90 Gene Ontology BP GO:0071479 0.0417910847350947 0.0519507379986733 2580 3187.90909090909 3193 0.00387333832540156 1684 2.0557400510129 2.97397802396347 1 3.1278733613766 2736 4280 2874 3984 3504 3672 2577 1684 2577 3986 3193 3390 M12917 GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. 8/17 Gene Ontology BP GO:0006044 0.113197135818313 0.127103821427914 1060 2837.90909090909 3194 0.0119413860612871 1059 0.953608298860734 0.953608298860734 1 1.01199537297304 1059 3194 3980 3250 3687 1960 1157 2702 4224 3384 2620 3391 M10241 GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 8/21 Gene Ontology BP GO:0051532 0.00200813355756214 0.00288750824024806 3710 2902.09090909091 3195 0.000200995053903081 783 1.73576215589576 -1.73576215589576 -1 5.22170606423595 3707 2362 3558 2651 3195 3898 4477 979 783 3362 2951 3392 M14442 GO_MITOCHONDRIAL_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FUSION.html Merging of two or more mitochondria within a cell to form a single compartment. 11/23 Gene Ontology BP GO:0008053 0.0839184282471183 0.0949861682962873 2800 3296.18181818182 3195 0.00793650793650794 2205 0.936457813048449 -0.936457813048449 -1 1.13412486378661 2798 3745 3195 4351 3676 2393 2205 3092 3637 4481 2685 3393 M11662 GO_TRANSLATIONAL_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_TERMINATION.html The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). 62/100 Gene Ontology BP GO:0006415 0.048074398978757 0.0593958048053137 380 2695.63636363636 3196 0.00446892970454561 380 0.657428857525589 -0.626421077817475 -1 0.954999351275761 380 3363 3488 3196 3521 1355 1764 2260 3757 4282 2286 3394 M12648 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation. 16/54 Gene Ontology BP GO:0002577 0.0305801463748798 0.0386560358340775 3615 3138.36363636364 3196 0.00281942479517617 1500 2.02320490763902 2.23634750900872 1 3.38604806998048 3611 3095 1500 3060 3441 4370 3309 3196 2939 1616 4385 3395 M15071 GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. 6/23 Gene Ontology BP GO:0046321 0.0139671517481098 0.0182263871743884 1770 3036.72727272727 3196 0.00140557228440122 1522 0.758479313772085 0.758479313772085 1 1.56277236986619 1767 3196 4343 3268 3353 2344 1522 2347 4203 4521 2540 3396 M13951 GO_INTERSTRAND_CROSS_LINK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTRAND_CROSS_LINK_REPAIR.html Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. 25/49 Gene Ontology BP GO:0036297 0.314790936505597 0.339269804595053 1565 3223.72727272727 3197 0.0337826600347348 1565 0.582547406423865 -0.612426411016314 -1 0.323967090959906 1565 3737 3197 4362 3832 2205 2439 2655 4195 4447 2827 3397 M14393 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 26/56 Gene Ontology BP GO:0032206 0.0853724867340168 0.0965613778090231 2145 3130 3197 0.00807976236305591 1202 0.767378161299257 -0.843464854610554 -1 0.92286224125384 2143 4240 3139 4181 4379 1299 1202 3197 4312 3990 2348 3398 M14622 GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of guanylate cyclase activity. 8/14 Gene Ontology BP GO:0031282 2.39894199840595e-05 5.20237631882243e-05 4310 3108.09090909091 3197 2.39896789595162e-06 1213 1.32830541412408 -1.17259492833427 -1 6.74069914358035 4307 1213 4261 1650 2044 3703 3044 4082 3197 2535 4153 3399 M11124 GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that activates or increases the frequency, rate or extent of viral genome replication. 20/50 Gene Ontology BP GO:0045070 0.0548655982864382 0.0673739679566074 2455 3099.36363636364 3199 0.0051166955762511 1497 1.31170130760412 -1.23320662710256 -1 1.82036243151228 2454 4559 2600 4461 4353 1537 1497 3668 4034 3199 1731 3400 M12441 GO_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGY.html The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. 267/578 Gene Ontology BP GO:0006914 3.72537247644149e-07 2.55493418140588e-06 3865 3004.18181818182 3199 3.38670282479818e-08 507 1.46358471872852 -1.22280832243779 -1 9.69641570220872 3865 3080 2788 4447 507 1666 3715 3658 2214 3907 3199 3401 M13287 GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. 8/15 Gene Ontology BP GO:0032354 0.000625331479761427 0.00097593749933859 3525 2869.09090909091 3199 6.25507517240695e-05 1215 2.05902606048688 -1.68725121457601 -1 7.34327391695349 3523 1718 4043 1437 2836 4080 3199 4554 1215 1744 3211 3402 M13931 GO_REGULATION_OF_PROTEIN_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_STABILITY.html Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. 134/304 Gene Ontology BP GO:0031647 2.99620280054157e-06 9.48933806474385e-06 3090 2895 3202 2.72382443737181e-07 1107 1.30504465265556 -1.3902845369838 -1 7.7650840145546 3087 4527 3202 4042 1374 1147 4052 2216 3216 3875 1107 3403 M10830 GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mitochondrial DNA. 11/18 Gene Ontology BP GO:0032042 0.00503127738093939 0.00693181628477792 2760 3295 3203 0.000458438237003318 2603 0.580461050015293 -0.559226929601774 -1 1.48468425198674 2759 2865 3071 3863 3203 2747 3437 3491 3984 4222 2603 3404 M11514 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION.html A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. 14/25 Gene Ontology BP GO:0000132 0.0459766481900243 0.0568797169054844 2320 2977.27272727273 3204 0.00426968885346379 1706 1.66598372231811 1.66598372231811 1 2.45715617292416 2316 3403 2568 3295 3722 3453 3204 1706 2757 3237 3089 3405 M13441 GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. 20/46 Gene Ontology BP GO:0038034 0.0030920506248008 0.00434647019405089 4555 3426.81818181818 3204 0.000281491363903966 2505 1.22291069621903 -1.04926722151074 -1 3.42158543552346 4555 2505 2804 2783 3129 3623 3698 4346 2932 3204 4116 3406 M13439 GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. 49/123 Gene Ontology BP GO:0006767 0.000205637194398253 0.000350632939254898 3665 3165.27272727273 3205 1.86960380110056e-05 1995 1.52771130519053 1.58842393282213 1 6.25296276752436 3663 3205 2003 3854 2591 4263 3568 2642 2664 1995 4370 3407 M14423 GO_I_KAPPAB_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_PHOSPHORYLATION.html The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 20/54 Gene Ontology BP GO:0007252 3.88298777038604e-06 1.14979032001928e-05 3965 3201.36363636364 3206 3.52999511259527e-07 1476 1.16124465666346 0.827795605545424 1 6.79476248956371 3965 2787 2811 2347 1476 4548 3838 3421 2308 3206 4508 3408 M16612 GO_REGULATION_OF_GONADOTROPIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GONADOTROPIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. 2/14 Gene Ontology BP GO:0032276 0.00931738246026728 0.0124276376796958 2800 3114.6 3206.5 0.00103957713065485 1776 2.48821793095678 2.48821793095678 1 5.61695226567087 2797 1776 4592 NA 3318 3485 3569 3095 3640 2297 2577 3409 M14700 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. 20/46 Gene Ontology BP GO:0097192 0.0030920506248008 0.00434647019405089 4560 3428.18181818182 3207 0.000281491363903966 2506 1.22291069621903 -1.04926722151074 -1 3.42158543552346 4556 2506 2805 2784 3130 3624 3699 4349 2933 3207 4117 3410 M10903 GO_PHOSPHOLIPID_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 19/34 Gene Ontology BP GO:0046839 0.000166832988545544 0.00028795745941151 3685 3274 3208 1.51677855785777e-05 2095 1.33394328935123 -1.15666095559224 -1 5.59501162700685 3681 4191 2954 3807 2560 2629 3938 4396 2095 2555 3208 3411 M14803 GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 20/51 Gene Ontology BP GO:0046685 0.0640690118142088 0.0780357874746515 2510 3055.18181818182 3208 0.00600133197829355 1793 1.02118128186701 -0.896248436839878 -1 1.34000056661642 2509 3660 2694 4450 3644 1921 3301 2482 3945 3208 1793 3412 M11708 GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/16 Gene Ontology BP GO:0032239 0.232084910217807 0.253725038413298 2970 3270 3209 0.0260619793682361 1795 1.16487974930135 1.16487974930135 1 0.82193928388884 2968 3892 3793 4006 4252 2952 1795 3209 4098 2675 2330 3413 M11709 GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glutathione derivative. 13/28 Gene Ontology BP GO:1901687 0.000874779286044149 0.00132732033500097 2960 3280.45454545455 3209 7.95570286925214e-05 2745 1.03731831462198 -1.08976998599291 -1 3.53535853267072 2959 3344 2745 3736 2897 3095 3283 4112 3536 3169 3209 3414 M14912 GO_TETRAHYDROFOLATE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_INTERCONVERSION.html The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. 6/13 Gene Ontology BP GO:0035999 0.0725263637362381 0.0880365769483277 2660 3269.90909090909 3209 0.00750081833676302 2210 1.22413991473581 1.22413991473581 1 1.53038178230478 2658 2210 4315 2757 3589 3209 3083 3812 3676 3151 3509 3415 M15692 GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 26/54 Gene Ontology BP GO:0006213 0.000931896414478361 0.00140617323770654 4120 3325.27272727273 3209 8.47537627326548e-05 2190 1.57446544949006 2.25064922461055 1 5.31930273286304 4119 3209 2190 3149 2912 3019 3340 4032 2543 3606 4459 3416 M12449 GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione derivative. 13/28 Gene Ontology BP GO:1901685 0.000874779286044149 0.00132732033500097 2960 3281.27272727273 3210 7.95570286925214e-05 2746 1.03731831462198 -1.08976998599291 -1 3.53535853267072 2960 3345 2746 3737 2898 3096 3284 4109 3537 3172 3210 3417 M16153 GO_GLYCEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROL_TRANSPORT.html The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. 7/11 Gene Ontology BP GO:0015793 0.0047871443978939 0.00660919162635189 4345 3328.09090909091 3213 0.000479748831113689 1986 3.56895025600191 -3.54679132496305 -1 9.21606347120992 4344 2450 4519 1986 3213 4239 2762 3584 2993 2407 4112 3418 M16281 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. 46/94 Gene Ontology BP GO:1901989 0.0839184282471183 0.0949861682962873 2850 3317.36363636364 3213 0.00793650793650794 2090 1.47090935356384 1.69989330673267 1 1.7813891302034 2848 4479 2363 4294 4431 3627 2614 2090 2956 3213 3576 3419 M11076 GO_MACROMOLECULE_DEACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_DEACYLATION.html The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. 35/70 Gene Ontology BP GO:0098732 0.00671900305747618 0.00910575925156507 3050 2973.09090909091 3214 0.000612691971262822 1822 1.09440147907393 -1.03606928070862 -1 2.64563679161329 3050 3681 3130 3214 3252 1837 3286 2699 3423 3310 1822 3420 M16719 GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 18/72 Gene Ontology BP GO:0060119 5.45219290460831e-05 0.000105737905017598 4175 3141 3214 4.95666184484595e-06 1843 1.74918709568715 -1.85659186550526 -1 8.23825922733439 4171 3214 1843 3031 2271 3836 3820 3437 2516 1886 4526 3421 M15197 GO_GLYCEROLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. 18/46 Gene Ontology BP GO:0046503 0.0185990851215722 0.0239676803273549 2760 2985.90909090909 3215 0.00170529189003197 1437 1.8038803639307 2.16414595479861 1 3.46258853646689 2760 3215 1437 3554 3380 4038 3445 2159 3108 1879 3870 3422 M11959 GO_HEXOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 27/78 Gene Ontology BP GO:0019320 0.0839184282471183 0.0949861682962873 4150 3181.45454545455 3216 0.00793650793650794 2515 1.42279910095335 -1.3449581181684 -1 1.72312370293374 4149 3575 2537 3360 3616 2515 2869 3283 2862 3216 3014 3423 M11982 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 27/45 Gene Ontology BP GO:0071353 0.0320328287124974 0.0404263179429534 3785 3134.09090909091 3217 0.0029553612275862 1900 1.44420020869155 -1.30217464111875 -1 2.38375160542987 3782 3710 1900 3876 3445 2780 3148 2654 3275 3217 2688 3424 M10598 GO_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_PROTEIN_TRANSPORT.html The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. 469/1034 Gene Ontology BP GO:0006886 0.0166435696732811 0.0215794733295292 2200 2996.36363636364 3219 0.00152462113928847 861 1.18405319948278 -1.15139691870998 -1 2.33675593944116 2197 4317 3496 4385 3456 861 2603 2787 3219 4126 1513 3425 M13355 GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 27/57 Gene Ontology BP GO:0090199 1.59884335665753e-05 3.67860738600639e-05 4160 3047.90909090909 3219 1.4535045239287e-06 1204 1.79009862243663 -0.989486394199041 -1 9.40332996973642 4158 3091 2333 3232 1895 4199 3670 2028 1204 3219 4498 3426 M12111 GO_INNER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 15/63 Gene Ontology BP GO:0036159 0.000158330362739257 0.000274600050560851 4485 3117.09090909091 3220 1.43947053329015e-05 1464 1.23774190427737 0.732991650823237 1 5.22175560012175 4481 3220 2646 2481 2545 4211 4234 1464 2429 3333 3244 3427 M13690 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER.html The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. 12/39 Gene Ontology BP GO:0048791 0.000254099700367886 0.000424077968658553 2360 3070.63636363636 3221 2.31026412359265e-05 1818 1.44541549642131 -1.40002944955675 -1 5.7747027105175 3632 2360 1818 3443 2643 3221 3960 4115 3514 2356 2715 3428 M15731 GO_PHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 13/34 Gene Ontology BP GO:0009395 5.03529388759639e-05 9.87700444449093e-05 4625 3190.36363636364 3221 4.5776446705297e-06 1836 1.85173372800247 -2.01214399878041 -1 8.78617221160273 4621 3221 1836 2980 2248 4258 3748 4630 1890 1855 3807 3429 M13272 GO_PROTEIN_AUTOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOUBIQUITINATION.html The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. 27/55 Gene Ontology BP GO:0051865 0.0979167257044959 0.110400038233602 3225 3345 3223 0.00932429673761976 1926 1.00623163025432 -1.00623163025432 -1 1.14077850766221 3223 4431 3073 4411 4609 2888 1926 1951 4142 3864 2277 3430 M14044 GO_REGULATION_OF_MITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOPHAGY.html Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy). 34/62 Gene Ontology BP GO:1903146 0.0158349150432557 0.0205827297160796 2085 2870.45454545455 3223 0.00145000470191111 1022 0.981220126438746 1.23091278549675 1 1.96033257751466 2084 3962 3223 4306 3381 2806 1022 1420 3413 3825 2133 3431 M13567 GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. 6/12 Gene Ontology BP GO:0008655 0.022809472719559 0.0291506693743222 1865 2889.63636363636 3225 0.00230470342163334 979 0.793694991344058 -0.793694991344058 -1 1.4435739753925 1863 2874 4098 3677 3417 1303 979 3225 4254 4421 1675 3432 M13633 GO_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIVISION.html Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. 152/381 Gene Ontology BP GO:0051302 7.77462777920579e-08 1.04934874357129e-06 3225 3042 3225 7.06784368541371e-09 71 1.68596704179343 -1.30272487290559 -1 11.9415718620721 4362 3677 1528 3224 71 3149 3911 4020 2319 3225 3976 3433 M15970 GO_RESPONSE_TO_COBALT_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COBALT_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. 9/17 Gene Ontology BP GO:0032025 0.00317431700002124 0.00445402049897208 4625 3363.36363636364 3226 0.000317886046665984 2386 1.28319899517942 1.43717124410165 1 3.57412969903433 4623 2411 4489 2516 3150 3226 2386 3453 2701 3513 4529 3434 M16008 GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of ARF protein signal transduction. 8/16 Gene Ontology BP GO:0032012 0.00501168424604532 0.00690687146167659 3900 3085.27272727273 3226 0.000502302289278574 1302 1.60688622146774 -2.62666682910924 -1 4.11302421761659 3897 3128 4493 2315 3226 4219 1655 3876 1302 3405 2422 3435 M16119 GO_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. 61/185 Gene Ontology BP GO:0006766 3.74052917069628e-05 7.59723400679914e-05 4645 3240.45454545455 3226 3.40053888200295e-06 1774 1.58755999209048 -1.64130315615511 -1 7.7470483459979 4641 3570 1906 4391 2162 2588 4075 4615 2697 1774 3226 3436 M12604 GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER.html The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. 12/41 Gene Ontology BP GO:0060795 6.36107438260101e-05 0.000121163379006912 3230 3150.09090909091 3227 5.78296210362618e-06 1114 2.20441964070415 -3.12091694910989 -1 10.2278581356081 3227 1114 2159 2213 2318 4440 4166 4447 3690 3047 3830 3437 M14295 GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 12/34 Gene Ontology BP GO:0055094 0.00561610740560183 0.00768964514426697 3070 3149.81818181818 3227 0.00051186322892166 1674 1.84406701553551 -2.08235316346649 -1 4.61826527724096 3068 2813 1674 3574 3227 3383 2260 3729 3980 3054 3886 3438 M11658 GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. 11/35 Gene Ontology BP GO:0046471 0.00802904854391972 0.0107804720617175 2970 2971.36363636364 3228 0.000732591063344584 930 2.43624335625953 -0.486308245397195 -1 5.67783762473534 2967 4132 2337 3861 3749 3967 3228 1250 930 3647 2617 3439 M16136 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT.html The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 27/55 Gene Ontology BP GO:1901264 3.66885387155501e-06 1.10470094199934e-05 4500 3162.54545454545 3228 3.33532726361205e-07 914 0.905616452112208 -0.656996307858955 -1 5.31764995281727 4497 914 2888 2031 1447 3981 4165 4284 3228 3222 4131 3440 M16866 GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. 8/14 Gene Ontology BP GO:0046498 0.00272184393869582 0.0038587851625541 3240 2967.09090909091 3228 0.000272518349246419 931 1.48545349562568 -2.01438358361348 -1 4.24710679972706 3237 3228 4627 2749 3120 3384 3621 1867 931 3410 2464 3441 M13815 GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. 53/135 Gene Ontology BP GO:0046434 1.721153026958e-05 3.92115481068007e-05 3965 3328.63636363636 3229 1.56469681128491e-06 1918 1.34316144453576 -1.1817624884618 -1 7.01146008150946 3963 3589 2389 4483 1918 2737 3901 4338 3229 2884 3184 3442 M14399 GO_GDP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. 7/17 Gene Ontology BP GO:0046710 0.00358343973589865 0.00500840177416539 1460 2639.72727272727 3229 0.000358923135252025 970 0.68981701920642 -0.68981701920642 -1 1.87973339073686 1456 3506 4234 3229 3390 1368 970 1232 4204 4476 972 3443 M15508 GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. 15/31 Gene Ontology BP GO:0006760 0.00566476681653157 0.00774485050917435 3925 3091 3230 0.000516309617203943 1153 1.90838740545371 1.44853616387183 1 4.77232532063351 3922 2278 2203 2703 3230 4245 4551 3407 1153 2123 4186 3444 M15825 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION.html The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. 15/30 Gene Ontology BP GO:0040001 0.0839184282471183 0.0949861682962873 3225 3150.90909090909 3230 0.00793650793650794 1935 1.66598372231811 1.66598372231811 1 2.01764005028999 2223 3688 2511 3347 4463 3477 3230 1935 3223 3342 3221 3445 M12234 GO_GPI_ANCHOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GPI_ANCHOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. 16/33 Gene Ontology BP GO:0006505 0.000886557254671256 0.00134387376214125 2935 3384.54545454545 3231 8.06286110644356e-05 2540 0.635224350989937 -0.565475051729428 -1 2.16090227463758 2933 2557 3231 3810 2901 2540 4632 3480 4147 4321 2678 3446 M15215 GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. 6/11 Gene Ontology BP GO:0070525 0.0507339444825069 0.0625319098041623 1660 2880.45454545455 3231 0.00519308567692445 1477 0.866973501282713 -0.866973501282713 -1 1.23644026174181 1658 3231 4370 3511 3568 1784 1477 2331 3484 4533 1738 3447 M14101 GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 9/18 Gene Ontology BP GO:0046475 0.000246206952782322 0.000412834554629224 3355 3066.18181818182 3232 2.46234235075194e-05 1594 1.60359675454877 1.69132345722454 1 6.42883460025476 3352 1988 4187 2571 2653 4177 3232 1594 3647 1918 4409 3448 M13407 GO_REGULATION_OF_FEVER_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEVER_GENERATION.html Any process that modulates the rate or extent of fever generation. 3/13 Gene Ontology BP GO:0031620 0.0144941702517885 0.0188875757729593 3500 3089.63636363636 3233 0.00145895837229597 2178 2.83367012658679 -2.83367012658679 -1 5.78655565795606 3497 2488 4069 2178 3358 3822 3369 3233 2546 2587 2839 3449 M13838 GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. 34/140 Gene Ontology BP GO:0050829 0.000214522800707722 0.000364277714311361 2945 3109.63636363636 3233 1.95039747054709e-05 1864 1.49485712297962 1.27618931020472 1 6.08912946522449 2943 3397 1864 3547 2604 3114 2707 3528 3545 3233 3724 3450 M14090 GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. 4/18 Gene Ontology BP GO:0070296 0.0052625257204812 0.00723538848688013 4090 3081.72727272727 3233 0.000527502979551637 1451 1.22270538880147 -1.34828014132628 -1 3.10043523611762 4086 1451 4183 2495 3233 3842 1774 2863 3932 1707 4333 3451 M14337 GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE.html Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. 6/12 Gene Ontology BP GO:0043097 0.022809472719559 0.0291506693743222 1865 2906.81818181818 3234 0.00230470342163334 980 0.793694991344058 -0.793694991344058 -1 1.4435739753925 1864 2875 4226 3678 3418 1304 980 3234 4255 4465 1676 3452 M16324 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. 22/51 Gene Ontology BP GO:0019883 0.0839184282471183 0.0949861682962873 2315 3159 3235 0.00793650793650794 2311 1.93716980637674 -1.26958538923714 -1 2.3460684454844 3235 3599 2314 2885 3896 2437 3470 4458 2812 2311 3332 3453 M14797 GO_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_REACTION.html The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. 6/28 Gene Ontology BP GO:0007340 1.89375165718192e-06 6.83723868141184e-06 4260 3037.63636363636 3236 1.89375327101675e-07 1224 1.42023050668216 -1.03913849811777 -1 8.68994861176788 4256 1993 4293 2354 1224 4636 3236 3265 1795 2195 4167 3454 M15339 GO_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G2_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. 22/46 Gene Ontology BP GO:0031572 0.125022293416856 0.140110670609332 2865 3178.90909090909 3237 0.0120681227269998 2219 1.03727485879132 0.768953932958304 1 1.04879215651869 2862 3548 2713 3322 3664 2551 2219 3237 3913 3738 3201 3455 M15483 GO_CELL_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_RECOGNITION.html Cell recognition between cells. May involve the formation of specialized cell junctions. 42/135 Gene Ontology BP GO:0009988 2.5867516847407e-06 8.51793480301494e-06 4335 3291.63636363636 3237 2.35159520567142e-07 1321 1.37337866321054 -1.20163769609435 -1 8.24798059282762 4331 4057 2071 4365 1321 3237 3859 3581 3232 2954 3200 3456 M15771 GO_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_CHECKPOINT.html A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. 126/269 Gene Ontology BP GO:0000075 0.0839184282471183 0.0949861682962873 2630 3362.54545454545 3237 0.00793650793650794 2630 1.38616701263185 -1.31840594358126 -1 1.67875926579158 2630 4363 3067 3988 3623 2706 2890 3473 3237 3927 3084 3457 M11871 GO_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROAUTOPHAGY.html The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. 182/417 Gene Ontology BP GO:0016236 9.27106121033499e-07 4.19986475613013e-06 3910 2689.36363636364 3238 8.42824101570234e-08 913 1.63877178656437 -1.4129683532862 -1 10.4380059678348 3907 2129 1920 3436 913 1684 4090 3345 1570 3351 3238 3458 M12834 GO_FEAR_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEAR_RESPONSE.html The response of an organism to a perceived external threat. 10/47 Gene Ontology BP GO:0042596 0.0188700971026017 0.0243034288064853 3240 2938.63636363636 3238 0.00173035659723492 1472 1.6074246528129 2.00544446301405 1 3.07398302982505 3238 4500 2214 3521 3907 3596 2178 1472 2001 3579 2119 3459 M12290 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY.html Any process that modulates the activity of the enzyme lipoprotein lipase. 5/17 Gene Ontology BP GO:0051004 0.0765897756730953 0.0916038970762961 3565 2778 3239 0.00793650793650794 728 1.50546186070001 -1.87755216700183 -1 1.85131713008156 3563 728 3885 1915 4136 3468 4176 2613 860 1975 3239 3460 M16464 GO_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLATION.html The covalent attachment of a mannose residue to a substrate molecule. 16/31 Gene Ontology BP GO:0097502 0.000195730928485549 0.000334601878114287 3240 3298.18181818182 3239 1.77953040511186e-05 2584 0.714037366277777 -0.561699912174943 -1 2.93976449127673 3239 2983 3238 3459 2584 2674 3760 4049 3571 3842 2881 3461 M10560 GO_REGULATION_OF_PROSTAGLANDIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROSTAGLANDIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. 10/18 Gene Ontology BP GO:0032306 0.00249418031936862 0.00354685427957994 3410 3172.54545454545 3241 0.000227001137600257 1695 0.901408783938297 -0.597542118573987 -1 2.61633566103089 3241 3406 2667 2999 3093 3959 3168 1695 3699 3564 3407 3462 M14959 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 50/103 Gene Ontology BP GO:0043620 0.00035776410166917 0.000580195153353111 3005 3258.63636363636 3241 3.25292995030004e-05 2184 1.44440248884644 -1.28490389526647 -1 5.5377311356864 3001 3732 2478 3241 2705 4128 4174 2540 2184 3668 3994 3463 M16645 GO_ORGANELLE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_DISASSEMBLY.html The disaggregation of an organelle into its constituent components. 121/263 Gene Ontology BP GO:1903008 0.000236875274504846 0.00039877153717404 3570 3121.18181818182 3242 2.1536434804369e-05 1178 1.8270219032458 -1.43103781220242 -1 7.35712550721324 3570 3083 1558 3242 2626 4171 3757 4613 1178 2755 3780 3464 M10305 GO_URETER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_URETER_DEVELOPMENT.html The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. 6/21 Gene Ontology BP GO:0072189 2.30245468740216e-06 7.87789028268845e-06 3885 2560.63636363636 3243 2.30245707298956e-07 483 1.70641549473037 -1.60492702207648 -1 10.3166477134625 3885 483 3564 927 1304 4523 4290 3243 693 1294 3961 3465 M13981 GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphatidylinositol. 13/23 Gene Ontology BP GO:0046856 0.0105692677525481 0.0139729812571415 2915 3260.72727272727 3243 0.000965489902731634 2320 0.872695360079577 -1.03228298181716 -1 1.91741719392321 2914 4248 3243 3605 3306 2320 3540 2919 3804 3179 2790 3466 M13386 GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 64/164 Gene Ontology BP GO:0016051 5.17594712747667e-06 1.4428358505804e-05 3585 3047 3244 4.70541754998578e-07 1571 1.57900956731408 -1.45977853467124 -1 9.05479044600724 3583 2618 2008 3244 1571 4491 3356 3769 2145 2269 4463 3467 M11455 GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 18/28 Gene Ontology BP GO:0033014 0.0023776630097515 0.00338946556778514 2955 3239.18181818182 3245 0.000216385143446455 1831 1.73936216062459 -0.975254497334946 -1 5.08911020235317 2952 4063 3245 3838 3084 1831 2783 3750 3766 3888 2431 3468 M15218 GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. 9/17 Gene Ontology BP GO:0034314 0.0010646964631431 0.0015890021466967 2775 2930.36363636364 3245 0.000106520691773159 854 1.28143709827742 -1.28143709827742 -1 4.24872679548827 2773 3640 4371 2982 3245 2550 3371 854 3310 3509 1629 3469 M12056 GO_PEPTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 325/740 Gene Ontology BP GO:0006518 0.00712540796306169 0.00962562385001322 915 2647.63636363636 3247 0.000649871916221619 685 1.10860976337823 -0.955093391000181 -1 2.64831760025328 915 4266 3506 4514 3340 685 948 2142 3247 4157 1404 3470 M11368 GO_POSTREPLICATION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTREPLICATION_REPAIR.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. 26/72 Gene Ontology BP GO:0006301 0.0106360544646788 0.01404927478791 1595 2894.54545454545 3248 0.000971620542512795 1312 0.883024949770493 -0.883024949770493 -1 1.93763884794211 1591 4126 3248 4405 3928 1508 1591 1312 4220 3989 1922 3471 M15618 GO_DORSAL_VENTRAL_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 14/35 Gene Ontology BP GO:0009950 0.0164165810524383 0.021297062259422 1845 2918.54545454545 3248 0.00150367074330567 1271 1.01290004161008 1.08694129910067 1 2.00584583447214 1842 3742 2765 3381 3363 2305 1271 3418 4058 3248 2711 3472 M16551 GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 26/71 Gene Ontology BP GO:0006636 7.80144865938659e-05 0.000145178862226581 3495 3178 3248 7.09247756482631e-06 1870 1.67754547480019 1.35647288331849 1 7.62725401523556 3492 3464 1870 3248 2374 4533 3654 2952 3042 2663 3666 3473 M15739 GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 13/55 Gene Ontology BP GO:0010866 8.25229158994159e-05 0.00015252941820103 4075 3145.18181818182 3249 7.50236468462855e-06 1452 1.21861008487144 1.18056538146028 1 5.50965824692355 4072 1984 1452 2747 2385 3262 4617 4441 3901 2487 3249 3474 M15937 GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. 14/21 Gene Ontology BP GO:0043162 0.27979545061016 0.30274767587578 3330 3109.09090909091 3250 0.0293974189791446 1627 1.14624687756578 -1.01851677579764 -1 0.704619983171827 3330 3804 2794 3929 3993 1923 1627 3046 4122 3250 2382 3475 M10938 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 49/136 Gene Ontology BP GO:0042993 2.38717810749548e-05 5.18412907067424e-05 3815 2935.90909090909 3251 2.17018546427642e-06 1387 1.68956703626242 -1.7849840730564 -1 8.57703391054774 3815 3063 2450 2183 2012 3333 3805 3648 1387 3348 3251 3476 M15237 GO_MITOCHONDRIAL_GENOME_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_GENOME_MAINTENANCE.html The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. 19/31 Gene Ontology BP GO:0000002 0.000917612996612763 0.0013873256734852 4200 3477.63636363636 3251 8.34541776103169e-05 2434 0.998193892271814 -0.559226929601774 -1 3.37930899698526 4199 3251 2972 3657 2909 4386 3149 2434 2763 3905 4629 3477 M10872 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME.html A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. 11/33 Gene Ontology BP GO:0001977 2.9286978627723e-05 6.13902671641165e-05 4010 3149.81818181818 3252 2.66248804645015e-06 1990 1.56536294077562 1.8369349544004 1 7.81036188074123 4010 2929 1990 3252 2089 3965 3858 3269 3034 2226 4026 3478 M13825 GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 20/39 Gene Ontology BP GO:0009262 0.0733315539680611 0.0889205815295152 2505 3406.36363636364 3252 0.0068996727272709 2501 0.639413229109423 -0.642077409218666 -1 0.796087068824589 2501 3252 3230 4212 3576 2872 2963 3449 3991 4440 2984 3479 M14627 GO_CERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. 40/80 Gene Ontology BP GO:0006672 1.70146932637052e-05 3.88967113852206e-05 4300 3218.36363636364 3252 1.54680225963111e-06 789 1.13412226538442 -0.979083598570329 -1 5.92495455457124 4298 789 2476 2696 1911 4568 3657 4359 3252 2876 4520 3480 M11781 GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 6/28 Gene Ontology BP GO:0030656 0.00177478634523795 0.00256708193175695 3325 3228.72727272727 3253 0.000177620538049487 948 2.83367012658679 -2.83367012658679 -1 8.69602961528056 3323 4261 3804 3898 4576 2969 3253 948 2749 3119 2616 3481 M10706 GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization of an epithelial cell. 15/37 Gene Ontology BP GO:0090162 1.74703092529781e-05 3.97620813046948e-05 4535 3263.45454545455 3254 1.58822254428307e-06 1923 0.926059402448816 0.79081384708447 1 4.82749541475336 4535 2159 2738 3254 1923 3147 4564 2471 3389 3331 4387 3482 M13358 GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. 936/2297 Gene Ontology BP GO:0006796 1.08408558451507e-07 1.2939355704122e-06 4140 2950 3254 1.08408563740094e-08 146 1.32187412883502 -1.1850263938874 -1 9.22024304770602 4139 3059 4059 4071 146 1179 4294 3254 2836 3309 2104 3483 M14500 GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. 35/83 Gene Ontology BP GO:1901292 0.000194344127731705 0.000332721159682267 3255 3293.81818181818 3254 1.76692088975827e-05 1823 1.22256066745556 1.52761739433457 1 5.03695315186774 3254 2688 2466 4342 2578 4587 4265 1823 3235 3311 3683 3484 M11555 GO_REGULATION_OF_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of tolerance induction. 20/59 Gene Ontology BP GO:0002643 0.0839184282471183 0.0949861682962873 3265 3114.54545454545 3255 0.00793650793650794 2038 2.28482816520192 -2.51404474278763 -1 2.7671109826088 3263 3600 2038 2974 4017 2685 3255 3266 3002 2640 3520 3485 M16222 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 22/35 Gene Ontology BP GO:0090503 0.0150257414318679 0.0195528356132743 4190 2977.54545454545 3255 0.00137539614589427 1341 0.798898473774376 -0.82183161990898 -1 1.6171786499033 1708 4188 3255 4491 3350 1341 1626 2473 4186 3958 2177 3486 M14052 GO_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G2_M_PHASE_TRANSITION.html The cell cycle process by which a cell in G2 phase commits to M phase. 80/243 Gene Ontology BP GO:0044839 0.0839184282471183 0.0949861682962873 1925 3224.36363636364 3256 0.00793650793650794 1519 1.25862333497987 1.36169034286573 1 1.52429350286778 1925 4416 3256 4138 4234 2822 1519 3036 3510 4060 2552 3487 M12901 GO_G1_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage. 45/99 Gene Ontology BP GO:0044783 9.48467286910113e-05 0.000173015056958168 3845 3258.36363636364 3259 8.62280163492444e-06 1287 2.07790120316608 -1.70391055932738 -1 9.26002209244019 3842 4550 2529 4497 2421 2680 3259 4273 1287 3099 3405 3488 M15520 GO_RESPONSE_TO_ACIDIC_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACIDIC_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. 7/28 Gene Ontology BP GO:0010447 0.00815417364676642 0.0109389853342781 3260 2807.54545454545 3259 0.000818424983265063 1216 1.31590727889545 -1.56943969153672 -1 3.05693236793807 3259 1216 4417 1322 3285 4228 4567 1309 1796 1512 3972 3489 M11995 GO_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 60/201 Gene Ontology BP GO:0001816 0.00700507552653823 0.00947224968877576 2720 3302.72727272727 3261 0.000638861864047612 1903 1.37075276573668 -1.15641913978767 -1 3.28586923883438 2720 4054 1903 3915 3261 3250 2844 4154 3573 3537 3119 3490 M13496 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune system process. 722/2113 Gene Ontology BP GO:0002682 6.68344703377542e-07 3.41753794909904e-06 3265 2677.72727272727 3262 6.68344904385716e-08 328 1.65652118148757 -1.46112524057899 -1 10.7267319839922 3262 1596 4086 1682 827 3584 4155 3604 2118 328 4213 3491 M10534 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS.html Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 9/17 Gene Ontology BP GO:0010561 0.00910241686893191 0.0121548810820969 1255 2510.09090909091 3263 0.000913991753320016 691 1.24717024239523 -1.24717024239523 -1 2.82962505692746 1255 3263 3600 3460 3571 815 691 2081 4201 3479 1195 3492 M10674 GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 28/65 Gene Ontology BP GO:0009247 0.000143261063616776 0.000250814901347169 3100 3130.72727272727 3263 1.30245812215091e-05 1314 0.98414552325534 -0.75795018064062 -1 4.19776144755367 3098 2854 2872 4067 2516 3866 1314 3314 3505 3263 3769 3493 M13738 GO_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NIK_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). 58/119 Gene Ontology BP GO:0038061 0.0839184282471183 0.0949861682962873 2565 3267.18181818182 3263 0.00793650793650794 1866 1.53193036650099 -1.43091293007999 -1 1.85529053787206 2561 4477 3263 3617 4406 1866 2350 3991 3184 3689 2535 3494 M11188 GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 8/17 Gene Ontology BP GO:0009129 0.0947208198702436 0.106900526654726 1925 3111.09090909091 3265 0.00990184039482622 1612 0.571605558015385 -0.571605558015385 -1 0.657508964509063 1922 3265 3704 4393 3629 1732 1612 3054 4289 4249 2373 3495 M11304 GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 33/82 Gene Ontology BP GO:0033143 4.39953503409401e-06 1.26732448024964e-05 3735 3228.63636363636 3265 3.99958530205352e-07 1515 1.07507290098314 -1.23809615208987 -1 6.23671576492712 3735 3089 3077 2880 1515 2266 4106 4527 3499 3556 3265 3496 M11750 GO_RNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLATION.html Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. 30/57 Gene Ontology BP GO:0001510 0.282648636710077 0.305692434252245 2290 3405.09090909091 3265 0.0297476110582928 1848 0.650388808897222 -0.670213924761512 -1 0.396566848416125 2288 4236 3265 4527 4630 1848 2801 2716 4406 4286 2453 3497 M16090 GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. 9/32 Gene Ontology BP GO:1902187 0.00646992675599303 0.00879129936437683 3240 3470.45454545455 3265 0.000648884128517736 2382 0.922076636981213 0.922076636981213 1 2.24572562706818 3240 2992 4506 3464 3265 3081 2382 3284 4215 4591 3155 3498 M14732 GO_HISTONE_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving an mRNA encoding a histone. 14/31 Gene Ontology BP GO:0008334 0.0140950589674982 0.0183881311565311 1730 2977.45454545455 3266 0.00128965292891671 1728 0.677587055708721 -0.677587055708721 -1 1.39302172269432 1728 3604 3266 4009 3337 2005 2180 1841 3818 4497 2467 3499 M10549 GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION.html Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. 7/14 Gene Ontology BP GO:1901970 3.03048242016347e-06 9.54581402769266e-06 2420 2843.36363636364 3268 3.03048655289206e-07 115 1.8818988242565 -1.8818988242565 -1 11.1916521871982 2416 3923 3601 3570 3855 2008 2730 115 4011 3268 1780 3500 M10329 GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. 44/108 Gene Ontology BP GO:0009132 0.0168975699303109 0.021902684865001 2810 3235.27272727273 3270 0.00154806984436821 2603 1.0399700216377 -0.926960844802897 -1 2.04445009501346 2808 3364 3133 3881 3367 2603 3270 2937 3359 3967 2899 3501 M10647 GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. 7/14 Gene Ontology BP GO:0045842 4.15214101912982e-06 1.21476942355512e-05 2420 2847.81818181818 3270 4.152148777274e-07 141 1.8818988242565 -1.8818988242565 -1 10.9582839481925 2417 3924 3614 3571 3856 2009 2731 141 4012 3270 1781 3502 M10043 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY.html A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. 18/46 Gene Ontology BP GO:0045005 0.567818371140704 0.596466221087396 2585 3496.63636363636 3271 0.0734288905945204 2585 0.517174830436356 -0.517174830436356 -1 0.13748660873552 2585 3772 3106 4116 3956 3112 3008 2959 4398 4180 3271 3503 M11426 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. 40/88 Gene Ontology BP GO:1903363 0.0839184282471183 0.0949861682962873 2395 3155 3271 0.00793650793650794 1903 0.904179502095291 -0.964235179266796 -1 1.09503320499913 2394 4232 3271 4312 3791 1903 2572 2570 3581 4012 2067 3504 M10610 GO_NEGATIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. 35/78 Gene Ontology BP GO:0051782 0.0839184282471183 0.0949861682962873 2295 3229.18181818182 3272 0.00793650793650794 2185 1.51242126377874 1.81194555295129 1 1.83166342838747 2294 3596 2185 3272 4189 3625 3759 3211 2522 3639 3229 3505 M12996 GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS.html The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. 9/15 Gene Ontology BP GO:0019184 0.0765897756730953 0.0916038970762961 3275 3146.36363636364 3272 0.00793650793650794 1867 1.04234165050707 -1.13662400333827 -1 1.28180209974817 3272 1867 3992 3197 3672 3705 3709 2247 3326 2683 2940 3506 M13702 GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. 20/36 Gene Ontology BP GO:0000959 0.00929306836998097 0.0123987690924775 1230 2784.54545454545 3272 0.00084841428638733 1229 0.708263259496454 -0.708263259496454 -1 1.59969367801322 1229 3469 3272 4486 3647 1495 1269 1283 3955 4435 2090 3507 M16244 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI.html The directed movement of a protein to a specific location in the Golgi apparatus. 9/19 Gene Ontology BP GO:0072600 0.04377073657304 0.0542953593130175 2055 3348.09090909091 3272 0.00446575666026882 1520 0.549975587225531 -0.549975587225531 -1 0.824313875863604 2052 3264 4534 3928 4602 1520 2885 3272 4484 4598 1690 3508 M11283 GO_RESPONSE_TO_FUNGICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. 7/20 Gene Ontology BP GO:0060992 0.0118386655340539 0.0155537419565965 3220 3153.54545454545 3274 0.00119022118137554 2115 2.13231238342611 2.13231238342611 1 4.56737695054662 3219 3818 3723 3709 3328 3952 2161 2115 2918 3274 2472 3509 M16491 GO_PROTEIN_TARGETING_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_LYSOSOME.html The process of directing proteins towards the lysosome using signals contained within the protein. 16/25 Gene Ontology BP GO:0006622 0.154189134885029 0.171596393401531 3100 3369.81818181818 3274 0.0151082985706112 2107 0.985515383942352 -0.985515383942352 -1 0.893678398348065 3096 4440 3066 4177 4487 2107 3274 2132 4277 3843 2169 3510 M11435 GO_OXALOACETATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALOACETATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. 7/12 Gene Ontology BP GO:0006107 0.00639507072150456 0.00869722125364548 1620 2531 3275 0.000641354922566547 914 0.922712056773238 -0.922712056773238 -1 2.25238058022555 1617 3535 3745 3563 3384 1312 914 1600 3793 3275 1103 3511 M14294 GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. 55/211 Gene Ontology BP GO:0050830 0.00273590820985871 0.00387754023759889 3605 3250.27272727273 3276 0.000249028773279893 1792 1.66713600084522 -1.69175283535915 -1 4.76240255747003 3601 3336 1792 3491 3107 3230 4275 3210 3276 3013 3422 3512 M16248 GO_NEGATIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_KILLING.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. 21/80 Gene Ontology BP GO:0031342 0.0839184282471183 0.0949861682962873 2515 2875 3276 0.00793650793650794 1616 2.35174868055761 -2.41514327785301 -1 2.84815716733523 3276 3401 1616 2515 4162 2511 3548 3792 1754 1691 3359 3513 M10871 GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. 85/179 Gene Ontology BP GO:0035567 0.00406615197386442 0.00564905553999177 3460 3292 3277 0.000370335158793794 2505 1.40349213304852 1.2636209875825 1 3.73756593083999 2505 3458 3096 3277 3176 4032 2858 3731 2942 3456 3681 3514 M11671 GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. 5/28 Gene Ontology BP GO:0044788 0.00456255535688727 0.00631790770117136 3705 2795.54545454545 3277 0.000457195012568838 372 2.22477650816358 -1.782269287272 -1 5.79660708308013 3702 2292 3787 1492 3202 3729 3277 3926 372 1089 3883 3515 M11864 GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE.html The movement of organelles or other particles from one location in the cell to another along microtubules. 67/133 Gene Ontology BP GO:0010970 0.0299195459840647 0.0378622109577575 2745 3168.36363636364 3277 0.00275766959151808 1348 1.03982221770503 1.05523742928529 1 1.75135208354685 2741 2906 3277 3887 3436 2903 1348 3898 3598 3942 2916 3516 M12616 GO_MICROTUBULE_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_DEPOLYMERIZATION.html The removal of tubulin heterodimers from one or both ends of a microtubule. 7/16 Gene Ontology BP GO:0007019 0.320995102546557 0.345715671798577 1775 3214.90909090909 3279 0.0379729342822828 1775 1.4411825155897 -0.716517576804582 -1 0.787520127148095 1775 3507 3938 3512 4346 2919 2765 2488 3897 3279 2938 3517 M14289 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleoside across a membrane. 7/13 Gene Ontology BP GO:1901642 0.0028344213700064 0.00401103883600723 3675 3075.09090909091 3279 0.000283804314830008 852 0.728848199074853 -0.57655520715211 -1 2.06936131223882 3671 852 4219 2203 3134 3279 2860 3560 3192 3289 3567 3518 M12745 GO_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. 19/43 Gene Ontology BP GO:0031440 0.0631603907544108 0.0769694735623961 2065 2893.27272727273 3280 0.00591364390681339 1246 0.86836147906864 -0.86836147906864 -1 1.14561584815662 2063 3494 3280 3660 4100 1246 1312 2335 4196 4355 1785 3519 M13351 GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY.html A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. 7/24 Gene Ontology BP GO:0007597 0.0368223257997532 0.0460576666724823 2365 3170.18181818182 3281 0.00374470937023062 1677 1.45455665270868 1.45455665270868 1 2.3032535317989 2362 3897 4058 3934 4051 2532 1999 1677 4258 3281 2823 3520 M16462 GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT.html The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. 81/166 Gene Ontology BP GO:0030705 0.00861855206720912 0.0115419490187632 2065 3016.18181818182 3281 0.000786591072169239 1291 1.02719270232558 1.03754547194359 1 2.35787582197473 2061 2804 3321 3710 3281 2361 1291 4178 3600 3980 2591 3521 M13323 GO_HEART_VALVE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_FORMATION.html The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. 9/24 Gene Ontology BP GO:0003188 0.000126152351308517 0.000223986756070916 3285 3045 3282 1.2615951336783e-05 1203 1.65229471064631 1.7723431922999 1 7.14384331375999 3282 1943 4053 2908 2507 3971 3533 3471 3107 1203 3517 3522 M13906 GO_TRACHEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_DEVELOPMENT.html The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. 13/31 Gene Ontology BP GO:0060438 0.000809560779362752 0.00123545306939178 3990 3242.72727272727 3282 7.36235306236501e-05 1932 1.37990894158524 0.929404955529198 1 4.75388560075058 3986 3689 2215 2882 2879 4410 3412 1932 3282 2480 4503 3523 M15915 GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. 28/101 Gene Ontology BP GO:0002715 0.0152013510700914 0.0197758119973198 4495 3200.18181818182 3282 0.00139158321579313 1534 1.79814979983362 2.41790224117119 1 3.62943583999457 4493 3282 1534 2913 3352 3974 4076 2178 2916 1951 4533 3524 M12124 GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. 18/40 Gene Ontology BP GO:0060674 0.000580839156442958 0.000912943873853979 3285 3414 3283 5.28175059113533e-05 2774 0.892845254016585 0.908105407266709 1 3.21487585384502 3283 2789 2774 2780 2801 4593 4577 3032 3746 3545 3634 3525 M13916 GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. 7/24 Gene Ontology BP GO:0055098 0.449393153661075 0.477795377249456 2835 3314.90909090909 3283 0.0579278596284851 2018 1.60578086760453 1.60578086760453 1 0.610155818460007 2833 2709 4156 3398 3912 3210 2018 3800 4120 3283 3025 3526 M16917 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. 13/64 Gene Ontology BP GO:0045620 0.00922118989312543 0.0123064054825471 3285 3220.18181818182 3284 0.000841824398306431 2307 1.15078365138924 -1.29319575997802 -1 2.60360462288109 3284 3437 2553 4151 3289 2307 2848 3198 3583 3764 3008 3527 M14315 GO_NON_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_RECOMBINATIONAL_REPAIR.html A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. 41/88 Gene Ontology BP GO:0000726 0.0111621284497578 0.0146898419479097 785 2711.27272727273 3287 0.00101992429566349 783 0.83809696659847 -0.83809696659847 -1 1.81982814337307 783 4087 3287 4128 3314 1150 1439 1664 3990 4019 1963 3528 M13248 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 20/47 Gene Ontology BP GO:0071157 0.0100662668349278 0.0133345725861826 4130 3231.72727272727 3288 0.000919329365832164 1797 0.748461613817266 -0.830559639396987 -1 1.66246804786084 3018 4127 3250 4523 3302 2022 1797 3288 4129 3919 2174 3529 M13365 GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. 20/65 Gene Ontology BP GO:0046637 0.00275809074247238 0.00390778618165983 3740 3359.81818181818 3288 0.000251050416378163 2139 1.32192040250797 -1.38595499262128 -1 3.7709621886457 3740 3249 2194 3877 3108 3288 4508 4389 3331 2139 3135 3530 M14184 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR.html Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. 38/91 Gene Ontology BP GO:0000731 0.137153948570865 0.153336331137618 1265 2970.63636363636 3288 0.0133212930420295 1262 0.791451287239835 -0.791451287239835 -1 0.763510591385387 1262 4031 3288 3787 4206 1671 1600 2083 4367 4066 2316 3531 M13030 GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 3/21 Gene Ontology BP GO:0042423 0.139471126128738 0.155814350003785 3045 3440.72727272727 3289 0.0149085612627978 2459 0.859997863022034 -0.859997863022034 -1 0.822544347630566 3043 2680 3997 2825 3696 3289 3150 3979 4357 4373 2459 3532 M14333 GO_HISTONE_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_UBIQUITINATION.html The modification of histones by addition of ubiquitin groups. 24/40 Gene Ontology BP GO:0016574 0.0593094247808427 0.0725240082321444 2625 3252.18181818182 3289 0.00554285582333815 1792 0.630885652104565 -0.510044552612783 -1 0.851626488805618 2624 3523 3257 4113 3551 1792 2159 3289 4473 4464 2529 3533 M16878 GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. 3/21 Gene Ontology BP GO:0009713 0.139471126128738 0.155814350003785 3045 3522.72727272727 3290 0.0149085612627978 2460 0.859997863022034 -0.859997863022034 -1 0.822544347630566 3044 2681 4628 2826 3697 3290 3151 3978 4358 4637 2460 3534 M14711 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization. 7/22 Gene Ontology BP GO:0031116 0.00192668959794364 0.00277814279604109 3125 3325.45454545455 3291 0.000192836209891466 2598 1.09024807534722 1.09024807534722 1 3.3014578650581 3121 2823 4278 3864 3067 3418 3740 2598 3035 3291 3345 3535 M13744 GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 13/57 Gene Ontology BP GO:2000514 0.00164069285705534 0.00238965245038859 4220 3161.36363636364 3292 0.000149265246795633 1250 1.50723549771844 -1.52515598888733 -1 4.68097474911527 4218 2515 1579 3461 3022 3807 4371 4062 3292 1250 3198 3536 M13747 GO_MRNA_CLEAVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE.html Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. 13/22 Gene Ontology BP GO:0006379 0.250893453898102 0.272809907833463 2270 3193.18181818182 3292 0.0259194491457462 1746 0.568582587762199 -0.568582587762199 -1 0.379976311436153 2267 3886 3292 4291 3870 2194 1746 2349 4153 4438 2639 3537 M12894 GO_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXIT_FROM_MITOSIS.html The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. 10/16 Gene Ontology BP GO:0010458 0.0393250130903866 0.0489769409277535 3580 2944.36363636364 3293 0.00364055072433201 1169 1.47213831035859 -0.594076155607364 -1 2.28454890119383 3578 3917 2528 2940 3487 1731 2168 3293 1169 3580 3997 3538 M13999 GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION.html The modification of peptidyl-glutamic acid. 12/35 Gene Ontology BP GO:0018200 0.0839184282471183 0.0949861682962873 3295 3175 3293 0.00793650793650794 1689 1.29165982241759 -1.66201681922839 -1 1.56430337501773 3294 3013 2509 3679 3812 3945 4497 2141 1689 3053 3293 3539 M10063 GO_CARDIAC_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_ADAPTATION.html The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. 9/17 Gene Ontology BP GO:0014887 0.0131418886858728 0.0171881096249317 2170 3015.63636363636 3294 0.00132202609420422 2007 1.94029809871083 1.94029809871083 1 4.05634565903419 2169 3294 3529 3413 3341 2756 2626 2007 3828 3473 2736 3540 M12117 GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. 17/35 Gene Ontology BP GO:0060765 4.61096375797685e-05 9.12562008878369e-05 4360 3394.81818181818 3294 4.19187309241966e-06 2223 1.22413360781926 -1.23081516807397 -1 5.85814283508328 4359 3116 2896 2339 2223 3294 4207 3890 3215 3463 4341 3541 M13805 GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. 9/17 Gene Ontology BP GO:0003299 0.0131418886858728 0.0171881096249317 2170 3074.36363636364 3295 0.00132202609420422 2015 1.94029809871083 1.94029809871083 1 4.05634565903419 2170 3295 4134 3414 3342 2757 2627 2015 3829 3498 2737 3542 M14986 GO_HISTONE_H3_K4_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_TRIMETHYLATION.html The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. 7/18 Gene Ontology BP GO:0080182 0.0314768126221381 0.0397570296530433 2670 3056.90909090909 3295 0.00319317642171236 1461 1.00861198548302 -1.00861198548302 -1 1.67344557527217 2667 3780 4331 4001 3459 2186 1461 2026 4105 3295 2315 3543 M11125 GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. 35/118 Gene Ontology BP GO:0045824 0.0839184282471183 0.0949861682962873 4370 3353.18181818182 3296 0.00793650793650794 2117 1.51211327570867 -0.936920058052645 -1 1.83129042979522 4366 3112 2117 2823 3610 3502 4368 3296 2922 2497 4272 3544 M11399 GO_MULTICELLULAR_ORGANISMAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MOVEMENT.html Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. 30/75 Gene Ontology BP GO:0050879 0.0839184282471183 0.0949861682962873 2840 3230.81818181818 3296 0.00793650793650794 2137 2.50227772450882 -1.45914256153381 -1 3.03046007755519 2839 4234 2137 4245 3978 3296 2222 3034 2270 3722 3562 3545 M13137 GO_AMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 290/656 Gene Ontology BP GO:0043604 0.0338894023022643 0.042607228510537 1090 2804.90909090909 3296 0.00312936248352856 1062 1.05176824130258 -0.883934568090346 -1 1.7075839470592 1087 4268 3509 4585 3455 1062 1330 2171 3296 4163 1928 3546 M15091 GO_PROTEIN_LOCALIZATION_TO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_SYNAPSE.html Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 7/20 Gene Ontology BP GO:0035418 0.000282175449469373 0.000466740510112682 4505 3259.54545454545 3296 2.82211286216891e-05 1721 0.785387477876001 -0.735045434022753 -1 3.09903604818469 4504 1721 4349 2334 2678 3855 1981 3060 3768 3296 4309 3547 M16171 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 9/20 Gene Ontology BP GO:0090005 0.00969091309661146 0.0128851401797156 1770 2833 3296 0.000973343552285477 840 0.876719020041814 -0.876719020041814 -1 1.96281549111107 1766 2285 4522 3296 3563 840 1629 4408 4117 3514 1223 3548 M16881 GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. 9/17 Gene Ontology BP GO:0014898 0.0131418886858728 0.0171881096249317 2175 3118.90909090909 3296 0.00132202609420422 1981 1.94029809871083 1.94029809871083 1 4.05634565903419 2171 3296 4630 3415 3343 2758 2628 1981 3830 3518 2738 3549 M15233 GO_MUSCULOSKELETAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCULOSKELETAL_MOVEMENT.html The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. 30/75 Gene Ontology BP GO:0050881 0.0839184282471183 0.0949861682962873 2840 3229 3297 0.00793650793650794 2138 2.50227772450882 -1.45914256153381 -1 3.03046007755519 2840 4235 2138 4246 3979 3297 2223 3004 2271 3723 3563 3550 M13938 GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. 11/18 Gene Ontology BP GO:0007004 0.617257765474187 0.645624646338511 2560 3501.81818181818 3298 0.0836056584069776 2196 0.186444918802934 -0.212828346885129 -1 0.0419672327715594 2559 4308 3298 4179 4384 2359 2196 3175 4518 4446 3098 3551 M14592 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 25/80 Gene Ontology BP GO:0051926 5.13178206764934e-05 0.000100492889667212 4425 2880.54545454545 3298 4.66536525177727e-06 807 1.13757148871724 -0.951323001840404 -1 5.38746861529799 4039 807 1671 1180 2252 4425 3299 4422 3298 2129 4164 3552 M15715 GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. 7/14 Gene Ontology BP GO:1902101 8.30968940381377e-06 2.12338403422715e-05 2420 2931.63636363636 3299 8.3097204768994e-07 194 1.8818988242565 -1.8818988242565 -1 10.4175940599627 2418 3925 4446 3572 3857 2010 2732 194 4013 3299 1782 3553 M11997 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. 265/608 Gene Ontology BP GO:0032388 1.40542976450763e-06 5.61567159777016e-06 3000 3193.36363636364 3300 1.27766423849231e-07 1070 1.40685519972488 1.60461462347366 1 8.75056734812477 2996 3900 2789 3978 1070 4632 3300 2794 2456 3665 3547 3554 M11491 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. 5/21 Gene Ontology BP GO:0002674 0.184136672472577 0.203461820630694 3020 3273.45454545455 3301 0.0201451621012272 1346 1.06778517755282 1.06778517755282 1 0.874709940353832 3019 2939 3758 3566 4577 3301 1346 2746 4253 2977 3526 3555 M12214 GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. 10/23 Gene Ontology BP GO:0034104 0.303706417133128 0.327856055510141 3305 3182.72727272727 3301 0.0323720615024975 1436 0.920508165694724 -0.99772140124993 -1 0.528121550609689 3301 1436 2176 2755 4091 3744 4500 2429 3925 3572 3081 3556 M16738 GO_V_D_J_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_V_D_J_RECOMBINATION.html The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). 7/17 Gene Ontology BP GO:0033151 0.000924439125242138 0.00139628199690932 4505 3424.36363636364 3303 9.2482391501055e-05 1477 1.60853736003445 -0.654162550255648 -1 5.44025577189824 4505 1822 4613 2935 2930 4340 4210 3125 1477 3303 4408 3557 M12577 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. 14/40 Gene Ontology BP GO:0000027 0.23475032347652 0.255855810305512 2370 3105.54545454545 3304 0.0240295905941235 1411 0.774938011584202 -0.774938011584202 -1 0.543461631506112 2366 3741 3304 3610 4160 1768 1411 3129 3987 4347 2338 3558 M14705 GO_ACTIVATION_OF_MAPKKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKKK_ACTIVITY.html Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). 7/13 Gene Ontology BP GO:0000185 0.00298441530061067 0.00420663030987716 3220 3226.09090909091 3304 0.000298843092334706 1349 1.5704859090617 0.938893800299153 1 4.42049004691523 3220 3449 4275 3304 3142 3820 2390 4054 1349 2396 4088 3559 M11027 GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION.html The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 9/25 Gene Ontology BP GO:0021694 0.0389143265733898 0.0485044881289259 2620 3054.27272727273 3305 0.00396130561672351 1643 1.07016405521462 -1.07016405521462 -1 1.66607849486897 2616 3324 3672 3732 3901 2018 3305 2781 3935 2670 1643 3560 M13281 GO_4_HYDROXYPROLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_HYDROXYPROLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. 12/15 Gene Ontology BP GO:0019471 0.0103942643317104 0.0137533682793193 4365 3380.27272727273 3305 0.000949427369676931 2352 1.15128241895265 -0.944948855253188 -1 2.53889032382931 4363 2439 2730 2711 3305 3189 3912 4351 3778 2352 4053 3561 M13298 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING.html Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. 14/30 Gene Ontology BP GO:0006297 0.822739746612955 0.844754675701891 2080 3446.18181818182 3305 0.145539595642809 2079 0.682644927281669 -0.682644927281669 -1 0.0592493038545236 2079 3634 3233 3773 4245 2820 2915 3305 4378 4399 3127 3562 M14220 GO_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_METHYLATION.html The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. 16/38 Gene Ontology BP GO:0051568 0.0246195934481671 0.0313518300548107 2405 3090.63636363636 3305 0.00226359088830629 1406 0.721753264955348 -0.721753264955348 -1 1.28569574469962 2402 4296 3305 4489 4411 1406 2238 2112 4035 3838 1465 3563 M12806 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. 15/43 Gene Ontology BP GO:0051769 0.0271696054355362 0.0345233930041583 3210 3373 3306 0.00250100579203178 2435 1.00690838759587 -0.504674660524815 -1 1.74373829429099 3206 4300 2904 3505 3429 3306 2435 3161 4092 3809 2956 3564 M13019 GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION.html The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. 9/25 Gene Ontology BP GO:0021702 0.0389143265733898 0.0485044881289259 2620 3081.54545454545 3306 0.00396130561672351 1644 1.07016405521462 -1.07016405521462 -1 1.66607849486897 2617 3325 3994 3733 3902 2019 3306 2737 3936 2684 1644 3565 M13819 GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that activates or increases the frequency, rate or extent of chromatin modification. 48/111 Gene Ontology BP GO:1903310 2.39877839289179e-05 5.20237631882243e-05 3380 3081.90909090909 3308 2.18073140769343e-06 1633 2.0194379534774 -1.65899346301473 -1 10.2479630821925 3377 3591 2377 2737 2013 4304 3790 3160 1633 3308 3611 3566 M15982 GO_CHROMATIN_SILENCING_AT_RDNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING_AT_RDNA.html Repression of transcription of ribosomal DNA by altering the structure of chromatin. 25/40 Gene Ontology BP GO:0000183 0.0106395013638893 0.0140498307259778 2705 3264.72727272727 3308 0.000971936958437594 2243 1.47789659795545 -0.999004826882844 -1 3.24294833973744 2703 3399 2243 3177 3308 2924 3441 4416 3126 3535 3640 3567 M16197 GO_HISTONE_H3_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_ACETYLATION.html The modification of histone H3 by the addition of an acetyl group. 30/51 Gene Ontology BP GO:0043966 0.037758745611498 0.0471654172381451 1660 2906.72727272727 3308 0.00349298307051457 1146 0.808023731111149 -0.808023731111149 -1 1.26960435017172 1656 4623 3308 4565 3611 1146 1574 1737 4128 4025 1601 3568 M13428 GO_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRAND_BREAK_REPAIR.html The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. 93/195 Gene Ontology BP GO:0006302 0.0839184282471183 0.0949861682962873 1340 3108.09090909091 3309 0.00793650793650794 1340 1.02942661698187 -0.803699786907674 -1 1.24671764370372 1340 4151 3309 4377 3748 1899 2374 2541 3623 4095 2732 3569 M13933 GO_NADH_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_METABOLIC_PROCESS.html The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 21/54 Gene Ontology BP GO:0006734 0.0839184282471183 0.0949861682962873 3265 3217 3309 0.00793650793650794 2209 1.28337816922921 -1.28337816922921 -1 1.55427361970909 3264 3685 2808 3583 3735 2443 3948 2689 3309 3714 2209 3570 M13829 GO_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENETIC_IMPRINTING.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 9/23 Gene Ontology BP GO:0071514 0.00132404754717334 0.00195408542960134 2635 2695 3311 0.000132483710520649 802 2.87605451965866 -2.87605451965866 -1 9.22981916683068 2635 3476 4140 3804 3910 980 1000 2088 3311 3499 802 3571 M14382 GO_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE.html Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. 95/350 Gene Ontology BP GO:0051321 0.0839184282471183 0.0949861682962873 1320 3385.90909090909 3311 0.00793650793650794 1320 1.69128904015874 2.07215120405222 1 2.04828684751459 1320 4534 2747 4193 4599 2987 2810 3311 3500 4103 3141 3572 M15528 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. 15/55 Gene Ontology BP GO:0046638 0.00656993530062458 0.00891154238995031 4135 3374.27272727273 3312 0.000599057976907033 2124 1.34058247093296 -1.46596885621346 -1 3.25563161831613 4132 2957 2181 3221 3249 4610 3513 3397 3312 2124 4421 3573 M11210 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 12/21 Gene Ontology BP GO:0009148 0.514011397665828 0.542522145797326 3095 3457.45454545455 3313 0.0634920634920635 2612 0.686185989175764 -0.711939850730658 -1 0.215881818207762 2612 3379 3005 4211 4122 2914 3092 3094 4038 4252 3313 3574 M14822 GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY.html The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 13/26 Gene Ontology BP GO:0035058 0.0110622716587869 0.0145666838660656 3215 3171.54545454545 3313 0.00101075371740324 1909 0.876016207501942 0.876016207501942 1 1.90595978930652 3214 1909 3222 2718 3313 3942 2131 3586 3333 3755 3764 3575 M16056 GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. 53/124 Gene Ontology BP GO:0048524 0.03438621492261 0.0431850678619632 3315 3002.45454545455 3313 0.00317597616757753 1361 1.31054971955513 -1.27945711428925 -1 2.11864286822509 3313 4119 2766 4215 3713 1361 2081 3682 3320 2886 1571 3576 M11207 GO_PROTEASOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ASSEMBLY.html The aggregation, arrangement and bonding together of a mature, active proteasome complex. 10/17 Gene Ontology BP GO:0043248 0.289343773369247 0.312714883555264 2685 3366.54545454545 3315 0.0305743512468521 2369 0.807585301641838 -0.807585301641838 -1 0.482979393544831 2685 3980 3168 3888 3953 2369 3315 2647 4383 4250 2394 3577 M10374 GO_REGULATION_OF_ICOSANOID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ICOSANOID_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. 12/42 Gene Ontology BP GO:0032303 0.00227632936644436 0.00325099884601697 3320 3190.54545454545 3317 0.000207153462811855 1494 0.901408783938297 -0.597542118573987 -1 2.65672775793495 3317 3347 2520 3075 3079 4016 3087 1494 3890 3692 3579 3578 M11743 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that modulates the frequency, rate or extent of extracellular matrix organization. 16/44 Gene Ontology BP GO:1903053 3.35970599175466e-05 6.89006842743678e-05 4000 3082.09090909091 3317 3.0543248183955e-06 1344 1.25036428222582 1.47929677497703 1 6.16443520851569 3999 3317 2426 1344 2139 3508 4360 2894 3367 2849 3700 3579 M10089 GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS.html A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. 13/26 Gene Ontology BP GO:0006278 0.491421045138995 0.519505444576584 3125 3395 3318 0.0596158344876058 2010 0.205583436841943 -0.242066298849544 -1 0.0692628540873172 2383 4201 3318 4125 4216 2178 2010 3122 4485 4185 3122 3580 M13926 GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. 73/188 Gene Ontology BP GO:0050852 0.0117172320044944 0.0153985587876783 2085 2966 3319 0.00107091886191769 1014 1.25017343440564 -1.23667584766391 -1 2.6842989719253 2083 4053 3319 3782 4638 1014 1725 3692 3240 3830 1250 3581 M14750 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. 17/30 Gene Ontology BP GO:1904376 0.597318307603006 0.625332334205357 3740 3397.90909090909 3319 0.0793650793650794 2275 0.876719020041814 -0.876719020041814 -1 0.211752780095058 3738 2275 2817 3122 3986 3319 4088 2923 4102 3868 3139 3582 M16418 GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 13/30 Gene Ontology BP GO:0051984 0.0839184282471183 0.0949861682962873 3815 3259.72727272727 3319 0.00793650793650794 2395 1.72303005623406 -1.8818988242565 -1 2.086727798523 3811 3584 2530 3319 3838 2995 3846 2395 3572 3184 2783 3583 M11632 GO_CARTILAGE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_MORPHOGENESIS.html The process in which the anatomical structures of cartilage are generated and organized. 8/20 Gene Ontology BP GO:0060536 0.010618406742146 0.0140339489051477 3435 3138.09090909091 3320 0.00106694883545629 1732 2.22753787480345 1.97559636232849 1 4.88918313374874 3432 3298 3778 2380 3320 3707 2342 4579 1970 1732 3981 3584 M16221 GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA.html The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. 14/60 Gene Ontology BP GO:0007339 0.21163619503166 0.232134857909756 3225 3252.54545454545 3320 0.0213857935461088 1590 0.75635451251946 -0.681362543918878 -1 0.568289059783956 3224 4301 3017 4174 3934 1811 1590 3320 4372 3787 2248 3585 M16531 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. 17/30 Gene Ontology BP GO:1903077 0.597318307603006 0.625332334205357 3740 3396.81818181818 3320 0.0793650793650794 2276 0.876719020041814 -0.876719020041814 -1 0.211752780095058 3739 2276 2818 3123 3987 3320 4089 2900 4103 3870 3140 3586 M12715 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX.html The joining of the small ribosomal subunit, ternary complex, and mRNA. 10/23 Gene Ontology BP GO:0001731 0.0604768334890384 0.0738348508781502 2315 3118.27272727273 3322 0.00565511313334843 1326 0.593097012655392 -0.593097012655392 -1 0.795149970988701 2312 4253 3322 4110 3940 1326 1465 3167 4285 4354 1767 3587 M14428 GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 12/35 Gene Ontology BP GO:0051569 0.00690297675627599 0.00934962691930846 3535 3393 3322 0.000629521088030502 2951 1.13918936727119 1.27878511939577 1 2.73841859562027 3535 3071 2951 3084 3256 3322 4441 3252 3343 3702 3366 3588 M12478 GO_NCRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_TRANSCRIPTION.html The transcription of non (protein) coding RNA from a DNA template. 46/106 Gene Ontology BP GO:0098781 0.0839184282471183 0.0949861682962873 2335 3201.63636363636 3323 0.00793650793650794 1988 1.19622053683039 -1.16503427743523 -1 1.44871864096799 2331 4281 3382 4502 4445 1988 2345 2020 3323 4040 2561 3589 M14179 GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION.html The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. 7/21 Gene Ontology BP GO:0043046 0.000353525332832693 0.000574123162064425 4185 3089.27272727273 3323 3.53581586500692e-05 331 3.12144353544104 3.12144353544104 1 11.9842780296178 4181 2645 4199 2492 2724 3717 3323 3752 331 3287 3331 3590 M16875 GO_TRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. 32/58 Gene Ontology BP GO:0006400 0.0322976140161071 0.0407272737307944 1980 3290.36363636364 3323 0.00298015880027432 1976 0.736389966316857 -0.805823625233523 -1 1.2126514357366 1976 3906 3323 4452 3446 2285 3165 2530 4125 4636 2350 3591 M13024 GO_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 45/116 Gene Ontology BP GO:0048145 0.000970081427288939 0.0014599961318971 4230 3231.27272727273 3324 8.82281313784956e-05 1638 1.92687335894857 -1.62584660355647 -1 6.47267088953548 4230 3826 1638 2303 2918 3949 4281 3324 1793 2759 4523 3592 M14603 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE.html The directed movement of a protein to a specific location in a vacuole. 28/44 Gene Ontology BP GO:0072666 0.0313746067075063 0.039649509783057 1860 2900.36363636364 3324 0.00289374437848286 1256 0.984965323070267 -0.984965323070267 -1 1.63558430235902 1858 4237 3324 4046 4117 1256 1514 1611 4187 4009 1745 3593 M10341 GO_PINOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PINOCYTOSIS.html An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. 9/23 Gene Ontology BP GO:0006907 0.000149304025658526 0.000260510556607493 4155 3148.36363636364 3325 1.49314057868612e-05 2114 1.38638056123263 -1.73067678359929 -1 5.88639775223086 4154 2114 3568 2159 2557 3555 3107 3353 3325 2667 4073 3594 M15432 GO_NEUTROPHIL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a neutrophil. 13/36 Gene Ontology BP GO:0002446 0.232850105696956 0.253922063757934 3290 3446.90909090909 3325 0.0238095238095238 2454 1.67850177463967 1.67850177463967 1 1.1836814770029 3287 2845 3034 3325 4642 4084 2989 2454 3792 3759 3705 3595 M12847 GO_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_VACUOLE.html A process in which a protein is transported to, or maintained at, a location in a vacuole. 35/61 Gene Ontology BP GO:0072665 0.0828291046504743 0.0949861682962873 2460 3224.72727272727 3326 0.00782932271178669 1554 0.984965323070267 -0.984965323070267 -1 1.19287140207837 2460 4286 3326 4503 4147 1554 2650 2455 4167 4054 1870 3596 M13153 GO_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 15/40 Gene Ontology BP GO:0010939 0.0128377051856167 0.0168139535054495 3725 3357.63636363636 3327 0.00117393046117639 2721 1.19557339123062 -1.15082268762976 -1 2.51297683959799 3725 2985 2750 3532 3327 3100 3655 4534 3703 2721 2902 3597 M16400 GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html The directed movement of proteins from the endoplasmic reticulum. 15/29 Gene Ontology BP GO:0032527 0.0330131918846168 0.0415731624410837 2255 3132.54545454545 3327 0.00304720469994516 1288 0.651346786764925 -0.651346786764925 -1 1.06571763861756 2253 4064 3327 4311 3556 1288 2017 3043 4426 4609 1564 3598 M13860 GO_REGULATION_OF_MRNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_POLYADENYLATION.html Any process that modulates the frequency, rate or extent of mRNA polyadenylation. 8/13 Gene Ontology BP GO:1900363 0.0810271793418393 0.0949861682962873 2015 3038.72727272727 3328 0.00841427336074034 1068 0.31845306426149 -0.36505312742536 -1 0.38567086928612 2013 3328 4146 3756 3846 1698 1068 2348 4513 4444 2266 3599 M15957 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. 31/133 Gene Ontology BP GO:0002440 6.81918713665415e-06 1.7979265119526e-05 3740 3319.54545454545 3328 6.19928024882402e-07 1656 0.877728106264436 -0.715842734519139 -1 4.93395346622138 3736 3312 3037 3328 1656 2874 3551 4210 3478 4028 3305 3600 M13872 GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 113/242 Gene Ontology BP GO:0061136 0.000264920691926154 0.000440554001652269 2025 2645.36363636364 3329 2.40865998778797e-05 505 1.09004279795269 -1.12801844730695 -1 4.33354733857757 2021 4223 3329 4252 3881 518 1387 1537 3370 4076 505 3601 M14545 GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. 12/21 Gene Ontology BP GO:2000773 0.000634312417231854 0.000988956532306077 3580 2802.54545454545 3329 5.76813980429143e-05 321 3.29050979313023 -1.02225042359124 -1 11.7127828688059 3576 3404 2020 2693 3507 4148 4028 747 321 3055 3329 3602 M11293 GO_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 305/702 Gene Ontology BP GO:0030163 0.0133926057873846 0.0175012295724252 3320 3255.27272727273 3331 0.00122498505340245 932 1.42270105522936 -1.09497462843383 -1 2.96105396705565 3320 4403 3345 4563 3331 932 3067 4023 2868 4092 1864 3603 M14426 GO_GROOMING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROOMING_BEHAVIOR.html The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. 6/18 Gene Ontology BP GO:0007625 0.0765897756730953 0.0916038970762961 3425 2973.54545454545 3331 0.00793650793650794 1199 1.88334739059369 -1.21322088816983 -1 2.31601610948971 3424 2077 4235 1794 3707 3331 4357 2850 1199 2190 3545 3604 M10906 GO_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_SECRETION.html The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. 15/51 Gene Ontology BP GO:0030073 0.00649567357472354 0.00882112091472402 4280 3643.90909090909 3332 0.000592266565304359 2462 1.49015104587604 -1.31913066419701 -1 3.62668062396251 4279 3290 2462 3092 3246 4529 4070 4290 3129 3332 4364 3605 M15498 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 20/37 Gene Ontology BP GO:1900101 0.0046255020106179 0.00639934619645379 3720 3592.81818181818 3332 0.000421386895943579 2805 0.804446243144562 -0.834170778680909 -1 2.09066553513024 3718 3797 3057 3332 3188 2805 3104 4616 4292 4559 3053 3606 M13409 GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. 2/12 Gene Ontology BP GO:0070897 0.0137668551048211 0.0179751148064354 3300 3433.4 3333 0.00153909183279163 2418 0.568223240391573 0.568223240391573 1 1.17482616385604 3297 2418 4070 NA 3366 3300 3066 3082 3871 4407 3457 3607 M15415 GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. 6/13 Gene Ontology BP GO:1904293 0.0124782476475565 0.0163662440190974 2520 3030.54545454545 3334 0.00125488744450098 1292 0.711158932338288 -0.711158932338288 -1 1.50465916905033 2520 3417 4401 3803 3334 1292 1532 2457 4399 4550 1631 3608 M13102 GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS.html Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 92/252 Gene Ontology BP GO:0010565 0.000112869865315914 0.000202259662162019 4475 3294 3335 1.02614233147364e-05 2136 1.62858038418892 1.95048002992727 1 7.12680302568384 4471 3335 2635 2228 2462 3110 4168 3423 2136 3885 4381 3609 M10361 GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. 9/20 Gene Ontology BP GO:0002861 0.0127868566914133 0.0167568093757358 4200 3131.27272727273 3336 0.00128610347867635 1666 1.61356377648607 1.00351060143571 1 3.39437792493697 4200 2732 3573 3568 3336 4592 1983 1896 1666 2668 4230 3610 M14570 GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 15/48 Gene Ontology BP GO:0006509 0.00300932236852781 0.00423916376124836 3995 3240.36363636364 3337 0.000273949694727927 704 2.68235053069596 3.49514750259398 1 7.53945565774395 3992 3800 1996 3273 3122 4129 4627 2660 704 3337 4004 3611 M16695 GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERAD pathway. 10/17 Gene Ontology BP GO:1904294 0.0839184282471183 0.0949861682962873 3340 3316.54545454545 3338 0.00793650793650794 2673 1.07174753105267 -0.775004263107643 -1 1.29797171132922 3338 2673 2782 3739 3640 3657 3536 3224 3076 2846 3971 3612 M11464 GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. 5/20 Gene Ontology BP GO:0007216 0.0293321405265729 0.0371391132983033 2260 2922.18181818182 3339 0.00297266580135198 1067 1.75535925175432 1.75535925175432 1 2.97393223044125 2260 3539 3751 3339 3916 2106 1067 3950 3683 2976 1557 3613 M16310 GO_ALKALOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). 7/31 Gene Ontology BP GO:0009820 0.314207361389253 0.338798137234162 2560 3432.81818181818 3339 0.0370155331791654 2457 0.925269316337769 -0.925269316337769 -1 0.515225327564423 2556 3299 4545 3452 4377 2457 3729 3339 4227 3302 2478 3614 M16621 GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. 11/24 Gene Ontology BP GO:0043011 0.00564391078736898 0.00772315879332572 4020 3175.36363636364 3339 0.000514403815622599 1159 1.28399029006464 -1.35564187073508 -1 3.21274079163918 4018 3018 2679 2769 3957 3991 4156 1159 3339 2248 3595 3615 M16501 GO_RESPONSE_TO_UV_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_B.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. 7/19 Gene Ontology BP GO:0010224 0.0765897756730953 0.0916038970762961 3565 3429.63636363636 3341 0.00793650793650794 2410 1.69078576916083 2.13048613753596 1 2.07921638609675 3562 3129 4572 3257 4313 3910 3341 2733 2436 2410 4063 3616 M14112 GO_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. 7/25 Gene Ontology BP GO:0019433 0.0765897756730953 0.0916038970762961 2125 3436 3342 0.00793650793650794 2121 3.10979094994676 3.10979094994676 1 3.82421641155851 2121 4210 4189 4000 4061 3313 3457 3037 3342 3286 2780 3617 M14934 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. 22/45 Gene Ontology BP GO:0006383 0.00780073105748012 0.01049515917122 1255 2551.81818181818 3342 0.0007116844433181 704 0.773949670063633 -0.773949670063633 -1 1.81442332501136 1252 3433 3342 3828 4120 704 1102 1280 3630 3956 1423 3618 M10758 GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 59/128 Gene Ontology BP GO:0006661 0.00259003659855083 0.00368091212949847 2525 3237.36363636364 3343 0.000235735532392564 1810 0.918734908408655 -0.940006246506442 -1 2.64908910770403 2522 4183 3343 4466 3100 1838 4002 2533 3807 4007 1810 3619 M14501 GO_CELLULAR_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. 80/207 Gene Ontology BP GO:0009267 2.70958595965137e-05 5.75664426203342e-05 4310 3126.09090909091 3343 2.46329030209079e-06 1751 1.71518079216812 2.23894342517773 1 8.6146259918532 4309 4470 1751 4303 2055 1880 3717 2951 2070 3538 3343 3620 M10793 GO_POSITIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BINDING.html Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 96/216 Gene Ontology BP GO:0051099 4.26803506512046e-06 1.24085703239538e-05 2705 3207.81818181818 3344 3.88003940472637e-07 1505 1.34595730166552 1.60276102406188 1 7.82278629378991 2702 3361 2801 3720 1505 3721 2693 4374 3295 3770 3344 3621 M11899 GO_ADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. 24/64 Gene Ontology BP GO:0046031 0.0839184282471183 0.0949861682962873 2825 3296.90909090909 3346 0.00793650793650794 2773 1.27598650522409 -1.19872822003557 -1 1.54532171365739 2824 2973 2773 3346 3719 3878 2813 3981 2839 3445 3675 3622 M12523 GO_L_ASCORBIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 9/12 Gene Ontology BP GO:0019852 0.0132652109634844 0.0173396324615591 2850 3191.09090909091 3346 0.00133450673019649 2283 1.58101691001245 1.88297446049977 1 3.29810071780956 2847 3443 3923 3996 3346 3203 2283 2771 2359 3492 3439 3623 M14274 GO_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_SECRETION.html The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 23/87 Gene Ontology BP GO:0050663 0.000765128274871514 0.00117282620674429 3540 3159.18181818182 3346 6.95813186444032e-05 1869 1.33402393677246 -1.09976267396122 -1 4.63151165250697 3145 4035 1869 3538 2872 3429 2171 3540 3906 2900 3346 3624 M16422 GO_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING_BY_RNA.html Any process in which RNA molecules inactivate expression of target genes. 74/163 Gene Ontology BP GO:0031047 0.00385449156317713 0.00536784772880366 2350 3400.72727272727 3346 0.000351023764009923 2348 1.3226424986705 -1.10213238987069 -1 3.55700481412244 2348 4541 3346 4137 3171 2703 3400 3169 3553 4030 3010 3625 M13388 GO_AMINO_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_METABOLIC_PROCESS.html The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. 20/46 Gene Ontology BP GO:0006040 0.0146762642117495 0.0191087758651579 2870 3446.72727272727 3347 0.00134319038701315 2463 1.29021908720578 1.359494237111 1 2.62698943732733 2870 3315 2463 3993 3347 4073 3143 3820 3922 3203 3765 3626 M13592 GO_HEART_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_FORMATION.html The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. 8/18 Gene Ontology BP GO:0060914 2.10548482080869e-05 4.6529110057186e-05 3545 2813.36363636364 3347 2.1055047698732e-06 482 2.22398616114725 -1.99570160159712 -1 11.4136922973148 3544 482 4100 2197 2004 3533 4220 3347 2225 1747 3548 3627 M16504 GO_AUTOPHAGOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. 29/52 Gene Ontology BP GO:1905037 0.00642574668026651 0.00873638121126718 3705 3375.90909090909 3347 0.00058587200621168 2620 1.20334254325555 0.812623833512256 1 2.93463117771105 3705 3858 2902 3735 3242 2620 4283 3509 2737 3347 3197 3628 M10358 GO_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. 20/56 Gene Ontology BP GO:0097028 0.0596023548709981 0.0728630157098589 3290 3211 3348 0.00557101189483715 2093 1.56167298165994 1.69902705560985 1 2.10434300047996 3286 3862 2199 3079 3553 3812 2093 4449 3348 2133 3507 3629 M14138 GO_REGULATION_OF_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. 6/19 Gene Ontology BP GO:0033127 0.106913733803185 0.120252050883767 2475 3288.36363636364 3348 0.0112435237735345 2473 0.984715690452284 0.984715690452284 1 1.07308084488624 2473 3102 4190 3348 3652 2895 3417 3378 3648 3145 2924 3630 M14820 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. 15/39 Gene Ontology BP GO:0006360 0.0464979401282321 0.0574939909495024 1795 2910.63636363636 3349 0.00431916307118448 1100 0.669270521713079 -0.669270521713079 -1 0.98340621970132 1792 3913 3349 3970 4083 1100 1247 1806 4340 4502 1915 3631 M13452 GO_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that modulates the amount of sodium excreted in urine over a unit of time. 8/27 Gene Ontology BP GO:0035813 0.00139372434094222 0.00204715663239314 3885 3199.81818181818 3350 0.000139459922368536 1746 2.46519314795898 -2.08598952421776 -1 7.8522725006929 3883 2414 4076 2325 3002 3686 4149 3350 2668 1746 3899 3632 M11765 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 9/20 Gene Ontology BP GO:0034383 0.159760074086916 0.177639272058002 2835 3256.81818181818 3351 0.0172561574047137 1910 1.04058000750303 1.04805180642312 1 0.925083481714053 2834 3351 3801 3000 4040 3778 4189 2181 4075 1910 2666 3633 M10847 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. 8/15 Gene Ontology BP GO:0043923 0.0178131213508087 0.0230187371087684 2050 2918.54545454545 3352 0.0017957541615953 695 0.844828180534861 0.744644446961194 1 1.63922412906741 2046 3352 3647 3634 4467 1864 695 2761 3934 3365 2339 3634 M14502 GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. 14/30 Gene Ontology BP GO:0098927 0.0850435892430726 0.0962128130739732 2830 3228.36363636364 3352 0.00804734114042347 1817 0.667340959710878 -0.667340959710878 -1 0.803797135667589 2830 3865 3122 3943 4014 1924 1817 3352 4281 4482 1882 3635 M15534 GO_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERAD_PATHWAY.html The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. 44/99 Gene Ontology BP GO:0036503 0.000297246264636812 0.000489575880350733 3355 2557.27272727273 3352 2.70260394322085e-05 280 0.875668970187477 -0.926741046648611 -1 3.43375621158222 1278 4333 3352 3979 3354 280 894 1838 4211 4088 523 3636 M12193 GO_SEXUAL_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEXUAL_REPRODUCTION.html A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. 320/1219 Gene Ontology BP GO:0019953 3.80028103253423e-06 1.13107082269592e-05 3355 3292.90909090909 3353 3.45480690650668e-07 1466 1.52589422992216 -1.31847580557852 -1 8.94131426977522 3353 4318 2327 3744 1466 4414 2977 3882 2508 3313 3920 3637 M14724 GO_UBIQUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. 9/13 Gene Ontology BP GO:0006743 0.0169220684868942 0.0219283181648478 2375 3281.36363636364 3353 0.00170523270744122 2374 0.640819186398468 -0.640819186398468 -1 1.25938356163279 2374 3503 4282 3265 3379 2857 3353 2460 3715 4496 2411 3638 M16920 GO_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. 54/127 Gene Ontology BP GO:0007030 4.77666113869136e-05 9.42943778356461e-05 2440 2864.36363636364 3353 4.34251350288143e-06 903 1.09754569308009 -0.935653219589298 -1 5.23385799277185 2437 4421 3353 4498 2231 903 3433 1438 3388 3972 1434 3639 M13169 GO_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium. 26/89 Gene Ontology BP GO:0003341 0.019408592650861 0.0249623533733927 2555 3153.36363636364 3354 0.00178017836763777 1482 1.33189917545028 -1.93887399982032 -1 2.52874665724403 3354 3907 2551 3412 3635 3225 4344 1482 2618 3604 2555 3640 M11047 GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. 87/342 Gene Ontology BP GO:0050851 0.00611211510174213 0.00831484043873094 2215 2958.54545454545 3355 0.000557196575563865 928 1.29964932477021 -1.17904007141543 -1 3.20256456395999 2213 3994 3236 3847 4542 928 1849 3598 3355 3909 1073 3641 M12879 GO_REGULATION_OF_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXCRETION.html Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. 8/33 Gene Ontology BP GO:0044062 0.00139372434094222 0.00204715663239314 3885 3190 3355 0.000139459922368536 1743 2.46519314795898 -2.08598952421776 -1 7.8522725006929 3882 2413 3974 2324 3001 3685 4148 3355 2667 1743 3898 3642 M13056 GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. 6/38 Gene Ontology BP GO:0071875 0.00112414927856827 0.00167289266038221 2440 3074.45454545455 3355 0.00011247183539899 864 1.0818214294583 1.0818214294583 1 3.55824745744892 2436 3450 4001 3355 3469 3839 3127 864 3509 3133 2636 3643 M16898 GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS.html A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. 24/66 Gene Ontology BP GO:0061640 0.00973093316853092 0.0129309452494245 3470 2997.45454545455 3355 0.000888567544575189 1092 3.24842941945222 -1.48156696483023 -1 7.2667206587902 3467 3368 1512 3110 3295 4530 3854 1938 1092 3451 3355 3644 M10928 GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 13/28 Gene Ontology BP GO:0015986 0.204112007912072 0.224465194868724 1670 3076.09090909091 3356 0.0205403687194993 1668 0.390515569100679 -0.390515569100679 -1 0.300164268937523 1668 4444 3356 3672 3733 1819 1723 2453 4376 4231 2362 3645 M13622 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 4/15 Gene Ontology BP GO:0010867 0.00512970628637904 0.00706323436763283 3360 3502.09090909091 3356 0.000514158614900354 2179 1.05375072798688 1.05375072798688 1 2.68506867167222 3356 2179 4107 2905 3229 4459 3926 3329 4198 2789 4046 3646 M11547 GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 342/771 Gene Ontology BP GO:0010638 2.87631694738995e-07 2.19289648386397e-06 3615 3175 3357 2.61483393040412e-08 420 1.55152966588191 1.79669143239431 1 10.4010316471193 3612 4049 2334 3336 420 2956 4218 4268 2190 3357 4185 3647 M12843 GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. 13/28 Gene Ontology BP GO:0015985 0.204112007912072 0.224465194868724 1670 3100 3357 0.0205403687194993 1669 0.390515569100679 -0.390515569100679 -1 0.300164268937523 1669 4445 3357 3673 3734 1820 1724 2577 4377 4361 2363 3648 M13489 GO_LIPID_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSLOCATION.html The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. 10/30 Gene Ontology BP GO:0034204 0.0204007613912487 0.0261804132502951 4210 2985.81818181818 3357 0.00187203928555523 1134 2.828282253538 2.6412465055324 1 5.30046100071051 4208 2361 1375 2356 3393 3976 4402 3357 1134 2070 4212 3649 M16555 GO_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING.html Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 28/70 Gene Ontology BP GO:0060968 0.0839184282471183 0.0949861682962873 2710 3493 3357 0.00793650793650794 2707 1.61997342603343 -1.64787949494434 -1 1.9619178408571 2707 4556 2993 4323 4367 3108 3357 2785 3625 3683 2919 3650 M14123 GO_RNA_SECONDARY_STRUCTURE_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SECONDARY_STRUCTURE_UNWINDING.html The process in which a secondary structure of RNA are broken or 'melted'. 22/45 Gene Ontology BP GO:0010501 0.216725243616163 0.237324364648549 1820 3307.90909090909 3358 0.0219617722533297 1713 0.707991537080542 -0.707991537080542 -1 0.523898135784027 1820 4437 3358 4416 4184 1713 1950 3059 4425 4454 2571 3651 M13353 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION.html Any recombinational process that contributes to the maintenance of proper telomeric length. 18/33 Gene Ontology BP GO:0000722 0.750509278595909 0.776948624419354 3915 3395.27272727273 3360 0.118572160214938 1548 0.614151067372023 -0.614151067372023 -1 0.0797416485443101 1548 3912 3241 3912 4361 2562 2508 3360 4461 4400 3083 3652 M10113 GO_LIPID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_MODIFICATION.html The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. 110/244 Gene Ontology BP GO:0030258 4.12805391357416e-06 1.21077412007106e-05 4580 3442.27272727273 3361 3.75278332675084e-07 1492 1.42994403685115 1.61533135021529 1 8.32897746971459 4578 3239 2260 3745 1492 3361 4522 4596 2885 3028 4159 3653 M13892 GO_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BIOSYNTHETIC_PROCESS.html The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 63/137 Gene Ontology BP GO:0071897 0.456417398106018 0.48477063954027 1480 3258.27272727273 3361 0.0539083017824259 1480 1.02846514841519 -0.782569638528741 -1 0.383121286880825 1480 4331 3361 4329 4143 2135 2044 2862 4036 4108 3012 3654 M10697 GO_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_DNA_REPLICATION.html The DNA-dependent DNA replication that takes place as part of the cell cycle. 4/13 Gene Ontology BP GO:0044786 0.892605953883488 0.912053134656918 3365 3501.18181818182 3362 0.19998520160981 2806 0.789619679568588 -0.789619679568588 -1 0.0373953670452183 2806 3301 3620 3364 4210 2958 2875 3362 4455 4215 3347 3655 M12055 GO_NUCLEAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSPORT.html The directed movement of substances into, out of, or within the nucleus. 218/481 Gene Ontology BP GO:0051169 0.0839184282471183 0.0949861682962873 2745 3368.18181818182 3362 0.00793650793650794 2119 1.40616702920282 -1.52986806305235 -1 1.70298091185821 2744 4589 3450 4436 4479 2119 3179 2505 3362 4022 2165 3656 M14329 GO_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE.html Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. 505/1745 Gene Ontology BP GO:0006955 3.66644258049387e-07 2.53906434788708e-06 3720 2691.09090909091 3362 3.66644318542007e-08 420 1.59924175116912 -1.37819216902751 -1 10.6002856776508 3720 868 4225 1470 556 3362 4410 3859 2370 420 4342 3657 M15151 GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 12/23 Gene Ontology BP GO:0042776 0.531403496863589 0.560242151666132 2030 3371.81818181818 3362 0.0665895895763988 2026 0.390515569100679 -0.390515569100679 -1 0.116402583575105 2026 4499 3362 3785 3951 2235 2090 3342 4526 4525 2749 3658 M16760 GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 121/280 Gene Ontology BP GO:0009895 7.37232267877823e-07 3.60312570500709e-06 4215 3317.27272727273 3362 6.70211377207803e-08 829 1.28928938313509 -1.21601972823868 -1 8.31366141296027 4215 3902 2657 4180 829 2833 4195 3302 3120 3895 3362 3659 M15653 GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE.html The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. 22/47 Gene Ontology BP GO:0042769 0.759207097711103 0.785427485443996 2970 3663.72727272727 3363 0.121410944067474 2675 0.71112730430769 -0.71112730430769 -1 0.0883623879235508 2969 4385 3363 4424 4191 2675 2818 3038 4562 4570 3306 3660 M10727 GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. 8/15 Gene Ontology BP GO:0045779 0.0549398645729889 0.0674473271317788 2725 3204.45454545455 3364 0.00563473679672489 1790 0.99772140124993 -0.99772140124993 -1 1.38406610294838 2722 2365 3626 3515 4141 2774 4433 1790 3961 3364 2558 3661 M15461 GO_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECOMBINATIONAL_REPAIR.html A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. 48/92 Gene Ontology BP GO:0000725 0.596188979844879 0.624572525591104 1545 3418.09090909091 3364 0.0791306565479705 1545 0.674110450586683 -0.605919459279618 -1 0.163238261567748 1545 4121 3364 4333 4185 2494 2631 2815 4507 4554 3050 3662 M10644 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process. 120/244 Gene Ontology BP GO:1903364 0.0839184282471183 0.0949861682962873 2760 3298.90909090909 3365 0.00793650793650794 1755 1.19823572867239 -1.09690371481055 -1 1.45115920212353 2756 4467 3365 4140 4326 1755 2784 3001 3469 4115 2110 3663 M13445 GO_LIVER_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIVER_REGENERATION.html The regrowth of lost or destroyed liver. 12/26 Gene Ontology BP GO:0097421 0.186591813983095 0.205978552620902 2675 3259.63636363636 3366 0.0185995996797219 2205 0.85091682081922 0.885992152796278 1 0.691673191076582 2675 2761 2916 3366 3726 3908 3399 2205 3967 3699 3234 3664 M15525 GO_CARDIAC_CHAMBER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_FORMATION.html The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. 6/19 Gene Ontology BP GO:0003207 4.88999305097072e-06 1.37684886207744e-05 3890 2780 3367 4.89000381141846e-07 908 1.91034280376963 2.21943957281168 1 11.0008216533507 3890 948 4418 1929 1580 4164 4601 3462 908 1313 3367 3665 M11456 GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. 95/214 Gene Ontology BP GO:1901293 1.41728321173474e-05 3.31341689430231e-05 3695 3365 3368 1.28844758384901e-06 1864 1.17594154490327 -0.9865809507287 -1 6.24043649537147 3694 3334 2856 3873 1864 2836 3293 4510 3368 3725 3662 3666 M11920 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. 33/99 Gene Ontology BP GO:1990542 0.405898595646998 0.43403666043045 3040 3578.45454545455 3368 0.0462339248047254 2561 0.597437867155022 -0.497189144113199 -1 0.256533664936444 3038 4553 3337 4136 4284 2793 2788 2561 4210 4295 3368 3667 M12877 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS.html The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. 68/130 Gene Ontology BP GO:0090501 0.0599552655796185 0.0732365951292209 4610 3125.81818181818 3368 0.00560494381902864 1788 1.18443488550897 -1.15259036066267 -1 1.59290070548653 1968 4606 3368 4606 3708 1863 2524 1788 3547 4046 2360 3668 M16332 GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. 24/56 Gene Ontology BP GO:1904031 0.0172770147812375 0.0223633062808156 4135 3282.54545454545 3368 0.00158310956011167 1937 1.06465861444573 0.937902683249146 1 2.08158512636494 4131 3598 2729 2886 3368 3309 3108 1937 3591 3450 4001 3669 M11237 GO_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_TRANSPORT.html The directed movement of substances into, out of or within a vacuole. 156/316 Gene Ontology BP GO:0007034 0.00363210525436378 0.00507336483032823 1390 2696.09090909091 3370 0.000330737781842247 557 1.08813881854558 -1.06051610853321 -1 2.95793627444068 1388 3851 3370 4086 4036 557 1176 2323 3490 3739 1641 3670 M14341 GO_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_APOPTOTIC_PROCESS.html Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 31/69 Gene Ontology BP GO:0051402 6.99685672017593e-05 0.000131790692704977 4075 3308.36363636364 3370 6.36098114306846e-06 1389 1.38479640421508 -1.10232699922157 -1 6.36514850552452 4071 3177 2384 3370 2340 4526 4603 2543 1389 3773 4216 3671 M11510 GO_NEGATIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. 8/18 Gene Ontology BP GO:0046851 0.0566689343335262 0.0694415049117345 2725 3219 3372 0.00581681453248427 1800 0.99772140124993 -0.99772140124993 -1 1.36910966144906 2723 2366 3760 3516 4142 2775 4434 1800 3962 3372 2559 3672 M14880 GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that stops or reduces the activity of a monooxygenase. 5/24 Gene Ontology BP GO:0032769 0.000169791258210223 0.000292628363723113 3445 3377.54545454545 3372 1.69804232687563e-05 2324 1.05881226366842 -0.660197797417513 -1 4.43225316025755 3444 2967 4309 3310 2574 3372 2324 4529 3724 2998 3602 3673 M15179 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 13/18 Gene Ontology BP GO:0045717 0.00175046559976131 0.00253743733365337 3715 3370.27272727273 3372 0.000159259994499021 2512 0.996329883020961 -0.859288211643738 -1 3.06351186884334 3714 3377 2989 3372 3032 2512 3147 4033 4104 3757 3036 3674 M12320 GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). 25/43 Gene Ontology BP GO:0006891 0.000458128576572372 0.000731210375051744 3140 3408.45454545455 3373 4.16567277463e-05 2234 0.618311577162683 -0.618311577162683 -1 2.29697015146806 3138 3545 3373 4036 2756 2970 3265 3522 4324 4330 2234 3675 M15048 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSMEMBRANE_TRANSPORT.html The directed movement of a protein across a membrane by means of some agent such as a transporter or pore. 35/79 Gene Ontology BP GO:0071806 0.0120809564029008 0.0158675758355498 2155 3022 3374 0.00110434651194072 783 0.651649759078716 -0.595051769078209 -1 1.3891243107714 2153 4335 3374 4253 4151 783 1258 2569 4414 4519 1433 3676 M15474 GO_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of DNA replication. 86/211 Gene Ontology BP GO:0006275 0.0839184282471183 0.0949861682962873 3375 3571.90909090909 3374 0.00793650793650794 2332 1.54334316854685 -1.24406131903275 -1 1.86911236900917 3374 4536 2709 4381 4374 2332 3194 4219 3346 3901 2925 3677 M15581 GO_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 8/25 Gene Ontology BP GO:0000305 0.0700142348261329 0.0850539226315372 2695 3190.45454545455 3374 0.00723231990906118 1032 0.745690824888046 -0.745690824888046 -1 0.945461715230836 2691 3021 4428 3374 3826 1342 1032 4106 4404 4566 2305 3678 M11639 GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. 72/188 Gene Ontology BP GO:0034249 0.00126503213791903 0.00187294139552234 3375 3240.45454545455 3375 0.000115069103272627 1908 1.72241464345495 -1.46210272390821 -1 5.56514631836606 3375 4417 2879 3907 2960 1908 3681 3988 2448 3458 2624 3679 M11789 GO_SEQUESTERING_OF_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUESTERING_OF_METAL_ION.html The process of binding or confining metal ions such that they are separated from other components of a biological system. 8/22 Gene Ontology BP GO:0051238 0.0322376678641774 0.0406627253174072 3325 3259.72727272727 3376 0.00327151155639901 2143 1.50166964206335 -0.57847318031523 -1 2.47410420759408 3322 3869 3805 2294 3468 3927 4340 2143 2478 3376 2835 3680 M12021 GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition. 38/93 Gene Ontology BP GO:1902749 0.0578122988710733 0.0707678628152896 2425 3200.90909090909 3376 0.0053990783164021 1781 1.77186917543518 2.18740769338182 1 2.41417746618198 2421 4185 2518 3722 3720 3756 3824 1781 2834 3073 3376 3681 M12380 GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. 61/149 Gene Ontology BP GO:0002220 0.0233095395922248 0.0297488159226773 1960 2912 3376 0.00214183968486429 977 0.981252346393087 -1.13202511461303 -1 1.77445026694431 1958 4420 3376 4264 4508 977 1231 1667 4121 4064 1446 3682 M11633 GO_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_SECRETION.html The controlled release of a peptide from a cell or a tissue. 27/82 Gene Ontology BP GO:0002790 0.0839184282471183 0.0949861682962873 3345 3430.90909090909 3377 0.00793650793650794 1574 1.82352323943071 2.02528026952419 1 2.2084332134591 3341 3712 1574 3771 4583 4175 3213 3377 3259 2744 3991 3683 M11925 GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 8/23 Gene Ontology BP GO:0071732 0.16101401918791 0.178875942577683 1545 2881.81818181818 3377 0.0174029172938202 1354 2.44289800522702 2.44289800522702 1 2.16303785813712 1543 3985 3825 3473 3888 1775 1354 2214 4099 3377 2167 3684 M12324 GO_ANATOMICAL_STRUCTURE_REGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_REGRESSION.html The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. 9/20 Gene Ontology BP GO:0060033 0.397866434593948 0.425741842779373 2900 3406.09090909091 3377 0.0494624372372997 2593 0.916564576998834 -0.790776269138314 -1 0.402663191316087 2899 3672 3890 3377 4408 2889 2824 2593 4130 3491 3294 3685 M11260 GO_TELOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. 63/120 Gene Ontology BP GO:0032200 0.285985731564808 0.309229564894132 1120 3168 3379 0.0301588069248043 1118 0.822668206370368 -0.874044894701268 -1 0.49674346142366 1118 4422 3379 4432 3915 1855 2192 2557 4286 4107 2585 3686 M12372 GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 29/55 Gene Ontology BP GO:0006220 0.770426114418707 0.795969837393426 4320 3563.90909090909 3379 0.125213556733233 2623 0.601214414550546 -0.571605558015385 -1 0.0705806486445935 2623 4060 3235 4316 4041 2683 2931 3379 4317 4333 3285 3687 M10491 GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. 151/367 Gene Ontology BP GO:0032886 0.0839184282471183 0.0949861682962873 4275 3450.36363636364 3380 0.00793650793650794 2189 1.4305091257203 1.80359269219841 1 1.7324611697507 2310 4526 3091 4275 4274 3716 2752 2189 3380 4085 3356 3688 M12041 GO_BILE_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. 11/33 Gene Ontology BP GO:0006699 0.00134367679274152 0.00198053693609488 3935 3386 3382 0.000122227105647129 1828 1.70305236673079 2.14334357342294 1 5.45364530143584 3935 3072 1828 2713 2974 4446 3734 3382 3664 2927 4571 3689 M12643 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. 8/15 Gene Ontology BP GO:0071459 0.33296556889208 0.358300306457973 2660 3477.36363636364 3382 0.0396825396825397 2660 1.8818988242565 -1.8818988242565 -1 0.993728481326898 2660 3101 3944 2824 4595 3461 3313 3807 3895 3382 3269 3690 M15290 GO_RESPONSE_TO_EPINEPHRINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPINEPHRINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 7/29 Gene Ontology BP GO:0071871 0.0935014596240993 0.105591244652514 1875 3167.81818181818 3383 0.00976856049403975 1846 0.681378109929211 0.681378109929211 1 0.788098877568943 1874 3383 4381 2793 3625 2053 1846 3595 4297 4541 2458 3691 M11089 GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 175/351 Gene Ontology BP GO:0045732 0.0440000315451538 0.0545506399103202 2810 3169 3384 0.00408231722547151 1086 1.24322287482315 -1.13706720126092 -1 1.86036804092469 2810 4522 3405 4335 4239 1086 2574 2688 3384 4102 1714 3692 M12563 GO_RNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. 61/121 Gene Ontology BP GO:0009451 0.0839184282471183 0.0949861682962873 1545 3183.54545454545 3384 0.00793650793650794 1544 0.922231207104876 -0.941113371577241 -1 1.11689528736741 1544 4330 3384 4580 4396 1870 3140 1972 3605 4100 2098 3693 M15254 GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN.html The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 30/58 Gene Ontology BP GO:0051220 0.000264174770701579 0.000439470963943903 3385 3260.45454545455 3384 2.4018772544934e-05 1234 0.817010877952384 -0.718097254622518 -1 3.2491225230936 3384 4381 3258 4244 2649 1234 2695 4098 4150 3913 1859 3694 M13062 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. 23/35 Gene Ontology BP GO:0000462 0.149907019592509 0.166950897569685 2260 3294.90909090909 3385 0.0146560434048472 1723 0.456256846558562 -0.456256846558562 -1 0.420181158738131 2258 4339 3385 4562 4456 1723 2211 2122 4581 4377 2230 3695 M12099 GO_RESPONSE_TO_MAGNESIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MAGNESIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. 9/45 Gene Ontology BP GO:0032026 0.00341085546616586 0.00477293608481257 2470 3084.54545454545 3386 0.000341610207423802 2019 0.829168117917707 0.829168117917707 1 2.28000410417436 2470 2567 3848 3400 3164 3386 2019 2192 3944 3489 3451 3696 M13085 GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION.html The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. 8/16 Gene Ontology BP GO:0071425 0.0242759168185592 0.0309311420934605 2485 3090 3386 0.00245452613188694 1566 1.53561774604294 -1.53561774604294 -1 2.74614843819391 2483 4015 4009 3946 4273 2045 1721 1566 3924 3386 2622 3697 M10642 GO_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION.html A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 63/129 Gene Ontology BP GO:0006261 0.824128656867417 0.845806665304026 1470 3550.90909090909 3387 0.146150416449641 1467 0.62394265821083 -0.62394265821083 -1 0.0537546691683149 1467 4228 3387 4062 4286 3028 3210 3383 4497 4211 3301 3698 M16958 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 31/73 Gene Ontology BP GO:0090502 0.051149608861327 0.0629606664748519 2705 3383.36363636364 3387 0.00476173063856756 1747 1.12505726913343 -1.12505726913343 -1 1.60055357737509 2701 4619 3234 4556 4438 2427 3387 1747 4116 3931 2061 3699 M12247 GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. 5/14 Gene Ontology BP GO:0045898 0.306729823542753 0.331042903465598 3880 3252.72727272727 3388 0.0359706599278115 1925 0.215390812393529 -0.215390812393529 -1 0.122502580655287 2325 3388 3876 3600 3880 1925 2243 3098 4392 4323 2730 3700 M10831 GO_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. 6/28 Gene Ontology BP GO:0046068 0.214139132665174 0.234658483116451 2785 3352.18181818182 3390 0.0238095238095238 2170 1.84315786579511 -1.2434177263632 -1 1.3746109898256 2784 3724 3643 3161 3900 3283 3917 3390 3781 2170 3121 3701 M11474 GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 5/18 Gene Ontology BP GO:0051571 0.360446597796713 0.387127817157099 2680 3244.54545454545 3390 0.0437142563186421 2014 0.327343607270669 -0.379391240859441 -1 0.159818881087291 2678 3390 3753 3418 4501 2014 2021 2649 4363 4271 2632 3702 M15332 GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 149/352 Gene Ontology BP GO:0010498 0.0839184282471183 0.0949861682962873 2750 3349.18181818182 3390 0.00793650793650794 1476 1.55164901587043 -0.933389613620938 -1 1.87917142538253 2747 4594 3390 4194 4228 1476 2175 4369 3117 4128 2423 3703 M10521 GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 19/37 Gene Ontology BP GO:0006221 0.692967089262386 0.719947683026462 2720 3555.63636363636 3391 0.101784700619033 2717 0.686185989175764 -0.711939850730658 -1 0.115993797924286 2717 4037 2959 4109 4006 2817 3237 3344 4290 4205 3391 3704 M16964 GO_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a higher concentration of a chemical. 24/52 Gene Ontology BP GO:0050918 0.00941051059634092 0.0125446456212492 3510 3244.90909090909 3393 0.000859182438287543 1715 1.4335299745536 -1.15584987807034 -1 3.22916684903409 3506 3149 1715 3482 3290 4117 3393 3537 3285 2041 4179 3705 M14625 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION.html A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. 26/47 Gene Ontology BP GO:0033683 0.0205259418077576 0.0263337794455425 3035 3474.54545454545 3394 0.00188363524578717 2248 0.599319973831381 -0.577895556665327 -1 1.12137844712988 3032 4238 3399 4368 3394 2248 3035 2969 4133 4491 2913 3706 M10874 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. 36/130 Gene Ontology BP GO:0002704 0.0839184282471183 0.0949861682962873 3395 3113.54545454545 3395 0.00793650793650794 1358 1.81218118144212 -1.87251064565659 -1 2.19469705912683 3395 3680 1750 3474 4378 2717 3821 3896 2655 1358 3125 3707 M11104 GO_ATP_GENERATION_FROM_ADP http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_GENERATION_FROM_ADP.html The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. 19/54 Gene Ontology BP GO:0006757 0.0839184282471183 0.0949861682962873 3265 3391 3395 0.00793650793650794 2554 1.41304081877986 -1.19872822003557 -1 1.71130562987436 3261 3287 2554 3395 3740 4111 3004 3413 2905 3621 4010 3708 M13443 GO_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAPPING.html The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. 20/43 Gene Ontology BP GO:0036260 0.131528413690497 0.147330862428222 1755 3061.36363636364 3395 0.0127382106108511 1472 0.662421217630572 -0.662421217630572 -1 0.652651277107236 1751 3832 3395 4239 4022 1472 1719 2491 4154 4410 2190 3709 M13544 GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. 21/62 Gene Ontology BP GO:0000381 0.161385165508919 0.178875942577683 2245 3358.90909090909 3395 0.0158730158730159 2228 1.78339826383907 1.78339826383907 1 1.57909042598693 2244 4491 3097 4237 4530 2228 2368 3395 3726 3938 2694 3710 M14394 GO_7_METHYLGUANOSINE_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_7_METHYLGUANOSINE_RNA_CAPPING.html The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. 20/43 Gene Ontology BP GO:0009452 0.131528413690497 0.147330862428222 1755 3080 3396 0.0127382106108511 1473 0.662421217630572 -0.662421217630572 -1 0.652651277107236 1752 3833 3396 4240 4023 1473 1720 2623 4155 4474 2191 3711 M14864 GO_ERROR_PRONE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_PRONE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 8/25 Gene Ontology BP GO:0042276 0.0493815574880299 0.0609135418217117 1655 2867.63636363636 3397 0.00505144970561792 1651 0.968751507107648 -0.968751507107648 -1 1.39466055120351 1651 3561 4307 3524 3737 2030 2396 1813 3397 3401 1727 3712 M16191 GO_PEPTIDYL_LYSINE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_METHYLATION.html The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. 38/84 Gene Ontology BP GO:0018022 0.0135525420899048 0.01770048053345 2505 3055.81818181818 3398 0.00123970511655537 895 0.692024378664173 -0.667229115535331 -1 1.43627232811026 2504 4618 3398 4612 4330 895 1226 2404 4265 4067 1295 3713 M10566 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. 17/40 Gene Ontology BP GO:0051154 6.01962507618854e-05 0.000115301646983265 4530 3052 3399 5.47253617370113e-06 1610 1.72422416571308 -1.95086606604532 -1 8.04388013278698 4530 3435 1610 3399 2299 4106 4256 1655 2513 1787 3982 3714 M10239 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of mRNA metabolic process. 72/183 Gene Ontology BP GO:1903311 0.466738071388703 0.4949590645891 2965 3514.81818181818 3400 0.0555555555555556 2249 1.55159414321148 -1.43569208289768 -1 0.561393842679771 2965 4542 3400 4337 4497 2249 2859 2888 3976 4096 2854 3715 M13638 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS.html The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 20/43 Gene Ontology BP GO:0002200 0.0839184282471183 0.0949861682962873 3255 3568.27272727273 3400 0.00793650793650794 2982 0.940860079038774 -0.654804229091331 -1 1.13945636580464 3251 3400 2982 4446 3849 3127 3267 4122 3186 3920 3701 3716 M10557 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. 7/24 Gene Ontology BP GO:0032692 0.00185967398675611 0.0026840119118771 2765 3227.09090909091 3401 0.000186123209650248 962 1.03312111304555 -1.03312111304555 -1 3.14678878942599 2765 3645 3602 3754 3401 3046 4602 962 4060 3269 2392 3717 M13966 GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of T cell proliferation. 42/104 Gene Ontology BP GO:0042130 0.0255061346346721 0.0324629887907847 3405 3357 3401 0.00234606687466808 1764 1.70990068949469 -1.75000662103094 -1 3.01529714210973 3401 3365 1764 3309 3422 4135 3526 4643 2758 2611 3993 3718 M13293 GO_ELECTRON_TRANSPORT_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_TRANSPORT_CHAIN.html A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 52/110 Gene Ontology BP GO:0022900 0.0839184282471183 0.0949861682962873 1855 3206.18181818182 3402 0.00793650793650794 1693 1.16899748402825 -0.792939355800927 -1 1.41574931079333 1854 4277 3402 4049 3977 2148 1693 3852 3249 4069 2698 3719 M14421 GO_KETONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 17/38 Gene Ontology BP GO:0042181 0.000544297887923214 0.000859291089298702 4260 3410.36363636364 3402 4.94938725734941e-05 1788 1.34051931739099 -0.678004910516794 -1 4.86859113496804 4258 3402 2715 2907 2786 3318 4334 3782 1788 3867 4357 3720 M14943 GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. 8/29 Gene Ontology BP GO:1900271 0.0143765422194657 0.0187395523652384 1800 2967.54545454545 3402 0.00144704062344691 892 0.932152918716796 0.932152918716796 1 1.90729454842509 1798 4448 4322 4099 3982 1622 892 1419 4318 3402 2341 3721 M15553 GO_GMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GMP, guanosine monophosphate. 9/27 Gene Ontology BP GO:0046037 0.000802853371721928 0.00122660705360159 1205 2588.81818181818 3402 8.03143577386188e-05 754 0.734190831707027 -0.734190831707027 -1 2.53205372525296 1203 3532 4420 3935 3402 879 841 807 4143 4561 754 3722 M13743 GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 253/528 Gene Ontology BP GO:0042176 0.00271784427890947 0.00385429168814192 2640 3034.18181818182 3403 0.000247382516196916 516 1.21433331365326 -1.08727013937424 -1 3.47266617730498 2637 4519 3441 4274 4480 516 2366 2406 3403 4149 1185 3723 M16031 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. 29/70 Gene Ontology BP GO:0042273 0.464437109608263 0.492999885667847 1940 3367.63636363636 3403 0.0551858105887042 1937 0.774938011584202 -0.774938011584202 -1 0.281966486981623 1937 4158 3403 4373 4081 2145 2005 3184 4354 4586 2818 3724 M15991 GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of autophagosome assembly. 24/43 Gene Ontology BP GO:2000785 0.000244244502884031 0.000409839980806127 3405 3295.18181818182 3404 2.22065111981752e-05 2631 1.16604699296241 -1.00936293527587 -1 4.67906034019058 3404 3429 2924 3802 2631 3113 3582 3703 2954 3449 3256 3725 M13856 GO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING.html The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. 105/235 Gene Ontology BP GO:0006457 0.00054031686312635 0.000854167924921908 3405 3448.54545454545 3405 4.91317827111931e-05 2782 1.26420887147266 1.50830156195738 1 4.59533081389422 3405 3516 3291 2911 2782 4226 4308 3246 3046 3523 3680 3726 M11645 GO_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 20/62 Gene Ontology BP GO:0043330 0.00663660660099306 0.00899671954698125 3410 3391.81818181818 3406 0.000605155619214084 2849 1.03130726441851 -0.788776389810414 -1 2.49950290786984 3406 3714 2849 3493 3251 3099 3907 3611 3554 3201 3225 3727 M14119 GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a virus effects a change in the structure or processes of its host organism. 27/58 Gene Ontology BP GO:0019048 0.00201804199439112 0.00290085726933683 3585 3506.90909090909 3406 0.000183626864412002 2165 1.94365685112716 -1.63453997217582 -1 5.84250522416283 3581 4622 2165 4108 3058 4581 4127 3019 2689 3220 3406 3728 M10044 GO_TRNA_AMINOACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_AMINOACYLATION.html The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. 33/52 Gene Ontology BP GO:0043039 0.0916563215217272 0.103542652268949 900 2948.09090909091 3408 0.00870123877197459 897 0.590614067231772 -0.590614067231772 -1 0.689071776197521 897 3964 3408 4528 3897 1324 1787 2126 4261 4181 2056 3729 M11294 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 5/18 Gene Ontology BP GO:0033145 0.159772043961709 0.177639272058002 3125 3286.18181818182 3408 0.0172575574091408 2164 0.521781820512482 -0.521781820512482 -1 0.463867138762655 3124 2648 3726 3408 4455 2238 2602 3664 3860 4259 2164 3730 M15690 GO_REGULATION_OF_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H4_ACETYLATION.html Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. 10/16 Gene Ontology BP GO:0090239 0.0510315930134552 0.0628487231728044 4035 3152.81818181818 3408 0.00475047805050543 1746 3.20906322497892 -3.20906322497892 -1 4.56828885044163 4034 3408 2390 3419 3681 3270 3648 1746 2594 3594 2897 3731 M10357 GO_AMINO_ACID_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_ACTIVATION.html The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. 33/52 Gene Ontology BP GO:0043038 0.0916563215217272 0.103542652268949 900 2953.18181818182 3409 0.00870123877197459 898 0.590614067231772 -0.590614067231772 -1 0.689071776197521 898 3965 3409 4529 3898 1325 1788 2157 4262 4197 2057 3732 M12689 GO_RESPONSE_TO_INACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. 12/23 Gene Ontology BP GO:0014854 0.0839184282471183 0.0949861682962873 2875 3437.09090909091 3409 0.00793650793650794 2700 1.36013756570616 1.3964539094901 1 1.64723548937334 2873 4252 2700 3591 4366 3507 3263 3137 3409 3049 3661 3733 M15280 GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. 899/2144 Gene Ontology BP GO:0071822 8.18269023414493e-07 3.82986197148537e-06 3950 3069 3409 8.18269324718534e-08 904 1.5621220136859 1.85127729877597 1 10.0239094618081 3948 2124 4379 2418 904 3409 4307 3518 2023 2096 4633 3734 M11977 GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS.html The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. 9/17 Gene Ontology BP GO:0016973 0.0107143545367296 0.0141406333467981 1780 2999.09090909091 3410 0.00107663666538865 1380 1.43727136776993 -1.43727136776993 -1 3.14904082613024 1776 3695 3837 4002 3322 1380 2272 3410 3889 3488 1919 3735 M12694 GO_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACETYLATION.html The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic 76/148 Gene Ontology BP GO:0006473 0.0102546244742994 0.0135724690519304 1650 2830.54545454545 3410 0.000936612501972216 787 1.19205613326673 -1.10211252471776 -1 2.63692754391777 1646 4474 3410 4567 3829 787 1826 1792 3596 4002 1207 3736 M11119 GO_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING.html The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. 254/612 Gene Ontology BP GO:0006605 0.00567253921459118 0.00775319386910416 2455 3047.90909090909 3411 0.000517019859899305 640 1.17910186223656 -1.10179512190209 -1 2.94793917710366 2452 4319 3499 4278 3882 640 2457 3255 3411 4121 1213 3737 M16950 GO_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MITOCHONDRION.html The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. 32/69 Gene Ontology BP GO:0006626 0.0172467157835995 0.022330312711448 1990 3158.18181818182 3413 0.00158031115686991 1436 0.814229275305728 -0.760501037443428 -1 1.59257208908284 1987 4620 3413 4582 4457 1803 1989 1436 4080 3947 2426 3738 M14417 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. 30/115 Gene Ontology BP GO:0002707 0.0839184282471183 0.0949861682962873 3500 3169.54545454545 3415 0.00793650793650794 1632 2.03695516592153 -2.0906984750082 -1 2.46691662843212 3498 3791 1849 3228 4478 2896 3815 3906 2357 1632 3415 3739 M16483 GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. 36/79 Gene Ontology BP GO:0006521 0.476146736692652 0.504506914300316 1955 3244.54545454545 3415 0.0570826979792436 1955 0.804858169681809 -0.782801893040202 -1 0.283299357028897 1955 3961 3415 3618 3919 2158 2658 3111 4032 4058 2805 3740 M10103 GO_REGULATION_OF_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GOLGI_ORGANIZATION.html Any process that modulates the frequency, rate or extent of Golgi organization. 7/19 Gene Ontology BP GO:1903358 0.412413809857661 0.440901984611817 2490 3278.45454545455 3416 0.0517842646760709 2394 0.792045513318763 -0.792045513318763 -1 0.333701814044358 2490 3416 3533 4076 4084 2394 3509 2618 4048 3266 2629 3741 M11753 GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. 10/36 Gene Ontology BP GO:0060122 0.0839184282471183 0.0949861682962873 3420 3194.54545454545 3416 0.00793650793650794 1970 1.93799207112203 -1.93799207112203 -1 2.34706427494097 3416 3839 2417 3697 4077 3281 3176 1970 2227 3571 3469 3742 M12761 GO_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_MODIFICATION.html The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. 279/725 Gene Ontology BP GO:0016568 0.0839184282471183 0.0949861682962873 2785 3407.54545454545 3416 0.00793650793650794 1640 1.33526876021786 -0.953608245557287 -1 1.6171173440958 2781 4584 3416 4574 4196 1640 2745 3809 3208 4153 2377 3743 M15710 GO_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLATION.html The covalent attachment and further modification of carbohydrate residues to a substrate molecule. 126/292 Gene Ontology BP GO:0070085 1.18495746796521e-06 4.96304782782855e-06 3915 3281.45454545455 3417 1.0772346420036e-07 1009 1.28884460684129 1.34015523179107 1 8.09846446989093 3911 2773 3092 3676 1009 3417 4405 4185 2590 2510 4528 3744 M11729 GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. 46/110 Gene Ontology BP GO:0033238 0.00189285198461712 0.00273019936768477 3635 3205 3418 0.000172225684978666 2281 1.29231311436487 -0.783239073722862 -1 3.92491960506047 3515 2972 3028 3467 3042 2498 3418 3633 2281 3766 3635 3745 M13395 GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 6/24 Gene Ontology BP GO:0071872 0.0968573504229455 0.10925866812773 2350 3302.63636363636 3418 0.0101357599394309 2347 0.681378109929211 0.681378109929211 1 0.776130131559228 2347 3418 4068 2792 3632 2475 2578 3605 4374 4405 2635 3746 M14704 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE.html The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. 30/50 Gene Ontology BP GO:0006120 0.167861004178419 0.185964839513338 1355 3126.09090909091 3419 0.0165663158079856 1355 0.599647111963757 -0.599647111963757 -1 0.518959869801954 1355 4287 3419 4261 4177 1594 1529 2506 4555 4494 2210 3747 M10864 GO_MATURATION_OF_SSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. 29/44 Gene Ontology BP GO:0030490 0.22986103905546 0.251352992071244 1915 3313.27272727273 3420 0.0234643567744549 1830 0.456256846558562 -0.456256846558562 -1 0.324138662374689 1915 4433 3420 4506 4458 1830 2397 2301 4541 4225 2420 3748 M11655 GO_UV_PROTECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_UV_PROTECTION.html Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. 8/13 Gene Ontology BP GO:0009650 2.31826838073799e-05 5.06051720346332e-05 3550 3303.27272727273 3421 2.31829256575037e-06 1820 0.774688123259483 0.809827323774951 1 3.94229739415647 3549 1820 3784 2814 2028 4505 4448 2648 3421 3375 3944 3749 M10844 GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 141/312 Gene Ontology BP GO:0034976 1.24217172177541e-06 5.14946723589573e-06 4335 3353.54545454545 3422 1.12924765739574e-07 1027 1.12760617705453 -0.970726998546493 -1 7.06393041639338 4334 3422 3330 4241 1027 2698 4177 3823 3026 4061 2750 3750 M11137 GO_POLYOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 11/24 Gene Ontology BP GO:0046174 0.286324987745965 0.309524311549364 3330 3336.54545454545 3422 0.0302007077555608 1860 0.791447339955088 -0.818352700937134 -1 0.477503693226867 3327 3867 2890 3422 4038 1860 3062 3754 4295 3644 2543 3751 M15752 GO_HETEROCHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. 3/13 Gene Ontology BP GO:0070828 0.307540526910048 0.331840731220858 3425 3500.09090909091 3423 0.0360834519432321 2373 0.298508687509016 0.342304832626862 1 0.16940648070153 3423 2998 4452 3466 3840 3049 2373 2947 4097 4575 3281 3752 M10410 GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. 62/127 Gene Ontology BP GO:2000058 0.265881414546078 0.288240520382109 1650 3269.63636363636 3424 0.0277075150563321 1649 1.00816583285865 -1.00816583285865 -1 0.645207896721541 1649 4546 3424 4477 4309 1813 2001 2986 4221 4133 2407 3753 M14937 GO_REGULATION_OF_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cilium assembly. 32/66 Gene Ontology BP GO:1902017 0.0839184282471183 0.0949861682962873 3160 3274.90909090909 3424 0.00793650793650794 2227 1.06803092664858 -1.1339414522128 -1 1.29347060123633 3160 3857 3289 4102 3776 2338 3424 2227 3619 3945 2287 3754 M12670 GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 70/262 Gene Ontology BP GO:0038095 0.00906988855243037 0.0121149288115461 1365 2738.09090909091 3425 0.000827954365641992 830 1.1644012597438 -1.14342560399163 -1 2.6438079660624 1362 4475 3425 4134 3890 830 1364 1912 3541 4016 1170 3755 M15269 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html A process in which a protein is transported to, or maintained in, a location within the mitochondrion. 44/92 Gene Ontology BP GO:0070585 0.232850105696956 0.253922063757934 3425 3598.72727272727 3425 0.0238095238095238 2578 0.954545034361392 -0.760501037443428 -1 0.673145584775037 3266 4617 3423 4568 4306 2578 2950 2669 3816 3968 3425 3756 M16841 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 8/24 Gene Ontology BP GO:0060260 0.422542350152828 0.451003248680363 3220 3569.63636363636 3425 0.0534315740522295 2127 0.732213695236796 0.732213695236796 1 0.299960476635819 3216 2933 4624 3425 4011 2127 2770 4523 4183 4635 2819 3757 M16408 GO_REGULATION_OF_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROPTOTIC_PROCESS.html Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. 10/18 Gene Ontology BP GO:0060544 0.0260114987057128 0.033088051641267 3430 3347.27272727273 3426 0.00239311202730093 2630 1.14467114119873 1.24032409483148 1 2.00732023032461 3667 2796 2630 2786 3426 3394 3428 4520 3841 2842 3490 3758 M12729 GO_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. 455/1026 Gene Ontology BP GO:0009894 0.00609110166244781 0.00828868259634971 3340 3232.54545454545 3427 0.000555275604472207 654 1.17523869398955 -1.12136948669198 -1 2.8978998350718 3336 4460 3456 4478 3699 654 2908 3322 3427 4150 1668 3759 M12781 GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 254/577 Gene Ontology BP GO:0009896 0.00375421586263429 0.00523448175682013 2695 3047.09090909091 3427 0.000341876148689734 563 1.14018171581888 -1.08822917471508 -1 3.08106790761701 2694 4404 3427 4382 4093 563 2441 2840 3444 4122 1108 3760 M14993 GO_MEIOTIC_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE_PROCESS.html A process that is part of the meiotic cell cycle. 76/298 Gene Ontology BP GO:1903046 0.0839184282471183 0.0949861682962873 1400 3441.09090909091 3427 0.00793650793650794 1398 1.65295740255914 1.9222522995681 1 2.00186411802348 1398 4418 2597 4472 4575 3084 2971 3427 3556 4078 3276 3761 M10274 GO_NUCLEAR_ENVELOPE_REASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_REASSEMBLY.html The reformation of the nuclear envelope following its breakdown in the context of a normal process. 17/24 Gene Ontology BP GO:0031468 0.00698139196973472 0.00944498830035273 3430 3183.27272727273 3428 0.0006366950334454 1841 1.78544145557752 2.46402599434621 1 4.28257889157536 3428 3663 2748 2578 3260 3982 4201 3629 1841 3459 2227 3762 M12186 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. 13/35 Gene Ontology BP GO:0051770 0.0270940035058091 0.0344367528818702 3005 3495.09090909091 3428 0.00249395885824942 2686 1.00690838759587 -0.504674660524815 -1 1.74503997203907 3003 4498 3016 3503 3428 2994 2686 4636 4030 3747 2905 3763 M11252 GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. 14/35 Gene Ontology BP GO:0010833 0.846676480546328 0.867605142170956 2825 3629.81818181818 3429 0.156734302244151 2521 0.220511848386968 -0.265525065014538 -1 0.0161099485542189 2822 4304 3293 4318 4348 2759 2521 3429 4456 4254 3424 3764 M15788 GO_SNRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_PROCESSING.html Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. 14/23 Gene Ontology BP GO:0016180 0.426176005885577 0.454568158816157 2800 3590.54545454545 3429 0.0492402423365175 2799 0.532941840513054 -0.532941840513054 -1 0.216167077121261 2799 4007 3333 4407 3891 2856 3429 2978 4194 4576 3026 3765 M16038 GO_PEPTIDYL_ARGININE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_METHYLATION.html The addition of a methyl group to an arginine residue in a protein. 8/14 Gene Ontology BP GO:0018216 0.105932691338457 0.119177486281671 3095 3522.72727272727 3429 0.01113496394393 2514 0.214688336272639 -0.208927300111943 -1 0.234943869989024 3091 3414 4498 3429 3650 2514 2561 3470 4233 4588 3302 3766 M10887 GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. 117/261 Gene Ontology BP GO:0032104 6.26407757706472e-07 3.2678777741923e-06 3940 3179.54545454545 3430 5.69461760058295e-08 759 1.03889123985729 -0.921539432693554 -1 6.75122898246588 3937 2299 3216 3956 759 2243 4080 4182 3430 3850 3023 3767 M13873 GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is regionalized in the dorsoventral axis. 5/25 Gene Ontology BP GO:0021904 0.0250930754831049 0.0319460239835634 4575 3210.90909090909 3430 0.00253810101860486 1060 1.7249629795073 -2.53525564949683 -1 3.05610460785555 4573 2375 4150 2170 3430 4206 2475 3975 1060 2990 3916 3768 M15831 GO_PEPTIDYL_ASPARAGINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ASPARAGINE_MODIFICATION.html The modification of peptidyl-asparagine. 18/40 Gene Ontology BP GO:0018196 0.0839184282471183 0.0949861682962873 3430 3473.63636363636 3430 0.00793650793650794 2804 1.18314091437681 -0.85376584796524 -1 1.43287815480481 3430 3497 3124 3646 4188 4324 2912 3408 2804 3553 3324 3769 M13209 GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that modulates the frequency, rate or extent of a response to nutrient levels. 117/261 Gene Ontology BP GO:0032107 6.26407757706472e-07 3.2678777741923e-06 3940 3183.54545454545 3431 5.69461760058295e-08 760 1.03889123985729 -0.921539432693554 -1 6.75122898246588 3938 2300 3217 3957 760 2244 4081 4216 3431 3851 3024 3770 M14472 GO_NUCLEAR_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_IMPORT.html The directed movement of substances into the nucleus. 72/180 Gene Ontology BP GO:0051170 0.0839184282471183 0.0949861682962873 3435 3461.54545454545 3431 0.00793650793650794 2014 1.3403069722977 -1.49880122267684 -1 1.62321902853058 3431 4605 3253 4260 4270 2424 3497 3081 3425 3817 2014 3771 M15695 GO_REGULATION_OF_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_COHESION.html Any process that modulates the frequency, rate or extent of sister chromatid cohesion. 11/21 Gene Ontology BP GO:0007063 0.0839184282471183 0.0949861682962873 4220 3584.81818181818 3431 0.00793650793650794 2512 1.72303005623406 -1.8818988242565 -1 2.086727798523 4217 3154 2512 3396 4461 4605 3431 3182 3460 2944 4071 3772 M16937 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. 114/261 Gene Ontology BP GO:1903322 0.0839184282471183 0.0949861682962873 2580 3293.63636363636 3431 0.00793650793650794 1681 1.03056428371222 -0.941549243041998 -1 1.24809545060636 2576 4530 3431 4512 4135 1681 2528 2904 3634 4055 2244 3773 M10677 GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of dendritic cell differentiation. 18/50 Gene Ontology BP GO:2001198 0.0839184282471183 0.0949861682962873 3415 3531.09090909091 3433 0.00793650793650794 2346 1.85812951867389 -1.74489006154881 -1 2.25034423110937 3412 3943 2346 3433 4301 3150 4225 4488 3341 2437 3766 3774 M15586 GO_PROTEIN_ACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACYLATION.html The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. 94/188 Gene Ontology BP GO:0043543 0.00284914677393102 0.00402942079541936 1725 2828 3433 0.000259349392090404 554 1.18312492663453 -1.11435967796906 -1 3.35637137182912 1721 4412 3433 4570 3704 554 2154 2038 3599 4008 915 3775 M15724 GO_LONG_CHAIN_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_TRANSPORT.html The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 19/73 Gene Ontology BP GO:0015909 0.0014817128053929 0.0021709032992866 3165 3508 3433 0.000134791971779531 1813 1.17314689181525 1.53513761779409 1 3.70134948507031 3163 3316 1813 3308 2990 4622 4604 3947 3486 3906 3433 3776 M10506 GO_ICOSANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. 22/58 Gene Ontology BP GO:0046456 0.0769549780541137 0.0919932963710736 4635 3260.72727272727 3434 0.00725331841031506 1726 1.80244811211977 1.46355869142745 1 2.21259790045405 4631 3487 1726 3153 3583 3434 3771 2631 2872 2301 4279 3777 M16656 GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. 16/39 Gene Ontology BP GO:0014065 1.80673242591923e-05 4.0980257222975e-05 4115 2827.45454545455 3434 1.64249751248686e-06 808 1.50421338994219 -1.34541769715959 -1 7.81802753668898 4113 831 1531 808 1932 4541 3732 4096 1902 3434 4182 3778 M15813 GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of fatty acid derivative. 22/58 Gene Ontology BP GO:1901570 0.0769549780541137 0.0919932963710736 4635 3262.72727272727 3435 0.00725331841031506 1727 1.80244811211977 1.46355869142745 1 2.21259790045405 4632 3488 1727 3154 3584 3435 3772 2637 2873 2308 4280 3779 M13550 GO_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. 334/846 Gene Ontology BP GO:0006325 0.0350833733861032 0.0440129971985078 2595 3440.18181818182 3436 0.00324142417434503 2181 1.28178127209096 -0.935351343030336 -1 2.0596126535793 2593 4582 3436 4586 3461 2181 3007 3627 3365 4158 2846 3780 M13783 GO_VIRAL_LIFE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LIFE_CYCLE.html A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. 184/480 Gene Ontology BP GO:0019058 0.0839184282471183 0.0949861682962873 3400 3325.18181818182 3437 0.00793650793650794 1306 1.32830970877462 -1.12123707335965 -1 1.60868936702789 3396 4408 3437 4271 4187 1306 1938 3544 3293 3971 2826 3781 M14054 GO_VITAMIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORT.html The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 15/42 Gene Ontology BP GO:0051180 0.000541013695741979 0.000854978417062631 4045 2967.36363636364 3437 4.91951622835016e-05 947 1.86101994867342 1.46078649323081 1 6.76379951014885 4044 2277 947 3437 2783 3877 4293 3515 1861 1019 4588 3782 M10252 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS.html The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. 38/67 Gene Ontology BP GO:0097031 0.245592630880585 0.267171177408284 4445 3198.09090909091 3438 0.0252948389937895 1492 0.602778836248141 -0.602778836248141 -1 0.409306245072207 1492 4426 3438 4185 4441 1857 1911 2480 4445 4192 2312 3783 M13411 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. 38/67 Gene Ontology BP GO:0032981 0.245592630880585 0.267171177408284 1495 3211.27272727273 3439 0.0252948389937895 1493 0.602778836248141 -0.602778836248141 -1 0.409306245072207 1493 4427 3439 4186 4442 1858 1912 2400 4446 4408 2313 3784 M15490 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN.html The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. 10/41 Gene Ontology BP GO:0003081 7.90889057486046e-05 0.000146707866316728 4325 3236.09090909091 3439 7.19015900895757e-06 1210 1.42683198172462 -1.22347896612239 -1 6.47965034292008 4322 1210 2448 3439 2379 4513 4025 4621 2182 2838 3620 3785 M15064 GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. 38/67 Gene Ontology BP GO:0010257 0.245592630880585 0.267171177408284 1495 3238.90909090909 3440 0.0252948389937895 1494 0.602778836248141 -0.602778836248141 -1 0.409306245072207 1494 4428 3440 4187 4443 1859 1913 2583 4447 4520 2314 3786 M16013 GO_CELLULAR_COMPONENT_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY.html A cellular process that results in the breakdown of a cellular component. 334/744 Gene Ontology BP GO:0022411 2.56066159730055e-06 8.48013680190188e-06 3990 3095.18181818182 3440 2.32787688886764e-07 1313 1.59038625033036 -1.25628688533793 -1 9.55488327583219 3990 3619 2026 3628 1313 2376 3262 4368 2087 3440 3938 3787 M14908 GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of cellular protein catabolic process. 168/354 Gene Ontology BP GO:1903362 0.00578566166853929 0.00789618669224806 1845 2874.18181818182 3442 0.000527357575053206 712 1.12372083699982 -1.08045525165899 -1 2.79891261241962 1841 4464 3442 4475 4247 712 1474 2286 3477 4139 1059 3788 M16265 GO_RESPONSE_TO_MISFOLDED_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MISFOLDED_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. 7/17 Gene Ontology BP GO:0051788 0.0765897756730953 0.0916038970762961 3390 3666.72727272727 3442 0.00793650793650794 2723 2.38236779657299 -2.38236779657299 -1 2.92967885923213 3387 4349 4538 4282 4278 3191 3515 3442 3328 3301 2723 3789 M12540 GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. 10/22 Gene Ontology BP GO:0031061 0.0839184282471183 0.0949861682962873 2225 3159.72727272727 3444 0.00793650793650794 2165 1.27878511939577 1.27878511939577 1 1.54871106294633 2224 3916 2752 3809 3777 2666 2165 2889 3539 3576 3444 3790 M13224 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. 22/63 Gene Ontology BP GO:1903312 0.558212375945474 0.587039651532239 2515 3417.81818181818 3444 0.0715753000570189 2045 0.259364835292753 -0.278643404058152 -1 0.0710748071643039 2512 4192 3285 3675 4388 2270 2045 3444 4511 4392 2882 3791 M14444 GO_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. 91/217 Gene Ontology BP GO:0035303 0.000220145158023367 0.000373177790690942 3445 3274.09090909091 3444 2.00151991046494e-05 2264 1.51416509244332 -1.07191317457883 -1 6.1489745342645 3520 4026 2264 2725 2610 3755 3442 3766 2440 3444 4023 3792 M14844 GO_STEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 8/19 Gene Ontology BP GO:0016127 6.36479606715183e-05 0.000121163379006912 2885 3256 3445 6.36497837233105e-06 1753 2.63580312933245 2.15764178897204 1 12.2293508494895 2881 3445 4302 2848 2341 4119 4021 4012 2535 1753 3559 3793 M12160 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). 326/904 Gene Ontology BP GO:0006366 2.13010089540796e-05 4.70059812613078e-05 4295 3427.27272727273 3446 1.93647410901273e-06 1984 1.47761382418045 -1.37184047789036 -1 7.5754918882277 4291 4461 3164 4408 1984 2050 4628 3446 2671 3871 2726 3794 M15450 GO_CHOLESTEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 8/19 Gene Ontology BP GO:0006707 6.36479606715183e-05 0.000121163379006912 2885 3266.90909090909 3446 6.36497837233105e-06 1758 2.63580312933245 2.15764178897204 1 12.2293508494895 2882 3446 4408 2849 2342 4120 4022 4013 2536 1758 3560 3795 M11985 GO_SPERM_CAPACITATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_CAPACITATION.html A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. 8/27 Gene Ontology BP GO:0048240 1.37064726583824e-05 3.2222355722972e-05 4540 3335.18181818182 3447 1.37065571994431e-06 1737 1.07851512603978 -1.06897955208911 -1 5.73890129512373 4540 2448 3838 3440 1876 4565 4324 2167 3447 1737 4305 3796 M13854 GO_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_RECOMBINATION.html Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 112/230 Gene Ontology BP GO:0006310 0.866233613718911 0.886471824663193 2025 3610.81818181818 3447 0.167130421041964 2024 0.795890216044363 -0.619762735427788 -1 0.0493411445408708 2024 4365 3447 4576 4111 2812 3153 3308 4375 4165 3383 3797 M12743 GO_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYUBIQUITINATION.html Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. 135/313 Gene Ontology BP GO:0000209 0.00876812281626554 0.0117287220501069 1545 2988.72727272727 3448 0.000800296772569127 727 0.989958875140346 -0.849827777206963 -1 2.26423145787053 1541 4466 3448 4600 4562 727 1765 2645 3575 4152 1395 3798 M11479 GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. 8/22 Gene Ontology BP GO:0051131 0.0765897756730953 0.0916038970762961 3635 3339.90909090909 3449 0.00793650793650794 2246 1.59065273766286 -1.59065273766286 -1 1.95607931452048 3635 3195 3755 2647 3653 3595 3449 4637 2246 3370 2557 3799 M11656 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL.html A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. 60/138 Gene Ontology BP GO:0070646 0.0282785582295312 0.0358637929144259 4390 2961.63636363636 3449 0.00260442967602357 974 0.908367879643438 -0.919782395283949 -1 1.55528706249521 1982 4332 3449 4433 4386 974 1128 1840 4387 4129 1538 3800 M12539 GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. 79/222 Gene Ontology BP GO:0071346 0.0190775477897832 0.0245637976672112 2820 3354.90909090909 3450 0.00174954705296599 1942 1.63131128199029 1.69593735808797 1 3.11071957180964 2818 4327 1942 4169 3385 4230 3921 2194 3450 2456 4012 3801 M10527 GO_RESPONSE_TO_COLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COLD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. 30/78 Gene Ontology BP GO:0009409 8.18140688666135e-06 2.09406131062672e-05 2865 3172.45454545455 3451 7.4376702836455e-07 1697 1.23891336735842 -1.01582153938091 -1 6.86709355070267 2864 3764 2134 3539 1697 3876 3665 3451 3721 2958 3228 3802 M13425 GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM.html Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. 8/41 Gene Ontology BP GO:0030277 0.0765897756730953 0.0916038970762961 2815 3305 3451 0.00793650793650794 1857 3.08758309322936 3.08758309322936 1 3.79690663773805 2814 3983 4074 2381 3627 3652 3451 3863 1857 3392 3261 3803 M13812 GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. 15/36 Gene Ontology BP GO:0002437 0.0185449410393989 0.0239111805737098 4560 3341.63636363636 3451 0.00170028509594425 1680 1.44653756655027 -1.66193908509812 -1 2.77841715128401 4559 3182 1680 3875 3377 4327 3714 2917 3451 2118 3558 3804 M10931 GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 30/61 Gene Ontology BP GO:0043647 0.0839184282471183 0.0949861682962873 4190 3471 3452 0.00793650793650794 2555 1.22214729919699 -1.1875241564793 -1 1.48011805803693 4190 4090 2555 4147 3842 2913 4457 2703 3452 2959 2873 3805 M15919 GO_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION.html The process in which a methyl group is covalently attached to a molecule. 137/308 Gene Ontology BP GO:0032259 0.0239407270543694 0.0305291940987194 1750 2999.09090909091 3452 0.00220048119608041 935 0.968746377994109 -0.901565958920494 -1 1.73892959987421 1746 4323 3452 4609 4531 935 1689 2219 3754 4154 1578 3806 M11099 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. 51/89 Gene Ontology BP GO:0033108 0.0603845668847291 0.0737415949620718 945 2903.27272727273 3455 0.00564623621922925 941 0.677070908234597 -0.677070908234597 -1 0.908172096086959 941 4279 3455 4425 3926 1350 1517 1791 4239 4111 1902 3807 M13391 GO_VITAMIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 6/24 Gene Ontology BP GO:0009110 0.0748986722695979 0.0906555097361166 3455 3551.18181818182 3455 0.00775497421489308 1889 1.5279270672367 -1.5279270672367 -1 1.88712415658149 3455 4569 4066 4485 4499 3546 3120 1889 3426 3137 2871 3808 M16659 GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 24/47 Gene Ontology BP GO:0072528 0.648836162425351 0.677128860899281 2810 3627 3455 0.0907512600905845 2807 0.749274036769661 -0.793694991344058 -1 0.150294966678454 2807 3860 3013 4035 3984 3070 3339 3431 4278 4625 3455 3809 M10281 GO_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGY.html Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 168/374 Gene Ontology BP GO:0010506 1.35439614888745e-05 3.19049280531935e-05 3865 3327.72727272727 3456 1.23127680644619e-06 1850 1.06282134679863 -0.956214410881453 -1 5.66080614249496 3861 3140 3317 4313 1850 2123 3585 3888 3456 3924 3148 3810 M12248 GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. 11/22 Gene Ontology BP GO:0030970 0.553783978755355 0.583572177340243 3320 3655.27272727273 3456 0.0707330979549041 2781 0.8273088280295 -0.8273088280295 -1 0.229236021800436 3316 4169 3191 4310 4118 2899 3113 3456 4531 4324 2781 3811 M13023 GO_VITAMIN_D_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). 3/25 Gene Ontology BP GO:0042359 0.481063017846562 0.509019050105193 3200 3475.72727272727 3456 0.0634920634920635 2383 1.04235288485935 1.04235288485935 1 0.362120006549809 3196 3456 3995 2383 4167 3789 4272 3145 4008 2585 3237 3812 M10934 GO_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLATION.html The modification of histones by addition of methyl groups. 42/94 Gene Ontology BP GO:0016571 0.00829816846788851 0.0111225162229811 1685 2897.72727272727 3457 0.000757239506682655 715 0.667229115535331 -0.667229115535331 -1 1.5443013305508 1682 4424 3457 4597 4584 715 736 2104 4300 4083 1193 3813 M11966 GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 9/24 Gene Ontology BP GO:0045723 0.000679655371344145 0.00105187996305029 4450 3126.09090909091 3457 6.79863330005906e-05 870 1.80834604068424 -1.66091444965491 -1 6.37953687297406 4447 1655 3835 2004 2863 4471 3874 3457 870 2677 4234 3814 M12919 GO_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_PHOSPHORYLATION.html The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 46/99 Gene Ontology BP GO:0006119 0.144108981163825 0.160918229808475 960 2874.54545454545 3458 0.0140469734641158 960 0.715804183018266 -0.715804183018266 -1 0.672760635809279 960 3996 3458 3981 3723 1514 1280 2295 4209 4091 2113 3815 M10356 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. 95/205 Gene Ontology BP GO:1903321 0.32864341779265 0.353788868261366 2730 3517.45454545455 3459 0.0355749607517454 2117 0.893663018184468 -0.996378850001556 -1 0.477719743680138 2729 4533 3459 4437 4536 2117 2793 3337 4171 4124 2456 3816 M11141 GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. 20/52 Gene Ontology BP GO:0050869 0.161385165508919 0.178875942577683 2580 3172.90909090909 3459 0.0158730158730159 1771 1.05487948261571 -1.15916260856189 -1 0.934030777179092 2580 4338 2737 4397 4102 1862 1771 3459 3756 3671 2229 3817 M11462 GO_DETECTION_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_OTHER_ORGANISM.html The series of events in which a stimulus from another organism is received and converted into a molecular signal. 20/63 Gene Ontology BP GO:0098543 0.0839184282471183 0.0949861682962873 3175 3508 3459 0.00793650793650794 2497 1.82162631708836 -1.39321412789437 -1 2.20613588628293 3172 4387 2497 3383 4105 2901 3549 4404 3531 3200 3459 3818 M14660 GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 10/35 Gene Ontology BP GO:0032660 0.050582685214899 0.0623785942769657 3460 3251.72727272727 3459 0.00470768716007779 2080 1.54105897255937 -1.29709455190732 -1 2.19973948348559 3459 3918 2471 2642 3524 4133 3421 3805 2680 2080 3636 3819 M14756 GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. 7/14 Gene Ontology BP GO:0046341 0.00197397126922795 0.00284102560540154 4340 3272.36363636364 3460 0.000197572691766253 994 1.88494716681452 -1.25457269727766 -1 5.68623853254316 4340 2768 4287 2750 3071 3460 4183 3643 994 2397 4103 3820 M15006 GO_REGULATION_OF_TRANSLATIONAL_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_FIDELITY.html Any process that modulates the ability of the translational apparatus to interpret the genetic code. 12/16 Gene Ontology BP GO:0006450 0.597171704712454 0.625332334205357 2560 3480.81818181818 3460 0.0793346141990941 2023 0.567798914744984 -0.567798914744984 -1 0.137139124921596 2558 4202 3338 4305 4080 2436 2023 3460 4328 4514 3045 3821 M10843 GO_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. 17/41 Gene Ontology BP GO:0033233 0.0481624391806877 0.0594729268925354 3330 3166.27272727273 3461 0.00447730033973611 1693 0.973884781335752 -1.10528677969326 -1 1.41404264645407 3328 3601 2917 3757 3703 2173 3544 2925 3727 3461 1693 3822 M13742 GO_MITOTIC_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. 39/105 Gene Ontology BP GO:0007052 0.347309492633648 0.373363735655945 2585 3538.18181818182 3461 0.0380439978658932 2489 2.136198346087 2.136198346087 1 1.08275119937401 2583 4380 3160 4182 4238 3442 3033 2489 3946 4006 3461 3823 M11714 GO_PROTEIN_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLATION.html The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 60/135 Gene Ontology BP GO:0006479 0.00177442983813286 0.00256708193175695 4610 2884.36363636364 3462 0.000161442058061285 652 0.747796127314619 -0.819268230430398 -1 2.29485207202537 1918 4610 3462 4607 4259 652 1169 1954 4168 4093 836 3824 M12929 GO_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BINDING.html Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 64/163 Gene Ontology BP GO:0051101 5.19472908226023e-06 1.44425910951702e-05 3630 3274.45454545455 3462 4.72249213482312e-07 1573 1.44486129766093 -1.08400486559116 -1 8.28478754762398 3627 4152 2883 4050 1573 2191 3794 3191 3462 3804 3292 3825 M12762 GO_MYELOID_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_ACTIVATION.html A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. 60/180 Gene Ontology BP GO:0002274 0.00692835269132253 0.00938126029332473 3620 3568.81818181818 3463 0.000631842591031139 2687 1.31360381937033 1.17612183446258 1 3.1553990248621 3617 3824 2687 3430 3257 4313 2737 4055 3463 3254 4620 3826 M16145 GO_PROTEIN_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALKYLATION.html The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 60/135 Gene Ontology BP GO:0008213 0.00177442983813286 0.00256708193175695 1920 2886.18181818182 3463 0.000161442058061285 653 0.747796127314619 -0.819268230430398 -1 2.29485207202537 1919 4611 3463 4608 4260 653 1170 1964 4169 4094 837 3827 M16703 GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 9/13 Gene Ontology BP GO:0007260 0.0001863485416411 0.000319858143748477 4480 2992.81818181818 3463 1.8636417008615e-05 777 1.86433338584763 -1.66459313000615 -1 7.7188758518497 4477 1650 4607 2005 2590 3633 3758 3463 1397 777 4564 3828 M10606 GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 13/39 Gene Ontology BP GO:0061013 0.101383809396249 0.114225922598104 2895 3491 3464 0.00967104670840436 1950 1.082377024765 -1.082377024765 -1 1.20813494007563 2893 4391 3128 4367 4547 2346 3249 3464 4325 3741 1950 3829 M12046 GO_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). 83/171 Gene Ontology BP GO:0045333 0.0839184282471183 0.0949861682962873 2005 3361.18181818182 3464 0.00793650793650794 2004 1.32556644606094 -0.789937050686721 -1 1.60536705285467 2004 4273 3464 4141 3980 2308 2030 4213 3428 4123 3009 3830 M12311 GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. 17/50 Gene Ontology BP GO:0000060 0.0013710896252952 0.0020171004848687 4290 3374 3464 0.000124722260507038 2533 1.65284205596121 1.25923269908602 1 5.27730254538166 4287 3974 2533 3502 2978 3329 3958 3635 2843 3464 2611 3831 M15153 GO_REGULATION_OF_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_MOVEMENT.html Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. 7/27 Gene Ontology BP GO:0003352 0.587338999668956 0.615717989492654 3145 3638.54545454545 3464 0.0847086824588549 2848 0.538262311048561 -0.538262311048561 -1 0.134295804105191 3144 3647 4362 2887 4345 3151 3334 2848 4315 4527 3464 3832 M16258 GO_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progress through the mitotic cell cycle. 310/683 Gene Ontology BP GO:0007346 0.0839184282471183 0.0949861682962873 3205 3520.18181818182 3466 0.00793650793650794 1912 1.2767660324469 -1.08958196144505 -1 1.5462657844997 3204 4517 3397 4339 4268 1912 2809 4026 3466 4116 2668 3833 M11638 GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. 4/15 Gene Ontology BP GO:0045628 0.00170180462704369 0.0024746253941008 3520 3006.54545454545 3467 0.000170310929599285 1590 1.82954073591338 -1.98057969718709 -1 5.64906027066481 3519 1957 3779 2332 3041 3818 3467 3553 1590 1696 4320 3834 M15194 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 17/29 Gene Ontology BP GO:1902253 0.000168385703130889 0.000290529475896216 4390 3408.72727272727 3468 1.53089629616355e-05 2562 1.50613687973475 -1.49482768321487 -1 6.31035997089068 4390 3717 2678 3089 2562 3503 4282 3652 2738 3468 3417 3835 M11770 GO_POSITIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BINDING.html Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 36/70 Gene Ontology BP GO:0043388 0.000389752693355286 0.000629214796678926 4105 3423.90909090909 3469 3.54383417450817e-05 2521 1.33038052094883 -0.80443724744272 -1 5.04506525701365 4105 3763 2976 3195 2725 2521 3469 4158 3406 3872 3473 3836 M14029 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION.html The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. 48/108 Gene Ontology BP GO:0006369 0.467765104508686 0.495852369916399 2380 3525.36363636364 3469 0.055721059403392 2379 0.811922249906002 -0.811922249906002 -1 0.293013630005582 2379 4615 3469 4270 4466 2574 2821 2639 4393 4106 3047 3837 M12485 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. 59/127 Gene Ontology BP GO:2001243 2.20352283914151e-05 4.8419103370251e-05 3470 3431.09090909091 3470 2.00322264542199e-06 1993 1.38859711743594 -1.30621205792508 -1 7.09795714760614 3470 3995 2771 3283 1993 4493 3653 3312 3207 3718 3847 3838 M16225 GO_EPITHELIAL_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MATURATION.html The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 14/25 Gene Ontology BP GO:0002070 0.00423871965127621 0.0058800045834704 3895 3391.36363636364 3470 0.000386082586358986 1788 1.51170456766336 -1.40849506777584 -1 3.99457786047046 3895 3470 1788 3249 3180 4586 4188 3841 2219 2628 4261 3839 M13628 GO_DNA_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION.html The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. 16/31 Gene Ontology BP GO:0022616 0.955700523223453 0.970754217748085 2940 3666.45454545455 3471 0.246739269687296 2939 0.71112730430769 -0.71112730430769 -1 0.010857633080318 2939 3471 3281 3908 4258 3213 3348 3430 4407 4431 3645 3840 M11859 GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 16/35 Gene Ontology BP GO:0090200 0.0438534805558497 0.0543834696102591 3475 3084.45454545455 3472 0.00406843908192864 745 3.38479625896055 -1.21082335525186 -1 5.07038208886491 3472 3863 2281 4090 3601 4121 3068 1698 745 3422 3568 3841 M15084 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 11/35 Gene Ontology BP GO:1902236 0.0145495192068001 0.0189543820643021 4345 3390 3472 0.00133151288102056 2303 1.09178999789173 -0.711590221723078 -1 2.22752844343305 4345 3472 2723 2526 3345 2303 2769 4304 3855 3660 3988 3842 M15974 GO_MACROMOLECULE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_METHYLATION.html The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. 102/226 Gene Ontology BP GO:0043414 0.00942542540607781 0.0125609214008092 1780 2941.09090909091 3472 0.00086055004426559 739 0.890510999080334 -0.763196569334926 -1 2.00536869438234 1777 4531 3472 4599 4370 739 1620 1854 3947 4147 1296 3843 M11348 GO_RIBOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_ASSEMBLY.html The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. 36/75 Gene Ontology BP GO:0042255 0.131876591129195 0.147614033898952 2055 3069.81818181818 3474 0.0127741991162029 1368 0.64405884791949 -0.64405884791949 -1 0.633923435918807 2054 3905 3474 4190 4060 1475 1368 2821 3992 4263 2166 3844 M14642 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 34/84 Gene Ontology BP GO:0010803 0.0839184282471183 0.0949861682962873 3110 3464.45454545455 3474 0.00793650793650794 2438 1.4285317525764 -1.51088934948142 -1 1.73006641011322 3108 4285 2757 4100 4529 2438 3192 3764 3474 3615 2847 3845 M14015 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. 11/42 Gene Ontology BP GO:0042534 0.00406452251627276 0.0056484819045359 4255 3185.09090909091 3475 0.000370186476690231 1105 1.38014526948367 0.85235932545763 1 3.67546420663054 4252 3838 2445 2450 3475 4214 3683 1105 3064 2932 3578 3846 M16900 GO_QUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving quinone. 20/46 Gene Ontology BP GO:1901661 0.000826071446321795 0.00125793693842968 3255 3475 3475 7.51256171438088e-05 2886 1.11988614674727 -0.640819186398468 -1 3.84769700778346 3255 4036 3058 4148 2886 2933 3553 3500 3475 3923 3458 3847 M16716 GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. 34/88 Gene Ontology BP GO:0009185 0.0839184282471183 0.0949861682962873 4015 3579.27272727273 3476 0.00793650793650794 2985 1.10013565941879 -0.980623419680219 -1 1.33235204273236 4013 3310 2985 3476 4114 3456 4084 3414 3204 3829 3487 3848 M12241 GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS.html The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. 134/275 Gene Ontology BP GO:0090305 0.039228657216523 0.0488700443939673 2295 3216.18181818182 3477 0.00363146613560413 1763 0.963899680296534 -0.923408960569711 -1 1.49691791185343 2291 4361 3477 4614 3486 1763 2756 2554 3564 4134 2378 3849 M10211 GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. 9/14 Gene Ontology BP GO:0008608 0.0765897756730953 0.0916038970762961 2480 3306.63636363636 3478 0.00793650793650794 2476 1.19953682734643 -1.19953682734643 -1 1.47511047613846 2476 3478 3554 3638 4235 3080 2534 3521 3561 3475 2821 3850 M13468 GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION.html The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). 7/22 Gene Ontology BP GO:0042074 0.0214101995208088 0.0274303411631113 4170 3398.36363636364 3478 0.00216193192595924 2387 1.28898531545115 -1.53561774604294 -1 2.38474806535449 4168 2571 4082 2603 3411 3534 3478 3128 4114 2387 3906 3851 M15236 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI.html The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. 46/82 Gene Ontology BP GO:0042147 0.252960934476981 0.274800565928082 2680 3264 3478 0.0261641556300365 1578 0.965776731784587 -0.972893059640993 -1 0.64180473967182 2679 4056 3332 3963 4280 1788 1578 3478 4206 3768 2776 3852 M12963 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. 43/66 Gene Ontology BP GO:0042274 0.0631221653697319 0.0769430857998595 1620 3158.63636363636 3479 0.00590995659390507 1207 0.433323187604659 -0.433323187604659 -1 0.571752168715507 1618 4283 3479 4511 4628 1207 1813 2358 4499 4370 1979 3853 M10940 GO_CELLULAR_RESPONSE_TO_SUPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_SUPEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. 7/21 Gene Ontology BP GO:0071451 0.179049545547445 0.197982148124979 3450 3409.90909090909 3480 0.0195359038502905 1331 0.31570958251703 -0.190841101143881 -1 0.263056707503624 3447 3480 3660 3330 4256 1972 1331 4264 4495 4232 3042 3854 M12319 GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neutrophil migration. 13/50 Gene Ontology BP GO:1902624 2.97991120713269e-05 6.22110060014258e-05 4475 3086.18181818182 3480 2.70904688267929e-06 1489 1.44268594994895 -1.51287603502927 -1 7.18840901847055 4472 2228 1489 3556 2096 4046 4192 3534 3480 1840 3015 3855 M13239 GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. 176/377 Gene Ontology BP GO:1903320 0.0590172428245267 0.0721857372060795 2610 3289.45454545455 3480 0.00551477960059491 1216 0.985167478835469 -1.00456291829371 -1 1.33223864605183 2606 4463 3480 4542 4560 1216 2685 3123 3632 4117 1760 3856 M11451 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. 6/12 Gene Ontology BP GO:0070202 0.0207667438918346 0.0266280010742303 1735 2964.72727272727 3481 0.00209634013050673 918 0.561262134236352 -0.561262134236352 -1 1.04696060054981 1731 3723 3748 3481 3462 918 962 4064 4344 4269 1910 3857 M15152 GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 7/21 Gene Ontology BP GO:0071450 0.179049545547445 0.197982148124979 3450 3501.81818181818 3481 0.0195359038502905 1332 0.31570958251703 -0.190841101143881 -1 0.263056707503624 3448 3481 4361 3331 4257 1973 1332 4272 4496 4526 3043 3858 M12493 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. 14/27 Gene Ontology BP GO:0050687 0.0387112312624628 0.0482772620874603 3065 3323.45454545455 3483 0.0035826965352798 1380 1.36528375537602 -0.844013013498795 -1 2.12883252356454 3980 3603 2724 3063 3483 4286 3787 3061 1380 3241 3950 3859 M13204 GO_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an mRNA molecule. 59/117 Gene Ontology BP GO:0031124 0.440607827471238 0.468884286717616 2150 3425.54545454545 3483 0.0514393031337533 2109 0.637046580184103 -0.637046580184103 -1 0.248230726492061 2150 4547 3483 4540 3944 2109 2525 2832 4453 4389 2709 3860 M13347 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. 19/78 Gene Ontology BP GO:0032732 0.000250157627002127 0.000418401247179711 4375 3382.90909090909 3483 2.27441887688777e-05 2009 1.51397218086784 1.50675699247614 1 6.05909620662907 4374 3211 2009 3192 2637 3838 3816 4016 3483 2560 4076 3861 M15098 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. 5/16 Gene Ontology BP GO:0003198 0.598881260040338 0.626685979348048 3545 3527.72727272727 3483 0.0873015873015873 2367 1.29214926568553 -1.29214926568553 -1 0.310654420210053 3545 3483 4352 3936 4474 3171 2367 3103 4126 3003 3245 3862 M15211 GO_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRITY_CHECKPOINT.html A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. 92/197 Gene Ontology BP GO:0031570 0.0839184282471183 0.0949861682962873 3250 3563.45454545455 3483 0.00793650793650794 2953 1.62549951795704 -1.52234830159072 -1 1.96861038744727 3250 4413 2953 4059 3732 3128 3475 3730 3089 3886 3483 3863 M13244 GO_COVALENT_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COVALENT_CHROMATIN_MODIFICATION.html The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. 184/403 Gene Ontology BP GO:0016569 0.00446812537977075 0.0061908403874293 1840 2897.90909090909 3484 0.000407020534302179 595 0.94460414348241 -0.877238426614363 -1 2.47101833977316 1839 4591 3484 4584 4018 595 1570 2398 3635 4151 1012 3864 M10551 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION.html The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. 68/151 Gene Ontology BP GO:0006353 0.124966916621732 0.140082422470957 1310 3113.27272727273 3485 0.0120624387455714 1306 0.829730987099839 -0.829730987099839 -1 0.839029573743406 1306 4419 3485 4384 4209 1685 1864 2051 4284 4118 2441 3865 M14806 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. 37/110 Gene Ontology BP GO:0008543 0.0839184282471183 0.0949861682962873 3150 3488.81818181818 3485 0.00793650793650794 2587 1.32826715364813 -1.22260836410037 -1 1.60863782930999 3148 3787 2587 3389 3619 3872 3208 4352 3485 3029 3901 3866 M15559 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 27/54 Gene Ontology BP GO:1901030 0.0416911740389493 0.0518404180671777 3430 3301.72727272727 3485 0.0038638965628442 1436 1.74833727784236 -0.842294349395756 -1 2.66206219331795 3429 3485 2718 3670 3495 4103 3058 3205 1436 3865 3855 3867 M12125 GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. 5/10 Gene Ontology BP GO:0031284 1.44123794256861e-07 1.49701739761656e-06 3930 2747.09090909091 3486 1.44123803604112e-08 228 1.55306821086662 -1.17259492833427 -1 10.7163670459972 3928 1132 3853 832 228 4151 4411 3486 3677 1973 2547 3868 M15487 GO_RNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an RNA molecule. 70/144 Gene Ontology BP GO:0031123 0.392117836196907 0.419783978202038 1990 3422.63636363636 3486 0.0442435925325216 1990 0.632191518667075 -0.619695790238928 -1 0.282316161220606 1990 4608 3486 4541 3999 2020 2412 2905 4395 4558 2735 3869 M14270 GO_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_ELONGATION.html The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. 70/123 Gene Ontology BP GO:0006414 0.0752059439693263 0.0910037002474803 445 2928.36363636364 3487 0.00708245566473981 443 0.66607253651586 -0.639470474440899 -1 0.821343515739417 443 4028 3487 4058 3578 1487 1792 2396 4078 4462 2403 3870 M14075 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/23 Gene Ontology BP GO:0051590 2.83652391249051e-05 5.97820268982906e-05 3490 3174.45454545455 3488 2.83656011954653e-06 1954 1.38040838385514 1.38040838385514 1 6.90638555150572 3488 1954 4180 2550 2107 3989 2569 3787 3662 2992 3641 3871 M15078 GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. 7/18 Gene Ontology BP GO:1904152 0.153411530433985 0.170771933782064 3215 3262.27272727273 3488 0.0165161449201866 1839 0.640197721879479 -0.711158932338288 -1 0.582125473300153 3215 3894 4344 3488 3783 1839 1845 2493 4316 4522 2146 3872 M12388 GO_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MEMBRANE.html The process of directing proteins towards a membrane, usually using signals contained within the protein. 100/285 Gene Ontology BP GO:0006612 0.0839184282471183 0.0949861682962873 4065 3421 3489 0.00793650793650794 1596 1.19816692148449 -1.05870845337089 -1 1.45107587102497 3329 4150 3489 4063 4316 1596 2270 4380 3374 4065 2599 3873 M12684 GO_PONS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PONS_DEVELOPMENT.html The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. 6/20 Gene Ontology BP GO:0021548 0.00100803230216861 0.00151025943174213 3490 3415.36363636364 3489 0.000100848985241005 2451 0.959088311892239 -0.622232524136862 -1 3.20502647325388 3489 2451 3949 2598 2946 3645 3223 4418 3958 3129 3763 3874 M10231 GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 3/16 Gene Ontology BP GO:0072216 0.0364554903140747 0.0456480155146302 4415 3178.36363636364 3490 0.003706772530232 1415 2.09960594906527 -2.31589561865601 -1 3.33432398915272 4414 2649 3557 2010 3490 4183 3093 3933 1677 1415 4541 3875 M11131 GO_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. 73/119 Gene Ontology BP GO:0032543 0.0557260720025605 0.0683402409688031 405 2831.81818181818 3490 0.005199072066855 405 0.640157651141057 -0.618046530803603 -1 0.883711930324305 405 3520 3490 4054 3572 1585 1824 2200 3819 4247 2434 3876 M11845 GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 75/171 Gene Ontology BP GO:0035967 0.415320710913563 0.443499094013724 4055 3594.18181818182 3490 0.0476190476190476 2562 0.758656330583093 0.880006664175471 1 0.317341987134785 2845 4052 3443 4052 4513 3490 2562 3099 3953 4130 3397 3877 M12302 GO_LIPOPROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_TRANSPORT.html The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/19 Gene Ontology BP GO:0042953 0.00790316385285675 0.0106237376284927 1965 2832.27272727273 3490 0.000793141234846012 1156 0.831803775070724 0.831803775070724 1 1.94484386455527 1963 3670 3887 3768 4593 1407 1458 1454 4309 3490 1156 3878 M16891 GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 14/55 Gene Ontology BP GO:0090022 0.00728143068223451 0.00983067247967863 4095 3282.54545454545 3491 0.000664149327026429 1958 1.44268594994895 -1.51287603502927 -1 3.43073552462647 4094 3550 1958 3731 3267 3491 4566 3013 3711 2011 2716 3879 M14653 GO_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ORGANELLE.html A process in which a protein is transported to, or maintained in, a location within an organelle. 334/807 Gene Ontology BP GO:0033365 0.0157948439221603 0.0205363932597564 2825 3219.81818181818 3492 0.00144630869622309 845 1.32640767582915 -1.06665282275462 -1 2.65150477253295 2825 4402 3492 4389 4320 845 2438 3592 3264 4144 1707 3880 M13799 GO_PROTEIN_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION.html The process in which one or more ubiquitin groups are added to a protein. 303/718 Gene Ontology BP GO:0016567 0.0053724199995893 0.00737338044874168 2795 3150.45454545455 3493 0.000489598593378719 627 1.04092509232731 -0.934050156614633 -1 2.62937423119864 2792 4462 3493 4610 4054 627 2749 3104 3503 4164 1097 3881 M16321 GO_GLUCOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. 20/52 Gene Ontology BP GO:0006007 0.0568177326509543 0.0695871096540176 4385 3557.81818181818 3493 0.00530367924333902 2671 1.12704090212314 -1.1439785055759 -1 1.54535229370647 4385 3493 2671 3275 3543 3754 4068 3405 3395 3676 3471 3882 M12606 GO_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR.html The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 285/574 Gene Ontology BP GO:0006281 0.0839184282471183 0.0949861682962873 1620 3415.36363636364 3494 0.00793650793650794 1620 0.994675213623771 -0.77284152361589 -1 1.20463086895172 1620 4405 3494 4341 4012 2469 3036 3393 3633 4179 2987 3883 M12994 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. 9/26 Gene Ontology BP GO:0032232 0.556982929045236 0.58636413913249 2075 3408.63636363636 3494 0.0781886606689383 2074 0.916253999095832 0.916253999095832 1 0.251631835018896 2074 3842 3991 3870 4600 3187 2214 3008 4384 3494 2831 3884 M10424 GO_RIBOSOME_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. 195/424 Gene Ontology BP GO:0042254 0.221030510480304 0.241981763772707 1210 3217 3495 0.0224517051300796 1209 0.70273180778219 -0.694390139593031 -1 0.512979747998024 1209 4269 3495 4443 4176 1725 2053 2980 4222 4201 2614 3885 M11779 GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 17/63 Gene Ontology BP GO:0045979 0.0839184282471183 0.0949861682962873 3920 3476.18181818182 3495 0.00793650793650794 2208 1.07732929507633 1.08096222962179 1 1.30473168135868 3918 2918 2208 2304 3945 4501 3636 3376 3495 3462 4475 3886 M14058 GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of ATP metabolic process. 17/63 Gene Ontology BP GO:1903580 0.0839184282471183 0.0949861682962873 3920 3484.45454545455 3496 0.00793650793650794 2209 1.07732929507633 1.08096222962179 1 1.30473168135868 3919 2919 2209 2305 3946 4502 3637 3454 3496 3466 4476 3887 M11044 GO_MALE_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DETERMINATION.html The specification of male sex of an individual organism. 2/17 Gene Ontology BP GO:0030238 0.560513380565936 0.589326002257165 3300 3596 3498 0.0873015873015873 2932 0.427517813087303 -0.797759308535111 -1 0.116300582361631 3300 3134 3674 NA 4266 3509 3487 2932 4111 4240 3307 3888 M13057 GO_OVULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION.html The release of a mature ovum/oocyte from an ovary. 8/28 Gene Ontology BP GO:0030728 0.000402502934591214 0.000647547167466046 4005 3410.81818181818 3498 4.02575857056747e-05 2752 2.48821793095678 2.48821793095678 1 9.39905076613825 3265 2993 4002 3498 2752 3604 3678 2819 4001 3385 3522 3889 M14115 GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 16/23 Gene Ontology BP GO:0014733 0.472618230772105 0.500882548613303 2620 3279.18181818182 3498 0.0565070776824477 1827 0.923067076540063 0.905041560509772 1 0.328331497787085 2618 3581 2734 3375 4200 2525 1827 3498 4249 3837 3627 3890 M11960 GO_GLUTAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. 9/24 Gene Ontology BP GO:0006541 0.183726349396224 0.203056757973498 3065 3526.45454545455 3499 0.0200958932992451 3021 0.842497358307479 -0.933529973650784 -1 0.691021735131818 3063 3559 3833 3805 3727 3499 3317 3021 4100 3486 3381 3891 M14947 GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. 18/50 Gene Ontology BP GO:0045143 0.0425320937686862 0.0528577385888678 2130 3334.81818181818 3499 0.00394339312298345 2128 0.817406431507993 0.888727210494804 1 1.23642999045573 2128 4004 2994 4453 3499 2182 2216 4084 3918 3894 3311 3892 M11174 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. 428/988 Gene Ontology BP GO:0070647 0.0839184282471183 0.0949861682962873 3045 3450.36363636364 3500 0.00793650793650794 1494 1.05805932236619 -0.929325587388433 -1 1.28139417776 3042 4515 3500 4587 4432 1494 3276 3419 3532 4177 1980 3893 M15875 GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE.html Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 7/17 Gene Ontology BP GO:0010984 0.0765897756730953 0.0916038970762961 3500 3387.54545454545 3500 0.00793650793650794 1723 1.11302394685118 1.36957621100135 1 1.36872257797493 3500 1723 4471 2667 3975 4265 4067 3189 3297 2405 3704 3894 M10862 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. 45/87 Gene Ontology BP GO:0006283 0.767435909000828 0.793410137049843 2995 3625.72727272727 3501 0.124183810366289 2589 0.660827756295423 -0.690198913010384 -1 0.0786743024149928 2992 4231 3478 4061 4144 2589 3015 3501 4382 4224 3266 3895 M14212 GO_LIPOPROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_LOCALIZATION.html Any process in which a lipoprotein is transported to, or maintained in, a specific location. 9/19 Gene Ontology BP GO:0044872 0.00790316385285675 0.0106237376284927 1965 2862 3501 0.000793141234846012 1157 0.831803775070724 0.831803775070724 1 1.94484386455527 1964 3671 4206 3769 4594 1408 1459 1443 4310 3501 1157 3896 M11272 GO_RRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. 157/371 Gene Ontology BP GO:0016072 0.237606128851582 0.258786126262701 1465 3296.63636363636 3502 0.0243612613941537 1463 0.68085634741054 -0.678225393227998 -1 0.473493267035741 1463 4322 3502 4517 4451 1761 2089 3195 4223 4178 2562 3897 M11321 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION.html The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. 18/23 Gene Ontology BP GO:0006295 0.00546304000199787 0.00748668675598468 3560 3464.18181818182 3502 0.00049787756112931 2298 0.571368141212304 -0.511279682844146 -1 1.43879095705603 3558 3834 3377 3959 3224 2298 3156 3502 3868 4260 3070 3898 M11490 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE.html The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 223/551 Gene Ontology BP GO:0072594 0.000971985725057798 0.00146238811453122 1445 2792.36363636364 3503 8.84014023205113e-05 395 1.04130251183112 -0.998013331318922 -1 3.49702127742006 1444 4407 3503 4390 4622 395 1248 2079 3603 4155 870 3899 M13511 GO_NEURONAL_ION_CHANNEL_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ION_CHANNEL_CLUSTERING.html The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. 4/29 Gene Ontology BP GO:0045161 0.000361220728470936 0.000585187663046252 4515 3044.09090909091 3503 3.61279458093746e-05 347 2.5773194243646 -2.28071318215885 -1 9.86989034753597 4511 2615 4090 1945 2729 3804 4481 3757 347 1703 3503 3900 M10473 GO_REGULATION_OF_T_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. 5/13 Gene Ontology BP GO:0010819 0.102933093421938 0.115903703858044 3870 3196 3504 0.0108036993125353 1960 1.59324326396141 -1.53561774604294 -1 1.76640576145409 3870 2802 3592 2685 3745 3504 3354 2016 3770 1960 3858 3901 M11964 GO_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PROCESSING.html Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. 477/1051 Gene Ontology BP GO:0006396 0.0839184282471183 0.0949861682962873 2015 3429.09090909091 3504 0.00793650793650794 2012 0.960560659849699 -0.769168509639965 -1 1.16331537082177 2012 4514 3504 4518 4208 2097 2726 3334 3618 4303 2886 3902 M16455 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION.html The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 18/23 Gene Ontology BP GO:0006293 0.00546304000199787 0.00748668675598468 3560 3497.45454545455 3504 0.00049787756112931 2299 0.571368141212304 -0.511279682844146 -1 1.43879095705603 3559 3835 3378 3960 3225 2299 3157 3504 3869 4615 3071 3903 M12754 GO_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. 17/50 Gene Ontology BP GO:0009112 0.0436081976131199 0.0541081938850123 3095 3313.63636363636 3505 0.00404521550700895 2253 1.22740810589808 -0.802801042498866 -1 1.8418452369069 3094 3910 2689 3879 3505 2482 2253 3709 3489 3866 3574 3904 M14919 GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. 9/23 Gene Ontology BP GO:0051497 0.556982929045236 0.58636413913249 2075 3440.54545454545 3506 0.0781886606689383 2075 0.916253999095832 0.916253999095832 1 0.251631835018896 2075 3843 4318 3871 4601 3188 2215 3012 4385 3506 2832 3905 M12423 GO_NCRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_PROCESSING.html Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. 239/510 Gene Ontology BP GO:0034470 0.144222319026996 0.161006065699048 1095 3059.72727272727 3507 0.0140588433414981 1095 0.812134090477796 -0.808149284298886 -1 0.763070148704199 1095 4321 3507 4588 3821 1515 1993 2461 3817 4338 2201 3906 M15726 GO_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 78/292 Gene Ontology BP GO:0006338 1.30772567458586e-05 3.09784199341947e-05 4025 3142.54545454545 3507 1.18884858913042e-06 1470 1.84716001033901 -1.19699492328005 -1 9.86636261162726 4025 3241 1470 3205 1839 3639 4312 3507 1603 3686 4041 3907 M11540 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. 8/23 Gene Ontology BP GO:2000696 0.000958996698233138 0.00144378134562142 4020 3110.72727272727 3508 9.59410803368298e-05 1295 1.75388737020695 -1.58794674083902 -1 5.90166092966173 4017 1295 3765 1758 2936 4352 3822 3508 1883 2520 4362 3908 M16293 GO_UTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. 6/13 Gene Ontology BP GO:0046051 0.401703762267876 0.429649981158661 2405 3387 3509 0.0500699481091425 1920 0.240014028557948 -0.257920698770619 -1 0.104312876803922 2404 3509 4542 3604 3922 2087 1920 3257 4547 4602 2863 3909 M13371 GO_NCRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). 313/678 Gene Ontology BP GO:0034660 0.0839184282471183 0.0949861682962873 940 3033.18181818182 3510 0.00793650793650794 936 0.8956218742786 -0.822046975344617 -1 1.0846692219789 936 4267 3510 4590 4052 1435 1970 2359 3606 4402 2238 3910 M13704 GO_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_LOCALIZATION.html Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. 13/39 Gene Ontology BP GO:0051647 0.0123956456116259 0.0162646431625857 3515 3115 3511 0.00113327667097401 497 3.44337313709794 -0.877741928686536 -1 7.29647436786957 3511 4302 2195 3420 4507 3017 3989 1359 497 3754 3714 3911 M13735 GO_POSITIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPAIR.html Any process that activates or increases the frequency, rate or extent of DNA repair. 27/61 Gene Ontology BP GO:0045739 0.0451688128656711 0.0559250128360829 2570 3177.09090909091 3511 0.00419306821303458 1701 0.812221176627102 -0.620686611611616 -1 1.20501582469856 2566 4033 3025 3971 3511 1701 1710 3781 4170 4001 2479 3912 M15708 GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. 9/27 Gene Ontology BP GO:0039531 0.00777587723104702 0.0104647530387685 1075 2666 3511 0.000780322090745827 856 0.988934251532161 -0.988934251532161 -1 2.31990305477893 1071 3612 4444 3701 4272 950 856 1267 4181 3511 1461 3913 M13539 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. 123/271 Gene Ontology BP GO:0071826 0.424512622230361 0.453002092625963 2575 3503.27272727273 3512 0.0489900233429455 2133 0.688796925031079 -0.688796925031079 -1 0.280607071503458 2571 4600 3512 4388 4519 2133 2437 3239 4364 4171 2602 3914 M14381 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. 273/602 Gene Ontology BP GO:0022613 0.276080493688875 0.298867272603741 1435 3371.18181818182 3513 0.0289433408771547 1434 0.709576962084519 -0.70417635523044 -1 0.44089925202274 1434 4406 3513 4547 4424 1829 2249 3261 4314 4473 2633 3915 M11085 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 268/605 Gene Ontology BP GO:1903829 2.65575886427844e-06 8.67137018765456e-06 3190 3223.72727272727 3514 2.41432915474365e-07 1329 1.41456916064075 1.63095550509895 1 8.48236224712199 3186 3514 2677 2889 1329 4576 3704 3749 2042 3818 3977 3916 M11110 GO_NCRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of a non-coding RNA molecule. 10/22 Gene Ontology BP GO:0043628 0.0376775155900091 0.0470766159538247 3520 3668.81818181818 3516 0.00348533585010756 2867 0.620053864874506 -0.532941840513054 -1 0.974858158907079 3516 3948 3218 4013 3481 2867 3268 4373 3988 4245 3440 3917 M10296 GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that modulates the frequency, rate or extent of protein activation cascade. 12/46 Gene Ontology BP GO:2000257 0.0480737540075127 0.0593958048053137 3525 3353.09090909091 3518 0.00446886838494108 2070 1.50123807597338 1.68506060006949 1 2.18074213097985 3522 2070 2113 3442 3518 4476 4586 2199 3769 3038 4151 3918 M13729 GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. 6/24 Gene Ontology BP GO:0042753 0.00459069446303776 0.00635497745732985 3535 3260.54545454545 3519 0.000460020564192695 1305 1.34578050620402 -1.32846656737846 -1 3.50235081068767 3534 3870 4122 3519 3204 3138 3121 2584 3701 1305 3768 3919 M15293 GO_NUCLEUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. 79/272 Gene Ontology BP GO:0006997 0.0839184282471183 0.0949861682962873 3360 3574.09090909091 3519 0.00793650793650794 2881 1.19235497548075 -1.01029608854062 -1 1.44403713190386 3360 4328 3276 4309 3866 2976 2881 3230 3519 4020 3550 3920 M13366 GO_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_GROWTH.html The increase in size or mass of an entire multicellular organism, as opposed to cell growth. 48/121 Gene Ontology BP GO:0035264 0.0483640106095258 0.0597059561978273 4140 3516.54545454545 3520 0.00449646788185392 2487 1.30240029753817 -1.57518300356573 -1 1.88841462013143 4136 3935 2697 4011 3520 4009 4467 2487 3274 2952 3194 3921 M14323 GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. 20/54 Gene Ontology BP GO:0031663 0.0450942679110378 0.0558476089386366 4585 3575.27272727273 3520 0.00418600082872986 1960 1.73605063754237 -2.09327042199717 -1 2.57685326513125 4581 4129 1960 2694 3510 4041 4171 3317 3520 3205 4200 3922 M15602 GO_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINESIS.html The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. 48/118 Gene Ontology BP GO:0000910 0.0839184282471183 0.0949861682962873 4315 3366.63636363636 3521 0.00793650793650794 1941 1.73708674142705 -0.875220161186279 -1 2.1037515870987 4312 3521 1941 3472 4134 3397 3635 2630 2251 3610 4130 3923 M14249 GO_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOR_SIGNALING.html Any process that modulates the frequency, rate or extent of TOR signaling. 45/108 Gene Ontology BP GO:0032006 0.0396159637579876 0.0493260712599454 3665 3200.18181818182 3523 0.00366798705495936 1116 1.03018383696349 -0.800746395509823 -1 1.59493333079478 3662 3785 3134 3674 3489 1116 3233 3614 3523 3974 1998 3924 M16564 GO_RNA_INTERFERENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_INTERFERENCE.html The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. 4/12 Gene Ontology BP GO:0016246 0.518710981202948 0.547357974028475 3525 3557.72727272727 3524 0.0705188315201855 1963 0.16877481066145 -0.192142930694018 -1 0.0523266430097129 3524 3455 4582 3759 4094 2652 1963 3093 4578 4619 2816 3925 M11243 GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of vacuolar transport. 13/23 Gene Ontology BP GO:1903337 0.179869323985214 0.198841255062702 3380 3480.18181818182 3525 0.0178650026379563 2419 1.05644142230402 -1.02563640966284 -1 0.877902619456562 3380 3525 3044 3233 3718 3875 2419 4172 3979 3166 3771 3926 M16521 GO_MONOAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOAMINE_TRANSPORT.html The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/24 Gene Ontology BP GO:0015844 0.00243326970037036 0.00346554331865632 4190 3673.90909090909 3526 0.000243593817424161 2614 1.32991727577884 -0.521781820512482 -1 3.87594865864326 4187 2614 4574 3345 3105 4369 3273 3925 3526 3009 4486 3927 M12893 GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT.html The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 11/44 Gene Ontology BP GO:0015697 0.0516295639272626 0.0635177703535454 3915 3590.81818181818 3527 0.00480750656006809 2446 0.747810951717757 0.747810951717757 1 1.06047733255695 3915 3186 2446 3485 3527 3761 4092 3281 4069 4365 3372 3928 M13345 GO_REGULATION_OF_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 856/2098 Gene Ontology BP GO:0080134 6.06240560622951e-07 3.23212152206309e-06 3980 3285.90909090909 3529 6.06240726010442e-08 781 1.51428171167786 -1.32548803920729 -1 9.84912331691203 3976 3394 4056 3529 781 2530 4546 4206 2616 2300 4211 3929 M16398 GO_APOPTOTIC_MITOCHONDRIAL_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_MITOCHONDRIAL_CHANGES.html The morphological and physiological alterations undergone by mitochondria during apoptosis. 46/85 Gene Ontology BP GO:0008637 3.31056990527994e-05 6.8108987186546e-05 4275 3510.63636363636 3530 3.00965429448588e-06 2134 1.15113809595197 -1.10150686755247 -1 5.68208327684823 4273 3762 2958 4225 2134 2821 3828 4379 3437 3530 3270 3930 M10563 GO_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that modulates the frequency, rate or extent of cellular senescence. 25/46 Gene Ontology BP GO:2000772 0.00203954306434932 0.00293085683929864 4535 3201.72727272727 3532 0.000185585119189454 1079 1.53551559492433 -0.767973524826272 -1 4.60753124976419 4532 3738 2167 3145 3059 3688 4217 1079 1910 3532 4152 3931 M10224 GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of cell cycle checkpoint. 24/42 Gene Ontology BP GO:1901976 5.91934301143e-05 0.000113767070498123 3215 3512.63636363636 3535 5.38136571262891e-06 2148 1.09682512116885 -1.33336393909728 -1 5.12448739252678 3211 4435 3204 4458 2292 2728 4348 4483 3535 3797 2148 3932 M13607 GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. 12/22 Gene Ontology BP GO:0034315 5.77212241475826e-05 0.000111203171666899 3775 3518.45454545455 3535 5.24752169366878e-06 2285 0.520681624651576 -0.45693999073522 -1 2.43878687022361 3772 2517 3187 3535 2285 4360 2998 2942 4304 4426 4377 3933 M11562 GO_DNA_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEALKYLATION.html The removal of an alkyl group from one or more nucleotides within an DNA molecule. 7/20 Gene Ontology BP GO:0035510 0.432814334041362 0.461542708533313 3030 3463.72727272727 3536 0.055128989439749 2466 0.814608233312206 -0.814608233312206 -1 0.324033529481456 3027 3536 3770 3820 4317 2466 3000 2809 4413 4280 2663 3934 M11777 GO_SYNAPTIC_VESICLE_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_RECYCLING.html The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. 15/39 Gene Ontology BP GO:0036465 0.0100998549744104 0.0133752500416963 4350 3157 3536 0.000922411094468604 604 1.63531043952984 -1.40582975935901 -1 3.62975844065375 4348 3911 2059 2242 3303 4085 4264 3536 604 2115 4260 3935 M14671 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition. 63/135 Gene Ontology BP GO:1902807 8.63356762718441e-05 0.000159133205609437 3635 3240.90909090909 3536 7.84900587010748e-06 1577 1.67020199590953 -1.55019930797746 -1 7.51500567944765 3634 4153 2524 3536 2390 3969 4145 3030 1577 2500 4192 3936 M16641 GO_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOLYSIS.html The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. 558/1543 Gene Ontology BP GO:0006508 4.76423651432679e-07 2.83958281592032e-06 4140 2977.36363636364 3536 4.76423753573481e-08 575 1.62073046186576 -1.26073566463286 -1 10.649447196985 4140 4265 4595 4484 679 575 2939 3637 2110 3536 1791 3937 M10119 GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that stops or reduces the activity of a phosphoprotein phosphatase. 8/18 Gene Ontology BP GO:0032515 0.0598959071968706 0.0731833413460711 4350 3571.63636363636 3537 0.00615743211857711 1816 1.3640787021493 0.629282989930558 1 1.83500747125673 4347 3479 3537 3305 3828 4433 4506 1816 2417 3361 4259 3938 M16590 GO_AZOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AZOLE_TRANSPORT.html The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/15 Gene Ontology BP GO:0045117 0.0913533600629321 0.103250645270739 3540 3664.54545454545 3538 0.00953415847635344 1960 0.82915100755709 -0.82915100755709 -1 0.968579162078812 3452 3538 4587 3537 4590 2646 4221 1960 4252 4620 2907 3939 M11908 GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). 13/31 Gene Ontology BP GO:1901071 0.674505744059742 0.701552457363213 2130 3378.36363636364 3540 0.0970041441984534 2129 0.953608298860734 0.953608298860734 1 0.173898158122551 2129 3866 2644 4279 4086 3316 2166 3166 4225 3745 3540 3940 M13379 GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 6/15 Gene Ontology BP GO:0009113 0.319837159147198 0.344548475619592 3075 3401.09090909091 3540 0.0378090004219855 1639 0.82915100755709 -0.82915100755709 -1 0.45452339578383 3073 3781 4063 3540 4137 2250 1639 2953 4506 4404 3066 3941 M10139 GO_RESPONSE_TO_UV_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_C.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. 9/13 Gene Ontology BP GO:0010225 0.207466590355629 0.227884404783815 3570 3357.36363636364 3541 0.0229838156114046 2291 0.793559382453991 0.931751658462808 1 0.603787849634822 3568 2869 3541 3865 3994 3121 2633 2291 3916 3474 3659 3942 M10244 GO_REGULATION_OF_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULOGENESIS.html Any process that modulates the frequency, rate or extent of vasculogenesis. 5/21 Gene Ontology BP GO:2001212 0.669873307935569 0.696890380628467 2700 3568.54545454545 3541 0.10490719942138 2700 0.574826465865324 0.526405613006976 1 0.106795382239791 2700 3541 3559 3931 4009 3146 3425 3073 4362 4191 3317 3943 M14004 GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. 52/125 Gene Ontology BP GO:0060333 0.0556738202862269 0.0682942001556014 3735 3502.90909090909 3541 0.00519406786136536 2454 1.68538363431163 1.74030200506657 1 2.3271915236714 3734 3783 2454 3318 3541 4427 4261 2458 3100 2880 4576 3944 M15932 GO_RNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 148/362 Gene Ontology BP GO:0006401 0.103569506047587 0.11654707139577 2140 3287.36363636364 3541 0.00989026816938103 1367 0.958173167609244 -0.757319774561274 -1 1.0595832991343 2137 4596 3517 4340 4537 1367 1894 3541 3870 4168 2194 3945 M10151 GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION.html The acetylation of the N-terminal amino acid of proteins. 6/15 Gene Ontology BP GO:0006474 0.581103099000311 0.609455994727455 3155 3541.45454545455 3544 0.0833348622502881 2179 0.177716995403996 -0.19213723301801 -1 0.0452736825356884 3152 4175 3544 4167 4410 2354 2179 3455 4430 4187 2903 3946 M12852 GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 47/96 Gene Ontology BP GO:0070301 0.00462744714046379 0.00640013019754942 3980 3425.09090909091 3544 0.000421564472955561 2374 1.2540011872654 -1.18456126866359 -1 3.2589303050033 3979 2496 2374 2528 3189 3840 4007 3719 3361 3544 4639 3947 M10769 GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. 74/160 Gene Ontology BP GO:0042787 0.0839184282471183 0.0949861682962873 2905 3550.54545454545 3545 0.00793650793650794 2868 1.62664578379894 -1.08735878012722 -1 1.9699986085731 2904 4473 3135 4462 3858 3545 2868 2933 2967 3988 3923 3948 M15865 GO_GERM_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. 110/412 Gene Ontology BP GO:0007281 0.00145363548526895 0.0021317844466531 3075 3537.63636363636 3545 0.000132236077704445 2151 1.26506053983382 -1.32488057690928 -1 4.00317757062118 4425 4178 3074 3329 2986 4356 3545 2151 3071 3852 3947 3949 M12790 GO_PROSTAGLANDIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. 13/44 Gene Ontology BP GO:0006693 0.0748320846467152 0.0905985316857102 3185 3242.72727272727 3546 0.00704597154322299 1862 1.76665821405798 -1.76665821405798 -1 2.18254979060387 3183 4249 2415 4223 3797 2131 3546 1862 4014 3751 2499 3950 M13282 GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition. 95/212 Gene Ontology BP GO:1902806 1.10254462506372e-05 2.68405103592161e-05 3550 3494.18181818182 3546 1.00231831870743e-06 1783 1.39818439938366 -1.32451280412441 -1 7.57135408867507 3546 4469 2758 4171 1783 4168 3959 3396 2601 3163 4422 3951 M15959 GO_PROSTANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. 13/44 Gene Ontology BP GO:0006692 0.0619001672007659 0.0754733393679507 3185 3238.72727272727 3547 0.00579215171322991 1799 1.76665821405798 -1.76665821405798 -1 2.34856769069328 3184 4250 2416 4224 3798 2132 3547 1799 4015 3761 2500 3952 M14871 GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. 22/42 Gene Ontology BP GO:0045839 0.0839184282471183 0.0949861682962873 2150 3355.81818181818 3548 0.00793650793650794 2146 1.62211221462581 2.02682338667334 1 1.96450808772576 2146 4189 2378 3548 4405 3656 4338 2450 2310 3955 3539 3953 M16077 GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 386/855 Gene Ontology BP GO:1903827 1.43854292008089e-06 5.69407909457423e-06 3550 3178.72727272727 3548 1.30776714610975e-07 1080 1.3818435980709 -1.15335289366398 -1 8.58513902600837 3548 2882 2875 2739 1080 3776 3769 3822 2239 3796 4440 3954 M16799 GO_RESPONSE_TO_LEPTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEPTIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. 11/27 Gene Ontology BP GO:0044321 0.000763310247261157 0.00117042585139814 4610 3411.09090909091 3548 6.94159284991648e-05 2234 2.48821793095678 2.48821793095678 1 8.6413074155398 4606 2234 2474 2459 2871 3548 3982 4063 3315 3664 4306 3955 M11818 GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrate derivative. 518/1241 Gene Ontology BP GO:1901135 4.11148249753907e-07 2.61980478260637e-06 4445 3081.27272727273 3551 4.11148325823225e-08 607 1.4074439720467 -1.14606419373385 -1 9.30632139030037 4441 1778 3812 3551 607 2444 3987 4433 2315 2657 3869 3956 M12505 GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of T cell tolerance induction. 18/53 Gene Ontology BP GO:0002664 0.0839184282471183 0.0949861682962873 3775 3288.90909090909 3551 0.00793650793650794 1926 2.28482816520192 -2.51404474278763 -1 2.7671109826088 3771 3773 1926 2930 4010 3207 3841 3551 2910 2441 3818 3957 M15860 GO_REGULATION_OF_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PERMEABILITY.html Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. 56/113 Gene Ontology BP GO:0090559 0.0839184282471183 0.0949861682962873 3200 3462.45454545455 3551 0.00793650793650794 2325 1.51508444454655 -0.870215693451299 -1 1.8348887568136 3197 4375 2997 4257 3695 3955 3135 2325 2800 3800 3551 3958 M16613 GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. 10/21 Gene Ontology BP GO:0034616 0.00364492285016248 0.00508973738144494 4570 3445.45454545455 3552 0.000331906885555548 2324 1.07414391445568 -0.900174379190482 -1 2.91811276724678 4570 2324 2330 2589 3157 3957 4230 3977 3552 2845 4369 3959 M11073 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. 8/18 Gene Ontology BP GO:0002204 0.187834590900005 0.207202662282899 3555 3411.72727272727 3553 0.0205901919100438 2246 0.569944343140344 -0.623400820683481 -1 0.461544932345771 3553 2520 3684 3403 4131 2860 3589 2246 4061 4242 3240 3960 M14041 GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. 13/47 Gene Ontology BP GO:1903020 0.557443745451391 0.58636413913249 3155 3623.63636363636 3553 0.0714285714285714 2029 1.27570470293874 -1.00601323991843 -1 0.350348833576805 3154 4497 2029 4216 4383 3929 3327 3519 4073 3180 3553 3961 M13180 GO_POSITIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_T_CELL_SELECTION.html The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. 11/30 Gene Ontology BP GO:0043368 0.00945136797260565 0.0125846577277912 4160 3635 3554 0.000862928879455405 2601 0.941713452414714 -0.765950597399034 -1 2.1197584794092 4157 2601 2844 3132 3293 4537 4496 3554 3080 3654 4637 3962 M13836 GO_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOTYPE_SWITCHING.html The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 8/18 Gene Ontology BP GO:0045190 0.131583329808068 0.14735682592833 3555 3459.72727272727 3554 0.0140093078871013 2108 0.569944343140344 -0.623400820683481 -1 0.561486425373021 3554 2521 4142 3404 4132 2861 3590 2108 4062 4442 3241 3963 M14018 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE.html The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. 8/18 Gene Ontology BP GO:0002208 0.118476638628063 0.132935484086539 3555 3459.81818181818 3555 0.012531199923808 2064 0.569944343140344 -0.623400820683481 -1 0.591686151780909 3555 2522 4171 3405 4133 2862 3591 2064 4063 4450 3242 3964 M14177 GO_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 54/179 Gene Ontology BP GO:0070542 0.00127576547789364 0.00188762878070752 4100 3407.36363636364 3555 0.000116045989731318 1411 1.43784583326014 1.51910427771418 1 4.63992188098536 4098 3276 1411 2727 2963 3713 3564 4129 3540 3555 4505 3965 M13840 GO_REGULATION_OF_EXOSOMAL_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOSOMAL_SECRETION.html Any process that modulates the frequency, rate or extent of exosomal secretion. 11/20 Gene Ontology BP GO:1903541 0.203857239168853 0.224291270488385 3000 3243 3556 0.0205118700315828 1525 0.452774481033226 -0.428272378040147 -1 0.348199530220317 3000 3556 3125 4015 3731 1843 1525 3738 4408 4443 2289 3966 M11875 GO_MEMBRANE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DOCKING.html The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. 33/78 Gene Ontology BP GO:0022406 0.00827086912006663 0.0110891265736267 3545 3640.36363636364 3557 0.000754738907713382 2991 1.29076866461845 1.53179379277877 1 2.98948127496036 3542 3734 2991 3819 3277 4480 4378 3062 3455 3557 3749 3967 M11434 GO_RETINOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. 10/44 Gene Ontology BP GO:0042572 0.0839184282471183 0.0949861682962873 3710 3443.45454545455 3558 0.00793650793650794 2056 1.36394995051871 -1.8033159968074 -1 1.65185259732781 3710 3380 2056 3921 3665 4075 2835 3558 3390 2810 4478 3968 M12321 GO_REGULATION_OF_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. 10/20 Gene Ontology BP GO:0090231 0.0230917599938072 0.0294951971530253 3560 3432.45454545455 3558 0.00212161450643347 2323 0.955759528252118 -1.07086205498801 -1 1.73256020407061 3697 2323 2854 3251 3408 3558 4429 4308 3560 3574 2795 3969 M16511 GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. 448/916 Gene Ontology BP GO:0006974 0.0839184282471183 0.0949861682962873 2870 3680.81818181818 3558 0.00793650793650794 2658 1.18345538677463 -1.0199498688704 -1 1.43325900644514 2868 4581 3491 4482 4625 2658 3610 3330 3558 4176 3110 3970 M16642 GO_SYNAPSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSIS.html The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. 13/41 Gene Ontology BP GO:0007129 0.0646169770414541 0.0786825660643774 1835 3083.27272727273 3562 0.00605425174183006 1410 0.892464331775903 0.888727210494804 1 1.16730730926493 1833 4006 2966 4449 3562 1547 1410 4046 3866 3762 2469 3971 M16046 GO_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORYLATION.html The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. 586/1444 Gene Ontology BP GO:0016310 1.63704288952025e-07 1.61692190219132e-06 4285 3246.72727272727 3563 1.63704301011619e-08 262 1.27422153611072 -1.15686492130387 -1 8.74177941346032 4282 3167 4501 3664 262 1917 4193 4303 2997 3563 2865 3972 M14989 GO_LYTIC_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. 40/73 Gene Ontology BP GO:0080171 0.0024609427788893 0.00350280727234305 4145 3605.81818181818 3565 0.00022397272125314 2780 0.952324478838644 -0.851985248387566 -1 2.77024090529514 4142 2780 3131 4344 3087 3902 3994 3494 3565 3790 3435 3973 M13081 GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). 20/42 Gene Ontology BP GO:0072350 0.43347192797994 0.46203171754152 2400 3427.27272727273 3566 0.0503455996350634 2226 0.775052495160171 -0.775052495160171 -1 0.307876782151155 2397 3941 3313 3976 3893 2226 2705 3566 4509 4380 2794 3974 M16410 GO_LYSOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. 40/73 Gene Ontology BP GO:0007040 0.0024609427788893 0.00350280727234305 4145 3606.81818181818 3566 0.00022397272125314 2781 0.952324478838644 -0.851985248387566 -1 2.77024090529514 4143 2781 3132 4345 3088 3903 3995 3495 3566 3791 3436 3975 M14685 GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. 206/456 Gene Ontology BP GO:0034248 0.0301506418937321 0.0381442589407625 4035 3680.63636363636 3569 0.0027792688855086 2458 1.5143839970556 -1.16282559192005 -1 2.54486558056391 4033 4588 3380 4269 3439 2458 3562 4479 2706 4004 3569 3976 M11748 GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. 10/22 Gene Ontology BP GO:0006206 0.0839184282471183 0.0949861682962873 4505 3614.54545454545 3570 0.00793650793650794 2545 1.60658457341319 -0.711939850730658 -1 1.94570285182172 4503 3293 2545 2997 3879 3809 3272 4642 2788 3570 4462 3977 M12032 GO_NEGATIVE_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_AGING.html Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 14/27 Gene Ontology BP GO:0090344 0.000338472031107002 0.000551412505413969 4110 3007.18181818182 3570 3.07749196873249e-05 374 3.29050979313023 -1.02225042359124 -1 12.7017065353437 4108 3633 2218 3281 3570 4415 3835 628 374 3240 3777 3978 M16318 GO_MITOTIC_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. 8/13 Gene Ontology BP GO:0007064 0.0193594714729838 0.0249060753807326 4155 3515.63636363636 3570 0.00195302239334253 1505 1.8818988242565 -1.8818988242565 -1 3.57516312860131 3173 4209 4548 4155 4414 3400 4153 1505 3570 3408 2137 3979 M16751 GO_HISTONE_H3_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_DEACETYLATION.html The modification of histone H3 by the removal of one or more acetyl groups. 15/23 Gene Ontology BP GO:0070932 0.00538929358168987 0.00739216841943459 4205 3593.36363636364 3573 0.000491140097794455 2727 1.02182856718252 -1.03851930370201 -1 2.57979859455241 4205 2727 2942 3469 3221 3737 4520 3803 3516 3814 3573 3980 M10996 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. 20/51 Gene Ontology BP GO:1900077 0.161385165508919 0.178875942577683 2850 3379.90909090909 3577 0.0158730158730159 2057 1.33993443869772 1.17977312407538 1 1.18642982933862 2850 3577 2057 3650 4407 3946 2760 4342 3706 3198 2686 3981 M13973 GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 17/45 Gene Ontology BP GO:0061036 0.000823606765185209 0.00125459521350227 4325 3336 3578 7.49013870762418e-05 1808 1.48689085167932 1.70268674773845 1 5.1106846055655 4325 2354 2380 1808 2885 4398 3578 4542 3653 2328 4445 3982 M10405 GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. 9/30 Gene Ontology BP GO:0001516 0.0615198506186707 0.0750293318682659 3690 3550.09090909091 3579 0.00632924288507465 1819 1.76665821405798 -1.76665821405798 -1 2.35393049936782 3689 4635 3579 4551 4304 2781 3177 1819 3910 3477 3129 3983 M10425 GO_B_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 16/28 Gene Ontology BP GO:0001782 0.0839184282471183 0.0949861682962873 4445 3449.63636363636 3579 0.00793650793650794 2046 1.66368949602925 -1.0924317523075 -1 2.01486155573381 4444 3579 2046 3043 4351 3643 2433 4469 2854 2848 4236 3984 M11225 GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. 202/480 Gene Ontology BP GO:1903651 1.41023334626239e-06 5.63002014333301e-06 3580 3353.36363636364 3579 1.2820311365856e-07 1071 1.47327022188136 -1.27527600760376 -1 9.16173128718309 3579 4079 2620 4254 1071 4147 3669 2788 2587 3540 4553 3985 M15478 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY.html The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 87/229 Gene Ontology BP GO:0000184 0.0839184282471183 0.0949861682962873 3145 3473.81818181818 3579 0.00793650793650794 1882 1.22304493383014 -0.554639038486505 -1 1.48120516655527 3143 4371 3516 3793 4343 1882 2113 4356 3579 4156 2960 3986 M12551 GO_VESICLE_CYTOSKELETAL_TRAFFICKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_CYTOSKELETAL_TRAFFICKING.html The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. 30/56 Gene Ontology BP GO:0099518 1.01005082179626e-05 2.4945031731915e-05 4350 3304 3580 9.18232235555357e-07 1760 1.08739160017948 -1.23003208389213 -1 5.92934104797384 4346 2838 3042 3580 1760 3900 3432 1818 3907 3912 3809 3987 M13842 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. 16/25 Gene Ontology BP GO:0090083 0.0839184282471183 0.0949861682962873 2880 3436.09090909091 3580 0.00793650793650794 2376 2.10328282137124 1.96374033377036 1 2.54724481161295 2879 3580 2376 2646 4243 3996 4530 3783 2595 3429 3740 3988 M14440 GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. 6/14 Gene Ontology BP GO:0006851 0.000257873786558573 0.000429758790736343 4115 3326.81818181818 3580 2.57903715947165e-05 606 1.82123018170123 -1.82123018170123 -1 7.26368435339114 4115 4046 4237 4077 3580 3512 2239 606 3684 3148 3351 3989 M15352 GO_TROPHECTODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHECTODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. 6/14 Gene Ontology BP GO:0001829 0.00342204599971281 0.00478715262930599 3580 3502.63636363636 3580 0.000342732712854891 1521 0.736356508329747 0.689959258716076 1 2.02366858418129 3580 1521 4393 2863 3166 4250 2594 4481 3225 4546 3910 3990 M10286 GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-4 production. 24/68 Gene Ontology BP GO:0032673 0.0762455268065803 0.0916038970762961 3980 3188.09090909091 3582 0.00718397682724477 1483 1.74979542723492 -1.88876695224312 -1 2.15178261505494 3978 3467 1604 2914 3582 3919 4233 3591 2690 1483 3608 3991 M13928 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 10/28 Gene Ontology BP GO:0010592 0.00193593989868084 0.00278974827733555 4210 3571.27272727273 3584 0.000176149597691078 2756 1.33277390594789 -1.69379145427173 -1 4.03300959105065 4207 3019 2756 2791 3048 4310 3692 3995 3542 3584 4340 3992 M12553 GO_EPITHELIAL_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. 21/60 Gene Ontology BP GO:0003351 0.077081198843341 0.0921204649239723 4125 3435.90909090909 3585 0.00726566027445804 1904 1.07010466665938 0.724924351080236 1 1.31284739260359 4123 3861 2840 3432 3585 3741 4383 1904 3139 3713 3074 3993 M10132 GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION.html Any process that set the alignment of spindle relative to other cellular structures. 18/33 Gene Ontology BP GO:0051294 0.0839184282471183 0.0949861682962873 3575 3516.63636363636 3586 0.00793650793650794 2612 1.62637748762871 1.66598372231811 1 1.9696736800985 3571 3798 2612 3156 3651 4343 3586 3615 2917 3014 4420 3994 M15649 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING.html The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. 15/29 Gene Ontology BP GO:0000717 0.226027646880053 0.247394239619068 3590 3727 3586 0.0230234680735542 2375 0.353288843975212 -0.353288843975212 -1 0.253872121488122 3586 4251 3372 4421 3757 2375 3522 3578 4573 4569 2993 3995 M12251 GO_POLYAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. 8/17 Gene Ontology BP GO:0006595 9.34596591802956e-06 2.3342291424105e-05 3600 3135.90909090909 3587 9.34600522444775e-07 1762 0.896697013562856 -0.878254474235868 -1 4.92015487783441 3600 1912 3878 2699 1762 2996 2079 3920 3587 4326 3736 3996 M10852 GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT.html The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. 7/16 Gene Ontology BP GO:0099514 0.171018102736782 0.189281776163738 2245 3186.18181818182 3588 0.0185809025217076 2153 0.894470931721076 -0.894470931721076 -1 0.765978035033122 2245 3815 3649 3588 3752 2153 2766 2204 4135 4223 2518 3997 M12195 GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. 13/31 Gene Ontology BP GO:0070193 0.138498839142411 0.15480262641748 1505 3122.54545454545 3588 0.0134612017002255 1451 0.892464331775903 0.888727210494804 1 0.856587977218967 1503 4442 2934 4398 4190 1500 1451 3588 4207 3748 2387 3998 M11261 GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT.html The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. 7/16 Gene Ontology BP GO:0048490 0.186050664446302 0.205430020219781 2250 3199.18181818182 3589 0.0203752762698957 2154 0.894470931721076 -0.894470931721076 -1 0.728303637621756 2246 3816 3718 3589 3753 2154 2767 2237 4136 4256 2519 3999 M11922 GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. 7/16 Gene Ontology BP GO:0099517 0.184393820427341 0.203697479953401 2250 3212.63636363636 3590 0.0201760500457599 2155 0.894470931721076 -0.894470931721076 -1 0.732201135620739 2247 3817 3823 3590 3754 2155 2768 2232 4137 4296 2520 4000 M15427 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 10/30 Gene Ontology BP GO:0071354 0.298735036746822 0.322639398840543 4255 3458.72727272727 3590 0.0317460317460317 2442 1.67850177463967 1.67850177463967 1 0.976855985055019 4255 2442 2560 3365 4197 3200 3812 2886 3864 3590 3875 4001 M15436 GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. 9/22 Gene Ontology BP GO:0044320 0.00142602105551153 0.00209260927962706 3590 3496.81818181818 3590 0.000142693697405136 2170 2.48821793095678 2.48821793095678 1 7.89750100792925 3590 2170 4404 2529 3011 4429 3884 3468 3671 3510 3799 4002 M11100 GO_HYALURONAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 8/19 Gene Ontology BP GO:0030214 0.0367985180606803 0.0460402908530689 3835 3290.54545454545 3591 0.00374224686275921 1676 1.72240989679249 -1.22073854704435 -1 2.72772702095631 3831 3099 3689 3297 3675 3591 2715 1676 3712 2516 4395 4003 M15519 GO_CELLULAR_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. 10/17 Gene Ontology BP GO:0006878 0.415320710913563 0.443499094013724 3695 3519.54545454545 3592 0.0476190476190476 2645 1.40912447484393 -0.789261135824363 -1 0.589430861979578 3693 3125 2645 2717 4528 4380 3363 2846 3923 3592 3903 4004 M11357 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. 17/69 Gene Ontology BP GO:0002716 0.0839184282471183 0.0949861682962873 3760 3334 3593 0.00793650793650794 2014 2.12514392694591 2.28835408326222 1 2.5737203877694 3756 3882 2014 2923 4311 4549 3593 2380 2770 2321 4175 4005 M15420 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. 7/16 Gene Ontology BP GO:1903203 0.074257671244858 0.0899500045890623 4065 3659 3593 0.00768624316571939 2884 1.3270471019693 -0.521781820512482 -1 1.64435349573334 4062 3534 4402 2884 3593 4453 4269 3130 2931 3297 3694 4006 M15795 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY.html Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. 17/69 Gene Ontology BP GO:0045953 0.0839184282471183 0.0949861682962873 3760 3335.18181818182 3594 0.00793650793650794 2015 2.12514392694591 2.28835408326222 1 2.5737203877694 3757 3883 2015 2924 4312 4550 3594 2372 2771 2333 4176 4007 M12374 GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. 7/37 Gene Ontology BP GO:0033081 0.0806317552220015 0.0949861682962873 3035 3310 3595 0.00837161475285954 1361 0.871835998034566 -0.871835998034566 -1 1.0558625920582 3034 3447 3899 3595 3605 2221 1361 3707 4379 4334 2828 4008 M12392 GO_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that modulates the frequency, rate or extent of thymocyte aggregation. 7/37 Gene Ontology BP GO:2000398 0.0806317552220015 0.0949861682962873 3035 3311.27272727273 3596 0.00837161475285954 1362 0.871835998034566 -0.871835998034566 -1 1.0558625920582 3035 3448 3902 3596 3606 2222 1362 3708 4380 4336 2829 4009 M16453 GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the N-terminal amino acid residue in a protein. 10/27 Gene Ontology BP GO:0031365 0.86178840372999 0.88211718662221 3600 3779.45454545455 3596 0.164651532392926 2936 0.191898140740654 -0.197849310426776 -1 0.0123816034127463 3596 4307 3335 4175 4643 2972 2936 3200 4336 4614 3460 4010 M10485 GO_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLERANCE_INDUCTION.html A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. 5/14 Gene Ontology BP GO:0002507 0.147859119791321 0.16482830568814 4250 3364 3597 0.0158730158730159 1827 1.06246282758877 1.10176164072011 1 0.985451447156443 4248 1827 3597 1970 3711 4574 3345 2483 3666 2967 4616 4011 M10662 GO_IRON_COORDINATION_ENTITY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_COORDINATION_ENTITY_TRANSPORT.html The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 4/13 Gene Ontology BP GO:1901678 0.425289375747468 0.453726693840877 3255 3529.36363636364 3597 0.0538828332680788 2628 0.177198483972805 -0.210710950269901 -1 0.0720414455980284 3252 3755 3616 3597 4620 2871 2747 2628 4164 4213 3360 4012 M11499 GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that activates or increases the frequency, rate or extent of membrane depolarization. 8/17 Gene Ontology BP GO:1904181 0.0760151641212365 0.0916038970762961 4595 3399.90909090909 3597 0.0078747919663236 1865 2.55483564357547 -3.19379569295086 -1 3.14176856932324 4593 3413 3759 3695 3597 4570 2862 2242 1865 2519 4284 4013 M12930 GO_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 16/81 Gene Ontology BP GO:0002377 1.77779290427486e-05 4.03632882862992e-05 4180 3443.45454545455 3597 1.61618842778445e-06 1854 0.679979588532273 -0.654804229091331 -1 3.53944488983067 4176 1854 2947 3510 1926 3278 4091 4528 3597 4368 3603 4014 M10523 GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. 8/19 Gene Ontology BP GO:0048715 0.0764258970246507 0.0916038970762961 3600 3527.36363636364 3598 0.00791890308033242 2857 1.29214926568553 -1.29214926568553 -1 1.5889992127323 3670 3844 3598 3382 3599 2916 4181 2857 3939 3363 3452 4015 M14439 GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 7/29 Gene Ontology BP GO:0006144 0.0832662312806896 0.0949861682962873 2320 3005.54545454545 3598 0.00865613578856211 1075 0.84823163838297 -0.84823163838297 -1 1.02727579348822 2320 3673 4236 3598 3747 1401 1075 1980 4339 4480 2212 4016 M14470 GO_LYMPH_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. 5/17 Gene Ontology BP GO:0036303 0.0765897756730953 0.0916038970762961 3600 3345.90909090909 3599 0.00793650793650794 1981 1.43618151943232 -1.85836770731583 -1 1.7661206847739 3599 3820 4241 3411 3685 3725 4570 3157 2237 1981 2379 4017 M12368 GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. 26/79 Gene Ontology BP GO:1903018 0.459748310575863 0.48813432563543 3015 3384.45454545455 3601 0.0544368089858219 2239 1.17142698461571 -1.07793468927987 -1 0.43221001286117 3012 4002 2239 3892 4449 2263 3319 3728 4066 3601 2658 4018 M15338 GO_GOLGI_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LOCALIZATION.html Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. 9/19 Gene Ontology BP GO:0051645 0.0717555738374302 0.0871465156492776 2465 3438 3602 0.00741836613893106 1848 0.877741928686536 -0.877741928686536 -1 1.10191399111858 2463 4068 4391 3602 4420 1933 3136 3435 3977 4545 1848 4019 M16846 GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY.html Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. 7/22 Gene Ontology BP GO:0051482 4.03415227260814e-05 8.10847142931584e-05 4410 3291.36363636364 3602 4.03422550920982e-06 1873 2.11647589881538 -2.39328218936781 -1 10.2571643418106 4408 1873 4625 1924 2211 3602 4121 3040 3650 2412 4339 4020 M13579 GO_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR.html A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). 66/133 Gene Ontology BP GO:0006289 0.0839184282471183 0.0949861682962873 3460 3693.63636363636 3604 0.00793650793650794 2547 1.21583830156477 -0.581004810137597 -1 1.47247734898348 3460 4276 3430 4435 4045 2990 3391 4314 2547 4138 3604 4021 M14401 GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. 26/71 Gene Ontology BP GO:0042304 1.39486013525481e-06 5.59269050776173e-06 4275 3108.72727272727 3605 1.2680554723955e-07 1066 1.3402082290268 1.30810974425217 1 8.33885396370528 4275 2061 2395 2105 1066 3608 4211 3858 2779 3605 4233 4022 M16236 GO_SNRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. 42/91 Gene Ontology BP GO:0016073 0.949584863446652 0.964947914973519 3610 3947.72727272727 3608 0.237831500700094 3286 0.564026180736326 0.579568350847961 1 0.0103521370298684 3608 4552 3460 4613 4527 3286 3302 3601 4451 4595 3430 4023 M10125 GO_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION.html A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. 530/1244 Gene Ontology BP GO:0051276 0.0765897756730953 0.0916038970762961 3540 3834.63636363636 3609 0.00793650793650794 3065 1.16244814860306 -0.902195211074488 -1 1.4295012379004 3088 4577 3539 4591 4336 3065 3538 4111 3609 4186 3541 4024 M16689 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. 11/23 Gene Ontology BP GO:0034391 0.120941240751077 0.13566807944123 3460 3481.72727272727 3609 0.0116501090058133 2483 1.04235288485935 1.04235288485935 1 1.07120564185485 3456 3017 2507 2483 3657 3992 3609 4292 4119 3663 3504 4025 M15146 GO_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. 523/1375 Gene Ontology BP GO:0061024 8.4750637919378e-07 3.92711788283106e-06 4310 3039.09090909091 3611 8.4750670241413e-08 921 1.53779108895729 -1.32894646958597 -1 9.84794170079405 4308 3649 4360 3611 921 1195 3738 3967 1967 3193 2521 4026 M12863 GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). 7/17 Gene Ontology BP GO:1901070 0.202188850878346 0.222561127223367 1920 3158.81818181818 3613 0.0223351300921422 1777 0.565499037709678 -0.565499037709678 -1 0.437142018054027 1920 3613 3971 3882 3801 1777 1842 2883 4434 4363 2261 4027 M13474 GO_RNA_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DESTABILIZATION.html Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. 8/23 Gene Ontology BP GO:0050779 0.0943633829708779 0.106523021428103 2625 3382.36363636364 3613 0.00986275468949649 1975 1.082377024765 -1.082377024765 -1 1.24701286047187 2625 4071 4083 3613 4020 2536 4335 1975 4303 3394 2251 4028 M15159 GO_RESPONSE_TO_DEXAMETHASONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DEXAMETHASONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 16/45 Gene Ontology BP GO:0071548 0.0839184282471183 0.0949861682962873 2805 3374.45454545455 3613 0.00793650793650794 1241 2.00543520573001 1.52715822181804 1 2.42874339407081 2802 4494 1241 3763 3613 3884 3358 4507 3459 2265 3733 4029 M16796 GO_SPLEEN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLEEN_DEVELOPMENT.html The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. 19/48 Gene Ontology BP GO:0048536 0.00525088052345642 0.00722151607535787 4550 3548.63636363636 3613 0.000478495924847194 2361 1.04472831755898 -0.97523945994632 -1 2.65016695645912 4549 3879 2361 3696 3212 4140 3886 3286 3613 3087 3326 4030 M11101 GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 4/21 Gene Ontology BP GO:0042136 0.0870340743220536 0.0984167576905248 4250 3311.27272727273 3614 0.00906434094827325 1914 2.60901405415604 -2.60901405415604 -1 3.11210308501945 4249 2246 3690 1914 3614 4100 2665 3589 3850 2773 3734 4031 M13429 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 122/268 Gene Ontology BP GO:0015931 0.0839184282471183 0.0949861682962873 3510 3800.63636363636 3614 0.00793650793650794 2736 1.09283081546159 -1.07896968628479 -1 1.32350528281716 3509 4598 3468 4539 4107 3421 4521 2736 3614 4099 3195 4032 M10954 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. 38/71 Gene Ontology BP GO:2001021 0.000104778064156528 0.000189293599952825 4490 3628.09090909091 3615 9.5257322445932e-06 2444 1.69598756839356 -1.74756827544249 -1 7.47959095832737 4488 4425 2923 3615 2444 3520 4123 4188 2869 3727 3587 4033 M14150 GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The regulation of blood pressure mediated by detection of stimuli and a neurological response. 6/22 Gene Ontology BP GO:0001976 0.0377848899557431 0.0471853803293478 2345 3332.54545454545 3615 0.00384431624327055 1466 0.654780043049122 0.352970617213036 1 1.02867789249923 2341 3615 4192 4078 3494 2115 1466 3928 3993 4455 2981 4034 M14713 GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. 15/27 Gene Ontology BP GO:0009081 0.0356197731338966 0.0446497318198386 4305 3646.81818181818 3616 0.00329180970474636 2638 2.14100505140914 -0.775052495160171 -1 3.42442468721206 4302 3864 2638 3306 3470 3180 3616 4445 2851 3811 4632 4035 M15192 GO_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 34/99 Gene Ontology BP GO:0043331 0.0125191805286747 0.0164152937573106 3330 3685 3616 0.00114463583277583 3200 1.02555384346361 -0.776754077628212 -1 2.16827293238171 3996 3904 3200 3666 3326 3328 4509 3955 3607 3616 3428 4036 M12141 GO_REGULATION_OF_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of bone development. 9/31 Gene Ontology BP GO:1903010 0.0765897756730953 0.0916038970762961 3750 3383.27272727273 3617 0.00793650793650794 2380 2.33899415032813 -2.482161549779 -1 2.876340777859 3746 3226 3856 2762 3617 4336 3797 2776 2380 2678 4042 4037 M13261 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of B cell mediated immunity. 19/54 Gene Ontology BP GO:0002712 0.00705785695714648 0.00953992135430309 4540 3561.36363636364 3617 0.000643691055172127 2524 1.42831692722678 -1.59134389452951 -1 3.41862683617471 4536 4093 2625 4023 3263 4158 3617 2524 3399 3623 3314 4038 M12121 GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 15/43 Gene Ontology BP GO:0010743 0.298735036746822 0.322639398840543 3570 3467.72727272727 3619 0.0317460317460317 1737 1.59680577014279 -1.44897842494631 -1 0.929310388413649 3567 3256 1737 4202 3845 3619 2293 4236 3862 3334 4194 4039 M13163 GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY.html Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. 7/17 Gene Ontology BP GO:0006957 0.377950437738487 0.405364722203695 3125 3523.81818181818 3619 0.0463643042353148 2039 0.944503264501834 -0.949770503685069 -1 0.43876967516333 3123 2039 4027 3794 3876 2811 3419 3619 4087 4385 3582 4040 M14528 GO_MITOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_RECOMBINATION.html The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. 24/43 Gene Ontology BP GO:0006312 0.926305674764701 0.943994128167802 2130 3588.18181818182 3619 0.211068205486142 2127 0.590151011127798 -0.632524218819042 -1 0.0174973643699444 2127 3878 3129 3619 4365 2993 3160 3697 4532 4484 3486 4041 M15302 GO_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. 13/24 Gene Ontology BP GO:0055070 0.415320710913563 0.443499094013724 4605 3608.45454545455 3619 0.0476190476190476 2724 1.07791205404872 -0.60237417414133 -1 0.450885699231913 4603 3223 2813 2955 4269 3414 3619 2724 3929 3758 4386 4042 M10992 GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. 12/16 Gene Ontology BP GO:0045910 0.965989429929401 0.979277057458998 4635 3884.72727272727 3620 0.26462246993652 3190 0.176953835397779 0.17486417111218 1 0.00190471414630879 3221 4632 3190 4534 4495 3292 3370 3620 4632 4235 3511 4043 M12200 GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 38/100 Gene Ontology BP GO:0009118 0.0086366454926998 0.0115595113930831 3620 3557.09090909091 3620 0.00078824893723348 2353 0.991148611244456 0.964238183906561 1 2.27436282242781 3620 3308 2919 3379 3282 3984 4363 2353 3797 3996 4127 4044 M16731 GO_REGULATION_OF_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING.html Any process that modulates the frequency, rate or extent of protein targeting. 212/501 Gene Ontology BP GO:1903533 1.70906319667318e-06 6.36852361328536e-06 3490 3281.18181818182 3620 1.55369502214098e-07 1153 1.36803769034271 1.53758684429957 1 8.42057949162749 3486 3620 3072 2932 1153 3904 3774 3699 2446 3898 4109 4045 M16770 GO_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METABOLIC_PROCESS.html Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. 418/1006 Gene Ontology BP GO:0006259 0.0839184282471183 0.0949861682962873 2285 3673.63636363636 3620 0.00793650793650794 2284 1.08932184002159 -0.753637482387828 -1 1.31925562828001 2284 4401 3519 4546 3947 2831 3282 3880 3620 4630 3470 4046 M10698 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 8/14 Gene Ontology BP GO:0034244 0.00584161737063645 0.00796319126596155 2255 2805.09090909091 3621 0.000585703044696285 492 0.577531119653884 -0.577531119653884 -1 1.43597669204715 2255 3895 3621 4091 3921 1170 492 1201 4596 4216 1398 4047 M11209 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html The directed movement of a protein to a specific location in the endoplasmic reticulum. 71/216 Gene Ontology BP GO:0072599 0.134756142208042 0.150764522475166 2710 3375.63636363636 3621 0.0130723408797727 1486 0.598942828157824 -0.522653719414472 -1 0.583009928417264 2708 4275 3501 3621 4360 1486 1623 4570 4440 4251 2297 4048 M14409 GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of a different species. 430/1069 Gene Ontology BP GO:0044419 0.0839184282471183 0.0949861682962873 3640 3509.36363636364 3621 0.00793650793650794 1824 1.45128371241 -1.22496862677247 -1 1.75762088320359 3636 4578 3428 4543 3621 1824 3037 4078 2937 4038 2883 4049 M15607 GO_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of ATP metabolic process. 38/100 Gene Ontology BP GO:1903578 0.0086366454926998 0.0115595113930831 3625 3562.18181818182 3621 0.00078824893723348 2399 0.991148611244456 0.964238183906561 1 2.27436282242781 3621 3309 2920 3380 3283 3985 4364 2399 3798 3997 4128 4050 M16124 GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. 430/1069 Gene Ontology BP GO:0044403 0.0839184282471183 0.0949861682962873 3640 3508.54545454545 3622 0.00793650793650794 1825 1.45128371241 -1.22496862677247 -1 1.75762088320359 3637 4579 3429 4544 3622 1825 3038 4059 2938 4039 2884 4051 M11647 GO_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CONTRACTION.html A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. 22/55 Gene Ontology BP GO:0003009 0.0839184282471183 0.0949861682962873 4425 3465.09090909091 3623 0.00793650793650794 1766 2.50227772450882 -1.45914256153381 -1 3.03046007755519 3623 4340 1766 4300 4421 4423 3296 2563 1872 3317 4195 4052 M14634 GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. 4/19 Gene Ontology BP GO:0021527 0.0430700536403519 0.0534547605057883 2715 3543.27272727273 3623 0.00439283231304806 2666 2.37680021862279 -2.37680021862279 -1 3.58147839145555 4257 2715 4264 2666 3517 4353 3623 4252 2713 2794 3822 4053 M15423 GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 113/230 Gene Ontology BP GO:0006888 0.00656870437764628 0.00891154238995031 3900 3537.09090909091 3623 0.000598945402309098 1851 1.51069024144026 1.57626334733419 1 3.66874198956803 3900 3623 3039 4307 3248 4218 3524 2941 1851 3690 4567 4054 M10718 GO_DENDRITIC_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_CHEMOTAXIS.html The movement of a dendritic cell in response to an external stimulus. 5/38 Gene Ontology BP GO:0002407 0.210011165523943 0.23051580177959 2675 3505.27272727273 3624 0.0232979588812708 1396 0.465002982639879 0.580755272823159 1 0.351055030078239 2673 4507 3624 3967 4294 2844 1396 3263 4449 4218 3323 4055 M12191 GO_DNA_CONFORMATION_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE.html A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. 145/419 Gene Ontology BP GO:0071103 0.0839184282471183 0.0949861682962873 2295 3619.36363636364 3624 0.00793650793650794 2292 1.39491192365514 -0.978772172143486 -1 1.68935006400111 2292 4080 3211 4383 3920 3116 3477 4008 3567 4135 3624 4056 M10109 GO_ATP_DEPENDENT_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. 45/200 Gene Ontology BP GO:0043044 0.000207058717835652 0.000352797661251718 4335 3369.09090909091 3625 1.88252916612026e-05 1586 1.89207656371814 -0.926676487280574 -1 7.73832861256139 4332 3244 1586 3625 2595 4346 4226 3207 1750 3719 4430 4057 M10813 GO_COENZYME_A_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 7/17 Gene Ontology BP GO:0015936 0.0935152267954203 0.105591244652514 3900 3211 3626 0.00977006438824783 1756 0.794120619375041 -0.794120619375041 -1 0.918499947777593 2966 3896 3642 3900 3626 1756 1921 2313 4270 4221 2810 4058 M14922 GO_MULTI_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_METABOLIC_PROCESS.html A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. 92/247 Gene Ontology BP GO:0044033 0.0839184282471183 0.0949861682962873 3460 3650.72727272727 3626 0.00793650793650794 2524 1.10989191840971 -1.03004187915826 -1 1.34416766555317 3457 4369 3514 4277 4465 2524 2753 4051 3626 4136 2986 4059 M15278 GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. 127/372 Gene Ontology BP GO:0071824 0.0839184282471183 0.0949861682962873 3495 3549 3627 0.00793650793650794 2181 1.00052624169383 -0.894162111246868 -1 1.21171693963252 2181 3932 3282 4189 3800 3139 3493 3779 3627 4125 3492 4060 M13413 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G1_S_PHASE_TRANSITION.html The cell cycle process by which a cell in G1 phase commits to S phase. 65/140 Gene Ontology BP GO:0044843 0.161385165508919 0.178875942577683 2155 3466.81818181818 3628 0.0158730158730159 2154 1.30378338698996 -1.13332213262109 -1 1.15442024314857 2154 4226 3153 3788 4275 2797 2948 3628 3747 4034 3385 4061 M11133 GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 8/125 Gene Ontology BP GO:0048385 0.487075416606974 0.515028731338233 3630 3723.45454545455 3629 0.0645827995798928 2701 1.25677581248388 -1.25677581248388 -1 0.429023205503294 3629 4638 3698 4302 4226 3093 3601 2701 4490 3368 3212 4062 M10766 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. 9/21 Gene Ontology BP GO:0043302 1.68592212744273e-06 6.31778566401661e-06 4390 3285 3630 1.68592340649413e-07 1189 1.20701941901361 1.53432697482883 1 7.43444278220132 4387 1944 3630 2544 1189 3739 4286 4435 2142 3480 4359 4063 M14621 GO_DNA_GEOMETRIC_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_GEOMETRIC_CHANGE.html The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. 46/101 Gene Ontology BP GO:0032392 0.852946276156757 0.873451601278302 2735 3719.72727272727 3630 0.159928981264141 2731 0.353288843975212 -0.353288843975212 -1 0.0245905728670056 2731 4282 3366 4474 4127 2769 3085 3630 4570 4490 3393 4064 M12573 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 149/314 Gene Ontology BP GO:0010948 0.000236087741993304 0.000397589911525176 3155 3633.18181818182 3631 2.14648255447308e-05 2625 1.41324724526076 1.54560945067731 1 5.6930782885379 3151 4465 2971 4324 2625 4627 4104 3386 2672 3631 4009 4065 M16301 GO_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that modulates the frequency, rate or extent of neutrophil migration. 15/60 Gene Ontology BP GO:1902622 0.00120697934976437 0.00178927366569475 4500 3457.09090909091 3631 0.000109785640022749 1839 1.44268594994895 -1.51287603502927 -1 4.69525849094862 4496 3631 1839 3730 2953 4495 3984 3770 3492 2125 3513 4066 M10185 GO_ANTEROGRADE_AXONAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_AXONAL_TRANSPORT.html The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. 15/32 Gene Ontology BP GO:0008089 0.00563322438136505 0.00771080801965741 4055 3499.36363636364 3632 0.000513427317380937 2355 0.880462294670924 0.873457976145847 1 2.20377624888035 4055 3632 3179 3762 3228 2891 4229 2355 4068 3805 3289 4067 M12260 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. 101/247 Gene Ontology BP GO:1900182 8.00600997961612e-06 2.05710593997552e-05 4520 3421.09090909091 3633 7.27821737672637e-07 1691 1.37226645383862 -1.27878804159382 -1 7.61881842969351 4517 3874 2787 3051 1691 3374 4341 4079 2465 3820 3633 4068 M13360 GO_MITOCHONDRIAL_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_PROCESSING.html The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. 7/12 Gene Ontology BP GO:0000963 0.0969122666015175 0.109294062140113 1495 2985.90909090909 3633 0.0101417790382817 1495 0.866973501282713 -0.866973501282713 -1 0.987390294115765 1495 3926 4060 3872 3633 1664 1554 2135 3983 4401 2122 4069 M10378 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 7/17 Gene Ontology BP GO:0090141 0.0765897756730953 0.0916038970762961 3170 3825.72727272727 3636 0.00793650793650794 3088 0.936457813048449 -0.936457813048449 -1 1.15159306206238 3169 4350 3575 4548 4627 3632 3088 3976 3636 4198 3284 4070 M10749 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. 6/29 Gene Ontology BP GO:0051150 0.0369516757489799 0.0462070106389749 4275 3670.72727272727 3636 0.00375808938962635 2769 1.1878467257716 1.1878467257716 1 1.87894646487821 4274 2769 3628 3636 3492 4017 3861 3440 3733 3111 4417 4071 M15353 GO_SPERMATID_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_DIFFERENTIATION.html The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 70/283 Gene Ontology BP GO:0048515 0.00693278333360996 0.00938452274575833 4395 3698.63636363636 3636 0.000632247931353537 2824 1.24605661597529 -1.29875008375252 -1 2.99292135019406 4057 4329 3150 4394 3259 4393 3294 2824 3124 3636 4225 4072 M15790 GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT.html The progression of the atrioventricular valve over time, from its formation to the mature structure. 10/30 Gene Ontology BP GO:0003171 0.466738071388703 0.4949590645891 3210 3421.54545454545 3637 0.0555555555555556 2089 1.33530316458461 1.35688011403415 1 0.483135757017659 3210 3637 2102 3932 4158 3715 3195 4094 3978 2089 3527 4073 M16218 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. 364/1067 Gene Ontology BP GO:0000122 7.04858203467821e-07 3.50691032959052e-06 4010 3289.18181818182 3637 6.4078039027046e-08 808 1.44437540432646 -1.19427265570658 -1 9.3338079500041 4006 2999 2365 3997 808 3412 3853 4138 2840 3637 4126 4074 M10436 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 762/2161 Gene Ontology BP GO:0010629 1.57447160246715e-06 6.04654396216291e-06 3785 3486.54545454545 3638 1.57447271800063e-07 1162 1.44474690605914 1.69521153632425 1 8.93130417271856 3784 4144 3583 4550 1162 2418 3976 3608 2865 3638 4624 4075 M11879 GO_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 21/48 Gene Ontology BP GO:0032069 0.00098076264797389 0.00147463762128976 4590 3562 3638 8.92000132926661e-05 2548 0.837033030172875 -0.86063556010164 -1 2.8074276949487 4589 4160 3142 3384 2920 2548 3638 3049 4040 3937 3775 4076 M11611 GO_REGULATION_OF_INTERLEUKIN_10_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-10 secretion. 7/20 Gene Ontology BP GO:2001179 0.0765897756730953 0.0916038970762961 4285 3522.72727272727 3639 0.00793650793650794 2377 1.62243347665436 -1.98057969718709 -1 1.99516119462936 4284 2994 3776 3639 3809 4272 2790 4597 3493 2377 2719 4077 M11008 GO_LYMPHOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. 35/71 Gene Ontology BP GO:0002260 4.75174169021724e-05 9.38822836922495e-05 4280 3421.45454545455 3640 4.3198584776019e-06 2229 1.18221389142686 -0.955613131918669 -1 5.64027864276627 4280 2656 2532 2530 2229 3905 4504 3997 3222 3640 4141 4078 M11258 GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 22/46 Gene Ontology BP GO:1900739 0.0839184282471183 0.0949861682962873 3645 3378.72727272727 3641 0.00793650793650794 1122 1.74833727784236 -0.842294349395756 -1 2.11737690136504 3641 3490 2541 3774 4295 4248 3422 3035 1122 3733 3865 4079 M11661 GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 22/46 Gene Ontology BP GO:1900740 0.0839184282471183 0.0949861682962873 3645 3380 3642 0.00793650793650794 1123 1.74833727784236 -0.842294349395756 -1 2.11737690136504 3642 3491 2542 3775 4296 4249 3423 3039 1123 3734 3866 4080 M12223 GO_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 40/79 Gene Ontology BP GO:0032204 0.495420417685666 0.523614158733109 3520 3645.81818181818 3642 0.0602905232639675 2188 0.765254996703772 -0.843464854610554 -1 0.254724159208504 3518 4429 3290 4334 4619 2188 2548 3642 4441 4073 3022 4081 M12813 GO_CELL_REDOX_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_REDOX_HOMEOSTASIS.html Any process that maintains the redox environment of a cell or compartment within a cell. 35/76 Gene Ontology BP GO:0045454 0.253126660670887 0.274851984446896 4125 3455.36363636364 3642 0.0261837975850092 2335 1.63612983612305 -1.4087018545461 -1 1.08713005831688 3419 4124 2611 4123 4376 2439 2503 4533 3904 3642 2335 4082 M13267 GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. 7/21 Gene Ontology BP GO:0033605 9.99411172095432e-06 2.47217158872621e-05 4205 3145.72727272727 3642 9.99415666825992e-07 945 1.23531614000394 -0.651472299306776 -1 6.74166100287986 4203 945 4041 2129 1782 4528 4347 2062 3642 2384 4540 4083 M13506 GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. 11/28 Gene Ontology BP GO:0051570 0.111542784647076 0.125306835014849 3665 3598.90909090909 3643 0.0106941148310169 2747 1.00861198548302 -1.00861198548302 -1 1.07775547605205 3664 3610 3033 3612 3643 3104 3902 4486 4131 3656 2747 4084 M16916 GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. 9/21 Gene Ontology BP GO:0046112 0.828063714607741 0.849469692205864 4640 3713.72727272727 3643 0.161434957327703 2530 0.82915100755709 -0.82915100755709 -1 0.0695911537669285 3345 3643 4637 3714 4202 2980 2530 3273 4450 4640 3437 4085 M16331 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. 272/624 Gene Ontology BP GO:0045786 3.93684450319176e-06 1.1635117140878e-05 3110 3461.63636363636 3645 3.57895595281213e-07 1478 1.3420244310895 1.45784772298894 1 7.84436427605529 3109 4220 2990 4178 1478 4490 3645 3763 2921 3439 3845 4086 M13827 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. 4/17 Gene Ontology BP GO:0001956 2.65111891427304e-05 5.65937706619297e-05 3720 3168.27272727273 3646 2.65115054274583e-06 861 1.38040838385514 1.38040838385514 1 6.94530791761676 3716 861 4139 2437 2087 4276 3219 3895 3646 2791 3784 4087 M14407 GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. 65/140 Gene Ontology BP GO:0000082 0.161385165508919 0.178875942577683 2155 3469.36363636364 3646 0.0158730158730159 2155 1.30378338698996 -1.13332213262109 -1 1.15442024314857 2155 4227 3154 3789 4276 2798 2949 3646 3748 4035 3386 4088 M16342 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM.html Any process that modulates the frequency, rate or extent of defense response to bacterium. 7/15 Gene Ontology BP GO:1900424 0.000269809675480538 0.00044820262012742 4000 2925.45454545455 3648 2.69842439846877e-05 607 1.69624277870725 -1.78744494726175 -1 6.72852126949027 3998 1444 4551 607 2670 3648 4030 3957 887 2408 3980 4089 M11710 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. 19/53 Gene Ontology BP GO:0036092 0.00575527256711543 0.00785702161985209 3715 3545.90909090909 3651 0.000524580356687589 2732 1.08775331527728 -1.12181595183895 -1 2.71210891411757 3711 3662 2732 3651 3231 3480 4027 3916 3943 3622 3030 4090 M12587 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization. 11/39 Gene Ontology BP GO:0031113 0.0839184282471183 0.0949861682962873 3655 3654.27272727273 3652 0.00793650793650794 2995 1.09024807534722 1.09024807534722 1 1.32037737456218 3569 3441 2995 3652 3782 4348 4047 3368 3400 3652 3943 4091 M15033 GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. 11/54 Gene Ontology BP GO:0045581 0.00993433203119221 0.0131786010345216 3695 3473.27272727273 3652 0.000907225201393396 2602 1.15078365138924 -1.29319575997802 -1 2.56306451911974 3692 2928 2602 4201 3299 3079 3632 3671 3791 3659 3652 4092 M10901 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. 9/29 Gene Ontology BP GO:2000144 0.0321835444833468 0.0406054883250487 3830 3652.27272727273 3654 0.00326593736156179 2502 0.605788875727792 0.605788875727792 1 0.998516916640095 3826 3410 3654 3238 3464 4451 2973 2502 4107 4228 4322 4093 M14514 GO_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. 11/26 Gene Ontology BP GO:0030219 0.00515335832515656 0.0070915953478666 3310 3552 3654 0.000469588133748958 2603 0.732213695236796 0.732213695236796 1 1.8642481300425 3309 3810 3004 4293 3206 3654 2836 2603 4039 4483 3835 4094 M14921 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT.html Any process that activates or increases the frequency, rate or extent of protein import. 82/215 Gene Ontology BP GO:1904591 1.14051680981935e-05 2.7652321399432e-05 4130 3368.90909090909 3655 1.0368388386293e-06 1790 1.53993689221066 -1.45969196548309 -1 8.31535569934689 4130 3655 2538 2351 1790 4309 4136 3911 2212 3608 4418 4095 M15861 GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an androgen binding to its receptor. 24/55 Gene Ontology BP GO:0030521 0.0831035261343933 0.0949861682962873 3655 3350.81818181818 3655 0.00785631381390593 1817 1.94348630456369 2.0747301729369 1 2.35371823831941 3655 4061 2106 3106 3830 4621 4439 1893 1817 2964 4367 4096 M10453 GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. 42/140 Gene Ontology BP GO:0046634 0.0839184282471183 0.0949861682962873 4130 3665.45454545455 3657 0.00793650793650794 2404 1.43233827395874 -1.4275480701839 -1 1.73467641697701 4127 4334 2404 4120 3639 3325 4450 4224 3432 2608 3657 4097 M11000 GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION.html The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. 14/26 Gene Ontology BP GO:0006271 0.984059009817387 0.994467127727277 3335 3791 3658 0.313576253225321 3225 0.71112730430769 -0.71112730430769 -1 0.00202817150247721 3332 3440 3225 4168 4380 3433 3658 3593 4460 4236 3776 4098 M13091 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. 63/138 Gene Ontology BP GO:0002474 0.0839184282471183 0.0949861682962873 3575 3724.36363636364 3658 0.00793650793650794 2563 1.34751599803467 -0.973303405386469 -1 1.63194974479107 3572 4543 3224 4420 4415 2563 2876 4409 3385 3903 3658 4099 M14287 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. 245/631 Gene Ontology BP GO:1901361 0.0839184282471183 0.0949861682962873 3660 3468.18181818182 3658 0.00793650793650794 1720 1.51288375336942 -1.15783131626833 -1 1.83222354088214 3658 4358 3435 4336 3972 1720 2491 3789 2975 4029 3387 4100 M11046 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION.html Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. 7/17 Gene Ontology BP GO:0032928 0.111296807165518 0.125060763714787 2765 3416.90909090909 3659 0.0117298590115623 1904 0.75064689990127 -0.75064689990127 -1 0.802864772035925 2761 4043 3675 3765 3659 2472 1904 3587 4514 4241 2965 4101 M12489 GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS.html The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. 18/42 Gene Ontology BP GO:0006904 0.00154286921898751 0.00225410377084928 3175 3682.45454545455 3659 0.000140359300289587 3003 0.955658102390662 1.02331567254036 1 2.99666797618124 4572 3180 3173 3530 3003 3659 4049 3171 3908 3890 4372 4102 M11278 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY.html Any process that increases the activity of triglyceride lipase. 3/15 Gene Ontology BP GO:0061365 0.435369722646862 0.463948042747161 3485 3566.81818181818 3660 0.0555555555555556 1879 0.282643619057972 -0.336782728733712 -1 0.111672567335968 3481 1879 3722 2956 4205 3660 3629 4093 3963 4257 3390 4103 M13264 GO_NEUTRAL_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. 9/30 Gene Ontology BP GO:0046461 0.0765897756730953 0.0916038970762961 3120 3590.36363636364 3660 0.00793650793650794 2688 2.1043057780036 -1.09882060606045 -1 2.58773632367719 3117 4104 4040 3922 3931 4014 3660 3389 3356 2688 3273 4104 M14211 GO_ACYLGLYCEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 9/30 Gene Ontology BP GO:0046464 0.0765897756730953 0.0916038970762961 3120 3605.90909090909 3661 0.00793650793650794 2691 2.1043057780036 -1.09882060606045 -1 2.58773632367719 3118 4105 4205 3923 3932 4015 3661 3384 3357 2691 3274 4105 M12266 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. 4/13 Gene Ontology BP GO:0043371 0.113847206266955 0.127771955208477 4125 3609.36363636364 3662 0.0120138395580383 2779 1.671870531444 -1.671870531444 -1 1.76972676346007 4121 3391 3879 3462 3662 3571 2919 4191 4041 2779 3687 4106 M15480 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. 4/17 Gene Ontology BP GO:0046639 0.113847206266955 0.127771955208477 4125 3660.18181818182 3663 0.0120138395580383 2796 1.671870531444 -1.671870531444 -1 1.76972676346007 4122 3392 4414 3463 3663 3572 2920 4190 4042 2796 3688 4107 M10980 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 8/24 Gene Ontology BP GO:0071276 0.0765897756730953 0.0916038970762961 4360 3499.54545454545 3665 0.00793650793650794 2453 2.58373837981968 -2.58373837981968 -1 3.17731126935349 4358 3048 3665 2453 3744 4482 4132 2581 2906 3366 3760 4108 M11674 GO_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPAIR.html Any process that modulates the frequency, rate or extent of DNA repair. 48/109 Gene Ontology BP GO:0006282 0.442007225688747 0.470265707807711 4105 3443.81818181818 3665 0.0516552722835268 2113 0.751529718057302 -0.612184538555536 -1 0.291702932611711 2523 4229 3269 4265 4104 2113 2323 3665 4238 4105 3048 4109 M14166 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. 10/21 Gene Ontology BP GO:0032717 0.00578756683034891 0.00789646570476345 3975 3672.09090909091 3665 0.000527531687752803 2641 0.407986260516594 -0.462137995233976 -1 1.01618508330466 3974 3350 2946 3827 3234 3665 4613 2641 4192 4456 3495 4110 M10981 GO_SUCKLING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUCKLING_BEHAVIOR.html Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. 7/21 Gene Ontology BP GO:0001967 0.0386493815025411 0.0482130785374256 3540 3784.54545454545 3666 0.00393385095596802 2995 0.414380388549527 -0.422410731851033 -1 0.646409263048924 3538 2995 3666 3930 3498 3177 4531 4381 4345 4233 3336 4111 M14223 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. 6/28 Gene Ontology BP GO:0032695 0.02801788303723 0.0355526184591033 4050 3493.72727272727 3667 0.00283775323245913 2189 1.33940053292997 -1.671870531444 -1 2.29929725904417 4050 3232 4208 3811 3442 3401 4216 2430 3785 2189 3667 4112 M12196 GO_BASE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASE_EXCISION_REPAIR.html In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. 24/43 Gene Ontology BP GO:0006284 0.0839184282471183 0.0949861682962873 3725 3401.81818181818 3668 0.00793650793650794 959 3.10646585646244 -0.654162550255648 -1 3.76218102578105 3723 3489 2809 3668 3899 3613 4015 3247 959 3976 4022 4113 M15110 GO_CATECHOLAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_TRANSPORT.html The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 2/17 Gene Ontology BP GO:0051937 0.347234296854444 0.373363735655945 2900 3485.9 3668.5 0.0462874866544554 1593 0.521781820512482 -0.521781820512482 -1 0.264468502181259 2900 1593 4355 NA 3874 2419 3463 4142 4533 4523 3057 4114 M16439 GO_DOPAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_TRANSPORT.html The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 2/13 Gene Ontology BP GO:0015872 0.347234296854444 0.373363735655945 2905 3516 3669.5 0.0462874866544554 1594 0.521781820512482 -0.521781820512482 -1 0.264468502181259 2901 1594 4566 NA 3875 2420 3464 4137 4534 4611 3058 4115 M10466 GO_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DEGRANULATION.html The regulated exocytosis of secretory granules by a leukocyte. 20/68 Gene Ontology BP GO:0043299 0.440289892401436 0.468760827888069 3750 3503.36363636364 3670 0.0513903046862828 2276 1.10893959882823 -0.607739551216347 -1 0.43225942017469 3748 3369 2276 3225 4242 4588 2669 2610 4084 3670 4056 4116 M11004 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 5/18 Gene Ontology BP GO:0060261 0.136937754799545 0.153131501814616 3300 3559.63636363636 3670 0.0146189367662975 2743 0.732213695236796 0.732213695236796 1 0.706867689183944 4227 2743 3670 3086 3694 3299 3298 3144 3802 4237 3956 4117 M16658 GO_LOCOMOTORY_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_EXPLORATION_BEHAVIOR.html The specific movement from place to place of an organism in response to a novel environment. 8/24 Gene Ontology BP GO:0035641 0.0011634721683792 0.00172753478662764 4120 3463 3670 0.000116408176798916 2243 1.18413748849843 -0.751976009954791 -1 3.87519747034439 4118 2243 4597 2478 2964 4289 3240 4072 3670 2549 3873 4118 M11801 GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. 22/37 Gene Ontology BP GO:1900087 0.437348695931526 0.465949975954584 3065 3488.27272727273 3671 0.0509382191216535 2810 0.955261546398286 1.08874219604097 1 0.375312019216703 3065 3908 2810 3874 3894 3687 3106 2968 4070 3318 3671 4119 M14785 GO_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-8 secretion. 10/21 Gene Ontology BP GO:2000482 0.232850105696956 0.253922063757934 4290 3434.72727272727 3672 0.0238095238095238 1657 1.5465248701425 1.55197843219228 1 1.09061107245769 4289 3188 1657 3218 3955 3476 3672 4255 3803 2082 4187 4120 M11032 GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 7/16 Gene Ontology BP GO:0071545 0.36756370167945 0.394497981252355 3595 3765.63636363636 3673 0.0447838010205506 2795 1.05298836246055 -1.05298836246055 -1 0.503887334949263 3594 4641 3673 3716 3868 2795 4523 3542 4510 3272 3288 4121 M11560 GO_SULFATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATION.html The addition of a sulfate group to a molecule. 5/26 Gene Ontology BP GO:0051923 0.000458007965691856 0.000731210375051744 4570 3122.72727272727 3674 4.58102390166362e-05 105 2.56210419863613 -2.41144211048533 -1 9.51798471114924 4569 3674 3769 1821 2769 4027 4318 2961 105 1969 4368 4122 M13258 GO_FC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 108/363 Gene Ontology BP GO:0038093 0.0839184282471183 0.0949861682962873 4055 3367.72727272727 3674 0.00793650793650794 1408 1.86709052068232 -1.12842870605062 -1 2.26119673307008 4053 4599 3064 3724 4264 2302 3674 3277 1408 3959 2721 4123 M15172 GO_ESTROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 5/23 Gene Ontology BP GO:0006703 0.0361172283709728 0.0452366580324863 3005 3203.09090909091 3675 0.00367180218356477 1347 0.611995773108909 -0.611995773108909 -1 0.974741924847132 3002 3675 4367 4080 4535 1633 1347 1670 4386 4530 2009 4124 M10086 GO_MEIOTIC_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. 29/69 Gene Ontology BP GO:0045132 0.133419689904486 0.14930528325537 2050 3561.27272727273 3677 0.0129338558421784 2048 0.817406431507993 0.888727210494804 1 0.799752780209448 2048 4157 2921 4409 3677 2807 2547 4623 4313 4017 3655 4125 M11866 GO_AMINO_ACID_BETAINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_TRANSPORT.html The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/40 Gene Ontology BP GO:0015838 0.0329172664287372 0.0414682979991495 4125 3580.36363636364 3678 0.00334152765207146 2444 0.747810951717757 0.747810951717757 1 1.22452185627566 4125 2444 3818 2781 3477 3466 4114 3183 4007 4291 3678 4126 M11057 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 6/14 Gene Ontology BP GO:0033147 0.158053726310623 0.175855128507122 3630 3645.63636363636 3679 0.0170567652736309 2963 1.01483800181552 -1.01483800181552 -1 0.907468960213295 3630 4260 3679 3883 3712 2963 4120 3109 4373 3115 3258 4127 M12451 GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. 6/12 Gene Ontology BP GO:0009396 0.0765897756730953 0.0916038970762961 4320 3664.90909090909 3680 0.00793650793650794 2245 1.71190735265211 1.71190735265211 1 2.1051903319492 4316 2245 3909 3115 3680 4594 4406 3328 2973 3125 4623 4128 M16315 GO_CENTROMERE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROMERE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. 28/52 Gene Ontology BP GO:0034508 0.0839184282471183 0.0949861682962873 2780 3516.72727272727 3681 0.00793650793650794 2055 1.61861941195405 -1.05518540161294 -1 1.96027801972577 2779 3939 2055 4208 3811 3205 3556 4047 3488 3681 3915 4129 M16259 GO_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. 928/2309 Gene Ontology BP GO:0009056 3.69736133509651e-07 2.54323684131157e-06 3685 3150.54545454545 3682 3.69736195026829e-08 564 1.55570518285003 -1.27750744729856 -1 10.3103971557672 3682 4508 4536 4611 564 822 2944 4316 2472 3979 2222 4130 M12077 GO_NEGATIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BINDING.html Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 25/89 Gene Ontology BP GO:0043392 0.0357261973627184 0.0447589677158935 4275 3681.90909090909 3683 0.00330180945934568 2659 1.39882388248031 -1.02719472535562 -1 2.23558596332231 4272 3683 2659 4030 3473 3371 4395 3319 3745 3534 4020 4131 M14408 GO_CELLULAR_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 23/62 Gene Ontology BP GO:0071359 0.0175989517539742 0.0227609841208085 4470 3818.27272727273 3684 0.00161284837479888 3194 1.02092231299825 -0.786420834257832 -1 1.98681529099882 4467 3684 3214 3194 3371 4551 3809 4413 3610 3414 4274 4132 M11828 GO_PROTEIN_LOCALIZATION_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_LYSOSOME.html A process in which a protein is transported to, or maintained in, a location within a lysosome. 18/30 Gene Ontology BP GO:0061462 0.169165879267899 0.187365738893333 3165 3385.27272727273 3685 0.0167066085526544 2141 0.985515383942352 -0.985515383942352 -1 0.849102463383869 3164 4386 3119 3965 4223 2141 3685 2262 4248 3889 2156 4133 M10397 GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 85/214 Gene Ontology BP GO:0046488 4.69004396577876e-05 9.27422237355656e-05 3690 3607.90909090909 3689 4.2637672299184e-06 2226 1.29889788479938 -1.11961550975691 -1 6.20513638301862 4614 4367 2956 4017 2226 3450 3689 4119 2688 3687 3874 4134 M10408 GO_AXO_DENDRITIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXO_DENDRITIC_TRANSPORT.html The directed movement of organelles or molecules along microtubules in neuron projections. 22/46 Gene Ontology BP GO:0008088 0.0006895586747706 0.00106578592774963 4370 3670.72727272727 3689 6.27068092733997e-05 2837 1.06987085880963 1.29307611190594 1 3.76709258121463 4368 3285 3136 3093 2837 3709 4529 3689 3419 3732 4581 4135 M13560 GO_BICARBONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSPORT.html The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 16/52 Gene Ontology BP GO:0015701 0.0525065443931331 0.0645624697079759 3120 3397.27272727273 3689 0.00489120337567091 1058 1.52811681232484 1.21820159800009 1 2.1542124304416 3116 2759 1058 3098 3689 4395 4427 4297 3964 2852 3715 4136 M14053 GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. 24/77 Gene Ontology BP GO:0050710 0.0839184282471183 0.0949861682962873 4590 3509.81818181818 3690 0.00793650793650794 1748 1.85486612366503 -1.73542116267601 -1 2.24639199443998 4586 3284 1748 3035 4013 3690 4542 4148 2902 2502 4158 4137 M16690 GO_PROSTANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. 9/30 Gene Ontology BP GO:0046457 0.0562098985709826 0.0688971908830708 3690 3645.81818181818 3690 0.00576844702384457 1798 1.76665821405798 -1.76665821405798 -1 2.43142649082818 3690 4636 4606 4552 4305 2782 3178 1798 3911 3516 3130 4138 M10203 GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT.html The directed movement of substances from endoplasmic reticulum to cytosol. 12/32 Gene Ontology BP GO:1903513 0.146557101904591 0.163533915919975 2460 3276.81818181818 3691 0.0143036837148638 2083 1.08779448467789 -1.08779448467789 -1 1.01335919046358 2456 4101 3059 4236 3924 2140 2114 4132 4109 3691 2083 4139 M12020 GO_HISTONE_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MONOUBIQUITINATION.html The modification of histones by addition of a single ubiquitin group. 19/26 Gene Ontology BP GO:0010390 0.349977069004031 0.376144335968916 3520 3739.18181818182 3691 0.0384020780193982 2687 0.673348897277562 -0.353288843975212 -1 0.338721370358851 3517 3687 3148 4176 3851 2687 3691 4014 4559 4307 3494 4140 M11109 GO_IMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving IMP, inosine monophosphate. 7/14 Gene Ontology BP GO:0046040 0.235015706247242 0.256084938771637 3755 3604.81818181818 3692 0.0264343288540391 2374 0.978220213186551 0.933350721334644 1 0.68557275873344 3753 3646 3692 3690 3784 3814 3056 3141 4338 2374 4365 4141 M13246 GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 72/165 Gene Ontology BP GO:0072522 1.23275650575966e-05 2.95797853035767e-05 3715 3498.45454545455 3692 1.12069401226301e-06 1810 1.26550815036495 1.49019392962905 1 6.78962423090661 3715 3201 2796 3692 1810 4066 4579 3756 3165 3229 4474 4142 M15712 GO_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that modulates the frequency, rate, or extent of receptor recycling. 11/26 Gene Ontology BP GO:0001919 0.22825069776097 0.249650880966828 2820 3389.72727272727 3693 0.0232789046426779 2041 0.505050194836691 -0.505050194836691 -1 0.360568643892026 2820 3693 2741 3837 3759 2787 2041 3821 4465 4572 2751 4143 M13503 GO_MEGAKARYOCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. 10/21 Gene Ontology BP GO:0035855 0.00176164984380618 0.00255205623238443 3640 3639.72727272727 3694 0.000160278369838305 2723 0.732213695236796 0.732213695236796 1 2.24924376065843 3639 3694 3061 3947 3034 4033 3377 2723 3942 4417 4170 4144 M13508 GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. 131/273 Gene Ontology BP GO:0045930 0.000119558980449833 0.000213504748549451 4330 3692.90909090909 3694 1.08695889432682e-05 2470 1.45058424524762 -1.1934076938948 -1 6.30749784032349 4329 4362 2866 4259 2470 3585 4212 3694 2787 3667 4391 4145 M11873 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE.html A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 12/19 Gene Ontology BP GO:0033539 0.399663954954837 0.427566761026569 3470 3402.09090909091 3695 0.0453283230739443 1728 1.21750281449381 1.21750281449381 1 0.53219211650826 3469 3979 3056 3953 4027 2490 1728 3746 4301 3695 2979 4146 M15284 GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS.html Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. 8/15 Gene Ontology BP GO:0051457 0.692053852342561 0.719159811196623 3695 3751.27272727273 3695 0.111111111111111 2897 0.723069420775113 0.723069420775113 1 0.122636032067009 3695 3078 4380 3373 4192 2897 3247 4070 4182 4540 3610 4147 M10881 GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. 8/20 Gene Ontology BP GO:0000380 0.184626271745029 0.203905751596615 3505 3701.18181818182 3698 0.0202039790377281 2383 0.1584500073657 -0.0938429058443607 -1 0.129620224056408 3503 3698 3651 3333 3728 4287 2383 3450 4452 4226 4002 4148 M13106 GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION.html Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. 12/20 Gene Ontology BP GO:0000394 0.0179457505792763 0.0231772239053073 3700 3318.81818181818 3698 0.00164489370829219 957 3.26707235433041 -3.26707235433041 -1 6.32758782876504 4082 3887 2882 4074 4469 3950 3360 1451 957 3698 3697 4149 M11240 GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION.html The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. 7/14 Gene Ontology BP GO:0036508 0.0037966488233292 0.00529046833334858 2200 3099.90909090909 3699 0.000380315100760071 991 0.769233880183894 -0.769233880183894 -1 2.07445935553602 2199 3813 3714 3699 4108 1611 2128 3164 4419 4253 991 4150 M11161 GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL.html Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 4/21 Gene Ontology BP GO:0045760 0.235141350268742 0.256161729070336 2585 3466.90909090909 3700 0.0264503202605162 2425 0.489491560602656 0.595040722057775 1 0.342977373067148 2582 4022 3700 4349 3785 2425 2687 2966 4226 4248 3146 4151 M12900 GO_PROTEIN_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMANNOSYLATION.html The removal of one or more mannose residues from a mannosylated protein. 7/14 Gene Ontology BP GO:0036507 0.0037966488233292 0.00529046833334858 2200 3133.36363636364 3700 0.000380315100760071 992 0.769233880183894 -0.769233880183894 -1 2.07445935553602 2200 3814 3976 3700 4109 1612 2129 3149 4420 4366 992 4152 M13470 GO_PROTEIN_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MONOUBIQUITINATION.html Addition of a single ubiquitin group to a protein. 31/65 Gene Ontology BP GO:0006513 0.605775399001801 0.633757363128743 2905 3528.63636363636 3700 0.0811398240608246 2497 0.738149309388829 -0.725916673030107 -1 0.173201684952044 2903 3859 3212 4040 4338 2497 3064 3700 4327 4027 2848 4153 M11173 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. 9/22 Gene Ontology BP GO:2000010 7.11690631768785e-07 3.5265524048052e-06 3865 2704.90909090909 3701 7.11690859695487e-08 81 2.89789300500517 -2.22782404629529 -1 18.7183689680372 3862 1123 3701 966 856 4468 4489 4348 81 1907 3953 4154 M12286 GO_PEPTIDYL_LYSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_MODIFICATION.html The modification of peptidyl-lysine. 179/381 Gene Ontology BP GO:0018205 0.0839184282471183 0.0949861682962873 3530 3709.81818181818 3701 0.00793650793650794 2165 1.19098133294073 -0.932925417758763 -1 1.4423735391109 3529 4593 3465 4601 4337 2165 4175 3701 3555 4143 2544 4155 M16116 GO_PEPTIDYL_METHIONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_METHIONINE_MODIFICATION.html The modification of peptidyl-methionine. 7/12 Gene Ontology BP GO:0018206 0.315606688737793 0.34007005240417 2450 3438.63636363636 3701 0.0372122062452584 1945 0.210678849319217 -0.228189356316765 -1 0.116906588474998 2447 3701 4513 3893 4171 1945 2271 3213 4282 4592 2797 4156 M15333 GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. 7/14 Gene Ontology BP GO:0006047 0.131732265547415 0.147488041701627 3280 3618.81818181818 3702 0.0140262191915771 2110 0.869627999721166 -0.869627999721166 -1 0.856325474620469 3279 3702 4390 3941 4490 2848 3189 2110 4319 4544 2995 4157 M10377 GO_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. 27/78 Gene Ontology BP GO:0031060 0.000602843496821023 0.000945928474396759 3705 3527.90909090909 3704 5.48189773870721e-05 2538 1.06551574204605 -0.923336157146244 -1 3.81715607487621 3704 3792 3171 3910 2802 3051 4162 4199 3617 3861 2538 4158 M16854 GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY.html Any process that modulates the activity of the enzyme protein phosphatase type 2A. 10/25 Gene Ontology BP GO:0034047 0.0839184282471183 0.0949861682962873 4285 3310.63636363636 3704 0.00793650793650794 367 1.89121657864655 -0.554170537432062 -1 2.29041535071067 4283 3075 2760 2631 3767 3704 3932 4517 367 3598 3783 4159 M11541 GO_MAGNESIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSPORT.html The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 3/15 Gene Ontology BP GO:0015693 0.254671174176486 0.276464405354553 1890 3180.63636363636 3705 0.0289652059344802 1493 0.377509776170118 0.377509776170118 1 0.24969985008325 1886 3705 3766 4203 4026 2062 1493 2423 4415 4277 2731 4160 M12537 GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE.html Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. 7/13 Gene Ontology BP GO:0099500 0.0355126197979455 0.0445274355176508 3650 3632.63636363636 3706 0.00360932377645926 1699 0.705641235913326 -0.705641235913326 -1 1.12963053963599 3649 4136 3926 3706 3484 3751 4130 1699 3562 4345 3571 4161 M16666 GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 12/39 Gene Ontology BP GO:0035458 0.00262984831740054 0.00373292135056274 4085 3572.27272727273 3706 0.000239363388306165 2670 1.00292597704778 -1.13989251988388 -1 2.8846071461723 4081 2670 3012 2920 3104 3851 4222 4319 3805 3706 3605 4162 M15910 GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE.html Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. 7/13 Gene Ontology BP GO:0031629 0.0344163300636896 0.0432112007803436 3650 3700.90909090909 3707 0.00349612638567436 1654 0.705641235913326 -0.705641235913326 -1 1.14052363766157 3650 4137 4478 3707 3485 3752 4131 1654 3563 4581 3572 4163 M14886 GO_MACROMOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. 509/1194 Gene Ontology BP GO:0009057 0.0390288006319903 0.0486341173736798 3715 3532.45454545455 3712 0.0039731699808363 1067 1.3865346710644 -1.01543213646061 -1 2.15671483113579 3712 4576 4310 4602 4585 1067 2889 3639 3052 4160 2265 4164 M14950 GO_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_LINEAGE_COMMITMENT.html The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. 6/16 Gene Ontology BP GO:0002360 0.0765897756730953 0.0916038970762961 3715 3433 3713 0.00793650793650794 2196 1.13582766344944 -0.810439928653025 -1 1.39676510141558 3713 2711 4323 2723 3771 4600 4141 2898 2617 2196 4070 4165 M11482 GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. 42/77 Gene Ontology BP GO:0072384 0.121568864078929 0.136306263201755 4350 3691.81818181818 3714 0.0117142802100095 2772 1.17556284309572 1.13471091249841 1 1.20526483083186 4350 3628 3080 3905 3658 3714 2772 3465 3808 3952 4278 4166 M15874 GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 21/58 Gene Ontology BP GO:0072523 2.03394049330657e-06 7.23646414591756e-06 4235 3261.81818181818 3716 1.84903852156766e-07 1216 1.19666644601403 1.51327270143228 1 7.28709190770156 4234 2062 2514 3920 1216 4057 4038 2756 2957 3716 4410 4167 M11257 GO_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOOD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. 7/27 Gene Ontology BP GO:0032094 0.259302207725721 0.281360166036579 2270 3279 3717 0.029570243298904 1905 0.762844192101928 0.762844192101928 1 0.497687850647604 2268 3819 3717 2837 4074 2487 1905 4322 4002 4255 2383 4168 M16029 GO_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group. 34/62 Gene Ontology BP GO:0043967 0.0839184282471183 0.0949861682962873 3515 3629.36363636364 3718 0.00793650793650794 2501 1.13699961124235 -0.830464437579191 -1 1.37699728542601 3513 4486 3388 4594 3761 2501 3718 3741 3504 3827 2890 4169 M16827 GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 9/22 Gene Ontology BP GO:0071371 0.0559094985334789 0.068547082569565 4020 3658.27272727273 3718 0.00573680604503326 2476 1.68725121457601 -1.68725121457601 -1 2.32656200176544 4020 3323 4622 3642 3555 3890 4565 2476 3718 2707 3723 4170 M15862 GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 9/16 Gene Ontology BP GO:0032785 0.00129506661046326 0.00191496632878373 1830 2805.18181818182 3720 0.000129582196897509 265 0.577531119653884 -0.577531119653884 -1 1.85941702539584 1829 3720 4469 4352 3790 838 265 1074 4582 4579 1359 4171 M16277 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. 22/34 Gene Ontology BP GO:0000291 0.930240289349962 0.947795844514346 3015 3880.63636363636 3720 0.214993682436227 3007 0.667883205792003 -0.667883205792003 -1 0.018421243617689 3013 4626 3341 4258 4440 3007 3679 3720 4588 4601 3414 4172 M11883 GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. 9/22 Gene Ontology BP GO:0035067 0.748019083419478 0.77454339971379 3875 3670.90909090909 3721 0.128762088781647 2613 0.278204981833201 -0.272931880030267 -1 0.0365651149733154 3871 3721 3820 3434 4289 2613 3041 3685 4527 4292 3087 4173 M16215 GO_DNA_PACKAGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING.html Any process in which DNA and associated proteins are formed into a compact, orderly structure. 102/328 Gene Ontology BP GO:0006323 0.0839184282471183 0.0949861682962873 3880 3621.18181818182 3721 0.00793650793650794 2622 1.46001336613514 -1.04132050496031 -1 1.76819320358464 2871 3678 2622 3721 3815 3498 3880 4388 3445 4036 3879 4174 M11945 GO_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_FORMATION.html The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 8/26 Gene Ontology BP GO:0003272 0.232967984096387 0.253972845775892 3450 3602.63636363636 3722 0.0261740366291937 2354 1.04146276741192 -1.04146276741192 -1 0.734333017010252 3449 3722 3831 4160 4596 3111 3864 2354 4273 3378 2891 4175 M16546 GO_RESPONSE_TO_MANGANESE_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MANGANESE_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. 10/30 Gene Ontology BP GO:0010042 0.0839184282471183 0.0949861682962873 3785 3283.18181818182 3724 0.00793650793650794 1966 1.92324409724041 1.16473306712766 1 2.32920327956164 3783 3840 2037 2455 3724 4625 4314 1966 2269 2844 4258 4176 M10904 GO_NEGATIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPAIR.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. 6/17 Gene Ontology BP GO:0045738 0.766862053196885 0.792993432737892 3495 3836.63636363636 3725 0.135507366861858 2800 0.137183211149593 -0.175314329445962 -1 0.0163679784822551 3493 4639 3656 4493 4391 2800 3098 3725 4594 4229 3085 4177 M13832 GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM.html A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. 129/471 Gene Ontology BP GO:0022412 1.5891529739616e-05 3.65993911612287e-05 3815 3449.36363636364 3726 1.44469495745564e-06 1892 1.35855028128942 -1.42581114522554 -1 7.13997614415904 3814 4116 2821 4010 1892 4475 3170 2638 2848 3726 4433 4178 M16132 GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. 3/22 Gene Ontology BP GO:0002523 0.00650492702525663 0.00883110414569196 2755 3176.63636363636 3726 0.000652404717736623 772 0.361600768527545 0.501655436470076 1 0.879840365376422 2753 3726 4515 3945 4292 2210 772 1222 4558 4593 2357 4179 M12024 GO_SOMATIC_CELL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_CELL_DNA_RECOMBINATION.html Recombination occurring within or between DNA molecules in somatic cells. 16/36 Gene Ontology BP GO:0016444 0.0839184282471183 0.0949861682962873 3960 3699.63636363636 3727 0.00793650793650794 2790 0.985381549897987 -0.63365473054087 -1 1.19337548660593 3960 2790 2834 3727 4615 3540 3694 4487 3047 3834 4168 4180 M15747 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 5/18 Gene Ontology BP GO:2000515 0.0454038240274805 0.0562010010556097 3730 3546.54545454545 3727 0.00463590887876744 1991 1.46807889378281 -1.671870531444 -1 2.17433316563426 3727 3103 4451 3349 3523 3987 4139 2687 3878 1991 4177 4181 M12794 GO_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. 146/316 Gene Ontology BP GO:0019882 0.000102765052949627 0.000185801456715388 4625 3669.81818181818 3728 9.34271396016374e-06 2442 1.37568957521339 -1.24510907806765 -1 6.08020132651631 4624 3728 2627 4343 2442 3452 4642 4088 3010 3412 4000 4182 M14068 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS.html The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 16/36 Gene Ontology BP GO:0002562 0.0839184282471183 0.0949861682962873 3965 3701.27272727273 3728 0.00793650793650794 2791 0.985381549897987 -0.63365473054087 -1 1.19337548660593 3961 2791 2835 3728 4616 3541 3695 4494 3048 3836 4169 4183 M10569 GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 20/50 Gene Ontology BP GO:0090329 0.990862346821046 0.998821944483308 3430 3901 3731 0.34743867117222 3175 0.807878215707367 -0.517174830436356 -1 0.000488243721182339 3427 4493 3175 4418 4332 3611 3622 3662 4525 3915 3731 4184 M14674 GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. 96/234 Gene Ontology BP GO:1901796 0.00012238177194663 0.000217958790620714 4080 3608.90909090909 3735 1.11262345763312e-05 2476 1.23358323416406 -0.95873118046663 -1 5.35082023013727 4076 4148 3078 4133 2476 2814 3735 4576 2961 4050 3651 4185 M11867 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT.html The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. 13/52 Gene Ontology BP GO:0072488 0.514011397665828 0.542522145797326 4295 3482.27272727273 3738 0.0634920634920635 1806 1.09230586904984 0.747810951717757 1 0.343652688564062 4293 2668 1806 3174 4349 3001 3559 3951 4022 3744 3738 4186 M10069 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. 58/140 Gene Ontology BP GO:1903214 0.00534659168384131 0.00734661887779674 4285 3593.54545454545 3740 0.000487239065592704 2082 1.40520629067083 -0.876998782385652 -1 3.55217690799077 4285 4154 3210 4370 3216 2082 3384 3740 3176 3999 3913 4187 M11412 GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. 765/2173 Gene Ontology BP GO:0051172 6.61136698487064e-06 1.75208772321658e-05 3620 3589.45454545455 3740 6.61138665453104e-07 1666 1.43859294090912 1.69503473392751 1 8.10584581235133 3618 4356 3740 4526 1666 3004 3779 3609 2882 3966 4338 4188 M12215 GO_MEMBRANE_TUBULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_TUBULATION.html A modification in a plasma membrane resulting in formation of a tubular invagination. 8/14 Gene Ontology BP GO:0097320 0.0274480393637632 0.0348581090716501 3870 3504.09090909091 3740 0.00277930804780542 1741 0.922390156336588 -0.922390156336588 -1 1.59279292165431 3840 3100 3870 3740 3440 3869 4137 1741 4054 3379 3375 4189 M10441 GO_DENDRITIC_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_MIGRATION.html The movement of a dendritic cell within or between different tissues and organs of the body. 7/48 Gene Ontology BP GO:0036336 0.957121111834927 0.971984541174445 3230 3926.18181818182 3742 0.270165562972015 3228 0.358880806949129 0.580755272823159 1 0.00524477499683138 3228 4642 3585 4530 4229 3631 3447 3487 4464 4203 3742 4190 M16203 GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 14/38 Gene Ontology BP GO:0071549 0.0839184282471183 0.0949861682962873 3210 3477.72727272727 3742 0.00793650793650794 1444 2.31330646448725 1.74982661799792 1 2.80160051832599 3207 4563 1444 3897 3742 3753 3496 3986 3468 2627 4072 4191 M13990 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. 51/106 Gene Ontology BP GO:0042590 0.161385165508919 0.178875942577683 2290 3403.90909090909 3743 0.0158730158730159 1955 1.34120052520117 -0.963498504079228 -1 1.18755087293602 2289 4378 3307 4327 4429 1965 1955 4114 3743 4015 2921 4192 M16295 GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. 14/20 Gene Ontology BP GO:0000028 0.827908611757609 0.849469692205864 4230 3881.72727272727 3743 0.147835264794019 3366 0.410389528650757 -0.410389528650757 -1 0.0344433960603263 4226 3743 3422 3435 4079 3524 3366 4421 4299 4603 3581 4193 M11436 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 9/31 Gene Ontology BP GO:0010804 0.0744048118819056 0.0901047317599603 1910 3208.81818181818 3746 0.00770201646657443 1521 1.34828014132628 -1.34828014132628 -1 1.66947137222746 1906 4134 3746 4162 4608 1521 1936 3909 4033 3484 1858 4194 M13693 GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that activates or increases the frequency, rate or extent of receptor internalization. 8/32 Gene Ontology BP GO:0002092 0.00138556480766887 0.00203646008293972 3000 3467.54545454545 3747 0.000138642947195562 1748 1.64489806686894 1.16927477612162 1 5.24385504218596 4051 3747 4117 3256 2999 4274 4157 2998 2460 1748 4336 4195 M13794 GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. 16/51 Gene Ontology BP GO:0045589 0.0839184282471183 0.0949861682962873 4480 3696.18181818182 3747 0.00793650793650794 2342 1.61105271095166 1.60289912860322 1 1.9511141296399 4480 3740 2342 2973 4254 4323 4063 3747 3433 2853 4450 4196 M11015 GO_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_PROCESSING.html Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. 235/527 Gene Ontology BP GO:0006397 0.161385165508919 0.178875942577683 3330 3820.27272727273 3749 0.0158730158730159 3036 1.04430483130607 -0.833966466893807 -1 0.924667558225956 3326 4520 3497 4481 4318 3036 3552 3904 3749 4173 3467 4197 M16272 GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. 9/30 Gene Ontology BP GO:0032332 0.309801991112757 0.334203216713878 2670 3495.63636363636 3749 0.0363987155919073 2011 0.790776269138314 -0.790776269138314 -1 0.445889606693358 2670 3749 4539 3046 4032 2011 4421 2564 4349 4600 2471 4198 M13667 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. 22/49 Gene Ontology BP GO:0061418 0.0839184282471183 0.0949861682962873 2910 3587.72727272727 3751 0.00793650793650794 2864 1.13796251961897 -0.943139202128758 -1 1.37816344575444 2906 3795 2864 3909 3751 3773 4014 3684 3546 3321 3902 4199 M12920 GO_APOPTOTIC_NUCLEAR_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_NUCLEAR_CHANGES.html Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. 13/32 Gene Ontology BP GO:0030262 0.0115121849230126 0.0151333733288639 3885 3669.27272727273 3752 0.00105207918778294 2836 0.814634757778872 -0.837554011484312 -1 1.75641582808581 3881 3946 2836 4292 3319 3039 2982 4472 4352 3752 3491 4200 M14751 GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. 9/19 Gene Ontology BP GO:0071071 0.251638424434554 0.273491855020982 2170 3286.54545454545 3753 0.0285708126152818 1648 0.795904099778417 -0.795904099778417 -1 0.530870695062526 2167 3891 4286 3753 3948 2147 1648 3168 4276 4499 2369 4201 M15043 GO_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. 346/813 Gene Ontology BP GO:0016071 0.161385165508919 0.178875942577683 4520 3689.27272727273 3753 0.0158730158730159 2274 1.03630475587283 -0.802314918375645 -1 0.917583971663189 2979 4583 3515 4519 4489 2274 2952 3999 3753 4518 3001 4202 M12288 GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING.html Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. 5/11 Gene Ontology BP GO:0006346 0.214139132665174 0.234658483116451 3940 3665 3755 0.0238095238095238 2713 0.957327669993091 -0.957327669993091 -1 0.713965781622231 3940 2713 3884 2966 4042 3471 3744 3672 3800 4328 3755 4203 M12862 GO_PROTEIN_O_LINKED_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_MANNOSYLATION.html The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. 8/16 Gene Ontology BP GO:0035269 0.204869383119057 0.22519141709796 3765 3420.18181818182 3755 0.0226641093165033 2008 0.792164391900919 -0.413279055215559 -1 0.60757125892219 3761 2764 3970 3028 3755 3273 2008 3972 3882 3383 3826 4204 M12989 GO_ORGANELLE_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_FUSION.html The joining of two lipid bilayers to form a single organelle membrane. 51/104 Gene Ontology BP GO:0090174 0.000517727977215078 0.000820693410109119 3325 3636.81818181818 3755 4.70772595237564e-05 2717 1.10646500595988 -1.11942508792698 -1 4.04469762961895 3321 4155 3267 4593 2775 3047 4244 4117 3755 4014 2717 4205 M14606 GO_APOPTOTIC_DNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_DNA_FRAGMENTATION.html The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. 6/18 Gene Ontology BP GO:0006309 0.437610350256457 0.466121783950615 3150 3509 3755 0.0559310112823763 2031 1.2313126854227 -1.2313126854227 -1 0.483536501379822 3147 3927 4256 4081 3908 3011 2031 3755 4144 3149 3190 4206 M16755 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 28/72 Gene Ontology BP GO:0032784 0.706854371424988 0.733391027156697 3755 3703.90909090909 3755 0.105556240425306 2409 0.714790458003241 -0.577531119653884 -1 0.114025836881071 3755 4432 3296 4559 4172 2483 2409 3618 4346 4629 3044 4207 M13289 GO_PROTEIN_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MANNOSYLATION.html The addition of a mannose residue to a protein acceptor molecule. 8/21 Gene Ontology BP GO:0035268 0.204869383119057 0.22519141709796 3765 3424.81818181818 3756 0.0226641093165033 2009 0.792164391900919 -0.413279055215559 -1 0.60757125892219 3762 2765 4045 3029 3756 3274 2009 3934 3883 3389 3827 4208 M13471 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. 17/54 Gene Ontology BP GO:0046641 0.0839184282471183 0.0949861682962873 4270 3516.63636363636 3759 0.00793650793650794 1796 1.71983995064945 1.79183681045135 1 2.08286432130479 4266 3665 2064 3190 4124 3759 4332 4010 3289 1796 4188 4209 M14695 GO_HISTONE_H2A_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_ACETYLATION.html The modification of histone H2A by the addition of an acetyl group. 12/18 Gene Ontology BP GO:0043968 0.161385165508919 0.178875942577683 3410 3797.90909090909 3759 0.0158730158730159 3167 0.961006476837439 -0.498302211905211 -1 0.850911865627923 3408 4200 3167 4456 3989 3381 3834 4250 3759 3704 3629 4210 M14763 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE.html Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. 3/43 Gene Ontology BP GO:0050884 0.0540474435697629 0.0664044139969329 3760 3723.36363636364 3760 0.00554087868617071 2760 0.308538302823512 -0.356192735303762 -1 0.430485141920658 3760 3357 4290 4073 3550 2760 3856 3206 4359 4500 3246 4211 M11527 GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. 3/16 Gene Ontology BP GO:2000400 0.988433703034142 0.996811942745553 3540 3908 3762 0.35979445132097 3331 0.82915100755709 -0.82915100755709 -1 0.00136043822660844 3539 3929 3762 3585 4368 3680 3331 4220 4552 4275 3747 4212 M13400 GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT.html Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. 10/37 Gene Ontology BP GO:0060632 0.913540366827442 0.931189445264504 3465 3845.09090909091 3762 0.199527029553711 3242 0.538262311048561 -0.538262311048561 -1 0.0197407412308929 3461 4168 3242 3549 4381 3258 4255 3762 4486 4406 3328 4213 M12638 GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0034030 0.0733695343182367 0.0889205815295152 2925 3248.54545454545 3764 0.00759108383094559 1277 0.402958704013846 -0.402958704013846 -1 0.501694055233792 2925 4040 3943 3840 3764 1277 1398 3056 4549 4350 2592 4214 M13640 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0034033 0.0733695343182367 0.0889205815295152 2930 3271.81818181818 3765 0.00759108383094559 1278 0.402958704013846 -0.402958704013846 -1 0.501694055233792 2926 4041 4110 3841 3765 1278 1399 3055 4550 4432 2593 4215 M14952 GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0033866 0.0733695343182367 0.0889205815295152 2930 3298.54545454545 3766 0.00759108383094559 1279 0.402958704013846 -0.402958704013846 -1 0.501694055233792 2927 4042 4324 3842 3766 1279 1400 3052 4551 4507 2594 4216 M15017 GO_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location. 977/2309 Gene Ontology BP GO:0008104 7.20033760369248e-06 1.88663473442123e-05 3815 3164.45454545455 3766 7.20036093398659e-07 916 1.40594531673411 -1.18719832237455 -1 7.8683745601347 3813 3756 4334 3766 1686 916 3808 3966 2351 3961 2452 4217 M10088 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR.html Any process that modulates the frequency, rate or extent of double-strand break repair. 17/48 Gene Ontology BP GO:2000779 0.834520592514174 0.855526410033851 3105 3681.27272727273 3767 0.150865036756266 2730 0.569236511420671 0.569236511420671 1 0.0456951840348075 3102 4390 3105 4320 4103 2730 3075 3767 4369 4184 3349 4218 M15870 GO_CELLULAR_MACROMOLECULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULE_LOCALIZATION.html Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 715/1626 Gene Ontology BP GO:0070727 0.000125023211787321 0.000222236895991016 3960 3346.45454545455 3767 1.25030246205891e-05 1314 1.38732639578351 -1.18311029351409 -1 6.00382682569874 3959 3957 4470 3723 2505 1314 3767 3982 2479 3995 2660 4219 M14831 GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of chromosome organization. 82/184 Gene Ontology BP GO:2001252 0.0839184282471183 0.0949861682962873 3880 3516.09090909091 3769 0.00793650793650794 2289 1.61631355610226 -1.35507255577724 -1 1.95748544082342 3878 4414 2668 4372 4246 2289 2789 4102 2852 3769 3298 4220 M11576 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. 8/16 Gene Ontology BP GO:1904406 0.232866712789421 0.253922063757934 3945 3571.18181818182 3771 0.0261611799599658 1928 1.06666718403395 -0.871287411091255 -1 0.752214372365275 3943 3326 3771 3593 3780 3482 1928 4278 4160 2521 4501 4221 M13533 GO_REGULATION_OF_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_DUPLICATION.html Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 20/42 Gene Ontology BP GO:0010824 0.177368664643971 0.196216990693819 2430 3314 3771 0.0175931404451759 1619 0.602237590016592 -0.561131961762008 -1 0.504574956559539 2429 3971 3081 4243 4253 1619 1688 3771 4536 4420 2443 4222 M12072 GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. 20/57 Gene Ontology BP GO:0031057 0.0839184282471183 0.0949861682962873 2840 3651.36363636364 3772 0.00793650793650794 2836 1.27878511939577 1.27878511939577 1 1.54871106294633 2836 4161 3227 4308 3772 3447 3251 3790 3624 3918 3831 4223 M14554 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. 93/194 Gene Ontology BP GO:1901988 0.000761962917481816 0.00116874589556263 2870 3588.18181818182 3772 6.92933589926513e-05 2336 1.4684993113725 -1.3457264976674 -1 5.10102120954752 3487 4180 2894 4041 2870 4264 4409 3772 2336 2867 4350 4224 M11588 GO_CREATINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CREATINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. 4/10 Gene Ontology BP GO:0006600 0.00765367197154732 0.0103062642006654 3995 3434.36363636364 3773 0.00076801608749268 1877 1.01460684671371 -0.775052495160171 -1 2.38809344408264 3994 1877 3773 2003 3279 4411 4268 4410 3171 2775 3817 4225 M10894 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. 29/59 Gene Ontology BP GO:2000378 0.0839184282471183 0.0949861682962873 4555 3645.09090909091 3774 0.00793650793650794 2067 1.50534972193153 -1.38954178803505 -1 1.8230992162949 4552 3736 2067 3844 3867 3847 3899 3774 3408 3346 3756 4226 M10289 GO_NCRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). 9/26 Gene Ontology BP GO:0034661 0.226288078034615 0.247620915935592 3445 3880.72727272727 3775 0.0253292592874631 3334 0.689550038146136 -0.689550038146136 -1 0.495184937225668 3443 4393 3562 4406 3775 3334 3933 3525 4501 4194 3622 4227 M16520 GO_ENDODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the endoderm. 6/16 Gene Ontology BP GO:0001711 0.0201901086423028 0.0259172447957456 3445 3731.54545454545 3775 0.00203759273834 2487 0.646148805014448 0.710439542362749 1 1.21429946745972 3441 2487 4573 3119 3404 4267 2984 3775 4342 4616 4039 4228 M14367 GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING.html The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. 12/28 Gene Ontology BP GO:0051084 0.59553446112803 0.624027646810526 2500 3676.45454545455 3777 0.0789950659805466 2497 0.679513755806274 0.679513755806274 1 0.164851822325321 2497 4100 3020 3777 3973 2843 3525 4123 4537 4471 3575 4229 M13294 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP.html Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. 4/13 Gene Ontology BP GO:0045188 0.000402124529059647 0.000647547167466046 4455 3599.09090909091 3780 4.02197314458826e-05 2749 1.25382639109838 -0.82915100755709 -1 4.73623137238924 4455 3237 4046 2961 2749 3798 4612 2817 3780 2788 4347 4230 M15208 GO__DE_NOVO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_PROTEIN_FOLDING.html The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. 13/33 Gene Ontology BP GO:0006458 0.689601771739754 0.717093174958047 2690 3751.72727272727 3780 0.100894116818666 2686 0.679513755806274 0.679513755806274 1 0.116254742071919 2686 4131 3060 3780 4004 3048 3712 4031 4542 4532 3743 4231 M12164 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 8/16 Gene Ontology BP GO:0045019 0.232866712789421 0.253922063757934 3945 3580.90909090909 3781 0.0261611799599658 1929 1.06666718403395 -0.871287411091255 -1 0.752214372365275 3944 3327 3862 3594 3781 3483 1929 4283 4161 2524 4502 4232 M13094 GO_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. 810/1884 Gene Ontology BP GO:0065003 2.28231644235401e-06 7.83207334948238e-06 4200 3452.90909090909 3782 2.28231878639315e-07 1301 1.50124341771685 -1.27177690627042 -1 9.0807230662522 4196 3782 4010 4150 1301 2543 4105 4201 2217 3720 3757 4233 M14369 GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. 9/19 Gene Ontology BP GO:0036499 0.439989513343317 0.468548465700235 2940 3775.27272727273 3783 0.0563311576008942 2893 0.24240107641597 0.281378140198218 1 0.0945419905219077 2936 4207 4231 3783 3909 3552 3673 2893 4629 4472 3243 4234 M15283 GO_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING.html Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. 52/107 Gene Ontology BP GO:0006342 0.0839184282471183 0.0949861682962873 3590 3779.18181818182 3784 0.00793650793650794 2749 1.26413827436255 -0.917209431428355 -1 1.53097254282419 3589 3784 2749 3779 3887 3719 4046 4530 3517 3857 4114 4235 M15362 GO_NUCLEOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPHAGY.html A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. 14/20 Gene Ontology BP GO:0044804 0.0531811850456149 0.065357396020855 4330 3825.09090909091 3784 0.00495563732753484 3178 1.04024773525975 -1.6987132110291 -1 1.45990533890008 4327 4344 3178 4301 3532 4034 3905 3417 3589 3784 3665 4236 M11663 GO_CYTOKINETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINETIC_PROCESS.html A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). 9/20 Gene Ontology BP GO:0032506 0.958123449888116 0.972633586890847 3750 3877 3785 0.271889842650927 3347 0.682420747501601 -0.682420747501601 -1 0.0097402246058887 3750 3444 3785 4158 4203 3577 3347 3923 4442 4283 3735 4237 M10781 GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. 46/97 Gene Ontology BP GO:0031145 0.97595311629019 0.988298869996805 3040 3882.63636363636 3786 0.287436573734966 3037 0.738222010058104 -0.738222010058104 -1 0.00446855528465573 3037 4480 3417 4379 4470 3317 3472 3786 4561 4220 3570 4238 M13660 GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. 38/88 Gene Ontology BP GO:1901222 4.04527317830226e-06 1.19025369878691e-05 4220 3323.81818181818 3786 3.67752783328189e-07 1483 1.43391997153266 -1.28669939470724 -1 8.36474610719827 4216 3786 2114 2875 1483 3930 4249 4155 2822 2315 4617 4239 M11206 GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. 102/249 Gene Ontology BP GO:0051054 0.0839184282471183 0.0949861682962873 2970 3594.54545454545 3787 0.00793650793650794 2091 1.16787840264001 -1.05358595430006 -1 1.41439401225098 3787 4364 2970 4192 4505 2091 2666 4436 3592 3969 2968 4240 M13765 GO_REGULATION_OF_GROWTH_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. 5/17 Gene Ontology BP GO:0060123 0.000353940359827238 0.000574395348017429 3790 3270.45454545455 3788 3.53996745667465e-05 653 2.05601881677056 -2.05601881677056 -1 7.89325006355844 3788 3847 4131 2645 4385 4061 4370 653 2238 2988 2869 4241 M14809 GO_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 77/173 Gene Ontology BP GO:0071156 1.98144258901948e-05 4.40816384322829e-05 3295 3494.54545454545 3789 1.80132766838234e-06 1968 1.45192271216513 1.39752901130948 1 7.49175692262359 3295 4539 2860 4469 1968 4155 4329 2712 2501 3789 3823 4242 M13141 GO_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 5/19 Gene Ontology BP GO:0070528 0.483371699208695 0.511228883696121 3790 3643 3790 0.0639095398384784 1901 1.98057969718709 -1.98057969718709 -1 0.683653398076119 3790 2714 4019 3300 4570 3769 1901 4382 4047 2985 4596 4243 M10199 GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. 48/104 Gene Ontology BP GO:0006354 0.557443745451391 0.58636413913249 2835 3571.90909090909 3791 0.0714285714285714 2224 0.891142731020876 0.986779168679514 1 0.244735453991287 2832 4379 3466 4583 4340 2431 2224 3791 4074 4104 3067 4244 M14086 GO_DETECTION_OF_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_BIOTIC_STIMULUS.html The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. 24/76 Gene Ontology BP GO:0009595 0.0839184282471183 0.0949861682962873 3795 3714.36363636364 3791 0.00793650793650794 2440 1.60102874414592 -1.39321412789437 -1 1.93897429089073 3792 4290 2440 3718 3981 3340 4151 4329 3580 3446 3791 4245 M12115 GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY.html The formation or destruction of chromatin structures. 96/208 Gene Ontology BP GO:0006333 0.0839184282471183 0.0949861682962873 3955 3542.45454545455 3792 0.00793650793650794 2542 1.38769360676522 -1.02509931613564 -1 1.68060809539903 2542 3275 2586 3951 3792 3505 3952 4194 3317 4021 3832 4246 M11098 GO_RESPONSE_TO_TYPE_I_INTERFERON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TYPE_I_INTERFERON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 50/123 Gene Ontology BP GO:0034340 0.0100116922909177 0.0132736400076331 3770 3791.63636363636 3793 0.000914322326753612 2895 1.25487070154912 1.30038372396688 1 2.79025180525924 3766 3875 2895 4154 3300 4428 3793 4326 3424 3359 4388 4247 M14217 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. 9/16 Gene Ontology BP GO:1904814 0.244302275441861 0.265954388013261 3480 3671.81818181818 3793 0.0276227006655447 2425 0.89556185222811 -0.561262134236352 -1 0.610219331541649 3479 4014 4207 3880 3793 2942 2425 4456 4000 3502 3692 4248 M16625 GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that modulates the frequency, rate or extent of viral release from host cell. 17/50 Gene Ontology BP GO:1902186 0.557443745451391 0.58636413913249 4105 3668.18181818182 3793 0.0714285714285714 2791 0.999700227189814 -0.802214482690516 -1 0.274548916806046 4103 3217 2791 3040 4088 3500 4393 3891 4064 3470 3793 4249 M13603 GO_PARTURITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARTURITION.html The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. 4/26 Gene Ontology BP GO:0007567 0.246089750316114 0.267649264632868 3355 3770 3794 0.0278529452119962 2891 0.584153540353348 -0.661140760122923 -1 0.396121715009866 3351 3956 4102 4164 3794 3173 3781 2891 4341 4424 3493 4250 M13764 GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. 4/27 Gene Ontology BP GO:0060219 0.00224673194570733 0.0032126813747826 3795 3281.81818181818 3794 0.000224900669518067 1041 1.38672851609447 -1.2434177263632 -1 4.09557329616761 3794 1041 4130 1658 3091 4450 4599 4104 3661 1704 3868 4251 M16023 GO_RNA_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_LOCALIZATION.html A process in which RNA is transported to, or maintained in, a specific location. 111/248 Gene Ontology BP GO:0006403 0.415320710913563 0.443499094013724 2645 3656.27272727273 3796 0.0476190476190476 2642 1.13787475360092 -1.2052683388263 -1 0.475967916705228 2642 4601 3482 4439 4506 2898 3796 2754 3950 4145 3006 4252 M15517 GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA.html Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. 13/32 Gene Ontology BP GO:0060330 0.332988546708196 0.358300306457973 3485 3578.36363636364 3799 0.0361440839001605 2365 0.619799275853644 0.674508140203351 1 0.327281181467723 3485 2474 2943 3816 3841 3781 2365 3799 4250 4560 4048 4253 M14352 GO_CYCLOOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLOOXYGENASE_PATHWAY.html The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. 5/22 Gene Ontology BP GO:0019371 0.264779830189614 0.287169528514455 4135 3708.81818181818 3801 0.0302902968565866 2408 1.76665821405798 -1.76665821405798 -1 1.13401397236614 4133 4073 4227 3525 4416 3732 3574 2408 3914 2994 3801 4254 M11768 GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 68/154 Gene Ontology BP GO:0042177 0.0839184282471183 0.0949861682962873 3850 3465.54545454545 3802 0.00793650793650794 1885 1.15658198401482 -0.892391330964419 -1 1.40071313089826 3850 4274 3117 3983 3988 1885 3802 3467 3387 4045 2323 4255 M15563 GO_CAMP_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 3/14 Gene Ontology BP GO:0006198 0.455364038138877 0.483811265235424 3805 3777.36363636364 3802 0.0589544802282288 2370 0.570237537846914 -0.452364901419226 -1 0.21300389018295 3802 3269 4423 3691 3917 3105 2370 4432 4365 4563 3614 4256 M12044 GO_HISTONE_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_EXCHANGE.html The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. 33/164 Gene Ontology BP GO:0043486 0.0839184282471183 0.0949861682962873 3200 3677.54545454545 3803 0.00793650793650794 2244 1.44510469657069 -0.959654545221128 -1 1.75013759266886 3199 3998 2244 4283 3834 3478 3724 4340 3529 3803 4021 4257 M15357 GO_GOLGI_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_VESICLE_TRANSPORT.html The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. 209/431 Gene Ontology BP GO:0048193 2.61693089038707e-05 5.60639366910468e-05 4420 3638 3803 2.37905638151442e-06 2037 1.31100098785446 -1.25573965338977 -1 6.60243963373583 4419 3821 3320 4605 2037 3757 3700 3887 2795 3874 3803 4258 M13418 GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 5/19 Gene Ontology BP GO:0001963 0.147859119791321 0.16482830568814 4225 3541.45454545455 3806 0.0158730158730159 2045 0.431587261984546 -0.521781820512482 -1 0.400303163450027 4221 2045 4072 2728 3905 3699 3955 2382 3734 4409 3806 4259 M13058 GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. 24/62 Gene Ontology BP GO:0032007 0.0839184282471183 0.0949861682962873 3810 3827.90909090909 3807 0.00793650793650794 2852 1.1113353080079 1.1153165199273 1 1.345915727704 3807 4034 2852 3550 4128 4070 3791 4509 3594 3799 3973 4260 M12161 GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 2/10 Gene Ontology BP GO:0046133 0.505759107352892 0.53429796028202 4320 3703.8 3809 0.0753163339749814 2930 0.855847587422836 -0.2164246730063 -1 0.275985525822893 3758 3420 3860 NA 3963 3437 2930 2974 4320 4316 4060 4261 M16096 GO_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING.html The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 204/464 Gene Ontology BP GO:0008380 0.232850105696956 0.253922063757934 3545 3934.45454545455 3809 0.0238095238095238 3353 1.15217781256391 -0.908374697095966 -1 0.812516656469611 3541 4523 3518 4480 4267 3353 3770 4152 3809 4170 3696 4262 M13953 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. 15/41 Gene Ontology BP GO:1904358 0.143235963390569 0.159981856632767 2240 3202.72727272727 3810 0.013955590154527 1213 0.901529632243046 -0.901529632243046 -1 0.850025047352764 2236 4097 2915 3969 4157 1592 1213 4477 4279 3810 2485 4263 M15764 GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. 162/617 Gene Ontology BP GO:0002768 0.0839184282471183 0.0949861682962873 4180 3489.36363636364 3810 0.00793650793650794 2387 1.62763684946664 -1.16429312254914 -1 1.97119886967022 4177 4592 2768 4056 4290 2387 3810 3006 2579 3877 2841 4264 M10886 GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 91/209 Gene Ontology BP GO:0031330 2.57605354512139e-06 8.50683969416687e-06 3955 3587.54545454545 3811 2.34186960137595e-07 1316 1.21237493236112 -1.17281057548154 -1 7.28186729503882 3952 4050 3068 4314 1316 4284 3639 3778 3301 3950 3811 4265 M15433 GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification. 22/71 Gene Ontology BP GO:1903309 0.0839184282471183 0.0949861682962873 2825 3706.18181818182 3811 0.00793650793650794 2823 1.27878511939577 1.27878511939577 1 1.54871106294633 2823 4291 3275 4369 3839 3474 3448 3811 3631 3957 3850 4266 M11336 GO_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION.html The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 23/52 Gene Ontology BP GO:0006306 0.0839184282471183 0.0949861682962873 4545 3849.81818181818 3812 0.00793650793650794 3081 1.46955025147849 -0.643603609497213 -1 1.77974314708318 4541 3765 3093 3812 3819 3694 4391 3590 3081 3963 4599 4267 M14479 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition. 17/33 Gene Ontology BP GO:1902750 0.232850105696956 0.253922063757934 3640 3789.72727272727 3812 0.0238095238095238 2843 1.17791296040814 1.42261883469555 1 0.830665139569889 3638 3549 2843 3711 4015 4596 4399 3867 3812 2909 4348 4268 M16669 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN.html The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. 5/23 Gene Ontology BP GO:0006123 0.057307926922703 0.0701689622104721 3820 3894.09090909091 3813 0.0058841789434644 3457 0.208742996642906 -0.167301020334823 -1 0.285324241794023 3819 3511 4601 3534 3558 3457 3642 4005 4269 4626 3813 4269 M16784 GO_DNA_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_ALKYLATION.html The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. 23/52 Gene Ontology BP GO:0006305 0.0839184282471183 0.0949861682962873 4545 3854 3813 0.00793650793650794 3082 1.46955025147849 -0.643603609497213 -1 1.77974314708318 4542 3766 3094 3813 3820 3695 4392 3625 3082 3965 4600 4270 M16609 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_SNRNP_ASSEMBLY.html The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. 23/45 Gene Ontology BP GO:0000387 0.466815796647786 0.4949590645891 3085 3843.36363636364 3814 0.0555680706492423 3085 0.209150889769998 -0.229824906986751 -1 0.0756729874166151 3085 4128 3418 4325 3906 3201 3649 3814 4517 4622 3612 4271 M11307 GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 16/29 Gene Ontology BP GO:0071480 0.146379288427776 0.163374768310135 4535 3787.45454545455 3817 0.0142850156402679 3038 1.03556815700176 -0.678383091587033 -1 0.965225244561094 4531 3181 3038 3533 3690 4023 4144 3817 3739 3833 4133 4272 M15946 GO_RESPONSE_TO_ETHER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. 8/17 Gene Ontology BP GO:0045472 0.0765897756730953 0.0916038970762961 3820 3643.45454545455 3820 0.00793650793650794 2461 1.74611562115135 -1.01985234737904 -1 2.14725742952605 3820 3415 4483 2869 4516 4213 3602 4091 2461 2544 4064 4273 M15765 GO_VESICLE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING.html The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. 25/63 Gene Ontology BP GO:0048278 0.00357694559870298 0.00500083059764466 4260 3883.54545454545 3821 0.000325706779188278 3154 1.26334693101845 1.41101492066084 1 3.44357212534663 4259 3659 3170 3821 3154 4180 4260 4455 3513 3819 4429 4274 M14373 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 94/240 Gene Ontology BP GO:0043242 0.018054265664568 0.0233108886208536 4035 3667.18181818182 3822 0.00165492296642523 2317 1.73486872359418 -1.55893056233248 -1 3.35491901276648 4032 4051 2317 3772 3375 4631 3257 4166 2626 3822 4290 4275 M15720 GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 6/17 Gene Ontology BP GO:0002283 0.187032155213602 0.206415568494593 4510 4010.54545454545 3822 0.0204934672567717 3563 0.270487954907844 -0.298481671941736 -1 0.219571786199915 4506 3563 4447 3822 3730 3782 3613 3636 4329 4573 4115 4276 M16392 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 3/14 Gene Ontology BP GO:0045086 0.017859609086269 0.0230723886999296 4360 3652.36363636364 3822 0.00180047884732598 2249 1.10391248745813 -0.775052495160171 -1 2.1406049694357 4357 2381 4558 2249 3387 4484 3728 4090 3822 2599 4521 4277 M13046 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 19/36 Gene Ontology BP GO:0006294 0.169374462315772 0.18755202206824 3395 3787.81818181818 3824 0.0167290527813376 2679 0.576585327541034 -0.353288843975212 -1 0.496480151322848 3824 4162 3394 4371 3710 2679 3307 4085 4366 4376 3392 4278 M15080 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes outside the context of DNA replication. 34/63 Gene Ontology BP GO:0006336 0.0839184282471183 0.0949861682962873 2460 3536.09090909091 3826 0.00793650793650794 2222 1.61861941195405 -1.05518540161294 -1 1.96027801972577 2458 3999 2222 4221 4058 3256 3415 4029 3577 3826 3836 4279 M11444 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. 123/266 Gene Ontology BP GO:0048002 0.00156850671567327 0.00229083884267726 4470 3700.90909090909 3827 0.000142693282902556 2582 1.38010108334258 -1.2299191671806 -1 4.31612142938847 4469 3622 2582 4149 3010 3845 4426 3827 3045 3630 4105 4280 M16465 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures, occurring outside the context of DNA replication. 34/63 Gene Ontology BP GO:0034724 0.0839184282471183 0.0949861682962873 2460 3536.63636363636 3828 0.00793650793650794 2223 1.61861941195405 -1.05518540161294 -1 1.96027801972577 2459 4000 2223 4222 4059 3257 3416 4024 3578 3828 3837 4281 M10085 GO_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. 27/70 Gene Ontology BP GO:0002181 0.314560544536362 0.339100210885147 2705 3446.45454545455 3829 0.0337531302681681 1579 0.60020411301314 -0.60020411301314 -1 0.333940810120262 2705 4336 3389 4468 4488 2192 1579 3829 4305 4183 2437 4282 M12430 GO_DNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_MODIFICATION.html The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. 35/83 Gene Ontology BP GO:0006304 0.0839184282471183 0.0949861682962873 3930 3669 3829 0.00793650793650794 2924 1.30581474693692 -0.700605150768877 -1 1.58144613940447 3927 3829 3261 4107 3885 3125 4012 2924 3511 4053 3725 4283 M14850 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 443/1011 Gene Ontology BP GO:0080135 4.46110878760112e-07 2.74343418554066e-06 4220 3446.63636363636 3831 4.05555426564966e-08 603 1.352204723964 -1.12615320908415 -1 8.90898963276017 4219 4177 2892 3792 603 2711 4515 4038 3055 3831 4080 4284 M11946 GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. 6/11 Gene Ontology BP GO:0033262 0.370290289893548 0.397332520447364 2810 3485.36363636364 3832 0.0451964193234622 2037 0.244810635443417 -0.285803415831169 -1 0.116246405449042 2809 4453 3832 4488 4556 2037 2118 2562 4606 4302 2576 4285 M16064 GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. 10/29 Gene Ontology BP GO:0045346 0.823320937457184 0.845164517491423 4200 3816 3832 0.145794662934457 2897 0.74102472534625 -0.74102472534625 -1 0.064131532084674 4197 3638 2897 3014 4219 3832 4306 3146 4417 4589 3721 4286 M13031 GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. 16/36 Gene Ontology BP GO:0014742 0.390698408340061 0.418360864834617 3055 3445.09090909091 3835 0.0440409232432786 1714 1.0217233657078 -1.4173544028524 -1 0.458054479594341 3053 4388 2815 4117 4072 2409 1714 3847 4184 3835 3462 4287 M14613 GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. 4/13 Gene Ontology BP GO:0048484 0.000294808163963795 0.000486077523183202 4195 3292.27272727273 3835 2.94847281601811e-05 620 1.13580257730489 -0.741565848784047 -1 4.45800778028027 4195 620 4257 1407 2688 4642 3684 3874 3835 2792 4221 4288 M12598 GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 13/35 Gene Ontology BP GO:0033146 0.850621352955467 0.871262947666497 4370 3849.90909090909 3837 0.158730158730159 3012 0.742710835397354 0.60664725218827 1 0.052656698236821 4369 3837 3047 3770 4113 3012 4498 4270 4271 3750 3412 4289 M15372 GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle phase transition. 209/442 Gene Ontology BP GO:1901987 0.0450812425942159 0.0558463738967301 4315 3850.27272727273 3837 0.00418476598885573 2961 1.26050987912537 -1.16446691179839 -1 1.87101287550025 4313 4521 3401 4276 3509 2961 3837 4595 3434 3985 3521 4290 M15139 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY.html Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. 16/36 Gene Ontology BP GO:0010613 0.390698408340061 0.418360864834617 3055 3450.81818181818 3839 0.0440409232432786 1715 1.0217233657078 -1.4173544028524 -1 0.458054479594341 3054 4389 2816 4118 4073 2410 1715 3897 4185 3839 3463 4291 M16076 GO_POSITIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the cell cycle. 202/497 Gene Ontology BP GO:0045787 1.73713307167445e-06 6.43227941495494e-06 4380 3550.54545454545 3839 1.57921313029688e-07 1163 1.47068268661463 1.4455740715692 1 9.04484566045302 4377 4587 2690 3918 1163 3240 4480 3861 3136 3765 3839 4292 M16840 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. 31/108 Gene Ontology BP GO:0046635 0.0839184282471183 0.0949861682962873 4605 3642.36363636364 3839 0.00793650793650794 2165 1.53224793986969 1.55136228643796 1 1.85567514504024 4601 3966 2282 3839 3762 3892 4369 3687 3360 2165 4143 4293 M15301 GO_MITOCHONDRION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_MORPHOGENESIS.html The process in which the anatomical structures of a mitochondrion are generated and organized. 16/37 Gene Ontology BP GO:0070584 0.0256449959605282 0.0326307800067778 4105 3132.09090909091 3841 0.00235899148812413 404 3.41066745082706 -0.812330556144775 -1 6.00544275249175 4101 4441 2468 4234 4568 2456 2496 1554 404 3841 3890 4294 M16333 GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. 20/61 Gene Ontology BP GO:0046640 0.0839184282471183 0.0949861682962873 3845 3592.63636363636 3841 0.00793650793650794 2142 1.57752653124315 1.56036746639143 1 1.9105112003381 3841 3715 2224 3327 4048 4634 3906 3846 3302 2142 4534 4295 M13097 GO_PROTEIN_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_STABILIZATION.html Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. 83/182 Gene Ontology BP GO:0050821 0.0839184282471183 0.0949861682962873 4125 3632.72727272727 3843 0.00793650793650794 2035 1.23775431844601 -1.2884684895288 -1 1.49901942719648 4124 4472 3045 4238 4557 2035 4444 3843 3440 3627 2135 4296 M14195 GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT.html The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. 5/12 Gene Ontology BP GO:0043369 0.0765897756730953 0.0916038970762961 3270 3641.18181818182 3846 0.00793650793650794 2890 1.09979387731524 -0.810439928653025 -1 1.3524531013094 4074 3267 4201 3269 4156 3846 3234 4116 2890 2993 4007 4297 M13909 GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. 5/31 Gene Ontology BP GO:0045624 2.90512836780566e-05 6.10339864783786e-05 4495 3026.90909090909 3847 2.90516634747321e-06 488 1.74908577857432 -1.78437778054164 -1 8.7322828059084 4494 488 4154 1549 2122 4196 3847 4607 2733 1093 4013 4298 M16832 GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 12/26 Gene Ontology BP GO:0043518 0.00136474668854669 0.0020084053486283 4465 3850.45454545455 3848 0.00012414491188008 2977 0.807585301641838 -0.807585301641838 -1 2.58030535822659 4464 3808 3138 3045 2977 4091 3641 4398 4311 4634 3848 4299 M10990 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. 4/12 Gene Ontology BP GO:0090220 0.946603210708112 0.962355749357951 3145 3807.72727272727 3849 0.253978206982114 2929 0.268804049304272 0.287695076573396 1 0.00530474791442194 3142 3849 3668 4213 4372 3247 2929 4223 4483 4234 3525 4300 M11148 GO_OXIDATIVE_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. 5/41 Gene Ontology BP GO:0070989 0.197082854376083 0.217146581126756 3850 3754.18181818182 3849 0.0217112187095491 2268 1.08861813587471 -1.08861813587471 -1 0.85531898089346 3849 4072 3699 3755 4617 4097 3923 2268 4246 2974 3796 4301 M11322 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_ELONGATION.html Any process that modulates the frequency, rate, extent or accuracy of translational elongation. 16/25 Gene Ontology BP GO:0006448 0.745976056196239 0.772772607969464 3270 3797.45454545455 3851 0.117128096933778 2290 0.567798914744984 -0.567798914744984 -1 0.0752974705766528 3269 4564 3386 4319 4486 3229 2290 3851 4457 4261 3660 4302 M16622 GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE.html Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. 20/40 Gene Ontology BP GO:0043094 6.44647672980625e-06 1.72215140716286e-05 4050 3435.90909090909 3851 5.86045056314317e-07 1000 0.840765012188216 0.856606370047978 1 4.74479909733775 4047 1000 2588 3851 1633 4408 3614 4515 3905 3677 4557 4303 M11699 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT.html Any process that modulates the frequency, rate or extent of cellular response to heat. 53/95 Gene Ontology BP GO:1900034 0.0839184282471183 0.0949861682962873 2395 3600.72727272727 3852 0.00793650793650794 2391 1.28893219234911 -1.49028197305118 -1 1.56099999324876 2391 4120 3194 4129 3852 3198 2555 4603 3574 4026 3966 4304 M15704 GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. 148/343 Gene Ontology BP GO:0043123 9.59696214038905e-06 2.38792578873668e-05 4400 3532.63636363636 3852 8.72454909549617e-07 1749 1.31989788925831 -1.27036472785016 -1 7.2268047152294 3887 3852 2963 3579 1749 3874 4400 3932 3156 3071 4396 4305 M16750 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. 20/47 Gene Ontology BP GO:0002483 0.0839184282471183 0.0949861682962873 4070 3445.36363636364 3852 0.00793650793650794 2257 2.13373355852299 -1.32892068495983 -1 2.58412312994537 4067 3909 2257 2929 4028 3287 3852 3970 2911 2653 4036 4306 M11686 GO_REGULATION_OF_PROTEIN_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_GLYCOSYLATION.html Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. 5/16 Gene Ontology BP GO:0060049 0.0566840345535114 0.0694416813804626 4300 3794.45454545455 3854 0.00581840596665753 2968 1.00601323991843 -1.00601323991843 -1 1.38048672331407 4299 2968 3790 3259 3557 3854 4376 4601 4200 2978 3857 4307 M16541 GO_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION.html The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. 124/248 Gene Ontology BP GO:0006260 0.984221615637584 0.994467127727277 2310 3787.63636363636 3856 0.314215756102954 2309 0.736452176319601 -0.671853943288901 -1 0.002100459225244 2309 4325 3461 4440 4230 3365 3333 3856 4472 4162 3711 4308 M13750 GO_GLYCINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycine, aminoethanoic acid. 6/20 Gene Ontology BP GO:0006544 0.376016476402427 0.403383664495488 3860 3834.09090909091 3859 0.0460682314667408 2559 1.39860050209259 1.39860050209259 1 0.653246777735021 3859 3846 4128 3508 4163 4617 4440 2559 4115 3140 3800 4309 M10478 GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of cholesterol homeostasis. 6/18 Gene Ontology BP GO:2000188 0.214139132665174 0.234658483116451 4635 3586.72727272727 3860 0.0238095238095238 2076 1.14858422717504 -1.2434177263632 -1 0.856603421023686 4633 2076 3594 2217 4394 3894 4452 3860 3764 2169 4401 4310 M15886 GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. 9/26 Gene Ontology BP GO:0042762 0.265891481541368 0.288240520382109 3875 3779.63636363636 3864 0.0304370166156046 2962 1.54539616595905 1.54539616595905 1 0.989026488322265 3874 3127 4474 3124 3813 4372 2962 3864 4088 3512 4366 4311 M15127 GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that activates or increases the frequency, rate or extent of DNA recombination. 5/22 Gene Ontology BP GO:0045911 0.0213742500247134 0.0273918418064434 3860 3947.63636363636 3867 0.00215826632646858 3410 0.809494824895457 -0.809494824895457 -1 1.49822837693072 3858 3510 4357 3867 3410 3618 4317 4086 4175 4524 3702 4312 M13340 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 151/356 Gene Ontology BP GO:0090068 7.13529940105289e-07 3.52813579543009e-06 3550 3378.54545454545 3868 6.48663792296216e-08 814 1.66159602922209 1.58371585152617 1 10.7323677594223 3547 4524 1969 4033 814 4170 3868 4323 2808 2614 4494 4313 M15645 GO_PROTEIN_K48_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. 28/61 Gene Ontology BP GO:0070936 0.700539382714199 0.727163951250173 3805 3776.72727272727 3868 0.10382150218831 2965 0.840302437494883 -0.949633733039423 -1 0.137734588582376 3805 4059 3146 4235 4549 3868 3132 2965 4263 4010 3512 4314 M15823 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein. 7/25 Gene Ontology BP GO:0042523 0.0834917224170634 0.0949861682962873 3595 3796.18181818182 3869 0.00868052280352473 2883 1.17140751881127 -1.5881758638962 -1 1.41866805885115 3595 2934 4463 2883 3612 4601 4620 3869 3926 3300 3955 4315 M13456 GO_DNA_REPLICATION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INITIATION.html The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. 15/31 Gene Ontology BP GO:0006270 0.9933992505259 0.999859683544712 2645 3786.54545454545 3875 0.36644954883193 2641 0.254947526671515 -0.296646185149469 -1 1.67239636557546e-05 2641 4011 3015 3848 4331 3458 3571 3875 4593 4412 3897 4316 M13231 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. 12/36 Gene Ontology BP GO:2000142 0.203651919723792 0.224118479089255 4395 3859.18181818182 3876 0.0204889088243064 3195 0.605788875727792 0.605788875727792 1 0.46611375306139 4395 3690 3262 3961 3729 3195 3934 3826 4190 4393 3876 4317 M13768 GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 40/88 Gene Ontology BP GO:0072527 0.0094301106060611 0.0125635591230823 4265 3746.45454545455 3876 0.000860979655185663 2761 1.49327972427096 -0.735910223931362 -1 3.36260167258905 4265 3876 2761 4079 3291 3422 3739 4485 3022 3925 4346 4318 M10234 GO_NUCLEOTIDE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. 28/76 Gene Ontology BP GO:0046939 0.0839184282471183 0.0949861682962873 4195 3808.54545454545 3878 0.00793650793650794 2927 1.27178385526816 -1.07208238357039 -1 1.54023196288578 4194 3682 2927 3749 3937 3563 4323 4495 3194 3878 3952 4319 M10723 GO_MEMBRANE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DISASSEMBLY.html The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. 28/57 Gene Ontology BP GO:0030397 0.0839184282471183 0.0949861682962873 3370 3719.63636363636 3880 0.00793650793650794 2799 1.69595629670256 -1.69595629670256 -1 2.05393927463661 3370 4383 3022 4414 4064 3939 3972 2799 3550 3880 3523 4320 M15873 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. 39/96 Gene Ontology BP GO:2001022 0.000286975603717423 0.000474173568704624 4180 3790 3880 2.60920949676999e-05 2667 1.03534643123628 -0.620686611611616 -1 4.07692587109003 4178 3827 3024 4027 2667 3880 4475 3484 3593 3910 4625 4321 M16773 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. 2/23 Gene Ontology BP GO:0014857 0.107493019657188 0.120874325567528 3925 3695.4 3880.5 0.0125561656893461 1958 0.634773108740861 -0.597149046337573 -1 0.690049386930954 3925 1958 4617 NA 3670 3917 3011 3138 3844 4631 4243 4322 M15629 GO_NUCLEAR_ENVELOPE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_DISASSEMBLY.html The controlled breakdown of the nuclear envelope in the context of a normal process. 28/57 Gene Ontology BP GO:0051081 0.0839184282471183 0.0949861682962873 3375 3718.45454545455 3883 0.00793650793650794 2774 1.69595629670256 -1.69595629670256 -1 2.05393927463661 3371 4384 3023 4415 4065 3940 3973 2774 3551 3883 3524 4323 M15577 GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. 151/364 Gene Ontology BP GO:0006091 0.0839184282471183 0.0949861682962873 4040 3861.63636363636 3884 0.00793650793650794 3239 1.35446065179476 -0.952550682664955 -1 1.64036028509413 4336 4270 3392 4331 3725 3519 3708 4037 3239 4037 3884 4324 M13286 GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 48/104 Gene Ontology BP GO:0042158 0.000516128794137667 0.000818717455135356 4475 3819.27272727273 3888 4.69318108909972e-05 2774 1.01727918436338 1.28393112730811 1 3.71993913121109 4473 3825 3284 4396 2774 3462 3888 4068 3372 3914 4556 4325 M15375 GO_PROTEIN_K63_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. 18/32 Gene Ontology BP GO:0070536 0.893215540397245 0.912274472957415 3790 3919.18181818182 3888 0.184014295318153 2787 0.983865201326097 -0.983865201326097 -1 0.0464721739207605 3786 4495 3157 4532 4629 3518 2787 3251 4521 4547 3888 4326 M11352 GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. 9/12 Gene Ontology BP GO:0051103 0.564899131345693 0.593533982086005 3895 3940.72727272727 3891 0.0798492275614162 3157 0.654162550255648 -0.654162550255648 -1 0.175562655665604 3891 3157 3734 3814 3976 3856 4582 4341 4283 4264 3450 4327 M13659 GO_TRNA_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_TRANSPORT.html The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 18/40 Gene Ontology BP GO:0051031 0.0839184282471183 0.0949861682962873 3560 3884.90909090909 3891 0.00793650793650794 2896 1.54668507782595 -1.54668507782595 -1 1.87315969284303 3557 4560 3046 4555 4425 4172 4437 2896 3527 3891 3668 4328 M12337 GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS.html The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. 113/269 Gene Ontology BP GO:0015980 0.0839184282471183 0.0949861682962873 4050 3787.09090909091 3892 0.00793650793650794 3231 1.34276054227151 -0.864249045669888 -1 1.62619050124384 4049 4145 3444 4268 3823 3314 3244 4200 3231 4048 3892 4329 M12348 GO_ERROR_FREE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_FREE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. 9/26 Gene Ontology BP GO:0070987 0.947921259863782 0.963484765662772 3495 3948.90909090909 3893 0.255840471592183 3100 0.140084468116398 -0.167473637097597 -1 0.0026792084538623 3495 4567 3893 4465 4186 3305 3100 3739 4637 4331 3720 4330 M12355 GO_ATRIAL_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_DEVELOPMENT.html The progression of the atrial septum over time, from its initial formation to the mature structure. 9/26 Gene Ontology BP GO:0003283 0.121343217849886 0.136086125719088 3360 3704.63636363636 3895 0.0128527805431395 2680 1.47578857662426 -1.29214926568553 -1 1.51430375357245 3359 4135 3895 4095 3674 3586 2954 4419 4009 2680 3945 4331 M16224 GO_TRANSCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCYTOSIS.html The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. 6/12 Gene Ontology BP GO:0045056 0.147859119791321 0.16482830568814 4305 3905.63636363636 3895 0.0158730158730159 2970 1.28897958330944 -1.82331999289253 -1 1.19554975824533 4301 3164 4530 3559 3895 4635 4513 2970 3657 3158 4580 4332 M13712 GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT.html A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. 59/132 Gene Ontology BP GO:0044774 0.0838012157791116 0.0949861682962873 4300 3746.36363636364 3896 0.0079249691220615 2309 1.8349766669996 -1.52389409907288 -1 2.22230424540745 4300 4423 2726 4533 3600 3339 3896 4539 2309 3520 4025 4333 M11049 GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. 77/173 Gene Ontology BP GO:0045931 0.0839184282471183 0.0949861682962873 4515 3790.90909090909 3897 0.00793650793650794 2653 1.26498204502773 -1.28556258544763 -1 1.53199441769817 4512 4604 2653 4467 3941 3897 3925 3223 3612 3437 3429 4334 M10297 GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. 10/17 Gene Ontology BP GO:1904872 0.898024085733636 0.916782284534141 3135 3678.54545454545 3902 0.187425070429507 2642 0.561262134236352 -0.561262134236352 -1 0.0250867920882878 3135 3981 3103 3902 4324 3211 2642 4179 4350 4195 3442 4335 M12626 GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that reduces the force with which blood travels through the systemic arterial circulatory system. 6/15 Gene Ontology BP GO:0003085 0.433446594863611 0.46203171754152 3650 3732.27272727273 3903 0.0552343702428842 3127 1.0818214294583 1.0818214294583 1 0.429736332116197 3646 3233 3940 3406 3903 4049 3949 4165 4043 3127 3594 4336 M14404 GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. 10/17 Gene Ontology BP GO:1904874 0.898024085733636 0.916782284534141 3140 3705.36363636364 3903 0.187425070429507 2643 0.561262134236352 -0.561262134236352 -1 0.0250867920882878 3136 3982 3104 3903 4325 3212 2643 4183 4351 4477 3443 4337 M12341 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 13/19 Gene Ontology BP GO:0033160 0.556695792679059 0.58636413913249 3395 3681 3904 0.0712860123355915 2753 1.67850177463967 1.67850177463967 1 0.460970171972093 3391 4446 2832 3982 4220 4115 2819 2753 4280 3749 3904 4338 M13627 GO_ORGAN_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_INDUCTION.html The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. 5/25 Gene Ontology BP GO:0001759 0.210202063845054 0.230670806530982 2375 3401.63636363636 3904 0.0233215631462555 1397 0.23798161565714 0.288454795326283 1 0.179581625159946 2371 4314 4108 3904 4146 2271 1397 3096 4608 4430 2773 4339 M15253 GO_VIRAL_LATENCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LATENCY.html The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. 5/16 Gene Ontology BP GO:0019042 0.214139132665174 0.234658483116451 3905 3839.54545454545 3905 0.0238095238095238 3054 0.27309585765708 0.153558225948074 1 0.203671065702293 3905 3054 4376 3576 3939 3666 3388 4022 3806 4538 3965 4340 M12437 GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of granulocyte differentiation. 7/21 Gene Ontology BP GO:0030852 0.0146162659768929 0.0190359952119814 4090 3858.09090909091 3908 0.00147133012966383 3277 1.01157760117376 -1.01157760117376 -1 2.06163865487022 4089 4139 3908 4161 3359 3924 4491 3711 3695 3277 3685 4341 M16744 GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION.html A cellular localization which involves only one organism. 533/1309 Gene Ontology BP GO:1902580 2.99656432524015e-05 6.24743967763359e-05 3585 3547.81818181818 3908 2.99660473329692e-06 2132 1.51601123861773 1.8228390295932 1 7.55046866546561 3585 4512 4615 3987 2132 2882 4262 2801 2295 3908 4047 4342 M14247 GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 9/27 Gene Ontology BP GO:0071360 0.0187874596059425 0.024203711140508 4345 3755.63636363636 3909 0.00189482115635743 2692 1.02934146793114 -0.815298836937046 -1 1.97065354046172 4342 3531 4213 2735 3395 4439 4636 4076 3344 2692 3909 4343 M10612 GO_CELLULAR_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 56/108 Gene Ontology BP GO:0034644 0.0356302487231267 0.0446508083188872 3985 3601.18181818182 3913 0.00329279395979113 2191 1.45858237616856 -0.79607943990626 -1 2.33290697357515 3983 4085 2356 3980 3471 3913 4462 2191 3033 3632 4507 4344 M14906 GO_URATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. 6/18 Gene Ontology BP GO:0046415 0.562604368603265 0.591256696112486 3990 3838.36363636364 3914 0.0793650793650794 2661 0.70279922619609 0.70279922619609 1 0.190005734187429 3989 3387 4314 3220 4524 3810 2661 3914 4086 4505 3812 4345 M10774 GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 20/30 Gene Ontology BP GO:0033158 0.481904588752678 0.509793348274933 3275 3709.45454545455 3916 0.05802961375569 2651 1.67850177463967 1.67850177463967 1 0.581810606333437 3273 4627 3075 3849 4148 3966 3050 2651 4323 3916 3926 4346 M16423 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 5/33 Gene Ontology BP GO:0090208 0.258944096344889 0.281037269595446 3920 3752.81818181818 3916 0.0295233353212872 1998 1.05375072798688 1.05375072798688 1 0.688101596678197 3916 1998 4563 3066 3807 4373 4524 3374 4199 3007 4454 4347 M12048 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION.html The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. 15/30 Gene Ontology BP GO:0000715 0.941049302187759 0.957757981161281 4165 3887.63636363636 3917 0.226916742037053 3053 0.353288843975212 -0.353288843975212 -1 0.00784300137533689 3575 4164 3383 3917 4571 3053 3225 4163 4610 4309 3794 4348 M12918 GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. 41/90 Gene Ontology BP GO:0006368 0.35943518917414 0.38613086148439 3625 3907.18181818182 3917 0.0396825396825397 2969 0.946610783347825 0.986779168679514 1 0.463422493503631 3622 4616 3453 4564 4358 3232 2969 4545 3917 4080 3623 4349 M12928 GO_PARENTAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARENTAL_BEHAVIOR.html A reproductive behavior in which a parent cares for and rears offspring. 4/16 Gene Ontology BP GO:0060746 0.000135062248026363 0.000238257605465959 4565 3271.18181818182 3917 1.35070457543488e-05 705 2.86116075408543 -2.49872111272945 -1 12.2795663129101 4564 3055 3981 2199 2524 4516 4326 4496 705 1700 3917 4350 M12389 GO_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE.html Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. 468/1049 Gene Ontology BP GO:0000278 0.0839184282471183 0.0949861682962873 3920 3955.09090909091 3918 0.00793650793650794 3405 1.34095380051438 -1.03221343767732 -1 1.62400239008804 3872 4580 3470 4444 3918 3405 3918 4295 3498 4174 3932 4351 M13927 GO_MATERNAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_BEHAVIOR.html Female behaviors associated with the care and rearing of offspring. 4/16 Gene Ontology BP GO:0042711 0.000135062248026363 0.000238257605465959 4565 3288.63636363636 3918 1.35070457543488e-05 706 2.86116075408543 -2.49872111272945 -1 12.2795663129101 4565 3056 4158 2200 2525 4517 4327 4498 706 1705 3918 4352 M12504 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY.html The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. 8/14 Gene Ontology BP GO:0000244 0.783552015577743 0.808451557406102 3670 3800.81818181818 3920 0.14190503320729 2944 0.172859046683135 -0.253287715267045 -1 0.0189081774301668 3668 4110 3920 4112 4070 2944 3458 3162 4540 4344 3481 4353 M13885 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE.html A process of chromosome organization that is involved in a meiotic cell cycle. 20/56 Gene Ontology BP GO:0070192 0.775485941583084 0.800484932585651 2300 3610.90909090909 3921 0.126984126984127 2300 0.892464331775903 0.888727210494804 1 0.10217613553963 2300 4130 3090 4232 4193 2879 2566 4592 4218 3921 3599 4354 M14343 GO_CELLULAR_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 32/117 Gene Ontology BP GO:0071398 0.00158016852258885 0.00230714542464781 3445 3649.09090909091 3921 0.000143754966775383 1648 1.21314945316975 1.06546319679135 1 3.78957056444358 3445 3428 1648 4296 3012 4361 4146 3921 4055 3527 4301 4355 M12475 GO_LONG_TERM_SYNAPTIC_DEPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_DEPRESSION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. 7/24 Gene Ontology BP GO:0060292 0.0185025176780538 0.0238631082164455 4165 3819.54545454545 3922 0.00186584019212657 3163 0.732213695236796 0.732213695236796 1 1.40714667078777 3605 3922 3915 4021 3392 4165 3163 3299 4027 4343 4163 4356 M15475 GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the C-terminal amino acid residue in a protein. 8/16 Gene Ontology BP GO:0018410 0.773634170799829 0.799106441607031 2925 3765.81818181818 3922 0.138051959100441 2416 0.427593319650091 0.427593319650091 1 0.0493324305760403 2922 4172 4413 3663 4417 3178 2416 3922 4394 4557 3370 4357 M16110 GO_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_PROLIFERATION.html The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. 16/52 Gene Ontology BP GO:0007405 0.0289691743009535 0.03669955696571 3435 3880 3922 0.0026688925976757 2998 1.13792079932175 1.17818953803905 1 1.93483662303125 4073 3716 2998 4280 3433 4234 4643 4392 3557 3432 3922 4358 M10434 GO_MRNA_SPLICE_SITE_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_SPLICE_SITE_SELECTION.html Selection of a splice site by components of the assembling spliceosome. 15/42 Gene Ontology BP GO:0006376 0.891073518496821 0.910687727576654 3925 3957.09090909091 3923 0.182539682539683 2646 1.34828014132628 -1.34828014132628 -1 0.064893219631107 3923 4496 3208 4531 4603 3864 2646 3651 4296 3806 4504 4359 M11186 GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. 7/23 Gene Ontology BP GO:0031645 0.0765897756730953 0.0916038970762961 4185 3815.45454545455 3925 0.00793650793650794 3112 3.22360039544141 3.22360039544141 1 3.96417184510806 4182 3508 3703 3925 4283 4251 3326 4300 3112 3273 4107 4360 M14168 GO_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING.html Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. 113/252 Gene Ontology BP GO:0016458 0.0839184282471183 0.0949861682962873 3500 3892.09090909091 3927 0.00793650793650794 3340 1.3377312932265 -0.986484464117815 -1 1.62009967177293 3496 4468 3340 4330 3686 3530 4142 4309 3508 4077 3927 4361 M15403 GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. 8/17 Gene Ontology BP GO:0033235 0.275742742869669 0.298571258195865 3705 3922.63636363636 3927 0.0317460317460317 3279 0.776781783799484 0.776781783799484 1 0.483053483371861 3703 3381 4398 3927 3950 4077 4296 3279 3863 4548 3727 4362 M14580 GO_REGULATION_OF_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_FUSION.html Any process that modulates the frequency, rate or extent of myoblast fusion. 6/24 Gene Ontology BP GO:1901739 0.386086746459241 0.413613466499828 3660 3679.09090909091 3930 0.0476190476190476 2191 1.33825259577136 -1.02563640966284 -1 0.607817416608867 3656 2527 4252 3073 4225 4243 3785 4312 3930 2191 4276 4363 M15036 GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. 3/16 Gene Ontology BP GO:0033089 0.988433703034142 0.996811942745553 3540 3983 3930 0.35979445132097 3332 0.82915100755709 -0.82915100755709 -1 0.00136043822660844 3540 3930 4337 3586 4369 3681 3332 4221 4553 4516 3748 4364 M15714 GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 127/307 Gene Ontology BP GO:0043244 0.0839184282471183 0.0949861682962873 3830 3852 3932 0.00793650793650794 2642 1.53465150379248 -1.27033303494058 -1 1.85858605636023 3828 4324 2642 3843 4395 4575 3261 4234 2841 3932 4497 4365 M13573 GO_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 90/182 Gene Ontology BP GO:0009411 0.000613415762545319 0.000960245915542116 4405 3611.54545454545 3933 5.57806241093195e-05 2134 1.21042606062439 1.59105842701348 1 4.32693521306722 4046 4149 2824 4262 2805 3542 4404 2134 3226 3933 4402 4366 M15019 GO_NUCLEAR_ENVELOPE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. 50/100 Gene Ontology BP GO:0006998 0.00453991503007895 0.00628843242382356 3940 3767.36363636364 3936 0.000413573704024865 3163 1.59533987831282 -1.24786543189947 -1 4.16046117054626 4150 4278 3201 4229 3186 3567 3939 3535 3163 3936 4257 4367 M16675 GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 95/214 Gene Ontology BP GO:0035966 0.0839184282471183 0.0949861682962873 3440 3909 3939 0.00793650793650794 3414 0.963144042744985 0.961547683362865 1 1.16644405753671 3440 3854 3414 4124 4244 4376 3485 3939 3595 4044 4484 4368 M13249 GO_DNA_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEMETHYLATION.html The removal of a methyl group from one or more nucleotides within an DNA molecule. 3/14 Gene Ontology BP GO:0080111 0.251493687271207 0.27339854600801 3165 3618.09090909091 3940 0.028552026286034 1485 0.140324422872217 0.140324422872217 1 0.0936201086908943 3161 4023 4037 3834 4496 2401 1485 3940 4628 4395 3399 4369 M14406 GO_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_GENE_SILENCING.html The inactivation of gene expression by a posttranscriptional mechanism. 21/58 Gene Ontology BP GO:0016441 0.775485941583084 0.800484932585651 4305 3955.45454545455 3940 0.126984126984127 3295 1.00829358059891 -0.728664828899404 -1 0.115437371198952 4304 4003 3295 3614 4448 3748 4490 3673 4216 3940 3779 4370 M10661 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. 6/23 Gene Ontology BP GO:0051818 0.386086746459241 0.413613466499828 3745 3962.18181818182 3942 0.0476190476190476 2937 0.949770503685069 -0.949770503685069 -1 0.431373271698934 4475 2937 3615 3742 3942 4200 4533 3744 3940 4212 4244 4371 M12633 GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 7/15 Gene Ontology BP GO:0006244 0.815467826685497 0.838214992096693 3845 3876.63636363636 3942 0.155485307451452 3163 0.431271265300111 -0.431271265300111 -1 0.0391553758068408 3844 4019 3942 4165 4563 3163 3453 3433 4538 4349 3174 4372 M14852 GO_MISMATCH_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR.html A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. 18/34 Gene Ontology BP GO:0006298 0.0839184282471183 0.0949861682962873 3905 3581.90909090909 3942 0.00793650793650794 677 3.13494823348846 -0.71112730430769 -1 3.79667549997374 3903 3942 2477 4460 4588 4492 4087 2508 677 3893 4374 4373 M12650 GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. 8/11 Gene Ontology BP GO:0070129 0.397672600565329 0.425632522919508 3945 3603 3944 0.0494318427228694 2591 0.588837072198785 -0.588837072198785 -1 0.258763840495481 3385 4070 3945 3944 4261 2701 3174 2591 4288 4351 2923 4374 M16083 GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI.html The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. 10/21 Gene Ontology BP GO:0000301 0.000423363198077906 0.000678989750837899 3665 3734.81818181818 3945 3.84949719203454e-05 2741 0.549975587225531 -0.549975587225531 -1 2.06407314529616 3665 3557 2949 4008 2741 4067 4060 3945 4481 4590 3020 4375 M12679 GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary amino compound. 6/25 Gene Ontology BP GO:1901160 0.0765897756730953 0.0916038970762961 3180 3520.36363636364 3946 0.00793650793650794 2238 3.06908479856712 3.06908479856712 1 3.77415864139972 3177 4352 3946 4146 4471 3970 4096 2238 2247 3128 2953 4376 M16882 GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. 9/22 Gene Ontology BP GO:0000737 0.632427457617131 0.661193579310141 3890 3973.18181818182 3948 0.0952380952380952 3352 1.2313126854227 -1.2313126854227 -1 0.262073165045271 3888 4256 4631 4360 4198 3720 3352 3948 4149 3519 3684 4377 M13570 GO_TRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. 13/23 Gene Ontology BP GO:0030488 0.556019442755542 0.585794933676873 3895 3991.09090909091 3949 0.0711572888183566 2962 0.289721925391357 -0.277738482365156 -1 0.0797102609464238 3892 4392 2962 4578 3949 3416 4514 3727 4516 4422 3534 4378 M11745 GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. 11/25 Gene Ontology BP GO:0044818 0.988438980056112 0.996811942745553 4305 3961.36363636364 3950 0.333333333333333 2974 0.741816254250424 -0.443795337545927 -1 0.00121696567494968 4303 3919 2974 3950 4350 3598 3651 4503 4443 3649 4235 4379 M13063 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. 7/30 Gene Ontology BP GO:0002532 0.0170386710535209 0.0220732560551054 4575 3481.18181818182 3950 0.00171707408255769 1257 2.76531437931173 -3.39257602757827 -1 5.42522615679739 4575 3950 4003 2678 3382 4374 4339 3042 1257 2383 4310 4380 M16723 GO_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_TRANSPORT.html The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 35/102 Gene Ontology BP GO:0015833 0.0839184282471183 0.0949861682962873 4235 3723.18181818182 3952 0.00793650793650794 1673 1.58100148270457 1.86712311800227 1 1.91471964907106 4231 3427 1673 3886 3952 4217 4549 4624 3324 2499 4573 4381 M12624 GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE.html A cascade of processes induced by the detection of DNA damage within a cell. 60/128 Gene Ontology BP GO:0042770 0.0839184282471183 0.0949861682962873 4450 3840.63636363636 3953 0.00793650793650794 2464 2.17988471526654 -1.79228604992037 -1 2.64001593284588 4449 4612 2764 4537 4287 3243 3953 4257 2464 3860 3821 4382 M10437 GO_MULTI_ORGANISM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_TRANSPORT.html The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. 38/115 Gene Ontology BP GO:0044766 0.232850105696956 0.253922063757934 3955 3868.54545454545 3954 0.0238095238095238 2780 1.25271880242907 -1.17988851053557 -1 0.88341838458468 3954 4482 3088 4504 3968 4095 4590 2780 3810 3442 3841 4383 M14095 GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. 6/21 Gene Ontology BP GO:1900273 0.263126691755441 0.285443277995447 4455 3527.27272727273 3954 0.0300724784757114 1513 0.483897453578455 0.483897453578455 1 0.312112508040185 2745 4454 4184 3954 4387 2404 1513 3445 4529 4452 2733 4384 M13896 GO_MULTI_ORGANISM_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_LOCALIZATION.html A localization which involves another organism. 38/115 Gene Ontology BP GO:1902579 0.232850105696956 0.253922063757934 3955 3873.90909090909 3955 0.0238095238095238 2829 1.25271880242907 -1.17988851053557 -1 0.88341838458468 3955 4483 3089 4505 3969 4096 4591 2829 3811 3443 3842 4385 M13802 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. 55/128 Gene Ontology BP GO:2001251 0.980979042799408 0.991874062656283 2600 3818.90909090909 3959 0.302464076491744 2598 0.767439656863166 0.858965675569172 1 0.00321976272462998 2598 4551 3381 4338 4271 3513 3289 3565 4423 4120 3959 4386 M16204 GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. 34/68 Gene Ontology BP GO:0008156 0.0839184282471183 0.0949861682962873 3780 3802.18181818182 3960 0.00793650793650794 2459 1.55658116476362 -0.642499017069254 -1 1.88514465867535 3780 4554 2682 4470 4427 4315 3928 2459 2850 3960 4399 4387 M16460 GO_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERAD_PATHWAY.html Any process that modulates the frequency, rate or extent of ERAD pathway. 19/37 Gene Ontology BP GO:1904292 6.17927885915919e-06 1.66224749380511e-05 4355 3699.81818181818 3960 5.61754201396182e-07 1620 0.927897594661608 -0.753722486184525 -1 5.25342692778975 4354 3434 2918 4214 1620 4090 4270 4401 3813 3624 3960 4388 M11204 GO_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_PROLIFERATION.html The expansion of a B cell population by cell division. Follows B cell activation. 13/53 Gene Ontology BP GO:0042100 0.0839184282471183 0.0949861682962873 4450 3741.72727272727 3962 0.00793650793650794 2580 1.46021899994303 1.78463598370925 1 1.768442242844 4450 3807 2580 3141 3983 4068 4616 3962 2719 3743 4090 4389 M12129 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition. 11/30 Gene Ontology BP GO:1902751 0.574125372415626 0.602409967034068 4175 3867.81818181818 3962 0.0746663782329873 2845 1.06633161187223 -1.02225042359124 -1 0.278037447679394 4172 3667 2845 3939 3962 4563 4066 3638 4162 2928 4604 4390 M13588 GO_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that modulates the frequency, rate or extent of muscle hypertrophy. 23/55 Gene Ontology BP GO:0014743 0.752724079456358 0.778894116540199 3060 3662.18181818182 3964 0.119286382169658 2299 1.0217233657078 -1.4173544028524 -1 0.131347545398499 3060 4558 2928 4428 4138 2670 2299 4080 4298 3964 3861 4391 M15562 GO_PROTEIN_REFOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_REFOLDING.html The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. 17/28 Gene Ontology BP GO:0042026 0.999010488230118 0.99996766030127 3055 3982.09090909091 3964 0.46684136021087 3055 0.624865148305518 -0.432040579017068 -1 8.71487457165988e-06 3055 4343 3182 3916 4357 3800 3964 4113 4583 4562 3928 4392 M11783 GO_AEROBIC_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AEROBIC_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. 33/63 Gene Ontology BP GO:0009060 0.726439524070579 0.753038336740276 3515 3903 3967 0.111161143704677 3407 0.955151986845943 -0.955151986845943 -1 0.139378509809032 3512 3967 3407 3986 4019 3655 3727 4099 4475 4288 3798 4393 M13491 GO_REGULATION_OF_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_CYCLE.html Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. 27/54 Gene Ontology BP GO:0046605 0.768714199158014 0.794554769966754 2980 3643.45454545455 3969 0.124622537570584 2592 0.595637374297408 -0.561131961762008 -1 0.0704711758619707 2978 3969 3079 4317 4106 2592 2613 4232 4512 4416 3264 4394 M12532 GO_SECRETORY_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. 18/40 Gene Ontology BP GO:0033363 0.000117580600505094 0.000210133459640167 3830 3716.09090909091 3972 1.06897168323706e-05 2469 1.11318726882234 -0.78624837181116 -1 4.84952752709585 3830 3972 2598 4209 2469 4578 4085 4181 3891 3019 4045 4395 M14187 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE.html The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. 7/15 Gene Ontology BP GO:1990126 0.638207377824571 0.666635962933517 2610 3719.36363636364 3972 0.0966709629514284 2391 0.194660999212581 0.214839560656034 1 0.0406093644231098 2607 4506 4200 3972 4484 3615 2391 3139 4616 4457 2926 4396 M14124 GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. 18/30 Gene Ontology BP GO:0032469 0.280841862541149 0.303809125763875 3530 3885.54545454545 3973 0.0295257059554493 3000 0.954257834343632 -0.811385032410593 -1 0.584882096155035 3526 3973 3000 4032 3808 3815 4203 4212 4191 3892 4089 4397 M10472 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. 9/16 Gene Ontology BP GO:0032211 0.769059048456691 0.794734289335503 3200 3779 3977 0.136325504270085 2402 0.754639173726346 0.754639173726346 1 0.0891957713471003 3198 4312 3591 3977 4540 3393 2402 3326 4615 4204 4011 4398 M15074 GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 24/87 Gene Ontology BP GO:0002275 0.985023615986936 0.994467127727277 4410 4009.54545454545 3977 0.317460317460317 3011 0.783863009259336 -0.783863009259336 -1 0.00223578947078594 4407 4337 3011 4321 4640 3860 3752 3634 4427 3977 3739 4399 M13382 GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. 8/19 Gene Ontology BP GO:0007095 0.879243859351689 0.898993446150604 4045 3707.45454545455 3978 0.190548331767642 2656 0.741816254250424 -0.443795337545927 -1 0.0406356236567116 4042 3353 4064 3312 4217 2922 2656 4500 4347 3391 3978 4400 M11429 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION.html Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. 12/23 Gene Ontology BP GO:0010569 0.890389589298165 0.910189093595637 3905 3907.36363636364 3979 0.182074401498386 2929 0.569236511420671 0.569236511420671 1 0.0275569845609935 3901 4167 2929 4250 4115 3493 3647 3907 4326 4267 3979 4401 M12907 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. 8/16 Gene Ontology BP GO:0070198 0.0275900535064441 0.0350288811677386 1960 2976.09090909091 3979 0.00279387063716148 1006 0.517174830436356 -0.517174830436356 -1 0.891761817902073 1960 3986 3979 4034 4321 1240 1006 1736 4571 4367 1537 4402 M12575 GO_REGULATION_OF_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_SILENCING.html Any process that affects the rate, extent or location of chromatin silencing. 12/33 Gene Ontology BP GO:0031935 0.466738071388703 0.4949590645891 3620 3988.90909090909 3986 0.0555555555555556 3051 1.56416128821162 1.56416128821162 1 0.565940868710135 3619 3914 3051 3781 4521 4339 4377 4511 3986 3696 4083 4403 M12983 GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. 6/20 Gene Ontology BP GO:0014821 4.39455021696268e-05 8.74952686850674e-05 4425 3363 3989 4.39463712370373e-06 1335 1.62249948602713 -0.751976009954791 -1 7.79967074975871 4421 1951 3989 1335 2234 4198 4355 4275 2707 3131 4397 4404 M13855 GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION.html The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. 19/34 Gene Ontology BP GO:0043687 0.0839184282471183 0.0949861682962873 3050 3635.45454545455 3989 0.00793650793650794 2486 1.48263387393573 1.91386691470621 1 1.795588477576 3048 4244 2869 4205 4170 4282 4031 3989 2762 3904 2486 4405 M13021 GO_LYSOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_LOCALIZATION.html Any process in which a lysosome is transported to, and/or maintained in, a specific location. 15/47 Gene Ontology BP GO:0032418 0.664938308055248 0.69271520229793 3980 3905.18181818182 3990 0.0946228590258847 2194 0.807442035318573 -0.636933935209298 -1 0.152509303811078 3977 3975 2576 3911 3990 4422 2194 4484 4463 4371 4594 4406 M15466 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. 104/264 Gene Ontology BP GO:0031110 0.0839184282471183 0.0949861682962873 3755 3879.90909090909 3990 0.00793650793650794 2804 1.45890057785717 -0.795872844598027 -1 1.76684552651045 3751 4326 3014 3990 4573 4608 3746 2804 3358 4074 4435 4407 M11928 GO_HISTONE_H3_K9_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K9_MODIFICATION.html The modification of histone H3 at a lysine in position 9 of the histone. 12/20 Gene Ontology BP GO:0061647 0.664964819436113 0.69271520229793 3985 3939.18181818182 3991 0.0946293717102653 3165 0.269570081859392 -0.220646817636822 -1 0.0509151606637738 3981 4038 3165 4247 3991 3233 3733 4573 4488 4299 3583 4408 M14518 GO_DNA_METHYLATION_OR_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_OR_DEMETHYLATION.html The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. 26/65 Gene Ontology BP GO:0044728 0.0839184282471183 0.0949861682962873 4110 3895.54545454545 3991 0.00793650793650794 3147 1.46955025147849 -0.643603609497213 -1 1.77974314708318 4106 3970 3147 4014 4044 4302 3885 3853 3377 3991 4162 4409 M12040 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. 88/246 Gene Ontology BP GO:0070972 0.164388308429132 0.182161077812998 3155 3517.63636363636 3992 0.0161939233831671 1577 0.636917796989731 -0.567037763385142 -1 0.557987458006829 3153 4415 3505 3992 4548 1577 1958 4289 4448 4308 2501 4410 M16081 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. 26/60 Gene Ontology BP GO:1904356 0.33868500354299 0.364345336295204 3365 3564.72727272727 3992 0.0368953309457993 1942 0.864807017613871 -0.901529632243046 -1 0.449212869955523 3363 4292 3115 4263 4558 1942 2070 4424 4435 3992 2758 4411 M13681 GO_ACROSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_ASSEMBLY.html The formation of the acrosome from the spermatid Golgi. 8/18 Gene Ontology BP GO:0001675 0.147859119791321 0.16482830568814 4165 3849.81818181818 3993 0.0158730158730159 3148 0.810963292445038 -0.86608371274194 -1 0.752181164765066 4161 3779 4115 4204 4299 3993 4005 3148 3752 3396 3496 4412 M11114 GO_MITOCHONDRIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSPORT.html Transport of substances into, out of or within a mitochondrion. 120/271 Gene Ontology BP GO:0006839 0.0839184282471183 0.0949861682962873 3995 3818.36363636364 3995 0.00793650793650794 2802 1.28917286548551 -0.864297580820169 -1 1.56129146798364 3995 4597 3355 4572 4279 2802 3386 4130 3086 4041 3759 4413 M13028 GO_REGULATION_OF_HEXOKINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEXOKINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hexokinase activity. 5/14 Gene Ontology BP GO:1903299 0.971737472846499 0.984643148327764 4005 3985.81818181818 3996 0.299962831899402 3376 0.72888579324872 -0.72888579324872 -1 0.00580168909442652 4003 4142 3996 3776 4544 3801 3376 3663 4574 4372 3597 4414 M11281 GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. 27/77 Gene Ontology BP GO:1903313 0.690133268184572 0.71748516887169 3425 3773.63636363636 4000 0.101034184371746 2529 1.082377024765 -1.082377024765 -1 0.184875362375477 3425 4625 3315 4332 4613 2529 2563 4604 4557 4000 2947 4415 M13064 GO_PREPULSE_INHIBITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREPULSE_INHIBITION.html The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. 4/22 Gene Ontology BP GO:0060134 0.442171776119565 0.470333002639894 4425 3705 4004 0.056699535258515 2454 0.701184282158677 -0.701184282158677 -1 0.272109843826898 4424 2454 4004 2519 3911 3538 2560 4490 4403 4378 4074 4416 M16726 GO_PHAGOCYTOSIS_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_RECOGNITION.html The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. 6/130 Gene Ontology BP GO:0006910 0.481063017846562 0.509019050105193 4370 3908.36363636364 4004 0.0634920634920635 2871 2.53525564949683 -2.53525564949683 -1 0.880766308994266 4367 3165 4611 3799 4250 4358 4625 2871 4004 3160 3782 4417 M16007 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. 10/23 Gene Ontology BP GO:1903427 0.698152987361708 0.725011031160906 4545 3730.90909090909 4007 0.103174603174603 2325 1.06666718403395 -0.871287411091255 -1 0.17646581452964 4545 3474 2325 3496 4007 4604 3171 4377 4163 2841 4037 4418 M13895 GO_SPERMATID_NUCLEUS_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_NUCLEUS_DIFFERENTIATION.html The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. 11/134 Gene Ontology BP GO:0007289 0.775485941583084 0.800484932585651 3875 3974.36363636364 4009 0.126984126984127 2907 0.850051621763471 -1.13086673210627 -1 0.0973203245234957 3873 4009 2907 3896 4464 4447 4034 3705 4217 3657 4509 4419 M16545 GO_RESPONSE_TO_HISTAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HISTAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. 4/19 Gene Ontology BP GO:0034776 0.455340346747895 0.483811265235424 4010 3822.45454545455 4009 0.0589503868075771 2592 0.582575145397234 -0.73327274020202 -1 0.217612459380743 4009 4263 4577 3833 4249 3489 2592 2656 4251 4618 3510 4420 M15485 GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. 76/170 Gene Ontology BP GO:0051053 0.0839184282471183 0.0949861682962873 4015 3866.09090909091 4011 0.00793650793650794 2478 1.46274720144627 -0.787103786418802 -1 1.77150410040693 4011 4540 3100 4057 3930 4488 4471 2478 2927 4003 4522 4421 M11965 GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. 11/22 Gene Ontology BP GO:1903894 0.413690744459073 0.442165314577227 3610 3834.18181818182 4012 0.047377985333753 2568 0.868381686716138 0.868381686716138 1 0.364585381621921 3607 4012 2950 3334 4139 4445 4328 2568 4535 4304 3954 4422 M13259 GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. 78/178 Gene Ontology BP GO:0032845 0.0839184282471183 0.0949861682962873 4025 3698.45454545455 4012 0.00793650793650794 1845 1.29123543735819 -1.08584610049236 -1 1.56378941020833 4023 4082 1845 4012 4097 3516 4050 3901 3506 3226 4425 4423 M13105 GO_MATURATION_OF_LSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_LSU_RRNA.html Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. 7/17 Gene Ontology BP GO:0000470 0.987296183872049 0.99630866805432 3575 4093.27272727273 4014 0.353760618869324 3574 0.564703027248038 -0.564703027248038 -1 0.00107272427359882 3574 4505 4014 4359 4605 3644 3848 3674 4563 4381 3859 4424 M12559 GO_ATRIAL_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_MORPHOGENESIS.html The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. 8/20 Gene Ontology BP GO:0060413 0.059657548713317 0.0729112920968494 4120 3913.54545454545 4016 0.00613223663379711 2525 1.47578857662426 -1.29214926568553 -1 1.98811140905751 4117 4016 3930 4289 3564 4227 3742 4036 4006 2525 4597 4425 M12744 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION.html Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. 82/173 Gene Ontology BP GO:0071166 0.796944161638877 0.820628020068597 3345 3907.09090909091 4016 0.134920634920635 3343 1.31354082340957 -1.31354082340957 -1 0.133590327534086 3343 4607 3471 4197 4423 3390 4016 3678 4235 4140 3478 4426 M16594 GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process that decreases the concentration of calcium ions in the cytosol. 8/20 Gene Ontology BP GO:0051481 0.327237671322626 0.352357260656529 4020 3657.63636363636 4016 0.0388610739140834 2048 1.43098949711719 -1.72821084271754 -1 0.767941045782563 4016 2734 4589 2867 3859 4047 2048 4639 4244 2548 4643 4427 M12282 GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 106/233 Gene Ontology BP GO:0010822 0.00147185500718267 0.00215782216556651 4550 3760.36363636364 4017 0.000133894603480352 2505 1.35930032633786 -0.814450333261386 -1 4.2929017431582 4547 4271 3299 4378 2988 2505 3855 4568 2879 4057 4017 4428 M16704 GO_METAPHASE_PLATE_CONGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAPHASE_PLATE_CONGRESSION.html The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. 29/51 Gene Ontology BP GO:0051310 0.809937282778105 0.832714527001493 2990 3663 4018 0.140105490790265 2557 0.730360943096072 -0.550142678930595 -1 0.0687849194086094 2986 4490 2867 4431 4101 2678 2557 4256 4569 4018 3340 4429 M14208 GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 9/24 Gene Ontology BP GO:0002381 0.481063017846562 0.509019050105193 4270 3928.09090909091 4019 0.0634920634920635 2241 0.569944343140344 -0.623400820683481 -1 0.198001519258214 4267 2241 4203 3694 3954 3828 4381 4233 4019 4458 3931 4430 M10426 GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 41/93 Gene Ontology BP GO:0036498 0.63389956273523 0.662434316853403 3925 4004.81818181818 4021 0.0873015873015873 3406 0.802850120352287 -0.659013612737573 -1 0.170104051446576 3921 3960 3406 4122 4021 4503 3800 3548 4127 4079 4566 4431 M10037 GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that activates or increases the frequency, rate or extent of viral transcription. 22/51 Gene Ontology BP GO:0050434 0.232850105696956 0.253922063757934 4185 3983.72727272727 4025 0.0238095238095238 3254 0.887392631220279 0.699872747577889 1 0.625789561762232 4184 3767 3254 4025 4095 4417 4424 3556 3814 3731 4554 4432 M15732 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY.html Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. 4/17 Gene Ontology BP GO:0010715 0.275742742869669 0.298571258195865 4365 3781.90909090909 4026 0.0317460317460317 2215 1.2747791581514 1.2747791581514 1 0.792741749635486 4361 2969 4449 2215 4632 4477 4026 3310 3848 2797 4517 4433 M13754 GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION.html The directed movement of the nucleus to a specific location within a cell. 8/29 Gene Ontology BP GO:0040023 6.37382775626546e-05 0.000121285583083363 4100 3335.09090909091 4027 6.37401057920683e-06 115 6.00900434550934 6.00900434550934 1 27.8768975196623 4097 4503 4129 3492 3877 4059 4576 414 115 3397 4027 4434 M13250 GO_POST_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_MORPHOGENESIS.html The process, occurring after embryonic development, by which anatomical structures are generated and organized. 6/17 Gene Ontology BP GO:0009886 0.352862545366102 0.379157787117522 4400 3913.90909090909 4028 0.0425862648118528 2539 0.347190374030935 -0.134154792728558 -1 0.173224502230561 3480 4397 4038 4028 4327 3983 3587 2539 4348 4396 3930 4435 M14587 GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 8/26 Gene Ontology BP GO:0032924 0.102753981511203 0.115741566267956 4060 3994.27272727273 4028 0.0107839504040536 3400 0.966594988490266 0.976205625502617 1 1.07234536220658 4060 3812 4254 3483 3645 3994 4608 4282 4028 3400 4371 4436 M10626 GO_RESPONSE_TO_IMMOBILIZATION_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IMMOBILIZATION_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. 7/28 Gene Ontology BP GO:0035902 0.148308811459568 0.165250254765245 4030 3972.45454545455 4029 0.0159249625458783 3459 0.546979962379884 -0.412898196259476 -1 0.506612480803727 4029 3587 3612 4084 3706 4613 3459 3714 4247 4210 4436 4437 M10182 GO_CYTOKINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 6/19 Gene Ontology BP GO:0042107 0.652261937299541 0.680551050535229 3655 3979.09090909091 4031 0.10024302293203 3253 0.355970801978855 -0.145581921329523 -1 0.0704791523518022 3651 4313 3551 4404 4000 4031 3877 3253 4234 4188 4268 4438 M15787 GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. 32/77 Gene Ontology BP GO:0000245 0.848987846459178 0.869781679415262 3465 3883.27272727273 4031 0.157897962266555 3071 0.925107601193309 -0.925107601193309 -1 0.0663985309999901 3464 4555 3412 4508 4401 3071 3628 4108 4356 4031 3182 4439 M16147 GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS.html The process in which the structure of the atrioventricular valve is generated and organized. 9/26 Gene Ontology BP GO:0003181 0.481063017846562 0.509019050105193 4040 3940.18181818182 4031 0.0634920634920635 2703 1.17324080309542 -1.29214926568553 -1 0.407591511081635 4038 3841 4518 3884 4333 4606 3998 3079 4031 2703 4311 4440 M13816 GO_NEGATIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BEHAVIOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 5/21 Gene Ontology BP GO:0048521 0.0765897756730953 0.0916038970762961 4140 3571.81818181818 4035 0.00793650793650794 1840 1.57937424341912 -0.82915100755709 -1 1.94220975786982 4138 3540 4136 2953 4035 4441 1840 4365 2648 2989 4205 4441 M15325 GO_COENZYME_A_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 6/11 Gene Ontology BP GO:0015937 0.747921687962607 0.77454339971379 3855 3892.45454545455 4037 0.12872841962126 2611 0.116275006094539 -0.128849364179936 -1 0.0152813102596261 3855 4111 4387 4037 4218 2611 2778 3941 4627 4543 3709 4442 M12690 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. 31/84 Gene Ontology BP GO:0032873 7.15765652702281e-05 0.000134404063499791 4115 3500.09090909091 4038 6.50717219142832e-06 1682 1.6878037342693 -0.993289430101862 -1 7.74085693625379 4111 4088 2613 4038 2346 4590 4099 2394 1682 3929 4611 4443 M14839 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 31/84 Gene Ontology BP GO:0070303 7.15765652702281e-05 0.000134404063499791 4115 3490.63636363636 4039 6.50717219142832e-06 1683 1.6878037342693 -0.993289430101862 -1 7.74085693625379 4112 4089 2614 4039 2347 4591 4100 2280 1683 3930 4612 4444 M15445 GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. 5/20 Gene Ontology BP GO:0036148 0.480480431450551 0.508866478837799 3890 3809.63636363636 4039 0.0633869791820437 2654 0.379564732733847 -0.429571994204875 -1 0.131920667285975 3886 4048 4406 4159 4039 3535 2654 2685 4498 4551 3445 4445 M15796 GO_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. 8/31 Gene Ontology BP GO:0032528 0.503982019400088 0.532541765151254 2240 3597.09090909091 4039 0.0677127560990801 2237 0.38315401351725 0.399037604566718 1 0.124203897156048 2414 4039 4458 4400 4566 2237 2240 3341 4444 4578 2851 4446 M15868 GO_DNA_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. 13/17 Gene Ontology BP GO:0006266 0.416243375224207 0.444382154786386 4045 4037.09090909091 4041 0.0477557750803759 3043 0.654162550255648 -0.654162550255648 -1 0.272963108549036 4041 3977 3043 4092 3884 3638 4311 4582 4586 4580 3674 4447 M10053 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. 11/25 Gene Ontology BP GO:1900225 0.0101128054316798 0.013388581585198 4620 3850 4042 0.00092359933080741 2738 0.554170537432062 -0.554170537432062 -1 1.22975970660122 4617 3586 2999 2738 3304 4042 4561 3780 4396 4182 4145 4448 M13377 GO_GRANULOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_ACTIVATION.html The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 11/32 Gene Ontology BP GO:0036230 0.237727153187769 0.258857216756757 3985 3949.27272727273 4042 0.0243753419890089 3010 0.574762572684831 -0.574762572684831 -1 0.399630159758751 3985 3349 3010 3427 3769 4444 4057 4042 4418 4403 4538 4449 M16419 GO_RRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. 9/20 Gene Ontology BP GO:0031167 0.701298544736183 0.727789258652234 4045 4087.18181818182 4043 0.113816348432516 2682 0.277521287266047 -0.210782574283079 -1 0.0453648662693448 4043 4018 4562 4170 4024 3918 2682 3905 4502 4610 4525 4450 M16547 GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION.html Any process that modulates the frequency, rate or extent of sister chromatid segregation. 40/81 Gene Ontology BP GO:0033045 0.298735036746822 0.322639398840543 3870 4032.09090909091 4043 0.0317460317460317 3193 1.08589174970021 -1.10790040817893 -1 0.631967671545415 4433 4122 3193 4043 4053 4426 4419 3868 3867 3926 4003 4451 M10265 GO_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXPORT_FROM_NUCLEUS.html The directed movement of a protein from the nucleus into the cytoplasm. 23/55 Gene Ontology BP GO:0006611 0.698152987361708 0.725011031160906 3615 4060.63636363636 4045 0.103174603174603 3213 1.03409616961162 -1.29326977463156 -1 0.171077324612711 3614 4624 3213 4045 4447 4194 3872 3944 4166 3962 4586 4452 M15072 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. 10/39 Gene Ontology BP GO:0046636 0.136610899725664 0.152802796296376 4285 3849.18181818182 4050 0.0132648559745091 2631 1.46807889378281 -1.671870531444 -1 1.41888518138362 4281 3947 2631 4220 3684 4377 4295 3647 4050 2834 4375 4453 M16503 GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. 96/203 Gene Ontology BP GO:2001020 0.0348306366038952 0.0437195581919128 4155 3858.27272727273 4051 0.00321769272528672 3013 1.21410295640891 -1.03658136002683 -1 1.95504295889485 4152 4411 3207 4328 3460 3013 4206 4460 3522 4051 3631 4454 M16070 GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS.html The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. 25/57 Gene Ontology BP GO:0006921 0.976749981380386 0.988890135967975 4055 3945.63636363636 4052 0.289616234763908 3054 0.814634757778872 -0.837554011484312 -1 0.00468060291171293 4052 4557 3054 4535 4241 3338 3072 4235 4519 3983 3816 4455 M16267 GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 130/307 Gene Ontology BP GO:0040029 0.0839184282471183 0.0949861682962873 4380 3847.45454545455 4052 0.00793650793650794 2887 1.60880817087835 -1.11407406257457 -1 1.94839580913026 4378 4222 2922 3985 3638 3440 4536 4120 2887 4052 4142 4456 M12156 GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. 4/13 Gene Ontology BP GO:2000105 0.798307050343508 0.821428743014025 4315 3819.27272727273 4053 0.147942170046199 2718 0.211288961701485 -0.246302943141539 -1 0.0213811810347553 3389 4315 3858 4166 4543 2718 2863 4053 4631 4315 3161 4457 M12274 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that stops, prevents or reduces the rate of gene expression. 63/125 Gene Ontology BP GO:0045814 0.0839184282471183 0.0949861682962873 4640 4055.27272727273 4055 0.00793650793650794 2707 1.39237555535003 -0.917209431428355 -1 1.68627831577714 4640 4055 2707 3973 3892 4215 4573 4638 3465 3902 4548 4458 M13342 GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. 8/24 Gene Ontology BP GO:0031272 0.529317814249989 0.558170023066704 3650 3827.18181818182 4055 0.0725878609349132 2743 1.04974313065353 -1.04974313065353 -1 0.314905297303926 3648 4568 4055 4577 4430 2743 4191 2764 4478 3390 3255 4459 M15111 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. 5/14 Gene Ontology BP GO:0033033 0.0765897756730953 0.0916038970762961 4435 3944.72727272727 4055 0.00793650793650794 3004 1.18327848993981 -0.811385032410593 -1 1.45511703314568 4432 3617 4356 3645 4055 4246 3710 4425 3284 3004 4618 4460 M15661 GO_MATURATION_OF_5_8S_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA.html Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. 15/29 Gene Ontology BP GO:0000460 0.798368698533945 0.821428743014025 3680 4020.81818181818 4056 0.135474125692242 3242 0.635934458241998 -0.564703027248038 -1 0.0643561490828934 3680 4561 3274 4604 4056 3242 3565 4241 4530 4571 3905 4461 M14028 GO_NEURON_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_CELL_CELL_ADHESION.html The attachment of a neuron to another cell via adhesion molecules. 4/22 Gene Ontology BP GO:0007158 0.000159610741455087 0.000276210463129322 4200 2839.72727272727 4058 1.59622206629036e-05 514 1.82662959086752 -2.14665504610597 -1 7.70064638118338 4198 949 4174 1388 2566 4065 4058 4196 514 898 4231 4462 M14250 GO_DNA_REPLICATION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_CHECKPOINT.html A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. 8/15 Gene Ontology BP GO:0000076 0.99712476107312 0.99996766030127 3635 4119.36363636364 4059 0.442984354354061 3633 0.208281591226215 -0.307563682118693 -1 1.78368895645959e-06 3633 4351 4214 3975 4342 3808 3954 3930 4587 4460 4059 4463 M13502 GO_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SUMOYLATION.html The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. 71/158 Gene Ontology BP GO:0016925 0.0839184282471183 0.0949861682962873 3885 3992.27272727273 4062 0.00793650793650794 2831 1.34116732988753 -1.01042704021624 -1 1.62426099151884 3884 4544 3121 4513 4604 4479 2831 3886 3436 4062 4555 4464 M11077 GO_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 93/281 Gene Ontology BP GO:0006413 0.158921157007611 0.176777894582257 2590 3383.90909090909 4064 0.0156104980497761 1356 0.597093069265271 -0.56117589198106 -1 0.532312715624768 2590 4537 3498 4064 4297 1557 1356 4370 4293 4243 2418 4465 M11488 GO_MICROTUBULE_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_NUCLEATION.html The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). 6/24 Gene Ontology BP GO:0007020 0.579803850790179 0.608230745417714 3795 3823.45454545455 4067 0.0830509459622179 2059 0.229616693336475 -0.242795034451761 -1 0.0587334333833281 3795 4259 3757 4226 4067 3083 2059 4411 4401 4272 3728 4466 M10919 GO_CHROMOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION.html Any process in which a chromosome is transported to, or maintained in, a specific location. 40/72 Gene Ontology BP GO:0050000 0.90826130895632 0.926011694660561 3920 3942.90909090909 4072 0.195202544775085 3141 0.730360943096072 -0.550142678930595 -1 0.0288816894161568 3920 4484 3141 4510 4123 3206 3212 4364 4568 4072 3772 4467 M16040 GO_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_PHOSPHORYLATION.html The modification of histones by addition of phosphate groups. 18/59 Gene Ontology BP GO:0016572 0.557443745451391 0.58636413913249 4060 3997.45454545455 4072 0.0714285714285714 2245 1.01652279101968 0.86134871363097 1 0.279168946733873 4056 4341 2245 3901 4050 4379 4305 4476 4072 3554 4593 4468 M16908 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 3/32 Gene Ontology BP GO:0032225 0.568414261364439 0.596957117284571 3755 4077.45454545455 4074 0.0805953232813717 2827 0.196191852784077 -0.229046598684678 -1 0.0520718851125943 3752 4074 4635 3831 4328 4069 4169 2827 4592 4639 3936 4469 M10789 GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 7/25 Gene Ontology BP GO:0002281 0.275742742869669 0.298571258195865 4560 4019.45454545455 4075 0.0317460317460317 3271 1.13989251988388 -1.13989251988388 -1 0.708860164513556 4560 4452 3635 3667 4498 4292 4556 3343 3865 3271 4075 4470 M12155 GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. 271/568 Gene Ontology BP GO:0010608 0.0839184282471183 0.0949861682962873 4560 3990.54545454545 4075 0.00793650793650794 3110 1.42935982445825 -1.11835017116991 -1 1.7310692724843 4558 4585 3476 4386 3835 3298 4241 4265 3110 4075 4067 4471 M12839 GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. 12/25 Gene Ontology BP GO:0060716 0.00808556215614947 0.0108500766158965 4360 3876.81818181818 4079 0.0007377665881862 2762 0.76938764743412 0.801069135706586 1 1.79056376246475 3767 3499 2762 3279 3275 4421 4550 4294 4079 4359 4360 4472 M15571 GO_RESPONSE_TO_SALT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. 7/19 Gene Ontology BP GO:1902074 0.187460243332518 0.206838856889943 4085 3803.90909090909 4082 0.0205450577969379 2245 0.881719376632644 -1.082377024765 -1 0.714820629176978 3809 3385 4425 4082 4433 4082 4343 2245 4134 3298 3607 4473 M15760 GO_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 360/808 Gene Ontology BP GO:0010564 0.0839184282471183 0.0949861682962873 4420 3908.36363636364 4082 0.00793650793650794 2887 1.32851869286192 -1.24326020622337 -1 1.608942463748 4420 4516 3367 4387 4165 2887 4079 4100 3294 4082 3695 4474 M13221 GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. 21/44 Gene Ontology BP GO:0070911 0.301838183829538 0.325915043609429 4085 3916.72727272727 4083 0.0321363258077432 2884 0.49519691791412 -0.511279682844146 -1 0.285620464490383 4083 4243 3391 4322 3822 2884 4394 3626 4429 4390 3500 4475 M16319 GO_KINETOCHORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 5/12 Gene Ontology BP GO:0051383 0.665779021111741 0.693407805074432 2965 3858.63636363636 4085 0.103803237519903 2964 0.307329785900469 -0.417221503123173 -1 0.0578892677690322 3189 4456 4549 4085 4509 2965 3003 2964 4528 4606 3591 4476 M11010 GO_NEGATIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RNA_SPLICING.html Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. 18/50 Gene Ontology BP GO:0033119 0.965648440220458 0.979145164434066 4510 3943.18181818182 4087 0.263955242487838 3184 0.758479313772085 0.758479313772085 1 0.00822228498719048 4510 4193 3297 3286 4520 3184 3676 4087 4469 4239 3914 4477 M12137 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 15/30 Gene Ontology BP GO:0051985 0.968328558691422 0.981434075093707 2855 3921 4087 0.269370715531774 2852 0.463783137878565 -0.407978698483221 -1 0.00446985739625727 2852 4346 3049 3914 4199 3706 4354 3735 4577 4312 4087 4478 M12271 GO_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOSIS_I.html The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. 44/204 Gene Ontology BP GO:0007127 0.939337251318938 0.956225138757691 2475 3900.27272727273 4087 0.22490211265181 2474 0.817406431507993 0.888727210494804 1 0.0188221879191957 2474 4481 3084 4538 4152 3614 3456 4556 4474 4087 3987 4479 M10604 GO_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION.html The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. 272/718 Gene Ontology BP GO:0051301 0.0839184282471183 0.0949861682962873 3270 3948.72727272727 4089 0.00793650793650794 3102 1.3349972271012 -0.996651569623022 -1 1.61678849541591 3267 4518 3102 4473 3886 4639 4253 3573 3345 4089 4291 4480 M16020 GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. 6/28 Gene Ontology BP GO:0036151 0.0429164403672825 0.0532926003277059 3285 3464.90909090909 4089 0.00437685126557723 1718 0.305021743709197 -0.300271454862101 -1 0.460096933143035 3281 4214 4495 4089 4413 2541 1823 1718 4308 4585 2647 4481 M13932 GO_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. 207/504 Gene Ontology BP GO:0051052 0.0839184282471183 0.0949861682962873 4090 3822.54545454545 4090 0.00793650793650794 2653 1.27888973145793 -0.997610491369711 -1 1.54883775665855 4090 4360 3251 4196 4240 2653 3427 4640 3528 4114 3549 4482 M14673 GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 37/68 Gene Ontology BP GO:1901028 0.0839184282471183 0.0949861682962873 4095 3899.27272727273 4091 0.00793650793650794 2485 1.53626694449246 -0.750699581482554 -1 1.86054248638306 4091 4284 2936 3790 4526 4169 4401 3585 2485 3987 4638 4483 M14635 GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. 14/38 Gene Ontology BP GO:0002367 0.17486127529805 0.19348925195635 4405 3885.36363636364 4094 0.0173212998701058 2865 1.33580728127461 -0.751976009954791 -1 1.1288071689783 4403 4195 2865 3050 3715 4134 4094 4502 3838 3783 4160 4484 M16532 GO_CELLULAR_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_DEFENSE_RESPONSE.html A defense response that is mediated by cells. 29/121 Gene Ontology BP GO:0006968 0.0839184282471183 0.0949861682962873 4215 3852.54545454545 4094 0.00793650793650794 2424 1.62329952268951 1.62024603886264 1 1.96594601431891 4214 3709 2424 4219 4110 3357 4528 4574 3438 3711 4094 4485 M11741 GO_HISTONE_H2A_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_MONOUBIQUITINATION.html The modification of histone H2A by addition of a single ubiquitin group. 13/15 Gene Ontology BP GO:0035518 0.268934823351737 0.291471611769868 4640 4051.81818181818 4097 0.0280758521434745 3192 0.673348897277562 -0.353288843975212 -1 0.42706889689333 4636 3718 3192 3962 3796 3742 4097 4311 4508 4285 4323 4486 M12317 GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. 67/140 Gene Ontology BP GO:0007006 0.0839184282471183 0.0949861682962873 4110 3962.18181818182 4107 0.00793650793650794 2941 1.34301592141339 -0.759489296964522 -1 1.62649978614695 4107 4372 3232 4430 4308 3743 4458 3520 2941 3943 4530 4487 M15564 GO_RRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. 8/20 Gene Ontology BP GO:0016075 0.211324913575616 0.231848197951698 3370 3953.63636363636 4107 0.0234605056915251 3254 0.689550038146136 -0.689550038146136 -1 0.518533536399001 3366 4107 4424 4356 3760 3254 4138 3514 4471 4564 3536 4488 M13655 GO_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_SALVAGE.html Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. 8/17 Gene Ontology BP GO:0043174 1.25526287425461e-05 3.00267157401554e-05 4470 3632.63636363636 4111 1.25526996489296e-06 1512 0.825230291015657 -0.793694991344058 -1 4.42110592943779 4470 1512 4111 3056 1857 4181 4557 4590 4138 3395 4092 4489 M11463 GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL.html The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. 983/2289 Gene Ontology BP GO:0051649 0.00023162514498305 0.000391067472056837 4575 3700 4112 2.31649291118769e-05 2130 1.37189582307421 -1.15238942197066 -1 5.5381742267316 4396 4574 3750 4575 2645 2130 4215 4497 2845 4112 2961 4490 M12629 GO_TELOMERE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_LOCALIZATION.html Any process in which a telomere is transported to, and/or maintained in, a specific location. 5/12 Gene Ontology BP GO:0034397 0.992641917491019 0.999408332941965 3175 4014.09090909091 4112 0.388105618667595 3171 0.223091556967275 0.225831704334868 1 6.62466754502679e-05 3171 4112 3941 4487 4504 3517 3364 4345 4556 4348 3810 4491 M11449 GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 4/12 Gene Ontology BP GO:0046349 0.97191892069484 0.984643148327764 3570 4051 4113 0.300413565489763 3566 0.219486773492679 -0.197288940403926 -1 0.00174586657896106 4244 4113 3747 3829 4221 3566 3570 4516 4607 4268 3880 4492 M13676 GO_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the cell cycle. 560/1342 Gene Ontology BP GO:0051726 9.43753469135678e-07 4.2305182501105e-06 3865 3824.72727272727 4113 9.43753869937691e-08 960 1.30528669258783 1.39891621174514 1 8.30901951331683 3864 4511 4113 4438 960 3307 4560 4629 3248 4086 4356 4493 M14534 GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. 43/110 Gene Ontology BP GO:0031023 0.466738071388703 0.4949590645891 4515 4073.81818181818 4115 0.0555555555555556 3156 0.91922878636239 0.962228901076551 1 0.332592333803984 4514 4156 3156 3974 4510 3775 4115 4524 3989 3846 4253 4494 M15516 GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION.html Any process that modulates the frequency, rate or extent of interferon-gamma secretion. 6/15 Gene Ontology BP GO:1902713 0.836298274365542 0.857159577898281 4580 3949.36363636364 4120 0.16554038001183 2200 1.17333214044331 -1.082377024765 -1 0.0930392095951765 4580 4140 4416 3948 4098 4166 3643 3742 4390 2200 4120 4495 M13717 GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 9/34 Gene Ontology BP GO:0002323 0.0216027897784863 0.0276618182409023 4525 3583.45454545455 4121 0.00218157150445602 1529 1.14758623089073 -0.60963084848563 -1 2.11818450249078 4522 2410 4121 2510 4400 4288 4435 1529 3096 3497 4610 4496 M13578 GO_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_GENOME_REPLICATION.html Any process involved directly in viral genome replication, including viral nucleotide metabolism. 15/31 Gene Ontology BP GO:0019079 0.570407781045801 0.598915270781469 4340 3991.63636363636 4122 0.0739349555228069 2779 0.651472299306776 -0.651472299306776 -1 0.171815559526096 4338 3801 3162 3949 4591 4122 4558 2779 4361 4423 3824 4497 M15413 GO_NUCLEAR_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXPORT.html The directed movement of substances out of the nucleus. 106/222 Gene Ontology BP GO:0051168 0.63389956273523 0.662434316853403 4095 4119.09090909091 4124 0.0873015873015873 3475 1.29773936583217 -1.30774909518728 -1 0.274959859288732 4092 4602 3475 4142 4580 3830 4503 3958 4124 4137 3867 4498 M14069 GO_CELLULAR_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 3/13 Gene Ontology BP GO:0071294 0.798429445880313 0.821428743014025 3660 3927.45454545455 4127 0.147993890527969 2983 0.156558424153099 -0.156558424153099 -1 0.0158423418817186 3659 4316 4179 3661 4582 2983 3507 4127 4595 4451 3142 4499 M16451 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 14/48 Gene Ontology BP GO:0032786 0.252180904343365 0.274017303736542 4190 4041.36363636364 4128 0.0260717592192293 3205 0.852049796352599 0.852049796352599 1 0.567478792700275 4186 4345 3205 4459 3779 3479 3711 4128 4545 4613 4005 4500 M12250 GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 140/301 Gene Ontology BP GO:0010821 0.000183534837815396 0.000315261654449458 4170 3810 4131 1.66863773622037e-05 2569 1.24908966773951 -0.806514305631889 -1 5.18089128088497 4170 4409 3354 4569 2569 2731 4548 4131 2899 4059 4471 4501 M14109 GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. 78/183 Gene Ontology BP GO:0072331 8.78704938580202e-07 4.03144963421727e-06 4140 3626 4137 7.98822990495555e-08 897 1.80497249229063 -1.46059037255037 -1 11.534610768901 4137 4603 2740 4525 897 3443 4387 4293 2423 3896 4542 4502 M14979 GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS.html The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. 5/26 Gene Ontology BP GO:0006607 0.5857498601833 0.614190740928424 4600 3826.36363636364 4139 0.0843568170993044 2665 1.34824762394403 -1.71520458820943 -1 0.338111361808906 4597 3300 4328 2665 4363 4583 4516 2847 4139 3001 3751 4503 M12199 GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. 7/26 Gene Ontology BP GO:0002829 0.903850458811545 0.922122100694793 4345 4142 4140 0.208784618293744 3719 0.809494824895457 -0.809494824895457 -1 0.0337641580888301 4343 4109 3867 4395 4140 3978 3719 4325 4402 4320 3964 4504 M14416 GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. 11/18 Gene Ontology BP GO:2000001 0.859945765849168 0.880425179898057 3625 3910.54545454545 4140 0.163645173420165 2794 0.162127572409032 -0.241325370263973 -1 0.0106206378836238 3625 4566 3273 4419 4310 2794 4140 3603 4602 4478 3206 4505 M16816 GO_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_SPLICING.html Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 59/150 Gene Ontology BP GO:0043484 0.667434366415499 0.694664371949599 4235 4046.27272727273 4140 0.0952380952380952 3404 1.08556501644728 1.3193304994139 1 0.203472343142053 4235 4376 3404 4060 4418 3467 4292 3645 4140 4090 4382 4506 M13865 GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. 7/15 Gene Ontology BP GO:0051988 0.900476933159851 0.919084282405185 4380 3977.54545454545 4148 0.206051422284404 2722 0.260099274745531 -0.230584770495523 -1 0.011289202370637 4379 4044 4148 4242 4222 3373 2722 3918 4590 4445 3670 4507 M12682 GO_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 51/115 Gene Ontology BP GO:0051983 0.667434366415499 0.694664371949599 4295 4150.27272727273 4151 0.0952380952380952 3264 1.08589174970021 -1.10790040817893 -1 0.203533584734244 4295 4549 3264 4139 4285 4371 4442 4125 4151 4013 4019 4508 M12849 GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. 2/14 Gene Ontology BP GO:0072283 0.905024693811922 0.923117234922837 4490 3996 4152.5 0.23015873015873 3026 0.440045895925587 -0.423658084229909 -1 0.0181094316517637 4489 3026 3968 NA 4356 3873 3365 3640 4337 4362 4544 4509 M10893 GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. 4/48 Gene Ontology BP GO:0042738 0.785941684398692 0.810737000813847 4580 3897 4153 0.142857142857143 2772 1.08861813587471 -1.08861813587471 -1 0.117506310651903 4576 2827 3653 3632 4153 4338 4246 4141 4243 2772 4286 4510 M13619 GO_OXYGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORT.html The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/19 Gene Ontology BP GO:0015671 0.996895532355506 0.99996766030127 3775 4126.90909090909 4162 0.438695254693886 3454 0.602807199894982 0.610006192986531 1 8.3478708046465e-06 3775 3588 4106 3869 4561 4162 3454 4605 4520 4429 4327 4511 M15996 GO_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_DUPLICATION.html The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 17/48 Gene Ontology BP GO:0051298 0.834367499525838 0.855526410033851 4005 4001.81818181818 4163 0.150793650793651 2814 0.843424586917042 0.888300514994343 1 0.0677063084621417 4005 4163 2814 4173 4565 4305 4093 3716 4264 3469 4453 4512 M13414 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS.html Splicing of RNA via a series of two transesterification reactions. 157/364 Gene Ontology BP GO:0000375 0.796944161638877 0.820628020068597 4445 4021.09090909091 4172 0.134920634920635 3363 0.990790380718845 -0.695595769904693 -1 0.10076540168259 3402 4595 3511 4441 4552 3363 3743 4442 4237 4172 3774 4513 M15460 GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 5/21 Gene Ontology BP GO:0035413 0.879136193892288 0.898993446150604 4420 4100.09090909091 4173 0.19047619047619 2888 0.283070687537565 -0.198072893247221 -1 0.0155051636748868 4416 3848 4411 2888 4161 4050 3827 4173 4302 4553 4472 4514 M16240 GO_PEPTIDYL_LYSINE_DIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_DIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. 7/15 Gene Ontology BP GO:0018027 0.744146400540234 0.771049260814173 4600 3973.72727272727 4173 0.127432258751245 3054 0.227673946692291 -0.190450656750792 -1 0.030453004796387 3669 4173 4532 4402 4598 3266 3173 3683 4565 4596 3054 4515 M15572 GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION.html Any process that modulates the frequency, rate or extent of cytoplasmic translation. 8/17 Gene Ontology BP GO:2000765 0.0982941848282471 0.110798713318172 4430 4042.27272727273 4174 0.0102933530121276 3256 0.276870448165281 -0.345856510820644 -1 0.313377120886662 4075 4205 4426 4454 3637 3568 3256 4174 4428 4565 3677 4516 M16605 GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY.html Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex. 6/15 Gene Ontology BP GO:0051488 0.253058350757625 0.274842087150328 2915 3603.27272727273 4174 0.0287552872143503 1489 0.306663775775875 -0.479359311246609 -1 0.203767733266377 2911 4174 4590 4549 4636 2371 1489 2855 4580 4621 2860 4517 M14552 GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER.html The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. 50/91 Gene Ontology BP GO:0006890 0.984511587464037 0.994467127727277 3560 4055.81818181818 4177 0.315371185899756 3335 0.731054299217609 -0.759294152091818 -1 0.00208505143786034 3560 4377 3344 4536 4232 4048 3335 4177 4431 4110 4464 4518 M11926 GO_INTRA_S_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_S_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. 6/13 Gene Ontology BP GO:0031573 0.975827760595686 0.988298869996805 4165 4226 4180 0.310821550467974 3826 0.167634464463667 -0.265870307096291 -1 0.00101341369560883 4163 4455 3826 4553 4227 3998 4161 4028 4597 4298 4180 4519 M14706 GO_RRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an rRNA molecule. 7/14 Gene Ontology BP GO:0031125 0.598881260040338 0.626685979348048 4625 4220 4182 0.0873015873015873 3752 0.707165889235958 0.707165889235958 1 0.170013814471916 4622 3752 4276 3937 4182 3931 4511 4147 4123 4495 4444 4520 M16264 GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that activates or increases the frequency, rate or extent of receptor recycling. 8/17 Gene Ontology BP GO:0001921 0.193456887517014 0.213252689634734 4225 4202.90909090909 4186 0.021270319598525 3741 0.433080015863132 -0.433080015863132 -1 0.344298326023805 4224 3750 4537 3830 3741 4157 4186 4618 4454 4599 4136 4521 M14303 GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-RNA complex into its constituent components. 10/17 Gene Ontology BP GO:0032988 0.232850105696956 0.253922063757934 4510 4004.36363636364 4190 0.0238095238095238 2744 0.593097012655392 -0.593097012655392 -1 0.41825164154752 4509 3915 3116 4281 3873 4579 4563 2744 3815 4463 4190 4522 M15090 GO_REGULATION_OF_CHOLESTEROL_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_STORAGE.html Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 9/23 Gene Ontology BP GO:0010885 0.965428386966392 0.979135867340533 4215 4141.90909090909 4190 0.285714285714286 3508 1.02563640966284 -1.02563640966284 -1 0.0111240005449035 4212 3920 4348 4087 4422 4278 4190 4025 4400 3508 4171 4523 M13263 GO_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 8/21 Gene Ontology BP GO:0090140 0.0765897756730953 0.0916038970762961 4195 3966.18181818182 4192 0.00793650793650794 2189 1.39432368163873 -0.936457813048449 -1 1.71464664577488 4192 3949 4039 3734 4614 4316 4487 4331 2189 3388 4389 4524 M11092 GO_WHITE_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_WHITE_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. 12/20 Gene Ontology BP GO:0050872 0.878859116702268 0.898993446150604 4405 4016.72727272727 4195 0.174603174603175 2578 1.47591627039601 -1.47591627039601 -1 0.0808502271690562 4404 4166 2578 3717 4195 4473 4600 4247 4291 3693 3820 4525 M15166 GO_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. 160/378 Gene Ontology BP GO:0033044 0.0839184282471183 0.0949861682962873 3775 4061.36363636364 4195 0.00793650793650794 3143 1.34853492470444 -1.27686368182247 -1 1.63318374782679 3774 4525 3143 4195 4569 4271 4056 4461 3429 4042 4210 4526 M11691 GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. 12/19 Gene Ontology BP GO:2000104 0.726270090971166 0.753030824559875 4200 4050.90909090909 4197 0.111111111111111 3095 0.807878215707367 -0.517174830436356 -1 0.117891786880507 4365 4199 3095 4490 4164 4641 4336 3364 4197 3694 4015 4527 M10884 GO_SNORNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. 5/12 Gene Ontology BP GO:0016074 0.986100259595109 0.995318153326107 4010 4128.63636363636 4198 0.347920317104319 3532 0.137704677363111 -0.17225908651788 -1 0.000330784030217151 4007 4398 3652 4492 4265 3916 3532 4198 4626 4227 4102 4528 M13222 GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. 6/14 Gene Ontology BP GO:0050812 0.652785949006218 0.680944767745645 4525 4208.54545454545 4200 0.100378700691676 3712 0.250134976706551 -0.192413936590474 -1 0.0494496428858611 4521 3725 4035 3712 4002 4518 4200 4446 4619 4391 4125 4529 M15234 GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. 6/23 Gene Ontology BP GO:0051883 0.386086746459241 0.413613466499828 3945 4060.27272727273 4201 0.0476190476190476 2938 0.949770503685069 -0.949770503685069 -1 0.431373271698934 4476 2938 4374 3743 3943 4201 4534 3734 3941 4534 4245 4530 M13959 GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 10/23 Gene Ontology BP GO:1900103 0.360541939319577 0.38714066240999 4080 3930.54545454545 4203 0.0398334955386585 2798 0.884890154824906 -0.901398622933675 -1 0.432017440604325 4077 4203 2798 3094 3861 4572 4474 2859 4424 4448 4426 4531 M11254 GO_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 72/165 Gene Ontology BP GO:0051340 0.796944161638877 0.820628020068597 3745 4050.45454545455 4204 0.134920634920635 3454 0.872466720331951 -0.830108012894559 -1 0.0887314433515113 3744 4476 3454 4509 4204 3495 4428 4263 4241 4097 3644 4532 M14133 GO_TOXIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_TRANSPORT.html The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/59 Gene Ontology BP GO:1901998 0.067657573038986 0.0822771376689397 3915 3911.36363636364 4205 0.00634841050079259 1822 0.806965285901993 -0.561262134236352 -1 1.03693188291085 3914 4434 2996 4188 4462 4205 4277 1822 4334 3882 4511 4533 M16313 GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. 9/18 Gene Ontology BP GO:1903209 0.892829984701391 0.912081324305514 3725 4060.36363636364 4206 0.200152246660402 3073 0.521781820512482 -0.521781820512482 -1 0.024702045045369 3724 4206 4546 4410 4559 3073 3783 3857 4572 4604 3330 4534 M13792 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. 80/189 Gene Ontology BP GO:1903747 0.00524040284415399 0.00720924160160207 4495 3825.90909090909 4208 0.00047753884335977 2422 1.52775307180352 -0.863984620014441 -1 3.87679585654012 4491 4272 3127 4426 3211 2934 4208 4578 2422 4023 4393 4535 M14955 GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM.html A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). 10/21 Gene Ontology BP GO:0034975 0.994119870209534 0.99996766030127 3915 4052.45454545455 4208 0.37307297412221 3062 0.175818762243635 0.186811379592168 1 1.24356707826953e-06 3913 4208 3062 3506 4315 4643 3285 4071 4625 4508 4441 4536 M15817 GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. 14/49 Gene Ontology BP GO:1901186 0.751985672431077 0.778303494671754 4325 3926.45454545455 4208 0.119047619047619 2339 1.48593063944788 -2.21338196512368 -1 0.191604334138837 4324 4443 2339 4554 4426 4466 2911 4097 4208 3786 3637 4537 M10447 GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. 32/77 Gene Ontology BP GO:2000573 0.0839184282471183 0.0949861682962873 4430 3890.09090909091 4209 0.00793650793650794 2388 1.46129946899144 -1.26175142677012 -1 1.76975077870364 4209 4430 2388 4579 4434 3813 4248 3723 3448 3092 4427 4538 M10625 GO_POSITIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RNA_SPLICING.html Any process that activates or increases the frequency, rate or extent of RNA splicing. 14/44 Gene Ontology BP GO:0033120 0.775777090327069 0.800607475080814 3655 3793.09090909091 4209 0.127087107951501 2427 0.789619679568588 -0.789619679568588 -1 0.0903393158849653 3653 4348 3083 4374 4481 2601 2427 4614 4622 4209 3312 4539 M12696 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 6/15 Gene Ontology BP GO:0032968 0.00188379400909668 0.00271797873966311 4255 3901.81818181818 4209 0.000188539282286332 2825 0.852049796352599 0.852049796352599 1 2.58974976244157 4253 2825 3952 3517 3062 4499 4209 3516 4479 4353 4255 4540 M13065 GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT.html Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. 7/19 Gene Ontology BP GO:2000641 0.998444987429173 0.99996766030127 4005 4248.90909090909 4211 0.476190476190476 3966 0.754639173726346 0.754639173726346 1 1.0874076112234e-05 4513 4211 4005 3966 4494 4081 4003 4202 4539 4379 4345 4541 M10379 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 7/25 Gene Ontology BP GO:1900153 0.269609901713973 0.292135069698478 4610 4076.45454545455 4212 0.0309292444713042 2415 0.237339206957933 -0.149559764259458 -1 0.150252749233724 4607 3951 3576 4103 4212 4388 4638 2415 4436 4199 4316 4542 M15163 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION.html The process in which immune receptor genes are diversified through somatic mutation. 6/14 Gene Ontology BP GO:0002566 0.100394970549844 0.113139283558963 4205 4141.18181818182 4212 0.0105241760349317 3641 0.654162550255648 -0.654162550255648 -1 0.733383871734183 4204 4212 4364 4347 3641 4449 3878 3842 4260 4528 3828 4543 M14361 GO_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. 10/18 Gene Ontology BP GO:0030851 0.640683615099121 0.66907198041053 2870 3680.45454545455 4214 0.0888522225461806 2525 0.845190723269774 0.845190723269774 1 0.174739729223163 2866 4254 2525 4358 4428 3244 2744 4508 4214 4466 2878 4544 M13612 GO_MEIOTIC_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEPARATION.html The process in which chromosomes are physically detached from each other during meiosis. 8/12 Gene Ontology BP GO:0051307 0.479621489371513 0.508072684269207 3925 4257.90909090909 4215 0.0632322403689913 3879 0.422927907211478 0.345458145489809 1 0.147331748663734 4185 3921 4104 4355 3925 4607 3879 4215 4598 4427 4621 4545 M15903 GO_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 939/2159 Gene Ontology BP GO:0033554 6.09257962457763e-07 3.23212152206309e-06 4395 3700.18181818182 4217 6.09258129495695e-08 786 1.45981622943139 -1.2171954633004 -1 9.49487130513638 4393 4217 4477 4429 786 2604 4518 4566 2748 4024 3940 4546 M10731 GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA processing. 21/61 Gene Ontology BP GO:0050685 0.691241943157975 0.718476906667221 4590 4019.36363636364 4219 0.101327062623536 2946 0.203993890618577 -0.17063730429392 -1 0.0346968380368819 4587 4439 3300 4376 4307 3831 3466 2946 4618 4219 4124 4547 M10217 GO_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_RECOMBINATION.html Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. 32/91 Gene Ontology BP GO:0000018 0.996155202077478 0.99996766030127 4640 4157.27272727273 4220 0.396825396825397 3226 0.689365668158064 -0.809494824895457 -1 9.78804481032535e-06 4638 4488 3226 4267 4453 3954 4035 3768 4491 4190 4220 4548 M15953 GO_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXECUTION_PHASE_OF_APOPTOSIS.html A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. 32/76 Gene Ontology BP GO:0097194 0.526329415585462 0.555144815212017 4415 4147.45454545455 4223 0.0656752444137516 3118 0.800595896777175 -0.837554011484312 -1 0.242403347935055 4415 4487 3118 4566 3933 4072 4486 3879 4411 4032 4223 4549 M16727 GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. 9/19 Gene Ontology BP GO:0006515 0.872375660239041 0.892560641359601 4225 4090 4225 0.186058202662544 3022 0.244338922484948 0.219977693747177 1 0.0142861346502107 4225 4171 4612 4366 4282 3593 3022 4187 4624 4628 3280 4550 M14464 GO_DSRNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DSRNA_FRAGMENTATION.html Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. 12/29 Gene Ontology BP GO:0031050 0.796944161638877 0.820628020068597 4460 3934.72727272727 4228 0.134920634920635 2926 1.00829358059891 -0.728664828899404 -1 0.102545542504201 4456 3691 3110 2926 4392 4619 3202 4386 4228 3703 4569 4551 M16759 GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA.html The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. 12/29 Gene Ontology BP GO:0070918 0.796944161638877 0.820628020068597 4460 3935.81818181818 4229 0.134920634920635 2927 1.00829358059891 -0.728664828899404 -1 0.102545542504201 4457 3692 3111 2927 4393 4620 3203 4385 4229 3707 4570 4552 M11505 GO_HISTONE_H2A_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_UBIQUITINATION.html The modification of histone H2A by addition of one or more ubiquitin groups. 15/20 Gene Ontology BP GO:0033522 0.0892579401116945 0.100906894555295 4410 4058.81818181818 4231 0.00846357703806901 3237 0.641409638069669 -0.465409981814548 -1 0.756844173121194 4409 3836 3237 4231 3608 3565 4342 4627 4433 4273 4086 4553 M11992 GO_REGULATION_OF_CENTRIOLE_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTRIOLE_REPLICATION.html Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. 9/18 Gene Ontology BP GO:0046599 0.931034976730966 0.948397410478691 4605 4103.09090909091 4235 0.234645061762718 3398 0.576913426410245 -0.428272378040147 -1 0.0157236052973392 4602 3505 3840 3895 4572 3944 4235 3398 4560 4306 4277 4554 M14253 GO_REGULATION_OF_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ISOTYPE_SWITCHING.html Any process that modulates the frequency, rate or extent of isotype switching. 10/29 Gene Ontology BP GO:0045191 0.936989803160346 0.954044661419624 3820 4033.27272727273 4237 0.222222222222222 2960 0.809494824895457 -0.809494824895457 -1 0.0195907371885628 3818 4447 2960 4495 4237 4054 3006 4360 4332 4461 4196 4555 M11531 GO_BLASTOCYST_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_FORMATION.html The initial formation of a blastocyst from a solid ball of cells known as a morula. 13/34 Gene Ontology BP GO:0001825 0.00210600002689561 0.00302168050830542 4280 3937.81818181818 4239 0.00019163806811676 2769 0.736356508329747 0.689959258716076 1 2.19797933048965 4548 3378 2769 4354 3065 3867 4280 4180 4360 4276 4239 4556 M13529 GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN.html The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. 7/25 Gene Ontology BP GO:0032490 0.961389229168377 0.97546551377377 4245 4260.54545454545 4241 0.277777777777778 3992 0.9392360253186 0.9392360253186 1 0.012001517008921 4241 4213 4092 4098 4439 4062 4300 3992 4391 4419 4619 4557 M11747 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion. 8/14 Gene Ontology BP GO:2000484 0.0765897756730953 0.0916038970762961 4295 3770.72727272727 4242 0.00793650793650794 1733 1.5465248701425 1.55197843219228 1 1.90181374101219 4242 3022 3799 3039 4291 4294 4501 4635 3569 1733 4353 4558 M13663 GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. 61/139 Gene Ontology BP GO:0051351 0.949776431494504 0.964947914973519 4480 4167.18181818182 4243 0.238095238095238 3432 0.840643288059521 -0.738222010058104 -1 0.0154299924453185 4243 4478 3432 4380 4477 3825 4232 4285 4353 4101 4033 4559 M12000 GO_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule. 22/83 Gene Ontology BP GO:0070988 0.906512290741 0.92443148822984 4255 4082.36363636364 4254 0.193819611808743 3275 1.08861813587471 -1.08861813587471 -1 0.044006128743208 4254 4438 3306 4507 4512 3766 4459 3275 4584 3954 3851 4560 M14604 GO_FUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. 5/15 Gene Ontology BP GO:0006004 0.698333330399518 0.725036147818641 3690 3855.27272727273 4255 0.112940537740184 2959 0.171201906739471 -0.262483226816837 -1 0.02831860185542 3687 4399 4255 4401 4450 3052 2959 3136 4585 4488 2996 4561 M14619 GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. 17/32 Gene Ontology BP GO:0000289 0.901670213075579 0.920099955892288 3970 4010.81818181818 4255 0.190110221178102 2943 0.191434532450496 -0.180276673323982 -1 0.00819969447975208 3968 4628 3375 4255 4550 2943 3595 4538 4482 4489 3296 4562 M16654 GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 4/15 Gene Ontology BP GO:0060628 0.59508108721513 0.623693338135406 4545 3815.18181818182 4256 0.0864405671842087 2858 0.296825923965645 -0.333277480045181 -1 0.0720916340704499 4544 2941 4596 3042 4352 3368 2976 2858 4410 4624 4256 4563 M11331 GO_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEPARATION.html The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). 14/21 Gene Ontology BP GO:0051304 0.999590520100346 0.99996766030127 4415 4168 4262 0.507936507936508 2661 0.689550038146136 -0.689550038146136 -1 9.79111238845579e-06 4412 3976 2661 4403 4612 4185 4454 4075 4554 4262 4254 4564 M12433 GO_RNA_SURVEILLANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SURVEILLANCE.html The set of processes involved in identifying and degrading defective or aberrant RNAs. 9/14 Gene Ontology BP GO:0071025 0.76527490244494 0.791528485643096 4320 4201.63636363636 4262 0.134920634920635 3845 0.696617645837151 0.696617645837151 1 0.0837862983468021 4320 3845 3907 3899 4493 3928 4619 4366 4240 4339 4262 4565 M14218 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. 39/67 Gene Ontology BP GO:0000288 0.977387807402356 0.98932016345523 3800 4102.90909090909 4262 0.291410375802443 3277 0.64621637343787 -0.64621637343787 -1 0.00356804079359233 3799 4621 3446 4434 4475 3277 4072 4262 4605 4459 3682 4566 M14424 GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. 11/29 Gene Ontology BP GO:0031442 0.549216677247725 0.578890586256797 4505 4021.90909090909 4262 0.069872401258491 2739 0.256658963028863 -0.195668814887743 -1 0.0721791160181233 4501 3890 3247 4026 4092 4262 4375 2739 4355 4479 4275 4567 M11061 GO_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. 5/54 Gene Ontology BP GO:0042737 0.822436702569706 0.844630305249092 4605 4064 4266 0.158730158730159 2972 1.08861813587471 -1.08861813587471 -1 0.0945686981455676 4604 3389 3680 3999 4159 4498 4447 4375 4266 2972 4315 4568 M10298 GO_REGULATION_OF_RNA_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_STABILITY.html Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. 92/186 Gene Ontology BP GO:0043487 0.0839184282471183 0.0949861682962873 4520 4158.36363636364 4272 0.00793650793650794 3434 1.27484687388695 1.25295679686551 1 1.54394152745622 4519 4535 3434 4272 4364 4011 4547 4400 3611 4033 4016 4569 M11012 GO_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PHASE_TRANSITION.html The cell cycle process by which a cell commits to entering the next cell cycle phase. 152/387 Gene Ontology BP GO:0044770 0.0839184282471183 0.0949861682962873 4525 4114.54545454545 4273 0.00793650793650794 3360 1.2217171793537 1.42233653276473 1 1.47959714793801 4523 4410 3360 4273 4473 3722 4159 4324 3582 4132 4302 4570 M10686 GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE.html Any process in which a protein is transported to, or maintained at, the kinetochore. 7/13 Gene Ontology BP GO:0034501 0.997199246102742 0.99996766030127 4290 4173.90909090909 4279 0.444444444444444 3543 0.331192242851104 -0.38198248798515 -1 3.82869655702397e-06 4286 3703 3617 3543 4623 4279 4179 4612 4522 4214 4335 4571 M16035 GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION.html Any process that modulates the frequency, rate or extent of protein polyubiquitination. 8/20 Gene Ontology BP GO:1902914 0.792679592076097 0.817505852067818 4570 3792.63636363636 4281 0.145594165307711 2585 0.259438251932743 -0.304784235138469 -1 0.0268929422170228 3112 4570 4497 4413 4281 2771 2585 3208 4567 4587 3128 4572 M11670 GO_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_PRODUCTION.html The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 11/37 Gene Ontology BP GO:0032612 0.805029432055856 0.827851971879367 4435 4063.90909090909 4284 0.13811021720082 2783 0.26970291321584 -0.254261960660411 -1 0.0262120046245764 4435 4310 2783 4127 4382 4123 4451 3115 4611 4284 4082 4573 M12471 GO_LAGGING_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAGGING_STRAND_ELONGATION.html The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. 6/11 Gene Ontology BP GO:0006273 0.991981890398035 0.999353637832811 4265 4165.18181818182 4288 0.382826601390748 3356 0.253312406985169 0.199327852878139 1 8.25809318138452e-05 4264 3356 3914 3423 4288 4624 4083 4444 4492 4342 4587 4574 M13037 GO_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_CYCLE.html The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. 27/66 Gene Ontology BP GO:0007098 0.943712354754118 0.960257826676171 4630 4039 4288 0.23015873015873 3035 0.843424586917042 0.888300514994343 1 0.0175952356882405 4626 4288 3035 4417 4567 3640 3519 3737 4343 3863 4394 4575 M15037 GO_ORGANELLE_INHERITANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INHERITANCE.html The partitioning of organelles between daughter cells at cell division. 9/16 Gene Ontology BP GO:0048308 0.817407521875272 0.840022825158674 3825 4100.90909090909 4298 0.156377239455892 2505 0.145296990809526 0.182837955124801 1 0.013029437929565 3822 4637 4338 4315 4298 3906 2505 4089 4617 4517 4066 4576 M11518 GO_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_CHECKPOINT.html A cell cycle checkpoint that originates from the mitotic or meiotic spindle. 13/31 Gene Ontology BP GO:0031577 0.999795022692556 0.99996766030127 3645 4166.54545454545 4306 0.537937710365908 3199 0.463783137878565 -0.407978698483221 -1 6.03476563657221e-06 3644 4306 3199 3913 4412 4354 4505 4189 4575 4274 4461 4577 M13041 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. 12/21 Gene Ontology BP GO:1904357 0.99964250276833 0.99996766030127 3945 4146.27272727273 4309 0.513972152884191 2938 0.754639173726346 0.754639173726346 1 1.0874076112234e-05 3942 4309 2938 4183 4578 4387 3843 3959 4614 4374 4482 4578 M12109 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 7/21 Gene Ontology BP GO:0060213 0.198144485763033 0.218212724714839 4610 4099.36363636364 4310 0.0218406468272139 2273 0.237339206957933 -0.149559764259458 -1 0.185876252233066 4608 3952 3851 4104 4213 4389 4639 2273 4437 4310 4317 4579 M12154 GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. 10/32 Gene Ontology BP GO:0048026 0.992123047321904 0.999353637832811 4440 4086.63636363636 4314 0.356186854909122 3002 0.146062310967262 -0.141433875267794 -1 4.69049096850025e-05 4436 4571 3002 4326 4633 3750 3480 3679 4643 4314 4119 4580 M12169 GO_LATERAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. 4/14 Gene Ontology BP GO:0048368 0.83167954990331 0.852990534614771 4530 4071.90909090909 4317 0.163215381804769 2540 0.790776269138314 -0.790776269138314 -1 0.0646875234559675 4526 3704 3864 3815 4587 3925 2540 4608 4494 4317 4411 4581 M12888 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 7/21 Gene Ontology BP GO:0060211 0.227394175883359 0.248772657546286 4610 4122.09090909091 4318 0.0254686878471462 2337 0.237339206957933 -0.149559764259458 -1 0.169872120605317 4609 3953 3975 4105 4214 4390 4640 2337 4438 4364 4318 4582 M16540 GO_THYROID_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. 8/35 Gene Ontology BP GO:0030878 0.995175767192827 0.99996766030127 4580 4309.63636363636 4319 0.413398963837084 3504 0.704592815063925 -0.676971934891053 -1 1.00413965804586e-05 4383 4108 4576 3504 4319 4149 4574 4299 4579 4617 4298 4583 M12306 GO_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_ACTIVATION.html The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. 8/42 Gene Ontology BP GO:0045576 0.792896695857834 0.817548158753702 4625 4138.63636363636 4322 0.14568367999148 2451 0.636933935209298 -0.636933935209298 -1 0.0660090129053231 4625 4451 3888 4119 4231 4322 2451 4337 4589 4329 4183 4584 M15131 GO_HISTONE_H4_K16_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K16_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. 13/21 Gene Ontology BP GO:0043984 0.0839184282471183 0.0949861682962873 4370 4102.54545454545 4326 0.00793650793650794 3328 1.42371074176967 1.42371074176967 1 1.7242277740786 4370 4631 3328 4412 4201 3671 4492 4420 3521 3756 4326 4585 M12278 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C.html The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. 5/17 Gene Ontology BP GO:0006122 0.999920885634549 0.99996766030127 4535 4292.27272727273 4327 0.611111111111111 3880 0.152317940113351 -0.128332481256805 -1 8.52556541423506e-07 4406 4262 3880 4097 4472 4535 3935 4168 4601 4327 4532 4586 M14460 GO_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE.html The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. 744/1842 Gene Ontology BP GO:0007049 0.0765897756730953 0.0916038970762961 3455 4190.45454545455 4328 0.00793650793650794 3449 1.31255748177746 -1.09398640405769 -1 1.61409590588202 3454 4509 4238 4545 4362 4351 4059 4328 3449 4166 4634 4587 M16444 GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that activates or increases the frequency, rate or extent of gluconeogenesis. 4/18 Gene Ontology BP GO:0045722 0.797699419949844 0.821223593531513 4635 4321.90909090909 4330 0.147685822126978 3778 0.108628628086896 -0.137081994900961 -1 0.0110057105106005 4634 4143 4567 3778 4078 4430 4284 4065 4620 4612 4330 4588 M12541 GO_ARACHIDONIC_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_SECRETION.html The controlled release of arachidonic acid from a cell or a tissue. 2/14 Gene Ontology BP GO:0050482 0.822270829739638 0.844630305249092 4280 4155.4 4331.5 0.174646766553351 2589 0.0944397184557375 -0.0583970759285997 -1 0.00820248073161183 4277 4457 3927 NA 4538 4317 2589 3984 4639 4346 4480 4589 M12435 GO_MITOTIC_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis. 20/58 Gene Ontology BP GO:0090307 0.958179200180645 0.972633586890847 3680 4103.90909090909 4332 0.250671880433412 3113 0.327860093103976 0.371239282123794 1 0.0046786893291226 3677 4294 3113 4130 4389 4332 4525 3438 4458 4340 4447 4590 M10353 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. 9/23 Gene Ontology BP GO:0033962 0.979981486942864 0.991513193261215 4635 4219.45454545455 4333 0.323694091594978 3571 0.168455032745787 -0.197387795974197 -1 0.000736970732859011 4333 4450 3571 4047 4635 3668 4637 4575 4633 4196 3669 4591 M13120 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS.html Any microtubule cytoskeleton organization that is involved in mitosis. 20/58 Gene Ontology BP GO:1902850 0.959736075505711 0.974001005152571 3680 4109 4333 0.25325178839831 3114 0.327860093103976 0.371239282123794 1 0.00444171681459361 3678 4295 3114 4131 4390 4333 4526 3443 4459 4382 4448 4592 M13939 GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. 6/18 Gene Ontology BP GO:0032645 0.7320510523627 0.758685945562504 4400 4131.45454545455 4333 0.123392452488313 3047 1.5881758638962 -1.5881758638962 -1 0.225647287899859 4508 4396 4160 4399 4468 4261 4578 3047 4333 3142 4154 4593 M14364 GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 8/13 Gene Ontology BP GO:0009263 0.804956120936968 0.827851971879367 4485 4160.72727272727 4333 0.150793650793651 3161 0.625251470787461 -0.624831041899587 -1 0.0607694302838733 4482 3161 4230 3215 4150 4413 4333 4598 4257 4469 4460 4594 M13695 GO_HISTONE_H4_K8_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K8_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. 11/16 Gene Ontology BP GO:0043982 0.662271744420527 0.690529465381655 4635 3819.90909090909 4334 0.0939701823992644 2421 0.123764950883321 -0.148503625047251 -1 0.0235764750756279 2987 4633 3347 4560 4334 2421 3216 4390 4634 4433 3064 4595 M14977 GO_HISTONE_H4_K5_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K5_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. 11/16 Gene Ontology BP GO:0043981 0.662271744420527 0.690529465381655 4635 3828.09090909091 4335 0.0939701823992644 2422 0.123764950883321 -0.148503625047251 -1 0.0235764750756279 2988 4634 3348 4561 4335 2422 3217 4394 4635 4510 3065 4596 M12685 GO_PROTEIN_K11_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K11_LINKED_UBIQUITINATION.html A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. 17/35 Gene Ontology BP GO:0070979 0.985042929230615 0.994467127727277 4150 4183.36363636364 4342 0.317540381625495 3053 0.413456714029712 -0.413456714029712 -1 0.00117849577279455 4146 4342 3053 4501 4621 4113 4109 3602 4548 4352 4630 4597 M13478 GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY.html Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. 7/26 Gene Ontology BP GO:0001539 0.663427224845798 0.691423704816844 4465 4205.72727272727 4346 0.103174603174603 3563 0.651011572614421 -0.601300693377608 -1 0.123587481338335 4462 3751 4084 4346 4130 4553 4365 3563 4172 4414 4423 4598 M15308 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of magnesium ion across a membrane. 5/18 Gene Ontology BP GO:1903830 0.964864395312921 0.978777668218898 3030 4072 4348 0.284557486987777 3029 0.398730766684512 0.429373520667488 1 0.00439864482958282 3029 4176 4383 4348 4502 3740 3057 4580 4466 4542 3969 4599 M14734 GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 9/18 Gene Ontology BP GO:0009219 0.993896093908631 0.99996766030127 4500 4371.27272727273 4349 0.399433941082566 4021 0.431271265300111 -0.431271265300111 -1 5.4938277629823e-06 4528 4311 4284 4496 4302 4345 4349 4021 4599 4498 4351 4600 M11466 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING.html Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. 12/21 Gene Ontology BP GO:0000469 0.99065237270653 0.998821944483308 4490 4237.63636363636 4352 0.346089504507238 3181 0.707165889235958 0.707165889235958 1 0.00042716826269715 4486 4347 3181 4363 4263 3770 4540 4478 4564 4270 4352 4601 M15250 GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME.html The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. 8/23 Gene Ontology BP GO:0045292 0.991633685877468 0.999353637832811 4005 4208.63636363636 4353 0.380197367261556 3304 0.149367851068288 -0.212990228973877 -1 4.80044753373473e-05 4004 4353 4375 4464 4551 3882 3304 4140 4642 4537 4043 4602 M12787 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. 9/20 Gene Ontology BP GO:0000466 0.635450080213105 0.663905203066933 3970 4269 4358 0.095984866629776 3960 0.707165889235958 0.707165889235958 1 0.149023798382557 3970 4394 3960 4361 3996 4487 4044 4347 4576 4358 4466 4603 M14810 GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. 39/107 Gene Ontology BP GO:0048024 0.796944161638877 0.820628020068597 4485 4225.45454545455 4361 0.134920634920635 3331 1.36391800036828 1.78339826383907 1 0.138713874645257 3854 4485 3331 3989 4592 4521 4482 4361 4230 4070 4565 4604 M14652 GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. 5/12 Gene Ontology BP GO:0051292 0.646997034988942 0.675361338456307 4515 4293.18181818182 4370 0.0988899459393956 3817 0.723185891349516 -0.723185891349516 -1 0.146034417345164 4515 3899 4266 3817 3998 4486 4634 4464 4370 4493 4283 4605 M13274 GO_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. 8/19 Gene Ontology BP GO:0046931 0.946596086373448 0.962355749357951 3770 4272.54545454545 4371 0.253968253968254 3770 0.723185891349516 -0.723185891349516 -1 0.0142746473066909 3770 4257 4042 4024 4581 4176 4417 4586 4371 4398 4376 4606 M14987 GO_PRE_MIRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MIRNA_PROCESSING.html Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. 4/13 Gene Ontology BP GO:0031054 0.998759997745762 0.99996766030127 4465 4386.36363636364 4371 0.487914772658056 4230 0.101076917818615 -0.147776817246022 -1 0 4463 4400 4332 4230 4371 4347 4423 4253 4630 4512 4289 4607 M12565 GO_ORGANELLE_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FISSION.html The creation of two or more organelles by division of one organelle. 284/735 Gene Ontology BP GO:0048285 0.667434366415499 0.694664371949599 4590 4300 4379 0.0952380952380952 3473 1.0372412607545 -0.829462152733503 -1 0.194414728978938 4202 4586 3473 4589 4403 4231 4609 4501 4152 4175 4379 4608 M14998 GO_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 33/99 Gene Ontology BP GO:0051225 0.985023615986936 0.994467127727277 4425 4251.81818181818 4382 0.317460317460317 3189 0.933727654971515 -0.965919278855189 -1 0.00266356553049078 4635 4382 3189 4375 4545 4186 4422 3903 4422 4513 4198 4609 M13161 GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 9/21 Gene Ontology BP GO:0002183 0.663427224845798 0.691423704816844 4445 4280.36363636364 4384 0.103174603174603 3705 0.593097012655392 -0.593097012655392 -1 0.112592881094418 4443 4067 4026 4288 4574 4554 3705 4450 4165 4384 4428 4610 M13203 GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE.html Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 21/43 Gene Ontology BP GO:0072595 0.994883598314871 0.99996766030127 4620 4190.27272727273 4388 0.380952380952381 3268 0.730902555628495 0.740774367273599 1 1.04791423633678e-05 4619 4492 3268 4053 4525 3574 4108 4473 4480 4388 4113 4611 M11487 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. 59/102 Gene Ontology BP GO:0000070 0.99951171875 0.99996766030127 4550 4238.90909090909 4390 0.5 3220 0.795738720827094 -0.850968949537731 -1 1.15578971244055e-05 4100 4548 3220 4476 4579 4136 4390 4475 4546 4127 4031 4612 M16889 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 7/25 Gene Ontology BP GO:1900151 0.191851290886772 0.211533019137326 4610 4200.09090909091 4391 0.0210756568345854 2256 0.237339206957933 -0.149559764259458 -1 0.18967239563784 4610 3954 4632 4106 4215 4391 4641 2256 4439 4638 4319 4613 M16780 GO_MITOTIC_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CHROMOSOME_CONDENSATION.html The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. 10/15 Gene Ontology BP GO:0007076 0.99966755758001 0.99996766030127 4450 4226.45454545455 4398 0.517172049393376 2983 0.678103133435627 -0.678103133435627 -1 9.60065690858926e-06 4446 3868 2983 4093 4398 4268 4266 4525 4566 4632 4446 4614 M14122 GO_PROTEIN_K48_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. 13/28 Gene Ontology BP GO:0071108 0.710375904577757 0.736880099408965 4340 4051.45454545455 4404 0.106538422216083 2957 0.983865201326097 -0.983865201326097 -1 0.154547822091584 4337 4562 2957 4592 4404 3667 4545 2975 4476 4453 3598 4615 M12182 GO_BIOTIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOTIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. 6/13 Gene Ontology BP GO:0006768 0.668371636817244 0.695483977979037 4460 4318.27272727273 4406 0.104500873133421 3865 0.975979026679825 -0.975979026679825 -1 0.182339902166327 4460 4215 3865 4156 4008 4589 4460 4602 4421 4319 4406 4616 M13698 GO_AMINO_SUGAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 7/17 Gene Ontology BP GO:0046348 0.980479820544289 0.991801265095236 4435 4311 4407 0.325396825396825 3581 0.295690218029683 -0.300940163578354 -1 0.00125068827623151 4583 4138 4118 4521 4329 4407 3581 4553 4432 4434 4325 4617 M13243 GO_TOXIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. 3/16 Gene Ontology BP GO:0009404 0.999468458587661 0.99996766030127 4150 4357.81818181818 4409 0.529506410409614 4036 0.131272122071144 -0.129970932848006 -1 5.02392765644673e-07 4148 4355 4036 4457 4409 4432 4147 4453 4638 4394 4467 4618 M16660 GO_NUCLEAR_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 128/255 Gene Ontology BP GO:0098813 0.980714389232142 0.991822458986024 4150 4332.36363636364 4409 0.301587301587302 3339 0.873819089426603 -0.888016332096228 -1 0.00368969595308076 4147 4529 3339 4515 4626 4519 4398 4634 4409 4148 4392 4619 M15180 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 19/31 Gene Ontology BP GO:0032205 0.999940849178077 0.99996766030127 4410 4257.90909090909 4410 0.587301587301587 3166 0.628980361164498 0.608835280890207 1 8.78334415882176e-06 4410 4247 3166 4135 4485 4035 4568 4452 4591 4531 4217 4620 M15459 GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. 6/18 Gene Ontology BP GO:0014741 0.979771016449983 0.991513193261215 4105 4257 4410 0.32298637950657 3164 0.208642413033505 -0.115521469638561 -1 0.00091318694389442 4104 4573 4410 4044 4533 4053 3164 4288 4600 4552 4506 4621 M11360 GO_PROTEIN_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEALKYLATION.html The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 15/32 Gene Ontology BP GO:0008214 0.999943948877797 0.99996766030127 4565 4284.72727272727 4412 0.589316112152901 3311 0.202667589186242 -0.159937242684429 -1 1.69028226884096e-06 4562 4629 3311 4422 4553 3972 4412 4229 4612 4265 4165 4622 M16965 GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. 13/42 Gene Ontology BP GO:0048025 0.999419364322855 0.99996766030127 4550 4262.09090909091 4412 0.492063492063492 3183 0.21247557498263 -0.201392835158376 -1 1.8534691467452e-06 4550 4204 3183 3620 4624 4328 4507 4412 4544 4641 4270 4623 M15633 GO_FOREBRAIN_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. 2/14 Gene Ontology BP GO:0021877 0.946538932694676 0.962355749357951 4405 4281.8 4417.5 0.277777777777778 2880 0.708360501706818 -0.429241694115403 -1 0.0139819810043853 4401 2880 4434 NA 4503 4156 4559 4591 4397 4568 4329 4624 M11924 GO_NUCLEAR_PORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. 7/17 Gene Ontology BP GO:0006999 0.992735565696391 0.999408332941965 4190 4352.72727272727 4418 0.388888888888889 3824 0.723185891349516 -0.723185891349516 -1 0.00021851874413804 4189 4504 3824 4094 4564 4418 4382 4493 4487 4297 4628 4625 M13741 GO_PROTEIN_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMETHYLATION.html The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 15/32 Gene Ontology BP GO:0006482 0.999943948877797 0.99996766030127 4565 4300.90909090909 4423 0.589316112152901 3312 0.202667589186242 -0.159937242684429 -1 1.69028226884096e-06 4563 4630 3312 4423 4554 3973 4413 4226 4613 4437 4166 4626 M10176 GO_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 159/308 Gene Ontology BP GO:0007059 0.982992683943975 0.993693671141275 4300 4358.36363636364 4424 0.30952380952381 3411 0.85519364171527 -0.869726269657377 -1 0.00278172391551483 4296 4528 3411 4603 4631 4424 4543 4594 4416 4159 4337 4627 M13328 GO_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_NUCLEAR_DIVISION.html A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. 222/475 Gene Ontology BP GO:0007067 0.726270090971166 0.753030824559875 4585 4309.63636363636 4425 0.111111111111111 3467 1.00759572762555 -0.803584126455853 -1 0.147036514099756 4582 4590 3467 4516 4607 4074 4425 4531 4193 4169 4252 4628 M11284 GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. 5/16 Gene Ontology BP GO:0043922 0.995536900026699 0.99996766030127 4645 4381.81818181818 4440 0.417945486198503 3724 0.130150479167234 -0.106389390809122 -1 4.83730686863943e-07 4440 4643 3724 4114 4323 4616 4379 4512 4641 4258 4550 4629 M16550 GO_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PROCESS.html The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. 626/1538 Gene Ontology BP GO:0022402 0.0765897756730953 0.0916038970762961 3955 4270 4442 0.00793650793650794 3487 1.32309447237544 -1.08756178282129 -1 1.62705360970913 3951 4510 4578 4442 4224 4079 4449 4628 3487 4167 4455 4630 M13145 GO_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other. 68/132 Gene Ontology BP GO:0007062 0.936989803160346 0.954044661419624 4145 4306.36363636364 4443 0.222222222222222 3126 1.08510882708785 -1.27159171786864 -1 0.026261496316235 4141 4609 3126 4571 4611 4597 4309 4581 4335 4047 4443 4631 M12786 GO_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FISSION.html The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 7/15 Gene Ontology BP GO:0000266 0.999859013918043 0.99996766030127 4625 4415.63636363636 4444 0.587980639074164 3959 0.177653259934225 -0.174929735880897 -1 1.27408975202383e-06 4180 4395 3959 4364 4444 4506 4517 4625 4623 4357 4602 4632 M10699 GO_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CONDENSATION.html The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. 16/40 Gene Ontology BP GO:0030261 0.99996766030127 0.99996766030127 4630 4228.63636363636 4448 0.609344287718979 2868 0.678103133435627 -0.678103133435627 -1 9.60065690858926e-06 4002 4197 2868 3845 4454 4630 4607 4448 4621 4217 4626 4633 M15723 GO_ARACHIDONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONATE_TRANSPORT.html The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 2/14 Gene Ontology BP GO:1903963 0.822270829739638 0.844630305249092 4280 4231.3 4453 0.174646766553351 2590 0.0944397184557375 -0.0583970759285997 -1 0.00820248073161183 4278 4458 4448 NA 4539 4318 2590 3987 4640 4574 4481 4634 M15463 GO_RECIPROCAL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_DNA_RECOMBINATION.html A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules. 23/42 Gene Ontology BP GO:0035825 0.570689457724698 0.598940133864325 3950 4195.63636363636 4454 0.0739901725171035 3006 0.946874415814942 0.946874415814942 1 0.249703755786096 3949 4241 3006 4557 3959 4454 4592 3681 4523 4555 4635 4635 M16397 GO_RECIPROCAL_MEIOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_MEIOTIC_RECOMBINATION.html The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. 23/42 Gene Ontology BP GO:0007131 0.570689457724698 0.598940133864325 3950 4201.72727272727 4455 0.0739901725171035 3007 0.946874415814942 0.946874415814942 1 0.249703755786096 3950 4242 3007 4558 3960 4455 4593 3686 4524 4608 4636 4636 M10195 GO_NUCLEOSOME_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_DISASSEMBLY.html The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. 17/41 Gene Ontology BP GO:0006337 0.997132701412606 0.99996766030127 4540 4155.63636363636 4461 0.412698412698413 2884 0.677485948540775 -0.692661823509764 -1 9.59038808498251e-06 4537 3552 2884 3607 4435 4461 4587 4468 4503 4189 4489 4637 M10543 GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-DNA complex into its constituent components. 17/41 Gene Ontology BP GO:0032986 0.997132701412606 0.99996766030127 4465 4157.45454545455 4462 0.412698412698413 2885 0.677485948540775 -0.692661823509764 -1 9.59038808498251e-06 4538 3553 2885 3608 4436 4462 4588 4462 4504 4206 4490 4638 M15791 GO_RRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. 13/28 Gene Ontology BP GO:0000154 0.992250758218665 0.999353637832811 4465 4289.54545454545 4462 0.357142857142857 3219 0.254792072603525 -0.219446264252729 -1 8.30731326164902e-05 4574 4305 3219 4463 4476 4584 3876 4276 4462 4577 4373 4639 M12941 GO_CHROMATIN_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DISASSEMBLY.html The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. 17/41 Gene Ontology BP GO:0031498 0.997132701412606 0.99996766030127 4540 4173.45454545455 4463 0.412698412698413 2886 0.677485948540775 -0.692661823509764 -1 9.59038808498251e-06 4539 3554 2886 3609 4437 4463 4589 4466 4505 4369 4491 4640 M16685 GO_GLYCOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. 9/26 Gene Ontology BP GO:0016137 0.630279547342001 0.659096382502007 4605 4139.90909090909 4468 0.0947107827153422 2909 0.660197797417513 -0.660197797417513 -1 0.141595064372049 3741 4502 4605 4524 4341 3515 4468 2909 4604 4627 3703 4641 M12981 GO_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. 108/204 Gene Ontology BP GO:0000819 0.996155202077478 0.99996766030127 4405 4319.27272727273 4479 0.396825396825397 3283 0.874024607526752 -0.93241409936334 -1 1.28604305598828e-05 4405 4532 3283 4479 4639 4221 4595 4513 4489 4142 4214 4642 M12352 GO_CENTRIOLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE_ASSEMBLY.html A cellular process that results in the assembly of one or more centrioles. 9/27 Gene Ontology BP GO:0098534 0.999935626529626 0.99996766030127 4595 4375.27272727273 4494 0.619047619047619 3894 0.725554474780344 0.725554474780344 1 1.03901601161963e-05 4595 4565 3894 4494 4500 4030 4250 4521 4603 4332 4344 4643 M16317 GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS.html The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. 7/16 Gene Ontology BP GO:0071428 0.944535148379988 0.960884464050895 3880 4338.90909090909 4547 0.251138013628113 3439 0.101612721284382 -0.0508671159027129 -1 0.00208422739607777 3876 4572 4547 4048 4511 4566 4614 3439 4636 4605 4314